@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0443: (2015-12-01 )
MSAIAIIDFGSQFTQLIARQIREMDVYCEIFPSNISFETISKFNGFILSGGPQSVHDGCSEASGVAHEIIKFNEATNVPILGICYGQQLICHYFGAKVKKEFKQEFCKTKIKILKESSIVKDVWNVNSEVDVLMNHADSVETAPQGFTVIASGVINQTIAIVANEQRRIYCTQFHPEVKPTANGSKLLSNFLDIANCKRDWTMKSIIEKQKEKIKNVVGEKKVIAAVSGGVDSSVAVALTYKAVGKQLNCIFIDTGLLRKNQTIALLEEIPVNYVDKSNLFLSRLKGITDPEEKRKIIGNTFIEVFEEEAKKIGNADFLMQGTIYSDVVESGHASGNASTIKSHHNVGGLPEKMNLKLVEPLRYLFKDEVRLLGKEIGLSNEIIFQHPFPGPGLAVRVIGEVDEERVRILQEIDEIYINTMKNYDLYDKIWQAFAVLLPIRTVGVMGDGRTYGYVCALRAVTSFDGMTADAFPFENKSQHSLIFWDFLQNVSSIIVNNVSGVNRVVYDLTSKPPATIEWE
Atome Classification :
(20 SA)
----.........10........20........30........--40-..--..--.....50........60........70.....---...80........90........100.......110...-------------..-------------------------..---120..------------..-----..--------.-----130........140........150........160.......170.......180........190.-.-......200.......210.......220.......230.......240...-.-...250.......---260----.-------..----.------..--.------270----...--.--.....280.----------.----------.....290.......300......---.310-.---.---.----....320.......330-.--.--.....340.......350..--..--...360.......370.......380.......390.......400.-------......------------------------410.......420.....--..430..------------------.....440.......450......---------------------------------------------------------------------------------------------------------.460.......470..----.......480.......490.......500.......510.......520
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----M
S
A
I
A
I
I
D
F
G
S
Q
F
T
Q
L
I
A
R
Q
I
R
EM
D
V
Y
C
E
I
FPSNIS
F
E
T
--
I
--
S
K--FN--
G
F
I
LSGGP
Q
S
V
H
D
G
C
S
E
A
S
G
V
A
H
E
I
I
KFNEAT---NV
P
I
L
G
I
CY
G
Q
Q
L
I
C
H
Y
F
G
A
K
V
K
K
E
F
K
Q
E
F
C
K
T
K
I
K
I
LK-------------E
S
-------------------------
S
I
---
V
K
D
V
W------------NV-----NS--------
E
-----
V
D
-
V
L
M
NHADSV-ETAPQ
G
F
T
V
I
A
-SGVIN
Q
T
I
A
I
V
ANE
Q
R
R
I
Y
C
T
QFHPEVKP-TA
N
G
S
K
L
L
S
N
F
-
L
-
D
-
I
A
NCKRD
W
T
M
K
S
I
I
E
K
Q
K
E
K
I
K
N
V
VGEK
K
V
I
A
A
VSGGVDS
S
V
A
V
A
L
T
Y
K
A
VG-K-Q
L
N
C
I
F
IDTGLLR---KN
Q
----
T
-------
I
A
----
L
------
L
E
--E------I------PVN--Y--VDK
S
N
L
F
L
S
----------
R
----------LKGIT
D
P
E
E
K
R
K
I
I
G
N
T
F
I
E
V
F
E
E
---
E
A
K
K-I---G---N----A
D
F
L
M
QG
T
I
Y
S
D
V
V
ESG-H--A--SGN
A
S
T
I
K
SHHNVGGLPEKM--NL--
K
L
V
E
P
L
R
Y
L
F
K
D
E
V
R
L
L
G
K
E
IGLSN
E
I
I
F
QHPFPGP
G
L
A
V
R
V
IGEV
D
-------
E
E
R
V
R
I
------------------------
L
Q
E
I
D
E
I
Y
I
N
TMKNY
D
L
Y
--
D
K
I
W
Q
A
F
------------------
A
V
L
L
P
I
R
T
V
G
VMGDGR
T
Y
G
Y
V
C
A
L
---------------------------------------------------------------------------------------------------------
R
A
V
TSFDGMTAD--AF----PFENKSQH
S
L
I
F
W
D
F
L
Q
N
V
S
S
I
I
V
NNVS
G
V
N
R
V
V
Y
DLTSKPPATIEWE
53
HHSearch
94.32
49%
-123
- C2 -
3TQI
-
GUAA_COXBU
A:
[7-523]
----
Q
H
R
I
L
I
L
D
F
G
S
Q
Y
A
Q
L
I
A
R
R
V
R
E
I
G
V
Y
C
E
L
M
P
C
D
I
D
E
E
T
--
I
R
D
F
N
--
P
H
--
G
I
I
L
S
G
G
P
E
---------------
A
P
A
F
I
F
E
I
---
G
C
P
V
L
G
I
C
Y
G
M
Q
T
M
A
Y
Q
L
G
G
K
V
N
-----
E
F
G
H
A
Q
L
R
V
L
N
-------------
P
A
-------------------------------
F
L
F
D
------------
G
I
-----
E
D
QVSPQG
E
P
L
-----
L
D
-
V
W
M
S
H
G
D
I
V
-
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E
L
P
P
G
F
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A
T
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-
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T
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N
S
P
L
A
A
M
A
D
F
K
R
R
F
F
G
L
Q
F
H
P
E
V
T
H
-
T
P
Q
G
H
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L
A
H
F
-
V
I
H
-
I
C
Q
C
I
P
N
W
T
T
K
H
I
I
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R
D
I
Q
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K
V
G
K
E
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V
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V
G
L
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G
G
V
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A
T
L
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K
A
I
G
-
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L
V
C
V
L
V
D
T
G
L
L
R
---
L
N
E
----
V
-------
D
E
----
V
L
N
V
FQK
H
L
--
G
------
A
------
K
V
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--
C
--
V
D
A
K
D
R
F
M
K
----------
A
----------
L
K
G
I
S
D
P
E
E
K
R
K
I
A
G
E
Q
F
I
R
V
F
E
E
---
Q
A
K
K
-
L
-------
N
----
V
K
W
L
G
Q
G
T
I
Y
P
D
V
I
E
S
----------------------------------
K
L
I
E
P
L
R
E
L
F
K
D
E
V
R
K
L
G
L
E
L
G
L
P
A
D
L
I
Y
R
H
P
F
P
G
P
G
L
A
I
R
I
L
G
E
V
S
-------
A
E
Y
I
N
I
------------------------
L
K
Q
A
D
A
I
F
I
E
E
L
K
K
S
D
Y
Y
--
H
Q
V
S
Q
A
F
------------------
A
V
F
M
P
L
K
S
V
--------
Y
G
Y
I
I
A
L
---------------------------------------------------------------------------------------------------------
R
A
V
K
-------
Q
--
W
A
----
D
L
P
---------
H
E
F
L
S
K
V
S
H
R
I
V
N
E
I
K
E
V
S
R
V
V
Y
D
M
T
N
K
P
P
A
T
I
E
W
-
2
PsiBlast_PDB
94.24
47%
-132
- C2 -
3TQI
-
GUAA_COXBU
A:
[10-523]
-------
I
L
I
L
D
F
G
S
Q
Y
A
Q
L
I
A
R
R
V
R
E
I
G
V
Y
C
E
L
M
P
C
D
I
D
E
E
T
--
I
--
R
D
--
F
N
PH
G
I
I
L
S
G
G
P
E
--------
A
P
A
F
I
F
E
I
----------
G
C
P
V
L
G
I
C
Y
G
M
Q
T
M
A
Y
Q
L
G
G
K
V
N
-----
E
F
G
H
A
Q
L
R
V
L
N
-------------
P
A
-------------------------
F
L
FDG
I
E
D
Q
V
------------
S
P
-----
Q
G
--------
E
P
L
---
L
D
-
V
W
M
S
H
G
D
I
V
-
S
E
L
P
P
G
F
E
A
T
A
-
C
-
T
D
N
S
P
L
A
A
M
A
D
F
K
R
R
F
F
G
L
Q
F
H
P
E
V
T
H
-
T
P
Q
G
H
R
I
L
A
H
F
V
I
-
H
-
I
C
Q
C
I
P
N
W
T
T
K
H
I
I
E
D
S
I
R
D
I
Q
E
K
V
G
K
E
Q
V
I
V
G
L
S
G
G
V
D
S
A
V
T
A
T
L
V
H
K
A
I
G
-
D
-
Q
L
V
C
V
L
V
D
T
G
L
L
R
---
L
N
E
----
V
-------
D
E
----
V
------
L
N
--
V
------
F
QKHLG
A
K
V
I
--
C
--
V
D
A
K
D
R
F
M
K
----------
A
----------
L
K
G
I
S
D
P
E
E
K
R
K
I
A
G
E
Q
F
I
R
V
F
E
E
---
Q
A
K
K
-
L
-------
N
----
V
K
W
L
G
Q
G
T
I
Y
P
D
V
I
E
S
----------------------------------
K
L
I
E
P
L
R
E
L
F
K
D
E
V
R
K
L
G
L
E
L
G
L
P
A
D
L
I
Y
R
H
P
F
P
G
P
G
L
A
I
R
I
L
G
E
V
S
-------
A
E
Y
I
N
I
------------------------
L
K
Q
A
D
A
I
F
I
E
E
L
K
K
S
D
Y
Y
--
H
Q
V
S
Q
A
F
------------------
A
V
F
M
P
L
K
S
V
--------
Y
G
Y
I
I
A
L
---------------------------------------------------------------------------------------------------------
R
A
V
K
----------------------
Q
W
A
D
L
P
H
E
F
L
S
K
V
S
H
R
I
V
N
E
I
K
E
V
S
R
V
V
Y
D
M
T
N
K
P
P
A
T
I
E
W
-
4
PsiBlast_PDB
93.20
44%
-125
- C2 -
2YWC
1
GUAA_THET8
A:
[2-503]
-------
V
L
V
L
D
F
G
S
Q
Y
T
R
L
I
A
R
R
L
R
E
L
R
A
F
S
L
I
L
P
G
D
A
P
L
E
E
--
V
--
L
K
--
H
R
PQ
A
L
I
L
S
G
G
P
R
S
V
F
D
--
P
D
A
P
R
P
D
P
R
L
F
----
S
S
---
G
L
P
L
L
G
I
C
Y
G
M
Q
L
L
A
Q
E
L
G
G
R
V
E
R
A
G
R
A
E
Y
G
K
A
L
L
-
T
R
H
-------------
E
G
-------------------------
P
L
---
F
R
---------------
G
L
-----
E
G
--------
E
-----
V
Q
-
V
W
M
S
H
Q
D
A
V
-
T
A
P
P
P
G
W
R
V
V
A
-
E
T
E
E
N
-
P
V
A
A
I
A
S
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D
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R
A
Y
G
V
Q
F
H
P
E
V
A
H
-
T
P
K
G
M
Q
I
L
E
N
F
-
L
-
E
-
L
A
G
V
K
R
D
W
T
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E
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V
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L
L
R
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V
R
E
R
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V
L
L
A
V
S
G
G
V
D
S
S
T
L
A
L
L
L
A
K
A
-
G
-
V
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D
H
L
A
V
F
V
D
H
G
L
L
R
LG
E
R
E
E
----
V
-------
E
G
----
A
------
L
R
--
A
------
L
------
G
V
N
--
L
L
V
V
D
A
K
E
R
F
L
K
----------
A
----------
L
K
G
V
E
D
P
E
E
K
R
K
I
I
G
R
E
F
V
A
A
F
S
Q
---
V
A
R
E
-
R
---
G
---
P
----
F
R
F
L
A
Q
G
T
L
Y
P
D
V
I
E
----------------------
G
G
L
P
E
D
L
--
E
F
--
E
L
L
E
P
F
R
L
L
F
K
D
E
V
R
E
L
A
L
L
L
G
L
P
D
T
L
R
L
R
H
P
F
P
G
P
G
L
A
V
R
V
L
G
E
V
T
-------
E
E
R
L
E
I
------------------------
L
R
R
A
D
D
I
F
T
S
L
L
R
E
W
G
L
Y
--
E
K
V
A
Q
A
L
------------------
A
V
L
T
P
V
------------
G
Y
V
L
A
L
---------------------------------------------------------------------------------------------------------
R
A
V
T
T
E
D
F
M
T
A
D
WA
R
L
----
P
L
E
-----------
F
L
D
E
A
A
R
R
I
T
R
R
V
P
E
I
G
R
V
V
Y
D
L
T
S
K
P
P
A
T
I
E
W
E
3
PsiBlast_PDB
93.11
44%
-125
- C2 -
2YWB
-
GUAA_THET8
A:
[2-503]
-------
V
L
V
L
D
F
G
S
Q
Y
T
R
L
I
A
R
R
L
R
E
L
R
A
F
S
L
I
L
P
G
D
A
P
L
E
E
--
V
--
L
K
--
H
R
PQ
A
L
I
L
S
G
G
P
R
S
V
F
D
--
P
D
A
P
R
P
D
P
R
L
F
----
S
S
---
G
L
P
L
L
G
I
C
Y
G
M
Q
L
L
A
Q
E
L
G
G
R
V
E
R
A
---
E
Y
G
K
A
L
L
-
T
R
H
-------------
E
G
-------------------------
P
L
---
F
R
---------------
G
L
-----
E
G
--------
E
-----
V
Q
-
V
W
M
S
H
Q
D
A
V
-
T
A
P
P
P
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W
R
V
V
A
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T
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N
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P
V
A
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A
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L
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N
F
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L
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E
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L
A
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V
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V
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L
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R
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L
L
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V
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G
G
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A
L
L
L
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K
A
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-
V
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H
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A
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F
V
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G
L
L
R
LG
E
R
E
E
----
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-------
E
G
----
A
------
L
R
--
A
------
L
------
G
V
N
--
L
L
V
V
D
A
K
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R
F
L
K
----------
A
----------
L
K
G
V
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D
P
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R
K
I
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F
V
A
A
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---
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R
---
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----
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R
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L
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T
L
Y
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I
E
-----------------------
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L
P
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D
L
--
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F
--
E
L
L
E
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F
R
L
L
F
K
D
E
V
R
E
L
A
L
L
L
G
L
P
D
T
L
R
L
R
H
P
F
P
G
P
G
L
A
V
R
V
L
G
E
V
T
-------
E
E
R
L
E
I
------------------------
L
R
R
A
D
D
I
F
T
S
L
L
R
E
W
G
L
Y
--
E
K
V
A
Q
A
L
------------------
A
V
L
T
P
V
------------
G
Y
V
L
A
L
---------------------------------------------------------------------------------------------------------
R
A
V
T
T
E
D
F
M
T
A
D
WA
R
L
----
P
L
E
-----------
F
L
D
E
A
A
R
R
I
T
R
R
V
P
E
I
G
R
V
V
Y
D
L
T
S
K
P
P
A
T
I
E
W
E
52
HHSearch
92.68
47%
-115
- C2 -
1GPM
4
GUAA_ECOLI
A:
[7-525]
----
K
H
R
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
W
D
V
T
E
A
Q
--
I
R
D
F
N
--
P
S
--
G
I
I
L
S
G
G
P
E
S
T
T
E
E
--
N
S
P
R
A
P
-
Q
Y
V
---
F
E
A
---
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
R
E
F
G
Y
A
Q
V
E
V
V
N
-------------
D
S
-------------------------------
A
L
V
R
------------
G
I
-----
E
D
ALTADG
K
P
L
-----
L
D
-
V
W
M
S
H
G
D
K
V
-
T
A
I
P
S
D
F
I
T
V
A
-
S
T
-
E
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
-
T
R
Q
G
M
R
M
L
E
R
F
-
V
R
D
-
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
-
N
L
T
C
V
F
V
D
N
G
L
L
R
---
L
N
E
----
A
-------
E
Q
----
V
L
D
M
F
GD
H
F
--
G
------
L
------
N
I
V
--
H
--
V
P
A
E
D
R
F
L
S
----------
A
----------
L
A
G
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
---
E
A
L
K
L
E
-------
D
----
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
S
A
-
A
---------------------------
K
M
--
G
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
V
K
-------
K
E
Y
C
D
L
------------------------
L
R
R
A
D
A
I
F
I
E
E
L
R
K
A
D
L
Y
--
D
K
V
S
Q
A
F
------------------
T
V
F
L
P
V
R
S
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
---------------------------------------------------------------------------------------------------------
R
A
V
E
T
I
D
F
M
T
A
H
--
W
A
----
H
L
P
---------
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
1
PsiBlast_PDB
92.19
45%
-114
- C2 -
1GPM
4
GUAA_ECOLI
A:
[10-525]
-------
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
W
D
V
T
E
A
Q
--
I
--
R
D
--
F
N
PS
G
I
I
L
S
G
G
P
E
S
T
T
E
E
N
S
P
R
A
P
------
Q
Y
V
F
E
A
---
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
R
E
F
G
Y
A
Q
V
E
V
V
N
-------------
D
S
-------------------------
A
L
---
V
R
G
I
E
------------
D
A
-----
L
T
--------
A
DG
K
P
L
L
D
-
V
W
M
S
H
G
D
K
V
-
T
A
I
P
S
D
F
I
T
V
A
-
S
-
T
E
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
-
T
R
Q
G
M
R
M
L
E
R
F
-
V
R
D
-
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
-
N
L
T
C
V
F
V
D
N
G
L
L
R
---
L
N
E
----
A
-------
E
Q
----
V
------
L
D
--
M
F
GDHFG
L
------
N
I
V
--
H
--
V
P
A
E
D
R
F
L
S
----------
A
----------
L
A
G
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
---
E
A
L
K
-
L
---
E
---
D
----
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
S
A
A----------------------------
K
M
--
G
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
V
K
-------
K
E
Y
C
D
L
------------------------
L
R
R
A
D
A
I
F
I
E
E
L
R
K
A
D
L
Y
--
D
K
V
S
Q
A
F
------------------
T
V
F
L
P
V
R
S
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
---------------------------------------------------------------------------------------------------------
R
A
V
E
T
I
D
F
M
T
A
---------------
H
W
A
H
L
P
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
21
PsiBlast_CBE
92.01
45%
-118
- C2 -
1GPM
5
GUAA_ECOLI
D:
[10-525]
-------
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
W
D
V
T
E
A
Q
--
I
--
R
D
--
F
N
PS
G
I
I
L
S
G
G
P
E
S
T
T
E
E
N
S
P
R
A
P
------
Q
Y
V
F
E
A
---
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
R
E
F
G
Y
A
Q
V
E
V
V
N
-------------
D
S
-------------------------
A
L
---
V
R
G
I
E
------------
D
A
-----
L
T
--------
A
DGKPL
L
D
-
V
W
M
S
H
G
D
K
V
-
T
A
I
P
S
D
F
I
T
V
A
-
S
-
T
E
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
-
T
R
Q
G
M
R
M
L
E
R
F
-
V
R
D
-
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
-
N
L
T
C
V
F
V
D
N
G
L
L
R
---
L
N
E
----
A
-------
E
Q
----
V
------
L
D
--
M
FGDHFG
L
------
N
I
V
--
H
--
V
P
A
E
D
R
F
L
S
----------
A
----------
L
A
G
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
---
E
A
L
K
-
L
---
E
---
D
----
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
----------------------------
M
--
K
M
--
G
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
V
K
-------
K
E
Y
C
D
L
------------------------
L
R
R
A
D
A
I
F
I
E
E
L
R
K
A
D
L
Y
--
D
K
V
S
Q
A
F
------------------
T
V
F
L
P
V
R
S
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
---------------------------------------------------------------------------------------------------------
R
A
V
E
T
I
D
F
M
T
A
---------------
H
W
A
H
L
P
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
23
PsiBlast_CBE
91.82
45%
-115
- C2 -
1GPM
4
GUAA_ECOLI
B:
[10-525]
-------
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
W
D
V
T
E
A
Q
--
I
--
R
D
--
F
N
PS
G
I
I
L
S
G
G
P
E
S
T
T
E
E
N
S
P
R
A
P
------
Q
Y
V
F
E
A
---
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
R
E
F
G
Y
A
Q
V
E
V
V
N
-------------
D
S
-------------------------
A
L
---
V
R
G
I
E
------------
D
A
-----
L
T
--------
A
DG
K
P
L
L
D
-
V
W
M
S
H
G
D
K
V
-
T
A
I
P
S
D
F
I
T
V
A
-
S
-
T
E
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
-
T
R
Q
G
M
R
M
L
E
R
F
-
V
R
D
-
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
-
N
L
T
C
V
F
V
D
N
G
L
L
R
---
L
N
E
----
A
-------
E
Q
----
V
------
L
D
--
M
F
GDHFG
L
------
N
I
V
--
H
--
V
P
A
E
D
R
F
L
S
----------
A
----------
L
A
G
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
---
E
A
L
K
-
L
---
E
---
D
----
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
----------------------------
M
--
K
M
--
G
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
V
K
-------
K
E
Y
C
D
L
------------------------
L
R
R
A
D
A
I
F
I
E
E
L
R
K
A
D
L
Y
--
D
K
V
S
Q
A
F
------------------
T
V
F
L
P
V
R
S
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
---------------------------------------------------------------------------------------------------------
R
A
V
E
T
I
D
F
M
T
A
---------------
H
W
A
H
L
P
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
51
HHSearch
91.46
43%
-116
- C2 -
3UOW
2
?
A:
[7-556]
----
Y
D
K
I
L
V
L
N
F
G
S
Q
Y
F
H
L
I
V
K
R
L
N
N
I
K
I
F
S
E
T
K
D
Y
G
V
E
L
K
D
--
I
KD
M
N
--
I
K
--
G
V
I
L
S
G
G
P
Y
S
V
T
E
A
--
G
S
P
H
L
K
K
E
V
F
E
Y
F
L
E
K
---
K
I
P
I
F
G
I
C
Y
G
M
Q
E
I
A
V
Q
M
N
G
E
V
K
K
S
K
T
S
E
Y
G
C
T
D
V
N
I
L
R
-------------
N
D
NINNITYCRNFSS
A
M
D
L
Y
S
N
Y
K
L
M
N-----
C
C
L
F
E
------------
N
I
-----
K
S
D-------
I
-----
T
T
-
V
W
M
N
H
N
D
E
V
-
T
K
I
P
E
N
F
Y
L
V
S
-
S
S
-
E
N
C
L
I
C
S
I
Y
N
K
E
Y
N
I
Y
G
V
Q
Y
H
P
E
V
Y
E
-
S
L
D
G
E
L
M
F
Y
N
F
-
A
Y
N
-
I
C
K
C
K
K
-
F
D
P
I
R
Y
H
E
L
E
L
K
N
I
E
K
Y
K
H
D
H
Y
V
I
A
A
M
S
G
G
I
D
S
T
V
A
A
A
Y
T
H
K
I
F
K
-
E
-
R
F
F
G
I
F
I
D
N
G
L
L
R
---
K
N
E
----
A
-------
E
N
----
V
Y
T
F
L
K
-
S
T
F
P
D
------
M
------
N
I
T
--
K
--
I
D
A
S
E
N
F
L
S
----------
N
----------
L
Q
G
V
T
D
P
E
Q
K
R
K
I
I
G
K
L
F
I
E
E
F
E
K
---
A
V
N
N
-
I
DID
I
---
N
----
K
T
F
L
L
Q
G
T
L
Y
P
D
I
I
E
S
K
-
C
--
S
---------------------
L
--
K
F
--
K
L
F
E
P
F
K
Y
L
F
K
D
D
V
K
T
L
S
R
E
L
N
L
P
E
E
I
T
N
R
H
P
F
P
G
P
G
L
A
I
R
V
I
G
E
I
N
-------
K
H
K
L
N
I
------------------------
L
R
E
V
D
D
I
F
I
N
D
L
K
Q
Y
G
L
Y
--
N
Q
I
S
Q
A
F
------------------
A
V
L
L
S
S
K
S
V
--------
Y
D
Y
V
C
V
L
---------------------------------------------------------------------------------------------------------
R
A
V
K
T
S
S
F
M
T
A
N
--
W
Y
----
Q
I
P
---------
Y
D
I
L
D
K
I
T
T
R
I
L
S
E
V
K
G
V
N
R
I
L
Y
D
V
S
S
K
P
P
A
T
I
E
F
E
22
PsiBlast_CBE
91.46
45%
-116
- C2 -
1GPM
5
GUAA_ECOLI
C:
[10-525]
-------
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
W
D
V
T
E
A
Q
--
I
--
R
D
--
F
N
PS
G
I
I
L
S
G
G
P
E
S
T
T
E
E
N
S
P
R
A
P
------
Q
Y
V
F
E
A
---
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
R
E
F
G
Y
A
Q
V
E
V
V
N
-------------
D
S
-------------------------
A
L
---
V
R
G
I
E
------------
D
A
-----
L
T
--------
A
DGKPL
L
D
-
V
W
M
S
H
G
D
K
V
-
T
A
I
P
S
D
F
I
T
V
A
-
S
-
T
E
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
-
T
R
Q
G
M
R
M
L
E
R
F
-
V
R
D
-
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
-
N
L
T
C
V
F
V
D
N
G
L
L
R
---
L
N
E
----
A
-------
E
Q
----
V
------
L
D
--
M
FGDHFG
L
------
N
I
V
--
H
--
V
P
A
E
D
R
F
L
S
----------
A
----------
L
A
G
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
---
E
A
L
K
-
L
---
E
---
D
----
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
S
A
A----------------------------
K
M
--
G
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
V
K
-------
K
E
Y
C
D
L
------------------------
L
R
R
A
D
A
I
F
I
E
E
L
R
K
A
D
L
Y
--
D
K
V
S
Q
A
F
------------------
T
V
F
L
P
V
R
S
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
---------------------------------------------------------------------------------------------------------
R
A
V
E
T
I
D
F
M
T
A
---------------
H
W
A
H
L
P
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
50
HHSearch
89.51
45%
-113
- C2 -
2YWB
-
GUAA_THET8
A:
[1-503]
------
M
V
L
V
L
D
F
G
S
Q
Y
T
R
L
I
A
R
R
L
R
E
L
R
A
F
S
L
I
L
P
G
D
A
P
L
E
E
--
V
L
K
H
R
--
P
Q
--
A
L
I
L
S
G
G
P
R
S
V
F
D
P
--
D
A
P
R
P
D
P
----
R
L
F
S
S
---
G
L
P
L
L
G
I
C
Y
G
M
Q
L
L
A
Q
E
L
G
G
R
V
E
R
A
---
E
Y
G
K
A
L
L
T
R
H
--------------
E
G
-------------------------------
P
L
F
R
------------
G
L
-----
E
G
--------
E
-----
V
Q
-
V
W
M
S
H
Q
D
A
V
-
T
A
P
P
P
G
W
R
V
V
A
-
E
T
-
E
E
N
P
V
A
A
I
A
S
P
D
G
R
A
Y
G
V
Q
F
H
P
E
V
A
H
-
T
P
K
G
M
Q
I
L
E
N
F
-
L
-
E
-
L
A
G
V
K
R
D
W
T
P
E
H
V
L
E
E
L
L
R
E
V
R
E
R
A
G
K
D
R
V
L
L
A
V
S
G
G
V
D
S
S
T
L
A
L
L
L
A
K
A
-
G
-
V
-
D
H
L
A
V
F
V
D
H
G
L
L
R
---
L
G
E
----
R
-------
E
E
----
V
E
G
A
L
R
-
A
L
--
G
------
V
------
N
L
L
--
V
--
V
D
A
K
E
R
F
L
K
----------
A
----------
L
K
G
V
E
D
P
E
E
K
R
K
I
I
G
R
E
F
V
A
A
F
S
Q
---
V
A
R
E
-
R
-------
G
P---
F
R
F
L
A
Q
G
T
L
Y
P
D
V
I
E
-----------------------
G
L
P
E
D
L
--
E
F
--
E
L
L
E
P
F
R
L
L
F
K
D
E
V
R
E
L
A
L
L
L
G
L
P
D
T
L
R
L
R
H
P
F
P
G
P
G
L
A
V
R
V
L
G
E
V
T
-------
E
E
R
L
E
I
------------------------
L
R
R
A
D
D
I
F
T
S
L
L
R
E
W
G
L
Y
--
E
K
V
A
Q
A
L
------------------
A
V
L
T
P
V
------------
G
Y
V
L
A
L
---------------------------------------------------------------------------------------------------------
R
A
V
T
T
E
D
F
M
T
A
D
--
W
A
----
R
L
P
---------
L
E
F
L
D
E
A
A
R
R
I
T
R
R
V
P
E
I
G
R
V
V
Y
D
L
T
S
K
P
P
A
T
I
E
W
E
5
PsiBlast_PDB
89.34
39%
-122
- C2 -
3UOW
2
?
A:
[10-556]
-------
I
L
V
L
N
F
G
S
Q
Y
F
H
L
I
V
K
R
L
N
N
I
K
I
F
S
E
T
K
D
Y
G
V
E
L
K
D
--
I
--
K
D
--
M
N
IK
G
V
I
L
S
G
G
P
Y
S
V
T
E
A
G
S
--
P
H
L
K
K
E
V
F
E
Y
F
L
E
K
---
K
I
P
I
F
G
I
C
Y
G
M
Q
E
I
A
V
Q
M
N
G
E
V
K
K
S
K
T
S
E
Y
G
C
T
D
V
N
I
L
R
NDNINNITYCRNF---------------------------
S
S
---
A
M
D
L
Y
S
N
Y
K
L
M
NCCLFE
N
I
-----
K
S
--------
D
-----
I
T
T
V
W
M
N
H
N
D
E
V
-
T
K
I
P
E
N
F
Y
L
V
S
-
S
S
E
-
N
C
L
I
C
S
I
Y
N
K
E
Y
N
I
Y
G
V
Q
Y
H
P
E
V
Y
E
-
S
L
D
G
E
L
M
F
Y
N
F
A
Y
-
N
-
I
C
K
C
K
K
-
F
D
P
I
R
Y
H
E
L
E
L
K
N
I
E
K
Y
K
H
D
H
Y
V
I
A
A
M
S
G
G
I
D
S
T
V
A
A
A
Y
T
H
K
I
F
K
-
E
-
R
F
F
G
I
F
I
D
N
G
L
L
R
---
K
N
E
----
A
E
N
V
Y
T
F
L
K
S
----
T
------
F
P
--
D
------
M
------
N
I
T
--
K
--
I
D
A
S
E
N
F
L
S
----------
N
----------
L
Q
G
V
T
D
P
E
Q
K
R
K
I
I
G
K
L
F
I
E
E
F
E
K
---
A
V
N
N
-
I
---
D
IDI
N
----
K
T
F
L
L
Q
G
T
L
Y
P
D
I
I
E
S
K
-
C
--
S
---------------------
L
--
K
F
--
K
L
F
E
P
F
K
Y
L
F
K
D
D
V
K
T
L
S
R
E
L
N
L
P
E
E
I
T
N
R
H
P
F
P
G
P
G
L
A
I
R
V
I
G
E
I
N
-------
K
H
K
L
N
I
------------------------
L
R
E
V
D
D
I
F
I
N
D
L
K
Q
Y
G
L
Y
--
N
Q
I
S
Q
A
F
------------------
A
V
L
L
S
S
K
S
V
--------
Y
D
Y
V
C
V
L
---------------------------------------------------------------------------------------------------------
R
A
V
K
T
S
S
F
M
T
A
N
--
W
Y
----
Q
---------
I
P
Y
D
I
L
D
K
I
T
T
R
I
L
S
E
V
K
G
V
N
R
I
L
Y
D
V
S
S
K
P
P
A
T
I
E
F
E
24
PsiBlast_CBE
78.81
34%
-116
- C2 -
2VXO
4
GUAA_HUMAN
B:
[31-566]
------
A
V
V
I
L
D
A
G
A
Q
Y
G
K
V
I
D
R
R
V
R
E
L
F
V
Q
S
E
I
F
P
L
E
T
P
A
F
A
--
I
--
K
E
Q
G
F
R
--
A
I
I
I
S
G
G
P
N
S
V
Y
---------
A
E
D
A
P
W
F
D
P
A
I
FTI
G
K
P
V
L
G
I
C
Y
G
M
Q
M
M
N
K
V
F
G
G
T
V
H
K
K
S
---
D
G
V
F
N
I
S
V
D
N
-------------
T
C
-------------------------
S
L
---
F
R
---------------
G
L
-----
Q
K
--------
E
-----
E
V
-
V
L
L
T
H
G
D
S
V
-
D
K
V
A
D
G
F
K
V
V
A
R
S
G
N
I
---
V
A
G
I
A
N
E
S
K
K
L
Y
G
A
Q
F
H
P
E
V
G
L
-
T
E
N
G
K
V
I
L
K
N
F
-
L
Y
D
-
I
A
G
C
S
G
T
F
T
V
Q
N
R
E
L
E
C
I
R
E
I
K
E
R
V
G
T
S
K
V
L
V
L
L
S
G
G
V
D
S
T
V
C
T
A
L
L
N
R
A
L
N
-
Q
E
Q
V
I
A
V
H
I
D
N
G
F
M
R
---
K
R
E
----
S
-------
Q
S
----
V
------
E
E
--
A
L
K
K
L
G-
I
------
Q
V
K
--
V
--
I
N
A
A
H
S
F
Y
N
G
T
T
T
L
PRISK
T
----------
L
N
M
T
T
S
P
E
E
K
R
K
I
I
G
D
T
F
V
K
I
A
N
E
V
I
G
E
M
N
L
-
K
---
P
---
E
----
E
V
F
L
A
Q
G
T
L
R
P
D
L
I
E
S
A
-
S
L
V
A
--
S
G
K
A
E
L
I
K
T
H
H
N
D
T
E
L
I
R
K
L
--
R
E
E
G
K
V
I
E
P
L
K
D
F
H
K
D
E
V
R
I
L
G
R
E
L
G
L
P
E
E
L
V
S
R
H
P
F
P
G
P
G
L
A
I
R
V
I
C
A
E
E
PYICKD
F
P
E
T
N
N
I
------------------------
L
K
I
V
A
D
F
S
A
S
V
K
K
P
H
T
L
L
--
Q
R
V
K
A
C
T
T
E
E
D
Q
E
K
L
M
Q
I
T
S
L
H
S
L
N
A
F
L
L
P
I
K
T
V
G
V
Q
G
D
C
R
S
Y
S
Y
V
C
G
I
---------------------------------------------------------------------------------------------------------
S
S
K
D
E
P
D
-------------------------
W
E
S
L
I
F
L
A
R
L
I
P
R
M
C
H
N
V
N
R
V
V
Y
I
F
G
P
P
V
K
E
P
P
T
D
V
8
PsiBlast_PDB
78.54
34%
-114
- C2 -
2VXO
4
GUAA_HUMAN
A:
[31-566]
------
A
V
V
I
L
D
A
G
--
Y
G
K
V
I
D
R
R
V
R
E
L
F
V
Q
S
E
I
F
P
L
E
T
P
A
F
A
--
I
--
K
E
Q
G
F
R
--
A
I
I
I
S
G
G
P
----------------
A
P
W
F
D
P
A
I
FTI
G
K
P
V
L
G
I
C
Y
G
M
Q
M
M
N
K
V
F
G
G
T
V
H
K
-------
V
F
N
I
S
V
D
N
-------------
T
C
-------------------------
S
L
---
F
R
---------------
G
L
-----
Q
K
--------
E
-----
E
V
-
V
L
L
T
H
G
D
S
V
-
D
K
V
A
D
G
F
K
V
V
A
R
S
G
N
I
---
V
A
G
I
A
N
E
S
K
K
L
Y
G
A
Q
F
H
P
E
V
G
L
-
T
E
N
G
K
V
I
L
K
N
F
-
L
Y
D
-
I
A
G
C
S
G
T
F
T
V
Q
N
R
E
L
E
C
I
R
E
I
K
E
R
V
G
T
S
K
V
L
V
L
L
S
G
G
V
D
S
T
V
C
T
A
L
L
N
R
A
L
N
-
Q
E
Q
V
I
A
V
H
I
D
N
G
F
M
R
---
K
R
E
----
S
-------
Q
S
----
V
------
E
E
--
A
L
K
K
L
G-
I
------
Q
V
K
--
V
--
I
N
A
A
H
S
F
Y
N
G
T
T
T
L
PRISK
T
----------
L
N
M
T
T
S
P
E
E
K
R
K
I
I
G
D
T
F
V
K
I
A
N
E
V
I
G
E
M
N
L
-
K
---
P
---
E
----
E
V
F
L
A
Q
G
T
L
R
P
D
L
I
E
S
A
-
S
L
V
A
--
S
G
K
A
E
L
I
K
T
H
H
N
D
T
E
L
I
R
K
L
--
R
E
E
G
K
V
I
E
P
L
K
D
F
H
K
D
E
V
R
I
L
G
R
E
L
G
L
P
E
E
L
V
S
R
H
P
F
P
G
P
G
L
A
I
R
V
I
C
A
E
E
PYICKD
F
P
E
T
N
N
I
------------------------
L
K
I
V
A
D
F
S
A
S
V
K
K
P
H
T
L
L
--
Q
R
V
K
A
C
T
T
E
E
D
Q
E
K
L
M
Q
I
T
S
L
H
S
L
N
A
F
L
L
P
I
K
T
V
G
V
Q
G
D
C
R
S
Y
S
Y
V
C
G
I
---------------------------------------------------------------------------------------------------------
S
S
K
D
E
P
D
-------------------------
W
E
S
L
I
F
L
A
R
L
I
P
R
M
C
H
N
V
N
R
V
V
Y
I
F
G
P
P
V
K
E
P
P
T
D
V
54
HHSearch
76.44
40%
-96
- C2 -
2VXO
5
GUAA_HUMAN
A:
[30-697]
-----
G
A
V
V
I
L
D
A
G
--
Y
G
K
V
I
D
R
R
V
R
E
L
F
V
Q
S
E
I
F
P
L
E
T
P
A
F
A
I
K
E
--
Q
G
--
F
R
--
A
I
I
I
S
G
G
P
---------
A
P
W
F
D
P
A
-
I
F
---
T
I
---
G
K
P
V
L
G
I
C
Y
G
M
Q
M
M
N
K
V
F
G
G
T
V
H
K
-------
V
F
N
I
S
V
D
N
-------------
T
C
-------------------------------
S
L
F
R
------------
G
L
-----
Q
K
--------
E
-----
E
V
-
V
L
L
T
H
G
D
S
V
-
D
K
V
A
D
G
F
K
V
V
A
-
R
S
-
G
N
-
I
V
A
G
I
A
N
E
S
K
K
L
Y
G
A
Q
F
H
P
E
V
G
L
-
T
E
N
G
K
V
I
L
K
N
F
-
L
Y
D
-
I
A
G
C
S
G
T
F
T
V
Q
N
R
E
L
E
C
I
R
E
I
K
E
R
V
G
T
S
K
V
L
V
L
L
S
G
G
V
D
S
T
V
C
T
A
L
L
N
R
A
L
N
Q
E
-
Q
V
I
A
V
H
I
D
N
G
F
M
R
---
K
R
E
----
S
-------
Q
S
----
V
E
E
A
L
K
-
K
L
--
G
------
I
------
Q
V
K
--
V
--
I
N
A
A
H
S
F
Y
N
----------
G
T
T
T
L
PRISKT
L
N
M
T
T
S
P
E
E
K
R
K
I
I
G
D
T
F
V
K
I
A
N
E
---
V
I
G
E
-
M
-------
N
LKPE
E
V
F
L
A
Q
G
T
L
R
P
D
L
I
E
S
A
-
S
--
L
V
A
S
G
K
A
E
L
I
K
T
H
H
N
D
T
E
L
I
R
K
L
R
E
E
G
--
K
V
I
E
P
L
K
D
F
H
K
D
E
V
R
I
L
G
R
E
L
G
L
P
E
E
L
V
S
R
H
P
F
P
G
P
G
L
A
I
R
V
I
C
A
E
E
-------
P
Y
I
C
K
D
F
P
E
T
N
N
I
L
K
I
V
A
D
F
S
A
S
V
K
K
PH
T
L
L
Q
R
V
K
A
C
T
T
E
E
D
Q
E
-
K
L
M
Q
I
T
S
L
H
S
L
N
------------------
A
F
L
L
P
I
K
T
V
G
V
Q
G
D
C
R
S
Y
S
Y
V
C
G
I
S
S
KDEPD
W
E
S
L
I
F
L
A
R
L
I
P
R
M
C
HNVN
R
V
V
Y
I
F
G
PPVKEPPTDVTPTFLT
T
G
V
L
S
T
L
R
Q
A
D
F
E
A
H
N
I
L
R
E
S
GYAGKIS
Q
M
P
V
I
L
T
PLHFDRDPLQKQPSC
Q
R
S
V
V
I
R
T
F
I
T
S
D
F
M
T
G
I
--
P
A
TPGN
E
I
P
---------
V
E
V
V
L
K
M
V
T
E
I
-
K
K
I
P
G
I
S
R
I
M
Y
D
L
T
S
K
P
P
G
T
T
E
W
E
6
PsiBlast_PDB
69.88
51%
-124
- C2 -
2DPL
-
GUAAB_PYRHO
A:
[2-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
--
R
F
V
E
E
K
V
R
E
I
R
E
T
V
G
D
S
K
A
I
I
A
L
S
G
G
V
D
S
S
T
A
A
V
L
A
H
K
A
I
G
-
D
-
R
L
H
A
V
F
V
N
T
G
F
L
R
---
K
G
E
P
E
F
V
V
-------
K
T
----
F
------
R
D
--
E
------
F
------
G
M
N
L
H
Y
--
V
D
A
Q
D
R
F
F
S
----------
A
----------
L
K
G
V
T
D
P
E
E
K
R
K
I
I
G
R
V
F
I
E
V
F
E
E
---
V
A
K
K
-
I
---
G
--------
A
E
Y
L
I
Q
G
T
I
A
P
--------------------------------
L
--
N
L
--
K
L
I
E
P
L
R
D
L
Y
K
D
E
V
R
E
L
A
K
F
L
G
L
P
E
K
I
Y
N
R
M
P
F
P
G
P
G
L
A
V
R
V
I
G
E
V
T
-------
P
E
K
I
R
I
------------------------
V
R
E
A
N
A
I
V
E
E
E
V
E
R
A
G
L
----
R
P
W
Q
A
F
------------------
A
V
L
L
G
V
K
T
V
G
V
Q
G
D
I
R
A
Y
K
E
T
I
A
V
---------------------------------------------------------------------------------------------------------
R
I
V
E
S
I
D
G
M
T
A
N
--
A
M
----
N
---------
V
P
W
E
V
L
Q
R
I
A
F
R
I
T
S
E
I
P
E
V
G
R
V
L
Y
D
I
T
N
K
P
P
A
T
I
E
F
E
7
PsiBlast_PDB
69.86
51%
-124
- C2 -
3A4I
-
GUAAB_PYRHO
A:
[2-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
--
R
F
V
E
E
K
V
R
E
I
R
E
T
V
G
D
S
K
A
I
I
A
L
S
G
G
V
D
S
S
T
A
A
V
L
A
H
K
A
I
G
-
D
-
R
L
H
A
V
F
V
N
T
G
F
L
R
---
K
G
E
P
E
F
V
V
-------
K
T
----
F
------
R
D
--
E
------
F
------
G
M
N
L
H
Y
--
V
D
A
Q
D
R
F
F
S
----------
A
----------
L
K
G
V
T
D
P
E
E
K
R
K
I
I
G
R
V
F
I
E
V
F
E
E
---
V
A
K
K
-
I
---
G
--------
A
E
Y
L
I
Q
G
T
I
A
P
-----------------------------------
N
L
--
K
L
I
E
P
L
R
D
L
Y
K
D
E
V
R
E
L
A
K
F
L
G
L
P
E
K
I
Y
N
R
M
P
F
P
G
P
G
L
A
V
R
V
I
G
E
V
T
-------
P
E
K
I
R
I
------------------------
V
R
E
A
N
A
I
V
E
E
E
V
E
R
A
G
L
----
R
P
W
Q
A
F
------------------
A
V
L
L
G
V
K
T
V
G
V
Q
G
D
I
R
A
Y
K
E
T
I
A
V
---------------------------------------------------------------------------------------------------------
R
I
V
E
S
I
D
G
M
T
A
N
--
A
M
----
N
---------
V
P
W
E
V
L
Q
R
I
A
F
R
I
T
S
E
I
P
E
V
G
R
V
L
Y
D
I
T
N
K
P
P
A
T
I
E
F
E
55
HHSearch
68.60
54%
-117
- C2 -
2DPL
-
GUAAB_PYRHO
A:
[2-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
R
F
V
E
E
K
V
R
E
I
R
E
T
V
G
D
S
K
A
I
I
A
L
S
G
G
V
D
S
S
T
A
A
V
L
A
H
K
A
I
G
-
D
-
R
L
H
A
V
F
V
N
T
G
F
L
R
---
K
G
E
----
P
-------
E
F
V
V
K
T
F
RD----
E
F
--
G
------
M
------
N
L
H
--
Y
--
V
D
A
Q
D
R
F
F
S
----------
A
----------
L
K
G
V
T
D
P
E
E
K
R
K
I
I
G
R
V
F
I
E
V
F
E
E
---
V
A
K
K
-
I
-------
G
----
A
E
Y
L
I
Q
G
T
I
A
P
--------------------------------
L
--
N
L
--
K
L
I
E
P
L
R
D
L
Y
K
D
E
V
R
E
L
A
K
F
L
G
L
P
E
K
I
Y
N
R
M
P
F
P
G
P
G
L
A
V
R
V
I
G
E
V
T
-------
P
E
K
I
R
I
------------------------
V
R
E
A
N
A
I
V
E
E
E
V
E
R
A
G
L
----
R
P
W
Q
A
F
------------------
A
V
L
L
G
V
K
T
V
G
V
Q
G
D
I
R
A
Y
K
E
T
I
A
V
---------------------------------------------------------------------------------------------------------
R
I
V
E
S
I
D
G
M
T
A
N
--
A
M
----
N
V
P
---------
W
E
V
L
Q
R
I
A
F
R
I
T
S
E
I
P
E
V
G
R
V
L
Y
D
I
T
N
K
P
P
A
T
I
E
F
E
77
Fugue
56.08
50%
-106
- C2 -
1GPM
2
GUAA_ECOLI
A:
[208-404]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
-
N
L
T
C
V
F
V
D
N
G
L
L
R
---
L
N
E
----
A
-------
E
Q
----
V
------
L
D
--
M
F
GDHFG
L
------
N
I
V
--
H
--
V
P
A
E
D
R
F
L
S
----------
A
----------
L
A
G
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
---
E
A
L
K
-
L
---
E
---
D
----
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
S
A
--------------------------
A
--
K
M
--
G
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
V
K
-------
K
E
Y
C
D
L
------------------------
L
R
R
A
D
A
I
F
I
E
E
L
R
K
A
D
L
Y
--
D
K
V
S
Q
A
F
------------------
T
V
F
L
P
V
R
S
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
---------------------------------------------------------------------------------------------------------
R
A
V
E
T
I
D
F
M
T
A
H
--
W
A
----
H
L
P
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
---------
78
Fugue
55.15
37%
-119
- C2 -
1GPM
1
GUAA_ECOLI
A:
[3-207]
ENIH
K
H
R
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
W
D
V
T
E
A
Q
--
I
--
R
D
--
F
N
PS
G
I
I
L
S
G
G
P
E
S
T
T
E
--
E
N
S
P
R
A
P
Q
Y
V
F
-
E
A
------
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
R
E
F
G
Y
A
Q
V
E
V
V
N
-------------
D
S
-------------------------
A
L
---
V
R
G
I
E
------------
D
A
LTADG
K
P
--------
L
-----
L
D
-
V
W
M
S
H
G
D
K
V
T-
A
I
P
S
D
F
I
T
V
A
-
S
T
-
E
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
-H
T
R
Q
G
M
R
M
L
E
R
F
-
V
-
R
D
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
-
N
L
T
C
V
F
V
D
N
G
L
L
R
---
L
N
E
----
A
-------
E
Q
----
V
------
L
D
--
M
------
F
------
G
D
H
--
F
--
G
L
N
I
V
H
V
P
A
----------
E
----------
D
R
F
L
S
A
L
A
G
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
---
V
E
V
F
-
D
---
E
---
E
----
A
L
K
L
E
D
V
K
W
L
A
Q
G
T
I
Y
P
-
D
--
V
--
I
E
S
A
A
K
M
G
L
V
E
P
L
K
E
L
F
K
D
E
--
V
R
--
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
V
K
K
E
Y
C
D
L
L
R
R
A
D
A
I
F
I
-------
E
E
L
R
K
A
------------------------
D
L
Y
D
K
V
S
Q
A
F
T
V
F
L
P
V
R
S
--
V
G
V
M
G
D
G
------------------
R
K
Y
D
W
V
V
S
L
R
A
V
E
T
I
D
F
M
T
A
H
W
A
H
---------------------------------------------------------------------------------------------------------
L
P
Y
D
F
L
G
R
V
S
N
R
--
I
I
----
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
------------------------