@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0117: (2016-03-12 )
MNQTILNRVKTRVMHQLVSSLIYENIVVYKASYQDGVGHFTIEGHDSEYRFTAEKTHSFDRIRITSPIERVVGDEADTTTDYTQLLREAVFTFPKNDEKLEQFIVELLQTELKDTQSMQYRESNPPATPETFNDYEFYAMEGHQYHPSYKSRLGFTLSDNLKFGPDFVPNVKLQWLAIDKDKVETTVSRNVVVNEMLRQQVGDKTYEHFVQQIEASGKHVNDVEMIPVHPWQFEHVIQVDLAEERLNGTVLWLGESDELYHPQQSIRTMSPIDTTKYYLKVPISITNTSTKRVLAPHTIENAAQITDWLKQIQQQDMYLKDELKTVFLGEVLGQSYLNTQLSPYKQTQVYGALGVIWRENIYHMLIDEEDAIPFNALYASDKDGLPFIEKWIKQYGSEAWTKQFLAVAIRPMIHMLYYHGIAFESHAQNMMLIHENGWPTRIALKDFHDGVRFKREHLSEAASHLTLKPMPEAHKKVNSNSFIETDDERLVRDFLHDAFFFINIAEIILFIEKQYGIDEQRQWQWVKDIIEAYQEAFPELNNYQHFDLFEPTIQVEKLTTRRLLSDSELRIHHVTNPLGVGGINDATTISET
Atome Classification :
(20 SA)
----------------....------------.....10........20.....---..-------------------.30...-------------------.---....40.----.-----.-..-..-----.50.......--.60.-....-.---.-.70....-------....80........90-...-----..-----------..-..100..-..---...110..------.....120-....-.-..130-----........140..------.....150..---.....160-----....--------....170.......180.......190--........200.......210.--------......220.......----230.......240..--.---..-...250.-.--...----...260..-....----.270..-.-..-..280.-------.-----------..---...290...-...-.300-.......310.---......320.------......330.......340.--....--..350----........360.......------370.......380......---.390...---.--------...--------400.......410--.......420.......430.......440.......450.......460.......470.......480..-..--...490..--.....500.......-----510----.......--------.520-----....-------...530......-.540.-.......550.......560.....--..570.......580-----.........590-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------M
N
Q
T
------------
I
L
N
R
V
K
T
R
V
M
H
Q
L
V
S
S
L
I
YE
N
I
---
V
V
-------------------
Y
K
ASYQ-------------------D---G
V
G
H
F
T
I
----E-----G-HD-S
E
-----
Y
R
F
T
AEKTHS--F
D
R
I
-
R
IT
S
-
P
---
I
-
E
R
V
VGDE-------ADTT
T
D
Y
T
Q
L
L
R
E
A
V
--FTF-----PK-----------
N
D
-
E
K
L
E
Q
F
I
-
V
E
---
L
L
Q
T
E
L
KD------TQSMQYRE-SNPP-A-TPET------FND
Y
E
F
Y
A
MEG
H
Q
------YHP
S
Y
K
SRLG---FTLSDNL------KFGP--------DFVPN
V
K
L
Q
W
L
A
I
D
K
D
K
V
E
T
T
VS
R
N
V
---
V
V
N
E
M
L
R
Q
Q
VG
D
K
T
Y
E
H
F
V
Q
Q
I
--------
E
ASGKHVND
V
E
M
IPVH----PW
Q
F
E
H
V
I
Q
V
D
-
L
A
E
--
E
---RL-N
G
T
V
L
-
W
-L--GES----DELY
H
P
Q
Q
-
S
IRT----MSPIDT-
T
-
K
Y
-
Y
L
K
V
P
I
-------
S
-----------IT---NTST
K
R
V
LA-PHT-IE
N
A
-
A
Q
I
T
D
W
L
K
Q
I
Q
---
Q
Q
D
M
Y
L
K
D
E
L
------
K
T
V
F
L
G
E
V
L
G
Q
S
Y
L
NTQLSP--Y
K
Q
T
--
Q
V
Y
G
-----
A
L
G
V
I
W
R
EN
I
Y
H
M
L
IDEE------DAIPFN
A
L
YASDKDG
L
P
F
I
---
E
K
W
I
K
Q
Y---
G
--------
S
E
A
--------
W
T
K
Q
F
L
A
V
A
I
R
P
M
--
I
H
M
L
Y
YHGIA
F
E
SHAQ
N
M
M
L
I
HENGW
P
T
R
I
A
L
K
D
F
H
D
G
V
R
F
K
R
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H
L
S
E
A
A
SHLTLKPM
P
E
A
H
KKVNSNSFIE-T
D
--
D
E
R
L
V
R
D
F
--
L
H
D
A
F
F
F
I
N
I
A
E
I
I
L
-----
F
I
-----
E
K
QYGI
D
--------
E
Q
R
Q
-----
W
Q
W
V
-------
K
D
I
I
E
A
Y
Q
E
AFP-EL-NN-YQHFDLFEP
T
I
Q
V
E
K
L
T
T
R
RLLSDS--
E
L
R
I
H
HVTNPLGV-------GGINDATTISET-
1
PsiBlast_PDB
99.66
36%
-83
- C5 -
3TO3
2
?
A:
[23-592]
------------------------------------
V
R
R
R
V
L
R
Q
L
V
E
S
L
I
Y
E
G
I
---
I
T
-------------------
P
A
R
I
E
K
-------------------
E
---
E
Q
I
L
F
L
I
----
Q
-----
G
-
L
D
-
E
D
N
K
S
V
T
Y
E
C
Y
G
R
E
R
I
T
--
F
G
R
I
-
S
I
D
S
-
L
---
I
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V
R
V
-
Q
D
G
-------
K
Q
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I
Q
S
V
A
Q
F
L
E
E
V
F
--
R
V
V
-----
N
V
-----------
E
Q
-
T
K
L
D
S
F
I
-
H
E
---
L
E
Q
T
I
F
K
D
------
T
I
A
Q
Y
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R
C
----------
K
S
------
Y
D
E
L
E
N
H
L
I
D
G
H
P
------
Y
H
P
S
Y
K
A
R
I
G
---
F
Q
Y
R
D
N
F
------
R
Y
G
Y
--------
E
F
M
R
P
I
K
L
I
W
I
A
A
H
K
K
N
A
T
V
G
Y
E
N
E
V
---
I
Y
D
K
I
L
K
S
E
V
G
E
R
K
L
E
A
Y
K
E
R
I
--------
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S
M
G
C
D
P
K
Q
Y
L
F
I
P
V
H
----
P
W
Q
W
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N
F
I
I
S
N
-
Y
A
E
--
D
---
I
Q
-
D
K
G
I
I
-
Y
-
L
--
G
E
S
----
A
D
D
Y
C
A
Q
Q
-
S
M
R
T
----
L
R
N
V
T
N
-
P
-
K
R
P
Y
V
K
V
S
L
-------
N
-----------
I
L
---
N
T
S
T
L
R
T
L
K
-
P
Y
S
-
V
A
S
A
-
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A
I
S
N
W
L
S
N
V
V
---
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Q
D
S
Y
L
R
D
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S
------
R
V
I
L
L
K
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F
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S
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M
Y
D
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N
K
K
A
----------
T
Y
G
-----
S
L
G
C
I
W
R
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S
V
H
H
Y
L
G
E
Q
E
------
D
A
V
P
F
N
G
L
Y
A
K
E
K
D
G
T
P
I
I
---
D
A
W
L
N
K
Y
---
G
--------
I
E
N
--------
W
L
R
L
L
I
Q
K
A
I
I
P
V
--
I
H
L
V
V
E
H
G
I
A
L
E
S
H
G
Q
N
M
I
L
V
H
K
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G
L
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A
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G
L
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F
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F
L
K
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M
N
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P
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M
H
K
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Y
A
N
G
K
M
N
D
F
F
E
-
M
D
--
R
I
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C
L
Q
E
M
--
V
L
D
A
L
F
L
F
N
V
G
E
L
A
F
-----
V
L
-----
A
D
K
Y
E
W
K
--------
E
E
S
F
-----
W
M
I
V
-------
V
E
E
I
E
N
H
F
R
K
Y
P
-
H
L
-
K
D
R
F
E
S
I
Q
L
Y
T
P
T
F
Y
A
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Q
L
T
K
R
R
L
Y
I
D
V
--
E
S
L
V
H
E
V
P
N
P
L
----------------------
19
HHSearch
98.68
35%
-75
- C5 -
3TO3
2
?
A:
[16-599]
-----------------
E
S
E
------------
D
Y
I
S
V
R
R
R
V
L
R
Q
L
V
E
S
L
I
Y
E
G
I
---
I
T
-------------------
P
A
R
I
E
K
-------------------
E
---
E
Q
I
L
F
L
I
----
Q
G
L
D
ED
N
-
K
S
-
V
T
-----
Y
E
C
Y
G
R
E
R
I
T
--
F
G
R
I
-
S
I
D
S
-
L
---
I
V
R
V
Q
D
--
G
-------
K
Q
E
I
Q
S
V
A
Q
F
L
E
E
V
F
--
R
V
V
-----
N
V
-----------
E
Q
-
T
K
L
D
S
F
I
-
H
E
---
L
E
Q
T
I
F
K
D
------
T
I
A
Q
Y
E
R
C
----------
K
S
------
Y
D
E
L
E
N
H
L
I
D
G
H
P
------
Y
H
P
S
Y
K
A
R
I
G
---
F
Q
Y
R
D
N
F
------
R
Y
G
Y
--------
E
F
M
R
P
I
K
L
I
W
I
A
A
H
K
K
N
A
T
V
G
Y
E
N
E
V
---
I
Y
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K
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G
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L
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A
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K
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--------
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C
D
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L
F
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----
P
W
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W
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N
F
I
I
S
N
-
Y
A
E
--
D
---
I
Q
-
D
K
G
I
I
-
Y
-
L
--
G
E
S
----
A
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D
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C
A
Q
Q
-
S
M
R
T
----
L
R
N
V
T
N
P
K
-
R
P
-
Y
V
K
V
S
L
-------
N
-----------
I
L
---
N
T
S
T
L
R
T
L
K
-
P
Y
S
-
V
A
S
A
-
P
A
I
S
N
W
L
S
N
V
V
---
S
Q
D
S
Y
L
R
D
E
S
------
R
V
I
L
L
K
E
F
S
S
V
M
Y
D
T
N
K
--------
K
--
A
T
Y
G
-----
S
L
G
C
I
W
R
E
S
V
H
H
Y
L
G
E
Q
E
------
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A
V
P
F
N
G
L
Y
A
K
E
K
D
G
T
P
I
I
---
D
A
W
L
N
K
Y
---
G
--------
I
E
N
--------
W
L
R
L
L
I
Q
K
A
I
I
P
V
--
I
H
L
V
V
E
H
G
I
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I
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L
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C
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D
F
T
K
M
H
K
T
Y
A
N
G
K
M
N
D
F
F
E
-
M
D
--
R
I
E
C
L
Q
E
M
--
V
L
D
A
L
F
L
F
N
V
G
E
L
A
F
-----
V
L
-----
A
D
K
Y
E
W
K
--------
E
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S
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-----
W
M
I
V
-------
V
E
E
I
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N
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F
R
K
Y
P
H
L
K
-
D
R
-
F
E
S
I
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T
P
T
F
Y
A
E
Q
L
T
K
R
R
L
Y
I
D
V
--
E
S
L
V
H
E
V
P
N
P
L
Y
R
-------
A
R
Q
L
N
--------
20
HHSearch
83.28
22%
-68
- C5 -
2X0Q
3
?
A:
[17-606]
-----------------
Q
P
E
------------
I
W
N
K
V
N
R
L
L
V
R
K
A
I
S
E
Y
A
H
E
W
L
---
L
E
-------------------
P
Q
R
L
G
P
-------------------
G
ETP
G
F
E
R
F
R
L
----
T
-----
L
A
D
G
-
A
Q
-----
Y
D
F
D
A
Q
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V
M
A
--
M
R
H
W
-
R
I
P
P
-
E
---
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I
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K
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V
A
G
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P
A
P
L
D
A
L
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F
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I
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I
R
--
D
K
L
-----
G
L
-----------
P
V
-
D
R
L
P
I
Y
M
-
D
E
---
I
T
S
T
L
H
G
S
------
A
Y
K
H
G
R
T
T
L
G
A
A
A
-
L
-
A
R
A
D
------
Y
Q
T
I
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M
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G
H
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------
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F
V
A
N
N
G
R
L
G
---
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D
A
E
D
Y
H
------
G
Y
A
P
--------
E
A
A
T
P
V
R
L
M
W
L
A
V
H
K
D
N
A
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F
S
C
L
S
D
M
---
D
Y
D
S
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E
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A
V
T
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F
A
A
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L
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L
H
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A
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Y
Y
F
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P
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Q
W
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K
L
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L
A
-
F
A
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--
Y
---
V
A
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Q
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K
I
V
-
C
-
L
--
G
Y
G
----
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E
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Y
L
A
Q
Q
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S
I
R
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----
F
F
N
I
S
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P
G
-
K
R
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Y
V
K
T
S
L
-------
S
-----------
I
L
---
N
M
G
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M
R
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-
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Y
Y
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A
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T
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A
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Y
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L
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---
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A
D
P
W
L
R
A
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N
------
G
F
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I
L
R
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V
A
S
M
G
F
R
N
Y
Y
Y
E
A
A
I
D
T
D
T
--
P
Y
K
K
-----
M
F
S
A
L
W
R
E
N
P
L
T
L
I
A
P
G
Q
------
N
L
M
T
M
A
A
L
L
H
V
D
P
Q
G
R
A
L
L
---
P
E
L
I
Q
A
S
---
G
LD------
A
G
T
--------
W
L
E
R
Y
V
D
A
Y
L
T
P
L
--
I
H
C
F
Y
A
H
D
L
V
F
M
P
H
G
E
N
V
I
L
V
I
Q
D
G
V
P
V
R
A
F
M
K
D
I
A
E
E
S
S
I
L
N
P
Q
V
R
L
----------
P
Q
A
A
Q
R
-----
L
---
A
A
--
D
V
P
E
A
Y
K
L
LT
I
F
V
D
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F
E
G
Y
F
R
H
L
T
Q
-----
I
L
-----
V
E
T
E
L
M
P
--------
E
H
D
F
-----
W
R
L
V
-------
A
G
R
I
A
A
Y
Q
Q
A
H
P
Q
R
L
-
D
K
-
Y
R
R
Y
D
L
F
A
P
D
M
I
H
S
C
L
N
R
L
Q
L
A
N
--------
P
N
L
P
N
P
I
A
C
-------
F
R
P
S
W
L
-------
29
Fugue
82.42
21%
-65
* C5 *
2X0O
5
?
A:
[7-601]
-------PH
P
A
E
I
V
A
H
L
Q
P
E
------------
I
W
N
K
V
N
R
L
L
V
R
K
A
I
S
E
Y
A
H
E
W
L
L
E
P
Q
R
-------------------
L
G
P
G
E
T
-------------------
P
---
G
F
E
R
F
R
L
----
T
L
----
A
-
D
G
-
A
Q
-----
Y
D
F
D
A
Q
V
M
-
A
--
M
R
H
W
-
R
I
P
P
-
E
---
S
-
I
V
K
T
V
A
G
-------
V
P
A
P
L
D
A
L
Q
F
V
I
E
I
R
--
D
K
L
-----
G
L
-----------
P
V
-
D
R
L
P
I
Y
M
-
D
E
---
I
T
S
T
L
H
G
S
------
A
Y
K
H
G
R
T
T
-
L
G
A
A
-
A
L
A
R
A
D
------
Y
Q
T
I
E
T
S
M
I
E
G
H
P
------
S
F
V
A
N
N
G
R
L
G
---
F
D
A
E
D
Y
H
------
G
Y
A
P
--------
E
A
A
T
P
V
R
L
M
W
L
A
V
H
K
D
N
A
H
F
S
C
L
S
D
M
---
D
Y
D
S
L
M
S
E
E
L
G
E
S
A
V
T
D
F
A
A
R
L
--------
R
E
Q
G
L
H
P
A
D
Y
Y
F
M
P
A
H
----
P
W
Q
W
F
N
K
L
S
L
A
-
F
A
P
--
Y
---
V
A
-
Q
R
K
I
V
-
C
-
L
--
G
Y
G
----
E
E
Q
Y
L
A
Q
Q
-
S
I
R
T
----
F
F
N
I
S
R
-
P
G
K
R
-
Y
V
K
T
S
L
-------
S
-----------
I
L
---
N
M
G
F
M
R
G
L
S
-
P
Y
Y
-
M
A
G
T
-
P
A
I
N
E
Y
I
H
D
L
I
---
S
A
D
P
W
L
R
A
N
-------
G
F
R
I
L
R
E
V
A
S
M
G
F
R
N
Y
Y
Y
E
A
--
A
I
D
T
DT
P
Y
K
K
-----
M
F
S
A
L
W
R
E
N
P
L
T
L
I
A
P
G
Q
------
N
L
M
T
M
A
A
L
L
H
V
D
P
Q
G
R
A
L
L
---
P
E
L
I
Q
A
S
---
G
LD------
A
G
T
--------
W
L
E
R
Y
V
D
A
Y
L
T
P
L
--
I
H
C
F
Y
A
H
D
L
V
F
M
P
H
G
E
N
V
I
L
V
I
Q
D
G
V
P
V
R
A
F
M
K
D
I
A
E
E
S
S
I
L
N
P
Q
----------
V
R
L
P
Q
A
A
Q
R
L
-----
A
A
-
D
V
--
P
E
A
Y
K
L
L
T
--
I
F
V
D
V
F
E
G
Y
F
R
H
L
T
Q
-----
I
L
-----
V
E
T
E
L
M
P
--------
E
H
D
F
-----
W
R
L
V
-------
A
G
R
I
A
A
Y
Q
Q
A
H
P
-
Q
R
L
D
K
-
Y
R
R
Y
D
L
F
A
P
D
M
------
I
H
S
C
L
N
R
L
--
Q
L
A
A
P
N
L
P
N
P
I
A
C
-------
F
------------
21
HHSearch
77.07
18%
-55
- C5 -
2X3J
6
?
A:
[8-588]
------------------
V
L
------------
S
R
M
I
S
E
K
A
A
L
H
G
L
L
N
C
L
I
K
E
F
A
---
I
P
-------------------
E
G
Y
L
R
Y
EWPDEMKGIPPGAYFDGAD
W
---
K
G
I
P
M
M
I
----
G
-----
L
-
P
D
Q
L
Q
-----
L
F
V
M
V
D
R
R
D
T
--
F
G
S
Q
-
H
Y
L
S
-
D
---
V
Y
L
R
Q
A
Q
G
--------
D
W
Q
C
P
D
F
E
P
L
V
A
R
L
L
--
A
A
C
-----
E
H
I
----------
A
G
-
R
K
N
P
E
L
Y
-
E
Q
---
I
L
Q
S
Q
R
L
V
------
S
A
I
V
S
H
N
G
R
Q
R
A
D
-
A
-
P
L
Q
H
------
Y
L
Q
S
E
Q
G
L
W
F
G
H
P
------
S
H
P
A
P
K
A
R
L
W
---
P
A
H
L
G
Q
E
------
Q
W
A
P
--------
E
F
Q
A
R
A
A
L
H
Q
F
E
V
P
V
D
G
L
H
I
G
A
N
G
-
L
---
T
P
Q
Q
V
L
D
G
-------------
F
--------
A
D
Q
Q
P
A
S
P
G
H
A
I
I
C
M
H
----
P
V
Q
A
Q
L
F
M
Q
D
A
R
V
Q
Q
--
L
---
L
R
-
D
N
V
I
R
-
D
-
L
--
G
Q
S
----
G
R
V
A
S
P
T
A
-
S
I
R
T
----
W
F
I
D
D
--
H
-
D
Y
-
F
I
K
G
S
L
-------
N
-----------
V
R
---
I
T
N
C
V
R
K
N
A
-
W
Y
E
-
L
E
S
T
-
V
L
I
D
R
L
F
R
Q
L
L
---
D
Q
H
A
D
T
L
--
G
------
G
L
V
A
A
A
E
P
G
V
V
S
W
S
P
A
A
A
G
E
--
L
D
S
H
--
W
F
R
E
-----
Q
T
G
G
I
L
R
E
N
F
C
R
R
T
-
G
A
E
------
R
S
I
M
A
G
T
L
F
A
R
G
V
D
L
Q
P
M
I
---
Q
T
F
L
R
T
H
Y
--
G
EALD
D
N
A
-
L
L
Y
--------
W
F
D
D
Y
Q
T
R
L
L
R
P
V
--
L
S
L
F
F
N
H
G
V
V
M
E
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
F
E
-
G
V
K
L
T
D
D
L
G
I
R
Y
I
-
D
D
---
D
I
H
P
R
----
V
R
Q
S
L
---
L
Y
--
S
R
E
Q
G
W
N
R
--
I
M
Y
C
L
F
I
N
H
L
S
E
T
I
L
-----
A
L
-----
S
Q
G
R
P
Q
L
--------
A
P
L
M
-----
W
R
R
V
-------
Q
Q
Q
L
R
A
I
Q
G
E
L
K
-
Q
P
-
S
P
-
E
L
D
A
L
I
A
G
H
P
V
A
C
K
T
N
L
K
V
R
L
A
A
E
A
DR
Q
A
S
Y
V
R
L
P
S
P
W
G
---------------------
30
Fugue
74.44
17%
-49
- C5 -
2W02
2
?
A:
[5-587]
---------------N
H
D
V
L
------------
S
R
M
I
S
E
K
A
A
L
H
G
L
L
N
C
L
I
K
E
F
A
---
I
P
EGYLRYEWPDEMKGIPPGA
Y
F
D
G
A
D
-------------------
W
---
K
G
I
P
M
M
I
----
G
L
----
P
-
D
Q
-
L
Q
-----
L
F
V
M
V
D
R
R
D
T
--
F
G
S
Q
-
H
Y
L
S
-
D
---
V
-
Y
L
R
Q
A
G
D
-------
W
-
Q
C
P
D
F
E
P
L
V
A
R
L
L
--
A
A
C
-----
E
H
-----------
I
A
G
R
K
N
P
E
L
Y
-
E
Q
---
I
L
Q
S
Q
R
L
V
------
S
A
I
V
S
H
N
G
-
R
Q
R
A
D
A
-
P
L
Q
H
------
Y
L
Q
S
E
Q
G
L
W
F
G
H
P
------
S
H
P
A
P
K
A
R
L
W
---
P
A
-
L
G
Q
E
------
Q
W
A
P
--------
E
F
Q
A
R
A
A
L
H
Q
F
E
V
P
-----------------
V
D
G
L
H
I
G
A
N
G
L
T
P
Q
Q
V
L
D
G
F
--------
A
D
Q
Q
P
A
S
P
G
H
A
I
I
C
M
H
----
P
V
Q
A
Q
L
F
M
Q
D
A
-
R
V
Q
--
Q
---
L
L
R
D
N
V
I
R
-
D
-
L
--
G
Q
S
----
G
R
V
A
S
P
T
A
-
S
I
R
T
----
W
F
I
D
D
H
---
D
Y
-
F
I
K
G
S
L
-------
N
-----------
V
R
---
I
T
N
C
V
R
K
N
A
-
W
Y
E
-
L
E
S
T
-
V
L
I
D
R
L
F
R
Q
L
L
---
D
Q
H
A
D
T
L
G
G
L
------
V
--
A
A
A
E
P
G
V
V
S
W
S
P
A
A
A
G
E
--
L
D
S
H
--
W
F
R
E
-----
Q
T
G
G
I
L
R
E
N
F
C
R
R
T
-
G
A
E
------
R
S
I
M
A
G
T
L
F
A
R
G
V
D
L
Q
P
M
I
---
Q
T
F
L
R
T
H
---
Y
GEALD
D
N
A
L
L
Y
--------
W
F
D
D
Y
Q
T
R
L
L
R
P
V
--
L
S
L
F
F
N
H
G
V
V
M
E
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
F
-
E
G
V
K
L
T
D
D
L
G
I
R
Y
I
D
D
D
I
H
P
R
V
R
Q
S
L
-----------
L
Y
--
S
R
E
Q
G
W
N
R
--
I
M
Y
C
L
F
I
N
H
L
S
E
T
I
L
-----
A
L
-----
S
Q
G
R
P
Q
L
--------
A
P
L
M
-----
W
R
R
V
-------
Q
Q
Q
L
R
A
I
Q
G
E
L
K
-
Q
P
-
S
P
-
E
L
D
A
L
I
A
G
H
P
V
A
C
K
T
N
L
K
V
R
L
A
A
------
S
Y
V
R
L
P
S
P
W
----------------------
2
PsiBlast_PDB
63.48
25%
-66
- C5 -
2W02
2
?
A:
[169-476]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
P
------
S
H
P
A
P
K
A
R
L
W
---
P
A
-
L
G
Q
E
------
Q
W
A
P
--------
E
F
Q
A
R
A
A
L
H
Q
F
E
V
P
V
D
G
L
------
H
I
---
G
A
N
G
L
T
P
Q
Q
V
L
D
G
----
F
A
D
Q
Q
--------
P
A
S
P
G
H
A
----
I
I
C
M
H
----
P
V
Q
A
Q
L
F
M
Q
D
A
-
R
V
Q
--
Q
---
L
L
-
R
D
N
V
I
-
R
D
L
--
G
Q
S
----
G
R
V
A
S
P
T
A
-
S
I
R
T
----
W
F
-
I
D
D
-
H
-
D
Y
-
F
I
K
G
S
L
-------
N
-----------
V
R
---
I
T
N
C
V
R
K
N
A
-
W
Y
E
-
L
E
S
T
-
V
L
I
D
R
L
F
R
Q
----------
L
L
D
Q
H
------
A
D
T
L
G
G
L
V
A
A
A
E
P
G
V
V
S
W
S
P
--
A
A
A
G
--
E
L
D
S
H
W
F
R
E
Q
T
G
G
I
L
R
E
N
-
F
C
R
R
T
G
A
E
------
R
S
I
M
A
G
T
L
F
A
R
G
V
D
L
Q
P
M
I
---
Q
T
F
L
R
T
H
---
Y
--------
G
E
A
LD
D
N
A
L
L
Y
W
F
D
D
Y
Q
T
R
L
L
R
P
V
--
L
S
L
F
F
N
H
G
V
V
M
E
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
F
-
E
G
V
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.26
25%
-65
- C5 -
2X3K
2
?
A:
[169-475]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
P
------
S
H
P
A
P
K
A
R
L
W
---
P
A
H
L
G
Q
E
------
Q
W
A
P
--------
E
F
Q
A
R
A
A
L
H
Q
F
E
V
P
V
D
G
L
------
H
I
---
G
A
N
G
L
T
P
Q
Q
V
L
D
G
----
F
A
D
Q
Q
--------
P
A
S
P
G
H
A
----
I
I
C
M
H
----
P
V
Q
A
Q
L
F
M
Q
D
A
-
R
V
Q
--
Q
---
L
L
-
R
D
N
V
I
-
R
D
L
--
G
Q
S
----
G
R
V
A
S
P
T
A
-
S
I
R
T
----
W
F
-
I
D
D
-
H
-
D
Y
-
F
I
K
G
S
L
-------
N
-----------
V
R
---
I
T
N
C
V
R
K
N
A
-
W
Y
E
-
L
E
S
T
-
V
L
I
D
R
L
F
R
Q
----------
L
L
D
Q
H
------
A
D
T
L
G
G
L
V
A
A
A
E
P
G
V
V
S
W
S
P
--
A
A
A
G
--
E
L
D
S
H
W
F
R
E
Q
T
G
G
I
L
R
E
N
-
F
C
R
R
T
G
A
E
------
R
S
I
M
A
G
T
L
F
A
R
G
V
D
L
Q
P
M
I
---
Q
T
F
L
R
T
H
---
Y
--------
G
E
A
LD
D
N
A
L
L
Y
W
F
D
D
Y
Q
T
R
L
L
R
P
V
--
L
S
L
F
F
N
H
G
V
V
M
E
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
F
-
E
G
V
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.76
25%
-67
- C5 -
2X3J
4
?
A:
[169-470]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
P
------
S
H
P
A
P
K
A
R
L
W
---
P
A
H
L
G
Q
E
------
Q
W
A
P
--------
E
F
Q
A
R
A
A
L
H
Q
F
E
V
P
V
D
G
L
------
H
I
---
G
A
N
G
L
T
P
Q
Q
V
L
D
G
----
F
A
D
Q
Q
--------
P
A
S
P
G
H
A
----
I
I
C
M
H
----
P
V
Q
A
Q
L
F
M
Q
D
A
-
R
V
Q
--
Q
---
L
L
-
R
D
N
V
I
-
R
D
L
--
G
Q
S
----
G
R
V
A
S
P
T
A
-
S
I
R
T
----
W
F
-
I
D
D
-
H
-
D
Y
-
F
I
K
G
S
L
-------
N
-----------
V
R
---
I
T
N
C
V
R
K
N
A
-
W
Y
E
-
L
E
S
T
-
V
L
I
D
R
L
F
R
Q
----------
L
L
D
Q
H
------
A
D
T
L
G
G
L
V
A
A
A
E
P
G
V
V
S
W
S
P
--
A
A
A
G
--
E
L
D
S
H
W
F
R
E
Q
T
G
G
I
L
R
E
N
-
F
C
R
R
T
G
A
E
------
R
S
I
M
A
G
T
L
F
A
R
G
V
D
L
Q
P
M
I
---
Q
T
F
L
R
T
H
---
Y
--------
G
E
A
LD
D
N
A
L
L
Y
W
F
D
D
Y
Q
T
R
L
L
R
P
V
--
L
S
L
F
F
N
H
G
V
V
M
E
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
F
-
E
G
V
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
62.64
25%
-70
- C5 -
3FFE
-
?
A:
[169-476]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
P
------
S
H
P
A
P
K
A
R
L
W
---
P
A
H
L
G
Q
E
------
Q
W
A
P
--------
E
F
Q
A
R
A
A
L
H
Q
F
E
V
P
V
D
G
L
------
H
I
---
G
A
N
G
L
T
P
Q
Q
V
L
D
G
----
F
A
D
Q
Q
--------
P
A
S
P
G
H
A
----
I
I
C
M
H
----
P
V
Q
A
Q
L
F
M
Q
D
A
-
R
V
Q
--
Q
---
L
L
-
R
D
N
V
I
-
R
D
L
--
G
Q
S
----
G
R
V
A
S
P
T
A
-
S
I
R
T
----
W
F
-
I
D
D
-
H
-
D
Y
-
F
I
K
G
S
L
-------
N
-----------
V
R
---
I
T
N
C
V
R
K
N
A
-
W
Y
E
-
L
E
S
T
-
V
L
I
D
R
L
F
R
Q
----------
L
L
D
Q
H
------
A
D
T
L
G
G
L
V
A
A
A
E
P
G
V
V
S
W
S
P
--
A
A
A
G
--
E
L
D
S
H
W
F
R
E
Q
T
G
G
I
L
R
E
N
-
F
C
R
R
T
G
A
E
------
R
S
I
M
A
G
T
L
F
A
R
G
V
D
L
Q
P
M
I
---
Q
T
F
L
R
T
H
---
Y
--------
G
E
A
LD
D
N
A
L
L
Y
W
F
D
D
Y
Q
T
R
L
L
R
P
V
--
L
S
L
F
F
N
H
G
V
V
M
E
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
F
-
E
G
V
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
62.10
25%
-64
- C5 -
2W03
2
?
A:
[169-476]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
P
------
S
H
P
A
P
K
A
R
L
W
---
P
A
H
L
G
Q
E
------
Q
W
A
P
--------
E
F
Q
A
R
A
A
L
H
Q
F
E
V
P
V
D
G
L
------
H
I
---
G
A
N
G
L
T
P
Q
Q
V
L
D
G
----
F
A
D
Q
Q
--------
P
A
S
P
G
H
A
----
I
I
C
M
H
----
P
V
Q
A
Q
L
F
M
Q
D
A
-
R
V
Q
--
Q
---
L
L
-
R
D
N
V
I
-
R
D
L
--
G
Q
S
----
G
R
V
A
S
P
T
A
-
S
I
R
T
----
W
F
-
I
D
D
-
H
-
D
Y
-
F
I
K
G
S
L
-------
N
-----------
V
R
---
I
T
N
C
V
R
K
N
A
-
W
Y
E
-
L
E
S
T
-
V
L
I
D
R
L
F
R
Q
----------
L
L
D
Q
H
------
A
D
T
L
G
G
L
V
A
A
A
E
P
G
V
V
S
W
S
P
--
A
A
A
G
--
E
L
D
S
H
W
F
R
E
Q
T
G
G
I
L
R
E
N
-
F
C
R
R
T
G
A
E
------
R
S
I
M
A
G
T
L
F
A
R
G
V
D
L
Q
P
M
I
---
Q
T
F
L
R
T
H
---
Y
--------
G
E
A
LD
D
N
A
L
L
Y
W
F
D
D
Y
Q
T
R
L
L
R
P
V
--
L
S
L
F
F
N
H
G
V
V
M
E
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
F
-
E
G
V
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
61.43
25%
-67
- C5 -
2W04
-
?
A:
[169-476]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
P
------
S
H
P
A
P
K
A
R
L
W
---
P
A
H
L
G
Q
E
------
Q
W
A
P
--------
E
F
Q
A
R
A
A
L
H
Q
F
E
V
P
V
D
G
L
------
H
I
---
G
A
N
G
L
T
P
Q
Q
V
L
D
G
----
F
A
D
Q
Q
--------
P
A
S
P
G
H
A
----
I
I
C
M
H
----
P
V
Q
A
Q
L
F
M
Q
D
A
-
R
V
Q
--
Q
---
L
L
-
R
D
N
V
I
-
R
D
L
--
G
Q
S
----
G
R
V
A
S
P
T
A
-
S
I
R
T
----
W
F
-
I
D
D
-
H
-
D
Y
-
F
I
K
G
S
L
-------
N
-----------
V
R
---
I
T
N
C
V
R
K
N
A
-
W
Y
E
-
L
E
S
T
-
V
L
I
D
R
L
F
R
Q
----------
L
L
D
Q
H
------
A
D
T
L
G
G
L
V
A
A
A
E
P
G
V
V
S
W
S
P
--
A
A
A
G
--
E
L
D
S
H
W
F
R
E
Q
T
G
G
I
L
R
E
N
-
F
C
R
R
T
G
A
E
------
R
S
I
M
A
G
T
L
F
A
R
G
V
D
L
Q
P
M
I
---
Q
T
F
L
R
T
H
---
Y
--------
G
E
A
LD
D
N
A
L
L
Y
W
F
D
D
Y
Q
T
R
L
L
R
P
V
--
L
S
L
F
F
N
H
G
V
V
M
E
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
F
-
E
G
V
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
55.10
20%
-40
- C3 -
4NOM
-
LGMN_MOUSE
A:
[26-432]
-----------------------------------------------------------------------------------
E
-------------------
D
---
G
G
K
H
W
V
V
I
V
A
G
S
-----
N
-
G
W
-
Y
N
-----
Y
R
H
Q
A
D
A
C
H
A
--
Y
Q
I
I
-
H
R
N
G
------------------------------
I
P
D
E
Q
I
--
I
V
M
-----
M
Y
-----------
D
D
-------------------------------
I
A
N
S
E
-
E
N
P
T
-------------------------------------------------------------
P
--------
G
V
V
I
N
R
P
N
----------
G
T
D
V
Y
K
G
V
---
L
------------------------------------
K
D
Y
T
G
E
D
V
T
----
P
E
N
F
L
A
V
L
R
G
D
-
A
E
A
VK
G
---
K
G
-
S
G
K
V
L
-
K
-
S
--
G
P
R
----
D
------------------------------
H
V
F
I
-------
Y
-----------
F
T
---
D
H
G
A
T
G
I
L
V
F
P
N
D
-
D
L
H
V
-
K
D
L
N
K
T
I
R
Y
M
Y
---
E
H
K
M
Y
Q
----------
K
M
V
F
Y
I
E
A
C
E
S
G
S
M
M
N
H
L
P
D
----
D
I
--
N
V
Y
A
-----
T
T
A
A
N
P
K
E
S
S
Y
A
C
Y
Y
D
E
E
RGTYLG
D
W
Y
S
V
N
W
M
E
D
S
D
V
E
D
L
T
------------------------
K
E
T
--------
L
H
K
Q
Y
H
L
V
K
S
H
T
N
--
T
S
H
V
M
Q
Y
G
N
K
S
I
S
T
M
K
V
M
Q
F
Q
G
M
K
H
R
A
S
S
--------------
P
I
S
L
P
P
V
T
H
L
D
L
T
P
S
P
D
V
P
L
T
I
L
K
R
K
L
L
R
-
T
N
--
D
V
K
E
S
Q
N
L
--
I
G
Q
I
Q
Q
F
L
D
A
R
H
V
I
E
K
S
V
H
K
I
V
-----
S
L
L
A
G
F
G
--------
E
T
A
E
-----
R
H
L
S
-------
E
R
T
M
L
T
A
H
D
C
Y
Q
-
E
A
----
V
T
H
F
R
T
H
C
F
N
W
H
--
S
V
T
Y
E
H
A
L
R
Y
L
--
Y
V
L
A
N
L
C
E
A
P
Y
P
I
-------
D
R
I
E
M
A
M
D
K
V
C
L
-
37
Fugue
54.00
15%
-24
- C3 -
4Y9J
4
?
A:
[1-592]
TITARHTQYSHAKTGG
F
S
Q
T
G
P
TLHNPYKDDP
I
L
D
R
T
L
R
R
L
L
P
E
S
E
Y
M
R
V
A
A
D
L
---
S
K
-------------------
F
G
D
R
I
T
-------------------
S
---
E
V
E
H
L
G
R
----
Q
-----
A
-
E
L
-
E
Q
-----
P
R
L
E
H
Q
D
A
W
G
KR
V
D
K
L
-
I
V
C
N
-
E
W
H
K
L
-
K
Q
I
C
A
E
E
GV
I
S
I
G
Y
E
D
S
V
D
P
F
V
R
R
I
H
Q
V
A
K
L
F
L
F
-----
S
P
SAGLV
S
C
P
M
A
M
T
D
-
G
A
V
K
T
L
T
S
L
N
---
L
Y
G
K
H
K
L
A
------
T
E
A
V
D
R
L
R
-
S
R
D
P
-
S
-
K
A
W
T
------
S
G
Q
W
M
T
E
K
K
G
G
S
D
------
V
A
G
G
C
D
T
Y
A
V
---
Q
I
D
K
D
T
Y
------
R
L
H
-------------
G
Y
K
W
F
S
S
A
V
D
A
D
-
V
A
L
T
L
A
R
I
V
-----
D
S
D
G
N
A
L
E
G
S
R
G
L
S
L
F
L
L
K
I
--------
R
D
E
S
G
N
L
N
G
I
Q
M
V
R
L
K
----
N
--
K
L
G
T
K
Q
L
P
-
T
A
E
--
L
---
L
L
-
D
G
A
I
A
E
R
-
I
--
G
D
Q
GR
G
V
A
G
I
S
N
M
L
N
-
I
T
R
I
----
H
N
A
V
A
S
-
L
-
G
Y
-
M
R
R
I
I
S
-------
L
-----------
A
R
---
D
Y
S
T
K
R
V
V
F
-
G
Q
T
-
Q
S
K
W
-
P
L
H
T
T
T
L
A
K
M
E
V
D
T
R
G
S
M
L
L
L
F
E
A
------
A
R
L
L
G
L
S
E
A
G
K
S
---
S
D
V
E
A
--
M
M
L
R
--
L
I
T
P
-----
V
L
K
L
Y
A
G
K
Q
A
V
P
M
V
S
E
G
I
------
E
C
F
--
G
G
Q
G
Y
M
E
D
T
G
L
P
T
L
---
L
R
D
A
Q
V
T
---
P
--------
I
W
E
--------
G
T
T
N
V
L
S
L
D
V
L
R
V
--
F
S
G
K
E
N
I
L
L
A
F
G
K
R
V
E
Q
L
L
--------
G
N
T
K
T
E
D
-------
E
K
L
K
K
S
K
E
A
V
E
S
A
L
K
Q
L
Q
K
L
L
V
K
A
S
D
S
A
I
Q
G
E
T
R
--
I
D
S
V
A
R
H
I
--
A
F
T
I
A
R
I
Y
S
G
A
L
L
I
D
-----
H
A
-----
S
D
S
S
V
A
N
--------------------
Q
-------
S
D
I
E
V
A
Y
R
Y
C
C
E
-
Q
P
-
L
----------
I
D
L
R
W
E
W
F
A
S
E
R
V
K
A
D
R
--
E
I
V
F
D
N
F
T
-------------------------
32
Fugue
52.63
17%
-19
- C2 -
3WKX
2
HYBA1_BIFL2
A:
[1-659]
----------------
M
N
V
T
------------
I
T
S
P
F
W
K
R
R
R
D
Q
I
V
E
S
V
I
P
Y
Q
W
---
G
V
-------------------
M
N
D
E
I
D
-------------------
T
--------
T
V
----
P
-----
D
-
D
P
-
A
G
-----
N
Q
L
A
D
S
K
S
H
A
--
V
A
N
L
-
K
V
A
A
G
E
---
L
-
D
D
E
F
H
G
M
-------
V
F
Q
D
S
D
V
Y
K
W
L
E
E
A
A
--
Y
A
L
A
Y
HPD
P
E
-----------
L
K
-
A
L
C
D
R
T
V
-
D
L
---
I
A
R
A
Q
Q
S
D
GYLD
T
P
Y
Q
I
K
S
G
V
W
-
A
D
R
P
-
R
-
F
S
L
I
------
Q
Q
S
H
E
M
Y
V
M
-
G
H
Y
I
E
A
A
V
A
Y
H
Q
V
T
G
N
E
Q
A
---
L
E
V
A
K
K
M
A
D
C
L
D
A
N
F
G
P
EEGKIHGA
D
G
H
P
E
I
E
L
A
L
A
K
L
Y
E
E
T
G
E
---
K
R
Y
L
---
T
L
S
Q
Y
L
I
D
V
R
G
Q
D
P
Q
F
Y
A
K
Q
L
K
--------
A
M
N
G
D
N
I
F
H
G
F
Y
K
P
T
Y
----
F
Q
A
A
E
P
V
R
D
Q
Q
-
T
A
D
--
G
H
A
V
R
V
-
G
Y
L
C
T
-
G
-
V
--
A
H
V
----
G
R
L
L
G
D
Q
G
-
L
I
D
T
A
K
R
F
W
K
N
I
V
T
-
R
-
R
M
-
Y
V
T
G
A
I
GSTHVGE
S
-----------
F
T
YDY
D
L
P
N
D
T
M
Y
G
-
E
T
C
-
A
S
V
A
M
S
M
F
A
Q
Q
M
L
D
L
E
---
P
K
G
E
Y
A
D
V
L
E
------
K
E
L
F
N
G
S
I
A
G
I
S
-
L
D
G
K
Q
Y
Y
--
Y
V
N
A
--
L
E
T
T
-----
P
D
G
L
D
N
P
D
R
-
H
H
V
L
S
H
R
V
------
D
W
F
G
C
A
C
C
P
A
N
I
A
R
L
I
A
S
V
---
D
R
Y
I
Y
T
E
R
DG
G
--------
K
T
V
--------
L
S
H
Q
F
I
A
N
T
A
E
F
A
SG
L
T
V
E
Q
R
S
N
F
P
W
D
G
H
V
E
Y
T
V
S
L
-----
P
A
S
A
T
D
S
S
V
R
F
G
L
R
I
P
--
G
W
S
R
G
S
Y
T
L
T
V
N
G
K
P
A
V
G
S
L
E
D
G
F
V
Y
L
V
-
V
N
AG
D
T
L
E
I
A
L
E
--
L
D
M
S
V
K
F
V
R
A
N
S
R
V
R
-----
S
D
-----
A
G
Q
V
A
V
M
R
GP
L
V
Y
C
A
E
Q
V
D
NPGDL
W
N
Y
R
L
A
D
GVTG
A
D
A
A
V
A
F
Q
A
--
D
-
L
L
-
G
G
-
V
D
T
V
D
L
P
A
V
R
E
H
A
D
E
D
D
A
P
L
Y
V
D
A
D
--
E
P
R
A
G
E
P
A
T
L
R
L
V
PYYSWAN
R
E
I
G
E
M
R
V
F
Q
R
R
A
36
Fugue
52.39
16%
-28
* C3 *
4XGC
-
?
C:
[1-676]
---MQ
P
F
Y
E
E
Y
R
K
A
W
N
Q
I
N
D
------------
H
I
A
D
L
Q
H
R
S
Y
A
R
T
L
E
Q
L
V
--
D
F
---
V
V
-------------------
G
Q
A
E
R
D
-------------------
E
---
V
L
P
T
A
A
L
----
L
-----
T
-
G
I
-
N
Q
-----
P
D
H
L
S
Q
F
T
A
L
--
T
Q
R
L
-
H
A
Q
R
-
A
---
A
-
M
V
C
V
L
Q
S
-------
R
D
C
A
T
-
L
K
A
A
V
E
T
L
V
--
F
G
L
-----
V
E
-----------
D
N
-
A
E
V
E
Q
--------
L
R
R
S
Q
C
T
M
------
K
Q
L
K
S
W
Y
T
-
N
N
F
D
-
S
-
E
Q
K
R
R
Q
L
V
V
I
L
P
D
F
E
C
F
-------------
N
A
S
V
L
Q
D
L
I
---
L
I
L
S
A
H
C
------------------
G
S
L
P
F
V
L
V
L
G
V
A
T
A
M
T
A
V
H
G
T
L
P
Y
H
V
S
S
K
I
R
L
R
V
F
Q
T
Q
A
A
P
T
G
L
N
E
V
L
D
K
V
LLSPKYA
F
H
L
S
G
K
T
F
K
F
L
T
H
I
F
L
Y
YDFS
I
H
G
F
I
Q
G
F
K
Y
C
-
L
M
E
--
H
---
F
F
-
G
G
N
A
F
-
A
-
L
CT
D
Y
S
----
K
A
L
G
R
I
K
Q
L
T
H
E
D
----
M
E
T
I
R
R
-
L
-
P
S
-
F
R
P
Y
V
E
-------
Q
-----------
I
N
---
D
C
K
R
I
I
A
V
L
-
T
D
D
-
D
Y
L
K
-
K
K
L
P
Q
L
L
R
D
C
L
---
L
H
F
L
L
F
R
C
S
L
------
E
--
F
L
T
E
L
V
G
-
D
L
P
R
C
P
L
G
K
--
L
--------------------
R
R
E
L
Y
V
N
C
L
N
R
--------
A
I
I
S
T
P
E
Y
K
E
C
L
Q
M
L
S
F
L
SK
D
E
F
V
A
K
V
N
---
R
--------
A
L
E
--------
R
T
E
Q
F
L
V
E
E
I
A
P
L
------------------------
E
L
G
E
A
C
T
A
V
L
R
P
K
L
E
A
I
R
L
A
V
D
E
V
G
--------
R
A
L
Q
K
T
L
Q
L
I
E
T
Q
--
I
V
-
Q
D
--
H
L
R
A
L
Q
D
A
PP
I
H
E
L
F
V
F
S
D
I
A
T
V
R
R
-----
N
I
I
GAP
R
A
A
L
H
T
A
L
--------
N
N
P
H
-----
F
P
D
L
-------
S
V
V
Y
K
L
H
L
E
C
G
R
-
M
I
-
N
L
-
F
D
W
L
Q
A
F
R
S
V
V
P
Q
I
Q
A
R
F
T
R
A
V
A
E
L
--
Q
F
L
G
Y
I
K
M
S
K
R
K
T
-------
D
H
A
T
R
L
T
W
-----
33
Fugue
50.27
21%
-23
* C6 *
3ACP
-
RPN14_YEAST
A:
[1-417]
----------------
M
T
K
T
------------
I
--------------------------------------------------------------------------
T
V
A
H
I
------------------
Q
-----
Y
D
F
K
A
V
L
------------------------------------------------------------
E
E
-----------
N
D
-
E
N
D
D
E
F
Y
-
I
N
---
V
D
K
-
N
L
N
E
------
I
K
E
H
K
I
V
V
-
L
G
N
S
-
R
-
G
V
D
A
------
G
K
G
N
T
F
E
K
V
G
S
H
----------
L
Y
K
A
R
L
D
G
H
D
F
L
F
N
T
I
I
------
R
D
G
S
--------
K
M
L
K
R
A
D
--
Y
T
A
V
D
T
A
K
L
Q
--
M
R
R
F
I
---
L
G
T
T
E
G
D
I
K
V
L
D
---
S
N
F
N
L
Q
R
--------
E
I
D
Q
A
H
V
S
E
I
T
K
L
K
F
F
----
P
-
S
G
E
A
L
I
S
S
S
-
Q
D
M
--
Q
---
L
K
-
I
W
S
V
K
-
D
-
G
--
S
N
P
----
R
T
L
I
G
H
R
A
-
T
V
T
D
----
I
A
I
I
D
R
-
G
-
R
N
-
V
L
S
A
S
L
-------
D
GTI
R
L
W
E
CGTG
T
T
---
I
H
T
F
N
R
K
E
N
-
P
H
D
G
V
N
S
I
-
A
L
F
V
G
T
D
R
Q
L
H
---
E
I
S
T
S
K
K
N
N
L
EFGTYG
K
Y
V
I
A
G
H
V
S
G
V
I
T
V
H
N
V
F
S
K
--
E
Q
T
I
--
Q
L
P
S
-----
K
F
T
C
----
S
C
N
S
L
T
V
D
G
N
------
N
A
---
N
Y
I
Y
A
G
Y
E
N
G
--
M
L
---
A
Q
W
D
L
R
----
S
--------
P
E
C
--------
P
V
G
E
F
L
I
N
E
G
T
P
I
--
N
N
V
Y
F
A
A
G
A
L
F
V
S
S
----------
G
F
D
T
S
I
K
L
D
I
I
S
D
P
E
S
-
E
R
P
A
I
-----------------
E
F
E
T
P
T
F
L
V
-
S
N
--
D
------------------------------------------
D
--------
E
V
S
Q
-----
F
C
Y
V
-------
S
D
---------------------------------------
D
E
S
--
N
G
E
V
L
E
V
G
K
N
N
F
C
-------
A
L
Y
N
L
S
N
P
-----
18
PsiBlast_PDB
35.81
26%
33
* C4 *
2WRH
1
HEMA_I76A4
H:
[156-242]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
K
L
S
K
-------
S
-----------
Y
T
---
N
N
K
G
K
E
V
L
V
-
L
W
G
-
V
H
H
P
-
P
S
V
S
E
Q
Q
S
L
Y
Q
---
N
A
D
A
Y
V
S
-----------------
V
G
S
S
K
Y
N
R
R
F
A
P
EI
A
A
R
P
--
K
V
R
G
-----
Q
A
G
---
R
M
N
Y
Y
W
T
L
L
D
Q
G
------
D
T
I
T
F
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
35.62
14%
52
- C6 -
2GJ2
3
?
A:
[5-83]
----------------------------------------------------------------------------------------------------------------
A
T
----
F
-----
Q
-
T
D
-
A
D
-----
F
L
L
V
G
D
D
T
S
R
--
Y
E
E
V
M
K
T
F
D
-
T
---
V
-
E
A
V
R
K
S
D
-------
L
D
D
R
V
Y
M
V
C
L
K
Q
G
S
T
--
F
V
L
-----
N
G
-----------
G
I
-
E
E
L
R
L
L
T
-
G
D
ST
L
E
I
Q
P
M
I
V
P
------
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
34.66
33%
49
- C7 -
1BYL
-
BLE_STRHI
A:
[24-77]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
--
R
L
G
F
S
R
D
F
--
V
E
D
D
F
A
G
V
V
R
D
D
V
T
L
-----
F
I
S
A
V
--
Q
D
Q
V
V
P
D
--------
N
T
L
A
-----
W
V
W
V
-------
R
G
L
D
E
L
Y
A
E
----------------------------------------------------------------------