@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0031: (2016-03-11 )
MKKITIQEIAKLSGVSVSTVSRVLNNSPSVSAAKRKKIQAIIDEHNYTPSVFARGMVNKQTKNIGVILPDISNPYFISLITQIQKFALDYMFSTILFNTMLAEPDNKNNQHPLTEEDYLKIILEKQVDGLLILGGEIDKEIVPKEYITALNQLNNAIPVVVIGSKIPELNCLFIERNLKKGVTTLVSHLTALGHKNIGFIGGEAGVKITTYRLESFKEAMTSYQHPVNDDWVVLSDYYTADGYAAMTHLLENSTTLPTALVAINDNVAIGAIRAINDAKLSCPEDIAIVSCDQFMNGDYQTPRLTSMDQHNEYLGKMAILQLISAINGQVEPMIINHNPELIIRESCGSKL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160--.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320....-...330.......340.......350
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
I
T
I
Q
E
I
A
K
LSGV
S
V
S
T
V
S
R
V
LNNSPSV
S
A
A
K
R
K
K
I
Q
A
I
I
D
EHNY
T
P
S
V
F
A
R
G
MVNKQTKN
I
G
V
I
LPDISN
P
Y
F
I
S
L
I
T
Q
I
Q
K
F
A
L
D
Y
M
F
S
T
I
L
F
N
T
M
LAEPDNKNNQHPL
T
E
E
D
Y
L
K
I
I
L
E
KQVD
G
L
L
I
LGGEIDKEIV
P
K
E
Y
I
T
A
L
N
Q
LNNAI
P
V
V
V
I--GSKIP
E
L
N
C
L
F
I
E
R
N
L
K
K
G
V
T
T
L
V
S
H
L
T
A
LGHK
N
I
G
F
IGGEA
G
V
K
I
T
T
Y
R
L
E
S
F
K
E
A
M
T
S
YQHPVND
D
W
V
V
L
S
D
YYTAD
G
Y
A
A
M
T
H
L
LENSTTL
P
T
A
L
V
A
INDN
V
A
I
G
A
I
R
A
INDAKLSCPE
D
I
A
I
V
S
C
D
Q
FMNGDYQTPRLT
S
M
D
Q
H
N
E
Y
L
G
K
M
A
I
L
Q
L
I
S
A
I-NGQV
E
P
M
I
INHNP
E
L
I
I
R
E
SCGSKL
26
PsiBlast_CBE
90.78
31%
-119
- C4 -
1JFT
3
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DA
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
13
PsiBlast_PDB
90.16
31%
-116
- C4 -
2PUC
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
20
PsiBlast_PDB
90.14
31%
-119
- C4 -
1QPZ
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
19
PsiBlast_PDB
90.04
31%
-116
- C4 -
1QP4
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
6
PsiBlast_PDB
89.90
31%
-118
- C4 -
1BDH
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
15
PsiBlast_PDB
89.84
31%
-120
- C4 -
1PNR
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
25
PsiBlast_CBE
89.83
31%
-116
- C4 -
1JFS
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DF
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
11
PsiBlast_PDB
89.66
31%
-115
- C4 -
2PUA
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
5
PsiBlast_PDB
89.55
31%
-117
- C4 -
1VPW
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
M
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
24
PsiBlast_CBE
89.53
31%
-118
- C4 -
1JH9
4
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DR
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
12
PsiBlast_PDB
89.40
31%
-118
- C4 -
2PUB
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
17
PsiBlast_PDB
89.30
31%
-117
- C4 -
1WET
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
23
PsiBlast_CBE
89.27
31%
-115
- C4 -
1ZAY
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
8
PsiBlast_PDB
88.84
31%
-115
- C4 -
1QQA
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
18
PsiBlast_PDB
88.82
31%
-116
- C4 -
1QP0
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
9
PsiBlast_PDB
88.76
31%
-115
- C4 -
1QQB
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
14
PsiBlast_PDB
88.68
31%
-117
- C4 -
2PUD
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
27
PsiBlast_CBE
88.64
31%
-115
- C4 -
2PUG
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
Q
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
7
PsiBlast_PDB
88.45
31%
-117
- C4 -
1QP7
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----
29
PsiBlast_CBE
88.38
31%
-117
- C4 -
2PUE
2
PURR_ECOLI
A:
[2-329]
----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
----
N
N
L
E
K
Q
R
A
-----
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
-----
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
DW
G
E
A
K
A
D
F
T
D
A
V
I
D
-
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
Q
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
-
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
-----