@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2252: (2016-04-02 )
MTLLTVKHLTITDTWTDQPLVSDVNFTLTKGETLGVIGESGSGKSITCKSIIGLNPERLGVTGEIIFDGTSMLSLSESQRKKYRGKDIAMVMQQGSRAFDPSTTVGKQMFETMKVHTSMSTQEIEKTLIEYMDYLSLKDPKRILKSYPYMLSGGMLQRLMIALALALKPKLIIADEPTTALDTITQYDVLEAFIDIKKHFDCAMIFISHDLTVINKIADRVVVMKNGQLIEHGTRESVLHHPEHVYTKYLLSTKKKINDHFKHVMRGDVHD
Atome Classification :
(28 SA)
.........10....--.--...20........30........40....--....50...-.....60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.--......260-........270----------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
L
L
T
V
K
H
L
T
I
TDTW--T--DQPLVSDV
N
F
T
LTKG
E
T
L
G
V
IGESGSG
K
S
--
I
T
C
K
S
IIGL-
N
P
E
RLGV
T
G
E
I
I
FDGT
S
M
L
SL
S
E
S
Q
R
K
KYRG
K
D
I
A
M
V
M
Q
QGSRAFDPS
T
T
V
G
K
Q
M
F
E
T
M
K
V
HTSM
S
T
Q
E
I
E
K
T
L
I
E
Y
M
D
Y
LSLK
D
P
K
R
I
L
K
SY
P
Y
M
LS
G
G
M
L
Q
R
L
M
I
A
L
A
L
ALK
P
K
L
I
I
ADEP
T
T
A
L
D
T
I
T
Q
Y
D
V
L
E
A
F
I
D
I
K
K
HF
D
C
A
M
I
F
ISH
D
L
T
V
I
N
K
IA
D
R
V
V
V
M
KN
G
Q
L
IEHG
T
R
E
S
V
LHH
P
E
H
V
Y
T
K
Y
L
L
S
T
--
K
K
K
I
N
D
H
F
--
K
H
V
M
RGDVHD-----------------------------------------------------------------------------------------
49
Fugue
93.69
28%
-108
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
-
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
GT
R
--
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
--
T
L
I
R
C
V
N
L
L
-
E
R
P
T
---
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
--
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
-
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
---
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TL
H
L
D
I
P
E
D
Y
--
Q
E
R
L
Q
A
E
P
F
T
DCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV-------------
5
PsiBlast_PDB
88.76
31%
-93
- C1 -
4U00
3
?
A:
[19-239]
-----------------------
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
--
T
L
I
R
T
I
N
R
L
-
E
D
F
Q
---
E
G
E
V
V
V
D
G
---
L
S
V
K
D
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
-
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
-
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
---
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
----------------------------------------------------------------------------------------------------------------
52
Fugue
88.70
27%
-105
- C1 -
1OXS
23
?
C:
[1-352]
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
--
G
--
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
--
T
F
M
R
I
I
A
G
L
-
D
V
P
S
---
T
G
E
L
Y
F
D
D
R
L
V
A
S
N
G
K
L
I
V
P
P
E
D
-
R
K
I
G
M
V
F
Q
--
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
L
T
N
M
-
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
---
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
--
I
N
E
L
E
G
K
V
TN
E
G
V
V
I
G
S
L
R
F
PVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
9
PsiBlast_PDB
88.57
33%
-95
- C1 -
2OLK
1
?
A:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-
F
D
E
-----
G
E
I
I
I
D
G
I
N
-
L
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
88.45
31%
-90
- C1 -
4U02
1
?
D:
[19-239]
-----------------------
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
--
T
L
I
R
T
I
N
R
L
-
E
D
F
Q
---
E
G
E
V
V
V
D
G
---
L
S
V
K
D
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
-
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
-
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
---
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
----------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
88.40
31%
-90
- C1 -
4U02
1
?
B:
[19-239]
-----------------------
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
--
T
L
I
R
T
I
N
R
L
-
E
D
F
Q
---
E
G
E
V
V
V
D
G
---
L
S
V
K
D
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
-
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
-
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
---
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
----------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
88.17
33%
-87
- C1 -
2OUK
2
?
B:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-
F
D
E
-----
G
E
I
I
I
D
G
I
N
-
L
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
88.16
33%
-93
- C1 -
2OLK
1
?
C:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
TF
L
R
C
L
N
L
L
E
D
-
F
D
E
-----
G
E
I
I
I
D
G
I
N
-
L
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
87.90
31%
-91
- C1 -
4U02
1
?
A:
[19-239]
-----------------------
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
--
T
L
I
R
T
I
N
R
L
-
E
D
F
Q
---
E
G
E
V
V
V
D
G
---
L
S
V
K
D
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
-
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
-
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
---
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
----------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
87.84
31%
-95
- C1 -
4U02
1
?
C:
[19-239]
-----------------------
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
--
T
L
I
R
T
I
N
R
L
-
E
D
F
Q
---
E
G
E
V
V
V
D
G
---
L
S
V
K
D
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
-
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
-
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
---
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
----------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
87.26
26%
-120
- C1 -
2IT1
-
?
A:
[1-236]
--
M
V
E
I
K
L
E
N
I
V
K
K
F
--
G
--
N
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
--
T
L
L
Y
T
I
A
G
I
Y
K
P
----
T
S
G
K
I
Y
F
D
E
K
D
V
T
E
L
P
P
K
D
R
------
N
V
G
L
V
F
Q
--
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
L
E
L
R
K
A
-
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
---
K
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
N
---------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
87.24
33%
-96
- C1 -
3C4J
4
?
B:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
TF
L
R
C
L
N
L
L
E
D
-
F
D
E
-----
G
E
I
I
I
D
G
I
N
-
L
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
86.93
33%
-88
- C1 -
2Q0H
4
?
A:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-
F
D
E
-----
G
E
I
I
I
D
G
I
N
-
L
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------
61
HHSearch
86.66
31%
-111
- C1 -
3TUI
1
METN_ECOLI
C:
[23-259]
-
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
--
G
TR
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
--
T
L
I
R
C
V
N
L
L
-
E
R
P
T
---
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
-
R
R
Q
I
G
M
I
F
Q
H
F
N
--
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
---
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
----------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
86.14
33%
-92
- C1 -
2OLJ
4
?
A:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-
F
D
E
-----
G
E
I
I
I
D
G
I
N
-
L
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
86.00
33%
-92
- C1 -
2OUK
1
?
A:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-
F
D
E
-----
G
E
I
I
I
D
G
I
N
-
L
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------
62
HHSearch
85.96
28%
-117
- C1 -
1V43
-
?
A:
[11-246]
-
V
E
V
K
L
E
N
L
T
K
R
F
G
------
N
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
--
T
T
L
R
M
I
A
G
L
-
E
E
P
T
---
E
G
R
I
Y
F
G
D
R
D
V
T
Y
L
P
P
K
------
D
R
N
I
S
M
V
F
Q
--------
H
M
T
V
Y
E
N
I
A
F
P
L
--
K
K
-
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
---
E
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
--------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.84
33%
-90
- C1 -
3C41
3
?
J:
[22-239]
---------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
TF
L
R
C
L
N
L
L
E
D
-
F
D
E
-----
G
E
I
I
I
D
G
I
N
-
L
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
85.83
33%
-86
- C1 -
3C4J
3
?
A:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-
F
D
E
-----
G
E
I
I
I
D
G
I
N
-
L
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
85.81
33%
-92
- C1 -
3C41
3
?
K:
[22-239]
---------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
TF
L
R
C
L
N
L
L
E
D
-
F
D
E
-----
G
E
I
I
I
D
G
I
N
-
L
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
85.07
33%
-91
- C1 -
2OLK
1
?
D:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
TF
L
R
C
L
N
L
L
E
D
-
F
D
E
-----
G
E
I
I
I
D
G
I
N
-
L
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
84.78
33%
-90
- C1 -
2OLJ
3
?
B:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
TF
L
R
C
L
N
L
L
E
D
-
F
D
E
-----
G
E
I
I
I
D
G
I
N
-
L
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
84.28
33%
-91
- C1 -
2OLK
2
?
B:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
TF
L
R
C
L
N
L
L
E
D
-
F
D
E
-----
G
E
I
I
I
D
G
I
N
-
L
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
84.03
33%
-87
- C1 -
2Q0H
4
?
B:
[39-260]
-----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
-
F
D
E
-----
G
E
I
I
I
D
G
I
N
-
L
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
81.48
31%
-88
- C1 -
4YMV
1
?
J:
[20-237]
---------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
--
T
L
L
R
C
I
----
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
-
I
N
N
G
K
V
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
-
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
---
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
----------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
80.63
31%
-86
- C1 -
4YMU
2
?
J:
[20-237]
---------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
--
T
L
L
R
C
I
----
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
-
I
N
N
G
K
V
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
-
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
---
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
----------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
80.58
31%
-85
- C1 -
4YMU
2
?
A:
[20-237]
---------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
--
T
L
L
R
C
I
----
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
-
I
N
N
G
K
V
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
-
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
---
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
----------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
80.00
31%
-85
- C1 -
4YMV
1
?
A:
[20-237]
---------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
--
T
L
L
R
C
I
----
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
-
I
N
N
G
K
V
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
-
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
---
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
----------------------------------------------------------------------------------------------------------------