@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1227: (2016-03-23 )
MTHLFEGVGVALTTPFTNNKVNLEALKAHVNFLLENNAQAIIVNGTTAESPTLTTDEKERILKTVIDLVDKRVPVIAGTGTNDTEKSIQASFQAKALGADAIMLITPYYNKTNQRGLVKHFEAITDAVKLPVVLYNVPSRTNMTIEPETVEILSQHPYIVALKDATNDFEYLEEVKKRIDTNSFALYSGNDDNVVEYYQRGGQGVISVIANVIPKEFQALYDAQQSGLDIQDQFKPIGTLLSALSVDINPIPIKALTSYLEFGNYELRLPLVSLEDTDTKVLREAYDTFKAGENE
Atome Classification :
(43 SA)
.........10....-.-.-..-20........30........40........50........60........70........80........90........100..-.....110.......120.......130.......140.......-150...-.....160.....--..170.....--..180-........190.......200.......210......-----.220.-----.-----...-----.-----.230..-------.....240.......250.......260-.......270.......280.......290...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
H
L
FEGV
G
V
A
L
TTP-F-T-NN-K
V
N
L
E
A
L
K
A
H
V
N
F
LLENNA
Q
A
I
I
V
NGTTAESPTLT
T
D
E
K
E
R
I
L
K
T
V
I
D
L
V
DKRV
P
V
I
A
GTGTN
D
T
E
K
S
I
Q
A
S
F
Q
AKALGA
D
A
I
M
L
-
I
TPYYNKTN
Q
R
G
L
V
K
H
F
E
A
I
T
D
A
VKL
P
V
V
L
Y
NVPSRTN
M
T
IE
P
E
T
-
V
-
E
I
L
S-QH
P
Y
I
V
A
LKDATN--
D
F
E
Y
L
E
E
V
K
K
--RIDT--N
S
F
A
L
YSGND
D
N
V
V
E
Y
Y
Q
RGG
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
-----
A
L
Y
D
A
-----
Q
-----QSG-----L-----
D
I
Q
D
QF-------
K
P
I
G
T
L
L
S
A
L
SVDINPI
P
I
K
A
L
T
S
Y
L
E
F-G
N
Y
E
L
R
L
P
L
V
SLED
T
D
T
K
V
L
R
E
A
Y
D
T
FKAGENE
24
PsiBlast_CBE
98.77
98%
-108
- C3 -
3DAQ
5
DAPA_STAAR
C:
[1-292]
-
T
H
L
F
E
G
V
G
V
A
L
T
T
P
-
F
-
T
-
N
N
-
K
V
N
L
E
A
L
K
A
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
L
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
-
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
-
V
-
E
I
L
S
-
Q
H
P
Y
I
V
A
L
K
D
A
T
N
--
D
F
E
Y
L
E
E
V
K
K
--
R
I
D
T
--
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
-----
A
L
Y
D
A
-----
Q
-----
Q
S
G
-----
L
-----
D
I
Q
D
Q
F
-------
K
P
I
G
T
L
L
S
A
L
S
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
L
R
L
P
L
V
S
L
E
D
T
D
T
K
V
L
R
E
A
Y
D
T
F
K
A
G
E
--
1
PsiBlast_PDB
98.66
97%
-112
- C3 -
3DI0
1
DAPA_STAAC
A:
[2-292]
-
T
H
L
F
E
G
V
G
V
A
L
T
T
P
-
F
-
T
-
N
N
-
K
V
N
I
E
A
L
K
T
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
R
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
-
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
-
V
-
E
I
L
S
-
Q
H
P
Y
I
V
A
L
K
D
A
T
N
--
D
F
E
Y
L
E
E
V
K
K
--
R
I
D
T
--
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
-----
A
L
Y
D
A
-----
Q
-----
Q
S
G
-----
L
-----
D
I
Q
D
Q
F
-------
K
P
I
G
T
L
L
S
A
L
S
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
L
R
L
P
L
V
S
L
E
D
T
D
T
K
V
L
R
E
T
Y
D
T
F
K
A
G
---
116
HHSearch
98.47
99%
-109
- C3 -
3DAQ
4
DAPA_STAAR
A:
[1-291]
-
T
H
L
F
E
G
V
G
V
A
L
T
T
P
-
F
-
T
-
N
N
-
K
V
N
L
E
A
L
K
A
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
L
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
-
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
-
V
-
E
I
L
S
-
Q
H
P
Y
I
V
A
L
K
D
A
T
N
--
D
F
E
Y
L
E
E
V
K
K
--
R
I
D
T
--
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
-----
A
L
Y
D
A
-----
Q
-----
Q
S
G
-----
L
-----
D
I
Q
D
Q
F
-------
K
P
I
G
T
L
L
S
A
L
S
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
L
R
L
P
L
V
S
L
E
D
T
D
T
K
V
L
R
E
A
Y
D
T
F
K
A
G
---
3
PsiBlast_PDB
98.25
98%
-108
- C3 -
3DAQ
4
DAPA_STAAR
A:
[1-292]
-
T
H
L
F
E
G
V
G
V
A
L
T
T
P
-
F
-
T
-
N
N
-
K
V
N
L
E
A
L
K
A
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
L
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
-
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
-
V
-
E
I
L
S
-
Q
H
P
Y
I
V
A
L
K
D
A
T
N
--
D
F
E
Y
L
E
E
V
K
K
--
R
I
D
T
--
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
-----
A
L
Y
D
A
-----
Q
-----
Q
S
G
-----
L
-----
D
I
Q
D
Q
F
-------
K
P
I
G
T
L
L
S
A
L
S
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
L
R
L
P
L
V
S
L
E
D
T
D
T
K
V
L
R
E
A
Y
D
T
F
K
A
G
E
--
25
PsiBlast_CBE
97.98
98%
-108
- C3 -
3DAQ
5
DAPA_STAAR
B:
[1-292]
-
T
H
L
F
E
G
V
G
V
A
L
T
T
P
-
F
-
T
-
N
N
-
K
V
N
L
E
A
L
K
A
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
L
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
-
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
-
V
-
E
I
L
S
-
Q
H
P
Y
I
V
A
L
K
D
A
T
N
--
D
F
E
Y
L
E
E
V
K
K
--
R
I
D
T
--
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
-----
A
L
Y
D
A
-----
Q
-----
Q
S
G
-----
L
-----
D
I
Q
D
Q
F
-------
K
P
I
G
T
L
L
S
A
L
S
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
L
R
L
P
L
V
S
L
E
D
T
D
T
K
V
L
R
E
A
Y
D
T
F
K
A
G
E
--
22
PsiBlast_CBE
97.88
97%
-110
- C3 -
3DI0
1
DAPA_STAAC
B:
[2-293]
-
T
H
L
F
E
G
V
G
V
A
L
T
T
P
-
F
-
T
-
N
N
-
K
V
N
I
E
A
L
K
T
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
R
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
-
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
-
V
-
E
I
L
S
-
Q
H
P
Y
I
V
A
L
K
D
A
T
N
--
D
F
E
Y
L
E
E
V
K
K
--
R
I
D
T
--
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
-----
A
L
Y
D
A
-----
Q
-----
Q
S
G
-----
L
-----
D
I
Q
D
Q
F
-------
K
P
I
G
T
L
L
S
A
L
S
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
L
R
L
P
L
V
S
L
E
D
T
D
T
K
V
L
R
E
T
Y
D
T
F
K
A
G
E
--
21
PsiBlast_CBE
97.50
97%
-107
- C3 -
3DI1
1
DAPA_STAAC
B:
[1-291]
M
T
H
L
F
E
G
V
G
V
A
L
T
T
P
-
F
-
T
-
N
N
-
K
V
N
I
E
A
L
K
T
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
R
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
-
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
-
V
-
E
I
L
S
-
Q
H
P
Y
I
V
A
L
K
D
A
T
N
--
D
F
E
Y
L
E
E
V
K
K
--
R
I
D
T
--
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
-----
A
L
Y
D
A
-----
Q
-----
Q
S
G
-----
L
-----
D
I
Q
D
Q
F
-------
K
P
I
G
T
L
L
S
A
L
S
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
L
R
L
P
L
V
S
L
E
D
T
D
T
K
V
L
R
E
T
Y
D
T
F
K
A
----
23
PsiBlast_CBE
97.43
98%
-108
- C3 -
3DAQ
4
DAPA_STAAR
D:
[1-292]
-
T
H
L
F
E
G
V
G
V
A
L
T
T
P
-
F
-
T
-
N
N
-
K
V
N
L
E
A
L
K
A
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
L
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
-
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
-
V
-
E
I
L
S
-
Q
H
P
Y
I
V
A
L
K
D
A
T
N
--
D
F
E
Y
L
E
E
V
K
K
--
R
I
D
T
--
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
-----
A
L
Y
D
A
-----
Q
-----
Q
S
G
-----
L
-----
D
I
Q
D
Q
F
-------
K
P
I
G
T
L
L
S
A
L
S
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
L
R
L
P
L
V
S
L
E
D
T
D
T
K
V
L
R
E
A
Y
D
T
F
K
A
G
E
--
2
PsiBlast_PDB
96.91
97%
-111
- C3 -
3DI1
1
DAPA_STAAC
A:
[2-291]
-
T
H
L
F
E
G
V
G
V
A
L
T
T
P
-
F
-
T
-
N
N
-
K
V
N
I
E
A
L
K
T
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
R
I
L
K
T
V
I
D
L
V
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
M
L
-
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
-
V
-
E
I
L
S
-
Q
H
P
Y
I
V
A
L
K
D
A
T
N
--
D
F
E
Y
L
E
E
V
K
K
--
R
I
D
T
--
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
-----
A
L
Y
D
A
-----
Q
-----
Q
S
G
-----
L
-----
D
I
Q
D
Q
F
-------
K
P
I
G
T
L
L
S
A
L
S
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
L
R
L
P
L
V
S
L
E
D
T
D
T
K
V
L
R
E
T
Y
D
T
F
K
A
----
102
Fugue
72.83
34%
-95
- C3 -
1DHP
1
DAPA_ECOLI
A:
[1-292]
---
M
F
T
G
S
I
V
A
I
V
T
P
-
M
-
D
-
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
-
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
-
V
-
G
R
L
A
-
K
V
K
N
I
I
G
I
K
E
A
T
G
--
N
L
T
R
V
N
Q
I
K
E
--
L
V
S
D
--
D
-
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
-----
Q
M
C
K
L
-----
A
-----
A
E
G
H
F
---
A
-----
E
A
R
V
I
N
-------
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
---
37
PsiBlast_CBE
71.87
36%
-99
- C3 -
2EHH
1
DAPA_AQUAE
C:
[2-288]
----
F
Q
G
S
I
V
A
L
I
T
P
-
F
-
K
-
E
G
-
E
V
D
Y
E
A
L
G
N
L
I
E
F
H
V
D
N
G
T
D
A
I
L
V
C
G
T
T
G
E
S
P
T
L
T
F
E
E
H
E
K
V
I
E
F
A
V
K
R
A
A
G
R
I
K
V
I
A
G
T
G
G
N
A
T
H
E
A
V
H
L
T
A
H
A
K
E
V
G
A
D
G
A
L
V
-
V
V
P
Y
Y
N
K
P
T
Q
R
G
L
Y
E
H
F
K
T
V
A
Q
E
V
D
I
P
I
I
I
Y
N
I
P
S
R
T
C
V
E
I
S
V
D
T
-
M
F
K
L
A
S
-
E
C
E
N
I
V
A
S
K
E
S
T
P
--
N
M
D
R
I
S
E
I
V
K
--
R
L
G
---
E
S
F
S
V
L
S
G
D
D
S
L
T
L
P
M
M
A
L
G
A
K
G
V
I
S
V
A
N
N
V
M
P
R
E
V
K
-----
E
L
I
R
A
-----
A
-----
L
E
G
DF---
R
-----
R
A
R
E
I
H
-------
Y
Y
L
H
D
L
F
K
V
L
F
I
E
T
N
P
I
P
V
K
T
A
C
W
M
L
G
M
-
C
E
K
E
F
R
L
P
L
T
E
M
S
P
E
N
E
N
K
L
R
E
V
L
K
K
Y
------
35
PsiBlast_CBE
71.55
36%
-98
- C3 -
2EHH
1
DAPA_AQUAE
E:
[1-288]
---
M
F
Q
G
S
I
V
A
L
I
T
P
-
F
-
K
-
E
G
-
E
V
D
Y
E
A
L
G
N
L
I
E
F
H
V
D
N
G
T
D
A
I
L
V
C
G
T
T
G
E
S
P
T
L
T
F
E
E
H
E
K
V
I
E
F
A
V
K
R
A
A
G
R
I
K
V
I
A
G
T
G
G
N
A
T
H
E
A
V
H
L
T
A
H
A
K
E
V
G
A
D
G
A
L
V
-
V
V
P
Y
Y
N
K
P
T
Q
R
G
L
Y
E
H
F
K
T
V
A
Q
E
V
D
I
P
I
I
I
Y
N
I
P
S
R
T
C
V
E
I
S
V
D
T
-
M
F
K
L
A
S
-
E
C
E
N
I
V
A
S
K
E
S
T
P
--
N
M
D
R
I
S
E
I
V
K
--
R
L
G
---
E
S
F
S
V
L
S
G
D
D
S
L
T
L
P
M
M
A
L
G
A
K
G
V
I
S
V
A
N
N
V
M
P
R
E
V
K
-----
E
L
I
R
A
-----
A
-----
L
E
G
DF---
R
-----
R
A
R
E
I
H
-------
Y
Y
L
H
D
L
F
K
V
L
F
I
E
T
N
P
I
P
V
K
T
A
C
W
M
L
G
M
-
C
E
K
E
F
R
L
P
L
T
E
M
S
P
E
N
E
N
K
L
R
E
V
L
K
K
Y
------
41
PsiBlast_CBE
71.21
37%
-91
- C3 -
1XKY
2
?
D:
[13-299]
----
F
G
T
I
A
T
A
M
V
T
P
-
F
D
I
-
N
G
-
N
I
D
F
A
K
T
T
K
L
V
N
Y
L
I
D
N
G
T
T
A
I
V
V
G
G
T
T
G
E
S
P
T
L
T
S
E
E
K
V
A
L
Y
R
H
V
V
S
V
V
D
K
R
V
P
V
I
A
G
T
G
S
N
N
T
H
A
S
I
D
L
T
K
K
A
T
E
V
G
V
D
A
V
M
L
-
V
A
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
E
S
T
P
L
P
V
M
L
Y
N
V
P
G
R
S
I
V
Q
I
S
V
D
T
-
V
-
V
R
L
S
-
E
I
E
N
I
V
A
I
K
D
A
G
G
--
D
V
L
T
M
T
E
I
I
E
--
K
-
T
A
--
D
D
F
A
V
Y
S
G
D
D
G
L
T
L
P
A
M
A
V
G
A
K
G
I
V
S
V
A
S
H
V
I
G
N
E
M
Q
-----
E
M
I
A
A
-----
F
-----
Q
A
G
EF---
K
-----
K
A
Q
K
L
H
-------
Q
L
L
V
R
V
T
D
S
L
F
M
A
P
S
P
T
P
V
K
T
A
L
Q
M
V
G
L
-
D
V
G
S
V
R
L
P
L
L
P
L
T
E
E
E
R
V
T
L
Q
S
V
M
Q
S
I
------
9
PsiBlast_PDB
71.21
36%
-97
- C3 -
2EHH
1
DAPA_AQUAE
A:
[1-288]
---
M
F
Q
G
S
I
V
A
L
I
T
P
-
F
-
K
-
E
G
-
E
V
D
Y
E
A
L
G
N
L
I
E
F
H
V
D
N
G
T
D
A
I
L
V
C
G
T
T
G
E
S
P
T
L
T
F
E
E
H
E
K
V
I
E
F
A
V
K
R
A
A
G
R
I
K
V
I
A
G
T
G
G
N
A
T
H
E
A
V
H
L
T
A
H
A
K
E
V
G
A
D
G
A
L
V
-
V
V
P
Y
Y
N
K
P
T
Q
R
G
L
Y
E
H
F
K
T
V
A
Q
E
V
D
I
P
I
I
I
Y
N
I
P
S
R
T
C
V
E
I
S
V
D
T
-
M
F
K
L
A
S
-
E
C
E
N
I
V
A
S
K
E
S
T
P
--
N
M
D
R
I
S
E
I
V
K
--
R
L
G
---
E
S
F
S
V
L
S
G
D
D
S
L
T
L
P
M
M
A
L
G
A
K
G
V
I
S
V
A
N
N
V
M
P
R
E
V
K
-----
E
L
I
R
A
-----
A
-----
L
E
G
D
F
---
R
-----
R
A
R
E
I
H
-------
Y
Y
L
H
D
L
F
K
V
L
F
I
E
T
N
P
I
P
V
K
T
A
C
W
M
L
G
M
-
C
E
K
E
F
R
L
P
L
T
E
M
S
P
E
N
E
N
K
L
R
E
V
L
K
K
Y
------
131
HHSearch
71.15
40%
-98
- C3 -
2YXG
-
DAPA_METJA
A:
[1-288]
---
M
F
K
G
V
Y
P
A
I
I
T
P
-
F
-
K
-
N
K
-
E
V
D
F
D
G
L
E
E
N
I
N
F
L
I
E
N
G
V
S
G
I
V
A
V
G
T
T
G
E
S
P
T
L
S
H
E
E
H
K
K
V
I
E
K
V
V
D
V
V
N
G
R
V
Q
V
I
A
G
A
G
S
N
C
T
E
E
A
I
E
L
S
V
F
A
E
D
V
G
A
D
A
V
L
S
-
I
T
P
Y
Y
N
K
P
T
Q
E
G
L
R
K
H
F
G
K
V
A
E
S
I
N
L
P
I
V
L
Y
N
V
P
S
R
T
A
V
N
L
E
P
K
T
-
V
-
K
L
L
A
E
E
Y
S
N
I
S
A
V
K
E
A
N
P
--
N
L
S
Q
V
S
E
L
I
H
-----
D
--
A
K
I
T
V
L
S
G
N
D
E
L
T
L
P
I
I
A
L
G
G
K
G
V
I
S
V
V
A
N
I
V
P
K
E
F
V
-----
E
M
V
N
Y
-----
A
-----
L
E
G
-----
D
F
E
K
A
R
E
I
H
Y
K
L
-------
F
P
L
M
K
A
M
---
F
I
E
T
N
P
I
P
V
K
T
A
L
N
M
M
G
R
-
P
A
G
E
L
R
L
P
L
C
E
M
S
E
E
H
K
K
I
L
E
N
V
L
K
D
L
G
L
----
36
PsiBlast_CBE
71.13
36%
-97
- C3 -
2EHH
1
DAPA_AQUAE
D:
[2-288]
----
F
Q
G
S
I
V
A
L
I
T
P
-
F
-
K
-
E
G
-
E
V
D
Y
E
A
L
G
N
L
I
E
F
H
V
D
N
G
T
D
A
I
L
V
C
G
T
T
G
E
S
P
T
L
T
F
E
E
H
E
K
V
I
E
F
A
V
K
R
A
A
G
R
I
K
V
I
A
G
T
G
G
N
A
T
H
E
A
V
H
L
T
A
H
A
K
E
V
G
A
D
G
A
L
V
-
V
V
P
Y
Y
N
K
P
T
Q
R
G
L
Y
E
H
F
K
T
V
A
Q
E
V
D
I
P
I
I
I
Y
N
I
P
S
R
T
C
V
E
I
S
V
D
T
-
M
F
K
L
A
S
-
E
C
E
N
I
V
A
S
K
E
S
T
P
--
N
M
D
R
I
S
E
I
V
K
--
R
L
G
---
E
S
F
S
V
L
S
G
D
D
S
L
T
L
P
M
M
A
L
G
A
K
G
V
I
S
V
A
N
N
V
M
P
R
E
V
K
-----
E
L
I
R
A
-----
A
-----
L
E
G
DF---
R
-----
R
A
R
E
I
H
-------
Y
Y
L
H
D
L
F
K
V
L
F
I
E
T
N
P
I
P
V
K
T
A
C
W
M
L
G
M
-
C
E
K
E
F
R
L
P
L
T
E
M
S
P
E
N
E
N
K
L
R
E
V
L
K
K
Y
------
113
HHSearch
70.85
40%
-93
* C3 *
3QZE
2
DAPA_PSEAE
A:
[23-312]
---
M
I
A
G
S
M
V
A
L
V
T
P
-
F
-
D
-
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
E
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
I
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
L
L
-
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
-
V
-
E
R
L
S
-
K
V
P
N
I
I
G
I
K
E
A
T
G
--
D
L
Q
R
A
K
E
V
I
E
--
R
V
-
G
--
K
D
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
-----
D
L
C
A
A
-----
A
-----
M
R
G
-----
D
A
A
A
A
R
A
I
N
D
R
L
-------
M
P
L
H
K
A
L
---
F
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
-
I
P
E
G
I
R
L
P
L
T
W
L
S
P
R
C
H
E
P
L
R
Q
A
M
R
Q
T
G
V
----
27
PsiBlast_CBE
70.69
39%
-96
- C3 -
3PB2
1
DAPA_THEMA
D:
[7-291]
---
M
F
R
G
V
G
T
A
I
V
T
P
-
F
-
K
-
N
G
-
E
L
D
L
E
S
Y
E
R
L
V
R
Y
Q
L
E
N
G
V
N
A
L
I
V
L
G
T
T
G
E
S
P
T
V
N
E
D
E
R
E
K
L
V
S
R
T
L
E
I
V
D
G
K
I
P
V
I
V
G
A
G
T
N
S
T
E
K
T
L
K
L
V
K
Q
A
E
K
L
G
A
N
G
V
L
V
-
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
Y
I
S
E
R
T
D
L
G
I
V
V
Y
N
V
P
G
R
T
G
V
N
V
L
P
E
T
A
A
-
R
I
A
A
-
D
L
K
N
V
V
G
I
K
E
A
N
P
--
D
I
D
Q
I
D
R
T
V
S
LT
K
Q
A
R
--
S
D
F
M
V
W
S
G
N
D
D
R
T
F
Y
L
L
C
A
G
G
D
G
V
I
S
V
V
S
N
V
A
P
K
Q
M
V
-----
E
L
C
A
E
-----
Y
-----
F
S
G
NLEKS
A
-----
E
V
H
A
K
L
-------
R
P
---
L
M
K
A
L
F
V
E
T
N
P
I
P
V
K
A
A
L
N
L
M
G
F
-
I
E
N
E
L
R
L
P
L
V
P
A
S
E
K
T
V
E
L
L
R
------------
31
PsiBlast_CBE
70.39
38%
-98
- C3 -
3PB0
2
DAPA_THEMA
C:
[7-291]
---
M
F
R
G
V
G
T
A
I
V
T
P
-
F
-
K
-
N
G
-
E
L
D
L
E
S
Y
E
R
L
V
R
Y
Q
L
E
N
G
V
N
A
L
I
V
L
G
T
T
G
E
S
P
T
V
N
E
D
E
R
E
K
L
V
S
R
T
L
E
I
V
D
G
K
I
P
V
I
V
G
A
G
T
N
S
T
E
K
T
L
K
L
V
K
Q
A
E
K
L
G
A
N
G
V
L
V
-
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
Y
I
S
E
R
T
D
L
G
I
V
V
Y
N
V
P
G
R
T
G
V
N
V
L
P
E
T
A
A
-
R
I
A
A
-
D
L
K
N
V
V
G
I
K
E
A
N
P
--
A
A
A
Q
I
D
R
T
V
S
LT
K
Q
A
R
--
S
D
F
M
V
W
S
G
N
D
D
R
T
F
Y
L
L
C
A
G
G
D
G
V
I
S
V
V
S
N
V
A
P
K
Q
M
V
-----
E
L
C
A
E
-----
Y
-----
F
S
G
NLEKS
R
-----
E
V
H
R
K
L
-------
R
P
---
L
M
K
A
L
F
V
E
T
N
P
I
P
V
K
A
A
L
N
L
M
G
F
-
I
E
N
E
L
R
L
P
L
V
P
A
S
E
K
T
V
E
L
L
R
------------
7
PsiBlast_PDB
70.24
38%
-98
- C3 -
3PB0
1
DAPA_THEMA
A:
[7-291]
---
M
F
R
G
V
G
T
A
I
V
T
P
-
F
-
K
-
N
G
-
E
L
D
L
E
S
Y
E
R
L
V
R
Y
Q
L
E
N
G
V
N
A
L
I
V
L
G
T
T
G
E
S
P
T
V
N
E
D
E
R
E
K
L
V
S
R
T
L
E
I
V
D
G
K
I
P
V
I
V
G
A
G
T
N
S
T
E
K
T
L
K
L
V
K
Q
A
E
K
L
G
A
N
G
V
L
V
-
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
Y
I
S
E
R
T
D
L
G
I
V
V
Y
N
V
P
G
R
T
G
V
N
V
L
P
E
T
A
A
-
R
I
A
A
-
D
L
K
N
V
V
G
I
K
E
A
N
P
--
A
A
A
Q
I
D
R
T
V
S
L
T
K
Q
A
R
--
S
D
F
M
V
W
S
G
N
D
D
R
T
F
Y
L
L
C
A
G
G
D
G
V
I
S
V
V
S
N
V
A
P
K
Q
M
V
-----
E
L
C
A
E
-----
Y
-----
F
S
G
N
L
E
K
S
R
-----
E
V
H
R
K
L
-------
R
P
---
L
M
K
A
L
F
V
E
T
N
P
I
P
V
K
A
A
L
N
L
M
G
F
-
I
E
N
E
L
R
L
P
L
V
P
A
S
E
K
T
V
E
L
L
R
------------
123
HHSearch
69.67
34%
-90
- C3 -
3SI9
3
DAPA_BARHE
A:
[21-314]
--
S
M
L
K
G
A
V
T
A
L
I
T
P
-
F
-
D
-
D
N
G
A
I
D
E
K
A
F
C
N
F
V
E
W
Q
I
T
Q
G
I
N
G
V
S
P
V
G
T
T
G
E
S
P
T
L
T
H
E
E
H
K
R
I
I
E
L
C
V
E
Q
V
A
K
R
V
P
V
V
A
G
A
G
S
N
S
T
S
E
A
V
E
L
A
K
H
A
E
K
A
G
A
D
A
V
L
V
-
V
T
P
Y
Y
N
R
P
N
Q
R
G
L
Y
T
H
F
S
S
I
A
K
A
I
S
I
P
I
I
I
Y
N
I
P
S
R
S
V
I
D
M
A
V
E
T
-
M
-
R
D
L
C
R
D
F
K
N
I
I
G
V
K
D
A
T
G
--
K
I
E
R
A
S
E
Q
R
E
--
K
C
-
G
--
K
D
F
V
Q
L
S
G
D
D
C
T
A
L
G
F
N
A
H
G
G
V
G
C
I
S
V
S
S
N
V
A
P
K
L
C
A
-----
Q
L
H
A
A
-----
C
-----
L
C
S
-----
D
Y
K
T
A
L
K
L
N
D
L
L
-------
M
P
L
N
R
A
V
---
F
I
E
P
S
P
A
G
I
K
Y
A
A
A
K
L
G
L
-
C
G
T
I
V
R
S
P
I
V
P
L
S
D
T
T
K
K
I
I
D
E
A
L
Y
H
A
G
L
L
K
--
68
PsiBlast_CBE
69.23
35%
-94
- C3 -
3G0S
4
DAPA_SALTY
A:
[25-309]
---
M
F
T
G
S
I
V
A
L
V
T
P
-
M
D
E
-
K
G
-
N
V
S
R
S
C
L
K
K
L
I
D
Y
H
V
A
N
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
S
H
D
E
H
G
D
V
V
M
M
T
L
E
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
-
V
T
P
Y
Y
N
R
P
T
Q
E
G
L
F
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
M
L
P
E
T
-
V
-
G
R
L
A
-
E
I
K
N
I
I
A
I
K
E
A
T
G
--
N
L
T
R
V
H
Q
I
K
E
--
L
V
-
S
--
D
D
F
I
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
E
M
A
-----
D
M
C
K
L
-----
A
-----
A
E
G
Q
F
A
E
A
R
-----
A
I
N
Q
R
L
-------
M
P
---
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
A
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
H
G
R
D
I
V
K
A
A
----------
67
PsiBlast_CBE
69.10
35%
-94
- C3 -
3G0S
4
DAPA_SALTY
B:
[25-309]
---
M
F
T
G
S
I
V
A
L
V
T
P
-
M
D
E
-
K
G
-
N
V
S
R
S
C
L
K
K
L
I
D
Y
H
V
A
N
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
S
H
D
E
H
G
D
V
V
M
M
T
L
E
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
-
V
T
P
Y
Y
N
R
P
T
Q
E
G
L
F
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
M
L
P
E
T
-
V
-
G
R
L
A
-
E
I
K
N
I
I
A
I
K
E
A
T
G
--
N
L
T
R
V
H
Q
I
K
E
--
L
V
-
S
--
D
D
F
I
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
E
M
A
-----
D
M
C
K
L
-----
A
-----
A
E
G
Q
F
A
E
A
R
-----
A
I
N
Q
R
L
-------
M
P
---
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
A
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
H
G
R
D
I
V
K
A
A
----------
114
HHSearch
67.82
34%
-86
- C3 -
3FLU
13
DAPA_NEIMB
A:
[4-296]
P
F
T
M
L
Q
G
S
L
V
A
L
I
T
P
-
M
-
N
-
Q
D
G
S
I
H
Y
E
Q
L
R
D
L
I
D
W
H
I
E
N
G
T
D
G
I
V
A
V
G
T
T
G
E
S
A
T
L
S
V
E
E
H
T
A
V
I
E
A
V
V
K
H
V
A
K
R
V
P
V
I
A
G
T
G
A
N
N
T
V
E
A
I
A
L
S
Q
A
A
E
K
A
G
A
D
Y
T
L
S
-
V
V
P
Y
Y
N
K
P
S
Q
E
G
I
Y
Q
H
F
K
T
I
A
E
A
T
S
I
P
M
I
I
Y
N
V
P
G
R
T
V
V
S
M
T
N
D
T
-
I
-
L
R
L
A
-
E
I
P
N
I
V
G
V
K
E
A
S
G
--
N
I
G
S
N
I
E
L
I
N
--
R
A
-
P
--
E
G
F
V
V
L
S
G
D
D
H
T
A
L
P
F
M
L
C
G
G
H
G
V
I
T
V
A
A
N
A
A
P
K
L
F
A
-----
D
M
C
R
A
-----
A
-----
L
Q
G
-----
D
I
A
L
A
R
E
L
N
D
R
L
-------
I
P
I
Y
D
T
M
---
F
C
E
P
S
P
A
A
P
K
W
A
V
S
A
L
G
R
-
C
E
P
H
V
R
L
P
L
V
P
L
T
E
N
G
Q
A
K
V
R
A
A
L
K
A
S
G
Q
----
119
HHSearch
67.26
35%
-94
- C3 -
3TAK
3
?
A:
[1-290]
---
T
I
Q
G
S
I
V
A
I
V
T
P
-
M
-
L
-
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
-
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
-
A
-
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
--
D
V
P
R
G
K
A
L
I
D
--
A
L
-
N
--
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
-----
E
V
C
A
V
-----
A
-----
I
A
K
-----
D
E
Q
Q
A
K
T
L
N
N
K
I
-------
A
N
L
H
N
I
L
---
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
-
I
D
T
G
I
R
L
P
L
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
----
72
PsiBlast_CBE
66.79
35%
-89
- C3 -
1YXD
3
DAPA_ECOLI
A:
[1-285]
---
M
F
T
G
S
I
V
A
I
V
T
P
-
M
D
E
-
K
G
-
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
-
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
-
V
-
G
R
L
A
-
K
V
K
N
I
I
G
I
K
E
A
T
G
--
N
L
T
R
V
N
Q
I
K
E
--
L
V
-
S
--
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
----------
A
-----
Q
-----
M
C
K
-----
L
-----
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
----------
69
PsiBlast_CBE
66.75
35%
-89
- C3 -
2ATS
3
DAPA_ECOLI
B:
[1-285]
---
M
F
T
G
S
I
V
A
I
V
T
P
-
M
D
E
-
K
G
-
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
-
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
-
V
-
G
R
L
A
-
K
V
K
N
I
I
G
I
K
E
A
T
G
--
N
L
T
R
V
N
Q
I
K
E
--
L
V
-
S
--
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
----------
A
-----
Q
-----
M
C
K
-----
L
-----
A
A
E
G
H
F
AEARVIN
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
----------
71
PsiBlast_CBE
66.65
35%
-89
- C3 -
1YXD
4
DAPA_ECOLI
B:
[1-285]
---
M
F
T
G
S
I
V
A
I
V
T
P
-
M
D
E
-
K
G
-
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
-
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
-
V
-
G
R
L
A
-
K
V
K
N
I
I
G
I
K
E
A
T
G
--
N
L
T
R
V
N
Q
I
K
E
--
L
V
-
S
--
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
----------
A
-----
Q
-----
M
C
K
-----
L
-----
A
A
E
G
H
F
AEARVIN
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
----------
79
PsiBlast_CBE
66.56
35%
-90
- C3 -
3I7R
8
DAPA_ECOLI
B:
[1-285]
---
M
F
T
G
S
I
V
A
I
V
T
P
-
M
D
E
-
K
G
-
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
-
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
-
V
-
G
R
L
A
-
K
V
K
N
I
I
G
I
R
E
A
T
G
--
N
L
T
R
V
N
Q
I
K
E
--
L
V
-
S
--
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
----------
A
-----
Q
-----
M
C
K
-----
L
-----
A
A
E
G
H
F
AEARVIN
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
----------
70
PsiBlast_CBE
65.84
35%
-88
- C3 -
2ATS
3
DAPA_ECOLI
A:
[1-285]
---
M
F
T
G
S
I
V
A
I
V
T
P
-
M
D
E
-
K
G
-
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
-
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
-
V
-
G
R
L
A
-
K
V
K
N
I
I
G
I
K
E
A
T
G
--
N
L
T
R
V
N
Q
I
K
E
--
L
V
-
S
--
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
----------
A
-----
Q
-----
M
C
K
-----
L
-----
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
----------
78
PsiBlast_CBE
65.82
35%
-88
- C3 -
3I7S
10
DAPA_ECOLI
A:
[1-285]
---
M
F
T
G
S
I
V
A
I
V
T
P
-
M
D
E
-
K
G
-
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
-
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
-
V
-
G
R
L
A
-
K
V
K
N
I
I
G
I
R
E
A
T
G
--
N
L
T
R
V
N
Q
I
K
E
--
L
V
-
S
--
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
----------
A
-----
Q
-----
M
C
K
-----
L
-----
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
----------
80
PsiBlast_CBE
65.79
35%
-88
- C3 -
3I7R
10
DAPA_ECOLI
A:
[1-285]
---
M
F
T
G
S
I
V
A
I
V
T
P
-
M
D
E
-
K
G
-
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
-
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
-
V
-
G
R
L
A
-
K
V
K
N
I
I
G
I
R
E
A
T
G
--
N
L
T
R
V
N
Q
I
K
E
--
L
V
-
S
--
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
----------
A
-----
Q
-----
M
C
K
-----
L
-----
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
----------
81
PsiBlast_CBE
65.37
35%
-89
- C3 -
3I7Q
7
DAPA_ECOLI
B:
[1-285]
---
M
F
T
G
S
I
V
A
I
V
T
P
-
M
D
E
-
K
G
-
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
-
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
-
V
-
G
R
L
A
-
K
V
K
N
I
I
G
I
R
E
A
T
G
--
N
L
T
R
V
N
Q
I
K
E
--
L
V
-
S
--
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
----------
A
-----
Q
-----
M
C
K
-----
L
-----
A
A
E
G
H
F
AEARVIN
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
----------
82
PsiBlast_CBE
65.31
35%
-87
- C3 -
3I7Q
7
DAPA_ECOLI
A:
[1-285]
---
M
F
T
G
S
I
V
A
I
V
T
P
-
M
D
E
-
K
G
-
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
-
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
-
V
-
G
R
L
A
-
K
V
K
N
I
I
G
I
R
E
A
T
G
--
N
L
T
R
V
N
Q
I
K
E
--
L
V
-
S
--
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
----------
A
-----
Q
-----
M
C
K
-----
L
-----
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
----------
77
PsiBlast_CBE
64.81
35%
-86
- C3 -
3I7S
13
DAPA_ECOLI
B:
[1-285]
---
M
F
T
G
S
I
V
A
I
V
T
P
-
M
D
E
-
K
G
-
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
L
T
-
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
-
V
-
G
R
L
A
-
K
V
K
N
I
I
G
I
R
E
A
T
G
--
N
L
T
R
V
N
Q
I
K
E
--
L
V
-
S
--
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
----------
A
-----
Q
-----
M
C
K
-----
L
-----
A
A
E
G
H
F
AEARVIN
Q
R
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
----------
85
PsiBlast_CBE
64.58
35%
-93
- C3 -
4PFM
6
?
B:
[1-276]
--
H
M
I
N
G
S
I
V
A
L
I
T
P
-
L
N
S
-
D
G
-
T
V
D
Y
T
S
L
E
K
L
V
E
Y
H
I
T
E
G
T
D
A
I
V
A
V
G
T
T
G
E
S
A
T
L
P
I
S
E
H
I
A
V
V
G
Q
T
V
K
F
A
S
G
R
I
P
V
I
G
G
N
G
A
N
A
T
A
E
A
I
E
L
T
K
A
Q
N
K
L
G
V
A
A
M
L
G
-
V
T
P
Y
Y
N
K
P
S
P
K
G
L
I
A
H
Y
T
A
V
A
A
S
T
D
I
P
Q
I
L
Y
N
V
P
G
R
T
A
V
D
M
L
P
E
T
-
I
-
A
Q
L
V
-
E
V
P
N
I
I
G
V
-
D
A
T
G
--
D
V
A
R
V
K
Q
L
R
D
---
L
C
G
--
N
D
F
L
L
Y
S
G
D
D
A
T
A
R
E
F
L
T
L
G
G
D
G
V
I
S
V
A
N
N
I
V
P
K
L
F
K
-----
L
M
C
D
A
-----
A
LAGDT
Q
A
A
-----
M
-----
A
A
E
D
Q
I
-------
K
---
G
L
F
S
A
L
F
C
E
A
N
P
I
P
V
K
W
A
A
H
K
M
G
L
I
S
Q
G
D
I
R
L
P
L
T
E
L
S
--------------------
86
PsiBlast_CBE
64.03
35%
-94
- C3 -
4PFM
5
?
A:
[1-276]
--
H
M
I
N
G
S
I
V
A
L
I
T
P
-
L
N
S
-
D
G
-
T
V
D
Y
T
S
L
E
K
L
V
E
Y
H
I
T
E
G
T
D
A
I
V
A
V
G
T
T
G
E
S
A
T
L
P
I
S
E
H
I
A
V
V
G
Q
T
V
K
F
A
S
G
R
I
P
V
I
G
G
N
G
A
N
A
T
A
E
A
I
E
L
T
K
A
Q
N
K
L
G
V
A
A
M
L
G
-
V
T
P
Y
Y
N
K
P
S
P
K
G
L
I
A
H
Y
T
A
V
A
A
S
T
D
I
P
Q
I
L
Y
N
V
P
G
R
T
A
V
D
M
L
P
E
T
-
I
-
A
Q
L
V
-
E
V
P
N
I
I
G
V
-
D
A
T
G
--
D
V
A
R
V
K
Q
L
R
D
---
L
C
G
--
N
D
F
L
L
Y
S
G
D
D
A
T
A
R
E
F
L
T
L
G
G
D
G
V
I
S
V
A
N
N
I
V
P
K
L
F
K
-----
L
M
C
D
A
-----
A
L
A
GD
T
Q
A
A
-----
M
-----
A
A
E
D
Q
I
-------
K
---
G
L
F
S
A
L
F
C
E
A
N
P
I
P
V
K
W
A
A
H
K
M
G
L
I
S
Q
G
D
I
R
L
P
L
T
E
L
S
--------------------
94
PsiBlast_CBE
63.95
34%
-83
- C3 -
3FLU
13
DAPA_NEIMB
A:
[7-290]
---
M
L
Q
G
S
L
V
A
L
I
T
P
-
M
-
N
Q
D
G
-
S
I
H
Y
E
Q
L
R
D
L
I
D
W
H
I
E
N
G
T
D
G
I
V
A
V
G
T
T
G
E
S
A
T
L
S
V
E
E
H
T
A
V
I
E
A
V
V
K
H
V
A
K
R
V
P
V
I
A
G
T
G
A
N
N
T
V
E
A
I
A
L
S
Q
A
A
E
K
A
G
A
D
Y
T
L
S
-
V
V
P
Y
Y
N
K
P
S
Q
E
G
I
Y
Q
H
F
K
T
I
A
E
A
T
S
I
P
M
I
I
Y
N
V
P
G
R
T
V
V
S
M
T
N
D
T
-
I
-
L
R
L
A
-
E
I
P
N
I
V
G
V
K
E
A
S
G
--
N
I
G
S
N
I
E
L
I
N
--
R
-
A
P
--
E
G
F
V
V
L
S
G
D
D
H
T
A
L
P
F
M
L
C
G
G
H
G
V
I
T
V
A
A
N
A
A
P
K
L
F
A
-----
D
M
C
R
A
-----
A
-----
L
Q
G
D
I
A
L
A
R
-----
E
L
N
D
R
L
-------
I
P
I
---
Y
D
T
M
F
C
E
P
S
P
A
A
P
K
W
A
V
S
A
L
G
R
-
C
E
P
H
V
R
L
P
L
V
P
L
T
E
N
G
Q
A
K
V
R
A
A
----------
93
PsiBlast_CBE
63.83
34%
-84
- C3 -
3FLU
12
DAPA_NEIMB
B:
[7-290]
---
M
L
Q
G
S
L
V
A
L
I
T
P
-
M
-
N
Q
D
G
-
S
I
H
Y
E
Q
L
R
D
L
I
D
W
H
I
E
N
G
T
D
G
I
V
A
V
G
T
T
G
E
S
A
T
L
S
V
E
E
H
T
A
V
I
E
A
V
V
K
H
V
A
K
R
V
P
V
I
A
G
T
G
A
N
N
T
V
E
A
I
A
L
S
Q
A
A
E
K
A
G
A
D
Y
T
L
S
-
V
V
P
Y
Y
N
K
P
S
Q
E
G
I
Y
Q
H
F
K
T
I
A
E
A
T
S
I
P
M
I
I
Y
N
V
P
G
R
T
V
V
S
M
T
N
D
T
-
I
-
L
R
L
A
-
E
I
P
N
I
V
G
V
K
E
A
S
G
--
N
I
G
S
N
I
E
L
I
N
--
R
-
A
P
--
E
G
F
V
V
L
S
G
D
D
H
T
A
L
P
F
M
L
C
G
G
H
G
V
I
T
V
A
A
N
A
A
P
K
L
F
A
-----
D
M
C
R
A
-----
A
-----
L
Q
G
D
I
A
L
A
R
-----
E
L
N
D
R
L
-------
I
P
I
---
Y
D
T
M
F
C
E
P
S
P
A
A
P
K
W
A
V
S
A
L
G
R
-
C
E
P
H
V
R
L
P
L
V
P
L
T
E
N
G
Q
A
K
V
R
A
A
----------
19
PsiBlast_PDB
61.33
37%
-83
- C3 -
3PUE
4
?
A:
[2-284]
----
I
Q
G
S
I
V
A
I
V
T
P
M
L
-
K
-
D
G
-
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
-
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
-
A
-
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
--
D
---
V
P
R
G
K
A
--
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
-----
E
-----
Q
Q
A
-----
K
-----
T
L
N
N
K
----------
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
-
I
D
T
G
I
R
L
P
L
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
----------
20
PsiBlast_PDB
61.29
37%
-81
- C3 -
3PUL
6
?
A:
[2-284]
----
I
Q
G
S
I
V
A
I
V
T
P
M
L
-
K
-
D
G
-
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
L
L
-
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
-
A
-
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
--
D
---
V
P
R
G
K
A
--
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
-----
E
-----
Q
Q
A
-----
K
-----
T
L
N
N
K
----------
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
-
I
D
T
G
I
R
L
P
L
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
----------
84
PsiBlast_CBE
58.70
37%
-81
- C3 -
3VFL
7
?
A:
[14-287]
----------
A
F
I
T
P
-
F
H
E
-
D
G
-
S
I
N
F
D
A
I
P
A
L
I
E
H
L
L
A
H
H
T
D
G
I
L
L
A
G
T
T
A
E
S
P
T
L
T
H
D
E
E
L
E
L
F
A
A
V
Q
K
V
V
N
G
R
V
P
L
I
A
G
V
G
T
N
D
T
R
D
S
I
E
F
V
K
E
V
A
E
F
G
G
F
A
A
G
L
A
I
V
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
D
A
S
D
L
P
I
I
I
Y
N
I
P
G
R
V
V
V
E
L
T
P
E
T
-
M
-
L
R
L
A
-
D
H
P
N
I
I
G
V
K
E
C
T
S
L
A
N
M
A
Y
L
I
E
H
K
P
--
E
------
E
F
L
I
Y
T
G
E
D
G
D
A
F
H
A
M
N
L
G
A
D
G
V
I
S
V
A
S
H
T
N
G
D
E
M
H
-----
E
M
F
T
A
I
A
E
SD
M
-----
K
K
A
-----
A
-----
A
I
Q
R
K
F
-------
I
P
---
K
V
N
A
L
F
S
Y
P
S
P
A
P
V
K
A
I
L
N
Y
M
G
F
-
E
A
G
P
T
R
L
P
L
V
P
A
P
E
E
D
V
K
---------------
83
PsiBlast_CBE
58.29
37%
-84
- C3 -
3VFL
7
?
B:
[14-289]
----------
A
F
I
T
P
-
F
H
E
-
D
G
-
S
I
N
F
D
A
I
P
A
L
I
E
H
L
L
A
H
H
T
D
G
I
L
L
A
G
T
T
A
E
S
P
T
L
T
H
D
E
E
L
E
L
F
A
A
V
Q
K
V
V
N
G
R
V
P
L
I
A
G
V
G
T
N
D
T
R
D
S
I
E
F
V
K
E
V
A
E
F
G
G
F
A
A
G
L
A
I
V
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
D
A
S
D
L
P
I
I
I
Y
N
I
P
G
R
V
V
V
E
L
T
P
E
T
-
M
-
L
R
L
A
-
D
H
P
N
I
I
G
V
K
E
C
T
S
LA
N
M
A
Y
L
I
E
H
K
P
--
E
------
E
F
L
I
Y
T
G
E
D
G
D
A
F
H
A
M
N
L
G
A
D
G
V
I
S
V
A
S
H
T
N
G
D
E
M
H
-----
E
M
F
T
A
IAESD
M
-----
K
K
A
-----
A
-----
A
I
Q
R
K
F
-------
I
P
---
K
V
N
A
L
F
S
Y
P
S
P
A
P
V
K
A
I
L
N
Y
M
G
F
-
E
A
G
P
T
R
L
P
L
V
P
A
P
E
E
D
V
K
---------------