@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0628: (2015-12-03 )
MNDYLSLLNPEQQSAVTKVDGPVLILAGAGTGKTRTITSRIAHIIRNGYAHSDEILAVTFTNKAANEMVSRVLKLTGTNILWLGTFHAIAAKILRRHADIVGLNPNFTIIGVDDQLQVIKNIINEVSPNNLSEKHSTIMNTIQKWKEKCLLPSEVEETQLFRPIYIIALKVYHQYQERLKFLNSVDFGDLLLYNIQLFNQKTEILSYYQGKFKYIMVDEYQDTNVIQYLWLKYLAKEHSNICCVGDDDQSIYSWRGAEVKNILKFSDDFKNAKIIKLECNYRSTSHILATASYVINHNKTRLEKKLWTTNIKGEKVNLIKLWDGKAEARFISEQILKLNKYRFSDMAVLVRATFQTRVLEEYFIKYSIPYKIISGVKFYERQEVRDVIAYLRLVTNNNDDLAFERIVNRPKRSIGPTTLKKIYTVAQGNKTSFFEAAKILVNSNQVIEKIKLSLNDFFNKIKAWEEMISVKPLHKFVKTIANQSGYIEMLENEEVTGLARIENVKELISSLKNFDNATTFLEHISLVMEVDNMNNDDTVHVMTLHAAKGLEFPCVFLPGWEEGLFPHQRSFEDKSGKALEEERRLAYVGITRAKEKLIISCADRREINNQWQPMYASRFLKELPRENVEVIKSNIAYC
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70.....-.---.--.80-.........90........100.......110.......120...--....130..-...---....140.......150.......160.......------170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330...---..---.---.--340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490..-.---....---500.......510..--.---------.------.------.------.520.......530----.....--------.----...540.......550.......560.......570........580.......590.......600........610.......620.......630......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
D
Y
L
S
LL
N
P
E
Q
Q
SAVTKVDG
P
V
L
I
L
A
GAGTGK
T
R
T
I
T
S
R
I
A
H
I
I
RNGYAHS
D
E
I
L
A
V
T
FT
N
K
A
A
N
E
M
V
S
R
V
L
K
LT-G---T--
N
I
--
L
W
L
G
T
F
H
A
I
A
A
K
I
L
R
RHA
D
I
VGLNP
N
F
T
I
I
GV
D
D
Q
L
Q
V
I
K
N
I
I
N
E--VSPNN--
L
S
-
E
K
H
---
S
T
I
M
N
T
I
Q
K
W
K
E
KCLLPSEV
E
E
T
QLFR
P
I
Y
I
I
A
L
------
K
V
Y
H
Q
Y
Q
E
R
L
K
F
L
NSVDF
G
D
L
L
L
Y
N
I
Q
L
FNQ
K
T
E
I
L
S
Y
YQG
K
F
K
Y
I
M
V
DEYQD
T
N
V
I
Q
Y
L
W
L
K
Y
L
A
K
EHS
N
I
C
C
VGDDDQ
S
I
Y
SWR
G
A
E
V
K
N
I
L
K
FSDDFKN
A
K
I
I
K
L
E
C
NYRST
S
H
I
L
A
T
A
S
Y
V
INH
N
K
T
R
L
E
K
K
LWTTNIKG
E
K
V
N
L
I
K
LWDGK
A
E
A
R
F
I
S
E
Q
I
---
L
K
---
L
---
N
--KY
R
F
S
D
M
A
V
L
V
R
A
T
F
Q
T
R
V
L
E
E
Y
F
I
KYSI
P
Y
K
I
I
SG
V
K
F
Y
E
R
Q
E
V
R
D
V
I
A
Y
L
R
L
VTNNN
D
D
L
A
F
E
R
I
VNRPKRSI
G
P
T
T
L
K
K
I
Y
TVAQGNK
T
S
F
F
E
A
A
K
I
L
VN
S
N
Q
V
I
E
K
I
K
L
S
L
N
D
F
F
N
K
I
K
A
W
E
E
M
I
S
V
K
P
L
H
K
F
V
K
T
I
ANQSG
Y
I
E
M
LENEE-V---T
G
L
A
---
R
I
E
N
V
K
E
L
I
S
S
L
K
NF--D---------
N
------
A
------
T
------
T
F
L
E
H
I
S
L
V
M
EV------DNMNN--------D----D
T
V
H
V
M
T
L
HAAKGLEF
P
C
V
FLPGWEEGLFPHQRSF-EDKSGK
A
L
E
E
ER
R
L
A
Y
V
GITRAK
E
K
L
I
I
S
-CAD
R
R
EINNQW
Q
P
M
Y
A
S
R
F
L
K
EL
P
R
E
N
V
E
V
I
K
S
NIAYC
3
PsiBlast_PDB
96.80
40%
-93
- C6 -
2IS1
9
UVRD_ECOLI
A:
[7-645]
----
L
D
S
L
N
D
K
Q
R
E
A
V
A
A
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
E
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
-
G
---
T
--
S
Q
GG
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
D
A
N
L
P
Q
D
F
Q
I
L
D
S
E
D
Q
L
R
L
L
K
R
L
I
K
A
--
M
---
N
--
L
D
-
E
K
Q
WP
P
R
Q
A
M
W
Y
I
N
S
Q
K
D
E
G
L
R
P
H
H
I
Q
S
--
Y
G
N
P
V
E
Q
T
W
Q
------
K
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
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F
Q
D
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N
N
I
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Y
A
W
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L
L
A
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D
T
G
K
V
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I
V
G
D
D
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Q
S
I
Y
G
W
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G
A
Q
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N
I
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R
F
L
N
D
F
P
G
A
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T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
K
K
L
W
T
D
G
A
D
G
E
P
I
S
L
Y
C
A
F
N
E
L
D
E
A
R
F
V
V
N
R
I
K
T
-
W
Q
---
D
---
N
--
G
G
A
L
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
C
R
E
L
L
Q
E
K
A
L
A
G
R
A
A
S
A
L
Q
R
F
M
E
L
I
D
A
L
A
Q
E
T
A
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
R
T
M
Y
E
Q
E
K
-
G
E
--
K
G
Q
T
---
R
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
--
S
YNEDLM---
P
------
L
------
Q
------
A
F
L
S
H
A
A
L
--
E
A
------
G
E
G
Q
A
--------
D
TWQ-
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
E
G
M
F
P
S
Q
M
S
L
-
D
E
--
G
G
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
-
Y
A
E
T
R
R
L
Y
G
K
E
V
Y
H
R
P
S
R
F
I
G
E
L
P
E
E
C
V
E
E
V
R
L
R
A
T
V
S
5
PsiBlast_PDB
96.74
40%
-87
- C6 -
2IS6
6
UVRD_ECOLI
A:
[7-645]
----
L
D
S
L
N
D
K
Q
R
E
A
V
A
A
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
E
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
-
G
---
T
--
S
Q
GG
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
D
A
N
L
P
Q
D
F
Q
I
L
D
S
E
D
Q
L
R
L
L
K
R
L
I
K
A
--
M
---
N
--
L
D
-
E
K
Q
WP
P
R
Q
A
M
W
Y
I
N
S
Q
K
D
E
G
L
R
P
H
H
I
Q
S
--
Y
G
N
P
V
E
Q
T
W
Q
------
K
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
G
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
K
K
L
W
T
D
G
A
D
G
E
P
I
S
L
Y
C
A
F
N
E
L
D
E
A
R
F
V
V
N
R
I
K
T
-
W
Q
---
D
---
N
--
G
G
A
L
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
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G
I
G
D
R
T
L
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V
V
R
Q
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S
R
D
R
Q
L
T
L
W
Q
A
C
R
E
L
L
Q
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K
A
L
A
G
R
A
A
S
A
L
Q
R
F
M
E
L
I
D
A
L
A
Q
E
T
A
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
R
T
M
Y
E
Q
E
K
-
G
E
--
K
G
Q
T
---
R
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
--
S
Y
N
EEDLM--
P
------
L
------
Q
------
A
F
L
S
H
A
A
L
--
E
A
------
G
E
G
Q
A
--------
D
TW
Q
-
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
E
G
M
F
P
S
Q
M
S
L
-
D
E
--
G
G
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
-
Y
A
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T
R
R
L
Y
G
K
E
V
Y
H
R
P
S
R
F
I
G
E
L
P
E
E
C
V
E
E
V
R
L
R
A
T
V
S
4
PsiBlast_PDB
96.58
40%
-92
- C6 -
2IS2
2
UVRD_ECOLI
A:
[7-645]
----
L
D
S
L
N
D
K
Q
R
E
A
V
A
A
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
E
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
-
G
---
T
--
S
Q
GG
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
D
A
N
L
P
Q
D
F
Q
I
L
D
S
E
D
Q
L
R
L
L
K
R
L
I
K
A
--
M
---
N
--
L
D
-
E
K
Q
WP
P
R
Q
A
M
W
Y
I
N
S
Q
K
D
E
G
L
R
P
H
H
I
Q
S
--
Y
G
N
P
V
E
Q
T
W
Q
------
K
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
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E
L
W
L
N
K
P
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I
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Q
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Y
R
E
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F
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L
V
D
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Q
D
T
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N
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Q
Y
A
W
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L
L
A
G
D
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K
V
M
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G
D
D
D
Q
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Y
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W
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G
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F
L
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N
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K
K
L
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A
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N
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Q
---
D
---
N
--
G
G
A
L
A
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A
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N
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L
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A
L
L
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Y
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G
G
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N
D
D
A
A
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V
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I
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D
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V
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L
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Q
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C
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L
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A
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M
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E
T
A
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
R
T
M
Y
E
Q
E
K
-
G
E
--
K
G
Q
T
---
R
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
--
S
YDEDLM---
P
------
L
------
Q
------
A
F
L
S
H
A
A
L
--
E
A
------
G
E
G
Q
A
--------
D
TWQ-
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
E
G
M
F
P
S
Q
M
S
L
-
D
E
--
G
G
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
-
Y
A
E
T
R
R
L
Y
G
K
E
V
Y
H
R
P
S
R
F
I
G
E
L
P
E
E
C
V
E
E
V
R
L
-----
1
PsiBlast_PDB
95.36
42%
-89
- C6 -
3PJR
2
?
A:
[9-642]
----
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
-
G
GA-
A
--
E
D
--
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
R
N
F
S
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
K
N
I
D
P
K
K
--
F
E
-
P
R
-----
T
I
L
G
T
I
S
A
A
K
N
E
L
L
P
P
E
Q
F
A
K
R
A
S
T
Y
Y
E
K
V
V
S
-------
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
I
W
T
E
N
P
E
G
K
P
I
L
Y
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
---
R
---
G
--
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
K
L
V
R
Y
A
A
D
H
E
L
S
L
F
E
A
L
G
E
L
-
E
M
I
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
E
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
K
A
E
R
T
I
---
E
A
Q
S
---
R
L
E
N
L
D
E
F
L
S
V
T
K
H
F
--
E
---------
N
------
V
------
S
DDKS
L
I
A
F
L
T
D
L
A
L
I
S
D
L
------
D
E
---TEQAAE--
G
----
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
L
---
E
D
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
-
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
P
A
H
L
L
E
T
A
S
R
R
----
21
PsiBlast_CBE
95.28
40%
-92
- C6 -
2IS1
7
UVRD_ECOLI
B:
[7-644]
----
L
D
S
L
N
D
K
Q
R
E
A
V
A
A
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
E
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
-
G
---
T
--
S
Q
GG
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
D
A
N
L
P
Q
D
F
Q
I
L
D
S
E
D
Q
L
R
L
L
K
R
L
I
K
A
--
M
---
N
--
L
D
-
E
K
Q
WP
P
R
Q
A
M
W
Y
I
N
S
Q
K
D
E
G
L
R
P
H
H
I
Q
S
------
V
E
Q
T
W
Q
------
K
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
G
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
K
K
L
W
T
D
G
A
D
G
E
P
I
S
L
Y
C
A
F
N
E
L
D
E
A
R
F
V
V
N
R
I
K
T
-
W
Q
---
D
---
N
--
G
G
A
L
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
C
R
E
L
L
Q
E
K
A
L
A
G
R
A
A
S
A
L
Q
R
F
M
E
L
I
D
A
L
A
Q
E
T
A
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
R
T
M
Y
E
Q
E
K
-
G
E
--
K
G
Q
T
---
R
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
--
S
YDEDLM---
P
------
L
------
Q
------
A
F
L
S
H
A
A
L
--
E
A
------
G
E
G
-----------Q---
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
E
G
M
F
P
S
Q
M
---------
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
-
Y
A
E
T
R
R
L
Y
G
K
E
V
Y
H
R
P
S
R
F
I
G
E
L
P
E
E
C
V
E
E
V
-------
33
HHSearch
94.89
44%
-87
- C6 -
1PJR
-
PCRA_GEOSE
A:
[6-649]
-
E
Q
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
-
G
---
G
AA
E
D
--
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
R
N
F
S
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
--
K
N
I
-
D
--
P
K
K
F
E
P
---
R
T
I
L
G
T
I
S
A
A
K
N
E
L
L
P
P
E
Q
F
A
K
R
----
Y
Y
E
K
V
V
S
------
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
I
W
T
E
N
P
E
G
K
P
I
L
Y
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
---
R
E
---
A
V
E
R
G
--
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
------------
L
F
E
A
L
G
E
L
E
M
I
-
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
E
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
K
A
E
R
-
T
I
--
E
A
Q
S
---
R
L
E
N
L
D
E
F
L
S
V
T
K
H
F
--
E
---------
N
V
SDDKS
L
------
I
------
A
F
L
T
D
L
A
L
I
S
---------------------
G
----
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
L
-
E
--
D
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
-
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
P
A
H
L
L
E
T
A
S
R
-----
26
PsiBlast_CBE
94.71
38%
-83
- C6 -
4C2U
8
?
D:
[8-648]
--
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
G
---
A
--
G
D
--
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
--
I
P
G
-----
E
-
T
Q
P
---
R
V
I
R
G
I
I
D
R
A
K
S
N
L
W
T
P
D
D
L
D
R
S
---
R
E
P
F
I
S
G
L
PRDAAA
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
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D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
D
R
N
L
L
V
V
G
D
P
D
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S
I
Y
K
F
R
G
A
D
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N
I
L
D
F
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D
Y
P
D
A
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V
Y
M
L
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N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
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L
D
K
T
L
K
P
V
K
E
A
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Q
P
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A
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D
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R
A
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D
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V
A
D
W
L
---
T
R
---
L
---
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GE
G
R
A
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A
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G
G
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L
A
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A
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N
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V
A
L
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R
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R
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R
R
G
I
G
D
T
A
L
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K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
A
E
Q
N
-
I
L
D
R
G
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
G
-
Q
---
E
G
Q
V
---
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
SQ
D
---------
E
------
A
NVGGSI
A
------
D
F
L
D
D
A
A
L
L
S
S
V
------
D
D
M
R
T
KAENKGAP
E
----
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
E
G
P
S
G
--
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
-
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
E
G
L
F
D
T
V
D
P
Y
G
Q
P
I
E
7
PsiBlast_PDB
94.53
38%
-83
- C6 -
4C2U
8
?
A:
[8-648]
--
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
G
---
A
--
G
D
--
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
--
I
P
G
-----
E
-
T
Q
P
---
R
V
I
R
G
I
I
D
R
A
K
S
N
L
W
T
P
D
D
L
D
R
S
---
R
E
P
F
I
S
G
L
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
D
R
N
L
L
V
V
G
D
P
D
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S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
D
A
K
V
Y
M
L
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N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
L
K
P
V
K
E
A
G
Q
P
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
---
T
R
---
L
---
H
G
E
G
R
A
W
S
E
M
A
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L
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R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
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Q
I
P
A
R
I
V
G
G
V
G
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Y
D
R
R
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L
A
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A
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L
A
L
N
P
A
D
D
V
A
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R
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R
P
R
R
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I
G
D
T
A
L
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L
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W
A
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T
H
H
T
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V
L
T
A
C
A
N
A
A
E
Q
N
-
I
L
D
R
G
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
G
-
Q
---
E
G
Q
V
---
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
S
Q
D
---------
E
------
A
NVGGS
I
A
------
D
F
L
D
D
A
A
L
L
S
S
V
------
D
D
M
R
T
K
A
E
N
KGAP
E
----
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
E
G
P
S
G
--
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
-
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
E
G
L
F
D
T
V
D
P
Y
G
Q
P
I
E
8
PsiBlast_PDB
94.49
38%
-82
- C6 -
4C30
5
?
A:
[8-648]
--
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
G
---
A
--
G
D
--
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
--
I
P
G
I
G
--
A
E
-
T
Q
P
---
R
V
I
R
G
I
I
D
R
A
K
S
N
L
W
T
P
D
D
L
D
R
S
---
R
E
P
-----P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
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V
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
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D
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Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
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R
D
R
N
L
L
V
V
G
D
P
D
Q
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I
Y
K
F
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A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
L
K
P
V
K
E
A
G
Q
P
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
---
T
R
---
L
---
H
G
E
G
R
A
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
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E
S
L
R
R
V
Q
I
P
A
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I
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G
G
V
G
F
Y
D
R
R
E
I
R
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I
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A
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A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
-----------
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
G
-
Q
---
E
G
Q
V
---
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
S
Q
D
---------
E
------
A
I-----
A
------
D
F
L
D
D
A
A
L
L
S
S
V
------
D
D
M
R
T
KAEP----
E
----
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
E
G
P
S
G
--
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
-
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
E
G
L
F
D
T
V
D
P
Y
G
Q
P
--
27
PsiBlast_CBE
94.37
38%
-82
- C6 -
4C2T
2
?
C:
[8-648]
--
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
G
---
A
--
G
D
--
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
--
I
P
G
I
G
--
A
E
-
T
Q
P
---
R
V
I
R
G
I
I
D
R
A
K
S
N
L
W
T
P
D
D
L
D
R
S
---
R
E
P
F
I
S
G
L
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
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R
L
F
K
E
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P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
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Y
E
L
T
R
L
L
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R
D
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L
L
V
V
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D
P
D
Q
S
I
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F
R
G
A
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I
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N
I
L
D
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K
D
Y
P
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A
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V
Y
M
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N
Y
R
S
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A
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L
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A
A
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K
L
I
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T
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R
L
D
K
T
L
K
P
V
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A
G
Q
P
V
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F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
---
T
R
---
L
---
H
G
E
G
R
A
W
S
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M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
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E
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L
R
R
V
Q
I
P
-
R
I
V
G
G
V
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F
Y
D
R
R
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I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
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R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
A
E
Q
N
-
I
L
D
R
G
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
------
E
G
Q
V
---
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
S
Q
D
---------
E
------
A
NSI---
A
------
D
F
L
D
D
A
A
L
L
S
S
V
------
D
D
M
R
T
K
A
EP----
E
----
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
E
G
P
S
G
--
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
-
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
E
G
L
F
D
T
V
D
P
Y
G
Q
P
I
-
9
PsiBlast_PDB
93.75
38%
-80
- C6 -
4C2T
4
?
A:
[8-648]
--
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
G
---
A
--
G
D
--
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
--
I
P
G
I
G
--
A
E
-
T
Q
P
---
R
V
I
R
G
I
I
D
R
A
K
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N
L
W
T
P
D
D
L
D
R
S
---
R
E
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F
I
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G
L
P
R
D
A
A
A
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A
Y
R
R
Y
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V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
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T
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R
L
F
K
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P
G
V
L
D
K
V
Q
N
K
A
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F
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D
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N
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A
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Y
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L
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L
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L
L
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P
D
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I
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A
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I
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D
Y
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A
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M
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N
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R
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A
R
V
L
E
A
A
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K
L
I
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T
L
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A
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---
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---
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---
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A
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L
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A
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H
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V
L
T
A
C
A
N
A
A
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Q
N
-
I
L
D
R
G
A
H
K
A
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F
A
G
L
M
E
A
M
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A
A
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N
Y
E
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A
A
F
L
R
F
V
M
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T
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G
Y
L
D
L
L
R
Q
E
G
-
Q
---
E
G
Q
V
---
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
S
Q
D
---------
E
------
A
NVGGS
I
A
------
D
F
L
D
D
A
A
L
L
S
S
--------
D
M
R
T
KA------
E
----
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
E
G
P
S
G
--
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
-
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
E
G
L
F
D
T
V
D
P
Y
G
Q
P
I
-
24
PsiBlast_CBE
93.66
38%
-79
- C6 -
4C30
5
?
F:
[8-648]
--
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
G
---
A
--
G
D
--
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
--
I
P
G
I
G
--
A
E
-
T
Q
P
---
R
V
I
R
G
I
I
D
R
A
K
S
N
L
W
T
P
D
D
L
D
R
S
---
R
E
P
-----PRDAAA
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
L
K
P
V
K
E
A
G
Q
P
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
---
T
R
---
L
---
H
GE
G
R
A
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
-----------
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
G
-
Q
---
E
G
Q
V
---
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
SQ
D
---------
E
------
A
I-----
A
------
D
F
L
D
D
A
A
L
L
S
S
V
------
D
D
M
R
T
KAEP----
E
----
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
E
G
P
S
G
--
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
-
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
E
G
L
F
D
T
V
D
P
Y
G
Q
P
I
-
23
PsiBlast_CBE
93.61
38%
-84
- C6 -
4C30
3
?
I:
[8-648]
--
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
G
---
A
--
G
D
--
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
--
I
P
G
-----
E
-
T
Q
P
---
R
V
I
R
G
I
I
D
R
A
K
S
N
L
W
T
P
D
D
L
D
R
S
---
R
E
P
F
I
S
G
L
PRDAAA
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
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N
I
L
D
F
Q
K
D
Y
P
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
L
K
P
V
K
E
A
G
Q
P
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
---
T
R
---
L
---
H
GE
G
R
A
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
----
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
A
E
Q
N
-
I
L
D
R
G
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
G
-
Q
---
E
G
Q
V
---
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
SQ
D
---------
E
------
A
GSI---
A
------
D
F
L
D
D
A
A
L
L
S
S
V
------
D
D
---GAP-----
E
----
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
E
G
P
S
G
--
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
-
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
E
G
L
F
D
T
V
D
P
Y
G
Q
P
I
-
25
PsiBlast_CBE
93.25
38%
-85
- C6 -
4C30
3
?
D:
[8-648]
--
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
G
---
A
--
G
D
--
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
--
I
P
G
-----
E
-
T
Q
P
---
R
V
I
R
G
I
I
D
R
A
K
S
N
L
W
T
P
D
D
L
D
R
S
---
R
E
P
F
I
S
G
L
PRDAAA
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
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D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
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I
L
D
F
Q
K
D
Y
P
D
A
K
V
Y
M
L
E
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N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
L
K
P
V
K
E
A
G
Q
P
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
---
T
R
---
L
---
H
GE
G
R
A
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
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D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
A
E
Q
N
-
I
L
D
R
G
A
H
K
A
T
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A
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L
M
E
A
M
S
E
A
A
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N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
G
-
Q
---
E
G
Q
V
---
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
SQ
D
---------
E
------
A
GSI---
A
------
D
F
L
D
D
A
A
L
L
S
S
V
------
D
D
---GAP-----
E
----
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
E
G
P
S
G
--
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
-
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
E
G
L
F
D
T
V
D
P
Y
G
Q
P
I
-
2
PsiBlast_PDB
93.14
42%
-87
- C6 -
1PJR
-
PCRA_GEOSE
A:
[9-642]
----
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
-
G
GA-
A
--
E
D
--
V
W
I
S
T
F
H
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M
C
V
R
I
L
R
R
D
I
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R
I
G
I
N
R
N
F
S
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
KN
I
D
P
K
K
--
F
E
-
P
R
-----
T
I
L
G
T
I
S
A
A
K
N
E
L
L
P
P
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Q
F
A
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R
---
Y
Y
E
K
V
V
S
-------
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
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L
D
F
D
D
L
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M
T
T
I
Q
L
F
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L
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Y
Y
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R
A
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Y
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L
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K
K
L
A
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F
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C
A
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D
A
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---
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D
L
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L
L
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G
I
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A
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T
I
D
------------
L
F
E
A
L
G
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L
-
E
M
I
G
L
G
A
K
A
A
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A
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A
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L
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L
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L
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A
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I
---
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A
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---
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L
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L
D
E
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L
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T
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H
F
--
E
---------
N
------
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------
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DDKS
L
I
A
F
L
T
D
L
A
L
I
S
---------------------
G
----
D
A
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M
L
M
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L
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A
A
K
G
L
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F
L
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M
E
E
G
I
F
P
H
N
R
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L
---
E
D
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
-
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
P
A
H
L
L
E
T
A
S
R
-----
35
HHSearch
90.16
37%
-86
- C6 -
1UAA
1
REP_ECOLI
A:
[2-640]
------
R
L
N
P
G
Q
Q
Q
A
V
E
F
V
T
G
P
C
L
V
L
A
G
A
G
S
G
K
T
R
V
I
T
N
K
I
A
H
L
I
R
G
C
G
Y
Q
A
R
H
I
A
A
V
T
F
T
N
K
A
A
R
E
M
K
E
R
V
G
Q
T
L
-
G
RKE
A
--
R
G
--
L
M
I
S
T
F
H
T
L
G
L
D
I
I
K
R
E
Y
A
A
L
G
M
K
A
N
F
S
L
F
D
D
T
D
Q
L
A
L
L
K
E
L
T
E
G
--
L
I
E
-
D
--
D
K
-
V
L
L
---
Q
Q
L
I
S
T
I
S
N
W
K
N
D
L
K
T
P
S
Q
A
A
A
S
A
-
I
G
E
R
D
R
I
F
A
------
H
C
Y
G
L
Y
D
A
H
L
K
A
C
N
V
L
D
F
D
D
L
I
L
L
P
T
L
L
L
Q
A
N
E
E
V
R
K
R
W
Q
N
K
I
R
Y
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
R
A
R
F
T
V
V
G
D
D
D
Q
S
I
Y
S
W
R
G
A
R
P
Q
N
L
V
L
L
S
Q
D
F
P
A
L
K
V
I
K
L
E
Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
N
P
H
V
F
E
K
R
L
F
S
E
L
G
Y
G
A
E
L
K
V
L
S
A
N
N
E
E
H
E
A
E
R
V
T
G
E
L
---
I
A
---
H
H
F
V
N
--
K
T
Q
Y
K
D
Y
A
I
L
Y
R
G
N
H
Q
S
R
V
F
E
K
F
L
M
Q
N
R
I
P
Y
K
I
S
G
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
L
R
I
V
N
T
P
K
R
E
I
G
P
A
T
L
K
K
L
G
E
W
A
M
T
R
N
K
S
M
F
T
A
S
F
D
M
G
L
S
Q
T
L
S
G
R
G
Y
E
A
L
T
R
F
T
H
W
L
A
E
I
Q
R
L
-
A
E
R
E
P
I
A
A
V
R
D
L
I
H
G
M
D
Y
E
S
W
L
Y
E
T
S
-
P
S
P
K
A
A
E
M
---
R
M
K
N
V
N
Q
L
F
S
W
M
T
E
M
--
L
E
GSELDEPM
T
------
L
------
T
------
Q
V
V
T
R
F
T
L
R
D
M
M
ER------
E
E
E
--------
L
----
D
Q
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
V
Y
M
V
G
M
E
E
G
F
L
P
H
Q
S
S
I
----
D
E
D
N
I
D
E
E
R
R
L
A
Y
V
G
I
T
R
A
Q
K
E
L
T
F
T
-
L
C
K
E
R
R
Q
Y
G
E
L
V
R
P
E
P
S
R
F
L
L
E
L
P
Q
D
D
L
I
W
--------
10
PsiBlast_PDB
88.37
37%
-83
- C6 -
1UAA
1
REP_ECOLI
A:
[3-638]
-------
L
N
P
G
Q
Q
Q
A
V
E
F
V
T
G
P
C
L
V
L
A
G
A
G
S
G
K
T
R
V
I
T
N
K
I
A
H
L
I
R
G
C
G
Y
Q
A
R
H
I
A
A
V
T
F
T
N
K
A
A
R
E
M
K
E
R
V
G
Q
T
L
-
G
RKE
A
--
R
G
--
L
M
I
S
T
F
H
T
L
G
L
D
I
I
K
R
E
Y
A
A
L
G
M
K
A
N
F
S
L
F
D
D
T
D
Q
L
A
L
L
K
E
L
T
E
G
--
L
I
E
D
D
K
V
L
L
-
Q
Q
------
L
I
S
T
I
S
N
W
K
N
D
L
K
T
P
S
Q
A
A
A
S
A
I
G
E
R
D
R
I
F
A
-------
H
C
Y
G
L
Y
D
A
H
L
K
A
C
N
V
L
D
F
D
D
L
I
L
L
P
T
L
L
L
Q
A
N
E
E
V
R
K
R
W
Q
N
K
I
R
Y
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
R
A
R
F
T
V
V
G
D
D
D
Q
S
I
Y
S
W
R
G
A
R
P
Q
N
L
V
L
L
S
Q
D
F
P
A
L
K
V
I
K
L
E
Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
N
P
H
V
F
E
K
R
L
F
S
E
L
G
Y
G
A
E
L
K
V
L
S
A
N
N
E
E
H
E
A
E
R
V
T
G
E
L
---
I
A
H
H
F
V
---
N
--
K
T
Q
Y
K
D
Y
A
I
L
Y
R
G
N
H
Q
S
R
V
F
E
K
F
L
M
Q
N
R
I
P
Y
K
I
S
G
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
L
R
I
V
N
T
P
K
R
E
I
G
P
A
T
L
K
K
L
G
E
W
A
M
T
R
N
K
S
M
F
T
A
S
F
D
M
G
L
S
Q
T
L
S
G
R
G
Y
E
A
L
T
R
F
T
H
W
L
A
E
I
Q
R
L
A
E
R
E
P
I
A
A
-
V
R
D
L
I
H
G
M
D
Y
E
S
W
L
Y
E
T
S
-
P
---
S
P
K
A
A
E
M
R
M
K
N
V
N
Q
L
F
S
W
M
T
E
M
--
L
---------
E
------
G
------
S
------
E
L
D
E
P
M
T
L
T
Q
V
V
T
R
F
T
L
R
D
M
M
E
R
---------EEEL
D
Q
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
V
Y
M
V
G
M
E
E
G
F
L
P
H
Q
S
S
I
-
D
E
D
N
---
I
D
E
E
R
R
L
A
Y
V
G
I
T
R
A
Q
K
E
L
T
F
T
L
C
K
E
R
R
Q
Y
G
E
L
V
R
P
-
E
P
S
R
F
L
L
E
L
P
Q
D
D
L
I
W
--------
28
PsiBlast_CBE
86.96
37%
-82
* C6 *
1UAA
1
REP_ECOLI
B:
[3-638]
-------
L
N
P
G
Q
Q
Q
A
V
E
F
V
T
G
P
C
L
V
L
A
G
A
G
S
G
K
T
R
V
I
T
N
K
I
A
H
L
I
R
G
C
G
Y
Q
A
R
H
I
A
A
V
T
F
T
N
K
A
A
R
E
M
K
E
R
V
G
Q
T
L
-
G
RKE
A
--
R
G
--
L
M
I
S
T
F
H
T
L
G
L
D
I
I
K
R
E
Y
A
A
L
G
M
K
A
N
F
S
L
F
D
D
T
D
Q
L
A
L
L
K
E
L
T
E
G
--
L
I
E
D
D
KV
L
L
-
Q
Q
------
L
I
S
T
I
S
N
W
K
N
D
L
K
T
P
S
Q
A
A
A
S
A
I
G
E
R
D
R
I
F
A
-------
H
C
Y
G
L
Y
D
A
H
L
K
A
C
N
V
L
D
F
D
D
L
I
L
L
P
T
L
L
L
Q
A
N
E
E
V
R
K
R
W
Q
N
K
I
R
Y
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
R
A
R
F
T
V
V
G
D
D
D
Q
S
I
Y
S
W
R
G
A
R
P
Q
N
L
V
L
L
S
Q
D
F
P
A
L
K
V
I
K
L
E
Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
N
P
H
V
F
E
K
R
L
F
S
E
L
G
Y
G
A
E
L
K
V
L
S
A
N
N
E
E
H
E
A
E
R
V
T
G
E
L
---
I
A
HHF
V
---
N
--
K
T
Q
Y
K
D
Y
A
I
L
Y
R
G
N
H
Q
S
R
V
F
E
K
F
L
M
Q
N
R
I
P
Y
K
I
S
G
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
L
R
I
V
N
T
P
K
R
E
I
G
P
A
T
L
K
K
L
G
E
W
A
M
T
R
N
K
S
M
F
T
A
S
F
D
M
G
L
S
Q
T
L
S
G
R
G
Y
E
A
L
T
R
F
T
H
W
L
A
E
I
Q
R
L
A
E
R
E
P
I
A
A
-
V
R
D
L
I
H
G
M
D
Y
E
S
W
L
Y
E
T
S
-
P
---
S
P
K
A
AEM
R
M
K
N
V
N
Q
L
F
S
W
M
T
E
M
--
L
---------
E
------
G
------
S
------
E
L
D
E
P
M
T
L
T
Q
V
V
TRFTLR
D
-------------EEL-
D
Q
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
V
Y
M
V
G
M
E
E
G
F
L
P
H
Q
S
S
I
-
D
E
D
N
---
I
D
E
E
R
R
L
A
Y
V
G
I
T
R
A
Q
K
E
L
T
F
T
L
C
K
E
R
R
Q
Y
G
E
L
V
R
P
-
E
P
S
R
F
L
L
E
L
P
Q
D
D
L
I
W
E
Q
------
6
PsiBlast_PDB
84.09
40%
-87
- C6 -
2PJR
2
?
A:
[9-548]
----
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
-
G
GA-
A
--
E
D
--
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
R
N
F
S
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
KN
I
D
P
K
K
--
F
E
-
P
R
-----
T
I
L
G
T
I
S
A
A
K
N
E
L
L
P
P
E
Q
F
A
K
R
A
S
T
Y
Y
E
K
V
V
S
-------
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
I
W
T
E
N
P
E
G
K
P
I
L
Y
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
---
R
---
G
--
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
K
L
V
R
Y
A
A
D
H
E
L
S
L
F
E
A
L
G
E
L
-
E
M
I
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
E
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
K
A
E
R
T
I
---
E
A
Q
S
---
R
L
E
N
L
D
E
F
L
S
V
T
K
H
F
--
E
---------
N
------
V
------
S
DDKS
L
I
A
F
L
T
D
L
A
L
I
S
D
L
------
D
E
L
D
----------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
83.93
40%
-90
- C6 -
2PJR
3
?
F:
[9-547]
----
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
-
G
GA-
A
--
E
D
--
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
R
N
F
S
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
KN
I
D
P
K
K
--
F
E
-
P
R
-----
T
I
L
G
T
I
S
A
A
K
N
E
L
L
P
P
E
Q
F
A
K
R
A
S
T
Y
Y
E
K
V
V
S
-------
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
I
W
T
E
N
P
E
G
K
P
I
L
Y
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
REA
V
E
---
R
---
G
--
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
K
L
V
R
Y
A
A
D
H
E
L
S
L
F
E
A
L
G
E
L
-
E
M
I
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
E
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
K
A
E
R
T
I
---
E
A
Q
S
---
R
L
E
N
L
D
E
F
L
S
V
T
K
H
F
--
E
---------
N
------
V
------
S
DDKSLI
A
F
L
T
D
L
A
L
I
S
D
L
------
D
E
L
-----------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
39.54
58%
-26
- C6 -
2PJR
2
?
G:
[2-92]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
L
-
E
D
D
D
--
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
-
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
P
A
H
L
L
E
T
A
S
------
32
PsiBlast_CBE
36.97
58%
-30
- C6 -
2PJR
2
?
B:
[2-92]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
L
-
E
D
D
D
--
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
-
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
P
A
H
L
L
E
T
A
S
------