@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0223: (2015-12-13 )
MLFSKLFAPTLKEPPKDAVLKSPKHPGKAGYIYQIGSGIYNFLPLAKKVLDKIENVTHKRMQEHGAQNILMSFVVLASLWEKSGRLDKYGKELLVFKDRKDNDFVLSPTLEENITEIAANFIKSYKQLPVHLYQIHTKFRDEIRPRFGLVRAREFIMKDGYSFHEDAESLDKEFLNTQSAYKEILSDLGLDFRIVEADSGAIGGSKSREFVVLTECGEDTIVVCQNCDYAANIEIAKRSKRTEPLMSPSALAKFPTPNTTSAPSVAEFFKTEPYFVLKALVNKVIHKDKETLACFFVRGDDNLEETKALNTLNLLGANALELREANEEDLNKAGLIAGFIGPYGLKKHVCYIIFDEDLKEGDCLIVGANEKDFHAVGVDLKGFENLVYADIVQVKESDCCPNCQGALKYHKSLEVGHIFKLGQSYAKSLKASFLDKNGKERFFEMGCYGIGISRLLSVILEQKSDDLGCVWTKNTAPFDVVIVVSNLKDEAQKKLAFEVYERLLQKGVDALLDDRDARFGAKMRDFELIGERLALIVGKQTLESKEFECIKRANLEKQTIKDIELEEKILEMLASE
Atome Classification :
(20 SA)
.........10........20..-....-..-30..------------.---.------.-...40........50........60-..--......70........80-.-.-.......90.......-.---------------------------------------------------------------------------------100--.........110.......120--..-....---..130.......140...-..-..150....-...160.......170----------------------------------------....---....180....-.-.--------.-190--.-.......200.......210-........220.......230....------.-..240.-......250.......260.......270.......280.......290.......300.......310..--.....320.......330..-......--340.......350.......360.......370.......380....-....390.......400.......410.......420.......430....-..-.440-..--..--.--...450....-.....460.-.----..--.------.--.470.......480..--.---....---490-----.........500...--------------...-.510...-.-..-.520.....-..530........540.---------......550....--.----..560.......570....-----------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
F
S
K
LFAPTLKEPP
K
D
A
VLKSP-KHPG-KA-
G
Y
I
Y
------------Q---I------
G
-
S
G
I
Y
N
F
L
P
L
A
K
K
V
L
D
K
I
E
N
V
T
H
K
R
M
-
Q
E
--H
G
A
Q
N
I
L
M
S
F
V
V
L
A
S
L
W
--
E
-K-SGR
L
D
K
YGK
E
L
L
V
F
KD-R---------------------------------------------------------------------------------K----DN
D
F
V
LS
P
T
L
E
E
N
I
T
E
I
A
A
N
F
---
I
K
-
S
Y
K
Q---L
P
V
H
L
Y
Q
I
H
T
K
F
R
D
E
I
R
P
-
R
F
-
G
L
V
R
A
R
E
F
I
-
M
KDGYS
F
H
E
D
A
E
S
L
D
-----------------------------------------
K
E
F
L
---
N
T
Q
S
A
Y
K
E
I
L
S
-D-L--------G-L
D
---
F
-
R
I
V
EADSGAIGGSKS
R
E
F
V
--
V
L
TECGE
D
T
I
V
V
CQNCDYAAN
I
E
I
A------K-RSKRTE-PLM
S
P
S
A
L
AKFPTPNTTSA
P
S
V
A
E
F
FKTE
P
Y
F
V
L
K
A
L
V
N
K
V
I
HKDK
E
T
L
A
C
F
F
V
RGDD
N
L
E
E
T
K
AL
N
T
L
N
L--LGAN
A
L
E
LREA
N
E
E
D
L
-
N
K
A-G
L
I
A
GF--IGPYGLK
K
H
V
C
Y
I
I
FDEDLKEG
D
C
L
I
V
GANEK
D
F
H
A
VGVD
L
-
K
GF
E
N
-
L
V
Y
A
D
I
V
Q
VKESDCCPN
C
Q
G
A
L
K
Y
H
KSLEV
G
H
I
F
K
L
G
Q
S
Y
A
K
S
L
K
A
S
F
LDK-NG-K
E
-
R
-
F
F--EM--G--C
Y
G
I
--
G
I
S
R
-
L
L
S
V
I
L
E
QK-S----DD--L------
G
--
C
V
WTKNTA
P
F
D
V
V
I
V
V--S---N
L
K
D
---
E
-------
A
Q
K
K
L
A
F
E
V
Y
E
R
L
L
Q
--------------K
G
V
-
D
A
L
LDDR-D-AR-FGAKM
R
D
F
E
-
L
I
G
E
-
R
L
A
L
I
VGKQTL
E
---------
S
K
E
F
E
C
I
K
R
ANLE--
K
----
Q
T
I
K
D
I
E
L
E
E
K
I
L
E
M
LASE-----------------------------------------------------------------------------------------
63
Fugue
97.51
41%
-78
- C1 -
2J3L
11
SYP_ENTFA
A:
[1-565]
M
K
Q
S
K
M
L
I
P
T
L
R
E
V
P
N
D
A
E
V
L
S
H
-
Q
I
L
L
-
R
A
-
G
Y
I
R
------------
Q
---
V
------
A
-
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
-
E
K
--
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
--
K
-
E
-
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
D
-
R
---------------------------------------------------------------------------------
N
----
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
---
I
N
-
S
Y
K
R
---
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
-
R
S
-
G
L
L
R
G
R
E
F
I
-
M
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
-----------------------------------------
Q
S
Y
R
---
D
Y
E
K
A
Y
S
R
I
F
E
-
R
-
C
--------
G
-
L
E
---
F
-
R
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
--
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
D
Y
A
A
N
L
E
M
A
------
T
S
L
Y
T
P
K
K
-
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
V
L
F
I
A
----
D
E
E
P
V
M
V
L
V
R
G
D
H
D
V
N
D
V
K
L
K
N
F
L
G
-------
A
D
F
L
D
E
A
T
E
E
D
A
-
R
R
V
L
G
A
G
F
G
S
--
I
G
P
V
N
V
S
E
D
V
-
K
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
-
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
-
N
G
-
R
E
-
K
-
S
V
--
I
M
--
G
--
C
Y
G
I
--
G
V
S
R
-
L
L
S
A
I
V
E
Q
N
-
A
----
D
E
--
R
------
G
--
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
--
M
---
N
V
K
D
---
E
-------
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
--------------
A
G
Y
-
E
V
L
V
D
D
R
-
N
-
E
R
-
A
G
V
K
F
A
D
A
D
-
L
I
G
C
-
P
I
R
I
T
V
G
K
K
A
V
D
----------
G
V
V
E
V
K
I
K
R
T
G
E
--
M
----
L
E
V
R
K
E
E
L
E
S
T
L
S
I
L
M
--------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.43
41%
-77
- C1 -
2J3L
11
SYP_ENTFA
A:
[1-561]
M
K
Q
S
K
M
L
I
P
T
L
R
E
V
P
N
D
A
E
V
L
S
H
-
Q
I
L
L
-
R
A
-
G
Y
I
R
------------
Q
---
V
------
A
-
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
-
E
K
--
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
--
K
-
E
-
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
D
-
R
---------------------------------------------------------------------------------
N
----
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
---
I
N
-
S
Y
K
R
---
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
-
R
S
-
G
L
L
R
G
R
E
F
I
-
M
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
-----------------------------------------
Q
S
Y
R
---
D
Y
E
K
A
Y
S
R
I
F
E
-
R
-
C
--------
G
-
L
E
---
F
-
R
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
--
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
D
Y
A
A
N
L
E
M
A
TSLYTP
K
-
K
S
H
E
T
Q
------
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
----
V
L
F
I
A
D
E
E
P
V
M
V
L
V
R
G
D
H
D
V
N
D
V
K
---
L
K
N
F
--
L
G
A
D
F
L
D
--
E
A
T
E
E
D
A
-
R
R
V
--
L
G
A
G
F
GS
I
G
P
V
N
V
S
E
D
V
K
-
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
-
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
-
N
G
-
R
E
-
K
-
S
V
--
I
M
--
G
--
C
Y
G
I
--
G
V
S
R
-
L
L
S
A
I
V
E
Q
N
-
A
----
D
E
--
R
------
G
--
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
--
M
---
N
V
K
D
---
E
-------
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
--------------
A
G
Y
-
E
V
L
V
D
D
R
-
N
-
E
R
-
A
G
V
K
F
A
D
A
D
-
L
I
G
C
-
P
I
R
I
T
V
G
K
K
A
V
D
---------
G
V
V
E
V
K
I
K
R
T
G
-
E
--
M
----
L
E
V
R
K
E
E
L
E
S
T
L
S
I
L
M
--------------------------------------------------------------------------------------------
22
PsiBlast_CBE
96.76
41%
-77
- C1 -
2J3L
13
SYP_ENTFA
B:
[1-561]
M
K
Q
S
K
M
L
I
P
T
L
R
E
V
P
N
D
A
E
V
L
S
H
-
Q
I
L
L
-
R
A
-
G
Y
I
R
------------
Q
---
V
------
A
-
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
-
E
K
--
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
--
K
-
E
-
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
D
-
R
---------------------------------------------------------------------------------
N
----
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
---
I
N
-
S
Y
K
R
---
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
-
R
S
-
G
L
L
R
G
R
E
F
I
-
M
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
-----------------------------------------
Q
S
Y
R
---
D
Y
E
K
A
Y
S
R
I
F
E
-
R
-
C
--------
G
-
L
E
---
F
-
R
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
--
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
D
Y
A
A
N
L
E
M
A
TSLYTP
K
-
K
S
H
E
T
Q
------
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
----
V
L
F
I
A
D
E
E
P
V
M
V
L
V
R
G
D
H
D
V
N
D
V
K
---
L
K
N
F
--
L
G
A
D
F
L
D
--
E
A
T
E
E
D
A
-
R
R
V
--
L
G
A
G
F
GS
I
G
P
V
N
V
S
E
D
V
K
-
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
-
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
-
N
G
-
R
E
-
K
-
S
V
--
I
M
--
G
--
C
Y
G
I
--
G
V
S
R
-
L
L
S
A
I
V
E
Q
N
-
A
----
D
E
--
R
------
G
--
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
--
M
---
N
V
K
D
---
E
-------
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
--------------
A
G
Y
-
E
V
L
V
D
D
R
-
N
-
E
R
-
A
G
V
K
F
A
D
A
D
-
L
I
G
C
-
P
I
R
I
T
V
G
K
K
A
V
D
---------
G
V
V
E
V
K
I
K
R
T
G
-
E
--
M
----
L
E
V
R
K
E
E
L
E
S
T
L
S
I
L
M
N
T
T
-----------------------------------------------------------------------------------------
2
PsiBlast_PDB
96.46
41%
-78
- C1 -
2J3M
5
SYP_ENTFA
A:
[1-561]
M
K
Q
S
K
M
L
I
P
T
L
-------
E
V
L
S
H
-
Q
I
L
L
-
R
A
-
G
Y
I
R
------------
Q
---
V
------
A
-
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
-
E
K
--
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
--
K
-
E
-
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
D
-
R
---------------------------------------------------------------------------------
N
----
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
---
I
N
-
S
Y
K
R
---
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
-
R
S
-
G
L
L
R
G
R
E
F
I
-
M
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
-----------------------------------------
Q
S
Y
R
---
D
Y
E
K
A
Y
S
R
I
F
E
-
R
-
C
--------
G
-
L
E
---
F
-
R
A
I
I
G
D
G
----
G
K
D
S
K
E
F
M
--
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
D
Y
A
A
N
L
E
M
A
T
S
L
Y
T
P
K
-
K
S
H
E
T
Q
------
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
----
V
L
F
I
A
D
E
E
P
V
M
V
L
V
R
G
D
H
D
V
N
D
V
K
---
L
K
N
F
--
L
G
A
D
F
L
D
--
E
A
T
E
E
D
A
-
R
R
V
--
L
G
A
G
F
GS
I
G
P
V
N
V
S
E
D
V
K
-
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
-
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
-
N
G
-
R
E
-
K
-
S
V
--
I
M
--
G
--
C
Y
G
I
--
G
V
S
R
-
L
L
S
A
I
V
E
Q
N
-
A
----
D
E
--
R
------
G
--
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
--
M
---
N
V
K
D
---
E
-------
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
--------------
A
G
Y
-
E
V
L
V
D
D
R
-
N
-
E
R
-
A
G
V
K
F
A
D
A
D
-
L
I
G
C
-
P
I
R
I
T
V
G
K
K
A
V
D
---------
G
V
V
E
V
K
I
K
R
T
G
-
E
--
M
----
L
E
V
R
K
E
E
L
E
S
T
L
S
I
L
M
--------------------------------------------------------------------------------------------
42
HHSearch
96.28
41%
-75
- C1 -
2J3L
11
SYP_ENTFA
A:
[1-565]
M
K
Q
S
K
M
L
I
P
T
L
R
E
V
P
N
D
A
E
V
L
S
H
-
Q
I
L
L
-
R
A
-
G
Y
I
R
------------
Q
---
V
------
A
-
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
-
E
K
--
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
--
K
-
E
-
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
D
-
R
---------------------------------------------------------------------------------
N
----
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
---
I
N
-
S
Y
K
R
---
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
-
R
S
-
G
L
L
R
G
R
E
F
I
-
M
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
-----------------------------------------
Q
S
Y
R
---
D
Y
E
K
A
Y
S
R
I
F
E
-
R
-
C
--------
G
-
L
E
---
F
-
R
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
--
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
D
Y
A
A
N
L
E
M
A
------
T
-
S
L
Y
T
P
K
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
V
L
F
I
A
----
D
E
E
P
V
M
V
L
V
R
G
D
H
D
V
N
D
V
K
L
K
N
F
L
G
A
--
D
F
L
-----
D
E
A
T
E
E
D
A
R
R
V
L
-
G
A
G
F
G
S
--
I
G
P
V
N
V
S
E
D
V
K
I
Y
A
-
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
-
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
-
N
G
-
R
E
-
K
-
S
V
--
I
M
--
G
--
C
Y
G
I
--
G
V
S
R
-
L
L
S
A
I
V
E
Q
N
-
A
----
D
E
--
R
------
G
--
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
--
M
---
N
V
K
D
---
E
-------
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
--------------
A
G
Y
-
E
V
L
V
D
D
R
-
N
-
E
R
-
A
G
V
K
F
A
D
A
D
-
L
I
G
C
-
P
I
R
I
T
V
G
K
K
A
V
----------
D
G
V
V
E
V
K
I
K
R
T
G
E
--
M
----
L
E
V
R
K
E
E
L
E
S
T
L
S
I
L
M
--------------------------------------------------------------------------------------------
21
PsiBlast_CBE
95.98
41%
-75
- C1 -
2J3M
5
SYP_ENTFA
B:
[1-561]
M
K
Q
S
K
M
L
I
P
T
L
-------
E
V
L
S
H
-
Q
I
L
L
-
R
A
-
G
Y
I
R
------------
Q
---
V
------
A
-
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
-
E
K
--
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
--
K
-
E
-
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
D
-
R
---------------------------------------------------------------------------------
N
----
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
---
I
N
-
S
Y
K
R
---
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
-
R
S
-
G
L
L
R
G
R
E
F
I
-
M
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
-----------------------------------------
Q
S
Y
R
---
D
Y
E
K
A
Y
S
R
I
F
E
-
R
-
C
--------
G
-
L
E
---
F
-
R
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
--
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
D
Y
A
A
N
L
E
M
A
T
S
L
Y
T
P
K
-
K
S
H
E
T
Q
------
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
----
V
L
F
I
A
D
E
E
P
V
M
V
L
V
R
G
D
H
D
V
N
D
V
K
---
L
K
N
F
--
L
G
A
D
F
L
D
--
E
A
T
E
E
D
A
-
R
R
V
--
L
G
A
G
F
GS
I
G
P
V
N
V
S
E
D
V
K
-
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
-
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
-
N
G
-
R
E
-
K
-
S
V
--
I
M
--
G
--
C
Y
G
I
--
G
V
S
R
-
L
L
S
A
I
V
E
Q
N
-
A
----
D
E
--
R
------
G
--
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
--
M
---
N
V
K
D
---
E
-------
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
--------------
A
G
Y
-
E
V
L
V
D
D
R
-
N
-
E
R
-
A
G
V
K
F
A
D
A
D
-
L
I
G
C
-
P
I
R
I
T
V
G
K
K
A
V
D
---------
G
V
V
E
V
K
I
K
R
T
G
-
E
--
M
----
L
E
V
R
K
E
E
L
E
S
T
L
S
I
L
M
--------------------------------------------------------------------------------------------
43
HHSearch
80.69
36%
-62
- C1 -
2I4L
-
SYP_RHOPA
A:
[1-436]
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
-
R
L
M
L
-
R
A
-
G
M
L
R
------------
Q
---
E
------
A
-
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
-
N
R
--
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
--
R
-
E
-
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
D
-
R
---------------------------------------------------------------------------------
H
----
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
---
I
K
-
S
Y
K
S
---
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
-
R
F
-
G
V
M
R
G
R
E
F
L
-
M
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
-----------------------------------------
K
S
Y
N
---
K
M
F
V
A
Y
L
R
T
F
A
-
R
-
M
--------
G
-
L
K
---
A
-
I
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
--
V
L
A
E
T
G
E
S
G
V
Y
I
D
R
D
V
L
---
N
L
P
-------------
V
---------
P
------
D
E
------
N
V
D
Y
D
G
-------------------------------
D
L
-----
T
P
I
I
-----------------
K
Q
W
-----------------------
T
S
V
Y
-
A
-------------
A
T
E
D
V
H
E
------
P
A
R
Y
E
-------------
S
E
V
P
--
E
A
N
R
L
N
T
R
G
I
E
V
G
Q
I
F
Y
F
G
T
K
Y
S
D
S
M
K
A
N
V
T
G
P
-
D
G
-
T
D
-
A
-
P
I
--
H
G
--
G
--
S
Y
G
V
--
G
V
S
R
-
L
L
G
A
I
I
E
A
C
-
H
----
D
D
--
N
------
G
--
I
I
W
P
E
A
V
A
P
F
R
V
T
I
L
N
--
L
---
K
Q
G
D
---
A
-------
A
T
D
A
A
C
D
Q
L
Y
R
E
L
S
A
--------------
K
G
V
-
D
V
L
Y
D
D
T
-
D
-
Q
R
-
A
G
A
K
F
A
T
A
D
-
L
I
G
I
-
P
W
Q
I
H
V
G
P
R
G
L
A
---------
E
G
K
V
E
L
K
R
R
S
D
G
A
--
R
----
E
N
L
A
L
A
D
V
V
A
R
-------------------------------------------------------------------------------------------------
45
HHSearch
70.53
25%
-83
- C1 -
1NJ8
-
SYP_METJA
A:
[5-376]
--------------------
E
W
Y
-
S
D
I
L
E
K
A
-
E
I
Y
D
------------
V
RY-
P
------
I
-
K
G
C
G
V
Y
L
P
Y
G
F
K
I
R
R
Y
T
F
E
I
I
R
N
L
L
-
D
E
--
S
G
H
D
E
A
L
F
P
M
L
I
P
E
D
L
L
--
A
-
K
E
A
E
H
I
K
G
F
E
D
E
V
Y
W
V
T
H
-
G
---------------------------------------------------------------------------------
G
KTQL
D
V
K
L
A
L
R
P
T
S
E
T
P
I
Y
Y
M
M
K
L
W
---
V
K
-
V
H
T
D
---
L
P
I
K
I
Y
Q
I
V
N
T
F
R
Y
E
T
K
H
-
T
R
-
P
L
I
R
L
R
E
I
M
T
F
K
E
A
H
T
A
H
S
T
K
E
E
A
E
-----------------------------------------
N
Q
V
K
---
E
A
I
S
I
Y
K
K
F
F
D
-
T
-
L
--------
G
-
I
P
---
Y
-
L
I
S
K
R
P
----------------------------------------------------------
E
W
D
K
---
F
--
P
-------------------------------------------------------
G
A
----------------------------
E
--
Y
T
M
A
-----
F
D
T
I
-------------------------------------------------
F
P
-------
D
G
R
T
M
Q
I
A
T
V
H
N
L
G
Q
N
F
S
K
T
F
E
I
I
F
E
T
P
-
T
G
-
D
K
-
D
-
Y
A
--
Y
Q
--
T
--
C
Y
G
I
--
S
-
D
R
-
V
I
A
S
I
I
A
I
H
-
G
----
D
E
--
K
------
G
--
L
I
L
P
P
I
V
A
P
I
Q
V
V
I
V
P
--
L
---
I
F
K
G
K
E
-
D
-------
I
V
M
E
K
A
K
E
I
Y
E
K
L
K
---------------
G
K
F
-
R
V
H
I
D
D
R
-
D
-
I
R
-
P
G
R
K
F
N
D
W
E
-
I
K
G
V
-
P
L
R
I
E
V
G
P
K
D
I
E
---------
N
K
K
I
T
L
F
R
R
D
T
M
E
--
K
----
F
Q
V
D
E
T
Q
L
M
E
V
V
E
K
T
L
N
N
I
-----------------------------------------------------------------------------------------
46
HHSearch
68.41
22%
-75
- C1 -
3IAL
5
?
A:
[26-399]
--------------------
D
W
F
-
D
A
I
M
-
D
A
A
E
L
V
D
------------
R
RY-
P
------
V
-
K
G
C
V
V
F
R
P
Y
G
F
F
M
E
N
A
I
M
R
L
C
E
E
E
Y
-
A
K
--
V
G
I
S
Q
I
L
F
P
T
V
I
P
E
S
F
L
--
K
K
E
-
S
D
H
I
K
G
F
E
A
E
C
F
W
V
E
K
-
G
GLQP-----------------------------------------------------------------------------
L
----
E
E
R
L
A
L
R
P
T
S
E
T
A
I
Y
S
M
F
S
K
W
---
V
R
-
S
Y
K
D
---
L
P
L
K
I
H
Q
T
C
T
I
F
R
H
E
T
K
N
-
T
K
-
P
L
I
R
V
R
E
I
H
-
W
N
E
A
H
C
C
H
A
T
A
E
D
A
V
-----------------------------------------
S
Q
L
S
---
D
Y
W
K
V
I
D
T
I
F
S
D
E
-
L
--------
C
-
F
K
---
G
-
Q
K
L
R
R
---------------------------
V
C
-------------------------------
W
D
R
------------------------------------------------------------
F
P
----------------------------
G
A
D
--
Y
S
E
V
-----
S
D
V
V
M
-------------------------------------------------
P
-
C
------
G
R
V
L
Q
T
A
G
I
H
N
L
G
Q
R
F
S
S
T
F
D
I
L
Y
A
N
K
-
A
N
-
E
S
-
V
-
H
P
--
Y
L
--
T
--
C
A
G
I
--
S
-
T
R
-
V
L
A
C
A
L
S
I
H
-
G
----
D
S
--
G
------
G
--
L
V
L
P
P
L
I
A
P
I
H
V
V
I
I
P
--
I
---
G
C
G
K
---
K
NN
Q
E
S
D
Q
Q
V
L
G
K
V
N
E
I
A
D
T
L
K
S
K-------------
L
G
L
-
R
V
S
I
D
D
D
F
S
-
K
S
-
M
G
D
K
L
Y
Y
Y
E
-
L
K
G
V
-
P
L
R
I
E
V
G
Q
R
D
L
A
---------
N
G
Q
C
I
V
V
P
R
D
V
G
K
DQ
K
----
R
V
I
P
I
T
E
V
M
K
V
S
V
V
K
N
V
I
K
-----------------------------------------------------------------------------------------
44
HHSearch
68.33
23%
-75
* C1 *
1NJ1
2
SYP_METTH
A:
[41-413]
------------------
S
E
W
F
H
-
N
I
L
E
-
E
A
-
E
I
I
D
------------
Q
RY-
P
------
V
-
K
G
M
H
V
W
M
P
H
G
F
M
I
R
K
N
T
L
K
I
L
R
R
I
L
-
D
---
R
D
H
E
E
V
L
F
P
L
L
V
P
E
D
E
L
--
A
K
E
-
A
I
H
V
K
G
F
E
D
E
V
Y
W
V
T
H
-
G
GLSK-----------------------------------------------------------------------------
L
----
Q
R
K
L
A
L
R
P
T
S
E
T
V
M
Y
P
M
F
A
L
W
---
V
R
-
S
H
T
D
---
L
P
M
R
F
Y
Q
V
V
N
T
F
R
Y
E
T
K
H
-
T
R
-
P
L
I
R
V
R
E
I
T
T
F
K
E
A
H
T
I
H
A
T
A
S
E
A
E
-----------------------------------------
E
Q
V
E
---
R
A
V
E
I
Y
K
E
F
F
N
-
S
-
L
--------
G
-
I
P
---
Y
-
L
I
T
R
R
P
P
----------------------------------------------------------
W
D
K
---
F
---------------------------------------------------------
P
G
S
--
E
----------------------------
Y
T
-------
V
A
F
D
-----------------------------------------------
T
L
M
P
D
-------
G
K
T
L
Q
I
G
T
V
H
N
L
G
Q
T
F
A
R
T
F
E
I
K
F
E
T
P
-
E
G
-
D
H
-
E
-
Y
V
--
H
Q
--
T
--
C
Y
G
L
--
S
-
D
R
-
V
I
A
S
V
I
A
I
H
-
G
----
D
E
--
S
------
G
--
L
C
L
P
P
D
V
A
A
H
Q
V
V
I
V
P
--
I
---
I
F
K
K
A
A
-
E
-------
E
V
M
E
A
C
R
E
L
R
S
R
L
E
A
--------------
A
G
F
-
R
V
H
L
D
D
R
-
D
-
I
R
-
A
G
R
K
Y
Y
E
W
E
-
M
R
G
V
-
P
L
R
V
E
I
G
P
R
D
L
E
---------
K
G
A
A
V
I
S
R
R
D
T
G
E
--
K
----
V
T
A
D
L
Q
G
I
E
E
T
L
R
E
L
M
K
D
I
-----------------------------------------------------------------------------------------
47
HHSearch
67.95
22%
-76
- C1 -
1HC7
-
SYP_THET8
A:
[13-386]
-----------------
D
F
S
E
W
Y
-
L
E
V
I
-
Q
K
A
E
L
A
D
------------
Y
G
--
P
------
V
-
R
G
T
I
V
V
R
P
Y
G
Y
A
I
W
E
N
I
Q
Q
V
L
D
R
M
F
-
K
E
--
T
G
H
Q
N
A
Y
F
P
L
F
I
P
M
S
F
L
------------
F
S
P
E
L
A
V
V
T
H
-
A
---------------------------------------------------------------------------------
G
GEEL
E
E
P
L
A
V
R
P
T
S
E
T
V
I
G
Y
M
W
S
K
W
---
I
R
-
S
W
R
D
---
L
P
Q
L
L
N
Q
W
G
N
V
V
R
W
E
M
R
--
T
R
-
P
F
L
R
T
S
E
F
L
-
W
Q
E
G
H
T
A
H
A
T
R
E
E
A
E
-----------------------------------------
E
E
V
R
---
R
M
L
S
I
Y
A
R
L
A
R
-
E
-
Y
--------
A
A
I
P
---
V
-
I
E
--------
G
----------------
L
-----
K
T
-----------------------------
E
K
E
K
------------------------------------------------------------
F
A
G
----------------------------
A
V
--
Y
T
T
T
-----
I
E
A
L
--------------------------------------------------------
M
K
D
G
K
A
L
Q
A
G
T
S
H
Y
L
G
E
N
F
A
R
A
F
D
I
K
F
Q
D
R
-
D
L
-
Q
V
-
K
-
Y
V
--
H
T
--
T
--
S
W
G
L
--
S
-
W
R
-
F
I
G
A
I
I
M
T
H
-
G
----
D
D
--
R
------
G
--
L
V
L
P
P
R
L
A
P
I
Q
V
V
I
V
P
--
I
---
Y
K
D
E
S
R
-
E
-------
R
V
L
E
A
A
Q
G
L
R
Q
A
L
L
A
--------------
Q
G
L
-
R
V
H
L
D
D
R
-
D
Q
H
T
-
P
G
Y
K
F
H
E
W
E
-
L
K
G
V
-
P
F
R
V
E
L
G
P
K
D
L
E
---------
G
G
Q
A
V
L
A
S
R
L
G
G
---
K
----
E
T
L
P
L
A
A
L
P
E
A
L
P
G
K
L
D
A
F
-----------------------------------------------------------------------------------------
50
HHSearch
67.29
19%
-72
- C1 -
3UH0
3
SYTM_YEAST
A:
[31-458]
----------------
A
T
P
A
T
M
T
-
S
M
V
S
-
Q
R
Q
D
L
F
M
------------
T
D
P-
L
------
S
-
P
G
S
M
F
F
L
P
N
G
A
K
I
F
N
K
L
I
E
F
M
K
L
Q
Q
K
F
K
--
F
G
F
N
E
V
V
T
P
L
I
Y
K
K
T
L
W
--
E
-
K
-
S
G
H
W
E
N
Y
A
D
D
M
F
K
V
E
T
------------------------------------------------------------------------------------------
E
Y
G
L
K
P
M
N
C
P
G
H
C
L
I
F
G
K
K
---
D
R
-
S
Y
N
E
---
L
P
L
R
F
S
D
F
S
P
L
H
R
N
E
A
S
G
A
L
S
-
G
L
T
R
L
R
K
F
H
-
Q
D
D
G
H
I
F
C
T
P
S
-
Q
V
K
-----------------------------------------
S
E
I
F
---
N
S
L
K
L
I
D
I
V
Y
N
-
K
I
F
--------
P
-
F
V
-------------
A
E
S
----
N
Y
F
I
--
N
F
S
T
R
P
D
---------
H
F
I
G
D
--------------------
L
K
V
W
N
H
A
----------------------
E
Q
V
L
K
E
I
L
E
E
----------------------------
S
G
K
--
P
--------------
W
-
K
L
N
-
P
G
D
G
A
F
--
Y
G
P
K
-----
L
D
I
M
V
T
D
-----------------------
H
-------------------------------
L
R
K
T
H
Q
V
A
T
I
-
Q
L
D
F
Q
L
P
E
R
F
D
L
K
F
K
D
Q
-
D
N
-
S
Y
K
R
-
P
I
M
I
H
R
--
A
--
T
F
G
---
S
I
E
R
-
F
M
A
L
L
I
D
S
N
-----------------
E
--
G
R
W
P
F
W
L
N
P
Y
Q
A
V
I
I
P
--
V
---
N
T
K
N
---
V
-------
Q
Q
L
D
M
C
T
A
L
Q
K
K
L
R
N
ELEADDMEPVPLN
D
W
H
F
-
N
V
D
L
D
I
R
-
N
-
E
P
-
V
G
Y
R
I
K
S
A
I
-
L
K
N
Y
-
S
Y
L
I
I
V
G
D
E
E
V
Q
---------
L
Q
K
Y
N
I
R
E
R
D
N
R
K
--
S
F
---
E
K
L
T
M
S
Q
I
W
E
K
F
I
E
L
E
K
N
Y
-----------------------------------------------------------------------------------------
49
HHSearch
66.59
18%
-55
- C1 -
1NYR
3
SYT_STAAW
A:
[236-640]
---------------
E
E
R
K
E
R
D
H
-
R
K
I
G
-
K
E
L
E
L
F
T
------------
N
SQL
V
------
G
-
A
G
L
P
L
W
L
P
N
G
A
T
I
R
R
E
I
E
R
Y
I
V
D
K
E
-
V
S
--
M
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
--
K
-
T
-
S
G
H
W
D
H
Y
Q
E
D
M
F
P
P
M
Q
L
D
---------------------------------------------------------------------------------
E
----
T
E
S
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
---
P
H
-
S
Y
R
E
---
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
-
G
L
Q
R
V
R
G
M
T
-
L
N
D
S
H
I
F
V
R
P
D
-
Q
I
K
-----------------------------------------
E
E
F
K
---
R
V
V
N
M
I
I
D
V
Y
K
-
D
-
F
--------
G
-
F
E
D
--
Y
-
S
F
R
L
S
Y
-
R
D
P
E
D
--
K
E
K
Y
F
-------
D
D
----------------------------------
D
D
M
W
N
K
----------------------
A
E
N
M
L
K
E
A
A
D
E
----------------------------
L
G
L
--
S
--------------
Y
-
E
E
A
-
I
G
E
A
A
F
--
Y
G
P
K
-----
L
D
V
Q
V
K
T
-----------------------
A
M
-
G
K
E
E
T
------------------
L
S
-------------
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
I
G
Q
-
D
G
-
E
H
-
H
-
R
P
--
V
V
I
H
R
--
G
V
V
S
--
T
M
E
R
-
F
V
A
F
L
T
E
E
T
-----------------
K
--
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
--
V
---
N
V
D
------------
L
H
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
G
V
-
R
V
S
I
D
D
R
-
N
-
E
K
-
M
G
Y
K
I
R
E
A
Q
-
M
Q
K
I
-
P
Y
Q
I
V
V
G
D
K
E
V
E
---------
N
N
Q
V
N
V
R
Q
Y
G
S
Q
D
--
Q
----
E
T
V
E
K
D
E
F
I
W
N
L
V
D
E
I
R
L
K
-----------------------------------------------------------------------------------------
65
Fugue
65.00
23%
-54
- C1 -
1HC7
1
SYP_THET8
A:
[5-477]
--------
K
G
L
T
P
Q
S
Q
D
F
S
E
W
Y
L
-
E
V
I
Q
-
K
A
-
E
L
A
D
------------
Y
---
G
------
P
V
R
G
T
I
V
V
R
P
Y
G
Y
A
I
W
E
N
I
Q
Q
V
L
D
R
M
F
-
K
E
--
T
G
H
Q
N
A
Y
F
P
L
F
I
P
M
S
F
L
FS
P
-
E
-
L
A
V
V
T
H
A
G
G
------
E
-
E
---------------------------------------------------------------------------------
L
----
E
E
P
L
A
V
R
P
T
S
E
T
V
I
G
Y
M
W
S
K
W
---
I
R
-
S
W
R
D
---
L
P
Q
L
L
N
Q
W
G
N
V
V
R
W
E
M
R
T
-
R
--
P
F
L
R
T
S
E
F
L
-
W
Q
E
G
H
T
A
H
A
T
R
E
E
A
E
-----------------------------------------
E
E
V
R
---
R
M
L
S
I
Y
A
R
L
A
R
-
E
-
Y
--------
A
-----------------------------------------------
A
I
P
V
I
E
G
------
L
-
K
T
E
K
E
-----------
K
F
A
G
A
V
Y
T
T
T
I
E
A
L
----------------------------------------------------------------------------------------------------------------------------------------------------
M
K
D
G
K
A
L
Q
A
G
T
S
H
Y
L
G
E
N
F
A
R
A
F
D
I
K
F
Q
D
R
-
D
L
-
Q
V
-
K
-
Y
V
--
H
T
--
T
--
S
W
G
L
--
S
-
W
R
-
F
I
G
A
I
I
M
T
H
-
G
----
D
D
--
R
------
G
--
L
V
L
P
P
R
L
A
P
I
Q
V
V
I
V
P
I
Y
K
---
D
E
S
R
---
E
-------
R
V
L
E
A
A
Q
G
L
R
Q
A
L
L
A
--------------
Q
G
L
-
R
V
H
L
D
D
R
-
D
-
Q
H
T
P
G
Y
K
F
H
E
W
E
-
L
K
G
V
-
P
F
R
V
E
L
G
P
K
D
L
E
---------
G
G
Q
A
V
L
A
S
R
L
G
-
G
--
K
----
E
T
L
P
L
A
A
L
P
E
A
L
P
G
K
L
D
A
F
H
E
E
L
Y
R
R
A
L
A
F
R
E
D
H
T
R
K
V
DT
Y
E
A
F
K
E
A
V
Q
E
G
F
A
L
A
F
H
CGD
K
A
C
E
R
L
I
Q
E
E
TTATTRCVPFEAE
P
E
E
G
F
CVRCGRPSAYG
K
R
V
V
F
A
KAY
52
HHSearch
64.00
20%
-64
- C1 -
1EVL
2
SYT_ECOLI
A:
[1-393]
--------------------
R
D
H
-
R
K
I
G
-
K
Q
L
D
L
Y
H
------------
M
Q
E-
E
------
A
-
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
--
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
--
E
-
K
-
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
S
S
-----------------------------------------------------------------------------------
E
----
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
---
L
K
-
S
Y
R
D
---
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
-
G
L
M
R
V
R
G
F
T
-
Q
D
D
A
H
I
F
C
T
E
E
-
Q
I
R
-----------------------------------------
D
E
V
N
---
G
C
I
R
L
V
Y
D
M
Y
S
-
T
-
F
--------
G
-
F
E
---
K
I
V
V
K
L
S
T
R
P
E
K
R
--------------
I
G
S
D
-----------
E
M
W
D
-----------------------
R
----------
A
E
A
D
L
A
V
A
L
E
------------
E
----------------------------
N
N
I
--
P
---------
F
---
E
Y
---
Q
-
L
G
E
G
A
F
--
Y
G
P
K
-----
I
E
F
T
L
-------------------
Y
D
C
----
L
-
D
R
A
W
Q
------------------
C
------------
G
-
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
-
D
N
-
E
R
-
K
-
V
P
--
V
M
--
I
--
H
R
A
I
LG
S
M
E
R
-
F
I
G
I
L
T
E
E
F
-----------------
A
--
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
--
I
---
T
D
-------------
S
Q
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
-
R
V
K
A
D
L
R
-
N
-
E
K
-
I
G
F
K
I
R
E
H
T
-
L
R
R
V
-
P
Y
M
L
V
C
G
D
K
E
V
E
---------
S
G
K
V
A
V
R
T
R
R
G
K
D
--
L
----
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
-----------------------------------------------------------------------------------------
55
HHSearch
62.65
17%
-55
- C1 -
2ZT5
1
SYG_HUMAN
A:
[89-658]
----------------------------------------------------
G
------
V
-
S
G
L
Y
D
F
G
P
V
G
C
A
L
K
N
N
I
I
Q
T
W
R
Q
H
F
-
I
Q
E-
E
Q
I
L
E
I
D
C
T
M
L
T
P
E
P
V
L
--
K
-
T
-
S
G
H
V
D
K
F
A
D
F
M
V
K
D
V
K
-
N
GECFR
A
D
H
L
L
K
A
H
L
Q
K
L
M
S
DKKCS
V
E
K
K
S
E
M
E
S
V
L
A
Q
LDNYG
Q
Q
E
L
A
D
L
F
V
N
Y
NVKSPITGNDLS
P
P
V
S
F
N
L
M
F
K
T
F
I
G
PG
G
----
N
M
P
G
Y
L
R
P
E
T
A
Q
G
I
F
L
N
F
K
R
L
---
L
E
F
N
Q
G
K
---
L
P
F
A
A
A
Q
I
G
N
S
F
R
N
E
I
S
P
-
R
S
-
G
L
I
R
V
R
E
F
T
-
M
A
E
I
E
H
F
V
D
P
S
E
K
D
H
PKFQNVAD
L
H
L
Y
L
Y
S
A
K
A
Q
V
S
G
Q
S
A
R
KMR
L
G
D
A
V
E
Q
GVINN
T
V
L
G
---
Y
F
I
G
R
I
Y
L
Y
L
T
-
K
-
V
--------
G
-
I
S
PDK
L
-
R
F
R
Q
H
M
E
N
E
M
A
H
Y
A
C
D
C
W
D
A
E
S
K
T
S
Y
G
W
I
E
I
V
G
C
A
D
R
-------------------------------------------------------------------------------
S
C
Y
D
L
S
C
H
A
--
R
A
T
K
V
--
P
-
L
V
--
A
E
K
P
-----------------------------------------------------------------------------------------------------------------------
Y
V
E
E
V
-
V
-
P
N
--
V
I
-----
E
P
S
F
--
G
L
G
R
-
I
M
Y
T
V
F
E
H
T
F
H
V
R
EG
D
E
Q
R
T
------
F
--
F
S
F
P
A
V
V
A
P
F
K
C
S
V
L
P
--
L
---
S
Q
N
Q
-----------
E
F
M
P
F
V
K
E
L
S
E
A
L
T
R
--------------
H
G
V
-
S
H
K
V
D
D
S
-
S
-
G
S
-
I
G
R
R
Y
A
R
T
D
-
E
I
G
V
-
A
F
G
V
T
I
D
F
D
T
V
N
KT-------
P
H
T
A
T
L
R
D
R
D
S
M
R
--
Q
----
I
R
A
E
I
S
E
L
P
S
I
V
Q
D
L
A
N
G
N
-----------------------------------------------------------------------------------------
48
HHSearch
62.58
19%
-64
- C1 -
1QF6
2
SYT_ECOLI
A:
[238-633]
----------------
E
A
A
K
R
D
H
-
R
K
I
G
-
K
Q
L
D
L
Y
H
------------
M
Q
E-
E
------
A
-
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
--
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
--
E
-
K
-
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
S
S
-----------------------------------------------------------------------------------
E
----
N
R
E
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
---
L
K
-
S
Y
R
D
---
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
-
G
L
M
R
V
R
G
F
T
-
Q
D
D
A
H
I
F
C
T
E
E
-
Q
I
R
-----------------------------------------
D
E
V
N
---
G
C
I
R
L
V
Y
D
M
Y
S
-
T
-
F
--------
G
-
F
E
K
--
I
-
V
V
K
L
S
T
R
P
E
K
-------------------------
R
I
G
S
D
E
M
W
D
R
A
------
E
---------------------------------------
A
D
L
A
V
A
L
E
E
----------------------------
N
N
I
--
P
---------
F
------
E
Y
Q
-
L
G
E
G
A
F
--
Y
G
P
K
-----
I
E
F
T
L
Y
D
C
---
L
D
R
A
W
Q
C
G
T
V
Q
----------------------------------------
L
--------
D
F
S
L
----
P
S
R
L
S
A
S
Y
V
G
E
-
D
N
-
E
R
-
K
-
V
P
--
V
M
--
I
H
R
A
I
L
G
--
S
M
E
R
-
F
I
G
I
L
T
E
E
F
-
A
------------------
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
--
I
---
T
D
S
-------------
Q
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
-
R
V
K
A
D
L
R
-
N
-
E
K
-
I
G
F
K
I
R
E
H
T
-
L
R
R
V
-
P
Y
M
L
V
C
G
D
K
E
V
E
---------
S
G
K
V
A
V
R
T
R
R
G
K
D
--
L
----
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
-----------------------------------------------------------------------------------------
51
HHSearch
61.72
16%
-56
- C1 -
3A32
6
SYT1_AERPE
A:
[7-443]
--------------------
K
T
H
-
I
D
Y
A
-
Y
E
L
D
I
T
V
KPDSRVPVFNRE
F
A
T
F
T
------
G
-
A
G
V
P
L
F
S
L
G
G
G
P
I
R
Y
A
L
A
E
V
L
A
K
F
H
-
A
R
--
R
G
Y
Y
V
V
E
T
P
I
I
A
S
T
E
L
F
--
K
-
V
-
S
G
H
I
E
F
Y
R
N
N
M
Y
L
F
D
I
-----------------------------------------------------------------------------------
E
----
G
H
E
F
A
V
K
P
M
N
C
P
Y
H
I
L
L
F
L
N
E
V
A
K
H
R
-
S
K
L
P
---
L
P
F
K
V
F
E
F
G
R
V
H
R
Y
E
P
S
G
S
I
Y
-
G
L
L
R
V
R
G
F
T
-
Q
D
D
A
H
I
I
V
P
G
G
R
-
V
I
-----------------------------------------
D
V
V
Y
D
V
F
E
E
M
K
L
V
L
E
R
L
F
-
K
-
L
--------
G
-
V
S
SET
F
-
K
V
R
L
S
M
S
D
K
S
L
I
---------------
G
K
E
F
M
G
S
K
-
E
E
W
----
E
G
A
------
E
-
E
A
--------------------------------------
L
R
E
A
A
S
R
I
-----
N
E
----------
K
Y
G
--------------
I
-----------
D
I
-
V
E
L
-
E
G
E
A
A
F
--
Y
G
P
K
-----
L
D
F
I
M
M
V
E
--------------
E
-----
S
-
G
V
-
S
K
E
W
Q
------------------
M
-
G
T
I
Q
F
--------
D
F
N
L
P
----
R
R
F
R
L
Y
D
V
V
R
E
E
F
G
I
E
-
E
-
V
Y
--
I
I
--
H
R
-
A
L
L
G
--
S
I
E
R
-
F
L
G
V
Y
L
E
H
R
-
R
----
G
--------------
R
M
P
F
T
L
A
P
I
Q
F
A
V
I
A
--
V
---
K
T
G
G
EV
D
R
-------
E
I
E
D
L
A
S
S
I
A
K
G
L
L
D
--------------
K
G
F
-
R
V
A
V
K
G
S
-
S
K
T
G
-
L
S
S
D
V
R
H
I
E
S
T
A
K
P
-
A
V
N
V
F
I
G
A
K
E
V
R
---------
E
K
V
L
D
V
R
V
F
D
L
E
S
--
M
K
R
R
R
L
A
I
A
Y
G
D
A
A
D
A
V
E
N
L
A
A
V
A
-----------------------------------------------------------------------------------------
70
Fugue
59.52
15%
-50
- C1 -
3A32
6
SYT1_AERPE
A:
[7-471]
----
K
T
H
I
D
Y
A
Y
E
L
D
I
T
V
K
P
D
S
R
-
V
P
V
F
-
N
R
-
E
F
A
T
------------
F
---
T
------
G
-
A
G
V
P
L
F
S
L
G
G
G
P
I
R
Y
A
L
A
E
V
L
A
K
F
H
-
A
R
--
R
G
Y
Y
V
V
E
T
P
I
I
A
S
T
E
L
F
--
K
-
V
-
S
G
H
I
E
F
Y
R
N
N
M
Y
L
F
D
I
-----------------------------------------------------------------------------------
E
----
G
H
E
F
A
V
K
P
M
N
C
P
Y
H
I
L
L
F
L
N
E
---
V
A
-
K
H
R
S
KLP
L
P
F
K
V
F
E
F
G
R
V
H
R
Y
E
P
S
G
-
S
I
Y
G
L
L
R
V
R
G
F
T
-
Q
D
D
A
H
I
I
V
P
-
G
G
R
V
I
-----------------------------------------
D
V
V
Y
---
D
V
F
E
E
M
K
L
V
L
E
-
R
-
L
FKLGVSSE
T
-
F
K
---
V
-
R
L
S
M
S
D
K
S
L
I
G
K
E
F
M
G
S
K
E
--
E
W
E
G
A
E
E
A
L
R
E
A
A
S
R
I
N
E
K
Y
G
I
D
I
V
------
E
-
L
E
G
E
-----------
A
A
F
Y
G
P
---------------------------------
K
L
D
F
I
M
M
V
E
E
S
G
V
S
K
E
W
Q
M
G
T
I
Q
F
D
F
N
L
P
R
R
F
R
L
Y
D
V
V
R
E
E
F
-
G
I
E
-
E
V
Y
I
I
H
--
R
A
L
L
G
------------------------------------------------------------------------------------------------------------------------
S
I
E
R
-
F
L
G
V
Y
L
E
H
R
-
R
----
G
R
--
M
------
P
--
F
T
L
----
A
P
I
Q
F
A
V
I
A
--
V
KTG
G
E
V
D
---
R
-------
E
I
E
D
L
A
S
S
I
A
K
G
L
L
D
--------------
K
G
F
-
R
V
A
V
K
G
S
-
S
-
K
T
G
L
S
S
D
V
R
H
I
E
-
S
T
A
K
P
A
V
N
V
F
I
G
A
K
E
V
R
---------
E
K
V
L
D
V
R
V
F
D
L
E
S
--
M
----
K
R
R
R
L
A
I
A
Y
G
D
A
A
D
A
V
E
N
L
A
A
V
A
E
E
L
E
S
P
V
R
S
L
SGQA
P
R
I
P
A
DFSFML------------------------------------------------------------
54
HHSearch
59.21
17%
-44
- C1 -
1ATI
-
SYG_THET8
A:
[6-503]
--------------------
D
E
L
V
A
L
C
K
-
R
R
-
G
F
I
F
------------
Q
---
S
SEIYGG
L
-
Q
G
V
Y
D
Y
G
P
L
G
V
E
L
K
N
N
L
K
Q
A
W
W
R
R
N
-
V
Y
ER
D
D
M
E
G
L
D
A
S
V
L
T
H
R
L
V
L
--
H
-
Y
-
S
G
H
E
A
T
F
A
D
P
M
V
D
N
----WTP
P
R
Y
F
NM
M
F
Q
D
L
R
G
PRGG-------------------------------------------------------------
R
----
G
L
L
A
Y
L
R
P
E
T
A
Q
G
I
F
V
N
F
K
N
V
L
--
D
A
-
T
S
R
K
---
L
G
F
G
I
A
Q
I
G
K
A
F
R
N
E
I
T
P
-
R
N
-
F
I
F
R
V
R
E
F
E
-
Q
M
E
I
E
Y
F
V
R
P
G
-
E
D
E
-----------------------------------------
Y
W
H
R
---
Y
W
V
E
E
R
L
K
W
W
Q
-
E
-
M
--------
G
-
L
S
REN
L
-
V
P
Y
Q
Q
P
P
E
S
S
----
A
H
------
Y
A
K
A
T
V
D
I
L
Y
R
F
P
H
--------------------------------------------------------------------------------
G
S
------------------------------------------------------
L
E
L
E
--------
G
I
A
-----
Q
R
T
------------
D
F
--------------
D
L
G
S
H
--
T
K
D
Q
E
A
L
G
I
T
A
R
---
V
L
R
N
E
H
S
T
-
Q
R
L
A
Y
R
D
P
-
E
T
-
G
K
-
W
F
V
P
--
Y
V
--
I
--
E
P
S
A
--
G
V
D
R
G
V
L
A
L
L
A
E
A
F
-
T
----
R
E
--
E
L
PNG
E
E
R
I
V
L
K
L
K
P
Q
L
A
P
I
K
V
A
V
I
P
--
L
---
V
K
N
R
---
P
-------
E
I
T
E
Y
A
K
R
L
K
A
R
L
L
A
--------------
L
G
L
G
R
V
L
Y
E
D
T
---
G
N
-
I
G
K
A
Y
R
R
H
D
-
E
V
G
T
-
P
F
A
V
T
V
D
Y
D
T
I
G
QSKDGTTRL
K
D
T
V
T
V
R
D
R
D
T
M
E
--
Q
----
I
R
L
H
V
D
E
L
E
G
F
L
R
E
R
L
R
W
------------------------------------------------------------------------------------------