@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0586: (2015-12-02 )
MLKIAIVGLPNAGKSTLFNRILGRKAAVVSNIPGITRDRQEGVGRISDLELKIIDTGGWNDQTNFFLQIVEQIEFSLFSADIIFFLVDAKVQNEQNKEFAKWLKRRTNKSVILIANKCESYKSENIDYLQFFDFIGPVYISAEHNLGMVDLYNALAGVIDSSTNFSSVIPKPLPVIKVAGTGIQEKNEQISTLHAENQSNQPNRLRVAIIGRPNVGKSTFLNSLLSENRLITSSEPGTTRDSVDITYNHNGKLITLIDTAGIRRRANLIDNLELKFVKKSMESIKRSHVVVLMLDSLLGIKQQDLSIGEAAIKGGKGIIIVLNKWDLINKDDRSRLIKFVRQQEITRLFLEVPTVTISALKGIRCSDVIDKCLEVNEFLNKKISTAKVNKWLVDALGRHPHPFVKGRAIRMKYIAQIGTKPPAFSLTCNVPEGVDESYKRYLTNDLRKNFFIDGIPVRLLLKKNKNPYVK
Atome Classification :
(20 SA)
.........10........20........30........40.....-...50.......-.60....---.....70......-..-.80........90-.-.......100-.......110.......120-..-..-.---....130-------....---...140.......150........160.......170.......180.......190.......200.......210.......220.......230.......240......-.-250.......260--.......270......-.280.......290.......300....-...-310...-.....320.......330.--.......340.--..-....350------........360.....-..370........380.......390---......----.---..400.......410.......420.......430.--------......440........-.450........460.......470
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
K
I
A
I
V
GLPNA
G
K
S
T
L
F
N
R
I
LG
R
K
A
A
V
V
SNIPGIT
R
D
R
Q
EGVGRI-S
D
L
E
L
K
I
I
DTGG-WN-D
Q
T
N
---
F
F
L
Q
I
V
-
E
Q
I
E
F
S
-LF-S
A
D
I
I
F
F
L
VD
A
K
V-Q-NEQ
N
K
E
F
A
K
W
-
L
K
RRTNK
S
V
I
L
I
AN
K
C
ES---YK-SE-N---I
D
Y
L
Q
F
F
-------DFIG---
P
V
Y
I
S
AEHNL
G
M
V
D
-
L
Y
N
A
L
A
G
VIDSSTN
F
S
SVIPKPL
P
V
I
K
VAGTGIQEKNEQ
I
S
T
L
HAENQSNQP
N
R
L
R
V
A
I
I
GRPNV
G
K
S
T
F
L
N
S
L
L
SEN
R
L
ITSSEPGTTRD
S
V
D
I
T
YN-H-NG
K
L
I
T
L
IDTAG
I
--
R
R
R
A
N
L
I
D
N
L
E
L
K
F
V
K
-
K
S
M
E
S
I
K
RS
H
V
V
V
L
M
L
D
S
L
LGI
K
Q
QDLS-I
G
E
-
A
A-IKG-G
K
G
I
I
I
V
L
NKWDLI
N
K
-
D
D
--
R
S
R
L
I
K
F
V
R
Q
Q
--
E
I
-
T
R
L
F
L
E-------VP
T
V
T
I
S
A
LKGI
R
C
S
D
-
V
I
D
-
K
C
L
E
V
N
E
F
L
N
KKI
S
T
A
K
V
N
K
-----
W
L
V
D
A
L----G---RHPHPFVKGR
A
I
R
M
K
Y
I
A
Q
IGTKPP
A
F
S
L
TCNVPEG--------
V
D
E
S
Y
K
R
--
Y
L
T
N
D
L
R
K
-NFF-IDGI
P
V
R
L
L
L
KKNKNPYVK
1
PsiBlast_PDB
91.42
33%
-109
- C5 -
4DCS
2
DER_BACSU
A:
[26-455]
---
V
A
I
V
G
R
P
N
V
G
K
S
T
I
F
N
R
I
A
G
E
R
I
S
-----------
R
I
Y
S
S
A
E
W
-
L
N
Y
D
F
N
L
I
D
T
G
G
-------
P
---
F
L
A
Q
I
R
-
Q
Q
A
E
I
A
-
M
D
-
E
A
D
V
I
I
F
M
V
N
G
R
E
-
G
V
T
A
A
D
E
E
V
A
K
I
-
L
-
Y
R
T
K
K
P
V
V
L
A
V
N
K
L
-------M
R
A
-
N
---
I
Y
D
F
Y
S
L
-------
G
F
G
E
---
P
Y
P
I
S
G
T
H
G
L
G
L
G
D
-
L
L
D
A
V
A
------
E
H
F
-----
K
N
I
P
E
T
K
Y
--------
N
E
E
V
--------------
I
Q
F
C
L
I
G
R
P
N
V
G
K
S
S
L
V
N
A
M
L
G
E
E
R
V
I
V
S
N
------
D
A
V
D
T
S
F
T
-
Y
-
N
Q
Q
E
F
V
I
V
D
T
A
G
M
--
R
K
K
G
K
V
Y
E
T
T
E
K
Y
S
V
L
-
R
A
L
K
A
I
D
R
S
E
V
V
A
V
V
L
D
G
E
E
G
I
I
E
Q
D
K
R
-
I
A
G
-
Y
A
-
H
E
A
-
G
K
A
V
V
I
V
V
N
K
W
D
A
V
D
K
-
D
E
---
S
T
M
K
E
F
E
E
N
I
--
R
D
-
H
F
Q
F
L
D
Y------
A
P
I
L
F
M
S
A
L
T
K
K
R
I
H
T
-
L
M
P
-
A
I
I
K
A
S
E
N
H
S
L
R
V
Q
T
N
V
L
N
D
-----
V
I
M
D
A
V
----
A
---
M
N
P
T
P
T
H
N
G
S
R
L
K
I
Y
Y
A
T
Q
V
S
V
K
P
P
S
F
V
V
F
V
N
D
P
E
L
--------
M
H
F
S
Y
E
R
--
F
L
E
N
R
I
R
D
-
A
F
G
-
F
E
G
T
P
I
K
I
F
A
R
A
R
------
3
PsiBlast_PDB
91.39
33%
-112
- C5 -
4DCV
1
DER_BACSU
A:
[26-456]
---
V
A
I
V
G
R
P
N
V
G
K
S
T
I
F
N
R
I
A
G
E
R
I
S
-----------
R
I
Y
S
S
A
E
W
-
L
N
Y
D
F
N
L
I
D
T
G
G
-------
P
---
F
L
A
Q
I
R
-
Q
Q
A
E
I
A
-
M
D
-
E
A
D
V
I
I
F
M
V
N
G
R
E
-
G
V
T
A
A
D
E
E
V
A
K
I
-
L
-
Y
R
T
K
K
P
V
V
L
A
V
N
K
L
----------------
Y
D
F
Y
S
L
-------
G
F
G
E
---
P
Y
P
I
S
G
T
H
G
L
G
L
G
D
-
L
L
D
A
V
A
------
E
H
F
-----
K
N
I
P
E
T
K
Y
--------
N
E
E
V
--------------
I
Q
F
C
L
I
G
R
P
N
V
G
K
S
S
L
V
N
A
M
L
G
E
E
R
V
I
V
S
N
------
D
A
V
D
T
S
F
T
-
Y
-
N
Q
Q
E
F
V
I
V
D
T
A
G
M
--
R
K
K
G
K
V
Y
E
T
T
E
K
Y
S
V
L
-
R
A
L
K
A
I
D
R
S
E
V
V
A
V
V
L
D
G
E
E
G
I
I
E
Q
D
K
R
-
I
A
G
-
Y
A
-
H
E
A
-
G
K
A
V
V
I
V
V
N
K
W
D
A
V
D
K
-
D
E
---
S
T
M
K
E
F
E
E
N
I
--
R
D
-
H
F
Q
F
L
D
Y------
A
P
I
L
F
M
S
A
L
T
K
K
R
I
H
T
-
L
M
P
-
A
I
I
K
A
S
E
N
H
S
L
R
V
Q
T
N
V
L
N
D
-----
V
I
M
D
A
V
----
A
---
M
N
P
T
P
T
H
N
G
S
R
L
K
I
Y
Y
A
T
Q
V
S
V
K
P
P
S
F
V
V
F
V
N
D
P
E
L
--------
M
H
F
S
Y
E
R
--
F
L
E
N
R
I
R
D
-
A
F
G
-
F
E
G
T
P
I
K
I
F
A
R
A
R
K
-----
2
PsiBlast_PDB
90.89
33%
-111
- C5 -
4DCU
2
DER_BACSU
A:
[26-454]
---
V
A
I
V
G
R
P
N
V
G
K
S
T
I
F
N
R
I
A
G
E
R
I
S
-----------
R
I
Y
S
S
A
E
W
-
L
N
Y
D
F
N
L
I
D
T
G
G
-------
P
---
F
L
A
Q
I
R
-
Q
Q
A
E
I
A
-
M
D
-
E
A
D
V
I
I
F
M
V
N
G
R
E
-
G
V
T
A
A
D
E
E
V
A
K
I
-
L
-
Y
R
T
K
K
P
V
V
L
A
V
N
K
L
----------------
Y
D
F
Y
S
L
-------
G
F
G
E
---
P
Y
P
I
S
G
T
H
G
L
G
L
G
D
-
L
L
D
A
V
A
------
E
H
F
-----
K
N
I
P
E
T
K
Y
--------
N
E
E
V
--------------
I
Q
F
C
L
I
G
R
P
N
V
G
K
S
S
L
V
N
A
M
L
G
E
E
R
V
I
V
S
N
------
D
A
V
D
T
S
F
T
-
Y
-
N
Q
Q
E
F
V
I
V
D
T
A
G
M
--
R
K
K
G
K
V
Y
E
T
T
E
K
Y
S
V
L
-
R
A
L
K
A
I
D
R
S
E
V
V
A
V
V
L
D
G
E
E
G
I
I
E
Q
D
K
R
-
I
A
G
-
Y
A
-
H
E
A
-
G
K
A
V
V
I
V
V
N
K
W
D
A
V
D
K
-
D
E
---
S
T
M
K
E
F
E
E
N
I
--
R
D
-
H
F
Q
F
L
D
Y------
A
P
I
L
F
M
S
A
L
T
K
K
R
I
H
T
-
L
M
P
-
A
I
I
K
A
S
E
N
H
S
L
R
V
Q
T
N
V
L
N
D
-----
V
I
M
D
A
V
----
A
---
M
N
P
T
P
T
H
N
G
S
R
L
K
I
Y
Y
A
T
Q
V
S
V
K
P
P
S
F
V
V
F
V
N
D
P
E
L
--------
M
H
F
S
Y
E
R
--
F
L
E
N
R
I
R
D
-
A
F
G
-
F
E
G
T
P
I
K
I
F
A
R
A
-------
4
PsiBlast_PDB
89.79
33%
-109
- C5 -
2HJG
3
DER_BACSU
A:
[6-436]
---
V
A
I
V
G
R
P
N
V
G
K
S
T
I
F
N
R
I
A
G
E
R
I
S
-----------
R
I
Y
S
S
A
E
W
-
L
N
Y
D
F
N
L
I
D
----------
P
---
F
L
A
Q
I
R
-
Q
Q
A
E
I
A
-
M
D
-
E
A
D
V
I
I
F
M
V
N
G
R
E
-
G
V
T
A
A
D
E
E
V
A
K
I
-
L
-
Y
R
T
K
K
P
V
V
L
A
V
N
K
L
D
N
---------
N
---
I
Y
D
F
Y
S
L
-------
G
F
G
E
---
P
Y
P
I
S
G
T
H
G
L
G
L
G
D
-
L
L
D
A
V
A
------
E
H
F
-----
K
N
I
P
E
T
K
Y
--------
N
E
E
V
--------------
I
Q
F
C
L
I
G
R
P
N
V
G
K
S
S
L
V
N
A
M
L
G
E
E
R
V
I
V
S
---------
V
D
T
S
F
T
-
Y
-
N
Q
Q
E
F
V
I
V
D
T
A
G
M
--
R
K
K
G
K
V
Y
E
T
T
E
K
Y
S
V
L
-
R
A
L
K
A
I
D
R
S
E
V
V
A
V
V
L
D
G
E
E
G
I
I
E
Q
D
K
R
-
I
A
G
-
Y
A
-
H
E
A
-
G
K
A
V
V
I
V
V
N
K
W
D
A
V
D
K
-
D
E
---
S
T
M
K
E
F
E
E
N
I
--
R
D
-
H
F
Q
F
L
D
Y------
A
P
I
L
F
M
S
A
L
T
K
K
R
I
H
T
-
L
M
P
-
A
I
I
K
A
S
E
N
H
S
L
R
V
Q
T
N
V
L
N
D
-----
V
I
M
D
A
V
----
A
---
M
N
P
T
P
T
H
N
G
S
R
L
K
I
Y
Y
A
T
Q
V
S
V
K
P
P
S
F
V
V
F
V
N
D
P
E
L
--------
M
H
F
S
Y
E
R
--
F
L
E
N
R
I
R
D
-
A
F
G
-
F
E
G
T
P
I
K
I
F
A
R
A
R
K
-----
5
PsiBlast_PDB
86.19
29%
-99
- C5 -
1MKY
6
DER_THEMA
A:
[4-439]
---
V
L
I
V
G
R
P
N
V
G
K
S
T
L
F
N
K
L
V
K
--------------
D
P
V
Q
D
T
V
E
W
-
Y
G
K
T
F
K
L
V
D
T
C
G
V
F
D
-
N
P
Q
D
---
I
I
S
Q
K
M
-
K
E
V
T
L
N
-
M
I
R
E
A
D
L
V
L
F
V
V
D
G
K
R
-
G
I
T
K
E
D
E
S
L
A
D
F
-
L
-
R
K
S
T
V
D
T
I
L
V
A
N
K
A
E
N
L
R
E
F
E
-
R
E
-
V
---
K
P
E
L
Y
S
L
-------
G
F
G
E
---
P
I
P
V
S
A
E
H
N
I
N
L
--------------
D
T
M
L
E
T
I
I
K
K
-----------
L
E
E
K
G
-----
L
D
L
E
S
K
P
E
I
T
D
A
I
K
V
A
I
V
G
R
P
N
V
G
K
S
T
L
F
N
A
I
L
N
K
E
R
A
L
V
S
P
I
P
------
V
D
D
E
V
F
-
I
-
D
G
R
K
Y
V
F
V
D
T
A
G
L
-------------
E
K
Y
S
N
Y
R
V
V
D
S
I
E
K
A
D
V
V
V
I
V
L
D
A
T
Q
G
I
T
R
Q
D
Q
R
-
M
A
G
-
L
M
-
E
R
R
-
G
R
A
S
V
V
V
F
N
K
W
D
L
V
V
H
-
R
E
--
K
-------
R
Y
D
--
E
F
-
T
K
L
F
R
E
K
L
YFIDY
S
P
L
I
F
T
S
A
D
K
G
W
N
I
D
R
-
M
I
D
-
A
M
N
L
A
Y
A
S
Y
T
T
K
V
P
S
S
A
I
N
S
-----
A
L
Q
K
V
L
----
A
---
F
T
N
L
P
----
R
G
L
K
I
F
F
G
V
Q
V
D
I
K
P
P
T
F
L
F
F
V
N
S
I
E
K
--------
V
K
N
P
Q
K
I
--
F
L
R
K
L
I
R
D
-
Y
V
F
P
F
E
G
S
P
I
F
L
K
F
K
R
S
R
-----
95
HHSearch
81.64
30%
-94
- C5 -
1MKY
6
DER_THEMA
A:
[2-439]
-
A
T
V
L
I
V
G
R
P
N
V
G
K
S
T
L
F
N
K
L
V
K
--------------
D
P
V
Q
D
T
V
E
W
-
Y
G
K
T
F
K
L
V
D
T
C
G
-
V
F
-
D
N
P
Q
DI-
I
S
Q
K
M
K
-
E
V
T
L
N
M
-
I
R
-
E
A
D
L
V
L
F
V
V
D
G
K
R
-
G
I
T
K
E
D
E
S
L
A
D
F
-
L
R
K
-
S
T
V
D
T
I
L
V
A
N
K
A
E
N
---
L
R
-
E
F
-
E
R
--
E
V
K
P
E
L
Y
S
L-----
G
F
G
E
---
P
I
P
V
S
A
E
H
N
I
N
L
D
T
-
M
L
E
T
I
I
K
K
L
E
E
K
G
L
D
L
-----------------------------
E
S
K
P
E
I
T
D
A
I
K
V
A
I
V
G
R
P
N
V
G
K
S
T
L
F
N
A
I
L
N
K
E
R
A
L
V
S
P
I
P
------
V
D
D
E
V
F
-
I
-
D
G
R
K
Y
V
F
V
D
T
A
G
L
------------
E
K
Y
S
N
Y
-
R
V
V
D
S
I
E
K
A
D
V
V
V
I
V
L
D
A
T
Q
G
I
T
R
Q
D
Q
R
-
M
A
G
-
L
M
-
E
R
R
-
G
R
A
S
V
V
V
F
N
K
W
D
L
V
V
H
-
R
E
KR
Y
D
E
F
T
K
L
F
R
E
K
-----
L
Y
F
I
D
Y
-------
S
P
L
I
F
T
S
A
D
K
G
W
N
I
D
R
-
M
I
D
-
A
M
N
L
A
Y
A
S
Y
T
T
K
V
P
S
S
A
I
N
S
-----
A
L
Q
K
V
L
----
A
---
F
T
N
L
P
R
----
G
L
K
I
F
F
G
V
Q
V
D
I
K
P
P
T
F
L
F
F
V
N
S
I
E
K
--------
V
K
N
P
Q
K
I
--
F
L
R
K
L
I
R
D
Y
V
F
P
-
F
E
G
S
P
I
F
L
K
F
K
R
S
R
-----
84
Fugue
77.12
28%
-77
- C5 -
1MKY
6
DER_THEMA
A:
[2-439]
-
A
T
V
L
I
V
G
R
P
N
V
G
K
S
T
L
F
N
K
L
V
K
D
P
V
Q
D
T
V
E
W
Y
G
---------------
K
T
F
K
L
V
D
T
C
G
-
V
F
-
D
N
P
Q
---
D
I
I
S
Q
K
M
K
E
V
T
L
N
M
I
R
-
E
A
D
L
V
L
F
V
V
D
G
K
R
G
I
-
T
K
E
D
E
S
L
A
D
F
-
L
R
K
S
-
T
V
D
T
I
L
V
A
N
K
A
E
N
---
L
R
-
E
F
-
E
---
R
E
V
K
P
E
L
-------
Y
S
L
G
F
G
E
P
I
P
V
S
A
E
H
N
I
N
L
D
T
M
L
E
T
I
I
K
K
L
E
E
K
G
L
D
------------------------------
L
E
S
K
P
E
I
T
D
A
I
K
V
A
I
V
G
R
P
N
V
G
K
S
T
L
F
N
A
I
L
N
K
E
R
A
L
V
S
P
I
P
V
D
D
E
V
F
I
--------
D
G
R
K
Y
V
F
V
D
T
A
G
L
--
E
K
Y
S
N
----------
Y
-
R
V
V
D
S
I
E
K
A
D
V
V
V
I
V
L
D
A
T
Q
G
I
T
R
Q
D
Q
R
M
A
G
L
M
E
---
R
R
-
G
R
A
S
V
V
V
F
N
K
W
D
L
V
V
H
-
R
E
--
K
R
Y
D
E
F
T
K
L
F
R
--
E
K
-
L
Y
F
I
D
Y
-------
S
P
L
I
F
T
S
A
D
K
G
W
N
I
D
R
M
I
D
A
M
N
--
L
A
Y
A
S
Y
T
T
K
V
P
S
S
A
I
N
S
-----
A
L
Q
K
V
L
----
A
---
F
T
N
L
P
----
R
G
L
K
I
F
F
G
V
Q
V
D
I
K
P
P
T
F
L
F
F
V
N
S
I
E
K
--------
V
K
N
P
Q
K
I
--
F
L
R
K
L
I
R
D
-
Y
V
F
P
F
E
G
S
P
I
F
L
K
F
K
R
S
R
-----
22
PsiBlast_CBE
60.61
39%
-115
- C5 -
4KYU
5
DER_BACSU
B:
[6-160]
---
V
A
I
V
G
R
P
N
V
G
K
S
T
I
F
N
R
I
A
-----------------
I
Y
S
S
A
E
W
--
N
Y
D
F
N
L
I
D
T
G
G
-
I
D
I
G
D
E
P
---
F
L
A
Q
I
R
-
Q
Q
A
E
I
A
-
M
D
-
E
A
D
V
I
I
F
M
V
N
G
R
E
-
G
V
T
A
A
D
E
E
V
A
K
I
-
L
-
Y
R
T
K
K
P
V
V
L
A
V
N
K
L
D
N
---
T
E
M
R
A
-
N
---
I
Y
D
F
Y
S
L
-------
G
F
G
E
---
P
Y
P
I
S
G
T
H
G
L
G
L
G
D
-
L
L
D
A
V
A
E
H
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
58.50
39%
-106
- C5 -
4KYU
5
DER_BACSU
A:
[6-160]
---
V
A
I
V
G
R
P
N
V
G
K
S
T
I
F
N
R
I
A
G
E
R
I
----------
R
D
R
I
Y
S
S
A
E
W
-
L
N
Y
D
F
N
L
I
D
T
G
G
-
I
D
I
G
D
E
P
---
F
L
A
Q
I
R
-
Q
Q
A
E
I
A
-
M
D
-
E
A
D
V
I
I
F
M
V
N
G
R
E
-
G
V
T
A
A
D
E
E
V
A
K
I
-
L
-
Y
R
T
K
K
P
V
V
L
A
V
N
K
L
D
N
---
T
E
M
R
A
-
N
---
I
Y
D
F
Y
S
L
-------
G
F
G
E
---
P
Y
P
I
S
G
T
H
G
L
G
L
G
D
-
L
L
D
A
V
A
E
H
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
57.59
33%
-118
* C7 *
3R9W
6
ERA_AQUAE
A:
[12-177]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
K
V
S
I
I
S
P
K
A
G
T
T
R
M
R
V
L
G
V
K
N
I
P
-
N
E
A
Q
I
I
F
L
D
T
P
G
I
Y
E
P
K
K
S
D
V
L
G
H
S
M
V
E
I
A
K
-
Q
S
L
E
E
---
A
D
V
I
L
F
M
I
D
A
T
E
G
W
R
P
R
D
E
E
-
I
Y
Q
-
N
F
-
I
K
P
L
N
K
P
V
I
V
V
I
N
K
I
D
K
I
G
P
A
K
N
--
V
L
P
L
I
D
E
I
H
K
K
HP
E
L
-
T
E
I
-------------
V
P
I
S
A
L
K
G
A
N
L
D
E
-
L
V
K
-
T
I
L
K
Y
L
P
E
G
E
P
L
F
P
E
D
M
I
T
D
-----
L
P
L
R
L
L
----
A
---
A
E
I
V
R
E
K
A
M
M
L
T
R
E
E
V
P
T
S
I
A
V
K
I
N
E
I
K
P
G
D
A
N
P
N
M
--------
L
V
I
K
G
E
I
--
I
V
D
R
E
N
L
K
-
P
I
I
-
I
G
K
K
G
Q
R
L
K
E
I
G
K
R
A
R
Q
E
L
104
HHSearch
57.38
28%
-126
- C5 -
1MKY
3
DER_THEMA
A:
[181-356]
-
I
K
V
A
I
V
G
R
P
N
V
G
K
S
T
L
F
N
A
I
L
N
K
E
R
A
L
V
S
P
I
P
------
V
D
D
E
V
F
I
-
D
G
R
K
Y
V
F
V
D
T
A
G
-
L
----------
E
K
Y
S
N
-
Y
R
V
V
D
S
-
I
E
-
K
A
D
V
V
V
I
V
L
D
A
T
Q
-
G
I
T
R
Q
D
Q
R
M
A
G
L
-
M
E
R
-
R
G
R
A
S
V
V
V
F
N
K
W
D
L
---
V
V
-
H
R
-
E
KR
Y
D
E
F
T
K
L
F
R
E
K
L
YFI
D
Y
S
P
---
L
I
F
T
S
A
D
K
G
W
N
I
D
R
-
M
I
D
A
M
N
L
A
Y
A
S
Y
T
T
K
V
P
S
S
A
I
N
S
A
L
Q
K
V
L
A
F
T
N
L
P
R
G
L
K
I
F
F
G
V
Q
V
D
I
K
P
P
T
F
L
F
F
V
N
S
I
E
K
V
K
N
P
Q
K
I
F
L
R
K
L
I
R
D
Y
V
F
P
F
E
G
S
P
I
F
L
K
F
K
R
S
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
56.70
33%
-115
- C7 -
3IEV
2
ERA_AQUAE
A:
[13-178]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
K
V
S
I
I
S
P
K
A
G
T
T
R
M
R
V
L
G
V
K
N
I
P
-
N
E
A
Q
I
I
F
L
D
T
P
G
I
Y
E
P
K
K
S
D
V
L
G
H
S
M
V
E
I
A
K
-
Q
S
L
E
E
---
A
D
V
I
L
F
M
I
D
A
T
E
G
W
R
P
R
D
E
E
-
I
Y
Q
-
N
F
-
I
K
P
L
N
K
P
V
I
V
V
I
N
K
I
D
K
I
G
P
A
K
N
--
V
L
P
L
I
D
E
I
H
K
K
HP
E
L
-
T
E
I
-------------
V
P
I
S
A
L
K
G
A
N
L
D
E
-
L
V
K
-
T
I
L
K
Y
L
P
E
G
E
P
L
F
P
E
D
M
I
T
D
-----
L
P
L
R
L
L
----
A
---
A
E
I
V
R
E
K
A
M
M
L
T
R
E
E
V
P
T
S
I
A
V
K
I
N
E
I
K
P
G
D
A
N
P
N
M
--------
L
V
I
K
G
E
I
--
I
V
D
R
E
N
L
K
-
P
I
I
-
I
G
K
K
G
Q
R
L
K
E
I
G
K
R
A
R
Q
E
L
106
HHSearch
56.54
27%
-123
- C5 -
3GEH
3
MNME_NOSS1
A:
[225-385]
-
L
K
V
A
I
V
G
R
P
N
V
G
K
S
S
L
L
N
A
W
S
Q
S
D
R
A
I
V
T
D
L
P
G
T
T
R
D
V
V
E
S
Q
L
V
V
-
G
G
I
P
V
Q
V
L
D
-------------------------
Q
A
-
A
N
-
T
A
D
L
V
L
L
T
I
D
A
A
T
-
G
W
T
T
G
D
Q
E
I
Y
E
Q
-
V
---
K
H
R
P
L
I
L
V
M
N
K
I
D
L
---
V
E
-
K
Q
-
L
---
I
T
S
L
E
Y
P
E------
N
I
T
Q
---
I
V
H
T
A
A
A
Q
K
Q
G
I
D
S
-
L
E
T
A
I
L
E
I
V
Q
T
G
K
V
Q
A
A
D
M
D
L
A
I
N
Q
R
Q
A
A
A
L
T
Q
A
K
M
S
L
E
Q
V
Q
A
T
I
T
Q
Q
L
P
L
D
F
W
T
I
D
L
R
G
A
I
Q
A
L
G
E
I
T
G
E
E
V
T
E
S
V
L
D
R
I
F
S
R
F
C
I
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
56.42
33%
-111
- C7 -
3R9X
4
ERA_AQUAE
A:
[12-177]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
K
V
S
I
I
S
P
K
A
G
T
T
R
M
R
V
L
G
V
K
N
I
P
-
N
E
A
Q
I
I
F
L
D
T
P
G
I
YE
P
K
K
S
D
V
L
G
H
S
M
V
E
I
A
K
-
Q
S
L
E
E
---
A
D
V
I
L
F
M
I
D
A
T
E
G
W
R
P
R
D
E
E
-
I
Y
Q
-
N
F
-
I
K
P
L
N
K
P
V
I
V
V
I
N
K
I
D
K
I
G
P
A
K
N
--
V
L
P
L
I
D
E
I
H
K
K
HP
E
L
-
T
E
I
-------------
V
P
I
S
A
L
K
G
A
N
L
D
E
-
L
V
K
-
T
I
L
K
Y
L
P
E
G
E
P
L
F
P
E
D
M
I
T
D
-----
L
P
L
R
L
L
----
A
---
A
E
I
V
R
E
K
A
M
M
L
T
R
E
E
V
P
T
S
I
A
V
K
I
N
E
I
K
P
G
D
A
N
P
N
M
--------
L
V
I
K
G
E
I
--
I
V
D
R
E
N
L
K
-
P
I
I
-
I
G
K
K
G
Q
R
L
K
E
I
G
K
R
A
R
Q
E
L
96
HHSearch
56.36
26%
-79
- C5 -
3IEV
4
ERA_AQUAE
A:
[8-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
V
G
Y
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
K
V
S
I
I
S
P
K
A
G
T
T
R
M
R
V
L
G
V
K
N
-
I
P
N
E
A
Q
I
I
F
L
D
T
P
G
I
--
Y
E
P
K
K
S
D
-
V
L
G
H
S
M
V
E
-
I
A
K
Q
S
L
E
E
A
D
V
I
L
F
M
I
D
A
T
E
G
W
R
P
R
D
E
E
-
I
Y
Q
-
N
F
I
K
P
L
-
N
K
P
V
I
V
V
I
N
K
I
D
K
I
G
P
-
A
K
N-
V
L
P
L
I
D
E
I
H
K
K
-----
H
--
P
E
L
-------
T
E
I
V
P
I
S
A
L
K
G
A
N
L
D
E
-
L
V
K
-
T
I
L
K
Y
L
P
E
G
E
P
L
F
P
E
D
M
I
T
D
LP
L
R
L
L
A
A
E
I
V
R
E
K
A
M
M
L
T
R
E
E
V
P
--
T
S
I
A
V
K
I
N
E
I
K
P
G
D
A
N
P
N
M
L
V
I
K
G
E
I
I
V
D
RENL
K
P
I
I
I
G
K
K
G
Q
R
L
K
E
I
G
K
R
A
R
Q
-
E
L
E
L
I
L
G
R
P
V
Y
L
E
L
W
V
K
V
V
P
D
W
R
21
PsiBlast_CBE
54.23
37%
-88
- C5 -
2DYK
2
?
B:
[1-156]
M
H
K
V
V
I
V
G
R
P
N
V
G
K
S
S
L
F
N
R
L
L
K
K
R
S
-----------
D
L
K
E
G
V
V
E
T
-
D
R
G
R
F
L
L
V
D
T
G
G
-
L
W
-
S
G
D
K
---
W
E
K
K
I
Q
-
E
K
V
D
R
A
-
L
E
-
D
A
E
V
V
L
F
A
V
D
G
R
A
-
E
L
T
Q
A
D
Y
E
V
A
E
Y
-
L
-
R
R
K
G
K
P
V
I
L
V
A
T
K
V
D
D
---
P
K
-
H
E
L
Y
---
L
G
P
L
Y
G
L
-------
G
F
G
D
---
P
I
P
T
S
S
E
H
A
R
G
L
E
E
-
L
L
E
A
I
W
E
R
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
54.11
37%
-86
- C5 -
2DYK
1
?
A:
[1-156]
M
H
K
V
V
I
V
G
R
P
N
V
G
K
S
S
L
F
N
R
L
L
K
K
R
S
-----------
D
L
K
E
G
V
V
E
T
-
D
R
G
R
F
L
L
V
D
T
G
G
-
L
W
-
S
G
D
K
---
W
E
K
K
I
Q
-
E
K
V
D
R
A
-
L
E
-
D
A
E
V
V
L
F
A
V
D
G
R
A
-
E
L
T
Q
A
D
Y
E
V
A
E
Y
-
L
-
R
R
K
G
K
P
V
I
L
V
A
T
K
V
D
D
---
P
K
-
H
E
L
Y
---
L
G
P
L
Y
G
L
-------
G
F
G
D
---
P
I
P
T
S
S
E
H
A
R
G
L
E
E
-
L
L
E
A
I
W
E
R
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
HHSearch
53.90
36%
-89
* C5 *
2DYK
1
?
A:
[1-160]
M
H
K
V
V
I
V
G
R
P
N
V
G
K
S
S
L
F
N
R
L
L
K
K
R
S
-----------
D
L
K
E
G
V
V
E
T
-
D
R
G
R
F
L
L
V
D
T
G
G
-
L
W
-
S
G
D
K
---
W
E
K
K
I
Q
-
E
K
V
D
R
A
-
L
E
-
D
A
E
V
V
L
F
A
V
D
G
R
A
-
E
L
T
Q
A
D
Y
E
V
A
E
Y
-
L
R
R
-
K
G
K
P
V
I
L
V
A
T
K
V
D
D
---
P
K
-
H
E
-
L
----
Y
L
G
P
L
Y
G
L-----
G
F
G
D
---
P
I
P
T
S
S
E
H
A
R
G
L
E
E
-
L
L
E
A
I
W
E
R
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
HHSearch
53.44
30%
-101
- C5 -
3IEV
2
ERA_AQUAE
A:
[11-184]
-
G
Y
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
K
V
S
I
I
S
P
K
A
G
T
T
R
M
R
V
L
G
V
K
N
I
P
N
E
A
Q
I
I
F
L
D
T
P
G
-
I
Y
-
E
P
K
K
SD
V
L
G
H
S
M
V
-
E
I
A
K
Q
S
-
L
E
-
E
A
D
V
I
L
F
M
I
D
A
T
E
-
G
W
R
P
R
D
E
E
I
Y
Q
N
F
I
K
P
-
L
N
K
P
V
I
V
V
I
N
K
I
D
K
---
I
G
-
P
A
-
K
NV
L
P
L
I
D
E
I
H
K
K
HP---
E
L
T
E
---
I
V
P
I
S
A
L
K
G
A
N
L
D
E
-
L
V
K
T
I
L
K
Y
L
P
E
G
E
P
L
F
P
E
D
M
I
T
D
L
P
L
R
L
L
A
A
E
I
V
R
E
K
A
M
M
L
T
R
E
E
V
P
T
S
I
A
V
K
I
N
E
I
K
P
G
D
A
N
P
N
M
L
V
I
K
G
E
I
I
V
D
R
E
N
L
K
P
I
I
I
G
K
K
G
Q
R
L
K
E
I
G
K
R
-
A
-
R
Q
E
L
E
L
I
L
G
R
P
V
Y
--
L
E
L
W
V
K
V
V
P
D
W
R
R
R
P
E
-
Y
V
R
L
F
G
Y
A
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
52.81
37%
-103
- C6 -
1XZQ
-
?
A:
[244-389]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
R
L
L
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
V
I
S
E
E
I
V
-
I
-
R
G
I
L
F
R
I
V
D
T
A
G
V
--
R
S
E
T
N
--
D
L
V
E
R
L
G
I
E
-
R
T
L
Q
E
I
E
K
A
D
I
V
L
F
V
L
D
A
S
S
P
L
D
E
E
D
R
K
-
I
L
E
--
R
-
I
K
--
N
K
R
Y
L
V
V
I
N
K
V
D
V
V
E
K
------------
I
N
E
E
--
E
I
K
N
K
L
G
T
D
-------
R
H
M
V
K
I
S
A
L
K
G
E
G
L
E
K
-
L
E
E
-
S
I
Y
R
E
T
Q
E
I
F
E
R
G
S
D
S
L
I
T
N
-----
L
R
Q
K
Q
L
----
L
---
E
N
V
K
G
H
L
E
D
A
I
K
S
L
K
E
G
M
P
V
D
M
A
S
I
D
L
E
R
A
L
N
L
L
D
E
--------
V
T
G
R
S
F
R
--
E
D
L
L
D
T
I
F
-
S
N
F
-
C
V
G
K
---------------