@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0884: (2016-03-19 )
MKFISNNNITDPTLNLAMEEYVLKNLPAEESYFLFYINRPSIIVGKNQNTIEEVNQTYIDAHNIDVVRRISGGGAVYHDTGNLNFSFITDDDGNSFHNFQKFTEPIVQALQSLGVNAELTGRNDIQVGQAKISGNAMVKVKNRMFSHGTLMLNSDLDEVQNALKVNPAKIKSKGIKSVRKRVANIQEFLNDPLEIEEFKKIILKTIFGETEVEEYKLTDEDWENIEKLSNDKYRTWAWNYGRNPKYNFEREEKFEKGFVQIKFDVKRGKIEHAKIFGDFFGVGDVTDLENALVGCLHDFEHIEEALSEYDLYHYFGDIDRHELIRLMS
Atome Classification :
(23 SA)
.........10........20......-.-.30....-....40........50........60........70........80.......-.90.-.......100.......110.--.....----------.120---------......----..-130.......140.......150.......160.......170.......180.......190-.......200.......--210-.-..--.----.-....---220........230---..--.....240.......250..--.--....260--.......270...-....-280..-...-..290.......300.......310.-......320......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
FISNNNITD
P
T
L
N
L
A
M
E
E
Y
V
L
KNLP-A-EE
S
Y
F
L
F
-
Y
INRP
S
I
I
VGKNQ
N
T
I
E
E
V
N
Q
T
Y
IDAHN
I
D
V
V
R
RISGG
G
A
V
Y
H
DTGN
L
N
F
S
F
I
-TDDD-GNSFH
N
F
Q
K
F
T
E
P
I
V
Q
A
L
Q
SL--GV
N
A
E
----------LTG----------RND
I
Q
V----G
Q
-
A
K
ISG
N
A
M
V
K
VKNRMFSH
G
T
L
M
LNS
D
L
D
E
V
Q
N
A
LKV
N
P
A
K
I
K
S
K
G
I
K
S
V
R
K
R
V
A
N
I
Q
E
FLNDP-L
E
I
E
E
F
K
K
I
I
L
K
T
IFGE--T---E-V
E
--
E
----
Y
-KLT
D
---
E
D
-
W
E
N
I
E
K
LSNDK---
Y
R
--
T
W
A
WNYGRNPKYN
F
E
R
E
E
K
F--E--KG
F
V
Q
I
K
--
F
D
VKRG
K
I
E
H
A
K
I
-
F
G
D
F-FGVG
D
-
V
T
D
-
L
E
N
A
L
V
G
C
L
H
D
F
E
H
I
E
E
A
L
S
EY
D
L
Y
H
-YFGDI
D
R
H
E
L
I
R
LMS
29
HHSearch
98.37
43%
-85
- C4 -
1VQZ
18
?
A:
[13-340]
M
K
Y
I
I
-
N
H
S
N
D
T
A
F
N
I
A
L
E
E
Y
A
F
K
H
L
L
-
D
-
E
D
Q
I
F
L
L
-
W
I
N
K
P
S
I
I
V
G
R
H
Q
N
T
I
E
E
I
N
R
D
Y
V
R
E
N
G
I
E
V
V
R
R
I
S
G
G
G
A
V
Y
H
D
L
N
N
L
N
Y
T
I
I
-
S
K
E
D
-
E
N
K
A
F
D
F
K
S
F
S
T
P
V
I
N
T
L
A
Q
L
--
G
V
K
A
E
----------
F
T
G
----------
R
N
D
L
E
I
----
D
G
-
K
K
F
C
G
N
A
Q
A
Y
I
N
G
R
I
M
H
H
G
C
L
L
F
D
V
D
L
S
V
L
A
N
A
L
K
V
S
K
D
K
F
E
S
K
G
V
K
S
V
R
A
R
V
T
N
I
I
N
E
L
P
K
K
-
I
T
V
E
K
F
R
D
L
L
L
E
Y
M
K
K
E
--
Y
---
P
E
M
T
--
E
----
Y
-
V
F
S
E
---
E
E
-
L
A
E
I
N
R
I
K
D
T
K
---
F
G
--
T
W
D
W
N
Y
G
K
S
P
E
F
N
V
R
R
G
I
K
F
--
T
--
S
G
K
V
E
V
F
--
A
N
V
T
E
S
K
I
Q
D
I
K
I
-
Y
G
D
F
-
F
G
I
E
D
-
V
A
A
-
V
E
D
V
L
R
G
V
K
Y
E
R
E
D
V
L
K
A
L
K
T
I
D
I
T
R
-
Y
F
A
G
I
S
R
E
E
I
A
E
A
V
V
1
PsiBlast_PDB
97.10
43%
-78
- C4 -
1VQZ
18
?
A:
[14-335]
-
K
Y
I
I
N
H
S
-
N
D
T
A
F
N
I
A
L
E
E
Y
A
F
K
H
L
L
-
D
-
E
D
Q
I
F
L
L
-
W
I
N
K
P
S
I
I
V
G
R
H
Q
N
T
I
E
E
I
N
R
D
Y
V
R
E
N
G
I
E
V
V
R
R
I
S
G
G
G
A
V
Y
H
D
L
N
N
L
N
Y
T
I
I
-
S
K
E
D
-
E
N
K
A
F
D
F
K
S
F
S
T
P
V
I
N
T
L
A
Q
L
--
G
V
K
A
E
----------
F
T
G
----------
R
N
D
L
E
I
----
D
G
-
K
K
F
C
G
N
A
Q
A
Y
I
N
G
R
I
M
H
H
G
C
L
L
F
D
V
D
L
S
V
L
A
N
A
L
K
V
S
K
D
K
F
E
S
K
G
V
K
S
V
R
A
R
V
T
N
I
I
N
E
L
P
K
K
-
I
T
V
E
K
F
R
D
L
L
L
E
Y
M
K
K
E
Y
-
P
---
E
-
M
T
--
E
----
Y
-
V
F
S
E
---
E
E
-
L
A
E
I
N
R
I
K
D
T
K
---
F
G
--
T
W
D
W
N
Y
G
K
S
P
E
F
N
V
R
R
G
I
K
F
--
T
--
S
G
K
V
E
V
F
--
A
N
V
T
E
S
K
I
Q
D
I
K
I
-
Y
G
D
F
-
F
G
I
E
D
-
V
A
A
-
V
E
D
V
L
R
G
V
K
Y
E
R
E
D
V
L
K
A
L
K
T
I
D
I
T
R
-
Y
F
A
G
I
S
R
E
E
I
-----
30
HHSearch
89.62
32%
-70
* C4 *
3A7R
6
LPLA_ECOLI
A:
[3-332]
L
R
L
L
I
-
S
D
S
Y
D
P
W
F
N
L
A
V
E
E
C
I
F
R
Q
M
P
-
A
-
T
Q
R
V
L
F
L
-
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
-
A
G
K
P
-
E
---
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
--
G
V
S
A
E
----------
A
S
G
----------
R
N
D
L
V
V
K
T
VE
G
D
-
R
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
F
H
H
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
G
I
T
S
V
R
S
R
V
T
N
L
T
E
L
L
P
G
--
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
--
Y
---
G
-
E
R
--
V
E
A
--
E
-
I
I
S
P
NKT
P
D
-
L
P
N
F
A
E
T
F
A
R
----
Q
S
--
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
--
T
--
W
G
G
V
E
L
H
--
F
D
V
E
K
G
H
I
T
R
A
Q
V
-
F
T
D
S
-
L
N
P
A
P
-
L
E
A
-
L
A
G
R
L
Q
G
C
L
Y
R
A
D
M
L
Q
Q
E
C
E
A
L
L
V
D
F
-
P
E
Q
E
K
E
L
R
E
L
S
A
W
M
-
3
PsiBlast_PDB
86.15
33%
-66
- C4 -
3A7R
6
LPLA_ECOLI
A:
[12-309]
----------
D
P
W
F
N
L
A
V
E
E
C
I
F
R
Q
M
P
-
A
-
T
Q
R
V
L
F
L
-
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
-
A
----
G
K
P
E
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
--
G
V
S
A
E
----------
A
S
G
----------
R
N
D
L
V
V
K
T
VE
G
D
-
R
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
F
H
H
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
G
I
T
S
V
R
S
R
V
T
N
L
T
E
L
L
P
G
--
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
Y
G
E
---
R
-
V
E
--
A
----
E
-
I
I
S
P
---
N
K
-
T
P
D
L
P
N
F
A
E
T
F
---
A
R
Q
S
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
--
T
--
W
G
G
V
E
L
H
--
F
D
V
E
K
G
H
I
T
R
A
Q
V
-
F
T
D
S
-
L
N
P
A
P
-
L
E
A
-
L
A
G
R
L
Q
G
C
L
Y
R
A
D
M
L
Q
Q
-------------------------
6
PsiBlast_PDB
85.35
32%
-63
- C4 -
4TVW
1
LPLA_ECOLI
A:
[16-313]
----------
D
P
W
F
N
L
A
V
A
E
C
I
F
R
Q
M
P
-
A
-
T
Q
R
V
L
F
L
-
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
-
A
----
G
K
P
E
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
--
G
V
S
A
E
----------
A
S
G
----------
R
N
D
L
V
V
K
T
VE
G
D
-
R
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
A
H
G
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
G
I
T
S
V
R
S
R
V
T
N
L
T
E
L
L
P
G
--
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
Y
G
E
---
R
-
V
E
--
A
----
E
-
I
I
S
P
---
N
K
-
T
P
D
L
P
N
F
A
E
T
F
---
A
R
Q
S
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
--
T
--
W
G
G
V
E
L
H
--
F
D
V
E
K
G
H
I
T
R
A
Q
V
-
F
T
D
S
-
L
N
P
A
P
-
L
E
A
-
L
A
G
R
L
Q
G
C
L
Y
R
A
D
M
L
Q
Q
-------------------------
23
PsiBlast_CBE
84.94
32%
-65
- C4 -
4TVW
1
LPLA_ECOLI
D:
[16-313]
----------
D
P
W
F
N
L
A
V
A
E
C
I
F
R
Q
M
P
-
A
-
T
Q
R
V
L
F
L
-
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
-
A
----
G
K
P
E
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
--
G
V
S
A
E
----------
A
S
G
----------
R
N
D
L
V
V
KTVE
G
D
-
R
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
A
H
G
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
G
I
T
S
V
R
S
R
V
T
N
L
T
E
L
L
P
G
--
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
YG
E
---
R
-
V
E
--
A
----
E
-
I
I
S
P
---
N
K
-
T
P
D
L
P
N
F
A
E
T
F
---
A
R
QS
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
--
T
--
W
G
G
V
E
L
H
--
F
D
V
E
K
G
H
I
T
R
A
Q
V
-
F
T
D
S
-
L
N
P
A
P
-
L
E
A
-
L
A
G
R
L
Q
G
C
L
Y
R
A
D
M
L
Q
Q
-------------------------
25
PsiBlast_CBE
84.73
32%
-67
- C4 -
4TVW
1
LPLA_ECOLI
B:
[16-313]
----------
D
P
W
F
N
L
A
V
A
E
C
I
F
R
Q
M
P
-
A
-
T
Q
R
V
L
F
L
-
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
-
A
----
G
K
P
E
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
--
G
V
S
A
E
----------
A
S
G
----------
R
N
D
L
V
V
KTVE
G
D
-
R
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
A
H
G
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
G
I
T
S
V
R
S
R
V
T
N
L
T
E
L
L
P
G
--
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
YG
E
---
R
-
V
E
--
A
----
E
-
I
I
S
P
---
N
K
-
T
P
D
L
P
N
F
A
E
T
F
---
A
R
QS
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
--
T
--
W
G
G
V
E
L
H
--
F
D
V
E
K
G
H
I
T
R
A
Q
V
-
F
T
D
S
-
L
N
P
A
P
-
L
E
A
-
L
A
G
R
L
Q
G
C
L
Y
R
A
D
M
L
Q
Q
-------------------------
2
PsiBlast_PDB
84.36
33%
-66
- C4 -
3A7A
2
LPLA_ECOLI
A:
[12-309]
----------
D
P
W
F
N
L
A
V
E
E
C
I
F
R
Q
M
P
-
A
-
T
Q
R
V
L
F
L
-
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
-
A
----
G
K
P
E
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
--
G
V
S
A
E
----------
A
S
G
----------
R
N
D
L
V
V
K
T
VE
G
D
-
R
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
F
H
H
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
G
I
T
S
V
R
S
R
V
T
N
L
T
E
L
L
P
G
--
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
Y
G
E
---
R
-
V
E
--
A
----
E
-
I
I
S
P
---
N
K
-
T
P
D
L
P
N
F
A
E
T
F
---
A
R
Q
S
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
--
T
--
W
G
G
V
E
L
H
--
F
D
V
E
K
G
H
I
T
R
A
Q
V
-
F
T
D
S
-
L
N
P
A
P
-
L
E
A
-
L
A
G
R
L
Q
G
C
L
Y
R
A
D
M
L
Q
Q
-------------------------
21
PsiBlast_CBE
84.34
33%
-62
- C4 -
3A7A
2
LPLA_ECOLI
C:
[12-309]
----------
D
P
W
F
N
L
A
V
E
E
C
I
F
R
Q
M
P
-
A
-
T
Q
R
V
L
F
L
-
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
-
A
----
G
K
P
E
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
--
G
V
S
A
E
----------
A
S
G
----------
R
N
D
L
V
V
KTVE
G
D
-
R
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
F
H
H
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
G
I
T
S
V
R
S
R
V
T
N
L
T
E
L
L
P
G
--
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
YG
E
---
R
-
V
E
--
A
----
E
-
I
I
S
P
---
N
K
-
T
P
D
L
P
N
F
A
E
T
F
---
A
R
QS
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
--
T
--
W
G
G
V
E
L
H
--
F
D
V
E
K
G
H
I
T
R
A
Q
V
-
F
T
D
S
-
L
N
P
A
P
-
L
E
A
-
L
A
G
R
L
Q
G
C
L
Y
R
A
D
M
L
Q
Q
-------------------------
24
PsiBlast_CBE
84.27
32%
-66
- C4 -
4TVW
1
LPLA_ECOLI
C:
[16-313]
----------
D
P
W
F
N
L
A
V
A
E
C
I
F
R
Q
M
P
-
A
-
T
Q
R
V
L
F
L
-
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
-
A
----
G
K
P
E
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
--
G
V
S
A
E
----------
A
S
G
----------
R
N
D
L
V
V
KTVE
G
D
-
R
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
A
H
G
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
G
I
T
S
V
R
S
R
V
T
N
L
T
E
L
L
P
G
--
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
YG
E
---
R
-
V
E
--
A
----
E
-
I
I
S
P
---
N
K
-
T
P
D
L
P
N
F
A
E
T
F
---
A
R
QS
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
--
T
--
W
G
G
V
E
L
H
--
F
D
V
E
K
G
H
I
T
R
A
Q
V
-
F
T
D
S
-
L
N
P
A
P
-
L
E
A
-
L
A
G
R
L
Q
G
C
L
Y
R
A
D
M
L
Q
Q
-------------------------
22
PsiBlast_CBE
82.45
32%
-76
- C4 -
4TVY
2
LPLA_ECOLI
B:
[16-313]
----------
D
P
W
F
N
L
A
V
A
E
C
I
F
R
Q
M
P
-
A
-
T
Q
R
V
L
F
L
-
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
-
A
----
G
K
P
E
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
--
G
V
S
A
E
----------
A
S
G
----------
R
N
D
L
V
V
K
T
VE
G
D
-
R
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
A
H
G
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
----------------
R
V
T
N
L
T
E
L
L
P
G
--
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
Y
G
E
---
R
-
V
E
--
A
----
E
-
I
I
S
P
---
N
K
-
T
P
D
L
P
N
F
A
E
T
F
---
A
R
Q
S
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
--
T
--
W
G
G
V
E
L
H
--
F
D
V
E
K
G
H
I
T
R
A
Q
V
-
F
T
D
S
-
L
N
P
A
P
-
L
E
A
-
L
A
G
R
L
Q
G
C
L
Y
R
A
D
M
L
Q
Q
-------------------------
5
PsiBlast_PDB
81.05
33%
-69
- C4 -
1X2H
1
LPLA_ECOLI
A:
[12-309]
----------
D
P
W
F
N
L
A
V
E
E
C
I
F
R
Q
M
P
-
A
-
T
Q
R
V
L
F
L
-
W
R
N
A
D
T
V
V
I
G
R
A
Q
N
P
W
K
E
C
N
T
R
R
M
E
E
D
N
V
R
L
A
R
R
S
S
G
G
G
A
V
F
H
D
L
G
N
T
C
F
T
F
M
-
A
----
G
K
P
E
Y
D
K
T
I
S
T
S
I
V
L
N
A
L
N
A
L
--
G
V
S
A
E
----------
A
S
G
----------
R
N
D
L
V
V
K
T
VE
G
D
-
R
K
V
S
G
S
A
Y
R
E
T
K
D
R
G
F
H
H
G
T
L
L
L
N
A
D
L
S
R
L
A
N
Y
L
N
P
D
K
K
K
L
A
A
K
-------
R
V
T
N
L
T
E
L
L
P
G
--
I
T
H
E
Q
V
C
E
A
I
T
E
A
F
F
A
H
Y
G
E
---
R
-
V
E
--
A
----
E
-
I
I
S
P
---
N
K
-
T
P
D
L
P
N
F
A
E
T
F
---
A
R
Q
S
S
W
E
W
N
F
G
Q
A
P
A
F
S
H
L
L
D
E
R
F
--
T
--
W
G
G
V
E
L
H
--
F
D
V
E
K
G
H
I
T
R
A
Q
V
-
F
T
D
S
-
L
N
P
A
P
-
L
E
A
-
L
A
G
R
L
Q
G
C
L
Y
R
A
D
M
L
Q
Q
-------------------------
31
HHSearch
78.42
24%
-72
- C4 -
2E5A
5
LIPT_BOVIN
A:
[5-339]
G
L
I
L
Q
-
S
I
S
N
D
V
Y
H
N
L
A
V
E
D
W
I
H
D
H
M
N
-
L
E
G
K
P
V
L
F
L
-
W
R
N
S
P
T
V
V
I
G
R
H
Q
N
P
W
Q
E
C
N
L
N
L
M
R
E
E
G
V
K
L
A
R
R
R
S
G
G
G
T
V
Y
H
D
M
G
N
I
N
L
T
F
F
-
T
T
K
K
-
K
---
Y
D
R
M
E
N
L
K
L
V
V
R
A
L
K
A
V
H
P
H
L
D
V
Q
----------
A
T
K
----------
R
F
D
L
L
L
----
D
G
Q
F
K
I
S
G
T
A
S
K
I
G
R
N
A
A
Y
H
H
C
T
L
L
C
G
T
D
G
T
F
L
S
S
L
L
K
S
P
Y
Q
G
I
R
S
N
A
T
A
S
T
P
A
L
V
K
N
L
M
E
K
D
P
T
--
L
T
C
E
V
V
I
N
A
V
A
T
E
Y
A
T
S
--
H
---
Q
-
I
D
--
N
H
I
H
L
I
-
N
P
T
D
---
E
T
V
F
P
G
I
N
S
K
A
I
E
----
L
Q
--
T
W
E
W
I
Y
G
K
T
P
K
F
S
V
D
T
S
F
T
V
--
L
HS
H
V
E
I
K
V
F
--
I
D
V
K
N
G
R
I
E
V
C
N
I
-
E
A
P
D
H
W
L
P
L
E
I
C
D
Q
-
L
N
S
S
L
I
G
S
K
F
S
P
I
E
T
T
V
--------------
D
E
L
H
S
K
W
N
I
L
-
13
PsiBlast_PDB
76.60
29%
-68
- C4 -
3A7U
-
LIPT_BOVIN
A:
[18-334]
--------------
N
L
A
V
E
D
W
I
H
D
H
M
N
-
L
-
E
G
K
P
V
L
F
L
W
R
N
S
P
T
V
V
I
G
R
H
Q
N
P
W
Q
E
C
N
L
N
L
M
R
E
E
G
V
K
L
A
R
R
R
S
G
G
G
T
V
Y
H
D
M
G
N
I
N
L
T
F
F
-
T
T
K
K
-
K
---
Y
D
R
M
E
N
L
K
L
V
V
R
A
L
K
A
V
HP
H
L
D
V
Q
----------
A
T
K
----------
R
F
D
L
L
L
D---
G
Q
-
F
K
I
S
G
T
A
S
K
I
G
R
N
A
A
Y
H
H
C
T
L
L
C
G
T
D
G
T
F
L
S
S
L
L
K
------------------
K
N
L
M
E
--
K
D
P
T
L
T
C
E
V
V
I
N
A
V
A
T
E
Y
A
T
S
--
H
---
Q
-
I
D
--
N
----
H
I
H
L
I
N
---
P
T
-
D
E
T
V
F
P
G
I
N
S
K
A
I
E
L
Q
--
T
W
E
W
I
Y
G
K
T
P
K
F
S
V
D
T
S
F
T
V
LH
E
--
Q
S
H
V
E
I
K
V
F
I
D
V
K
N
G
R
I
E
V
C
N
I
E
A
P
D
H
-
W
L
P
L
E
-
I
C
D
Q
L
N
S
S
L
I
G
S
--
K
F
S
P
I
E
T
T
V
L
T
S
I
L
H
R
T
Y
P
G
D
D
E
L
H
S
------
8
PsiBlast_PDB
76.14
31%
-83
- C4 -
2ART
3
LPLAN_THEAC
A:
[16-255]
-------------
M
S
L
A
Y
D
E
A
I
Y
R
S
F
Q
Y
G
-
D
K
P
I
L
R
F
-
Y
R
H
D
R
S
V
I
I
G
Y
F
Q
V
A
E
E
E
V
D
L
D
Y
M
K
K
N
G
I
M
L
A
R
R
Y
T
G
G
G
A
V
Y
H
D
L
G
D
L
N
F
S
V
V
R
S
S
D
D
-
M
D
I
T
S
M
F
R
T
M
N
E
A
V
V
N
S
L
R
I
L
--
G
L
D
A
R
P
G
E
L
NDVSIP
V
N
K
----------
K
T
D
I
M
A
----
G
E
-
K
K
I
M
G
A
A
G
A
M
R
K
G
A
K
L
W
H
A
A
M
L
V
H
T
D
L
D
M
L
S
A
V
L
K
V
P
----------
S
T
R
E
R
V
A
N
V
T
D
F
V
D
---
V
S
I
D
E
V
R
N
A
L
I
R
G
-
F
S
E
--
T
L
HI
D
-
F
R
--
E
----
D
-
T
I
T
E
---
K
E
-
E
S
L
A
R
E
L
F
D
K
K
---
Y
S
--
T
E
E
W
N
M
G
--------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.80
31%
-79
- C4 -
2C7I
-
LPLAN_THEAC
A:
[16-255]
-------------
M
S
L
A
Y
D
E
A
I
Y
R
S
F
Q
Y
G
-
D
K
P
I
L
R
F
-
Y
R
H
D
R
S
V
I
I
G
Y
F
Q
V
A
E
E
E
V
D
L
D
Y
M
K
K
N
G
I
M
L
A
R
R
Y
T
G
G
G
A
V
Y
H
D
L
G
D
L
N
F
S
V
V
R
S
S
D
D
-
M
D
I
T
S
M
F
R
T
M
N
E
A
V
V
N
S
L
R
I
L
--
G
L
D
A
R
P
G
ELNDVSIP
V
N
K
----------
K
T
D
I
M
A
----
G
E
-
K
K
I
M
G
A
A
G
A
M
R
K
G
A
K
L
W
H
A
A
M
L
V
H
T
D
L
D
M
L
S
A
V
L
K
--------------
R
E
R
V
A
N
V
T
D
F
V
D
---
V
S
I
D
E
V
R
N
A
L
I
R
G
-
F
S
E
--
T
L
HI
D
-
F
R
--
E
----
D
-
T
I
T
E
---
K
E
-
E
S
L
A
R
E
L
F
D
K
K
---
Y
S
--
T
E
E
W
N
M
G
--------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
75.72
31%
-83
- C4 -
2C8M
1
LPLAN_THEAC
B:
[16-255]
-------------
M
S
L
A
Y
D
E
A
I
Y
R
S
F
Q
Y
G
-
D
K
P
I
L
R
F
-
Y
R
H
D
R
S
V
I
I
G
Y
F
Q
V
A
E
E
E
V
D
L
D
Y
M
K
K
N
G
I
M
L
A
R
R
Y
T
G
G
G
A
V
Y
H
D
L
G
D
L
N
F
S
V
V
R
S
S
D
D
-
M
D
I
T
S
M
F
R
T
M
N
E
A
V
V
N
S
L
R
I
L
--
G
L
D
A
R
P
G
ELNDVSIP
V
N
K
----------
K
T
D
I
M
A
----
G
E
-
K
K
I
M
G
A
A
G
A
M
R
K
G
A
K
L
W
H
A
A
M
L
V
H
T
D
L
D
M
L
S
A
V
L
------------
K
S
T
R
E
R
V
A
N
V
T
D
F
V
D
---
V
S
I
D
E
V
R
N
A
L
I
R
G
-
F
S
E
--
T
L
HI
D
-
F
R
--
E
----
D
-
T
I
T
E
---
K
E
-
E
S
L
A
R
E
L
F
D
K
K
---
Y
S
--
T
E
E
W
N
M
G
--------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
75.59
31%
-79
- C4 -
2C8M
1
LPLAN_THEAC
D:
[16-255]
-------------
M
S
L
A
Y
D
E
A
I
Y
R
S
F
Q
Y
G
-
D
K
P
I
L
R
F
-
Y
R
H
D
R
S
V
I
I
G
Y
F
Q
V
A
E
E
E
V
D
L
D
Y
M
K
K
N
G
I
M
L
A
R
R
Y
T
G
G
G
A
V
Y
H
D
L
G
D
L
N
F
S
V
V
R
S
S
D
D
-
M
D
I
T
S
M
F
R
T
M
N
E
A
V
V
N
S
L
R
I
L
--
G
L
D
A
R
PGELNDVSIP
V
N
K
----------
K
T
D
I
M
A
----
G
E
-
K
K
I
M
G
A
A
G
A
M
R
K
G
A
K
L
W
H
A
A
M
L
V
H
T
D
L
D
M
L
S
A
V
L
K
--------------
R
E
R
V
A
N
V
T
D
F
V
D
---
V
S
I
D
E
V
R
N
A
L
I
R
G
-
F
S
E
--
T
LHI
D
-
F
R
--
E
----
D
-
T
I
T
E
---
K
E
-
E
S
L
A
R
E
L
F
D
K
K
---
Y
S
--
T
E
E
W
N
M
G
--------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
75.33
31%
-78
- C4 -
2ARU
2
LPLAN_THEAC
A:
[16-255]
-------------
M
S
L
A
Y
D
E
A
I
Y
R
S
F
Q
Y
G
-
D
K
P
I
L
R
F
-
Y
R
H
D
R
S
V
I
I
G
Y
F
Q
V
A
E
E
E
V
D
L
D
Y
M
K
K
N
G
I
M
L
A
R
R
Y
T
G
G
G
A
V
Y
H
D
L
G
D
L
N
F
S
V
V
R
S
S
D
D
-
M
D
I
T
S
M
F
R
T
M
N
E
A
V
V
N
S
L
R
I
L
--
G
L
D
A
R
P
G
E
L
NDVSIP
V
N
K
----------
K
T
D
I
M
A
----
G
E
-
K
K
I
M
G
A
A
G
A
M
R
K
G
A
K
L
W
H
A
A
M
L
V
H
T
D
L
D
M
L
S
A
V
L
K
V
P
----------
S
T
R
E
R
V
A
N
V
T
D
F
V
D
---
V
S
I
D
E
V
R
N
A
L
I
R
G
-
F
S
E
--
T
L
HI
D
-
F
R
--
E
----
D
-
T
I
T
E
---
K
E
-
E
S
L
A
R
E
L
F
D
K
K
---
Y
S
--
T
E
E
W
N
M
G
--------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
74.90
31%
-79
- C4 -
2C8M
1
LPLAN_THEAC
C:
[16-255]
-------------
M
S
L
A
Y
D
E
A
I
Y
R
S
F
Q
Y
G
-
D
K
P
I
L
R
F
-
Y
R
H
D
R
S
V
I
I
G
Y
F
Q
V
A
E
E
E
V
D
L
D
Y
M
K
K
N
G
I
M
L
A
R
R
Y
T
G
G
G
A
V
Y
H
D
L
G
D
L
N
F
S
V
V
R
S
S
D
D
-
M
D
I
T
S
M
F
R
T
M
N
E
A
V
V
N
S
L
R
I
L
--
G
L
D
A
R
P
G
ELNDVSIP
V
N
K
----------
K
T
D
I
M
A
----
G
E
-
K
K
I
M
G
A
A
G
A
M
R
K
G
A
K
L
W
H
A
A
M
L
V
H
T
D
L
D
M
L
S
A
V
L
------------
K
S
T
R
E
R
V
A
N
V
T
D
F
V
D
---
V
S
I
D
E
V
R
N
A
L
I
R
G
-
F
S
E
--
T
LHI
D
-
F
R
--
E
----
D
-
T
I
T
E
---
K
E
-
E
S
L
A
R
E
L
F
D
K
K
---
Y
S
--
T
E
E
W
N
M
G
--------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.77
31%
-77
- C4 -
3R07
3
LPLAN_THEAC
A:
[39-278]
-------------
M
S
L
A
Y
D
E
A
I
Y
R
S
F
Q
Y
G
-
D
K
P
I
L
R
F
-
Y
R
H
D
R
S
V
I
I
G
Y
F
Q
V
A
E
E
E
V
D
L
D
Y
M
K
K
N
G
I
M
L
A
R
R
Y
T
G
G
G
A
V
Y
H
D
L
G
D
L
N
F
S
V
V
R
S
S
D
D
-
M
D
I
T
S
M
F
R
T
M
N
E
A
V
V
N
S
L
R
I
L
--
G
L
D
A
R
P
G
EL
N
D
V
S
I
P
V
----------------------
G
E
-
K
K
I
M
G
A
A
G
A
M
R
K
G
A
K
L
W
H
A
A
M
L
V
H
T
D
L
D
M
L
S
A
V
L
K
V
P
D
E
K
F
R
D
K
I
A
K
S
T
R
E
R
V
A
N
V
T
D
F
V
D
---
V
S
I
D
E
V
R
N
A
L
I
R
G
-
F
S
E
--
T
L
HI
D
-
F
R
--
E
----
D
-
T
I
T
E
---
K
E
-
E
S
L
A
R
E
L
F
D
K
K
---
Y
S
--
T
E
E
W
N
M
G
--------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.19
31%
-84
- C4 -
2C8M
1
LPLAN_THEAC
A:
[16-255]
-------------
M
S
L
A
Y
D
E
A
I
Y
R
S
F
Q
Y
G
-
D
K
P
I
L
R
F
-
Y
R
H
D
R
S
V
I
I
G
Y
F
Q
V
A
E
E
E
V
D
L
D
Y
M
K
K
N
G
I
M
L
A
R
R
Y
T
G
G
G
A
V
Y
H
D
L
G
D
L
N
F
S
V
V
R
S
S
D
D
-
M
D
I
T
S
M
F
R
T
M
N
E
A
V
V
N
S
L
R
I
L
--
G
L
D
A
R
P
G
ELNDVSIP
V
N
K
----------
K
T
D
I
M
A
----
G
E
-
K
K
I
M
G
A
A
G
A
M
R
K
G
A
K
L
W
H
A
A
M
L
V
H
T
D
L
D
M
L
S
A
V
L
K
---------------
E
R
V
A
N
V
T
D
F
V
D
---
V
S
I
D
E
V
R
N
A
L
I
R
G
-
F
S
E
--
T
L
H
I
D
-
F
R
--
E
----
D
-
T
I
T
E
---
K
E
-
E
S
L
A
R
E
L
F
D
K
K
---
Y
S
--
T
E
E
W
N
M
G
--------------------------------------------------------------------------------------------------
32
HHSearch
73.55
30%
-76
- C4 -
2C8M
1
LPLAN_THEAC
A:
[4-256]
R
L
L
L
L
-
E
T
P
G
N
T
R
M
S
L
A
Y
D
E
A
I
Y
R
S
F
Q
-
Y
G
D
K
P
I
L
R
F
-
Y
R
H
D
R
S
V
I
I
G
Y
F
Q
V
A
E
E
E
V
D
L
D
Y
M
K
K
N
G
I
M
L
A
R
R
Y
T
G
G
G
A
V
Y
H
D
L
G
D
L
N
F
S
V
V
-
R
S
S
D
D
M
D
I
T
S
M
F
R
T
M
N
E
A
V
V
N
S
L
R
I
L
--
G
L
D
A
R
----------
P
G
E
LNDVSIPVNK
K
T
D
I
M
A
----
G
E
-
K
K
I
M
G
A
A
G
A
M
R
K
G
A
K
L
W
H
A
A
M
L
V
H
T
D
L
D
M
L
S
A
V
L
K
---------------
E
R
V
A
N
V
T
D
F
V
--
D
-
V
S
I
D
E
V
R
N
A
L
I
R
G
F
S
E
T
--
L
---
H
-
I
D
F
R
E
----
D
-
T
I
T
E
---
K
E
-
E
S
L
A
R
E
L
F
D
K
K
---
Y
S
--
T
E
E
W
N
M
G
L
-------------------------------------------------------------------------------------------------