@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0480: (2015-12-01 )
MDNTIIRKYDIRGVVGKDLQINDGYEIGRKFGQTVANVCVGYDSRIDSPSIEKELIRGLTLSGANVIRIGLCSSPMLYAATQITQADLGIIITASHNPSDYNGFKFFSSEKVYLDQETKEIISSSIKNSTKIGSLINVNIYSQYIRVLKSAVKNNSTQKLKIAWDCGNSPASGILRYIETILPGHTHIIINNSIDGVFPLHNPDPIEEKNLVQLIDIVKQDKCDLGIALDGDSDRVRLIDNKGSIVSNDHLFMIFVREVLEECPRSKVIANVKMSMKVHDFVSKLGGQVVTCATGHSLVKKKMVEEGAKFAGELSGHFFFSELGFDDGLYSAIKAIDILLKQSQGLSQMIEDLPKLYITHEVKIVVKDEKKFQIIELIKKTLEQQNIAFSDLDGIKVTGNDNKGWWLLRVSNTQNCITARCEGDTLEDFELTKKVLFRYIDKAKSLDCNLS
Atome Classification :
(20 SA)
----.........10........20........30.-...-------.-----.-------..40........50........60........70........80..--------...--------...90........100....-...110.....-.---.120....-------..------.130.......140.......150.--.....-.160-........170...-....180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320--.-......330.......340.-......350.......360.......370.......380.--....-..390.......400.......410.......420.......430.-......440.......450
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MDN
T
I
I
R
K
Y
DIRGVVGKDLQIN
D
G
Y
E
I
G
R
K
F
G
-
Q
T
V
-------
A
-----
N
-------
V
C
VGYDSRIDSP
S
I
E
K
E
L
I
RGLTLSG
A
N
V
I
R
I
GLCSS
P
M
L
Y
A
A
TQI--------TQA--------D
L
G
I
I
I
T
ASHNPSDYN
G
F
K
F
-FSSE
K
V
Y
L
D
Q
E
-
T
---
K
E
I
I
S
S
S
I-------KN------STKIG
S
L
I
N
V
N
I
Y
S
Q
Y
I
R
V
L
K
S
A
V
K--NNST
Q
-
K
L
K
--
I
A
W
DCGNS
P
A
S
G
I
L
-
R
Y
I
E
T
ILPGH
T
H
I
I
I
NNSIDGVFPLHNPDPI
E
E
K
N
L
V
Q
L
I
D
I
V
K
QDKCD
L
G
I
A
LDGDS
D
R
V
R
L
IDNKGSIVSNDH
L
F
M
I
F
V
R
E
V
L
E
ECPRS
K
V
I
A
N
V
K
M
S
M
K
V
H
D
F
V
S
K
LG
G
Q
V
V
T
CAT
G
H
S
L
V
K
K
K
M
V
E
E
G
A
K
F
A
G
E
LSG
H
F
F
F
S
E--L-GFD
D
G
L
Y
S
A
I
K
A
I
D
I
L
L
KQS-Q
G
L
S
Q
M
I
E
D
L
P
K
L
Y
I
T
H
E
V
K
I
V
V
KDEK
K
F
Q
I
I
E
L
I
K
K
T
L
E
--QQNI-AFSDLD
G
I
K
V
TGNDNK
G
W
W
L
L
R
VSNTQ
N
C
I
T
ARCEGDT
L
E
D
F
E
L
T
K
-
K
V
L
F
R
Y
I
D
K
AKSLDCNLS
2
PsiBlast_PDB
97.08
36%
-81
- C2 -
1K2Y
2
ALGC_PSEAE
X:
[9-460]
----
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-------
A
-----
R
GEPC---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
--------
K
S
G
V
M
L
T
G
A
H
N
P
P
D
Y
N
G
F
K
I
-
V
V
A
G
E
T
L
A
N
E
Q
-
I
---
Q
A
L
R
E
R
I
E
-------
K
N
DL----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
----
M
A
K
-
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
--
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
-
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
--
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
--
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
-
T
V
-
F
R
--
N
Q
L
K
A
V
D
S
S
L
P
43
Fugue
96.02
36%
-80
- C2 -
1K2Y
2
ALGC_PSEAE
X:
[5-463]
KAPT
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
-
S
E
S
-------
L
ARGEP
C
-------
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
--------
K
S
G
V
M
L
T
G
A
H
N
P
P
D
Y
N
G
F
K
I
-
V
V
A
G
E
T
L
A
N
E
Q
-
I
---
Q
A
L
R
E
R
I
E
-------
K
N
DL----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
--
M
A
--
K
-
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
-
P
Q
L
I
E
A
L
-
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
-
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
--
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
D
Y
P
K
--
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
-
T
V
F
R
N
Q
L
K
A
V
D
S
S
L
P
V
P
F
11
PsiBlast_PDB
95.64
36%
-82
- C2 -
4IL8
3
ALGC_PSEAE
A:
[9-460]
----
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-------
A
-----
R
GEP
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
--------
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
-
V
V
A
G
E
T
L
A
N
E
Q
-
I
---
Q
A
L
R
E
R
I
E
-------
K
N
D
L
----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
----
M
A
K
-
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
--
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
A
V
F
F
K
E
RW
F
-
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
-
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
--
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
--
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
-
T
V
-
F
R
--
N
Q
L
K
A
V
D
S
S
L
P
14
PsiBlast_PDB
95.49
36%
-84
- C2 -
1K35
1
ALGC_PSEAE
A:
[9-460]
----
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-------
A
-----
R
GEP
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
--------
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
-
V
V
A
G
E
T
L
A
N
E
Q
-
I
---
Q
A
L
R
E
R
I
E
-------
K
N
DL----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
----
M
A
K
-
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
--
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
-
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
--
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
--
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
-
T
V
-
F
R
--
N
Q
L
K
A
V
D
S
S
L
P
12
PsiBlast_PDB
95.47
36%
-81
- C2 -
3BKQ
2
ALGC_PSEAE
X:
[9-460]
----
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-------
A
-----
R
GEPC---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
--------
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
-
V
V
A
G
E
T
L
A
N
E
Q
-
I
---
Q
A
L
R
E
R
I
E
-------
K
N
DL----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
----
M
A
K
-
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
--
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
-
R
D
S
E
H
V
F
S
A
F
G
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
--
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
--
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
-
T
V
-
F
R
--
N
Q
L
K
A
V
D
S
S
L
P
8
PsiBlast_PDB
95.36
36%
-80
- C2 -
1PCM
2
ALGC_PSEAE
X:
[9-460]
----
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-------
A
-----
R
GEPC---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
--------
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
-
V
V
A
G
E
T
L
A
N
E
Q
-
I
---
Q
A
L
R
E
R
I
E
-------
K
N
DL----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
----
M
A
K
-
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
--
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
-
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
--
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
--
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
-
T
V
-
F
R
--
N
Q
L
K
A
V
D
S
S
L
P
1
PsiBlast_PDB
95.30
37%
-80
- C2 -
4MRQ
13
ALGC_PSEAE
A:
[1-452]
----
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-------
A
-----
R
GEP
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
--------
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
-
V
V
A
G
E
T
L
A
N
E
Q
-
I
---
Q
A
L
R
E
R
I
E
-------
K
N
D
L
----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
----
M
A
K
-
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
--
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
-
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
--
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
--
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
-
T
V
-
F
R
--
N
Q
L
K
A
V
D
S
S
L
P
13
PsiBlast_PDB
95.14
36%
-83
- C2 -
3C04
1
ALGC_PSEAE
A:
[9-460]
----
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-------
A
-----
R
GEP
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
--------
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
-
V
V
A
G
E
T
L
A
N
E
Q
-
I
---
Q
A
L
R
E
R
I
E
-------
K
N
DL----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
----
M
A
K
-
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
--
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
-
R
D
S
E
H
V
F
S
A
F
G
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
--
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
--
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
-
T
V
-
F
R
--
N
Q
L
K
A
V
D
S
S
L
P
3
PsiBlast_PDB
95.10
36%
-81
- C2 -
2FKF
2
ALGC_PSEAE
A:
[8-459]
----
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-------
A
-----
R
GEP
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
--------
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
-
V
V
A
G
E
T
L
A
N
E
Q
-
I
---
Q
A
L
R
E
R
I
E
-------
K
N
D
L
----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
----
M
A
K
-
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
--
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
-
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
--
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
--
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
-
T
V
-
F
R
--
N
Q
L
K
A
V
D
S
S
L
P
4
PsiBlast_PDB
94.43
36%
-79
- C2 -
2FKM
2
ALGC_PSEAE
X:
[9-459]
-----
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-------
A
-----
R
GEPC---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
--------
K
S
G
V
M
L
T
G
D
H
N
P
P
D
Y
N
G
F
K
I
-
V
V
A
G
E
T
L
A
N
E
Q
-
I
---
Q
A
L
R
E
R
I
E
-------
K
N
DL----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
----
M
A
K
-
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
--
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
-
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
--
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
--
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
-
T
V
-
F
R
--
N
Q
L
K
A
V
D
S
S
L
P
5
PsiBlast_PDB
94.41
36%
-78
- C2 -
1P5D
2
ALGC_PSEAE
X:
[9-460]
----
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-------
A
-----
R
GEPC---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
--------
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
-
V
V
A
G
E
T
L
A
N
E
Q
-
I
---
Q
A
L
R
E
R
I
E
-------
K
N
DL----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
----
M
A
K
-
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
--
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
-
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
--
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
--
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
-
T
V
-
F
R
--
N
Q
L
K
A
V
D
S
S
L
P
6
PsiBlast_PDB
94.39
36%
-78
- C2 -
1P5G
2
ALGC_PSEAE
X:
[9-460]
----
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-------
A
-----
R
GEPC---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
--------
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
-
V
V
A
G
E
T
L
A
N
E
Q
-
I
---
Q
A
L
R
E
R
I
E
-------
K
N
DL----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
----
M
A
K
-
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
--
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
-
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
--
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
--
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
-
T
V
-
F
R
--
N
Q
L
K
A
V
D
S
S
L
P
23
HHSearch
94.34
38%
-78
- C2 -
1P5D
2
ALGC_PSEAE
X:
[10-457]
-----
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
-
S
E
S
LARGE--
P
-----
C
-------
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
--------
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
-
V
V
A
-
G
E
T
L
A
N
E
Q
I
---
Q
A
L
R
E
R
I
E
-------
K
N
DL----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
----
M
-
A
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
-
P
Q
L
I
E
A
L
G
C
S
-
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
-
Q
D
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
--
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
D
Y
P
--
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
-
T
V
F
R
N
Q
L
K
A
V
D
S
S
L
P
V
P
F
10
PsiBlast_PDB
94.03
36%
-77
- C2 -
2H5A
2
ALGC_PSEAE
X:
[9-460]
----
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-------
A
-----
R
GEPC---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
--------
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
-
V
V
A
G
E
T
L
A
N
E
Q
-
I
---
Q
A
L
R
E
R
I
E
-------
K
N
DL----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
----
M
A
K
-
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
--
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
-
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
--
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
--
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
-
T
V
-
F
R
--
N
Q
L
K
A
V
D
S
S
L
P
9
PsiBlast_PDB
93.87
36%
-78
- C2 -
2H4L
2
ALGC_PSEAE
X:
[9-460]
----
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-------
A
-----
R
GEPC---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
--------
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
-
V
V
A
G
E
T
L
A
N
E
Q
-
I
---
Q
A
L
R
E
R
I
E
-------
K
N
DL----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
----
M
A
K
-
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
--
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
-
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
--
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
--
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
-
T
V
-
F
R
--
N
Q
L
K
A
V
D
S
S
L
P
7
PsiBlast_PDB
93.37
36%
-78
- C2 -
1PCJ
2
ALGC_PSEAE
X:
[9-460]
----
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
-------
A
-----
R
GEPC---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
--------
L
E
G
--------
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
-
V
V
A
G
E
T
L
A
N
E
Q
-
I
---
Q
A
L
R
E
R
I
E
-------
K
N
DL----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
----
M
A
K
-
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
--
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
RW
F
-
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
-
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
--
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
--
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
-
T
V
-
F
R
--
N
Q
L
K
A
V
D
S
S
L
P
22
HHSearch
90.46
29%
-83
* C2 *
1WQA
1
?
A:
[2-454]
------
G
K
L
F
G
T
F
G
V
R
G
I
A
N
E
K
I
T
P
E
F
A
M
K
I
G
M
A
F
G
-
T
L
L
K
R
E
GRK
K
P
-----
L
-------
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
--------
F
N
A
--------
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
-
L
E
P
N
G
M
G
L
K
K
E
R
E
---
A
I
V
E
E
L
F
F
-------
K
E
DFDRAK
W
Y
E
I
G
E
V
R
R
E
D
I
I
K
P
Y
I
E
A
I
K
S
K
V
D
V
E
A
I
K
-
K
R
K
P
F
--
V
V
V
D
T
S
N
G
A
G
S
L
T
L
-
P
Y
L
L
R
E
L
G
C
K
-
V
I
T
V
N
A
Q
P
D
G
Y
F
P
A
R
N
P
E
P
N
-
E
E
N
L
K
E
F
M
E
I
V
K
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
K
E
K
G
G
G
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
H-
V
-
L
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
-
K
S
G
K
K
F
S
E
L
I
D
E
L
P
K
Y
Y
Q
-
I
K
T
K
R
H
V
E
G
-
D
R
H
A
I
V
N
K
V
A
E
M
A
R
--
E
R
G
Y
-
T
V
D
T
T
D
G
A
K
I
I
F
E
--
D
G
W
V
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
-
N
L
G
I
E
L
L
E
K
A
L
S
------
25
HHSearch
88.02
32%
-81
- C2 -
3UW2
10
?
A:
[23-479]
----
I
S
Q
S
I
F
K
A
Y
D
I
R
G
V
I
G
K
T
L
D
A
D
V
A
R
S
I
G
R
A
F
G
-
S
E
V
R
A
Q
GG--
D
-----
A
-------
V
V
V
A
R
D
G
R
L
S
G
P
E
L
V
G
A
L
A
D
G
L
R
A
A
G
V
D
V
V
D
V
G
M
V
P
T
P
V
G
Y
F
A
A
S
V
PLALSG
G
E
R
R
V
--------
D
S
C
I
V
V
T
G
S
H
N
P
P
D
Y
N
G
F
K
M
-
V
L
R
-
G
A
A
I
Y
G
D
Q
I
---
Q
G
L
Y
K
R
I
V
-------
D
A
R
F
----
E
T
G
S
G
S
Y
E
Q
Y
D
V
A
D
Q
Y
V
E
R
I
V
G
D
I
K
--
L
---
T
R
P
L
K
--
L
V
V
D
A
G
N
G
V
A
G
P
L
A
-
T
R
L
F
K
A
L
G
C
E
-
L
V
E
L
F
T
D
I
D
G
N
F
P
N
H
H
P
D
P
A
H
P
E
N
L
Q
D
V
I
A
K
L
K
A
T
D
A
E
I
G
F
A
F
D
G
D
G
D
R
L
G
V
V
T
K
D
G
Q
I
I
Y
P
D
R
Q
L
M
L
F
A
E
E
V
L
S
R
N
P
G
A
Q
I
I
Y
D
V
K
C
T
R
N
L
A
R
W
V
R
E
K
G
G
E
P
L
M
W
K
T
G
H
S
L
V
K
A
K
L
R
E
T
G
A
P
L
A
G
E
M
S
G
H
V
F
F
K
D
R-
W
Y
G
F
D
D
G
L
Y
T
G
A
R
L
L
E
I
L
A
-
R
V
-
A
D
P
S
A
L
L
N
G
L
P
N
A
V
S
T
P
E
L
Q
L
------
N
V
K
L
I
D
K
L
R
A
D
A
K
FD
G
A
-
D
-
E
V
V
T
I
D
G
L
R
V
E
Y
P
--
D
G
F
G
L
A
R
S
S
N
T
T
P
V
V
V
L
R
F
E
A
T
S
D
A
A
L
A
R
I
Q
-
D
D
F
R
R
A
L
K
A
A
K
P
G
A
N
L
P
F
15
PsiBlast_PDB
87.03
32%
-75
- C2 -
3UW2
10
?
A:
[23-484]
----
I
S
Q
S
I
F
K
A
Y
D
I
R
G
V
I
G
K
T
L
D
A
D
V
A
R
S
I
G
R
A
F
G
-
S
E
V
-------
R
-----
A
Q
GGD
A
--
V
V
V
A
R
D
G
R
L
S
G
P
E
L
V
G
A
L
A
D
G
L
R
A
A
G
V
D
V
V
D
V
G
M
V
P
T
P
V
G
Y
F
A
A
S
V
--------
P
L
A
LSG
G
E
R
R
V
D
S
C
I
V
V
T
G
S
H
N
P
P
D
Y
N
G
F
K
M
V
L
R
G
A
A
I
Y
G
D
Q
I
-
Q
G
L
Y
K
R
I
V
D
A
R
F
-------
E
T
------
G
S
--
G
S
Y
E
Q
Y
D
V
A
D
Q
Y
V
E
R
I
V
G
D
I
K
----
L
T
R
-
P
L
K
--
L
V
V
D
A
G
N
G
V
A
G
P
L
A
-
T
R
L
F
K
A
L
-
G
C
E
L
V
E
L
F
T
D
I
D
G
N
F
P
N
H
H
P
D
P
A
H
P
E
N
L
Q
D
V
I
A
K
L
K
A
T
D
A
E
I
G
F
A
F
D
G
D
G
D
R
L
G
V
V
T
K
D
G
Q
I
I
Y
P
D
R
Q
L
M
L
F
A
E
E
V
L
S
R
N
P
G
A
Q
I
I
Y
D
V
K
C
T
R
N
L
A
R
W
V
R
E
K
G
G
E
P
L
M
W
K
T
G
H
S
L
V
K
A
K
L
R
E
T
G
A
P
L
A
G
E
M
S
G
H
V
F
F
K
D
RW
Y
-
G
F
D
D
G
L
Y
T
G
A
R
L
L
E
I
L
A
R
V
A
-
D
-
P
S
A
L
L
N
G
L
P
N
A
V
S
T
P
E
L
Q
L
------
N
V
K
L
I
D
K
L
R
A
D
A
K
--
F
D
G
A
D
E
V
V
T
I
D
G
L
R
V
E
Y
P
D
--
G
F
G
L
A
R
S
S
N
T
T
P
V
V
V
L
R
F
E
A
T
S
--
D
A
A
L
A
R
I
Q
D
D
F
R
R
A
L
K
A
A
K
P
G
A
N
L
P
16
PsiBlast_PDB
85.13
29%
-77
- C2 -
1WQA
1
?
A:
[8-437]
------------
F
G
V
R
G
I
A
N
E
K
I
T
P
E
F
A
M
K
I
G
M
A
F
G
-
T
L
L
-------
K
-----
R
E
GRK
K
P
L
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
--------
F
N
A
--------
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
-
L
E
P
N
G
M
G
L
K
K
E
-
R
---
E
A
I
V
E
E
L
F
F
K
EDFDR
A
K
------
W
Y
E
I
G
E
V
R
R
E
D
I
I
K
P
Y
I
E
A
I
K
S
K
V
D
--
V
E
A
I
K
-
K
R
K
P
F
V
V
V
D
T
S
N
G
A
G
S
L
T
L
-
P
Y
L
L
R
E
L
-
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
F
P
A
R
N
P
E
P
N
E
E
-
N
L
K
E
F
M
E
I
V
K
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
K
E
K
G
G
G
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
HV
L
-
G
-
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
-
K
K
F
S
E
L
I
D
E
L
P
K
Y
Y
Q
I
K
T
K
R
H
V
E
G
D
--
R
H
A
I
V
N
K
V
A
E
M
A
R
--
E
R
G
Y
-
T
V
D
T
T
D
G
A
K
I
I
F
E
D
--
G
W
V
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
-
N
L
G
I
E
L
L
E
K
A
L
S
------