@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2200: (2016-04-02 )
MIQLNNIHKSFNDVEVIKGIDLSVEQGEVVTLIGRSGSGKTTLLRMINALEIPTEGTVYVNGKTYTSKDKKSQIEVRKQSGMVFQSYNLFPHKTALENVMEGLITVKKLKKDEARGKSLELLEKVGLTHVKDQRPHALSGGQQQRVAIARALAMNPKVMLFDEPTSALDPELVNDVLKVIKDLANEGMTMVIVTHEMRFAKEVSNNIVFIHEGMIGEQGAPEEMFNRPKTEELRRFLNVINEE
Atome Classification :
(41 SA)
.........10....----....20........30........40........50........60.....-...----------70.....---------...80.....--....90........--------100......--.110.......120......-.130........140.......150.......160.......170......-.180..-..-...190.......200.......210.......220.......230.......240.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIQ
L
N
N
I
HKSFN
D
V
E
----
V
IKGIDLSVEQG
E
V
V
T
L
I
GRSGS
G
K
T
T
L
L
R
M
I
N
A
LEIPTE
G
T
V
Y
VNGKTYT-SKD----------K
K
S
Q
I
E
V
---------
R
KQS-
G
M
V
F
Q
--SYNLFP
H
K
T
A
L
E
N
V
--------
M
E
G
L
I
T
V
K
K
--
L
K
K
D
EARG
K
S
L
E
L
L
E
K
VGLT-HVK-DQRPHALSGG
Q
Q
Q
R
V
A
I
A
R
A
LAMNP
K
V
M
L
FDEPTSAL
D
P
E
L
V
N
D
V
L
K
-
V
I
K
D
L
A
-NE-G
M
T
M
V
I
V
TH
E
M
R
F
A
K
E
VSN
N
I
V
F
I
HEGMIGEQGA
P
E
E
M
FNRP
K
T
E
E
L
R
R
F
L
N
V
INEE
21
PsiBlast_CBE
96.39
57%
-102
- C1 -
4YMV
1
?
A:
[1-239]
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-
V
K
I
-
N
N
G
----------
K
V
N
I
N
K
V
---------
R
Q
K
V
-
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
--------
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
-
D
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
---
2
PsiBlast_PDB
95.45
57%
-103
- C1 -
4YMT
-
?
J:
[1-239]
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-
V
K
I
-
N
N
G
----------
K
V
N
I
N
K
V
---------
R
Q
K
V
-
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
--------
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
-
D
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
---
22
PsiBlast_CBE
94.75
57%
-103
- C1 -
4YMU
2
?
A:
[1-239]
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-
V
K
I
-
N
N
G
----------
K
V
N
I
N
K
V
---------
R
Q
K
V
-
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
--------
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
-
D
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
---
3
PsiBlast_PDB
94.38
57%
-100
- C1 -
4YMU
2
?
J:
[1-239]
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-
V
K
I
-
N
N
G
----------
K
V
N
I
N
K
V
---------
R
Q
K
V
-
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
--------
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
-
D
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
---
5
PsiBlast_PDB
94.34
57%
-104
- C1 -
4YMW
-
?
J:
[1-239]
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-
V
K
I
-
N
N
G
----------
K
V
N
I
N
K
V
---------
R
Q
K
V
-
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
--------
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
-
D
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
---
4
PsiBlast_PDB
94.24
57%
-102
- C1 -
4YMV
1
?
J:
[1-239]
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-
V
K
I
-
N
N
G
----------
K
V
N
I
N
K
V
---------
R
Q
K
V
-
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
--------
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
-
D
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
---
1
PsiBlast_PDB
93.43
57%
-104
- C1 -
4YMS
-
?
J:
[1-239]
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-
V
K
I
-
N
N
G
----------
K
V
N
I
N
K
V
---------
R
Q
K
V
-
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
--------
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
-
D
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
---
34
PsiBlast_CBE
92.82
52%
-98
- C1 -
2OLK
2
?
B:
[24-260]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-
A
K
D
----------
T
N
L
N
-
K
V
---------
R
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
--------
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----
11
PsiBlast_PDB
92.51
52%
-104
- C1 -
2OUK
1
?
A:
[24-260]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-
A
K
D
----------
T
N
L
N
-
K
V
---------
R
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
--------
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----
32
PsiBlast_CBE
92.19
52%
-100
- C1 -
2OLK
1
?
D:
[24-260]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-
A
K
D
----------
T
N
L
N
-
K
V
---------
R
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
--------
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----
14
PsiBlast_PDB
91.91
50%
-100
- C1 -
1B0U
4
HISP_SALTY
A:
[11-253]
-----
D
L
H
K
R
Y
G
G
H
E
----
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
----------
K
D
G
Q
L
K
V
AD
K
N
Q
L
R
L
L
R
T
R
L
-
T
M
V
F
Q
--
H
F
N
L
W
S
H
M
T
V
L
E
N
V
--------
M
E
A
P
I
Q
V
L
G
--
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
-
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
-
I
M
Q
Q
L
A
-
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
------
114
HHSearch
91.69
50%
-101
- C1 -
1B0U
4
HISP_SALTY
A:
[7-256]
-
L
H
V
I
D
L
H
K
R
Y
G
G
H
E
----
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
-
L
V
R
D
KDGQLKVAD
K
N
Q
L
R
L
L
---------
R
T
R
L
-
T
M
V
F
Q
--
H
F
N
L
W
S
H
M
T
V
L
E
N
V
--------
M
E
A
P
I
Q
V
L
G
--
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
-
E
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
-
I
M
Q
Q
L
A
-
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
S
---
12
PsiBlast_PDB
91.47
52%
-99
- C1 -
2Q0H
4
?
A:
[24-260]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-
A
K
D
----------
T
N
L
N
-
K
V
---------
R
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
--------
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----
6
PsiBlast_PDB
91.29
55%
-99
- C1 -
4U00
3
?
A:
[4-239]
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
----
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
-
V
K
D
----------
D
R
A
L
R
E
I
---------
R
R
E
V
-
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
--------
T
L
A
P
M
R
V
R
R
--
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
-
D
Q
A
-
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
-
V
M
R
D
L
A
-
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
-----
27
PsiBlast_CBE
91.15
52%
-102
- C1 -
3C4J
4
?
B:
[24-260]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-
A
K
D
----------
T
N
L
N
-
K
V
---------
R
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
--------
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----
7
PsiBlast_PDB
90.89
55%
-95
- C1 -
4U02
1
?
A:
[4-239]
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
----
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
-
V
K
D
----------
D
R
A
L
R
E
I
---------
R
R
E
V
-
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
--------
T
L
A
P
M
R
V
R
R
--
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
-
D
Q
A
-
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
-
V
M
R
D
L
A
-
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
-----
28
PsiBlast_CBE
90.78
52%
-97
- C1 -
2Q0H
4
?
B:
[24-260]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-
A
K
D
----------
T
N
L
N
-
K
V
---------
R
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
--------
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----
10
PsiBlast_PDB
90.67
52%
-97
- C1 -
2OLK
1
?
A:
[24-260]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-
A
K
D
----------
T
N
L
N
-
K
V
---------
R
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
--------
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----
113
HHSearch
90.63
53%
-105
- C1 -
2OLJ
4
?
A:
[24-261]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-
A
K
-----------
D
T
N
L
N
K
V
---------
R
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
--------
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
----
13
PsiBlast_PDB
90.47
52%
-98
- C1 -
3C4J
3
?
A:
[24-260]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-
A
K
D
----------
T
N
L
N
-
K
V
---------
R
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
--------
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----
9
PsiBlast_PDB
90.46
52%
-103
- C1 -
2OLJ
4
?
A:
[24-260]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-
A
K
D
----------
T
N
L
N
-
K
V
---------
R
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
--------
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----
33
PsiBlast_CBE
90.28
52%
-97
- C1 -
2OLK
1
?
C:
[24-260]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-
A
K
D
----------
T
N
L
N
-
K
V
---------
R
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
--------
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----
8
PsiBlast_PDB
89.32
52%
-97
- C1 -
3C41
3
?
J:
[3-239]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-
A
K
D
----------
T
N
L
N
-
K
V
---------
R
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
--------
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----
26
PsiBlast_CBE
89.25
52%
-95
- C1 -
3C41
3
?
K:
[3-239]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-
A
K
D
----------
T
N
L
N
-
K
V
---------
R
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
--------
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----
35
PsiBlast_CBE
89.09
52%
-94
- C1 -
2OLJ
3
?
B:
[24-260]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-
A
K
D
----------
T
N
L
N
-
K
V
---------
R
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
--------
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----
73
PsiBlast_CBE
71.91
38%
-106
- C1 -
3TIF
7
Y796_METJA
A:
[1-223]
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
-
D
L
D
----------
D
D
E
L
T
K
I
---------
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
--------
E
L
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
-
L
L
K
K
L
N
-
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
V
----------------------------
45
PsiBlast_CBE
71.86
39%
-104
- C1 -
1L2T
4
Y796_METJA
B:
[1-221]
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
EIIY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
-
D
L
D
----------
D
D
E
L
T
K
I
---------
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
--------
E
L
P
L
I
F
K
Y
R
GA
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
-
L
L
K
K
L
N
-
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
------------------------------
72
PsiBlast_CBE
71.72
38%
-108
- C1 -
3TIF
7
Y796_METJA
B:
[1-223]
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
EIIY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
-
D
L
D
----------
D
D
E
L
T
K
I
---------
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
--------
E
L
P
L
I
F
K
Y
R
GA
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
-
L
L
K
K
L
N
-
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
V
----------------------------
46
PsiBlast_CBE
71.65
39%
-103
- C1 -
1L2T
4
Y796_METJA
A:
[1-221]
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
-
D
L
D
----------
D
D
E
L
T
K
I
---------
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
--------
E
L
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
-
L
L
K
K
L
N
-
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
------------------------------
90
PsiBlast_CBE
70.19
35%
-89
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[5-240]
-
L
H
I
G
H
L
S
K
S
F
Q
N
T
P
----
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
-
S
K
N
----------
T
N
L
P
V
R
E
---------
R
R
L
--
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
--------
A
Y
G
L
G
N
G
K
G
--
R
T
A
Q
E
-
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
-
E
L
A
-
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
-
A
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
-----
91
PsiBlast_CBE
68.19
35%
-87
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-245]
-
L
H
I
G
H
L
S
K
S
F
Q
N
T
P
----
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
-
S
K
N
----------
T
N
L
P
V
R
E
---------
R
R
L
--
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
--------
A
Y
G
L
G
N
G
K
G
--
R
T
A
Q
E
-
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
-
E
L
A
-
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
-
A
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
-----
109
HHSearch
66.57
34%
-88
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-244]
A
L
H
I
G
H
L
S
K
S
F
Q
N
T
P
----
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
-
S
K
N
-----------
T
N
L
P
V
R
---------
E
R
R
L
-
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
--------
A
Y
G
L
G
N
G
K
---
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
-
E
L
A
-
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
-
D
M
I
A
A
L
R
A
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
------
76
PsiBlast_CBE
65.83
35%
-91
- C1 -
1VCI
1
?
A:
[13-249]
-
V
K
L
E
N
L
T
K
R
F
G
N
F
T
----
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
T
-
Y
L
P
----------
P
K
D
--------------
R
N
I
-
S
M
V
F
Q
--------
H
M
T
V
Y
E
N
I
--------
A
F
P
L
---
K
K
--
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
-
E
L
L
-
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
-
E
I
K
K
L
Q
-
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
------
85
PsiBlast_CBE
58.98
37%
-92
- C1 -
4MKI
4
ECFA2_CALS4
B:
[27-236]
--------------------
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
-
D
K
-----------
K
V
S
L
K
D
I
---------
R
K
Q
V
-
G
L
V
F
Q
YP
E
Y
Q
L
F
-
E
E
T
V
F
K
D
I
--------
A
F
G
P
S
N
L
G
---
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
-
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
-
K
I
K
E
I
H
-
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
------------------
86
PsiBlast_CBE
57.65
37%
-93
- C1 -
4MKI
4
ECFA2_CALS4
A:
[27-236]
--------------------
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
-
D
K
-----------
K
V
S
L
K
D
I
---------
R
K
Q
V
-
G
L
V
F
Q
YP
E
Y
Q
L
F
-
E
E
T
V
F
K
D
I
--------
A
F
G
P
S
N
L
G
---
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
-
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
-
K
I
K
E
I
H
-
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
------------------
95
PsiBlast_CBE
57.01
34%
-76
- C1 -
2FGK
2
D:
[24-241]
-------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
----------
P
N
---
W
L
---------
R
R
Q
V
-
G
V
V
L
Q
--
D
-
N
V
L
L
N
R
S
I
I
D
N
I
SLANPGMS
V
E
K
V
I
Y
A
A
K
--
L
A
G
--
A
H
D
F
I
S
E
L
R
E
--
G
Y
N
-
T
I
V
-
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
-
N
M
H
K
I
C
--
K
-
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
------
97
PsiBlast_CBE
56.78
34%
-75
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[24-241]
-------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
----------
P
N
---
W
L
---------
R
R
Q
V
-
G
V
V
L
Q
--
D
-
N
V
L
L
N
R
S
I
I
D
N
I
SLANPGMS
V
E
K
V
I
Y
A
A
K
--
L
A
G
--
A
H
D
F
I
S
E
L
R
E
--
G
Y
N
-
T
I
V
-
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
-
N
M
H
K
I
C
--
K
-
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
------
98
PsiBlast_CBE
55.93
34%
-79
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[24-241]
-------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
----------
P
N
---
W
L
---------
R
R
Q
V
-
G
V
V
L
Q
--
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LANPGMS
V
E
K
V
I
Y
A
A
K
--
L
A
G
--
A
H
D
F
I
S
E
L
R
E
--
G
Y
N
-
T
I
V
-
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
-
N
M
H
K
I
C
--
K
-
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
------
96
PsiBlast_CBE
55.43
34%
-77
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[24-241]
-------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
----------
P
N
---
W
L
---------
R
R
Q
V
-
G
V
V
L
Q
--
D
-
N
V
L
L
N
R
S
I
I
D
N
I
SLANPGMS
V
E
K
V
I
Y
A
A
K
--
L
A
G
--
A
H
D
F
I
S
E
L
R
E
--
G
Y
N
-
T
I
V
-
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
-
N
M
H
K
I
C
--
K
-
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
------
101
PsiBlast_CBE
52.03
34%
-75
- C1 -
2FGJ
2
D:
[24-241]
-------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
----------
P
N
---
W
L
---------
R
R
Q
V
-
G
V
V
L
Q
--
D
-
N
V
L
L
N
R
S
I
I
D
N
I
SLANPGMS
V
E
K
V
I
Y
A
A
K
--
L
A
G
--
A
H
D
F
I
S
E
L
R
E
--
G
Y
N
-
T
I
V
-
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
-
N
M
H
K
I
C
--
K
-
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
------
102
PsiBlast_CBE
50.74
34%
-83
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[24-241]
-------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
----------
P
N
---
W
L
---------
R
R
Q
V
-
G
V
V
L
Q
--
D
-
N
V
L
L
N
R
S
I
I
D
N
I
SLANPGMS
V
E
K
V
I
Y
A
A
K
--
L
A
G
--
A
H
D
F
I
S
E
L
R
E
--
G
Y
N
-
T
I
V
-
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
-
N
M
H
K
I
C
--
K
-
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
------