@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0764: (2015-12-18 )
MIDCAIIGGGPAGLSAGLYATRGGVKNAVLFEKGMPGGQITGSSEIENYPGVKEVVSGLDFMQPWQEQCFRFGLKHEMTAIQRVSKKGSHFVILAEDGKTFEAKSVIIATGGSPKRTGIKGESEYWGKGVSTCATCDGFFYKNKEVAVLGGGDTAVEEAIYLANICKKVYLIHRRDGFRCAPITLEHAKNNSKIEFLTPYVVEEIKGDASGVSSLSIKNTATNEKRELVVPGLFIFVGYDVNNAVLKQEDNSMLCECDEYGSIVVDFSMKTNVQGLFAAGDIRIFAPKQVVCAASDGATAALSVISYLEHH
Atome Classification :
(24 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20.....-...30.....-----..-----.40........50........60........70......----..80.....-..-.----90--.........100.......110.......120.......130.......--140.......150.......160.......170.......180.......190.......200..--.....210.......220.......230.......240.......250.......260....-...270.......280.--...--...290.......300.......310--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
I
D
C
A
I
IGG
G
P
A
G
L
SA
G
L
YATRGGVK-
N
A
V
L
FEKGMP-----GG-----QITGSSEIENYP
G
V
K
E
V
V
SGL
D
F
M
Q
P
W
Q
E
Q
C
F
RFGL
K
H
E
----
M
T
A
I
Q
R
V
SK-KG-
S
----
H
---
F
V
I
L
AEDGKT
F
E
A
K
S
V
I
I
ATGGSPKRTGIKGE
S
E
Y
WGKGV
S
T
CATCD
G
F
--
F
Y
KN
K
E
V
A
V
LGGG
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
HRRDG
F
R
CA
P
I
T
L
E
HAKNNS
K
I
E
F
L
T
P
Y
V
V
E
E
--IKGDASGV
S
S
L
S
IKNTATNEK
R
E
L
V
V
P
G
L
F
I
F
V
G
YDVN
N
A
VLKQEDN
S
M
L
C
ECDEY
G
S
I
V
V
D
-
F
SMKTNV
Q
G
L
F
AAG
D
I
R
--
I
FA--P
K
Q
V
V
C
AASD
G
A
T
A
A
L
S
V
I
S
Y
L
EHH---
23
PsiBlast_CBE
99.31
98%
-133
- C3 -
2Q0L
2
TRXB_HELPY
B:
[1-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
-
N
A
V
L
F
E
K
G
M
P
-----
G
G
-----
Q
I
T
G
S
S
E
I
E
N
Y
P
G
V
K
E
V
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
G
L
K
H
E
----
M
T
A
V
Q
R
V
S
K
-
K
D
-
S
----
H
---
F
V
I
L
A
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
S
P
K
R
T
G
I
K
G
E
S
E
Y
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
I
T
L
E
H
A
K
N
N
D
K
I
E
F
L
T
P
Y
V
V
E
E
--
I
K
G
D
A
S
G
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
L
V
V
P
G
F
F
I
F
V
G
Y
D
V
N
N
A
V
L
K
Q
E
D
N
S
M
L
C
K
C
D
E
Y
G
S
I
V
V
D
-
F
S
M
K
T
N
V
Q
G
L
F
A
A
G
D
I
R
--
I
F
A
--
P
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
V
I
S
Y
L
E
H
H
---
68
HHSearch
98.72
98%
-131
- C3 -
2Q0L
2
TRXB_HELPY
A:
[1-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
-
N
A
V
L
F
E
K
G
M
P
-----
G
G
-----
Q
I
T
G
S
S
E
I
E
N
Y
P
G
V
K
E
V
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
G
L
K
H
E
----
M
T
A
V
Q
R
V
S
K
-
K
D
-
S
----
H
---
F
V
I
L
A
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
S
P
K
R
T
G
I
K
G
E
S
E
Y
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
I
T
L
E
H
A
K
N
N
D
K
I
E
F
L
T
P
Y
V
V
E
E
--
I
K
G
D
A
S
G
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
L
V
V
P
G
F
F
I
F
V
G
Y
D
V
N
N
A
V
L
K
Q
E
D
N
S
M
L
C
K
C
D
E
Y
G
S
I
V
V
D
-
F
S
M
K
T
N
V
Q
G
L
F
A
A
G
D
I
R
--
I
F
A
--
P
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
V
I
S
Y
L
E
H
H
---
2
PsiBlast_PDB
98.72
98%
-131
- C3 -
2Q0L
2
TRXB_HELPY
A:
[1-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
-
N
A
V
L
F
E
K
G
M
P
-----
G
G
-----
Q
I
T
G
S
S
E
I
E
N
Y
P
G
V
K
E
V
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
G
L
K
H
E
----
M
T
A
V
Q
R
V
S
K
-
K
D
-
S
----
H
---
F
V
I
L
A
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
S
P
K
R
T
G
I
K
G
E
S
E
Y
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
I
T
L
E
H
A
K
N
N
D
K
I
E
F
L
T
P
Y
V
V
E
E
--
I
K
G
D
A
S
G
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
L
V
V
P
G
F
F
I
F
V
G
Y
D
V
N
N
A
V
L
K
Q
E
D
N
S
M
L
C
K
C
D
E
Y
G
S
I
V
V
D
-
F
S
M
K
T
N
V
Q
G
L
F
A
A
G
D
I
R
--
I
F
A
--
P
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
V
I
S
Y
L
E
H
H
---
1
PsiBlast_PDB
98.66
98%
-134
- C3 -
2Q0K
3
TRXB_HELPY
A:
[1-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
-
N
A
V
L
F
E
K
G
M
P
-----
G
G
-----
Q
I
T
G
S
S
E
I
E
N
Y
P
G
V
K
E
V
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
G
L
K
H
E
----
M
T
A
V
Q
R
V
S
K
-
K
D
-
S
----
H
---
F
V
I
L
A
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
S
P
K
R
T
G
I
K
G
E
S
E
Y
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
I
T
L
E
H
A
K
N
N
D
K
I
E
F
L
T
P
Y
V
V
E
E
--
I
K
G
D
A
S
G
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
L
V
V
P
G
F
F
I
F
V
G
Y
D
V
N
N
A
V
L
K
Q
E
D
N
S
M
L
C
K
C
D
E
Y
G
S
I
V
V
D
-
F
S
M
K
T
N
V
Q
G
L
F
A
A
G
D
I
R
--
I
F
A
--
P
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
V
I
S
Y
L
E
H
----
3
PsiBlast_PDB
98.26
98%
-131
- C3 -
3ISH
2
TRXB_HELPY
A:
[1-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
-
N
A
V
L
F
E
K
G
M
P
-----
G
G
-----
Q
I
T
G
S
S
E
I
E
N
Y
P
G
V
K
E
V
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
G
L
K
H
E
----
M
T
A
V
Q
R
V
S
K
-
K
D
-
S
----
H
---
F
V
I
L
A
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
S
P
K
R
T
G
I
K
G
E
S
E
Y
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
I
T
L
E
H
A
K
N
N
D
K
I
E
F
L
T
P
Y
V
V
E
E
--
I
K
G
D
A
S
G
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
L
V
V
P
G
F
F
I
F
V
G
Y
D
V
N
N
A
V
L
K
Q
E
D
N
S
M
L
C
K
C
D
E
Y
G
S
I
V
V
D
-
F
S
M
K
T
N
V
Q
G
L
F
A
A
G
D
I
R
--
I
F
A
--
P
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
V
I
S
Y
L
E
H
H
---
24
PsiBlast_CBE
97.60
98%
-130
- C3 -
2Q0K
3
TRXB_HELPY
B:
[1-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
-
N
A
V
L
F
E
K
G
M
P
-----
G
G
-----
Q
I
T
G
S
S
E
I
E
N
Y
P
G
V
K
E
V
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
G
L
K
H
E
----
M
T
A
V
Q
R
V
S
K
-
K
D
-
S
----
H
---
F
V
I
L
A
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
S
P
K
R
T
G
I
K
G
E
S
E
Y
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
I
T
L
E
H
A
K
N
N
D
K
I
E
F
L
T
P
Y
V
V
E
E
--
I
K
G
D
A
S
G
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
L
V
V
P
G
F
F
I
F
V
G
Y
D
V
N
N
A
V
L
K
Q
E
D
N
S
M
L
C
K
C
D
E
Y
G
S
I
V
V
D
-
F
S
M
K
T
N
V
Q
G
L
F
A
A
G
D
I
R
--
I
F
A
--
P
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
V
I
S
Y
L
E
H
----
22
PsiBlast_CBE
97.34
98%
-129
- C3 -
3ISH
2
TRXB_HELPY
B:
[1-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
-
N
A
V
L
F
E
K
G
M
P
-----
G
G
-----
Q
I
T
G
S
S
E
I
E
N
Y
P
G
V
K
E
V
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
G
L
K
H
E
----
M
T
A
V
Q
R
V
S
K
-
K
D
-
S
----
H
---
F
V
I
L
A
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
S
P
K
R
T
G
I
K
G
E
S
E
Y
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
I
T
L
E
H
A
K
N
N
D
K
I
E
F
L
T
P
Y
V
V
E
E
--
I
K
G
D
A
S
G
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
L
V
V
P
G
F
F
I
F
V
G
Y
D
V
N
N
A
V
L
K
Q
E
D
N
S
M
L
C
K
C
D
E
Y
G
S
I
V
V
D
-
F
S
M
K
T
N
V
Q
G
L
F
A
A
G
D
I
R
--
I
F
A
--
P
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
V
I
S
Y
L
E
H
H
---
21
PsiBlast_CBE
96.86
98%
-128
- C3 -
3ISH
1
TRXB_HELPY
C:
[1-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
-
N
A
V
L
F
E
K
G
M
P
-----
G
G
-----
Q
I
T
G
S
S
E
I
E
N
Y
P
G
V
K
E
V
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
G
L
K
H
E
----
M
T
A
V
Q
R
V
S
K
-
K
D
-
S
----
H
---
F
V
I
L
A
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
S
P
K
R
T
G
I
K
G
E
S
E
Y
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
I
T
L
E
H
A
K
N
N
D
K
I
E
F
L
T
P
Y
V
V
E
E
--
I
K
G
D
A
S
G
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
L
V
V
P
G
F
F
I
F
V
G
Y
D
V
N
N
A
V
L
K
Q
E
D
N
S
M
L
C
K
C
D
E
Y
G
S
I
V
V
D
-
F
S
M
K
T
N
V
Q
G
L
F
A
A
G
D
I
R
--
I
F
A
--
P
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
V
I
S
Y
L
E
H
H
---
69
HHSearch
80.75
64%
-121
- C3 -
3R9U
2
?
A:
[4-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
D
V
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
L
K
N
V
-
V
M
F
E
K
G
M
P
-----
G
G
-----
Q
I
T
S
S
S
E
I
E
N
Y
P
G
V
A
Q
V
M
D
G
I
S
F
M
A
P
W
S
E
Q
C
M
R
F
G
L
K
H
E
----
M
V
G
V
E
Q
I
L
K
N
S
D
-
G
----
S
---
F
T
I
K
L
E
G
G
K
T
E
L
A
K
A
V
I
V
C
T
G
S
A
P
K
K
A
G
F
K
G
E
D
E
F
F
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
L
E
E
A
L
Y
L
A
N
I
C
S
K
I
Y
L
I
H
R
R
D
E
F
R
A
A
P
S
T
V
E
K
V
K
K
N
E
K
I
E
L
I
T
S
A
S
V
D
E
--
V
Y
G
D
K
M
G
V
A
G
V
K
V
K
-
L
K
D
G
S
I
R
D
L
N
V
P
G
I
F
T
F
V
G
L
N
V
R
N
E
I
L
K
Q
D
D
S
K
F
L
C
N
M
E
E
G
G
Q
V
S
V
D
-
L
K
M
Q
T
S
V
A
G
L
F
A
A
G
D
L
R
--
K
D
A
--
P
K
Q
V
I
C
A
A
G
D
G
A
V
A
A
L
S
A
M
A
Y
I
E
S
L
---
4
PsiBlast_PDB
79.44
62%
-122
- C3 -
3R9U
2
?
A:
[5-312]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
V
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
L
K
-
N
V
V
M
F
E
K
G
M
P
-----
G
G
-----
Q
I
T
S
S
S
E
I
E
N
Y
P
G
V
A
Q
V
M
D
G
I
S
F
M
A
P
W
S
E
Q
C
M
R
F
G
L
K
H
E
----
M
V
G
V
E
Q
I
L
K
-
N
S
-
D
G---
S
---
F
T
I
K
L
E
G
G
K
T
E
L
A
K
A
V
I
V
C
T
G
S
A
P
K
K
A
G
F
K
G
E
D
E
F
F
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
L
E
E
A
L
Y
L
A
N
I
C
S
K
I
Y
L
I
H
R
R
D
E
F
R
A
A
P
S
T
V
E
K
V
K
K
N
E
K
I
E
L
I
T
S
A
S
V
D
E
--
V
Y
G
D
K
M
G
V
A
G
V
K
V
K
-
L
K
D
G
S
I
R
D
L
N
V
P
G
I
F
T
F
V
G
L
N
V
R
N
E
I
L
K
Q
D
D
S
K
F
L
C
N
M
E
E
G
G
Q
V
S
V
D
-
L
K
M
Q
T
S
V
A
G
L
F
A
A
G
D
L
R
--
K
D
A
--
P
K
Q
V
I
C
A
A
G
D
G
A
V
A
A
L
S
A
M
A
Y
I
E
S
L
---
73
HHSearch
67.87
42%
-107
- C3 -
2Q7V
2
?
A:
[8-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
D
V
V
I
I
G
G
G
P
A
G
L
T
A
A
I
Y
T
G
R
A
Q
L
S
-
T
-
L
I
L
E
K
G
M
P
-----
G
G
-----
Q
I
A
W
S
E
E
V
E
N
F
P
G
F
P
E
P
I
A
G
M
E
L
A
Q
R
M
H
Q
Q
A
E
K
F
G
A
K
V
E
----
M
D
E
V
Q
G
V
Q
H
-
D
A
-
T
SHPY
P
---
F
T
V
R
G
Y
-
N
G
E
Y
R
A
K
A
V
I
L
A
T
G
A
D
P
R
K
L
G
I
P
G
E
D
N
F
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
G
K
K
V
V
V
I
G
G
G
D
A
A
V
E
E
G
M
F
L
T
K
F
A
D
E
V
T
V
I
H
R
R
D
T
L
R
A
N
K
V
A
Q
A
R
A
F
A
N
P
K
M
K
F
I
W
D
T
A
V
E
E
--
I
Q
G
A
D
-
S
V
S
G
V
K
L
R
N
L
K
T
G
E
V
S
E
L
A
T
D
G
V
F
I
F
I
G
H
V
P
N
T
A
F
V
K
D
T
-----
V
S
L
R
D
D
G
Y
V
D
V
R
-
D
E
I
Y
T
N
I
P
M
L
F
A
A
G
D
V
S
--
D
Y
I
--
Y
R
Q
L
A
T
S
V
G
A
G
T
R
A
A
M
M
T
E
R
Q
L
A
A
L
---
70
HHSearch
66.76
36%
-109
- C3 -
3F8D
3
?
A:
[15-319]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
-
T
-
L
V
I
G
E
-
T
P
-----
G
G
-----
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
-
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
----
L
D
I
V
E
K
I
E
N
-
R
-------
E
---
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
--
I
K
G
D
K
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
----
I
E
T
D
T
N
G
Y
I
K
V
D
-
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
--
S
A
W
LG
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
K
---
40
PsiBlast_CBE
66.28
37%
-117
- C3 -
3F8D
3
?
D:
[17-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
-
T
L
V
I
G
E
--
T
P
-----
G
G
-----
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
-
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
----
L
D
I
V
E
K
I
E
N
-
R
G
-
D
----
E
---
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
--
I
K
G
D
K
V
-
V
K
Q
V
V
V
E
N
L
K
--------
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
----
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
-
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
SA
W
L
G
--
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
----
5
PsiBlast_PDB
65.86
43%
-107
- C3 -
2Q7V
2
?
A:
[10-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
V
I
I
G
G
G
P
A
G
L
T
A
A
I
Y
T
G
R
A
Q
L
S
-
T
L
I
L
-
E
K
G
M
P
-----
G
G
-----
Q
I
A
W
S
E
E
V
E
N
F
P
G
F
P
E
P
I
A
G
M
E
L
A
Q
R
M
H
Q
Q
A
E
K
F
G
A
K
V
E
----
M
D
E
V
Q
G
V
Q
H
-
D
A
T
S
----
H
PYP
F
T
V
R
G
Y
N
G
E
-
Y
R
A
K
A
V
I
L
A
T
G
A
D
P
R
K
L
G
I
P
G
E
D
N
F
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
G
K
K
V
V
V
I
G
G
G
D
A
A
V
E
E
G
M
F
L
T
K
F
A
D
E
V
T
V
I
H
R
R
D
T
L
R
A
N
K
V
A
Q
A
R
A
F
A
N
P
K
M
K
F
I
W
D
T
A
V
E
E
--
I
Q
G
-
A
D
S
V
S
G
V
K
L
R
N
L
K
T
G
E
V
S
E
L
A
T
D
G
V
F
I
F
I
G
H
V
P
N
T
A
F
V
K
D
-----
T
V
S
L
R
D
D
G
Y
V
D
V
R
-
D
E
I
Y
T
N
I
P
M
L
F
A
A
G
D
V
S
--
D
Y
I
--
Y
R
Q
L
A
T
S
V
G
A
G
T
R
A
A
M
M
T
E
R
Q
L
A
A
L
---
6
PsiBlast_PDB
65.74
37%
-104
- C3 -
2A87
5
TRXB_MYCTU
A:
[16-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
L
Y
A
A
R
A
Q
L
A
--
P
L
V
F
E
G
T
S
F
-----
G
G
-----
A
L
M
T
T
T
D
V
E
N
Y
P
G
F
R
N
G
I
T
G
P
E
L
M
D
E
M
R
E
Q
A
L
R
F
G
A
D
L
R
----
M
E
D
V
E
S
V
S
L
-
H
G
-
P
----
L
---
K
S
V
V
T
A
D
G
Q
T
H
R
A
R
A
V
I
L
A
M
G
A
A
A
R
Y
L
Q
V
P
G
E
Q
E
L
L
G
R
G
V
S
S
C
A
T
C
D
G
F
--
F
F
R
D
Q
D
I
A
V
I
G
G
G
D
S
A
M
E
E
A
T
F
L
T
R
F
A
R
S
V
T
L
V
H
R
R
D
E
F
R
A
S
K
I
M
L
D
R
A
R
N
N
D
K
I
R
F
L
T
N
H
T
V
V
A
--
V
D
G
D
T
T
-
V
T
G
L
R
V
R
D
T
N
T
G
A
E
T
T
L
P
V
T
G
V
F
V
A
I
G
H
E
P
R
S
G
L
V
R
E
A
-----
I
D
V
D
P
D
G
Y
V
L
V
Q
G
R
T
T
S
T
S
L
P
G
V
F
A
A
G
D
L
V
--
D
R
T
--
Y
R
Q
A
V
T
A
A
G
S
G
C
A
A
A
I
D
A
E
R
W
L
A
E
H
---
36
PsiBlast_CBE
65.52
37%
-110
- C3 -
3F8R
3
?
B:
[17-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
-
T
L
V
I
G
E
--
T
P
-----
G
G
-----
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
-
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
----
L
D
I
V
E
K
I
E
N
-
R
--
D
----
E
---
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
--
I
K
G
D
K
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
----
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
-
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
SA
W
L
G
--
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
K
---
26
PsiBlast_CBE
65.45
37%
-103
- C3 -
2A87
5
TRXB_MYCTU
B:
[16-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
L
Y
A
A
R
A
Q
L
A
--
P
L
V
F
E
G
T
S
F
-----
G
G
-----
A
L
M
T
T
T
D
V
E
N
Y
P
G
F
R
N
G
I
T
G
P
E
L
M
D
E
M
R
E
Q
A
L
R
F
G
A
D
L
R
----
M
E
D
V
E
S
V
S
L
-
H
G
-
P
----
L
---
K
S
V
V
T
A
D
G
Q
T
H
R
A
R
A
V
I
L
A
M
G
A
A
A
R
Y
L
Q
V
P
G
E
Q
E
L
L
G
R
G
V
S
S
C
A
T
C
D
G
F
--
F
F
R
D
Q
D
I
A
V
I
G
G
G
D
S
A
M
E
E
A
T
F
L
T
R
F
A
R
S
V
T
L
V
H
R
R
D
E
F
R
A
S
K
I
M
L
D
R
A
R
N
N
D
K
I
R
F
L
T
N
H
T
V
V
A
--
V
D
G
D
T
T
-
V
T
G
L
R
V
R
D
T
N
T
G
A
E
T
T
L
P
V
T
G
V
F
V
A
I
G
H
E
P
R
S
G
L
V
R
E
A
-----
I
D
V
D
P
D
G
Y
V
L
V
Q
G
R
T
T
S
T
S
L
P
G
V
F
A
A
G
D
L
V
--
D
R
T
--
Y
R
Q
A
V
T
A
A
G
S
G
C
A
A
A
I
D
A
E
R
W
L
A
E
H
---
58
Fugue
64.91
30%
-109
- C3 -
1HYU
4
AHPF_SALTY
A:
[1-521]
MLD
T
N
M
K
T
Q
L
R
A
Y
L
E
KLT
K
P
V
E
L
I
A
T
L
D
DS
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
DK
V
T
F
K
E
D
NTLPVRKP
S
F
L
I
T
N
PGSQ
Q
G
P
R
F
A
G
SPLGHE
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
KEA
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
LSCHN
C
P
D
V
V
Q
A
L
N
L
M
A
V
L
NPR
I
K
H
T
A
I
D
GGTF
Q
N
E
I
T
E
R
NVMGVP
A
V
F
V
NGKEFGQGRMT
L
T
E
I
V
A
K
V
D
TGAEK
R
A
A
E
A
L
N
K
RD
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
-
T
G
L
M
G
E
R
--
F
-----
G
G
-----
Q
V
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
-
E
G
Q
K
L
A
G
A
L
K
A
H
V
S
D
Y
D
V
D
V
I
DSQS
A
S
K
L
V
P
A
A
T
-
E
G
-
G
----
L
---
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
--
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
V
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
--
V
K
G
D
G
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
S
V
A
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
H
W
L
E
G
A
-----
L
E
R
N
R
M
G
E
I
I
I
D
-
A
K
C
E
T
S
V
K
G
V
F
A
A
G
D
C
T
--
T
V
P
--
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
KIA
25
PsiBlast_CBE
64.91
43%
-108
- C3 -
2Q7V
2
?
B:
[10-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
V
I
I
G
G
G
P
A
G
L
T
A
A
I
Y
T
G
R
A
Q
L
S
-
T
L
I
L
-
E
K
G
M
P
-----
G
G
-----
Q
I
A
W
S
E
E
V
E
N
F
P
G
F
P
E
P
I
A
G
M
E
L
A
Q
R
M
H
Q
Q
A
E
K
F
G
A
K
V
E
----
M
D
E
V
Q
G
V
Q
H
-
D
A
T
S
----
H
PYP
F
T
V
R
G
Y
N
G
E
-
Y
R
A
K
A
V
I
L
A
T
G
A
D
P
R
K
L
G
I
P
G
E
D
N
F
W
G
K
G
V
S
T
C
A
T
C
D
G
F
--
F
Y
K
G
K
K
V
V
V
I
G
G
G
D
A
A
V
E
E
G
M
F
L
T
K
F
A
D
E
V
T
V
I
H
R
R
D
T
L
R
A
N
K
V
A
Q
A
R
A
F
A
N
P
K
M
K
F
I
W
D
T
A
V
E
E
--
I
Q
G
-
A
D
S
V
S
G
V
K
L
R
N
L
K
T
G
E
V
S
E
L
A
T
D
G
V
F
I
F
I
G
H
V
P
N
T
A
F
V
K
D
-----
T
V
S
L
R
D
D
G
Y
V
D
V
R
-
D
E
I
Y
T
N
I
P
M
L
F
A
A
G
D
V
S
--
D
Y
I
--
Y
R
Q
L
A
T
S
V
G
A
G
T
R
A
A
M
M
T
E
R
Q
L
A
A
L
---
34
PsiBlast_CBE
64.63
37%
-115
- C3 -
3F8R
3
?
D:
[17-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
-
T
L
V
I
G
E
--
T
P
-----
G
G
-----
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
-
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
----
L
D
I
V
E
K
I
E
N
-
R
G
-
D
----
E
---
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
--
I
K
G
D
K
V
-
V
K
Q
V
V
V
E
N
L
K
--------
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
----
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
-
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
SA
W
L
G
--
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
----
17
PsiBlast_PDB
60.54
35%
-103
- C3 -
4A65
4
?
A:
[6-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
--
P
V
M
Y
E
G
F
M
A
-----
G
G
VAAGG
Q
L
T
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
I
I
----
T
E
T
I
D
H
V
D
F
-
S
T
-
Q
----
P
---
F
K
L
F
T
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
Y
W
Q
N
G
V
S
A
C
A
I
C
D
G
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
M
Q
E
R
V
L
N
H
P
K
I
E
V
I
W
N
S
E
L
V
E
--
L
E
G
D
G
D
L
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
G
Q
-----
V
K
T
A
D
D
G
Y
I
L
T
E
--
G
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
--
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
H
---
54
PsiBlast_CBE
60.34
34%
-102
- C3 -
2WHD
3
?
B:
[35-341]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
A
A
R
A
E
L
K
--
P
V
L
F
E
G
W
M
A
NDIAA
G
G
-----
Q
L
T
T
T
T
D
V
E
N
F
P
G
F
P
T
G
I
M
G
I
D
L
M
D
N
C
R
A
Q
S
V
R
F
G
T
N
I
L
----
S
E
T
V
T
E
V
D
F
-
S
A
-
R
----
P
---
F
R
V
T
S
-
D
S
T
T
V
L
A
D
T
V
V
V
A
T
G
A
V
A
R
R
L
Y
F
S
G
S
D
T
Y
W
N
R
G
I
S
A
C
A
V
C
D
G
A
AP
I
F
R
N
K
P
I
A
V
I
G
G
G
D
S
A
M
E
E
G
N
F
L
T
K
Y
G
S
Q
V
Y
I
I
H
R
R
N
T
F
R
A
S
K
I
M
Q
A
R
A
L
S
N
P
K
I
Q
V
V
W
D
S
E
V
V
E
A
Y
G
G
A
G
G
G
P
L
A
G
V
K
V
K
N
L
V
T
G
E
V
S
D
L
Q
V
S
G
L
F
F
A
I
G
H
E
P
A
T
K
F
L
---
N
G
Q
L
E
L
H
A
D
G
Y
V
A
T
K
P
G
--
S
T
H
T
S
V
E
G
V
F
A
A
G
D
V
Q
--
D
K
K
--
Y
R
Q
A
I
T
A
A
G
S
G
C
M
A
A
L
D
A
E
H
Y
L
Q
E
V
---
16
PsiBlast_PDB
60.03
35%
-102
- C3 -
4A5L
4
?
A:
[6-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
--
P
V
M
Y
E
G
F
M
A
-----
G
G
VAAGG
Q
L
T
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
I
I
----
T
E
T
I
D
H
V
D
F
-
S
T
-
Q
----
P
---
F
K
L
F
T
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
Y
W
Q
N
G
V
S
A
C
A
I
C
D
G
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
M
Q
E
R
V
L
N
H
P
K
I
E
V
I
W
N
S
E
L
V
E
--
L
E
G
D
G
D
L
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
G
Q
-----
V
K
T
A
D
D
G
Y
I
L
T
E
--
G
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
--
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
H
---
55
PsiBlast_CBE
58.62
34%
-100
- C3 -
2WHD
3
?
A:
[35-341]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
A
A
R
A
E
L
K
--
P
V
L
F
E
G
W
M
A
NDIAA
G
G
-----
Q
L
T
T
T
T
D
V
E
N
F
P
G
F
P
T
G
I
M
G
I
D
L
M
D
N
C
R
A
Q
S
V
R
F
G
T
N
I
L
----
S
E
T
V
T
E
V
D
F
-
S
A
-
R
----
P
---
F
R
V
T
S
-
D
S
T
T
V
L
A
D
T
V
V
V
A
T
G
A
V
A
R
R
L
Y
F
S
G
S
D
T
Y
W
N
R
G
I
S
A
C
A
V
C
D
G
A
AP
I
F
R
N
K
P
I
A
V
I
G
G
G
D
S
A
M
E
E
G
N
F
L
T
K
Y
G
S
Q
V
Y
I
I
H
R
R
N
T
F
R
A
S
K
I
M
Q
A
R
A
L
S
N
P
K
I
Q
V
V
W
D
S
E
V
V
E
A
Y
G
G
A
G
G
G
P
L
A
G
V
K
V
K
N
L
V
T
G
E
V
S
D
L
Q
V
S
G
L
F
F
A
I
G
H
E
P
A
T
K
F
L
---
N
G
Q
L
E
L
H
A
D
G
Y
V
A
T
K
P
G
--
S
T
H
T
S
V
E
G
V
F
A
A
G
D
V
Q
--
D
K
K
--
Y
R
Q
A
I
T
A
A
G
S
G
C
M
A
A
L
D
A
E
H
Y
L
Q
E
V
---