@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0130: (2015-12-12 )
METLHNALLKWYEEFGRKDLPFRNLKGINAPYEVYISEVMSQQTQISTVIERFYPPFLKAFPTLKDLANAPLEEVLLLWRGLGYYSRAKNLKKSAEICVKEHHSQLPNDYQSLLKLPGIGAYTANAILCFGFREKSACVDANVKRVLLRLFGLDPNIHAKDLQIKANDFLNLNESFNHNQALIDLGALICSPKPKCAICPFNPYCLGKNHLERHTLKKKQEIIQEERYLGVVIQNNQIALEKIEQKLYLGMHHFPNLKENLEFKLPFLGTIKHSHTKFKLNLNLYLATTKDLKNPIRFYSLKDLETLPISSMTLKILNFLKQKNLFGG
Atome Classification :
(20 SA)
-.........10........20...-----.-----....30........40........50........60........70........80.....-...90........100.......110...-....120.......130.......140.......150......---.----.----.160--.........170.....-------..180.......190.-.-......200.......210.........220.......230.-.-.....240..-.....-250.....-------..260-------..-------------------.....270.......280.......290--........300.......310.......320......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-ME
T
L
H
N
A
L
L
K
W
Y
E
E
FGRKDLPFRN-----L-----KGINA
P
Y
E
V
Y
I
S
E
V
M
SQQ
T
Q
I
S
T
V
I
E
R
FY
P
P
F
L
K
A
F
P
T
L
K
D
L
A
NA
P
L
E
E
V
L
L
L
W
RGL
G
Y
Y
S
-
R
A
K
N
L
K
K
S
A
E
I
C
V
K
E
H
H
S
QL
P
N
D
Y
Q
S
L
LK-LPGIGAYTA
N
A
I
L
C
F
GFREKSACV
D
A
N
V
K
R
V
L
L
R
L
--FGLDPN---I----H----
A
K
----
D
L
Q
I
K
AN
D
F
LNLNESFN-------H
N
Q
A
L
I
D
L
G
A
L
ICS-P-K-P
K
C
A
ICPFNPYCLG
K
N
H
--
L
E
R
H
T
L
K
K
K
Q
E
I
I
Q
EE
R
Y
L
G
V
V
I
-Q-NN
Q
I
A
L
E
K
I
E
-
Q
K
L
Y
L
-
G
M
HHFPN
L
-------
K
EN
L
E
-------
F
K-------------------L
P
F
L
G
T
IKHS
H
T
K
F
K
L
N
L
N
L
Y
L
A
T
T
K
D---LKNP
I
R
F
Y
SLKDLETLPI
S
S
M
T
L
K
I
L
N
F
L
K
Q
KNLFGG
48
Fugue
93.13
29%
-97
- C5 -
1RRQ
4
?
A:
[12-362]
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
-
R
R
D
L
P
W
R
K
-----
D
-----
R
D
---
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
-
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
-
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
--
F
L
V
T
D
D
---
I
----
A
KCS
T
R
K
----
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
-------
F
N
E
A
L
I
E
L
G
A
L
V
C
T
-
P
-
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
--
G
V
A
E
E
L
P
V
K
M
V
K
Q
V
P
L
A
V
A
V
L
A
D
-
D
-
E
G
R
V
L
I
R
K
R
D
-
S
T
G
L
L
A
N
L
W
E
F
P
S
C
ETDGADG
K
E
K
L
E
Q
M
VGL
Q
V
E
L
-------------------
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
S
---
25
HHSearch
91.28
29%
-108
* C5 *
3FSP
4
?
A:
[14-362]
--
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
R
-
D
L
P
W
R
K
-----
D
--------
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
-
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
-
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
--
F
L
V
T
D
D
---
I
AK
P
S
T
----
R
K
----
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
-------
F
N
E
A
L
I
E
L
G
A
L
V
C
T
-
P
-
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
GV
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
-
N
L
W
E
F
P
S
C
-------
E
T
D
-
G
-------
A
D
G
K
E
K
L
E
Q
M
V
G
EQYGL
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
GGP
V
E
E
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
S
---
1
PsiBlast_PDB
85.45
43%
-122
- C5 -
1KG7
5
MUTY_ECOLI
A:
[10-210]
--------
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
-----
D
-----
K
---
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
-
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
--
Y
A
V
S
G
W
---
P
----
G
----
K
K
----
E
V
---
A
N
K
L
W
S
L
S
E
Q
V
T
PAVG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
-
K
-
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
--
N
S
W
A
L
Y
P
G
K
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
85.24
42%
-122
- C5 -
1KG5
6
MUTY_ECOLI
A:
[10-210]
--------
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
-----
D
-----
K
---
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
-
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
Q
R
V
L
A
R
C
--
Y
A
V
S
G
W
---
P
----
G
----
K
K
----
E
V
E
---
N
K
L
W
S
L
S
E
Q
V
T
PAVG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
-
K
-
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
--
N
S
W
A
L
Y
P
G
K
K
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
84.85
42%
-119
- C5 -
1KG4
4
MUTY_ECOLI
A:
[10-210]
--------
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
-----
D
-----
K
---
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
-
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
A
R
V
L
A
R
C
--
Y
A
V
S
G
W
---
P
----
G
----
K
K
----
E
V
E
---
N
K
L
W
S
L
S
E
Q
V
T
PAVG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
-
K
-
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
--
N
S
W
A
L
Y
P
G
K
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
84.59
42%
-122
- C5 -
1KG3
7
MUTY_ECOLI
A:
[10-210]
--------
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
-----
D
-----
K
---
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
-
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
--
Y
A
V
S
G
W
---
P
----
G
----
K
K
----
E
V
E
---
N
K
L
W
S
L
S
E
Q
V
T
PAVG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
-
K
-
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
--
N
S
W
A
L
Y
P
G
K
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.41
42%
-119
- C5 -
1KG2
6
MUTY_ECOLI
A:
[10-210]
--------
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
-----
D
-----
K
---
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
-
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
--
Y
A
V
S
G
W
---
P
----
G
----
K
K
----
E
V
E
---
N
K
L
W
S
L
S
E
Q
V
T
PAVG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
-
K
-
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
--
N
S
W
A
L
Y
P
G
K
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
84.29
42%
-122
- C5 -
1WEF
1
MUTY_ECOLI
A:
[10-210]
--------
V
L
D
W
Y
D
K
Y
G
R
A
T
L
P
W
Q
I
-----
D
-----
K
---
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
-
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
--
Y
A
V
S
G
W
---
P
----
G
----
K
K
----
E
V
E
---
N
K
L
W
S
L
S
E
Q
V
T
PAVG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
-
K
-
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
--
N
S
W
A
L
Y
P
G
K
K
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.27
42%
-121
- C5 -
1KG6
8
MUTY_ECOLI
A:
[10-210]
--------
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
-----
D
-----
K
---
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
-
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
R
R
V
L
A
R
C
--
Y
A
V
S
G
W
---
P
----
G
----
K
K
----
E
V
E
---
N
K
L
W
S
L
S
E
Q
V
T
PAVG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
-
K
-
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
--
N
S
W
A
L
Y
P
G
K
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
84.23
40%
-108
- C5 -
1KG2
6
MUTY_ECOLI
A:
[3-224]
-
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
-----
D
--------
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
-
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
--
Y
A
V
S
G
W
---
P
----
G
----
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
-------
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
-
R
-
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
NS
W
A
L
Y
P
G
K
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
84.21
42%
-118
- C5 -
1WEG
4
MUTY_ECOLI
A:
[10-210]
--------
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
-----
D
-----
K
---
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
-
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
A
R
V
L
A
R
C
--
Y
A
V
S
G
W
---
P
----
G
----
K
K
----
E
V
E
---
N
K
L
W
S
L
S
E
Q
V
T
PAVG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
-
K
-
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
--
N
S
W
A
L
Y
P
G
K
K
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
83.98
42%
-117
- C5 -
1MUD
4
MUTY_ECOLI
A:
[10-210]
--------
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
-----
D
-----
K
---
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
-
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
N
G
N
V
K
R
V
L
A
R
C
--
Y
A
V
S
G
W
---
P
----
G
----
K
K
----
E
V
E
---
N
K
L
W
S
L
S
E
Q
V
T
PAVG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
-
K
-
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
--
N
S
W
A
L
Y
P
G
K
K
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
83.65
42%
-118
- C5 -
1MUN
7
MUTY_ECOLI
A:
[10-210]
--------
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
-----
D
-----
K
---
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
-
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
N
G
N
V
K
R
V
L
A
R
C
--
Y
A
V
S
G
W
---
P
----
G
----
K
K
----
E
V
E
---
N
K
L
W
S
L
S
E
Q
V
T
PAVG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
-
K
-
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
--
N
S
W
A
L
Y
P
G
K
K
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.61
42%
-120
- C5 -
1MUY
4
MUTY_ECOLI
A:
[10-210]
--------
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
-----
D
-----
K
---
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
-
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
--
Y
A
V
S
G
W
---
P
----
G
----
K
K
----
E
V
E
---
N
K
L
W
S
L
S
E
Q
V
T
PAVG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
-
K
-
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
--
N
S
W
A
L
Y
P
G
K
K
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
82.19
37%
-110
- C5 -
3N5N
2
MUTYH_HUMAN
Y:
[15-239]
-
V
T
A
F
R
G
S
L
L
S
W
Y
D
Q
E
-
K
R
D
L
P
W
R
R
RAEDE
M
-----
D
L
D
R
R
A
Y
A
V
W
V
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
N
-
Y
Y
T
G
W
M
Q
K
W
P
T
L
Q
D
L
A
S
A
S
L
E
E
V
N
Q
L
W
A
G
L
G
Y
Y
S
-
R
G
R
R
L
Q
E
G
A
R
K
V
V
E
E
L
G
G
H
M
P
R
T
A
E
T
L
Q
Q
L
L
P
G
V
G
R
Y
T
A
G
A
I
A
S
I
A
F
G
Q
A
T
G
V
V
D
G
N
V
A
R
V
L
C
R
V
RA
I
G
A
D
P
S
ST-
L
----
V
----
S
Q
----
Q
L
W
G
L
A
Q
Q
L
V
D
P
A
R
P
G
D
-------
F
N
Q
A
A
M
E
L
G
A
T
V
C
T
-
P
Q
R
-
P
L
C
S
Q
C
P
V
E
S
L
C
R
A
R
Q
R
--
V
E
Q
E
Q
L
L
A
S
G
S
L
S
V
E
E
C
A
P
N
T
G
Q
-
C
-
H
L
C
L
P
P
S
E
P
W
-
D
Q
T
L
G
-
V
V
N
----------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
81.58
42%
-117
- C5 -
1KQJ
5
MUTY_ECOLI
A:
[10-210]
--------
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
-----
D
-----
K
---
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
-
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
--
Y
A
V
S
G
W
---
P
----
G
----
K
K
----
E
V
E
---
N
K
L
W
S
L
S
E
Q
V
T
PAVG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
-
K
-
P
K
H
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
--
N
S
W
A
L
Y
P
G
K
K
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
80.05
42%
-114
- C5 -
1WEI
5
MUTY_ECOLI
A:
[10-210]
--------
V
L
D
W
Y
D
K
Y
G
R
A
T
L
P
W
Q
I
-----
D
-----
K
---
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
-
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
---
Y
A
V
S
G
W
---
P
----
G
----
K
K
----
E
V
E
---
N
K
L
W
-
L
S
E
Q
V
T
PAVG
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
-
C
T
R
S
-
K
-
P
K
C
-
L
C
P
L
Q
N
G
C
I
A
A
A
N
--
N
S
W
A
L
Y
P
G
K
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
77.02
40%
-102
- C5 -
3N5N
1
MUTYH_HUMAN
X:
[16-233]
--
T
A
F
R
G
S
L
L
S
W
Y
D
Q
E
K
R
-
D
L
P
W
R
R
-----
R
AEDEM
D
L
D
R
R
A
Y
A
V
W
V
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
N
-
Y
Y
T
G
W
M
Q
K
W
P
T
L
Q
D
L
A
S
A
S
L
E
E
V
N
Q
L
W
A
G
L
G
Y
Y
S
-
R
G
R
R
L
Q
E
G
A
R
K
V
V
E
E
L
G
G
H
M
P
R
T
A
E
T
L
Q
Q
L
L
P
G
V
G
R
Y
T
A
G
A
I
A
S
I
A
F
G
Q
A
T
G
V
V
D
G
N
V
A
R
V
L
C
R
V
--
R
A
I
G
A
D
---
P
SSTL
V
----
S
Q
----
Q
L
W
G
L
A
Q
Q
L
V
D
P
A
R
P
G
D
-------
F
N
Q
A
A
M
E
L
G
A
T
V
C
T
-
P
-
Q
R
P
L
C
S
Q
C
P
V
E
S
L
C
R
A
R
Q
R
--
V
E
Q
E
Q
L
L
A
S
G
S
L
V
E
E
C
A
P
N
T
G
Q
C
-
H
-
L
C
L
P
P
S
E
P
W
D
-
Q
T
L
G
V
-
V
N
-----------------------------------------------------------------------------------------------------------------
28
HHSearch
76.85
29%
-112
- C5 -
1KEA
8
GTMR_METTF
A:
[10-218]
--
K
V
F
V
S
T
I
L
T
F
W
N
T
D
R
R
-
D
F
P
W
R
H
-----
T
--------
R
D
P
Y
V
I
L
I
T
E
I
L
L
R
R
T
T
A
G
H
V
K
K
-
I
Y
D
K
F
F
V
K
Y
K
C
F
E
D
I
L
K
T
P
K
S
E
I
A
K
D
I
K
E
I
G
L
S
N
Q
R
A
E
Q
L
K
E
L
A
R
V
V
I
N
D
Y
G
G
R
V
P
R
N
R
K
A
I
L
D
-
L
P
G
V
G
K
Y
T
C
A
A
V
M
C
L
A
F
G
K
K
A
A
M
V
D
A
N
F
V
R
V
I
N
R
Y
--
F
G
G
S
Y
E
NLN
Y
----
N
----
H
K
----
A
L
W
E
L
A
E
T
L
V
P
G
G
K
C
R
D
-------
F
N
L
G
L
M
D
F
S
A
I
I
C
A
-
P
-
R
K
P
K
C
E
K
C
G
M
S
K
L
C
S
Y
Y
E
K
--
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
76.80
37%
-104
- C5 -
3N5N
1
MUTYH_HUMAN
X:
[15-239]
-
V
T
A
F
R
G
S
L
L
S
W
Y
D
Q
E
-
K
R
D
L
P
W
R
R
RAEDE
M
-----
D
L
D
R
R
A
Y
A
V
W
V
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
N
-
Y
Y
T
G
W
M
Q
K
W
P
T
L
Q
D
L
A
S
A
S
L
E
E
V
N
Q
L
W
A
G
L
G
Y
Y
S
-
R
G
R
R
L
Q
E
G
A
R
K
V
V
E
E
L
G
G
H
M
P
R
T
A
E
T
L
Q
Q
L
L
P
G
V
G
R
Y
T
A
G
A
I
A
S
I
A
F
G
Q
A
T
G
V
V
D
G
N
V
A
R
V
L
C
R
V
RA
I
G
A
D
P
S
ST-
L
----
V
----
S
Q
----
Q
L
W
G
L
A
Q
Q
L
V
D
P
A
R
P
G
D
-------
F
N
Q
A
A
M
E
L
G
A
T
V
C
T
-
P
Q
R
-
P
L
C
S
Q
C
P
V
E
S
L
C
R
A
R
Q
R
--
V
E
Q
E
Q
L
L
A
S
G
S
L
V
E
E
C
A
P
N
T
G
Q
C
-
H
-
L
C
L
P
P
S
E
P
W
D
-
Q
T
L
G
V
-
V
N
-----------------------------------------------------------------------------------------------------------------