@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : VIPR2_HUMAN: (2016-01-15 )
MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI
Atome Classification :
(20 SA)
-----------------------------------.........10.....--...20.---.......30........40...------...------..50------.......-.60.--.......70....-....80----------------...--.--.--....90........--------------------100---...--....110-----.........120........130.......140.......150......-.160.......170...--.....-180......-----.190..-.....200----.....------....210---..---......220.......230.....-----.----..240.--......250.......260-..-..---...270-.-----------------.--....---.--------.------.-280---.----.......290----......-..300.......310---...------------.....320..-.....330---..----.....340......--.350---.---.------------.----..--...----.360...---....370......--------.380.......390.......400.......410.....--..420.......430......------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------MRTLL
P
P
A
L
L
T
C
W
L
LA--
P
V
NSIH---PE
C
R
F
H
L
E
IQ
E
E
E
T
K
C
A
E
L
L
R
S
------
Q
T
E
------
K
H
K
A
------CSGVWDN-ITCW--RPANVG
E
T
V
T
VP
C
-
P
K
V
F
S
-----------------
N
F
Y
--
S
--K--AGNISKNCTSDGWS--------------------
E
T
F
---
P
D
F
--
V
D
ACG-------YSDPEDES
K
I
T
-
F
Y
I
L
V
K
A
I
Y
TLGY
S
V
S
L
M
S
LA
T
G
S
I
I
L
C
L
F
R
K
L
H
CTR-
N
Y
I
H
L
N
L
F
L
S
F
I
-
L
R
A
I
--
S
V
L
VK-D
D
V
L
YSSSG-----
T
L
HCPD-QPSSWV------
G
C
K
L
S
------
L
V
F
L
Q
Y
----
C
I
---
M
A
N
F
F
W
L
L
V
E
G
L
Y
L
H
T
L
L
-
V
A
ML
P
-----
P
----
R
R
C
F
L
A
--
Y
L
L
I
GWGL
P
T
V
C
I
G
A
W
T
A
A
-
R
L
-
Y
L
---EDTG---C-----------------W--DTND---H--------S------V-
P
W
----
W
----
V
I
R
I
P
I
L
I
S
-----
I
I
V
N
F
V
-
L
F
I
S
I
I
R
I
L
L
Q
K
LT----SPD------------VGGN
D
Q
S
Q
Y
K
-
R
L
A
K
S
T
L
L
---
L
I
----
P
L
F
G
V
H
Y
M
V
F
A
V
F
P
--IS-----I---S------------
S
----
K
Y
--
Q
I
L
----
F
E
L
C
L
G
S
---
F
Q
G
L
V
V
A
V
L
Y
C
F
L--------NSE
V
Q
C
E
L
K
R
K
W
R
SRCPTPSASRD
Y
R
VCGSSFSRNGSEG--
A
L
Q
FHRG
S
R
A
Q
S
F
L
Q
T
ETSVI------------------------------------------
1
PsiBlast_PDB
85.46
46%
-164
- C4 -
4L6R
1
C562_ECOLX (first)
A:
[122-394]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
S
F
Q
V
M
Y
T
V
G
Y
S
L
S
L
G
A
L
L
L
A
L
A
I
L
G
G
L
S
K
L
H
C
T
R
-
N
A
I
H
A
N
L
F
A
S
F
V
-
L
K
A
S
--
S
V
L
V
I
-
D
G
L
L
R
T
--------------------
L
SDGAVA
G
C
R
V
A
------
A
V
F
M
Q
Y
----
G
I
---
V
A
N
Y
C
W
L
L
V
E
G
L
Y
L
H
N
L
L
G
L
A
T
L
P
-----
E
----
R
S
F
F
S
L
--
Y
L
G
I
G
W
G
A
P
M
L
F
V
V
P
W
A
V
V
-
K
C
-
L
F
---
E
N
V
Q
---
C
-----------------
W
--
T
S
N
D
---
N
--------
M
------
G
-
F
W
----
W
----
I
L
R
F
P
V
F
L
A
-----
I
L
I
N
F
F
-
I
F
V
R
I
V
Q
L
L
V
A
K
L
R
----
A
R
Q
------------
M
H
H
T
D
---
Y
K
F
R
L
A
K
S
T
L
T
---
L
I
----
P
L
L
G
V
H
E
V
V
F
A
F
V
T
--
D
E
-----
H
---
A
------------
Q
G
T
L
R
S
A
--
K
L
F
----
F
D
L
F
L
S
S
---
F
Q
G
L
L
V
A
V
L
Y
C
F
L
--------
N
K
E
V
Q
S
E
L
R
R
R
W
H
R
W
R
L
G
K
V
L
W
E
E
R
N
------------------------------------------------------------------------------
2
PsiBlast_PDB
71.36
100%
-72
- C5 -
2X57
-
VIPR2_HUMAN
A:
[26-114]
-----------------------------------------------------------------
R
F
H
L
E
I
Q
E
E
E
T
K
C
A
E
L
L
R
S
------
Q
T
E
------
K
H
K
A
------
C
S
G
V
W
D
N
-
I
T
C
W
--
R
P
A
N
V
G
E
T
V
T
V
P
C
-
P
K
V
F
S
-----------------
N
F
Y
--
S
--
K
--
A
G
N
I
S
K
N
C
T
S
D
G
W
S
--------------------
E
T
F
---
P
D
F
--
V
D
A
C
G
-------
Y
S
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
68.95
35%
-125
- C4 -
4K5Y
2
CRFR1_HUMAN
C:
[286-422]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
C
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
-
K
L
-
Y
Y
---
D
N
E
K
---
C
-----------------
W
--
A
G
K
R
---
P
--------
G
------
V
Y
T
D
----
Y
----
I
Y
Q
G
P
M
A
L
V
-----
L
L
I
N
F
I
-
F
L
F
N
I
V
R
I
L
M
T
K
L
R
----
A
S
T
------------
T
--
S
E
T
I
Q
A
R
-
K
A
V
K
A
T
L
V
---
L
L
----
P
L
L
G
I
T
Y
M
L
A
F
V
N
P
GE
D
E
-----
V
---
S
------------
R
----
V
V
--
F
I
Y
----
F
N
A
F
L
E
S
---
F
Q
G
F
F
V
S
V
F
A
C
F
L
--------
N
-------------------------------------------------------------------------------------------------------
55
Fugue
66.13
18%
-102
- C2 -
4Q86
4
YCAO_ECOLI
A:
[2-583]
-------------T
Q
T
F
I
P
GKDAA
L
E
D
S
I
A
R
F
Q
Q
K
L
S
D
L
G
F
Q
I
E
E
A
S
W
L
N
P
VP
N
V
W
S
V
H
I
R
D
K
E
C
A
L
C
F
T
N
G
K
G
A
T
K
K
A
A
L
A
S
A
------
L
G
E
------
Y
F
E
R
------
L
S
T
N
Y
F
F
-
A
D
F
W
LG
E
T
I
A
N
G
P
F
V
H
Y
P
N
-
E
K
W
F
P
L
TENDDVPEGLLD
D
R
L
R
A
F
Y
--
D
--
P
--
E
N
E
L
T
G
S
M
L
I
D
L
Q
S
--------------------
G
N
E
---
D
R
G
--
I
C
G
L
P
-------
F
T
R
Q
S
D
N
Q
--
T
-
V
Y
I
P
M
N
I
I
G
N
L
-
Y
V
S
N
G
M
S
A
G
N
T
R
N
E
A
R
V
Q
G
L
S
E
V
F
E
-
R
Y
V
K
N
R
I
I
A
E
S
I
S
L
P
E
I
P
A
D
V
L
A
R
-
Y
P
A
V
V
E
A
I
E
-----
T
L
E
A
E
G
-
F
P
I
F
A
Y
------
D
G
S
L
G
GQYP
V
I
C
V
V
L
F
N
PANG
T
C
---
F
A
S
F
G
A
H
P
D
F
G
V
A
L
E
R
T
V
-
T
E
L
L
Q
-----
G
----
R
G
L
K
D
L
--
D
V
F
T
P
P
T
F
D
D
E
E
V
A
E
H
T
N
L
-
E
T
-
H
F
---
I
D
S
S
---
G
L
I
S
WDLFKQDADYPFVD
W
--
N
F
S
G
---
T
--------
T
------
E
-
E
E
----
F
----
A
T
L
M
A
I
F
N
K
E
D
K
E
V
Y
I
A
D
Y
E
H
L
G
V
Y
A
C
R
I
I
V
P
G
M
S
DIYP
A
E
D
------------
L
W
L
A
N
N
S
M
G
S
-
H
L
R
E
T
I
L
S
---
L
P
GSEW
E
K
E
D
Y
L
N
L
I
E
Q
L
D
E
--
E
G
-----
F
---
D
DF----------
T
----
R
V
--
R
E
L
----
L
G
L
A
T
G
S
DNG
W
Y
T
L
R
I
G
E
L
K
A
M
L
A
L
A
G
GD
L
E
Q
A
L
V
W
T
E
W
T
M
E
F
N
S
S
V
F
S
P
E
R
A
N
Y
Y
R
C
L
Q
T
L
L
L
L
A
Q
E
E
D
RQ
P
L
Q
Y
L
N
A
F
V
R
M
Y
G
A
D
A
V
E
A
A
S
A
A
M
S
GEAAFYGLQPVDSDLHAF
A
A
H
Q
S
L
L
K
A
Y
E
K
L
Q
R
A
K
A
A
F
49
Fugue
64.22
19%
-105
- C4 -
4K5Y
7
CRFR1_HUMAN (first)
A:
[13-423]
H
Y
H
V
A
A
I
I
N
Y
L
G
H
C
I
S
L
V
A
L
L
V
A
F
V
L
F
L
R
ARSIRC
L
R
N
I
I
H
A
N
L
I
A
A
F
I
L
R
--
N
A
T
W
F
V
---
V
Q
L
T
M
S
P
E
V
H
Q
S
N
V
G
W
C
R
L
V
T
A
------
A
Y
N
------
Y
F
H
V
------
T
-----
N
-
F
F
W
M
--
F
G
E
G
C
Y
L
H
T
A
I
V
L
-
T
N
I
F
E
-----------------
M
L
R
--
I
--
D
--
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
--------------------
Y
T
I
GIG
H
L
L
--
T
K
S
P
S
-------
L
S
V
A
K
S
E
L
D
K
A
-
I
G
R
N
S
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
-
V
Y
D
S
L
D
A
V
R
R
S
A
-
L
I
N
M
--
V
F
Q
M
G
-
E
T
G
V
A
G
F
T
N
-----
S
L
R
M
L
Q
-
Q
-
K
R
W
D
------
E
A
A
V
N
------
L
A
K
S
R
W
----
Y
N
---
Q
T
P
N
R
A
K
R
V
I
A
T
F
R
T
G
T
W
-
D
A
Y
D
R
-----
L
----
R
A
--
W
M
--
F
I
C
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
-
K
L
-
Y
Y
---
D
N
E
K
---
C
-----------------
W
--
A
G
K
R
---
P
--------
G
------
V
Y
T
D
----
Y
----
I
Y
Q
G
P
M
A
L
V
-----
L
L
I
N
F
I
-
F
L
F
N
I
V
R
I
L
M
T
K
L
R
----
A
S
--------------
T
T
S
E
T
I
Q
A
R
-
K
A
V
K
A
T
L
V
---
L
L
----
P
L
L
G
I
T
Y
M
L
A
F
V
N
----
E
-----
V
---
S
------------
R
----
V
V
--
F
I
Y
----
F
N
A
F
L
E
S
---
F
Q
G
F
F
V
S
V
F
A
C
F
L
--------
N
S
------------------------------------------------------------------------------------------------------
53
Fugue
59.83
20%
-107
- C3 -
4X90
12
PAG15_HUMAN
A:
[5-380]
---------------------------------------
H
P
P
V
V
L
V
------------
P
---
G
D
L
G
N
Q
L
E
A
K
L
D
K
P
---------------
T
V
------
V
H
Y
L
------
C
S
K
K
T
E
S
Y
F
T
I
W
--
L
N
L
E
L
L
L
P
V
I
I
D
C
W
I
D
N
I
R
-----------------
L
V
Y
--
N
--
K
--
T
S
R
A
T
Q
F
--
P
D
G
V
D
--------------------
V
R
V
---
P
G
F
GK
T
F
S
L
E
-------
F
L
D
P
S
K
S
S
V
G
S
Y
F
H
T
M
V
E
S
L
V
G
W
G
Y
T
R
G
------
E
D
V
R
G
A
P
Y
D
W
R
R
A
P
N
-
E
N
G
P
Y
F
L
A
L
R
E
M
-
I
E
E
M
--
Y
Q
L
Y
G
-
G
P
V
V
L
V
A
H
S
M
G
N
M
Y
T
L
Y
F
L
Q
R
Q
P
Q
A
W
K
------
D
K
Y
I
R
------
A
F
V
S
L
G
----
A
P
WGG
V
A
K
T
L
R
V
L
A
S
G
D
N
N
R
I
P
V
-
I
G
P
L
K
-----
I
----
R
E
Q
Q
R
S
--
A
V
S
T
S
W
L
L
P
Y
N
Y
T
--
W
S
P
E
-
K
V
-
F
V
---
Q
----------------------------
T
P
T
------------------------------------------------
I
N
Y
T
-
L
--
R
D
Y
R
K
F
F
Q
D
I
----------------------
G
F
E
D
G
W
L
M
-
R
Q
D
T
E
G
L
V
EAT
M
P
----
P
G
V
Q
L
H
C
L
Y
G
T
G
V
P
--
T
P
-----
D
---
S
------------
F
----
Y
Y
--
E
S
F
PD
R
D
P
K
I
C
F
G
D
---
G
D
G
T
V
------
N
L
--------
K
S
A
L
Q
C
Q
---
A
W
Q
S
R
-------
Q
E
H
Q
V
L
L
Q
E
L
P
--
G
S
E
H
---
I
E
M
L
A
N
A
T
T
L
A
Y
L
K
R
V
L
L
G
P
------------------------------------------
41
HHSearch
57.75
14%
-139
- C4 -
2KS9
1
NK1R_HUMAN
A:
[37-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
-
N
Y
F
L
V
N
L
A
F
A
E
A
-
S
M
A
A
--
F
N
T
V
V
-
N
F
T
Y
A
V
H
N
-----------
E
-
W
Y
Y
G
L
F
------
Y
C
K
F
H
------
N
F
F
P
I
A
----
A
V
---
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
-
I
H
P
L
Q
-----
P
RLS-
A
T
A
T
K
V
--
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
-
T
E
TMP
S
R
V
V
---
C
-----------------
M
--
I
E
W
P
EHP
N
--------
K
IY
E
K
V
-
Y
-
H
I
C
V
T
V
L
----
I
Y
F
L
P
L
L
V
I
-----
G
Y
A
-----
Y
T
V
V
G
I
T
L
W
A
S
E
I
----
P
G
D
SSD---------
R
Y
H
E
Q
V
S
A
K
R
-
K
V
V
K
M
M
I
V
---
V
V
----
C
T
F
A
I
C
W
L
P
F
H
I
F
F
--
L
L
P
Y
I
N-
P
---
D
LYLK--------
K
----
F
I
Q
Q
V
Y
L
----
A
I
M
W
L
A
M
---
S
S
T
M
Y
N
P
I
I
Y
C
C
L
--------
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
--
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
----------------------------------------------
54
Fugue
55.87
12%
-81
- C4 -
4JKV
10
C562_ECOLX (first)
A:
[2-470]
--------------------------------GTA
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
--
E
K
A
D
N
A
---
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
------
P
K
L
------
E
D
K
S
------
P
D
S
P
E
M
K
-
D
F
R
H
--
G
F
D
I
L
V
G
Q
I
D
D
A
L
-
K
L
A
N
E
-----------------
G
K
V
--
K
--
E
--
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
YIQKYLSGQCEVP
L
V
R
T
DNP
K
S
W
---
Y
E
D
--
V
E
G
C
G
I
Q
CQNPL
F
T
E
A
E
H
Q
D
M
H
S
-
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
-
A
Q
F
M
--
D
G
A
R
R
-
E
I
V
C
R
A
D
G
T
-----
M
R
L
G
E
P
-
T
S
N
E
T
L
------
S
C
V
I
I
------
F
V
I
V
Y
Y
----
A
L
---
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
-
K
A
L
G
T
-----
T
----
Y
Q
P
G
K
T
SY
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
-
A
Q
-
V
D
---
G
D
S
V
SG
I
C
-----------------
F
V
G
Y
K
N
Y
---
R
--------
Y
------
R
-
A
G
----
F
----
V
L
A
P
I
G
L
V
L
-----
I
V
G
G
Y
F
-
L
I
R
G
V
M
T
L
F
S
I
K
S
N
----
H
P
G
------------
L
L
S
E
K
A
A
----
S
K
I
N
E
T
M
L
---
R
L
----
G
I
F
G
F
L
A
F
G
F
V
L
I
T
--
F
S
-----
C
---
H
------------
F
----
Y
D
--
F
F
N
----
Q
A
----
E
---
W
E
R
S
F
R
D
Y
V
L
C
Q
A
--------
N
C
E
I
K
-----------
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
--
T
W
V
W
-
T
K
A
T
L
L
I
W
R
R
T
W
C
---------------------------------------------
29
HHSearch
55.50
9%
-141
- C4 -
2Z73
5
OPSD_TODPA
A:
[35-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
-
N
M
F
I
I
N
L
A
F
S
D
F
-
T
F
S
L
--
V
N
G
F
P
L
M
T
I
S
C
F
L
K
-----------
K
-
W
I
F
G
F
A
------
A
C
K
V
Y
------
G
F
I
G
G
I
----
F
G
---
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
-
G
R
P
M
A
A
S
K
K
M
S
----
H
R
R
A
F
I
--
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
-
Y
T
L
E
G
V
L
C
N
---
C
-----------------
S
--
F
D
Y
I
---
S
--------
R
D
S
T
T
R
S
N
-
I
L
----
C
----
M
F
I
L
G
F
F
G
P
-----
I
L
I
I
F
F
-
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
----
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
-
R
L
A
K
I
S
I
V
---
I
V
----
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
--
L
L
A
Q
FG-
P
LEW
V
------------
T
----
P
Y
--
A
A
Q
----
L
P
V
M
F
A
K
---
A
S
A
I
H
N
P
M
I
Y
S
V
S
--------
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
--
E
--------------------------------------------------------------
34
HHSearch
54.25
42%
-65
- C5 -
3N94
1
MALE_ECOLI
A:
[369-468]
--------------------------------------------------------------
N
A
A
A
E
F
A
I
F
K
K
E
Q
A
M
C
L
E
K
I
Q
R
A
N
E
L
M
G
F
N
D
------
S
S
P
G
------
C
P
G
M
W
D
N
-
I
T
C
W
--
K
P
A
H
V
G
E
M
V
L
V
S
C
-
P
E
L
F
R
-----------------
I
F
N
--
P
DQ
D
--
M
G
V
V
S
R
N
C
T
E
D
G
W
S
--------------------
E
P
F
---
P
H
Y
--
F
D
A
C
G
-------
F
D
E
Y
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
52.92
13%
-126
- C4 -
1U19
14
OPSD_BOVIN
A:
[44-326]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
-
N
Y
I
L
L
N
L
A
V
A
D
L
-
F
M
V
F
--
G
G
F
T
T
-
T
L
Y
T
S
L
H
G
-----------
Y
-
F
V
F
G
P
T
------
G
C
N
L
E
------
G
F
F
A
T
L
----
G
G
---
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
-
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
I
M
--
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
-
Y
I
P
E
G
M
Q
C
S
---
C
-----------------
G
--
I
D
Y
Y
---
T
PHEETN
N
E
S
------
F
-
V
I
----
Y
----
M
F
V
V
H
F
I
I
P
-----
L
I
V
I
F
F
-
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
----
Q
Q
Q
------------
E
S
A
T
T
Q
K
A
E
K
-
E
V
T
R
M
V
I
I
---
M
V
----
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
--
F
Y
I
F
T
H
Q
G
---
S
DF----------
G
----
P
I
--
F
M
T
----
I
P
A
F
F
A
K
---
T
S
A
V
Y
N
P
V
I
Y
I
M
M
--------
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------------------------------------------------------
43
HHSearch
51.72
13%
-141
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[43-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
-
D
V
Y
L
L
N
L
A
L
A
D
L
-
L
F
A
L
--
T
L
P
I
W
-
A
A
S
--
K
V
N
-----------
G
-
W
I
F
G
T
F
------
L
C
K
V
V
------
S
L
L
K
E
V
----
N
F
---
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
-
V
H
A
T
R
-----
T
LTQ
K
R
H
L
V
K
F
--
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
-
R
Q
A
Y
H
PNN
S
S
P
V
---
C
-----------------
Y
--
E
V
L
G
ND-
T
--------
A
KWRMV-
L
-
R
I
----
L
PHTF
G
F
I
V
P
L
F
V
M
---------
L
F
-
C
Y
G
F
T
L
R
T
L
F
K
A
H
-------------------------
M
G
Q
K
H
-
R
A
M
R
V
I
F
A
---
V
V
----
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
--
L
A
D
T
L
M
-
R
---
T
QVIQE
S
C
E
R
R
N
N
I
----
G
R
--
A
L
D
----
A
T
E
I
L
G
F
---
L
H
S
C
L
N
P
I
I
Y
A
F
I
--------
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
----------------------------------------------------------------------------------------
5
PsiBlast_PDB
51.32
44%
-47
- C5 -
3N94
1
MALE_ECOLI
A:
[378-469]
-----------------------------------------------------------------------
K
K
E
Q
A
M
C
L
E
K
I
Q
R
------
A
N
E
L
M
G
F
N
D
S
S
P
G
------
C
P
G
M
W
D
N
-
I
T
C
W
--
K
P
A
H
V
G
E
M
V
L
V
S
C
-
P
E
L
F
R
IF---------------
N
P
D
--
Q
--
D
--
M
G
V
V
S
R
N
C
T
E
D
G
W
S
--------------------
E
P
F
---
P
H
Y
--
F
D
A
C
G
-------
F
D
E
Y
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
48.71
35%
-137
- C4 -
4K5Y
7
CRFR1_HUMAN (first)
B:
[286-423]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
C
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
-
K
L
-
Y
Y
---
D
N
E
K
---
C
-----------------
W
--
A
G
K
R
--------------------Y
T
D
----
Y
----
I
Y
Q
G
P
M
A
L
V
-----
L
L
I
N
F
I
-
F
L
F
N
I
V
R
I
L
M
T
K
L
R
----
A
S
T
------------
T
--
S
E
T
I
Q
A
R
-
K
A
V
K
A
T
L
V
---
L
L
----
P
L
L
G
I
T
Y
M
L
A
------------------------------------
V
--
F
I
Y
----
F
N
A
F
L
E
S
---
F
Q
G
F
F
V
S
V
F
A
C
F
L
--------
N
S
------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
48.71
44%
-24
- C5 -
2JOD
-
PACR_HUMAN
A:
[28-122]
-----------------------------------------------------------------------
K
K
E
Q
A
M
C
L
E
K
I
Q
R
------
A
N
E
L
MGFND
S
S
P
G
------
C
P
G
M
W
D
N
-
I
T
C
W
--
K
P
A
H
V
G
E
M
V
L
V
S
C
-
P
E
L
F
R
-----------------
I
F
N
PD
Q
--
D
--
M
G
V
V
S
R
N
C
T
E
D
G
W
S
--------------------
E
P
F
---
P
H
Y
--
F
D
A
C
G
-------
F
D
E
Y
E
S
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
48.44
42%
-29
- C5 -
2JOD
-
PACR_HUMAN
A:
[17-122]
---------------------------------------------------------
M
G
---
S
M
A
H
S
D
G
I
F
K
K
E
Q
A
M
C
L
E
K
I
Q
R
------
A
N
E
------
L
M
G
F
NDSSPG
C
P
G
M
W
D
N
-
I
T
C
W
--
K
P
A
H
V
G
E
M
V
L
V
S
C
-
P
E
L
F
R
-----------------
I
F
N
--
P
--
D
QD
M
G
V
V
S
R
N
C
T
E
D
G
W
S
--------------------
E
P
F
---
P
H
Y
--
F
D
A
C
G
-------
F
D
E
Y
E
S
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
48.38
35%
-116
- C4 -
4K5Y
4
CRFR1_HUMAN (first)
A:
[286-423]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
C
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
-
K
L
-
Y
Y
---
D
N
E
K
---
C
-----------------
W
--
A
G
K
R
---
P
--------
G
------
V
Y
T
D
----
Y
----
I
Y
Q
G
P
M
A
L
V
-----
L
L
I
N
F
I
-
F
L
F
N
I
V
R
I
L
M
T
K
L
R
----
A
S
T
------------
T
--
S
E
T
I
Q
A
R
-
K
A
V
K
A
T
L
V
---
L
L
----
P
L
L
G
I
T
Y
M
L
A
F
V
N
----
E
-----
V
---
S
------------
R
----
V
V
--
F
I
Y
----
F
N
A
F
L
E
S
---
F
Q
G
F
F
V
S
V
F
A
C
F
L
--------
N
S
------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
48.17
39%
-51
- C5 -
2XDG
4
GHRHR_HUMAN
B:
[3-81]
----------------------------------------------------------------------
L
R
E
D
E
S
A
C
L
Q
A
A
E
E
------
M
P
Q
------
T
T
L
G
------
C
P
A
T
W
D
G
-
L
L
C
W
--
P
T
A
G
S
G
E
W
V
T
L
P
C
-
P
D
F
F
S
-----------------
H
F
S
--
S
--
E
--
S
G
A
V
K
R
D
C
T
I
T
G
W
S
--------------------
E
P
F
---
P
P
Y
--
P
V
A
C
P
-------
V
P
L
E
L
L
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
48.07
94%
71
- C5 -
2X57
-
VIPR2_HUMAN
A:
[-13-114]
----------------------------------------------------------------
M
R
F
H
L
E
I
Q
E
E
E
T
K
C
A
E
L
L
R
S
------
Q
T
E
------
K
H
K
A
------
C
S
G
V
W
D
N
-
I
T
C
W
--
R
P
A
N
V
G
E
T
V
T
V
P
C
-
P
K
V
F
S
-----------------
N
F
Y
--
S
--
K
--
A
G
N
I
S
K
N
C
T
S
D
G
W
S
--------------------
E
T
F
---
P
D
F
--
V
D
A
C
G
-------
Y
S
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
46.43
44%
-25
- C5 -
2JOD
-
PACR_HUMAN
A:
[23-118]
------------------------------------------------------------------
S
D
G
I
F
K
K
E
Q
A
M
C
L
E
K
I
Q
R
A
N
E
L
MG
F
N
D
------
S
S
P
G
------
C
P
G
M
W
D
N
-
I
T
C
W
--
K
P
A
H
V
G
E
M
V
L
V
S
C
-
P
E
L
F
R
-----------------
I
F
N
--
P
DQ
D
--
M
G
V
V
S
R
N
C
T
E
D
G
W
S
--------------------
E
P
F
---
P
H
Y
--
F
D
A
C
G
-------
F
D
E
Y
E
S
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------