@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0422: (2016-03-15 )
MKRLIGLVIVALVLLAACGSNNDKKVTIGVASNDTKAWEKVKELAKKDDIDVEIKHFSDYNLPNKALNDGDIDMNAFQHFAFLDQYKKAHKGTKISALSTTVLAPLGIYSDKIKDVKKVKDGAKVVIPNDVSNQARALKLLEAAGLIKLKKDFGLAGTVKDITSNPKHLKITAVDAQQTARALSDVDIAVINNGVATKAGKDPKNDPIFLEKSNSDAVKPYINIVAVNDKDLDNKTYAKIVELYHSKEAQKALQEDVKDGEKPVNLSKDEIKAIETSLAK
Atome Classification :
(22 SA)
.........10........20--........-30...--..---....40....-.-...50........60........70........80........-90........100.......110.......120........130.......140.......150..-.-..---..160.......170.......180......--.190.......200.......210.......220.......230.......240.......250.......260.......270.......280
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
R
L
I
G
L
V
I
V
A
L
V
L
L
A
ACGSN--ND
K
K
V
T
I
G
-V-ASN--
D
T
---
K
A
W
E
K
V
K
E
L
A
-K-KDDI
D
V
E
I
K
HFSDYNLPNKALNDGDI
D
M
N
A
F
Q
H
F
A
F
L
D
Q
Y
K
K
A
-HKG
T
K
I
S
A
L
S
T
T
V
L
A
PLGI
Y
S
D
K
I
K
D
V
K
K
VKD-G
A
K
V
V
IPNDVS
N
Q
A
R
A
L
K
L
L
E
AA
G
L
I
K
L
K
K
DFG-L-AG---
T
V
K
D
ITSNP
K
H
L
K
I
T
A
V
D
A
Q
Q
T
A
R
A
LSD
V
D
I
--
A
V
INNGVATKAGKDPKND
P
I
F
L
EKSNSDAV
K
P
Y
I
N
I
V
A
VNDKDLD
N
K
T
Y
A
K
I
V
E
L
Y
H
S
K
E
A
Q
K
A
L
Q
E
D
V
KDGEKPVNL
S
K
D
E
I
K
A
I
E
T
SLAK
60
Fugue
96.65
100%
-74
- C2 -
1P99
2
?
A:
[40-294]
--------------------------
K
V
T
I
G
-
V
-
A
S
N
--
D
T
---
K
A
W
E
K
V
K
E
L
A
-
K
-
K
D
D
I
D
V
E
I
K
H
F
S
D
Y
N
L
P
N
K
A
L
N
D
G
D
I
D
M
N
A
F
Q
H
F
A
F
L
D
Q
Y
K
K
A
-
H
K
G
T
K
I
S
A
L
S
T
T
V
L
A
P
L
G
I
Y
S
D
K
I
K
D
V
K
K
V
K
D
-
G
A
K
V
V
I
P
N
D
V
S
N
Q
A
R
A
L
K
L
L
E
A
A
G
L
I
K
L
K
K
D
F
G
-
L
-
A
G
---
T
V
K
D
I
T
S
N
P
K
H
L
K
I
T
A
V
D
A
Q
Q
T
A
R
A
L
S
D
V
D
I
--
A
V
I
N
N
G
V
A
T
K
A
G
K
D
P
K
N
D
P
I
F
L
E
K
S
N
S
D
A
V
K
P
Y
I
N
I
V
A
V
N
D
K
D
L
D
N
K
T
Y
A
K
I
V
E
L
Y
H
S
K
E
A
Q
K
A
L
Q
E
D
V
K
D
G
E
K
P
V
N
L
S
K
D
E
I
K
A
I
E
T
S
L
A
-
40
HHSearch
96.45
99%
-74
- C2 -
1P99
2
?
A:
[40-294]
--------------------------
K
V
T
I
G
-
V
-
A
S
N
--
D
T
---
K
A
W
E
K
V
K
E
L
A
-
K
-
K
D
D
I
D
V
E
I
K
H
F
S
D
Y
N
L
P
N
K
A
L
N
D
G
D
I
D
M
N
A
F
Q
H
F
A
F
L
D
Q
Y
K
K
A
H
K
-
G
T
K
I
S
A
L
S
T
T
V
L
A
P
L
G
I
Y
S
D
K
I
K
D
V
K
K
V
-
K
D
G
A
K
V
V
I
P
N
D
V
S
N
Q
A
R
A
L
K
L
L
E
A
A
G
L
I
K
L
K
K
D
F
G
-
L
-
A
G
---
T
V
K
D
I
T
S
N
P
K
H
L
K
I
T
A
V
D
A
Q
Q
T
A
R
A
L
S
D
V
D
I
--
A
V
I
N
N
G
V
A
T
K
A
G
K
D
P
K
N
D
P
I
F
L
E
K
S
N
S
D
A
V
K
P
Y
I
N
I
V
A
V
N
D
K
D
L
D
N
K
T
Y
A
K
I
V
E
L
Y
H
S
K
E
A
Q
K
A
L
Q
E
D
V
K
D
G
E
K
P
V
N
L
S
K
D
E
I
K
A
I
E
T
S
L
A
-
1
PsiBlast_PDB
96.44
99%
-74
- C2 -
1P99
2
?
A:
[40-294]
--------------------------
K
V
T
I
G
-
V
-
A
S
N
--
D
T
---
K
A
W
E
K
V
K
E
L
A
-
K
-
K
D
D
I
D
V
E
I
K
H
F
S
D
Y
N
L
P
N
K
A
L
N
D
G
D
I
D
M
N
A
F
Q
H
F
A
F
L
D
Q
Y
K
K
A
-
H
K
G
T
K
I
S
A
L
S
T
T
V
L
A
P
L
G
I
Y
S
D
K
I
K
D
V
K
K
V
K
D
-
G
A
K
V
V
I
P
N
D
V
S
N
Q
A
R
A
L
K
L
L
E
A
A
G
L
I
K
L
K
K
D
F
G
-
L
-
A
G
---
T
V
K
D
I
T
S
N
P
K
H
L
K
I
T
A
V
D
A
Q
Q
T
A
R
A
L
S
D
V
D
I
--
A
V
I
N
N
G
V
A
T
K
A
G
K
D
P
K
N
D
P
I
F
L
E
K
S
N
S
D
A
V
K
P
Y
I
N
I
V
A
V
N
D
K
D
L
D
N
K
T
Y
A
K
I
V
E
L
Y
H
S
K
E
A
Q
K
A
L
Q
E
D
V
K
D
G
E
K
P
V
N
L
S
K
D
E
I
K
A
I
E
T
S
L
A
-
2
PsiBlast_PDB
77.66
43%
-61
- C2 -
4QHQ
2
?
A:
[7-234]
--------------------------------
V
-
A
G
P
--
D
S
---
E
V
W
Q
V
V
Q
K
V
A
-
K
E
K
E
G
L
N
V
K
V
I
E
F
N
D
Y
V
Q
P
N
A
A
L
D
S
G
D
L
D
A
N
S
F
Q
H
Q
P
Y
L
D
S
Q
V
K
--
Q
R
G
Y
K
I
V
S
A
G
L
T
Y
I
S
P
I
G
V
Y
S
K
K
F
K
S
L
K
D
L
P
Q
-
G
A
K
L
A
V
P
N
D
P
S
N
E
N
R
A
L
L
L
L
Q
T
Q
G
V
I
K
L
K
A
G
A
G
-
T
-
G
G
N
N
A
T
V
L
D
I
A
E
N
P
K
K
L
K
I
S
E
L
D
A
A
Q
L
P
R
V
L
S
D
V
D
A
--
A
V
I
N
T
N
Y
A
L
A
A
N
L
Q
P
T
K
D
A
I
A
L
E
S
L
T
S
----
P
Y
A
N
L
I
A
V
R
A
K
D
K
D
Q
P
W
V
K
K
L
V
K
A
Y
Q
S
P
E
V
K
E
F
I
K
K
Q
F
K
----------------------
6
PsiBlast_PDB
74.71
37%
-65
- C2 -
3K2D
1
?
A:
[1-237]
------------------
G
H
M
--
D
T
S
K
V
K
V
G
-
V
M
A
G
A
--
E
A
---
Q
V
A
E
V
A
A
K
V
A
-
K
E
K
Y
G
L
D
V
E
L
V
T
F
T
D
Y
V
T
P
N
A
A
L
D
D
G
S
I
D
M
N
A
F
Q
H
K
P
Y
L
D
R
-
Q
V
E
-
D
R
D
Y
K
L
T
I
A
G
N
T
F
V
Y
P
I
A
G
Y
S
K
Q
V
K
S
V
A
A
L
A
D
-
G
V
R
I
A
V
P
N
D
P
T
N
L
G
R
S
L
L
L
L
E
Q
Q
G
L
I
K
L
R
P
E
V
G
-
L
-
L
A
---
T
V
R
D
I
V
E
N
P
K
N
I
T
I
M
E
L
D
A
A
Q
L
P
R
S
L
D
D
V
A
L
--
S
I
I
N
T
T
Y
A
S
S
I
N
L
T
P
E
K
D
G
V
F
V
E
D
K
E
S
----
P
Y
V
N
L
I
V
A
R
Q
D
N
V
Q
N
E
N
V
Q
N
F
V
K
A
Y
Q
T
E
E
V
Y
T
A
A
K
E
I
F
K
----------------------
42
HHSearch
74.63
33%
-63
- C2 -
1XS5
1
TPN32_TREPA
A:
[2-237]
------------------------
D
E
T
V
G
V
G
-
V
-
L
S
E
P
-
H
A
---
R
L
L
E
I
A
K
E
E
V
-
K
-
K
Q
H
I
E
L
R
I
V
E
F
T
N
Y
V
A
L
N
E
A
V
M
R
G
D
I
L
M
N
F
F
Q
H
V
P
H
M
Q
Q
F
N
Q
E
-
H
-
N
G
D
L
V
S
V
G
N
V
H
V
E
P
L
A
L
Y
S
R
T
Y
R
H
V
S
D
F
P
A
-
G
A
V
I
A
I
P
N
D
S
S
N
E
A
R
A
L
R
L
L
E
A
A
G
F
I
R
M
R
A
G
S
G
-
L
-
F
A
---
T
V
E
D
V
Q
Q
N
V
R
N
V
V
L
Q
E
V
E
S
A
L
L
P
R
V
F
D
Q
V
D
G
--
A
V
I
N
G
N
Y
A
I
M
A
G
L
S
A
R
R
D
G
L
A
V
E
P
----
D
A
S
A
Y
A
N
V
L
V
V
K
R
G
N
E
A
D
A
R
V
Q
A
V
L
R
A
L
C
G
G
R
V
R
T
Y
L
K
E
R
Y
K
G
G
E
V
------------------
4
PsiBlast_PDB
73.76
41%
-51
- C2 -
4YAH
1
METQ_ECOLI
X:
[29-258]
---------------------DP
N
H
I
K
V
G
V
I
-
V
-
G
A
E
--
Q
Q
---
V
A
-
E
V
A
Q
K
V
A
-
K
D
K
Y
G
L
D
V
E
L
V
T
F
N
D
Y
V
L
P
N
E
A
L
S
K
G
D
I
D
A
N
A
F
Q
H
K
P
Y
L
D
Q
Q
L
K
--
D
R
G
Y
K
L
V
A
V
G
N
T
F
V
Y
P
I
A
G
Y
S
K
K
I
K
S
L
D
E
L
Q
D
-
G
S
Q
V
A
V
P
N
D
P
T
N
L
G
R
S
L
L
L
L
Q
K
V
G
L
I
K
L
K
D
G
V
G
-
L
-
L
P
---
T
V
L
D
V
V
E
N
P
K
N
L
K
I
V
E
L
E
A
P
Q
L
P
R
S
L
D
D
A
Q
I
AL
A
V
I
N
T
T
Y
A
S
Q
I
G
L
T
P
A
K
D
G
I
F
V
E
D
K
E
S
----
P
Y
V
N
L
I
V
T
R
E
D
N
K
D
A
E
N
V
K
K
F
V
Q
A
Y
Q
S
D
E
V
Y
E
A
----------------------------
9
PsiBlast_PDB
73.24
33%
-58
- C2 -
1XS5
1
TPN32_TREPA
A:
[2-236]
------------------------
D
E
T
V
G
V
G
-
V
-
L
S
E
P
-
H
A
---
R
L
L
E
I
A
K
E
E
V
-
K
-
K
Q
H
I
E
L
R
I
V
E
F
T
N
Y
V
A
L
N
E
A
V
M
R
G
D
I
L
M
N
F
F
Q
H
V
P
H
M
Q
Q
F
N
Q
E
-
H
N
G
D
L
V
S
V
G
N
V
H
V
-
E
P
L
A
L
Y
S
R
T
Y
R
H
V
S
D
F
P
A
-
G
A
V
I
A
I
P
N
D
S
S
N
E
A
R
A
L
R
L
L
E
A
A
G
F
I
R
M
R
A
G
S
G
-
L
-
F
A
---
T
V
E
D
V
Q
Q
N
V
R
N
V
V
L
Q
E
V
E
S
A
L
L
P
R
V
F
D
Q
V
D
G
--
A
V
I
N
G
N
Y
A
I
M
A
G
L
S
A
R
R
D
G
L
A
V
E
P
D
A
S
----
A
Y
A
N
V
L
V
V
K
R
G
N
E
A
D
A
R
V
Q
A
V
L
R
A
L
C
G
G
R
V
R
T
Y
L
K
E
R
Y
K
G
G
E
-------------------
43
HHSearch
72.92
41%
-62
- C2 -
3TQW
1
?
A:
[4-239]
--------------------------
M
V
R
V
G
-
T
-
I
A
G
P
-
E
T
---
Q
L
M
E
V
A
K
Q
V
A
L
N
-
R
Y
G
L
H
V
N
I
I
T
F
S
D
Y
N
T
P
N
E
A
L
A
D
G
S
V
D
A
N
M
F
Q
H
L
P
Y
L
K
A
Q
I
E
M
-
R
-
G
Y
K
I
V
S
I
G
K
T
F
V
Y
P
M
G
L
Y
S
K
K
I
T
A
L
T
Q
L
K
T
-
G
A
K
I
A
V
P
S
D
P
S
N
E
A
R
A
L
L
L
L
E
K
A
Q
L
I
Q
L
K
T
H
---
I
-
N
A
---
T
P
M
D
I
A
S
N
P
K
K
L
K
I
V
E
L
D
A
A
Q
L
S
R
S
L
G
D
V
D
L
--
A
A
I
N
T
N
Y
A
I
P
A
G
L
S
P
S
R
D
A
L
L
T
E
G
----
P
N
S
P
Y
A
N
V
V
A
V
R
E
D
D
K
N
D
P
R
L
K
Q
L
V
S
A
L
H
S
P
A
V
L
S
A
A
K
K
I
F
G
D
G
A
I
P
-----------------
21
PsiBlast_CBE
72.18
37%
-65
- C2 -
3K2D
1
?
B:
[8-237]
---------------------------
V
K
V
G
-
V
M
A
G
A
--
E
A
---
Q
V
A
E
V
A
A
K
V
A
-
K
E
K
Y
G
L
D
V
E
L
V
T
F
T
D
Y
V
T
P
N
A
A
L
D
D
G
S
I
D
M
N
A
F
Q
H
K
P
Y
L
D
R
-
Q
V
E
-
D
R
D
Y
K
L
T
I
A
G
N
T
F
V
Y
P
I
A
G
Y
S
K
Q
V
K
S
V
A
A
L
A
D
-
G
V
R
I
A
V
P
N
D
P
T
N
L
G
R
S
L
L
L
L
E
Q
Q
G
L
I
K
L
R
P
E
V
G
-
L
-
L
A
---
T
V
R
D
I
V
E
N
P
K
N
I
T
I
M
E
L
D
A
A
Q
L
P
R
S
L
D
D
V
A
L
--
S
I
I
N
T
T
Y
A
S
S
I
N
L
T
P
E
K
D
G
V
F
V
E
D
K
E
S
----
P
Y
V
N
L
I
V
A
R
Q
D
N
V
Q
N
E
N
V
Q
N
F
V
K
A
Y
Q
T
E
E
V
Y
T
A
A
K
E
I
F
K
----------------------
3
PsiBlast_PDB
72.11
40%
-59
- C2 -
3TQW
1
?
A:
[4-239]
--------------------------
M
V
R
V
G
T
I
-
A
G
P
--
E
T
---
Q
L
M
E
V
A
K
Q
V
A
L
N
-
R
Y
G
L
H
V
N
I
I
T
F
S
D
Y
N
T
P
N
E
A
L
A
D
G
S
V
D
A
N
M
F
Q
H
L
P
Y
L
-
K
A
Q
I
E
-
M
R
G
Y
K
I
V
S
I
G
K
T
F
V
Y
P
M
G
L
Y
S
K
K
I
T
A
L
T
Q
L
K
T
-
G
A
K
I
A
V
P
S
D
P
S
N
E
A
R
A
L
L
L
L
E
K
A
Q
L
I
Q
L
K
T
H
---
I
-
N
A
---
T
P
M
D
I
A
S
N
P
K
K
L
K
I
V
E
L
D
A
A
Q
L
S
R
S
L
G
D
V
D
L
--
A
A
I
N
T
N
Y
A
I
P
A
G
L
S
P
S
R
D
A
L
L
T
E
G
P
N
S
----
P
Y
A
N
V
V
A
V
R
E
D
D
K
N
D
P
R
L
K
Q
L
V
S
A
L
H
S
P
A
V
L
S
A
A
K
K
I
F
G
D
G
A
I
P
-----------------
10
PsiBlast_PDB
69.57
37%
-63
- C2 -
3IR1
6
?
A:
[18-219]
-----------------------------------------------
E
Q
I
Q
P
E
L
-
E
-
K
K
G
Y
T
V
K
L
V
E
F
T
D
Y
V
R
P
N
L
A
L
A
E
G
E
L
D
I
N
V
F
Q
H
K
P
Y
L
D
D
F
K
K
E
-
H
N
-
L
D
I
T
E
V
F
Q
V
P
T
A
P
L
G
L
Y
P
G
K
L
K
S
L
E
E
V
K
D
-
G
S
T
V
S
A
P
N
D
P
S
N
F
A
R
V
L
V
M
L
D
E
L
G
W
I
K
L
K
D
G
I
N
P
L
-
T
A
---
S
K
A
D
I
A
E
N
L
K
N
I
K
I
V
E
L
E
A
A
Q
L
P
R
S
R
A
D
V
D
F
--
A
V
V
N
G
N
Y
A
I
S
S
G
M
K
-
L
T
E
A
L
F
Q
E
P
S
F
A
-----
Y
V
N
W
S
A
V
K
T
A
D
K
D
S
Q
W
L
K
D
V
T
E
A
Y
N
S
----------------------------------
29
PsiBlast_CBE
69.07
37%
-62
- C2 -
3GXA
2
?
E:
[40-241]
-----------------------------------------------
E
Q
I
Q
P
E
L
-
E
-
K
K
G
Y
T
V
K
L
V
E
F
T
D
Y
V
R
P
N
L
A
L
A
E
G
E
L
D
I
N
V
F
Q
H
K
P
Y
L
D
D
F
K
K
E
-
H
N
-
L
D
I
T
E
V
F
Q
V
P
T
A
P
L
G
L
Y
P
G
K
L
K
S
L
E
E
V
K
D
-
G
S
T
V
S
A
P
N
D
P
S
N
F
A
R
V
L
V
M
L
D
E
L
G
W
I
K
L
K
D
G
I
N
P
L
-
T
A
---
S
K
A
D
I
A
E
N
L
K
N
I
K
I
V
E
L
E
A
A
Q
L
P
R
S
R
A
D
V
D
F
--
A
V
V
N
G
N
Y
A
I
S
S
G
M
K
-
L
T
E
A
L
F
Q
E
P
S
F
A
-----
Y
V
N
W
S
A
V
K
T
A
D
K
D
S
Q
W
L
K
D
V
T
E
A
Y
N
S
----------------------------------
27
PsiBlast_CBE
69.00
37%
-58
- C2 -
3IR1
4
?
B:
[18-219]
-----------------------------------------------
E
Q
I
Q
P
E
L
-
E
-
K
K
G
Y
T
V
K
L
V
E
F
T
D
Y
V
R
P
N
L
A
L
A
E
G
E
L
D
I
N
V
F
Q
H
K
P
Y
L
D
D
F
K
K
E
-
H
N
-
L
D
I
T
E
V
F
Q
V
P
T
A
P
L
G
L
Y
P
G
K
L
K
S
L
E
E
V
K
D
-
G
S
T
V
S
A
P
N
D
P
S
N
F
A
R
V
L
V
M
L
D
E
L
G
W
I
K
L
K
D
G
I
N
P
L
-
T
A
---
S
K
A
D
I
A
E
N
L
K
N
I
K
I
V
E
L
E
A
A
Q
L
P
R
S
R
A
D
V
D
F
--
A
V
V
N
G
N
Y
A
I
S
S
G
M
K
-
L
T
E
A
L
F
Q
E
P
S
F
A
-----
Y
V
N
W
S
A
V
K
T
A
D
K
D
S
Q
W
L
K
D
V
T
E
A
Y
N
S
----------------------------------
32
PsiBlast_CBE
68.94
37%
-62
- C2 -
3GXA
8
?
B:
[40-241]
-----------------------------------------------
E
Q
I
Q
P
E
L
-
E
-
K
K
G
Y
T
V
K
L
V
E
F
T
D
Y
V
R
P
N
L
A
L
A
E
G
E
L
D
I
N
V
F
Q
H
K
P
Y
L
D
D
F
K
K
E
-
H
N
-
L
D
I
T
E
V
F
Q
V
P
T
A
P
L
G
L
Y
P
G
K
L
K
S
L
E
E
V
K
D
-
G
S
T
V
S
A
P
N
D
P
S
N
F
A
R
V
L
V
M
L
D
E
L
G
W
I
K
L
K
D
G
I
N
P
L
-
T
A
---
S
K
A
D
I
A
E
N
L
K
N
I
K
I
V
E
L
E
A
A
Q
L
P
R
S
R
A
D
V
D
F
--
A
V
V
N
G
N
Y
A
I
S
S
G
M
K
-
L
T
E
A
L
F
Q
E
P
S
F
A
-----
Y
V
N
W
S
A
V
K
T
A
D
K
D
S
Q
W
L
K
D
V
T
E
A
Y
N
S
----------------------------------
46
HHSearch
68.59
33%
-49
- C2 -
3IR1
6
?
A:
[2-237]
--------------------------
E
I
V
F
G
-
T
-
T
V
G
D
F
G
D
---
M
V
K
E
Q
I
Q
P
E
L
-
E
-
K
K
G
Y
T
V
K
L
V
E
F
T
D
Y
V
R
P
N
L
A
L
A
E
G
E
L
D
I
N
V
F
Q
H
K
P
Y
L
D
D
F
K
K
E
-
H
-
N
L
D
I
T
E
V
F
Q
V
P
T
A
P
L
G
L
Y
P
G
K
L
K
S
L
E
E
V
K
D
-
G
S
T
V
S
A
P
N
D
P
S
N
F
A
R
V
L
V
M
L
D
E
L
G
W
I
K
L
K
D
G
I
N
-
P
L
T
A
---
S
K
A
D
I
A
E
N
L
K
N
I
K
I
V
E
L
E
A
A
Q
L
P
R
S
R
A
D
V
D
F
--
A
V
V
N
G
N
Y
A
I
S
S
G
M
K
L
-
T
E
A
L
F
Q
E
P
----
S
-
F
A
Y
V
N
W
S
A
V
K
T
A
D
K
D
S
Q
W
L
K
D
V
T
E
A
Y
N
S
D
A
F
K
A
Y
A
H
K
R
F
E
G
Y
K
S
P
A
----------------
25
PsiBlast_CBE
68.37
37%
-63
- C2 -
3IR1
4
?
D:
[18-219]
-----------------------------------------------
E
Q
I
Q
P
E
L
-
E
-
K
K
G
Y
T
V
K
L
V
E
F
T
D
Y
V
R
P
N
L
A
L
A
E
G
E
L
D
I
N
V
F
Q
H
K
P
Y
L
D
D
F
K
K
E
-
H
N
-
L
D
I
T
E
V
F
Q
V
P
T
A
P
L
G
L
Y
P
G
K
L
K
S
L
E
E
V
K
D
-
G
S
T
V
S
A
P
N
D
P
S
N
F
A
R
V
L
V
M
L
D
E
L
G
W
I
K
L
K
D
G
I
N
P
L
-
T
A
---
S
K
A
D
I
A
E
N
L
K
N
I
K
I
V
E
L
E
A
A
Q
L
P
R
S
R
A
D
V
D
F
--
A
V
V
N
G
N
Y
A
I
S
S
G
M
K
-
L
T
E
A
L
F
Q
E
P
S
F
A
-----
Y
V
N
W
S
A
V
K
T
A
D
K
D
S
Q
W
L
K
D
V
T
E
A
Y
N
S
----------------------------------
28
PsiBlast_CBE
68.34
37%
-64
- C2 -
3GXA
7
?
F:
[40-241]
-----------------------------------------------
E
Q
I
Q
P
E
L
-
E
-
K
K
G
Y
T
V
K
L
V
E
F
T
D
Y
V
R
P
N
L
A
L
A
E
G
E
L
D
I
N
V
F
Q
H
K
P
Y
L
D
D
F
K
K
E
-
H
N
-
L
D
I
T
E
V
F
Q
V
P
T
A
P
L
G
L
Y
P
G
K
L
K
S
L
E
E
V
K
D
-
G
S
T
V
S
A
P
N
D
P
S
N
F
A
R
V
L
V
M
L
D
E
L
G
W
I
K
L
K
D
G
I
N
P
L
-
T
A
---
S
K
A
D
I
A
E
N
L
K
N
I
K
I
V
E
L
E
A
A
Q
L
P
R
S
R
A
D
V
D
F
--
A
V
V
N
G
N
Y
A
I
S
S
G
M
K
-
L
T
E
A
L
F
Q
E
P
S
F
A
-----
Y
V
N
W
S
A
V
K
T
A
D
K
D
S
Q
W
L
K
D
V
T
E
A
Y
N
S
----------------------------------
23
PsiBlast_CBE
68.22
37%
-58
- C2 -
3IR1
3
?
F:
[18-219]
-----------------------------------------------
E
Q
I
Q
P
E
L
-
E
-
K
K
G
Y
T
V
K
L
V
E
F
T
D
Y
V
R
P
N
L
A
L
A
E
G
E
L
D
I
N
V
F
Q
H
K
P
Y
L
D
D
F
K
K
E
-
H
N
-
L
D
I
T
E
V
F
Q
V
P
T
A
P
L
G
L
Y
P
G
K
L
K
S
L
E
E
V
K
D
-
G
S
T
V
S
A
P
N
D
P
S
N
F
A
R
V
L
V
M
L
D
E
L
G
W
I
K
L
K
D
G
I
N
P
L
-
T
A
---
S
K
A
D
I
A
E
N
L
K
N
I
K
I
V
E
L
E
A
A
Q
L
P
R
S
R
A
D
V
D
F
--
A
V
V
N
G
N
Y
A
I
S
S
G
M
K
-
L
T
E
A
L
F
Q
E
P
S
F
A
-----
Y
V
N
W
S
A
V
K
T
A
D
K
D
S
Q
W
L
K
D
V
T
E
A
Y
N
S
----------------------------------
30
PsiBlast_CBE
68.07
37%
-59
- C2 -
3GXA
6
?
D:
[40-241]
-----------------------------------------------
E
Q
I
Q
P
E
L
-
E
-
K
K
G
Y
T
V
K
L
V
E
F
T
D
Y
V
R
P
N
L
A
L
A
E
G
E
L
D
I
N
V
F
Q
H
K
P
Y
L
D
D
F
K
K
E
-
H
N
-
L
D
I
T
E
V
F
Q
V
P
T
A
P
L
G
L
Y
P
G
K
L
K
S
L
E
E
V
K
D
-
G
S
T
V
S
A
P
N
D
P
S
N
F
A
R
V
L
V
M
L
D
E
L
G
W
I
K
L
K
D
G
I
N
P
L
-
T
A
---
S
K
A
D
I
A
E
N
L
K
N
I
K
I
V
E
L
E
A
A
Q
L
P
R
S
R
A
D
V
D
F
--
A
V
V
N
G
N
Y
A
I
S
S
G
M
K
-
L
T
E
A
L
F
Q
E
P
S
F
A
-----
Y
V
N
W
S
A
V
K
T
A
D
K
D
S
Q
W
L
K
D
V
T
E
A
Y
N
S
----------------------------------
8
PsiBlast_PDB
66.86
37%
-58
- C2 -
4IB2
7
?
A:
[6-216]
-------------------
S
S
--
E
D
A
K
-
T
I
K
-
V
-
A
A
S
--
A
T
P
H
A
E
I
L
E
Q
A
K
S
I
L
-
K
-
K
E
G
Y
Q
L
E
V
T
V
F
D
D
Y
V
Q
P
N
E
V
V
E
S
G
E
F
D
A
N
Y
F
Q
H
V
P
Y
L
E
S
F
N
E
--
E
K
G
T
H
L
V
D
A
G
D
I
H
Y
E
P
F
G
I
Y
P
G
T
K
K
S
L
D
E
I
S
E
-
G
D
K
I
A
V
P
N
D
T
T
N
E
A
R
A
L
L
L
L
Q
D
N
G
I
I
T
L
K
D
G
A
G
-
L
-
N
A
---
T
V
N
D
I
E
E
N
P
Y
N
V
E
I
V
E
L
E
A
A
Q
V
A
R
V
T
G
E
T
A
Y
--
V
V
L
N
G
N
Y
A
L
E
A
G
Y
S
V
A
K
D
A
L
A
Y
E
K
S
D
S
E
A
A
K
T
Y
V
N
I
I
A
V
K
E
---------------------------------------------------
22
PsiBlast_CBE
66.37
37%
-60
- C2 -
4IB2
8
?
B:
[10-216]
-------------------------
A
K
-
T
I
K
-
V
-
A
A
S
--
A
T
P
H
A
E
I
L
E
Q
A
K
S
I
L
-
K
-
K
E
G
Y
Q
L
E
V
T
V
F
D
D
Y
V
Q
P
N
E
V
V
E
S
G
E
F
D
A
N
Y
F
Q
H
V
P
Y
L
E
S
F
N
E
--
E
K
G
T
H
L
V
D
A
G
D
I
H
Y
E
P
F
G
I
Y
P
G
T
K
K
S
L
D
E
I
S
E
-
G
D
K
I
A
V
P
N
D
T
T
N
E
A
R
A
L
L
L
L
Q
D
N
G
I
I
T
L
K
D
G
A
G
-
L
-
N
A
---
T
V
N
D
I
E
E
N
P
Y
N
V
E
I
V
E
L
E
A
A
Q
V
A
R
V
T
G
E
T
A
Y
--
V
V
L
N
G
N
Y
A
L
E
A
G
Y
S
V
A
K
D
A
L
A
Y
E
K
S
D
S
E
A
A
K
T
Y
V
N
I
I
A
V
K
E
---------------------------------------------------