@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SBK2_HUMAN: (2015-10-18 )
MPGKQSEEGPAEAGASEDSEEEGLGGLTLEELQQGQEAARALEDMMTLSAQTLVRAEVDELYEEVRPLGQGCYGRVLLVTHRQKGTPLALKQLPKPRTSLRGFLYEFCVGLSLGAHSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHARGLVYRDLKPENVLVCDPACRRFKLTDFGHTRPRGTLLRLAGPPIPYTAPELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPRDRPQPWFGLAAAADALLRGLLDPHPRRRSAVIAIREHLGRPWRQREGEAEAVGAVEEEAGQ
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------.........10........20........30....------....40........50........60-........70........80........90......---..100.........110...--....120.......130.......140.......150-.--------------------------------...--------....160.......170.......180.......190.......200...-----...--.210---.-----........220.......230.......240.......250.......260.......270.......280.......290.......300.......310...-----....320....------------------...330.......340......----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------MPGKQSEEGPAEAGASEDSEEEGLGGL
T
L
E
E
L
Q
Q
G
------
Q
E
A
A
R
A
L
E
D
M
M
T
L
S
A
Q
T
L
V
R
A
E
V
D
E
L
-
Y
E
E
V
R
P
LGQGCY
G
R
V
L
L
V
T
HRQKGT
P
L
A
L
K
QLPK
P
R
---
T
S
L
--
R
G
F
L
Y
E
F
C
V
GLSLGA--H
S
A
I
V
T
A
YGIGIESAHSYSFLTEPVL
H
G
D
L
M
A
F
IQP--K--------------------------------VGL--------P
Q
P
A
V
H
R
C
A
A
Q
L
A
S
A
L
E
Y
I
H
ARG
L
V
Y
RDLKPE
N
V
L
V
CDPAC
R
R
F
K
LTDFG-----HTR--PR-----G-----
T
L
L
R
LAGPPIPYTAPELCAPPPLPEGLPIQ
P
A
L
D
A
W
A
L
G
V
L
L
F
C
L
L
TGYFPWDRPLAEAD
P
F
Y
E
D
F
L
I
W
QASGQPRDRPQ
P
W
F
G
L
A
A
A
A
D
A
L
L
R
G
L
LDPHPRR
R
-----
S
A
V
I
A
I
R
E
HLG------------------R
P
W
R
QREGEA
E
A
VGA
V
E
E
EAGQ----------------------------
9
PsiBlast_PDB
73.98
30%
-111
- C1 -
2HXL
1
CHK1_HUMAN
A:
[6-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
------C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
K
R
P
--------------------------------------
13
PsiBlast_PDB
73.00
30%
-110
- C1 -
4QYE
1
CHK1_HUMAN
A:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------
44
HHSearch
71.96
25%
-107
- C1 -
3HKO
2
?
A:
[22-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
L
Q
K
K
-
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q
K
D
V
--
E
R
I
K
T
E
V
R
L
M
K
K
L
-
H
--
H
P
N
I
A
R
L
Y
E
V
-
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
--
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SI--
F
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
N
K
S
F
E
I
K
L
V
D
F
G
-----
L
S
K
--
E
F
YKLNN
G
-----------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
T
----
N
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
-----
D
A
D
T
I
S
Q
V
L
N
K
K
-
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
-----
F
D
A
M
R
A
L
Q
---------------------
H
P
W
I
S
Q
F
S
D
K
I
Y
K
M
S
-----------------------------------
1
PsiBlast_PDB
71.76
30%
-111
- C1 -
4FT3
6
CHK1_HUMAN
A:
[6-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
----------
E
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------
3
PsiBlast_PDB
71.75
30%
-114
- C1 -
2R0U
1
CHK1_HUMAN
A:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------
15
PsiBlast_PDB
71.48
30%
-104
- C1 -
4QYG
1
CHK1_HUMAN
A:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
-----------------------------------------
4
PsiBlast_PDB
71.40
30%
-109
- C1 -
2QHM
1
CHK1_HUMAN
A:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------
19
PsiBlast_PDB
71.02
30%
-107
- C1 -
4RVM
1
CHK1_HUMAN
A:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
-----------------------------------------
14
PsiBlast_PDB
70.93
30%
-110
- C1 -
4QYF
1
CHK1_HUMAN
A:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
P
R
V
T
S
------------------------------------
10
PsiBlast_PDB
70.90
30%
-108
- C1 -
2HXQ
1
CHK1_HUMAN
A:
[6-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
------C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
K
R
P
--------------------------------------
8
PsiBlast_PDB
70.79
30%
-114
- C1 -
2HOG
1
CHK1_HUMAN
A:
[6-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------
18
PsiBlast_PDB
70.73
30%
-112
- C1 -
4RVL
1
CHK1_HUMAN
A:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
------
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
-----------------------------------------
6
PsiBlast_PDB
70.02
30%
-115
- C1 -
3TKH
1
CHK1_HUMAN
A:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
-------------
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------
17
PsiBlast_PDB
69.18
30%
-107
- C1 -
4RVK
1
CHK1_HUMAN
A:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
-----------------------------------------
11
PsiBlast_PDB
69.11
30%
-114
- C1 -
2HY0
1
CHK1_HUMAN
A:
[6-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------
40
Fugue
67.79
22%
-85
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
KARKGKSKK
W
R
Q
M
L
QFPHISQC
E
E
L
R
L
S
LERD
Y
H
S
L
C
ERN
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
TPDDK
R
K
A
C
G
R
N
L
T
Q
N
FLSHTGPDL
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
---
I
K
K
--
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
MG
Q
--------------------------------
A
G
F
--------
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
--
H
I
R
I
S
D
L
G
-----
L
A
V
H
V
P
E
-----
G
-----
Q
T
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
------
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
---
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
---
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
LGCRG
G
S
A
R
E
V
K
E
H
P
L
FKKLN
F
K
R
L
G
A
GMLEPPF
K
P
D
P
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
GSVP
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
VFGLDGS
16
PsiBlast_PDB
67.76
30%
-106
- C1 -
4QYH
1
CHK1_HUMAN
A:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
-----------------------------------------
7
PsiBlast_PDB
67.48
30%
-111
- C1 -
3TKI
1
CHK1_HUMAN
A:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------
2
PsiBlast_PDB
67.38
30%
-115
- C1 -
4GH2
4
CHK1_HUMAN
A:
[6-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
-------------
N
I
K
K
E
I
C
I
N
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
--
N
L
K
I
S
D
F
G
LATVF
R
Y
N
--
N
R
-----
E
-----
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
----
R
R
E
F
H
A
E
P
-
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
-
S
D
S
C
Q
E
Y
S
D
---
W
K
---
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
------------------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------
41
HHSearch
64.68
29%
-105
- C1 -
2YEX
8
CHK1_HUMAN
A:
[4-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
V
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
AV-
D
C
P
--
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
--
H
E
N
V
V
K
F
Y
G
H
-
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
--
D
--------------------------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
--
D
N
L
K
I
S
D
F
G
-----
L
A
T
--
V
F
-----
R
YNN
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
-----
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
----
S
C
Q
E
Y
S
D
W
K
E
K
K
---
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
---
K
------------------
D
R
W
Y
N
K
P
L
K
-----------------------------------------