@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0796: (2015-12-04 )
MFKTKLSLLLIAVFLLNIDFLLSCPVFADGVSGTDKTEFVSRFSSAGSFSRASNPDCGAFKTAAAIAGIAIAVGAVWTGIVLIFSSSGLFTALVIVGMIAAIVGVWKAIGGLVVCEHSFVRHPVARDHDGEYKDFALLDGGYADCTNKNYQKEDEYFSCLQNKTRKNANKEDYDRKRAEREALNPNVQNNTGNYYWPKNSVQYSEYIEVCHRNPLTFGNLFKKEDFDRRGEDKYINFDVREKDTGYVDGSWSPKVDGDLDCKVLKAGQSKTIHGSTFKALRKMGRLCVELASISTLGISMTPWPQGVDMGCTELPPDPLAPMCDESKMKFKNKGGIIITDPNPIKDLLKGNESKDYKTLIREREEKKEIFVGYDNKGCFSSYVSEACHNQAGSKSLAPIPITSMIVQCIKESLDNLVAGKGTPNGESFISVAQERLKNTITAVLVLALILFSIKAMSGGVHSPQEMYMLIIKFALVIYFTTGNTMSHYYGELTKLSNGLSEIVLKASSESKGICNYEAKDYKNDTTNYSYLAPWDRLDCRILFYLGAPLDGIAGKIGTGDVGILAILLGAAPALLVAGSVIGIICAGGQILVALVAIFMAIMMMMVILWMCYVFILSLIALSIIIILSPLFIPMVLFQHTKGYFDGWLRELITYSLYPVMLFAFLSFMFIACDKIYFKNLHFEKEEKIKILGNEKQWFKLKSGECDKNENTLACMMQNYKWEKSNILGLFDFTYMEFGNSLIGELLKLALILFLFYHFLNILPDMAAELSGNHRAALGSGATPGKMMSKAFSVAKAIAGAVGKAHSGDAAGAAKEAQKARDDSRALASGNADDKSGRSPATVGSEAANATGEAIRGTADAAQSAASEAANSTES
Atome Classification :
(20 SA)
.........10........20........30........40..---......50.----...---....60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330-.......340.......350......----.-360.......370.......380.......390........400.......410.......420--.......430.-......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.---......560.......570.......580.......590...-----....600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MF
K
T
K
L
S
L
L
L
I
A
V
F
L
L
N
I
D
F
L
LSCPVFADGVSGT
D
K
T
E
F
V
S
R
F
---SSAGSFSRA----SNP---DC
G
A
F
K
T
A
A
A
I
A
G
I
A
I
A
V
G
A
V
W
T
G
I
V
L
I
FSSS
G
L
F
T
A
L
V
I
V
G
M
I
A
A
I
V
G
V
W
K
AIG
G
L
V
V
CEHSFVRHPVARDHDGEYK
D
F
A
L
LDGGYADCTNKNYQ
K
E
D
E
Y
F
S
C
L
Q
N
K
TRKNAN
K
E
D
Y
D
R
K
R
A
E
R
EALNPNVQNNTGNYYWPKNSV
Q
Y
S
E
Y
I
E
V
C
HRNPL
T
F
G
N
L
F
K
K
E
DFDRRGED
K
Y
I
N
F
D
VREKDTGYVDGSWSPKVDGDLD
C
K
V
LKAGQSKTIH
G
S
T
F
K
A
L
R
K
M
G
R
L
C
V
E
L
A
S
I
S
T
LGISMTPWPQGVDMGCTELPPDPLAPMC
D
E
S
K
MKFKN-KG
G
I
I
I
TDP
N
P
I
K
D
L
LKGNES
K
D
Y
K
T
----
L
-
I
R
E
R
E
EKK
E
I
F
V
G
YDNK
G
C
F
S
S
Y
V
S
E
A
C
HNQ-AGSKSLAPI
P
I
T
S
M
I
V
Q
C
I
K
E
S
L
D
N
L
VAGKGT--PN
G
E
S
F
I
S
V
A
Q
-
E
R
L
K
N
T
I
T
A
V
L
V
L
A
L
I
L
F
S
I
K
A
MSGGVH
S
P
Q
E
M
Y
M
L
I
I
K
F
A
L
V
I
Y
F
TTGN
T
M
S
H
Y
Y
G
E
L
T
K
L
SN
G
L
S
E
I
V
LKASSESKGICNYEAKDYKNDTTNYSYLAPWDRL
D
C
R
I
L
F
Y
LGAPLDGIA---GKIGTG
D
V
G
I
L
A
I
L
L
GA
A
P
A
L
L
V
AG
S
V
I
G
I
I
CAG
G
Q
I
L
V
A
L
V
-----
A
I
F
M
A
I
M
M
M
M
V
I
L
W
M
C
Y
V
F
I
L
S
L
I
A
L
S
I
I
I
I
L
S
P
L
F
I
P
M
V
L
F
Q
HT
K
G
Y
F
D
G
W
L
R
E
L
I
T
Y
S
L
Y
P
V
M
L
F
A
F
L
S
F
M
F
I
A
C
D
K
I
Y
F
K
NLHFEKE
E
K
I
K
I
LGNE
K
Q
W
F
K
LKSGECDKNE
N
T
L
A
C
M
M
QNYKWEKS
N
I
L
G
L
F
D
F
T
Y
M
E
F
G
N
S
L
I
G
E
L
L
K
L
A
L
I
L
F
L
F
Y
H
F
L
N
I
L
P
D
M
A
A
E
LSGNHRAALGSGAT
P
G
K
M
M
S
K
A
F
S
V
A
K
A
I
A
G
AVGKAHSGDAAG
A
A
K
E
A
Q
K
ARDD
S
R
ALASGNADDKSGRSPATVGSEAANATG
E
A
IRG
T
A
D
A
A
Q
S
A
A
S
EAANSTES
16
PsiBlast_PDB
77.12
27%
47
- C6 -
1Y0E
1
NANE_STAAN
A:
[4-134]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
G
L
I
V
S
C
Q
A
L
P
D
E
P
L
H
S
S
F
I
M
S
K
M
A
L
A
A
Y
E
G
G
A
V
G
I
R
A
N
T
K
E
D
I
L
A
I
K
E
T
V
D
L
P
V
----
I
G
I
V
K
R
D
--------
Y
D
H
S
D
V
F
I
T
A
T
S
K
E
V
D
E
L
-
I
E
S
Q
C
E
V
-
I
A
L
D
A
T
L
Q
Q
R
P
K
E
T
L
D
E
L
V
S
Y
I
R
T
HA
P
N
V
E
I
M
A
D
I
A
T
V
E
E
A
K
N
A
A
R
L
G
F
D
Y
I
G
T
T
L
H
G
Y
T
S
Y
T
Q
G
Q
L
L
Y
Q
N
D
F
Q
F
L
K
D
V
L
Q
S
V
D
A
K
V
I
A
E
G
N
V
I
T
P
D
M
Y
K
R
V
M
D
L
G
V
H
C
S
V
V
G
G
A
I
T
R
P
K
E
I
T
K
R
F
V
Q
V
M
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
62.90
41%
217
- C6 -
4FLO
-
AMYS_NEIPO
A:
[408-458]
-----------------------------
G
I
S
G
Y
D
H
R
Q
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
Y
N
P
STG
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
D
D
W
S
Q
D
S
N
K
S
D
D
S
R
W
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
D
G
G
R
L
V
T
F
N
T
N
N
K
H
I
I
G
Y
I
R
N
N
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
A
M
P
F
K
A
H
D
L
I
G
G
K
T
V
S
L
N
Q
D
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
61.52
41%
219
- C6 -
1G5A
1
AMYS_NEIPO
A:
[408-458]
-----------------------------
G
I
S
G
Y
D
H
R
Q
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
Y
N
P
STG
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
D
D
W
S
Q
D
S
N
K
S
D
D
S
R
W
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
D
G
G
R
L
V
T
F
N
T
N
N
K
H
I
I
G
Y
I
R
N
N
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
A
M
P
F
K
A
H
D
L
I
G
G
K
T
V
S
L
N
Q
D
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
61.44
41%
222
- C6 -
1MW3
1
AMYS_NEIPO
A:
[408-458]
-----------------------------
G
I
S
G
Y
D
H
R
Q
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
Y
N
P
STG
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
D
D
W
S
Q
D
S
N
K
S
D
D
S
R
W
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
D
G
G
R
L
V
T
F
N
T
N
N
K
H
I
I
G
Y
I
R
N
N
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
A
M
P
F
K
A
H
D
L
I
G
G
K
T
V
S
L
N
Q
D
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
61.31
41%
215
- C6 -
3UEQ
-
AMYS_NEIPO
A:
[412-462]
-----------------------------
G
I
S
G
Y
D
H
R
Q
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
Y
N
P
STG
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
D
D
W
S
Q
D
S
N
K
S
D
D
S
R
W
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
D
G
G
R
L
V
T
F
N
T
N
N
K
H
I
I
G
Y
I
R
N
N
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
A
M
P
F
K
A
H
D
L
I
G
G
K
T
V
S
L
N
Q
D
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
60.89
41%
214
- C6 -
1MW1
1
AMYS_NEIPO
A:
[408-458]
-----------------------------
G
I
S
G
Y
D
H
R
Q
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
Y
N
P
STG
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
D
D
W
S
Q
D
S
N
K
S
D
D
S
R
W
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
D
G
G
R
L
V
T
F
N
T
N
N
K
H
I
I
G
Y
I
R
N
N
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
A
M
P
F
K
A
H
D
L
I
G
G
K
T
V
S
L
N
Q
D
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
60.78
41%
215
- C6 -
1MVY
1
AMYS_NEIPO
A:
[408-458]
-----------------------------
G
I
S
G
Y
D
H
R
Q
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
Y
N
P
STG
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
D
D
W
S
Q
D
S
N
K
S
D
D
S
R
W
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
G
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
D
G
G
R
L
V
T
F
N
T
N
N
K
H
I
I
G
Y
I
R
N
N
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
A
M
P
F
K
A
H
D
L
I
G
G
K
T
V
S
L
N
Q
D
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
60.54
41%
220
- C6 -
1S46
-
AMYS_NEIPO
A:
[408-458]
-----------------------------
G
I
S
G
Y
D
H
R
Q
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
Y
N
P
STG
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
D
D
W
S
Q
D
S
N
K
S
D
D
S
R
W
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
G
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
D
G
G
R
L
V
T
F
N
T
N
N
K
H
I
I
G
Y
I
R
N
N
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
A
M
P
F
K
A
H
D
L
I
G
G
K
T
V
S
L
N
Q
D
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
60.33
41%
218
- C6 -
4FLR
5
AMYS_NEIPO
A:
[408-458]
-----------------------------
G
I
S
G
Y
D
H
R
Q
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
Y
N
P
STG
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
D
D
W
S
Q
D
S
N
K
S
D
D
S
R
W
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
D
G
G
R
L
V
T
F
N
T
N
N
K
H
I
I
G
Y
I
R
N
N
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
A
M
P
F
K
A
H
D
L
I
G
G
K
T
V
S
L
N
Q
D
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
59.79
41%
212
- C6 -
1ZS2
2
AMYS_NEIPO
A:
[408-458]
-----------------------------
G
I
S
G
Y
D
H
R
Q
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
Y
N
P
STG
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
D
D
W
S
Q
D
S
N
K
S
D
D
S
R
W
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
G
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
D
G
G
R
L
V
T
F
N
T
N
N
K
H
I
I
G
Y
I
R
N
N
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
A
M
P
F
K
A
H
D
L
I
G
G
K
T
V
S
L
N
Q
D
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
59.73
41%
216
- C6 -
1MW2
2
AMYS_NEIPO
A:
[408-458]
-----------------------------
G
I
S
G
Y
D
H
R
Q
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
Y
N
P
STG
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
D
D
W
S
Q
D
S
N
K
S
D
D
S
R
W
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
D
G
G
R
L
V
T
F
N
T
N
N
K
H
I
I
G
Y
I
R
N
N
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
A
M
P
F
K
A
H
D
L
I
G
G
K
T
V
S
L
N
Q
D
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
59.50
41%
210
- C6 -
1MW0
3
AMYS_NEIPO
A:
[408-458]
-----------------------------
G
I
S
G
Y
D
H
R
Q
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
Y
N
P
STG
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
D
D
W
S
Q
D
S
N
K
S
D
D
S
R
W
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
G
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
D
G
G
R
L
V
T
F
N
T
N
N
K
H
I
I
G
Y
I
R
N
N
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
A
M
P
F
K
A
H
D
L
I
G
G
K
T
V
S
L
N
Q
D
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
59.46
41%
218
- C6 -
1JG9
1
AMYS_NEIPO
A:
[408-458]
-----------------------------
G
I
S
G
Y
D
H
R
Q
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
Y
N
P
STG
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
D
D
W
S
Q
D
S
N
K
S
D
D
S
R
W
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
D
G
G
R
L
V
T
F
N
T
N
N
K
H
I
I
G
Y
I
R
N
N
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
A
M
P
F
K
A
H
D
L
I
G
G
K
T
V
S
L
N
Q
D
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
59.45
41%
225
- C6 -
4FLS
2
AMYS_NEIPO
A:
[408-458]
-----------------------------
G
I
S
G
Y
D
H
R
Q
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
Y
N
P
STG
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
D
D
W
S
Q
D
S
N
K
S
D
D
S
R
W
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
D
G
G
R
L
V
T
F
N
T
N
N
K
H
I
I
G
Y
I
R
N
N
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
A
M
P
F
K
A
H
D
L
I
G
G
K
T
V
S
L
N
Q
D
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
59.24
41%
218
- C6 -
1JGI
1
AMYS_NEIPO
A:
[408-458]
-----------------------------
G
I
S
G
Y
D
H
R
Q
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
Y
N
P
STG
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
D
D
W
S
Q
D
S
N
K
S
D
D
S
R
W
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
D
G
G
R
L
V
T
F
N
T
N
N
K
H
I
I
G
Y
I
R
N
N
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
A
M
P
F
K
A
H
D
L
I
G
G
K
T
V
S
L
N
Q
D
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
59.02
41%
220
- C6 -
4FLQ
2
AMYS_NEIPO
A:
[408-458]
-----------------------------
G
I
S
G
Y
D
H
R
Q
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
Y
N
P
STG
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
D
D
W
S
Q
D
S
N
K
S
D
D
S
R
W
A
H
R
P
R
Y
N
E
A
L
Y
A
Q
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
D
G
G
R
L
V
T
F
N
T
N
N
K
H
I
I
G
Y
I
R
N
N
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
A
M
P
F
K
A
H
D
L
I
G
G
K
T
V
S
L
N
Q
D
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
58.14
26%
-214
- C6 -
2YXQ
-
SECY_METJA
A:
[40-146]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
C
I
D
V
Y
T
A
G
A
Q
I
P
A
I
F
EFW
G
R
I
G
T
------
L
I
T
L
G
I
G
P
-
I
V
T
A
G
I
I
M
Q
L
L
V
G
S
G
I
I
Q
M
D
L
S
I
P
E
N
R
A
L
F
Q
G
C
Q
K
L
L
S
I
I
-
M
C
F
V
E
A
V
L
F
V
G
A
G
A
F
G
I
L
T
P
L
L
A
F
L
V
I
I
Q
I
A
F
G
S
I
I
L
I
Y
L
D
E
I
V
S
K
Y
G
I
G
S
G
I
G
L
F
I
A
A
G
V
S
Q
T
I
F
V
G
A
L
G
P
E
G
Y
L
W
K
F
L
N
S
L
I
Q
G
V
P
N
I
E
Y
I
A
P
I
I
G
T
I
I
V
F
L
M
V
V
Y
A
E
C
M
R
V
E
I
P
L
A
H
G
R
I
K
G
A
V
G
K
Y
P
I
K
F
V
Y
V
S
N
I
P
V
I
L
A
A
A
L
F
A
N
I
Q
L
W
G
L
A
L
Y
R
M
G
I
P
I
L
G
H
Y
E
G
G
R
A
V
D
G
I
A
Y
Y
L
S
T
P
Y
G
L
S
S
V
I
S
D
P
I
H
A
I
V
Y
M
I
A
M
I
I
T
C
V
M
F
G
I
F
W
V
E
T
T
G
L
D
P
K
S
M
A
K
R
I
G
S
L
G
M
A
I
K
G
F
R
K
S
E
K
A
I
E
H
R
L
K
R
Y
I
P
P
L
T
V
M
S
S
18
PsiBlast_PDB
57.88
29%
150
- C4 -
3ECQ
-
GH101_STRR6
A:
[129-202]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
K
-
K
G
L
T
V
D
A
N
G
N
A
T
V
D
L
T
F
K
D
D
S
E
K
G
K
S
R
F
G
V
F
-
L
K
F
K
D
T
K
N
N
V
F
V
G
Y
D
K
D
G
W
F
W
E
Y
K
S
P
T
T
S
T
W
Y
R
G
S
R
V
A
A
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
52.17
8%
227
- C6 -
2W83
2
JIP4_HUMAN
C:
[1-67]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
D
P
E
F
M
G
R
E
V
E
N
L
I
L
E
N
T
Q
L
L
E
T
K
N
A
L
N
I
V
K
N
D
L
I
A
K
V
D
E
L
T
C
E
K
D
V
L
Q
G
E
L
E
A
V
K
Q
A
K
L
K
L
E
E
K
N
--
33
Fugue
49.54
15%
487
- C6 -
4N7V
-
CE152_HUMAN
C:
[15-47]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
E
E
Y
D
E
E
D
Y
E
R
E
K
E
L
Q
Q
L
L
T
D
L
P
H
D
M
L
D
D
D
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------