@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0412: (2015-12-01 )
MTNQTVRGTKDLLFDEWYRFKYIQQIANRISSLYGFLPAQTPIFEYTEVFMKTLGDGSDIINKEMYTFYDKGGKSITLRPEFTAAIVRLLVEKKLQIPIKLFSTGPAFRYERPQKGRQRQFHQINFEVFGVENPKADIELISLAHHLLTEFNISKNVRLEINSLGDSETIAKYKEVLIPYFKKFQNDLSEDSQNRLTKNPLRILDSKDEKDKLIISDAPKISDYYTRESSDFFEQILNGLTALNIPCTVNSKLVRGLDYYCHTVFEFVIEDFGAQGAVFAGGRYDNLVSSVGGKYTPAIGFAGGIERIMELINYSMKGDRPICLVPIGREAEEHALTLANELRRNGLYVIYEYNGALKNRMKKASQANAKAALIFGNEELGSKTLKIKNMDTGEEKIIAYGNIMENIHQTLLV
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90...----.---.----.---..100.......110.......120.......130.......140.......150.......160.......170.----......180.......190.......200.......210.....--..220.......230.......240.......250.......260.......270---......---.280.......290.......300...-----...---.310--......-----..320...---......330.......340...--....350.-..-.-...360.....---..370.......380.......390.......400.......410.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTNQTVRG
T
K
D
L
L
F
D
E
W
Y
R
F
K
Y
I
Q
Q
I
A
N
R
I
S
S
L
Y
GFLPAQT
P
I
F
E
Y
T
E
V
F
M
K
TLGD
G
S
D
I
I
N
K
E
M
Y
T
F
YDKGG
K
S
I
T
LR
P
E
F
T
A
A
I
V
R
L
L
V
E
KK----L---Q----
I
---
P
I
K
L
FSTGPAFRYERPQKGRQR
Q
F
H
Q
I
N
F
E
V
F
GVENPKA
D
I
E
L
I
S
L
A
H
H
L
L
T
E
FNISK
N
V
R
L
E
I
NSLG
D
S
E
T
I
A
K
Y
----
K
E
V
L
I
P
Y
F
K
K
F
Q
N
DLSE
D
S
Q
NRLTKN
P
L
R
ILDSKDEKD
K
L
I
ISD--APKI
S
D
YYTRE
S
S
D
F
F
E
Q
I
L
N
G
L
TALNIPCT
V
N
S
K
L
V
R
G
L
D
Y
Y
C
H
T
V
F
E
F
V
I
E
DF---GAQG
A
V
---
F
AGG
R
Y
D
N
L
V
S
S
VGGKYTPAIGF
A
G
G
I
-----
E
R
I
---
M
E
L
---
I
N
YSMK-----GDR--
P
I
C
---
L
V
PIGRE
A
E
E
H
A
L
T
L
A
N
E
L
RRN--
G
L
Y
V
I
Y
EY-N
G
-
A
-
L
K
N
R
M
K
K
A
SQA---NA
K
A
A
L
I
FGNEELGS
K
T
L
K
I
K
NMDTGE
E
K
I
I
A
Y
G
N
I
M
E
N
I
H
Q
T
LLV
39
HHSearch
94.32
39%
-108
- C2 -
1HTT
2
SYH_ECOLI
A:
[3-422]
-
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
---------------------------------------------------------
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
-------
Q
G
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
---
V
Q
A
V
N
P
EFKAD
P
V
V
--
D
I
Y
---
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
M
T
N
H
-
G
G
G
N
-
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
T
L
L
G
-
23
PsiBlast_CBE
93.87
39%
-109
- C2 -
1HTT
2
SYH_ECOLI
B:
[5-422]
---
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
------------------------------------------------------------------
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
-------
Q
G
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
V
Q
A
V
N
P
E
F
K
-----
A
D
---
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
M
T
N
H
-
G
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
-
R
T
L
L
G
41
HHSearch
93.65
39%
-109
- C2 -
1QE0
-
SYH_STAAU
A:
[1-419]
-
M
I
K
I
P
R
G
T
Q
D
I
L
P
E
D
S
K
K
W
R
Y
I
E
N
Q
L
D
E
L
M
T
F
Y
N
Y
K
E
I
R
T
P
I
F
E
S
T
D
L
F
A
R
-----------
E
M
Y
T
F
K
D
K
G
D
R
S
I
T
L
R
P
E
G
T
A
A
V
V
R
S
Y
I
E
H
K
MQGN
P
---
N
----
Q
---
P
I
K
L
Y
Y
N
G
P
M
F
R
Y
-------
Y
R
Q
F
N
Q
F
G
V
E
A
I
G
A
E
N
P
S
V
D
A
E
V
L
A
M
V
M
H
I
Y
Q
S
F
G
L
K
-
H
L
K
L
V
I
N
S
V
G
D
M
A
S
R
K
E
Y
----
N
E
A
L
V
K
H
F
E
P
V
I
H
E
F
C
S
D
C
Q
S
R
L
H
T
D
P
M
R
I
L
------------
T
--
A
P
R
I
T
D
F
L
N
E
E
S
K
A
Y
Y
E
Q
V
K
A
Y
L
D
D
L
G
I
P
Y
T
E
D
P
N
L
V
R
G
L
D
Y
Y
T
H
T
A
F
E
L
M
M
D
N
P
NYD
G
A
I
T
T
L
---
C
G
G
G
R
Y
N
G
L
L
E
L
L
D
G
P
S
E
T
G
I
G
F
A
L
S
I
-----
E
R
L
---
L
L
A
---
L
E
E
E
G
I
ELDIE
E
N
L
--
D
L
F
---
I
V
T
M
G
D
Q
A
D
R
Y
A
V
K
L
L
N
H
L
R
H
N
--
G
I
K
A
D
K
D
Y
-
L
Q
R
K
-
I
K
G
Q
M
K
Q
A
D
R
L
---
G
A
K
F
T
I
V
I
G
D
Q
E
L
E
N
N
K
I
D
V
K
N
M
T
T
G
E
S
E
T
I
E
L
D
A
L
V
E
Y
F
K
K
----
22
PsiBlast_CBE
93.18
39%
-109
- C2 -
1HTT
2
SYH_ECOLI
C:
[5-422]
---
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
---------------------------------------------------------
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
-------
Q
G
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
VQA
V
N
P
E
F
K
-----
A
D
---
P
V
V
DIY
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
LP
G
V
K
L
M
T
N
H
-
G
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
-
R
T
L
L
G
40
HHSearch
93.12
39%
-108
- C2 -
1H4V
1
SYH_THET2
B:
[2-420]
-
T
A
R
A
V
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
------
K
E
M
F
T
F
Q
D
R
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
----
M
KVW
P
----
Q
---
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
----
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
----
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
E
LG
V
R
P
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
---------
S
A
L
---
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
-----
E
R
V
---
A
L
A
---
L
E
A
E
G
F
GLPEE
K
G
P
--
D
L
Y
---
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
---
L
R
A
E
Y
A
L
-
A
P
R
K
-
P
A
K
G
L
E
E
A
L
K
R
---
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
Q
V
R
L
S
R
E
E
V
P
G
Y
L
L
Q
A
L
G
-
1
PsiBlast_PDB
92.93
39%
-107
- C2 -
1HTT
2
SYH_ECOLI
A:
[5-422]
---
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
---------------------------------------------------------
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
-------
Q
G
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
V
Q
A
V
N
P
E
F
K
-----
A
D
---
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
M
T
N
H
-
G
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
-
R
T
L
L
G
21
PsiBlast_CBE
92.86
39%
-110
- C2 -
1HTT
2
SYH_ECOLI
D:
[5-422]
---
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
------------------------------------------------------------------
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
-------
Q
G
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
VQA
V
N
P
E
F
K
-----
A
D
---
P
V
V
DIY
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
LP
G
V
K
L
M
T
N
H
-
G
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
-
R
T
L
L
G
3
PsiBlast_PDB
92.36
39%
-109
- C2 -
1KMN
2
SYH_ECOLI
A:
[6-423]
---
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
----
R
D
A
L
V
A
F
L
--------------------------------------------
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
---
G
S
Q
G
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
V
Q
A
V
N
P
E
F
K
-----
A
D
---
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
M
T
N
H
-
G
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
-
R
T
L
L
G
26
PsiBlast_CBE
92.26
39%
-109
- C2 -
1KMN
2
SYH_ECOLI
B:
[6-423]
---
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
----------------------------------------------------------------
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
---
G
S
Q
G
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
V
Q
A
V
N
P
E
F
K
-----
A
D
---
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
M
T
N
H
-
G
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
-
R
T
L
L
G
31
PsiBlast_CBE
92.25
39%
-106
- C2 -
2EL9
1
SYH_ECOLI
C:
[13-430]
---
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
----
R
D
A
-----------------------------------------------
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
--------
G
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
V
Q
A
V
N
P
E
F
K
-----
A
D
---
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
M
T
N
H
-
G
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
-
R
T
L
L
G
32
PsiBlast_CBE
92.16
39%
-108
- C2 -
2EL9
1
SYH_ECOLI
B:
[13-430]
---
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
----
R
-----------------------------------------------
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
---
G
S
Q
G
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
V
Q
A
V
N
P
E
F
K
-----
A
D
---
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
M
T
N
H
-
G
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
-
R
T
L
L
G
4
PsiBlast_PDB
92.03
39%
-109
- C2 -
2EL9
1
SYH_ECOLI
A:
[13-430]
---
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
----
R
D
----------------------------------------------
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
---------
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
V
Q
A
V
N
P
E
F
K
-----
A
D
---
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
M
T
N
H
-
G
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
-
R
T
L
L
G
28
PsiBlast_CBE
91.94
39%
-106
- C2 -
1KMM
1
SYH_ECOLI
C:
[6-423]
---
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
----
R
D
A
L
V
A
F
L
E
Q
H
------------------------------------
P
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
---
G
S
Q
G
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
V
Q
A
V
N
P
E
F
K
-----
A
D
---
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
M
T
N
H
-
G
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
-
R
T
L
L
G
27
PsiBlast_CBE
91.91
39%
-107
- C2 -
1KMM
1
SYH_ECOLI
D:
[6-423]
---
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
-----------------------------------------------------------------
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
---
G
S
Q
G
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
V
Q
A
V
N
P
E
F
K
-----
A
D
---
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
M
T
N
H
-
G
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
-
R
T
L
L
G
30
PsiBlast_CBE
91.73
39%
-104
- C2 -
2EL9
1
SYH_ECOLI
D:
[13-430]
---
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
----
R
D
A
L
V
A
F
L
E
Q
--------------------------------------
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
---
G
S
Q
G
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
VQA
V
N
P
E
F
K
-----
A
D
---
P
V
V
DIY
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
LP
G
V
K
L
M
T
N
H
-
G
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
-
R
T
L
L
G
24
PsiBlast_CBE
91.61
39%
-109
- C2 -
1KMN
2
SYH_ECOLI
D:
[6-423]
---
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
-----------------------------------------------------------------
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
---
G
S
Q
G
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
V
Q
A
V
N
P
E
F
K
-----
A
D
---
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
M
T
N
H
-
G
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
-
R
T
L
L
G
29
PsiBlast_CBE
91.30
39%
-106
- C2 -
1KMM
1
SYH_ECOLI
B:
[6-423]
---
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
-----------------------------------------------------------------
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
---
G
S
Q
G
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
V
Q
A
V
N
P
E
F
K
-----
A
D
---
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
M
T
N
H
-
G
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
-
R
T
L
L
G
5
PsiBlast_PDB
90.85
39%
-106
- C2 -
1QE0
-
SYH_STAAU
A:
[6-416]
------
R
G
T
Q
D
I
L
P
E
D
S
K
K
W
R
Y
I
E
N
Q
L
D
E
L
M
T
F
Y
N
Y
K
E
I
R
T
P
I
F
E
S
T
D
L
F
A
R
-----------
E
M
Y
T
F
K
D
K
G
D
R
S
I
T
L
R
P
E
G
T
A
A
V
V
R
S
Y
I
E
H
K
----
M
---
Q
GNPN
Q
---
P
I
K
L
Y
Y
N
G
P
M
F
R
Y
-------
Y
R
Q
F
N
Q
F
G
V
E
A
I
G
A
E
N
P
S
V
D
A
E
V
L
A
M
V
M
H
I
Y
Q
S
F
G
L
-
K
H
L
K
L
V
I
N
S
V
G
D
M
A
S
R
K
E
Y
----
N
E
A
L
V
K
H
F
E
P
V
I
H
E
F
C
S
D
C
Q
S
R
L
H
T
D
P
M
R
I
L
------------
T
--
A
P
R
I
T
D
F
L
N
E
E
S
K
A
Y
Y
E
Q
V
K
A
Y
L
D
D
L
G
I
P
Y
T
E
D
P
N
L
V
R
G
L
D
Y
Y
T
H
T
A
F
E
L
M
M
D
N
P
---
N
Y
D
G
A
I
TTL
C
G
G
G
R
Y
N
G
L
L
E
L
L
D
G
P
S
E
T
G
I
G
F
A
L
S
I
E
R
L
L
L
A
L
E
---
E
E
G
---
I
E
L
D
I
E
-----
E
N
L
--
D
L
F
---
I
V
T
M
G
D
Q
A
D
R
Y
A
V
K
L
L
N
H
L
R
H
N
--
G
I
K
A
D
K
D
Y
L
Q
R
-
K
-
I
K
G
Q
M
K
Q
A
D
R
L
---
G
A
K
F
T
I
V
I
G
D
Q
E
L
E
N
N
K
I
D
V
K
N
M
T
T
G
E
S
E
T
I
E
L
D
A
L
V
E
Y
F
K
K
----
2
PsiBlast_PDB
90.78
39%
-106
- C2 -
1KMM
1
SYH_ECOLI
A:
[6-423]
---
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
----
R
D
A
L
V
A
F
L
E
Q
H
-------------------------------------
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
---
G
S
Q
G
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
V
Q
A
V
N
P
E
F
K
-----
A
D
---
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
M
T
N
H
-
G
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
-
R
T
L
L
G
25
PsiBlast_CBE
90.73
39%
-105
- C2 -
1KMN
2
SYH_ECOLI
C:
[6-423]
---
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
----
L
LY-
N
----
Q
---
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
----
R
D
A
L
V
A
F
L
E
Q
H
------------------------------------
P
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
---
G
S
Q
G
T
V
---
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
-----
E
R
L
---
V
L
L
V
Q
A
V
N
P
E
F
K
-----
A
D
---
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
M
T
N
H
-
G
G
-
G
N
F
K
K
Q
F
A
R
A
D
K
W
---
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
-
R
T
L
L
G
8
PsiBlast_PDB
87.03
39%
-95
- C2 -
4RDX
2
SYH_THET2
A:
[4-406]
-
T
A
R
A
V
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
-----------
E
M
F
T
F
Q
D
R
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
----
M
---
K
----
V
WPQ
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
----
R
E
A
L
S
E
D
S
K
E
R
L
E
L
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
E
L
G
V
R
P
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
I
---
G
A
Q
S
A
L
---
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
-----
E
R
V
A
L
A
L
E
A
---
E
G
F
G
L
P
-----
E
E
K
GP
D
L
Y
---
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
-----
L
R
A
E
Y
-
A
L
-
A
-
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
Q
V
R
L
S
R
E
E
V
P
G
Y
L
L
Q
A
L
G
-