@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1012: (2016-03-21 )
MKNLRNRSFLTLLDFSRQEVEFLLTLSEDLKRAKYIGTEKPMLKNKNIALLFEKDSTRTRCAFEVAAHDQGANVTYLGPTGSQMGKKETTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEVLKKDYADINFTYVGDGRNNVANALMQGAAIMGMNFHLVCPKELNPTDELLNRCKNIAAENGGNILITDDIDQGVKGSDVIYTDVWVSMGEPDEVWKERLELLKPYQVNKEMMDKTGNPNVIFEHCLPSFHNADTKIGQQIFEKYGIREMEVTDEVFESKASVVFQEAENRMHTIKAVMVATLGEF
Atome Classification :
(39 SA)
.........10........20........30-....-....40........50........60........70........80........90........100.......110.......120.......130.......140.......150.........160.......170.......180.......190.......200.......210.......220.......230.......240.......250-.......260.....--..270.......280.......290.--..-....300.......310.......320.......330.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKNLRNR
S
F
L
T
LLDF
S
R
Q
E
V
E
F
L
L
T
L
S
E
D
L
K
-
R
A
KY-IGTEKPMLKNK
N
I
A
L
L
F
EKDSTR
T
R
C
A
F
E
V
AAHDQGA
N
V
T
Y
LGPTGSQMGKKET
T
K
D
T
A
R
V
L
G
G
MYDGIEYRGF
S
Q
R
T
V
E
T
L
A
E
YSGVPVWNGLTDED
H
P
T
Q
V
L
A
D
F
L
T
A
K
E
V
L
K
--
K
DYAD
I
N
F
T
Y
VGDGR
N
N
V
A
N
A
L
M
QG
A
A
I
MG
M
N
F
H
L
V
CPKELN
P
T
D
E
L
L
N
R
C
K
N
I
A
AENGG
N
I
L
I
TDDIDQGVKGS
D
V
I
Y
T
D
V
W
VSMG
E
P
D
E
V
W
K
E
R
L
E
LLKP-YQV
N
K
E
M
M
DKTGNP
N
--
V
I
F
E
H
CL
P
S
FHN
A
D
T
K
I
G
Q
Q
I
F
E
K
YG--IR-EM
E
V
T
D
E
V
F
E
S
K
A
S
V
V
F
Q
E
A
EN
R
M
H
T
I
K
A
V
M
V
A
TLGEF
1
PsiBlast_PDB
98.69
64%
-94
- C5 -
3UPD
-
OTC_VIBVU
A:
[4-333]
--
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G-
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
T
G
N
P
N
--
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
--
27
PsiBlast_CBE
98.29
64%
-90
- C5 -
4JFR
3
OTC_VIBVU
C:
[28-357]
--
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G-
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
T
G
N
P
N
--
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
--
21
PsiBlast_CBE
97.87
64%
-93
- C5 -
4KWT
3
OTC_VIBVU
C:
[28-357]
--
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G-
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
------
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
T
G
N
P
N
--
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
--
25
PsiBlast_CBE
97.46
64%
-91
- C5 -
4JHX
1
OTC_VIBVU
C:
[28-357]
--
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G-
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
-------
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
T
G
N
P
N
--
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
--
28
PsiBlast_CBE
97.16
64%
-88
- C5 -
4JFR
3
OTC_VIBVU
B:
[28-357]
--
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G-
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
T
G
N
P
N
--
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
--
24
PsiBlast_CBE
97.02
64%
-89
- C5 -
4JQO
6
OTC_VIBVU
B:
[28-357]
--
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G-
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
T
G
N
P
N
--
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
--
4
PsiBlast_PDB
96.98
64%
-87
- C5 -
4JHX
3
OTC_VIBVU
A:
[28-357]
--
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G-
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
T
G
N
P
N
--
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
--
22
PsiBlast_CBE
96.95
64%
-90
- C5 -
4KWT
1
OTC_VIBVU
B:
[28-357]
--
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G-
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
--------
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
T
G
N
P
N
--
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
--
3
PsiBlast_PDB
96.95
64%
-88
- C5 -
4JFR
2
OTC_VIBVU
A:
[28-357]
--
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G-
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
T
G
N
P
N
--
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
--
2
PsiBlast_PDB
96.68
64%
-87
- C5 -
4H31
14
OTC_VIBVU
A:
[28-357]
--
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G-
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
T
G
N
P
N
--
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
--
30
PsiBlast_CBE
96.52
64%
-85
- C5 -
4H31
12
OTC_VIBVU
B:
[28-357]
--
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G-
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
T
G
N
P
N
--
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
--
5
PsiBlast_PDB
96.42
64%
-88
- C5 -
4JQO
8
OTC_VIBVU
A:
[28-357]
--
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G-
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
T
G
N
P
N
--
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
--
23
PsiBlast_CBE
96.31
64%
-88
- C5 -
4JQO
6
OTC_VIBVU
C:
[28-357]
--
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G-
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
T
G
N
P
N
--
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
--
29
PsiBlast_CBE
96.19
64%
-87
- C5 -
4H31
8
OTC_VIBVU
C:
[28-357]
--
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G-
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
T
G
N
P
N
--
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
--
26
PsiBlast_CBE
96.19
64%
-91
- C5 -
4JHX
3
OTC_VIBVU
B:
[28-357]
--
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G-
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
--------
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
T
G
N
P
N
--
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
--
112
HHSearch
92.66
58%
-83
- C5 -
1DXH
3
OTCC_PSEAE
A:
[1-334]
A
F
N
M
H
N
R
N
L
L
S
L
M
H
H
S
T
R
E
L
R
Y
L
L
D
L
S
R
D
L
K
-
R
A
K
Y
-
T
G
T
E
Q
Q
H
L
K
R
K
N
I
A
L
I
F
E
K
T
S
T
R
T
R
C
A
F
E
V
A
A
Y
D
Q
G
A
N
V
T
Y
I
D
P
N
S
S
Q
I
G
H
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
A
I
E
Y
R
G
F
K
Q
E
I
V
E
E
L
A
K
F
A
G
V
P
V
F
N
G
L
T
D
E
Y
H
P
T
Q
M
L
A
D
V
L
T
M
R
E
H
S
D
--
K
P
L
H
D
I
S
Y
A
Y
L
G
D
A
R
N
N
M
G
N
S
L
L
L
I
G
A
K
L
G
M
D
V
R
I
A
A
P
K
A
L
W
P
H
D
E
F
V
A
Q
C
K
K
F
A
E
E
S
G
A
K
L
T
L
T
E
D
P
K
E
A
V
K
G
V
D
F
V
H
T
D
V
W
V
S
M
G
E
P
V
E
A
W
G
E
R
I
K
E
L
L
P
-
Y
Q
V
N
M
E
I
M
K
A
T
G
N
P
R
--
A
K
F
M
H
C
L
P
A
F
H
N
S
E
T
K
V
G
K
Q
I
A
E
Q
Y
P
NL
A
N
-
G
I
E
V
T
E
D
V
F
E
S
P
Y
N
I
A
F
E
Q
A
E
N
R
M
H
T
I
K
A
I
L
V
S
T
L
A
D
-
9
PsiBlast_PDB
92.49
57%
-84
- C5 -
1DXH
3
OTCC_PSEAE
A:
[3-335]
--
N
M
H
N
R
N
L
L
S
L
M
H
H
S
T
R
E
L
R
Y
L
L
D
L
S
R
D
L
K
-
R
A
K
Y
-
T
G
T
E
Q
Q
H
L
K
R
K
N
I
A
L
I
F
E
K
T
S
T
R
T
R
C
A
F
E
V
A
A
Y
D
Q
G
A
N
V
T
Y
I
D
P
N
S
S
Q
I
G
H
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
A
I
E
Y
R
G
F
K
Q
E
I
V
E
E
L
A
K
F
A
G
V
P
V
F
N
G
L
T
D
E
Y
H
P
T
Q
M
L
A
D
V
L
T
M
R
E
H
S
D
--
K
P
L
H
D
I
S
Y
A
Y
L
G
D
A
R
N
N
M
G
N
S
L
L
L
I
G
A
K
L
G
M
D
V
R
I
A
A
P
K
A
L
W
P
H
D
E
F
V
A
Q
C
K
K
F
A
E
E
S
G
A
K
L
T
L
T
E
D
P
K
E
A
V
K
G
V
D
F
V
H
T
D
V
W
V
S
M
G
E
P
V
E
A
W
G
E
R
I
K
E
L
L
P
-
Y
Q
V
N
M
E
I
M
K
A
T
G
N
P
R
--
A
K
F
M
H
C
L
P
A
F
H
N
S
E
T
K
V
G
K
Q
I
A
E
Q
Y
P
NL
A
N
-
G
I
E
V
T
E
D
V
F
E
S
P
Y
N
I
A
F
E
Q
A
E
N
R
M
H
T
I
K
A
I
L
V
S
T
L
A
D
I
11
PsiBlast_PDB
92.48
58%
-88
- C5 -
2W37
1
OTCC_LACHI
A:
[26-352]
---
F
Q
G
R
S
V
L
A
E
K
D
F
S
A
A
E
L
E
Y
L
I
D
F
G
L
H
L
K
-
A
L
K
K
-
A
G
I
P
H
H
Y
L
E
G
K
N
I
A
L
L
F
E
K
S
S
T
R
T
R
S
A
F
T
T
A
S
I
D
L
G
A
H
P
E
Y
L
G
Q
N
D
I
Q
L
G
K
K
E
S
T
S
D
T
A
K
V
L
G
S
M
F
D
G
I
E
F
R
G
F
K
Q
S
D
A
E
I
L
A
R
D
S
G
V
P
V
W
N
G
L
T
D
E
W
H
P
T
Q
M
L
A
D
F
M
T
V
K
E
N
F
G
--
K
-
L
Q
G
L
T
L
T
F
M
G
D
G
R
N
N
V
A
N
S
L
L
V
T
G
A
I
L
G
V
N
I
H
I
V
A
P
K
A
L
F
P
T
E
E
T
Q
N
I
A
K
G
F
A
E
K
S
G
A
K
L
V
I
T
D
D
L
D
E
G
L
K
G
S
N
V
V
Y
T
D
V
W
V
S
M
G
E
S
N
--
W
E
E
R
V
K
E
L
T
P
-
Y
Q
V
N
M
E
A
M
K
K
T
G
T
P
D
DQ
L
I
F
M
H
C
L
P
A
F
H
N
T
D
T
Q
Y
G
K
E
I
K
E
K
Y
G
--
I
T
-
E
M
E
V
T
D
E
V
F
T
S
K
Y
A
R
Q
F
E
E
A
E
N
R
M
H
S
I
K
A
M
M
A
A
T
L
G
--
34
PsiBlast_CBE
92.46
59%
-87
- C5 -
2OTC
2
OTC1_ECOLI
H:
[5-331]
-----
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
-
S
G
K
E
E
A
K
L
T
G
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P
G-
K
A
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
E
K
W
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
T
G
N
P
E
--
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
--
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
---
41
PsiBlast_CBE
92.43
58%
-85
- C5 -
2W37
1
OTCC_LACHI
C:
[26-352]
---
F
Q
G
R
S
V
L
A
E
K
D
F
S
A
A
E
L
E
Y
L
I
D
F
G
L
H
L
K
-
A
L
K
K
-
A
G
I
P
H
H
Y
L
E
G
K
N
I
A
L
L
F
E
K
S
S
T
R
T
R
S
A
F
T
T
A
S
I
D
L
G
A
H
P
E
Y
L
G
Q
N
D
I
Q
L
G
K
K
E
S
T
S
D
T
A
K
V
L
G
S
M
F
D
G
I
E
F
R
G
F
K
Q
S
D
A
E
I
L
A
R
D
S
G
V
P
V
W
N
G
L
T
D
E
W
H
P
T
Q
M
L
A
D
F
M
T
V
K
E
N
F
G
--
K
-
L
Q
G
L
T
L
T
F
M
G
D
G
R
N
N
V
A
N
S
L
L
V
T
G
A
I
L
G
V
N
I
H
I
V
A
P
K
A
L
F
P
T
E
E
T
Q
N
I
A
K
G
F
A
E
K
S
G
A
K
L
V
I
T
D
D
L
D
E
G
L
K
G
S
N
V
V
Y
T
D
V
W
V
S
M
G
E
S
N
--
W
E
E
R
V
K
E
L
T
P
-
Y
Q
V
N
M
E
A
M
K
K
T
G
T
P
D
DQ
L
I
F
M
H
C
L
P
A
F
H
N
T
D
T
Q
Y
G
K
E
I
K
E
K
Y
G
--
I
T
-
E
M
E
V
T
D
E
V
F
T
S
K
Y
A
R
Q
F
E
E
A
E
N
R
M
H
S
I
K
A
M
M
A
A
T
L
G
--
32
PsiBlast_CBE
92.07
59%
-83
- C5 -
1DUV
2
OTC1_ECOLI
H:
[5-331]
-----
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
-
S
G
K
E
E
A
K
L
T
G
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P
G-
K
A
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
E
K
W
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
T
G
N
P
E
--
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
--
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
---
31
PsiBlast_CBE
91.93
59%
-82
- C5 -
1DUV
2
OTC1_ECOLI
I:
[5-331]
-----
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
-
S
G
K
E
E
A
K
L
T
G
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P
G-
K
A
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
E
K
W
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
T
G
N
P
E
--
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
--
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
---
7
PsiBlast_PDB
91.32
59%
-85
- C5 -
1DUV
3
OTC1_ECOLI
G:
[5-331]
-----
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
-
S
G
K
E
E
A
K
L
T
G
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P
G-
K
A
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
E
K
W
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
T
G
N
P
E
--
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
--
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
---
48
PsiBlast_CBE
78.39
36%
-82
- C5 -
1EP9
1
OTC_HUMAN
A:
[3-312]
--
Q
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
-
K
G
E
Y
L
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
E
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
-
K
V
A
A
S
D
--
W
T
F
L
H
C
L
P
R
--------------------
K
-
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
115
HHSearch
78.33
38%
-81
- C5 -
1OTH
1
OTC_HUMAN
A:
[2-312]
-
V
Q
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
-
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
E
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
V
A
-
A
S
D
--
W
T
F
L
H
C
L
P
R
K
---------------------
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
49
PsiBlast_CBE
78.15
36%
-81
- C5 -
1C9Y
2
OTC_HUMAN
A:
[3-312]
--
Q
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
-
K
G
E
Y
L
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
E
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
-
K
V
A
A
S
D
--
W
T
F
L
H
C
L
P
R
--------------------
K
-
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
45
PsiBlast_CBE
78.04
36%
-81
- C5 -
1OTH
1
OTC_HUMAN
A:
[3-312]
--
Q
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
-
K
G
E
Y
L
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
E
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
-
K
V
A
A
S
D
--
W
T
F
L
H
C
L
P
R
--------------------
K
-
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
46
PsiBlast_CBE
78.03
36%
-85
- C5 -
1FVO
1
OTC_HUMAN
B:
[3-312]
--
Q
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
-
K
G
E
Y
L
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
E
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
-
K
V
A
A
S
D
--
W
T
F
L
H
C
L
P
R
--------------------
K
-
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
63
PsiBlast_CBE
77.33
35%
-77
- C5 -
4A8T
3
PTC_ENTFA
A:
[25-334]
------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
-
E
A
I
K
-
N
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
-
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
EG
K
K
L
E
D
C
K
V
V
F
V
G
D
A
-
T
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
S
-
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
R
A
G
-
A
N
--
C
K
F
M
H
C
L
P
A
-------------------
T
R
-
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
47
PsiBlast_CBE
77.32
36%
-80
- C5 -
1FVO
1
OTC_HUMAN
A:
[3-312]
--
Q
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
-
K
G
E
Y
L
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
E
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
-
K
V
A
A
S
D
--
W
T
F
L
H
C
L
P
R
--------------------
K
-
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
70
PsiBlast_CBE
75.43
35%
-76
- C5 -
4A8H
6
PTC_ENTFA
B:
[3-312]
------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
-
E
A
I
K
-
N
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
EG
K
K
L
E
D
C
K
V
V
F
V
G
D
A
-
T
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
-
S
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
R
A
G
-
A
N
--
C
K
F
M
H
C
L
P
A
-------------------
T
R
-
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
19
PsiBlast_PDB
74.87
37%
-79
- C5 -
4NF2
5
OTC_BACAN
A:
[33-331]
---
L
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-
K
N
K
-----
Q
E
P
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
-
T
--
N
T
F
K
G
I
K
L
A
Y
V
G
D
G
-
N
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
E
G
E
--
E
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
-
K
H
A
K
Q
T
--
Y
H
F
L
H
C
L
P
A
H
-------------------
R
-
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
-----
71
PsiBlast_CBE
74.61
35%
-74
- C5 -
4A8H
6
PTC_ENTFA
A:
[3-312]
------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
-
E
A
I
K
-
N
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
EG
K
K
L
E
D
C
K
V
V
F
V
G
D
A
-
T
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
-
S
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
R
A
G
-
A
N
--
C
K
F
M
H
C
L
P
A
-------------------
T
R
-
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
43
PsiBlast_CBE
74.43
37%
-81
- C5 -
4NF2
4
OTC_BACAN
C:
[33-331]
---
L
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-
K
N
K
-----
Q
E
P
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
-
T
--
N
T
F
K
G
I
K
L
A
Y
V
G
D
G
-
N
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
E
G
E
--
E
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
-
K
H
A
K
Q
T
--
Y
H
F
L
H
C
L
P
A
H
-------------------
R
-
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
-----
44
PsiBlast_CBE
73.62
37%
-77
- C5 -
4NF2
5
OTC_BACAN
B:
[33-331]
---
L
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-
K
N
K
-----
Q
E
P
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
-
T
--
N
T
F
K
G
I
K
L
A
Y
V
G
D
G
-
N
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
E
G
E
--
E
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
-
K
H
A
K
Q
T
--
Y
H
F
L
H
C
L
P
A
H
-------------------
R
-
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
-----
86
PsiBlast_CBE
70.84
33%
-71
- C5 -
2I6U
5
OTC_MYCTU
C:
[3-304]
------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
-
K
D
P
V
---
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
-
R
K
--
G
A
L
R
G
L
R
L
S
Y
F
G
D
G
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
E
N
D
-
G
L
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
-
A
L
A
D
S
D
--
A
I
V
L
H
C
L
P
A
-
H
R
G
D
-------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
---
118
HHSearch
70.39
34%
-73
- C5 -
2I6U
5
OTC_MYCTU
A:
[2-306]
-----
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
-
K
D
P
V
-
S
--
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
---
G
A
L
R
G
L
R
L
S
Y
F
G
D
G
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
E
N
D
G
-
L
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
L
A
-
D
S
D
--
A
I
V
L
H
C
L
P
A
H
-------------------
R
-
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
-
87
PsiBlast_CBE
68.89
33%
-68
- C5 -
2I6U
5
OTC_MYCTU
B:
[3-304]
------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
-
K
D
P
V
---
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
-
R
K
--
G
A
L
R
G
L
R
L
S
Y
F
G
D
G
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
E
N
D
-
G
L
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
-
A
L
A
D
S
D
--
A
I
V
L
H
C
L
P
A
-
H
R
G
D
-------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
---
88
PsiBlast_CBE
68.32
33%
-69
- C5 -
2I6U
5
OTC_MYCTU
A:
[3-304]
------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
-
K
D
P
V
---
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
-
R
K
--
G
A
L
R
G
L
R
L
S
Y
F
G
D
G
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
E
N
D
-
G
L
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
-
A
L
A
D
S
D
--
A
I
V
L
H
C
L
P
A
-
H
R
G
D
-------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
---