@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MAPK2_HUMAN: (2015-10-13 )
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
Atome Classification :
(38 SA)
.........10........20........30........40........50...--.....60......-..70........80........90....-------.--------..-----.100-.......-----.110-----.......120.......130.......140.......150....--...160.......170.......180.......190.......200.......210.......-220.......230.......240.......250.......260...-....270.....--..280.......290.......300.......310.......320.....-..330----.--------.......340.......350.......360.......370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPP
P
Q
Q
F
P
Q
F
H
V
KSG
L
Q
I
--KKNAIID
D
Y
K
V
T
S
-
Q
V
LGLGIN
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
-------
Q
--------D
C
-----
P
K
A--R
R
E
V
E
L
H
-----
W
RAS-----QC
P
H
I
V
R
I
V
D
V
Y
E
N
L
YAG
R
K
C
L
L
I
V
M
E
CL
D
G
G
E
L
F
S
R
I
Q
DRGD
Q
--
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
SINIAHRDVKPEN
L
L
Y
TSKRP
N
A
I
L
K
LTDFGFAKETTSHNS-LTTPCYTPYYV
A
P
E
VL
G
P
E
K
YDKSCD
M
W
S
L
G
V
I
M
Y
I
L
LCGYPPFYS-NH
G
L
A
ISPGMK
T
--
R
I
RMGQYEFPNP
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
LKTEPTQ
R
M
T
I
T
E
FMNHP
W
I
MQ-STKV-----P--------QTPL
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
E
Q
I
K
I
K
K
IEDASN
P
L
L
L
K
R
R
K
K
A
R
A
L
E
A
A
ALAH
19
PsiBlast_PDB
83.15
99%
-124
- C1 -
3KA0
1
MAPK2_HUMAN
A:
[1-318]
----------------------------------------------
H
V
K
S
G
L
Q
I
--
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
-------
Q
--------
D
C
-----
P
K
A
--
R
R
E
V
E
L
H
-----
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
--------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
-------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
----------
G
M
K
T
--
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
-----
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
8
PsiBlast_PDB
78.90
100%
-116
- C1 -
3FYK
1
MAPK2_HUMAN
X:
[1-320]
--------------------------------------------
Q
F
H
V
K
S
G
L
Q
I
--
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
-------
Q
--------
D
C
-----
P
K
A
--
R
R
E
V
E
L
H
-----
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
--
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
S
-----------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
-----
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
69
PsiBlast_CBE
78.60
100%
-108
- C1 -
2PZY
1
MAPK2_HUMAN
C:
[2-319]
-----------------------------------------
Q
F
P
Q
F
H
V
K
S
G
L
Q
I
--
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
-------
Q
--------
D
C
-----
P
K
A
--
R
R
E
V
E
L
H
-----
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
--
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-
N
H
G
L
A
I
S
P
G
M
K
T
--
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
-----
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
-----------------------------------------
3
PsiBlast_PDB
77.76
100%
-122
- C1 -
1NY3
1
MAPK2_HUMAN
A:
[46-345]
---------------------------------------------
F
H
V
K
S
G
L
Q
I
--
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
-------
Q
--------
D
C
-----
P
K
A
--
R
R
E
V
E
L
H
-----
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
--------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
S
H
----------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
---------
G
M
K
T
--
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
-----
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------
128
HHSearch
77.75
100%
-114
- C1 -
1NXK
1
MAPK2_HUMAN
A:
[42-345]
-----------------------------------------
Q
F
P
Q
F
H
V
K
S
G
L
Q
I
--
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
-------
Q
--------
D
C
-----
P
K
A
--
R
R
E
V
E
L
H
-----
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
-----
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-
N
H
G
L
A
I
S
P
G
M
K
T
--
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
-----
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------
6
PsiBlast_PDB
77.56
100%
-115
- C1 -
2P3G
1
MAPK2_HUMAN
X:
[1-320]
--------------------------------------------
Q
F
H
V
K
S
G
L
Q
I
--
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
-------
Q
--------
D
C
-----
P
K
A
--
R
R
E
V
E
L
H
-----
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
--
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
S
-----------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
-----
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
70
PsiBlast_CBE
77.33
100%
-117
- C1 -
2PZY
1
MAPK2_HUMAN
B:
[4-305]
-------------------------------------------
P
Q
F
H
V
K
S
G
L
Q
I
--
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
-------
Q
--------
D
C
-----
P
K
A
--
R
R
E
V
E
L
H
-----
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
--
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
---------
G
M
K
T
--
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
-----
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------
9
PsiBlast_PDB
77.12
97%
-114
- C1 -
1NXK
1
MAPK2_HUMAN
A:
[42-345]
-----------------------------------------
Q
F
P
Q
F
H
V
K
S
G
L
Q
I
--
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
-------
Q
--------
D
C
-----
P
K
A
--
R
R
E
V
E
L
H
-----
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
-----
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-
N
H
G
L
A
I
S
P
G
M
K
T
--
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
-----
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------
18
PsiBlast_PDB
77.02
100%
-123
- C1 -
3R2Y
1
MAPK2_HUMAN
A:
[1-300]
---------------------------------------------
F
H
V
K
S
G
L
Q
I
--
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
-------
Q
--------
D
C
-----
P
K
A
--
R
R
E
V
E
L
H
-----
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
--------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
--------------------------
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
-----------
M
K
T
--
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
-----
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------
130
HHSearch
76.45
100%
-104
- C1 -
3M2W
1
MAPK2_HUMAN
A:
[3-299]
----------------------------------------------
H
V
K
S
G
L
Q
I
--
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
-------
Q
--------
D
C
-----
P
K
A
--
R
R
E
V
E
L
H
-----
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
--
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
----------------------
G
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
--------
P
G
M
K
T
--
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
-----
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
74
PsiBlast_CBE
76.18
93%
-110
- C1 -
3KGA
1
MAPK2_HUMAN
A:
[3-299]
----------------------------------------------
H
V
K
S
G
L
Q
I
--
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
-------
Q
--------
D
C
-----
P
K
A
--
R
R
E
V
E
L
H
-----
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
--
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
G
----------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
--------
P
G
M
K
T
--
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
-----
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
72
PsiBlast_CBE
75.67
93%
-109
- C1 -
3M42
1
MAPK2_HUMAN
A:
[3-299]
----------------------------------------------
H
V
K
S
G
L
Q
I
--
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
-------
Q
--------
D
C
-----
P
K
A
--
R
R
E
V
E
L
H
-----
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
--
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
G
----------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
--------
P
G
M
K
T
--
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
-----
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
13
PsiBlast_PDB
75.25
100%
-115
- C1 -
2PZY
1
MAPK2_HUMAN
A:
[2-306]
-----------------------------------------
Q
F
P
Q
F
H
V
K
S
G
L
Q
I
--
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
-------
Q
--------
D
C
-----
P
K
A
--
R
R
E
V
E
L
H
-----
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
-----
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-
N
H
G
L
A
I
S
P
G
M
K
T
--
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
-----
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
------------------------------------------------------
73
PsiBlast_CBE
75.10
93%
-104
- C1 -
3M2W
1
MAPK2_HUMAN
A:
[3-299]
----------------------------------------------
H
V
K
S
G
L
Q
I
--
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
-------
Q
--------
D
C
-----
P
K
A
--
R
R
E
V
E
L
H
-----
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
--
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
G
----------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
--------
P
G
M
K
T
--
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
-----
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
7
PsiBlast_PDB
74.44
100%
-108
- C1 -
3FYJ
1
MAPK2_HUMAN
X:
[1-320]
--------------------------------------------
Q
F
H
V
K
S
G
L
Q
I
--
K
K
N
A
I
I
D
D
Y
K
V
T
S
-
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
-------
Q
--------
D
C
-----
P
K
A
--
R
R
E
V
E
L
H
-----
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
--
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
S
-----------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
-----
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
77
PsiBlast_CBE
72.63
76%
-109
- C1 -
3SHE
1
MAPK3_HUMAN
A:
[3-316]
--------------------------------------------------------
K
K
Y
A
V
T
D
D
Y
Q
L
S
K
-
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
-------
Y
--------
D
S
-----
P
K
A
--
R
Q
E
V
D
H
H
-----
W
Q
A
S
-----
G
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
G
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
------
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
A
K
E
T
------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
Y
-----------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
I
N
Q
-
S
M
V
V
-----
P
--------
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
-------------------------------
78
PsiBlast_CBE
72.18
76%
-105
- C1 -
3R1N
1
MAPK3_HUMAN
A:
[3-316]
--------------------------------------------------------
K
K
Y
A
V
T
D
D
Y
Q
L
S
K
-
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
-------
Y
--------
D
S
-----
P
K
A
--
R
Q
E
V
D
H
H
-----
W
Q
A
S
-----
G
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
G
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
G
----
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
A
K
E
T
T
----------------------
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
Y
-----------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
I
N
Q
-
S
M
V
V
-----
P
--------
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
-------------------------------
129
HHSearch
72.10
77%
-109
- C1 -
3FHR
1
MAPK3_HUMAN
A:
[21-336]
-----------------------------------------------------
P
--
K
K
Y
A
V
T
D
D
Y
Q
L
S
K
-
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
-------
Y
--------
D
S
-----
P
K
A
--
R
Q
E
V
D
H
H
-----
W
Q
A
S
-----
G
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
G
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
-
D
Q
--
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
A
K
E
T
------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
I
N
Q
-
S
M
V
V
-----
P
--------
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
V
------------------------------
76
PsiBlast_CBE
70.84
74%
-108
- C1 -
3FHR
1
MAPK3_HUMAN
A:
[20-336]
------------------------------------------------------EP
K
K
Y
A
V
T
D
D
Y
Q
L
S
K
-
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
-------
Y
--------
D
S
-----
P
K
A
--
R
Q
E
V
D
H
H
-----
W
Q
A
S
-----
G
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
G
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
-
D
Q
--
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
A
K
E
T
------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
I
N
Q
-
S
M
V
V
-----
P
--------
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
V
------------------------------
75
PsiBlast_CBE
69.80
74%
-111
- C1 -
3FXW
1
MAPK3_HUMAN
A:
[20-336]
------------------------------------------------------EP
K
K
Y
A
V
T
D
D
Y
Q
L
S
K
-
Q
V
L
G
L
G
V
-
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
-------
Y
--------
D
S
-----
P
K
A
--
R
Q
E
V
D
H
H
-----
W
Q
A
S
-----
G
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
G
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
-
D
Q
--
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
A
K
E
-------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
I
N
Q
-
S
M
V
V
-----
P
--------
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
V
------------------------------
105
PsiBlast_CBE
52.68
35%
-110
- C1 -
3HZT
9
?
A:
[12-287]
------------------------------------------------------------------------
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
-------
K
KSSVTTTS
N
S
-----
G
A
L
--
L
D
E
V
A
V
------
L
K
Q
L
-----
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
--
Q
--
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
R
D
A
L
I
K
I
V
D
F
G
L
S
A
H
F
E
V
G
---------
T
A
Y
Y
I
A
P
E
V
L
-
R
K
K
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
-----
G
G
Q
T
D
Q
E
I
L
K
--
R
V
E
K
G
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
A
E
E
A
L
N
H
P
W
I
V
K
-
F
C
S
Q
-----------------
V
G
---------------
K
H
A
L
T
G
A
L
G
N
M
K
K
F
Q
S
S
Q
K
L
A
Q
A
A
M
L
F
M
G
S
K
L
T
T
L
E
E
T
K
E
L
T
Q
I
F
R
Q
L
146
HHSearch
52.06
40%
-128
- C1 -
2W4O
1
KCC4_HUMAN
A:
[48-313]
---------------------------------------------------------
R
D
A
L
S
D
F
F
E
V
E
--
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
-------
K
--------
K
--------------
I
G
V
L
-----
L
R
L
------
S
H
P
N
I
I
K
L
K
E
I
F
E
----
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
----
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
P
D
A
P
L
K
I
A
D
F
-----------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
-
E
R
G
D
Q
---
F
M
F
R
--
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
-
K
A
A
N
-----
F
--------
V
H
M
D
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
--------------------------------------
106
PsiBlast_CBE
48.29
37%
-117
- C1 -
2WEI
1
?
A:
[29-282]
-----------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
KASAKN
K
--------
D
T
-----
S
T
I
--
L
R
E
V
E
L
L
-----
K
K
L
D
-----
H
-
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
--
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
K
-
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
E
Y
D
I
L
K
------
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
-
Y
S
S
E
----------------------------------------------------------------------------------
88
PsiBlast_CBE
47.71
38%
-118
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[24-289]
----------------------------------------------------------------------
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
-------
A
--------
K
E
----------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
--
G
G
H
--
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
----
D
A
K
L
F
E
--
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
-
D
T
A
L
-----
D
--------
K
N
-
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
---------------------------------------------------
104
PsiBlast_CBE
47.35
33%
-86
- C1 -
3IGO
8
?
A:
[29-356]
-----------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
KASAKN
K
---------
T
-----
S
T
I
--
L
R
E
V
E
L
L
-----
K
K
L
D
-----
H
-
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
--
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
--------
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
E
Y
D
I
L
K
------
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
-----
P
T
ISD
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
86
PsiBlast_CBE
46.79
38%
-121
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[24-277]
----------------------------------------------------------------------
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
-------
A
------------------------
S
M
E
-----
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
--
G
G
H
--
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
G
L
S
K
M
E
D
P
G
---------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
----
D
A
K
L
F
E
--
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
----------------------------------------------------------------------------------------
87
PsiBlast_CBE
46.78
38%
-113
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[24-289]
----------------------------------------------------------------------
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
-------
A
--------
K
-----------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
--
G
G
H
--
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
G
-------
G
S
V
-
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
----
D
A
K
L
F
E
--
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
-
D
T
A
L
-----
D
--------
K
N
-
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
---------------------------------------------------
136
HHSearch
45.58
36%
-115
- C1 -
3C0I
1
CSKP_HUMAN
A:
[21-293]
-----------------------------------------------------------
L
F
E
D
V
Y
E
L
C
--
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
-------
D
V
A
K
F
T
---
S
S
PGLS
T
E
D
L
--
K
R
E
A
S
I
C
-----
H
M
L
------
K
H
P
H
I
V
E
L
L
E
T
Y
S
----
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
K
-----
E
R
L
F
E
--
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
-
R
D
R
Y
-----
A
--------
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
------------------------------------------------
102
PsiBlast_CBE
44.63
33%
-89
- C1 -
3NCG
1
?
A:
[29-356]
-----------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
KASAKN
K
--------
D
T
-----
S
T
I
--
L
R
E
V
E
L
L
-----
K
K
L
D
-----
H
-
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
--
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
------
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
E
Y
D
I
L
K
------
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
-----
P
T
ISD
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
90
PsiBlast_CBE
44.62
38%
-116
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[25-289]
-----------------------------------------------------------------------
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
-------
A
--------
K
E
----------------
E
-----
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
--
G
G
H
--
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
-------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
----
D
A
K
L
F
E
--
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
-
D
T
A
L
-----
D
--------
K
N
-
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
------------------------------------
101
PsiBlast_CBE
44.50
33%
-86
- C1 -
4Y5Q
1
?
A:
[29-356]
-----------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
KASAKN
K
--------
D
T
-----
S
T
I
--
L
R
E
V
E
L
L
-----
K
K
L
D
-----
H
-
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
--
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
----
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
E
Y
D
I
L
K
------
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
-----
P
T
ISD
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
147
HHSearch
44.05
32%
-117
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[78-348]
---------------------------------------------------
V
T
A
--
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
-------
K
--------
T
R
G
M
K
D
K
E
E
V
--
K
N
E
I
S
V
M
-----
N
Q
L
------
D
H
A
N
L
I
Q
L
Y
D
A
F
E
----
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
-
Y
--
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
-
D
A
K
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
K
-
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
-
D
N
D
A
----
E
T
L
N
--
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
-
H
K
L
H
-----
S
--------
R
L
S
A
Q
---------------------------------------------------------------
89
PsiBlast_CBE
43.58
38%
-116
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[25-289]
-----------------------------------------------------------------------
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
-------
A
--------
K
------------------------
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
--
G
G
H
--
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
----------
V
-
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
----
D
A
K
L
F
E
--
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
-
D
T
A
L
-----
D
--------
K
N
-
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
------------------------------------
91
PsiBlast_CBE
43.41
37%
-104
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[15-289]
----------------------------------------------------------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
-------
K
--------
K
S
--------------
S
L
E
N
E
I
A
V
L
K
K
I
-----
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
----
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
K
I
M
I
T
D
F
G
L
S
K
-
M
E
Q
N
G
I
-
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
-
E
----
T
E
S
K
L
F
E
--
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
-
N
T
A
L
HRDI
Y
P
--------
S
V
S
L
Q
I
Q
K
N
F
A
K
--------------------------------------------------------
100
PsiBlast_CBE
42.88
34%
-116
- C1 -
3KN5
1
KS6A5_HUMAN
A:
[11-291]
---------------------------------------------------------------
D
L
D
L
K
D
-
K
P
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
-------
S
--------
K
R
-----
M
E
A
N
T
Q
K
E
I
T
A
L
-----
K
L
C
E
-----
G
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
----
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
--
K
--
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
----
L
E
I
K
I
I
D
F
G
F
A
R
L
K
P
P
----------------------
N
G
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
-------
C
T
S
A
V
E
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
M
S
G
L
R
Y
N
E
W
L
Q
D
-
G
S
Q
L
-----
S
--------
S
N
P
L
M
T
P
D
I
L
G
S
S
G
A
A
V
H
T
C
V
K
A
T
F
H
A
F
N
K
Y
K
R
E
G
---------------------------------
92
PsiBlast_CBE
42.88
37%
-103
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[15-290]
----------------------------------------------------------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
-------
K
--------
K
S
--------------
S
L
E
N
E
I
A
V
L
K
K
I
-----
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
----
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
K
I
M
I
T
D
F
G
L
S
K
-
M
E
Q
N
G
I
-
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
-
E
----
T
E
S
K
L
F
E
--
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
-
N
T
A
L
HRDI
Y
P
--------
S
V
S
L
Q
I
Q
K
N
F
A
K
S
-------------------------------------------------------
103
PsiBlast_CBE
42.33
33%
-89
- C1 -
3MWU
1
?
A:
[29-356]
-----------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
KASAKN
K
--------
D
T
-----
S
T
I
--
L
R
E
V
E
L
L
-----
K
K
L
D
-----
H
-
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
--
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
-----
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
E
Y
D
I
L
K
------
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
-----
P
T
ISD
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
99
PsiBlast_CBE
39.66
34%
-108
- C1 -
3KN5
1
B:
[11-291]
---------------------------------------------------------------
D
L
D
L
K
D
-
K
P
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
-------
S
--------
K
R
-----
M
E
A
N
T
Q
K
E
I
T
A
L
-----
K
L
C
E
-----
G
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
----
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
--
K
--
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
----
L
E
I
K
I
I
D
F
G
F
A
R
L
K
P
P
----------------------
N
G
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
S
H
D
R
S
L
T
C
T
S
A
V
E
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
M
S
G
L
R
Y
N
E
W
L
Q
D
-
G
S
Q
L
-----
S
--------
S
N
P
L
M
T
P
D
I
L
G
S
S
G
A
A
V
H
T
C
V
K
A
T
F
H
A
F
N
K
Y
K
R
E
G
---------------------------------