@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0121: (2016-03-12 )
MADSKSFTFELNESVLTAQVGRLDEMAMVVEQRFSELKMTIEDVGNADPGSKISESLGGLQSGLGTISSAFGQLGSSSEAITSGFGTAVGSVGGITDAFKNLGSSVQNGTLFSSLATGIGGMSTMLGGVSGGVQGITNLASGFMELKNHLGGLMSSIGGVGGIMGKLTSPMGLVIIGIVALVAAFAYLMTTNESFRNTVMSVVTQVAQLFGQLVASLMPIIMQIVTAVMQIGAALMPMVMQFISFFAQLLAQLMPFINMLISMLMPVIMQIVQVVMSLVSALLPSIMTVIQGIMSVIQFLIPIIMQIATVVVQIVVTIISYISKIMPIVMTIIGVIVSIITTIISYVVIIATTIASVIGKIISFIASVITAVIGIVQPIIAFITNIFTTIVTIIGAAFQMVFTVASKIWNSIMSTISGIIDGIKAVITGISTTVSSVFNGVKRIITGVFDGIKSAWGGLTDFVGNIFDGVSSAIQTVVDNVKGFVNVVIRGINGAIGLINKIPGVEIGKIPQLISGTTNFQGGFARMNEGGRGEMVVLPSGSQVIPHDATMKYARESARGNKSMLYTSQGADLARVENLLERLLQKNPVIKMDDKVVAEVVSRNQANSFDQYNYTMGGAAYS
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10.----......--------.20..--....---..30.....------------------...40.....-...50........60...-.....70........80---........90.-.......100.......--110.......120.......130.......140..-----------------.....150.......160-........170.......180-----.........190---------.......200.......210...---...----------.220.......------230------.......240.......250......-------------.--..260....----------...270.......280..---------------.....290.----------.......300.-...------...--310....---------------...320-.......-----------..330..-------------....-----------------.340......---------.350.--------......360.......--370.......380.......------390.......400.......-----410..---------.....420.......430.....--....--------440.........450.......460..-...-..470----.........480.......490....--...500...--....510.......-520.......530.......540....-...550.......560.......-----570-........580.......590.....---...600.......610.......620-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MADSK
S
F
T
F
ELN----E
S
V
L
T
A
--------
Q
VG
R
L
--
D
E
M
A
---
M
V
V
E
Q
R
F
S
E
------------------
L
K
M
T
I
E
DVGN-ADPG
S
K
I
S
E
S
L
G
G
L
Q
S
G
L
-
G
T
I
S
S
A
F
G
QLGSSS
E
A
I
---
T
S
GF
G
T
A
VGSV-G
G
I
T
D
A
F
K
N
L
G
SSVQN
G
--
T
L
F
S
S
L
A
T
GI
G
G
M
S
T
M
L
G
GVS
G
G
V
Q
G
I
T
N
L
A
S
G
F
M
-----------------
E
L
K
N
H
L
G
G
L
M
S
S
IGG
V
G
--
G
I
M
G
KLTSP
M
G
L
V
I
I
G
I
V
A
-------
L
V
A
A
F
A
Y
L
MTT
N
---------
E
S
F
R
N
T
V
M
S
V
V
T
Q
V
A
Q
L
F
G
Q
L
V
A
---
S
L
M
----------
P
I
I
M
Q
I
V
T
A
V
M
------
Q
I
G
------
A
A
L
M
P
M
V
M
Q
F
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S
F
F
A
Q
L
L
--
A
Q
L
M
P
F
-------------
I
--
N
M
L
I
S
M
L
M
P
----------
V
I
M
Q
I
V
Q
V
V
M
S
L
V
S
A
L
L
P
---------------
S
I
M
T
V
I
-
Q
G
----------
I
M
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Q
F
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I
-
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Q
------
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A
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V
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---------------
T
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---
Y
I
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K
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P
-----------
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V
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T
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-------------
V
I
V
S
-----------------
I
I
T
T
I
I
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Y
V
V
---------
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I
A
T
T
--------
I
A
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K
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--
T
A
V
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P
I
I
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N
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------
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V
T
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A
A
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M
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A
S
K
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W
-----
N
S
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M
S
---------
T
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D
G
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K
A
V
I
T
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I
--
S
T
T
V
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--
S
V
F
N
--------
G
--
V
K
R
I
I
T
G
V
F
D
G
I
K
S
A
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G
L
T
D
F
V
G
-
N
I
F
-
D
G
V
------
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S
A
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N
V
K
G
F
V
N
V
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GIN
G
A
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--
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L
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NKIPGV--EIGKI
P
Q
L
ISGTTN-FQGGFARMNEGGRG
E
M
V
V
LPSGSQVIP-H
D
A
T
M
K
Y
A
R
E
SARGNK
S
M
L
Y
TSQ-----GA--
D
L
A
R
V
E
N
L
L
E
R
L
L
QKNP
V
I
K-M
D
D
K
V
---
V
A
E
V
V
S
RNQANSFDQY
N
Y
TMGGAAYS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
95.91
14%
-128
- C6 -
3W3W
1
IMB3_YEAST
A:
[3-1077]
ALP
E
E
V
N
R
T
L
L
Q
I
V
Q
A
FASD
N
Q
I
R
S
V
A
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K
A
L
S
EEWITENN
I
E
Y
L
L
T
F
L
A
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A
A
FSQD
T
T
V
A
A
L
S
A
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L
F
R
K
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PITHIR
K
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L
K
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P
N
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A
----
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--------
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L
GG
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Y
L
A
---
A
P
L
F
Q
Y
L
Q
Q
------------------
M
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---
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L
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--
R
I
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P
A
L
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K
L
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S
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C
T
-------------------
S
-----------------
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V
Q
T
H
A
A
A
A
L
V
N
F
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F
----------
A
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I
L
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Y
L
D
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-------
L
L
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N
L
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K--------
L
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---
K
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----------
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------
K
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------
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---------------
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----------
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L
L
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L
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------
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--
A
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L
IEEEEAANFQQYPD
W
D
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---
V
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A
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L
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-------------
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K
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-----------------
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L
L
Q
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Y
A
T
---------
L
L
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Q
--------
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A
A
G
A
T
L
I
P
I
L
L
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------
C
L
L
A
A
E
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L
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L
L
W
H
K
A
S
S
K
L
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-----
G
G
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P
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T
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LS
E
D
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L
A
--
A
F
T
K
--------
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--
V
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A
N
L
T
D
T
Y
E
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D
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D
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F
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D
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D
L
L
-
D
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I
------
N
K
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L
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T
T
N
G
H
Y
L
K
N
L
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N
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N
T
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L
L
E
----------
P
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V
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F
A
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D
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E
Q
T
A
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M
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N
A
F
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C
L
I
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P
D
A
R
I
R
Q
A
A
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Y
I
I
G
V
C
A
Q
Y
A
P
S
T
-----
Y
A
--
D
V
C
I
P
T
--
L
D
T
L
V
Q
I
V
D
G
S
K
L
E
E
N
R
S
---
S
T
E
N
A
S
A
A
I
A
K
I
L
Y
A
Y
N
S
N
I
P
D
T
Y
T
A
N
W
F
K
T
LPTITD
K
E
A
A
S
F
N
Y
Q
F
L
S
QVCAQSN
I
S
A
V
V
D
S
V
I
Q
A
L
N
E
RSLT
V
I
S
S
V
K
K
L
L
G
F
L
P
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D
A
M
A
I
F
N
RYP
A
D
I
M
E
K
V
H
K
W
F-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
81.85
13%
-121
- C6 -
4BSM
-
XPO1_HUMAN
A:
[3-1017]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A
I
M
T
M
L
A
D
H
A
A
R
Q
L
L
D
F
SQKL
D
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--
K
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---
V
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L
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M
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N
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D
Y
V
D
------
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E
R
--
I
M
T
E
K
L
H
---------------
N
Q
V
N
GTE
W
S
W
K
N
L
N
-----------
T
L
C
W
A
I
G
S
I
SGAMH
E
E
D
E
K
R
F
L
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-----------------
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---------
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L
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A
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Q
-
I
F
D
A
V
F
E
C
T
L
N
M
I
N
K
D
E
Y
P
E
H
R
T
N
F
F
L
L
L
Q
A
V
N
S
H
CFP
P
T
Q
F
K
L
V
L
D
S
I
I
W
A
F
K
HTMRNVA
D
T
G
L
Q
I
L
F
T
L
L
Q
N
VAQEEAAAQSFYQTY
F
C
D
I
L
Q
H
I
F
SVVTNLVEEGKL
Q
E
Y
V
A
NP
A
F
K
E
H
L
R
D----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
69.53
10%
-131
- C6 -
1Z3H
1
CSE1_YEAST
A:
[2-959]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
D
L
E
T
V
A
K
F
L
A
E
S
V
IAST
A
K
T
S
E
R
N
L
R
Q
L
ETQDG
F
G
L
T
L
L
H
V
I
A
STNLP
L
S
T
R
L
A
G
A
L
F
F
K
N
F
I
K
R
K
W
V
D
E
N
G
N
H
L
L
P
A
----
N
N
V
E
L
I
--------
K
K
E
I
V
--
P
L
M
I
---
S
L
P
N
N
L
Q
V
Q
------------------
I
G
E
A
I
S
S
I
A
D
-
S
D
F
P
D
R
W
P
T
L
L
S
D
L
A
S
R
L
-
S
N
---------
D
D
M
V
T
N
---
K
G
V
L
T
V
A
H
S
I
F
-
K
R
W
R
P
L
F
R
S
D
E
L
F
L
E
I
K
--
L
V
L
D
V
F
T
A
P
F
L
N
L
L
K
T
V
D
E
Q
I
T
A
N
E
N
N
K
A
S
L
N
I
L
F
-----------------
D
V
L
L
V
L
I
K
L
Y
Y
D
F
N
-
C
Q
--
D
I
P
E
F
F
E
D
N
I
Q
V
G
M
G
I
F
H
K
-------
Y
L
S
Y
S
N
P
L
L
E
D
P
DETEHAS
V
L
I
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V
K
S
S
I
Q
E
L
V
Q
L
Y
T
T
R
Y
E
D
V
F
G
---
P
M
I
----------
N
E
F
I
Q
I
T
W
N
L
L
T
S
ISNQ
P
K
Y
------
D
I
L
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S
K
S
L
S
F
L
T
A
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T
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--
K
Y
F
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I
F
-------------
N
N
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A
M
N
N
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Q
----------
I
I
L
P
N
V
T
L
R
E
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D
V
E
L
F
E
D
---------------
D
P
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I
-
R
R
D
L
EGSDTDT
R
R
R
A
C
T
D
F
L
K
E
L
-
K
E
K
------
N
E
V
--
L
V
T
N
I
F
L
---------------
A
H
M
K
---
G
F
V
D
Q
Y
M
S
DPSKNW
K
F
K
D
L
Y
I
Y
L
F
T
-------------
A
L
A
I
NGNITNAGVSSTNNLLN
V
V
D
F
F
T
K
E
I
A
---------
P
D
L
T
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NNIPH
I
I
L
R
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D
A
I
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Y
I
Y
T
F
R
N
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--
K
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P
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L
A
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F
L
Q
T
D
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------
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V
Y
T
Y
A
A
I
T
I
E
K
I
L
T
I
R
E
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S
-----
N
S
T
E
I
---------
L
L
K
N
L
I
A
L
I
L
K
H
G
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S
P
--
E
K
L
A
E
N
E
F
L
M
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--------
S
--
I
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L
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S
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P
L
F
P
Q
L
L
A
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T
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A
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T
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N
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L
L
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M
M
P
T
F
L
T
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--
F
S
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I
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-
I
I
A
F
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P
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A
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L
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A
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L
L
K
S
F
I
K
T
D
S
-----
S
I
FP
D
L
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P
V
L
G
I
F
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R
L
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A
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K
A
Y
E
V
-
H
G
F
D
L
---
L
E
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L
L
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M
N
R
L
R
P
Y
I
K
Q
I
A
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L
L
L
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R
L
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NSKT
E
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Y
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K
L
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F
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L
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D
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L
F
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FIITTLPTIGN
L
L
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K
I
A
L
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V
L
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NGQFFQSKYPTL
I
S
S
T
M
N
S
I
I
E
T
A
S
SQSGSHFSKLVSISEKPFDPLPEIDVNNG
V
R
L
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V
A
E
A
L
N
K
Y
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A
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F
L
N
T
I
L
PQLT
Q
E
N
Q
V
K
L
N
Q
L
L
V
G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
68.16
9%
-110
* C6 *
1U6G
-
CAND1_HUMAN
C:
[4-1210]
-----------------------------------------------------------------------------------------ASY
H
I
S
N
L
L
E
K
M
T
SSD
K
D
F
R
F
M
A
T
N
D
L
M
T
E
L
Q
KDSIKLD
D
D
S
E
R
K
V
V
K
M
I
L
K
L
LEDKN
G
E
V
Q
N
L
A
V
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C
L
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P
L
V
S
K
VK
E
Y
Q
V
E
T
I
V
D
T
L
C
T
N
MLSDKE
Q
L
R
D
I
S
S
I
G
L
K
T
V
I
G
E
LPSALAANV
C
K
K
I
T
G
R
L
T
S
A
I
AKQED
V
S
V
Q
L
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A
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M
A
D
M
L
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R
QGGLLVNF
H
P
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L
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LTSPR
L
A
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R
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MSCFVDL
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L
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T
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C
I
A
A
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S
R
Q
A
G
H
R
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Y
L
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----
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L
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--------
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N
V
D
D
--
D
E
L
R
---
E
Y
C
I
Q
A
F
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S
------------------
F
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Y
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------
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R
R
A
A
A
K
C
L
---
D
A
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T
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M
L
-
P
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F
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--
R
E
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A
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T
M
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Q
V
-----------------
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-----------------------------------
N
I
-------
V
K
A
L
H
K
Q
M
K
E
K
S
---------
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K
T
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C
C
F
N
M
L
T
E
L
V
N
V
L
P
G
A
L
T
---
Q
H
I
----------
P
V
L
V
P
G
I
I
F
S
L
------
N
D
K
------
S
S
S
S
N
L
K
I
D
A
L
S
C
L
Y
V
I
L
--
C
N
H
S
---------------
P
--
Q
V
F
H
P
H
V
Q
A
----------
L
V
P
P
V
V
A
C
V
G
D
P
F
Y
K
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---------------
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A
L
L
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T
-
Q
Q
----------
L
V
K
V
I
R
P
L
D
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-------------------
P
S
S
F
---------------
D
A
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P
---
Y
I
K
D
L
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-----------
C
T
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K
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L
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-------------
A
A
D
I
-----------------
D
Q
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V
K
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A
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---------
C
M
G
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--------
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C
N
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--
Q
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A
L
------
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L
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A
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L
G
E
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-----
P
I
L
A
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---------
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L
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A
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L
G
T
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--
L
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--
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--------
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T
A
A
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A
V
L
D
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L
P
P
L
---
I
S
E
S
D
M
-
H
V
S
-
Q
M
A
------
I
S
F
L
T
T
L
A
K
V
Y
P
S
S
L
S
K
I
S
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S
I
L
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L
--
I
G
L
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R
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P
L
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--
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----
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-
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N
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-
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---
A
L
L
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I
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A
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L
P
F
V
L
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T
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QPKR
Q
Y
L
L
L
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S
L
K
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V
E
N
I
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A
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L
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E
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V
A
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L
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L
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R
L
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YLISGS
S
Y
A
R
S
S
V
V
T
A
V
K
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T
ISDHPQPI
D
P
L
L
K
N
C
I
G
D
F
L
K
TLEDPDLN
V
R
R
V
A
L
V
T
F
N
S
A
A
H
NKPSLIRDLLDTV
L
P
H
L
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N
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KVRKEL
I
R
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E
M
GP
F
K
H
T
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L
D
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A
A
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T
L
L
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SCLDRLD
I
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KDH
Y
D
I
K
M
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L
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L
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R
L
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CP
S
A
V
L
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R
L
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A
A
L
L
T
IPEAEKSPLMSEFQ
S
Q
I
S
S
N
P
E
L
A
A
34
Fugue
67.77
9%
-114
- C6 -
3IBV
2
XPOT_SCHPO
A:
[3-977]
------------------------------------------------------------------------------------------------M
S
A
Q
D
V
E
N
A
V
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A
A
L
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P
I
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WNNESN
L
L
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A
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L
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F
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A
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S
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--
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P
L
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L
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------------------
L
N
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L
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L
N
L
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--
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-
Y
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-------
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S
L
S
T
A
A
T
L
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---------
P
E
N
S
W
Q
L
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F
A
L
Y
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Y
I
F
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L
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---
G
P
D
AFFNEVDKSP
T
V
L
S
Q
I
L
A
L
V
T
------
T
S
Q
VCRHPH
P
L
V
Q
L
L
Y
M
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I
L
V
R
Y
A
S
F
F
--
D
Y
E
S
A
A
-------------
I
--
P
A
L
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F
V
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PRGIHNTNER
V
R
P
R
A
W
Y
L
F
Y
R
F
V
K
S
I
K
K
---------------
Q
V
V
N
Y
T
-
E
S
----------
S
L
A
M
L
G
D
L
L
N
I
-
S
V
S
P
V
TDAP
V
P
T
--
L
N
S
S
I
R
N
---------------
S
D
F
N
---
S
Q
L
Y
L
F
E
-----------
T
V
G
V
L
I
S
-------------
S
G
N
L
-----------------
T
P
E
E
Q
A
L
Y
C
D
---------
S
L
I
N
A
--------
L
I
G
K
A
N
A
A
L
S
S
D
L
S
E
N
--
I
I
S
V
Y
C
S
L
M
A
I
G
N
F
A
K
G
F
P
A
RGEEV
A
W
L
A
S
F
N
K
A
S
D
E
I
F
L
I
L
D
R
M
G
-----
F
N
E
D
I
---------
R
G
A
V
R
F
T
S
G
R
I
I
N
V
V
G
--
P
D
M
L
P
--
K
V
P
Q
--------
L
--
I
S
I
L
L
N
S
I
D
M
N
E
L
V
D
V
L
S
F
I
S
Q
L
I
-
H
I
Y
K
D
N
M
------
M
E
I
T
N
R
M
L
P
T
L
L
M
R
I
F
S
S
L
S
A
T
D
D
A
V
--
K
Q
N
D
L
R
K
S
Y
--
I
S
F
I
L
Q
L
L
N
K
G
F
G
S
-
I
L
F
T
E
E
N
Q
V
Y
F
D
P
L
I
N
S
I
L
H
F
A
P
A
T
Q
K
-
S
S
I
A
L
V
S
K
M
V
S
L
A
G
F
E
N
F
T
L
S
L
T
-----
P
L
--
C
F
E
M
P
V
N
L
V
V
L
G
E
L
A
G
L
Q
K
I
-
I
L
E
K
L
---
G
D
I
Y
K
S
Y
L
V
T
V
Y
F
P
T
D
V
M
A
S
E
Y
L
Q
A
I
QALKS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
64.33
10%
-127
* C5 *
2PFT
-
EXOC7_MOUSE
A:
[85-652]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
I
S
Y
Y
H
V
A
----
S
D
T
E
K
I
--------
I
R
E
G
P
--
T
G
R
L
---
E
E
Y
L
G
S
M
A
K
------------------
I
Q
K
A
V
E
Y
F
Q
D
-
N
S
P
D
S
--------------
P
E
L
N
K
V
K
L
L
F
E
R
G
K
E
S
L
---
E
S
E
F
R
S
L
M
T
R
H
-
S
K
V
V
S
P
V
L
L
L
D
L
I
S
A
D
D
--
E
L
E
H
L
P
E
S
V
L
R
D
V
V
R
I
S
R
W
L
V
E
Y
G
R
N
Q
D
F
M
N
V
Y
Y
Q
-----------------
I
R
S
S
Q
L
D
R
S
I
K
G
L
K
E
H
F
--
R
K
------
S
L
D
V
E
T
D
A
Y
I
H
-------
C
V
S
A
F
V
K
L
A
Q
S
E
---------
Y
R
L
L
M
E
I
I
P
E
H
H
Q
K
K
T
F
D
S
L
I
Q
D
---
A
L
D
----------
G
L
M
L
E
G
E
N
I
V
S
------
A
A
R
------
K
A
I
I
R
H
D
F
S
T
V
L
T
V
F
P
I
L
--
R
H
L
K
Q
T
-------------
K
--
P
E
F
D
Q
V
L
Q
G
----------
T
A
A
S
T
K
N
K
L
P
G
L
I
T
S
M
E
T
---------------
I
G
A
K
A
L
-
E
D
----------
F
A
D
N
I
K
N
D
P
D
K
-
E
Y
N
------
M
P
K
DG
T
V
H
E
L
T
S
---------------
N
A
I
L
---
F
L
Q
Q
L
L
D
-----------
F
Q
E
T
A
G
A
-------------
M
L
A
S
-----------------
Q
-
E
S
S
E
F
S
K
R
---------
L
L
S
T
Y
--------
I
C
K
V
L
G
N
L
Q
L
N
L
L
S
K
S
--
K
V
Y
E
D
P
A
L
S
A
I
F
L
H
N
N
Y
N
Y
I
------
L
K
S
L
E
K
S
E
L
I
Q
L
V
A
V
T
Q
K
-----------
T
---------
A
E
R
S
Y
R
E
H
I
E
Q
Q
I
Q
T
Y
--
Q
R
S
W
L
--
K
V
T
D
--------
Y
--
I
A
E
K
N
L
P
V
F
Q
P
G
V
K
L
R
D
K
E
R
Q
M
I
K
-
E
R
F
-
K
G
F
------
N
D
G
L
E
E
L
C
K
I
Q
K
V
W
----------------------------
A
I
P
-----------------
D
T
E
Q
R
D
K
I
R
Q
A
Q
K
D
I
V
K
E
T
-
Y
G
A
F
L
H
R
Y
G
S
V
P
F
T
K
N
P
E
K
Y
I
K
Y
---------
R
V
E
Q
V
G
D
M
I
D
R
L
F
D
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
63.64
7%
-109
- C5 -
1T0Q
4
?
A:
[2-492]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
L
K
R
E
D
W
Y
D
L
T
----
R
T
-
T
N
W
--------
T
P
K
Y
V
--
T
E
N
E
---
L
F
P
E
E
M
S
G
A
------------------
R
G
I
S
M
E
A
W
E
K
Y
D
E
P
Y
K
I
T
-----------------------------------------------
Y
P
E
Y
V
S
I
Q
R
E
K
D
S
G
--
A
Y
S
I
K
A
A
L
E
R
D
G
F
V
D
R
A
D
P
G
W
V
S
T
M
Q
L
H
F
G
A
I
A
L
E
-----------------
E
Y
A
A
S
T
A
E
A
R
M
A
R
F
A
K
A
--
P
G
N
R
N
M
A
T
F
G
M
M
D
E
N
R
H
G
Q
-------
I
Q
L
Y
F
P
Y
A
N
V
K
R
-------------
S
R
K
W
D
W
A
H
K
A
I
H
T
N
E
W
A
A
I
---
A
A
R
----------
S
F
F
D
D
M
M
M
T
R
D
------
S
V
A
------
V
S
I
M
L
T
F
A
F
E
T
G
F
T
N
M
Q
F
--
L
G
L
A
A
D
-------------
A
--
A
E
A
G
D
H
T
F
A
----------
S
L
I
S
S
I
Q
T
D
E
S
R
H
A
Q
Q
G
G
---------------
P
S
L
K
I
L
-
V
E
----------
N
G
K
----------------------------
K
D
---------------
E
A
Q
Q
---
M
V
D
V
A
I
W
-----------
R
S
W
K
L
F
S
-------------
V
L
T
G
-----------------
P
I
M
D
Y
Y
T
P
L
E
---------
S
R
N
Q
S
--------
F
K
E
F
M
L
E
W
I
V
A
Q
F
E
R
Q
--
L
L
D
L
G
L
D
K
P
------
W
Y
W
D
Q
------
F
M
Q
D
L
D
E
T
H
H
G
M
H
L
G
V
W
Y
W
R
-----
P
T
V
W
W
---------
D
P
A
A
G
V
S
--------------------------------------
P
E
E
R
E
W
L
E
E
K
Y
P
G
W
N
D
T
W
G
-
Q
C
W
-
D
V
I
------
T
D
N
L
V
N
--------------
G
K
P
E
L
T
--
V
P
E
T
L
P
T
I
C
--
N
M
C
N
L
P
I
A
H
T
P
G
N
K
-
W
N
V
K
D
Y
Q
L
E
Y
E
G
R
L
Y
H
F
G
S
E
A
D
R
W
C
F
Q
-
I
D
------
P
E
R
Y
K
N
H
T
N
L
V
D
R
F
L
-----
K
G
--
E
I
Q
P
A
D
L
A
G
A
L
M
Y
-----
M
S
-
L
E
P
G
V
---
M
G
D
----------
D
A
H
D
Y
E
W
V
K
A
Y
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
61.40
26%
-18
- C4 -
2AQI
1
INHA_MYCTU
A:
[2-119]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
L
D
G
K
R
I
L
V
S
G
I
--
I
T
D
S
S
--
I
A
F
H
I
A
R
V
A
Q
E
Q
G
--
A
Q
L
V
L
T
G
-
F
D
R
L
R
-----
L
T
Q
R
I
T
-
D
R
L
-
P
A
K
------
A
P
L
L
E
L
D
V
Q
N
E
E
H
L
A
S
L
A
G
R
-
V
T
E
A
I
--
G
A
G
N
K
L
D
G
V
V
H
S
I
G
F
M
P
Q
T
G
M
G
I
N
P
F
F
D
A
P
Y
A
D
V
S
K
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
58.19
26%
-14
- C4 -
4R9S
2
?
A:
[5-111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
L
D
G
K
R
I
L
V
S
G
I
--
I
T
D
S
S
--
I
A
F
H
I
A
R
V
A
Q
E
Q
G
--
A
Q
L
V
L
T
G
-
F
D
R
L
R
-----
L
I
Q
R
I
T
-
D
R
L
-
P
A
K
------
A
P
L
L
E
L
D
V
Q
N
E
E
H
L
A
S
L
A
G
R
-
V
T
E
A
I
--
G
A
G
N
K
L
D
G
V
V
H
S
I
G
F
M
P
Q
T
G
M
G
I
N
P
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
57.62
26%
-27
- C4 -
5CP8
4
?
A:
[23-128]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
L
D
G
K
R
I
L
V
S
G
I
--
I
T
D
S
S
--
I
A
F
H
I
A
R
V
A
Q
E
Q
G
--
A
Q
L
V
L
T
G
-
F
D
R
L
R
-----
L
I
Q
R
I
T
-
D
R
L
-
P
A
K
------
A
P
L
L
E
L
D
V
Q
N
E
E
H
L
A
S
L
A
G
R
-
V
T
E
A
I
--
G
A
G
N
K
L
D
G
V
V
H
S
I
G
F
M
P
Q
T
G
M
G
I
N
P
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
57.55
25%
-22
- C4 -
2AQH
1
INHA_MYCTU
A:
[2-119]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
L
D
G
K
R
I
L
V
S
G
I
--
I
T
D
S
S
--
V
A
F
H
I
A
R
V
A
Q
E
Q
G
--
A
Q
L
V
L
T
G
-
F
D
R
L
R
-----
L
I
Q
R
I
T
-
D
R
L
-
P
A
K
------
A
P
L
L
E
L
D
V
Q
N
E
E
H
L
A
S
L
A
G
R
-
V
T
E
A
I
--
G
A
G
N
K
L
D
G
V
VH
S
I
G
F
M
P
Q
T
G
M
G
I
N
P
F
F
D
A
P
Y
A
D
V
S
K
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
57.40
26%
-25
- C4 -
3OF2
2
INHA_MYCTU
A:
[3-108]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
L
D
G
K
R
I
L
V
S
G
I
--
I
T
D
S
S
--
I
A
F
H
I
A
R
V
A
Q
E
Q
G
--
A
Q
L
V
L
T
G
-
F
D
R
L
R
-----
L
I
Q
R
I
T
-
D
R
L
-
P
A
K
------
A
P
L
L
E
L
D
V
Q
N
E
E
H
L
A
S
L
A
G
R
-
V
T
E
A
I
--
G
A
G
N
K
L
D
G
V
V
H
S
I
G
F
M
P
Q
T
G
M
G
I
N
P
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
57.34
26%
-23
- C4 -
4R9R
2
?
A:
[6-111]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
L
D
G
K
R
I
L
V
S
G
I
--
I
T
D
S
S
--
I
A
F
H
I
A
R
V
A
Q
E
Q
G
--
A
Q
L
V
L
T
G
-
F
D
R
L
R
-----
L
I
Q
R
I
T
-
D
R
L
-
P
A
K
------
A
P
L
L
E
L
D
V
Q
N
E
E
H
L
A
S
L
A
G
R
-
V
T
E
A
I
--
G
A
G
N
K
L
D
G
V
V
H
S
I
G
F
M
P
Q
T
G
M
G
I
N
P
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
57.32
26%
-24
- C4 -
4OXY
2
INHA_MYCTU
A:
[22-128]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
L
D
G
K
R
I
L
V
S
G
I
--
I
T
D
S
S
--
I
A
F
H
I
A
R
V
A
Q
E
Q
G
--
A
Q
L
V
L
T
G
-
F
D
R
L
R
-----
L
I
Q
R
I
T
-
D
R
L
-
P
A
K
------
A
P
L
L
E
L
D
V
Q
N
E
E
H
L
A
S
L
A
G
R
-
V
T
E
A
I
--
G
A
G
N
K
L
D
G
V
V
H
S
I
G
F
M
P
Q
T
G
M
G
I
N
P
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
57.20
26%
-23
- C4 -
4OXN
5
INHA_MYCTU
A:
[22-135]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
L
D
G
K
R
I
L
V
S
G
I
--
I
T
D
S
S
--
I
A
F
H
I
A
R
V
A
Q
E
Q
G
--
A
Q
L
V
L
T
G
-
F
D
R
L
R
-----
L
I
Q
R
I
T
-
D
R
L
-
P
A
K
------
A
P
L
L
E
L
D
V
Q
N
E
E
H
L
A
S
L
A
G
R
-
V
T
E
A
I
--
G
A
G
N
K
L
D
G
V
V
H
S
I
G
F
M
P
Q
T
G
M
G
I
N
P
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
57.20
26%
-22
- C4 -
4OXK
2
INHA_MYCTU
A:
[23-128]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
L
D
G
K
R
I
L
V
S
G
I
--
I
T
D
S
S
--
I
A
F
H
I
A
R
V
A
Q
E
Q
G
--
A
Q
L
V
L
T
G
-
F
D
R
L
R
-----
L
I
Q
R
I
T
-
D
R
L
-
P
A
K
------
A
P
L
L
E
L
D
V
Q
N
E
E
H
L
A
S
L
A
G
R
-
V
T
E
A
I
--
G
A
G
N
K
L
D
G
V
V
H
S
I
G
F
M
P
Q
T
G
M
G
I
N
P
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
57.14
26%
-20
- C4 -
4OHU
2
INHA_MYCTU
A:
[23-128]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
L
D
G
K
R
I
L
V
S
G
I
--
I
T
D
S
S
--
I
A
F
H
I
A
R
V
A
Q
E
Q
G
--
A
Q
L
V
L
T
G
-
F
D
R
L
R
-----
L
I
Q
R
I
T
-
D
R
L
-
P
A
K
------
A
P
L
L
E
L
D
V
Q
N
E
E
H
L
A
S
L
A
G
R
-
V
T
E
A
I
--
G
A
G
N
K
L
D
G
V
V
H
S
I
G
F
M
P
Q
T
G
M
G
I
N
P
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
57.11
26%
-19
- C4 -
4OYR
2
INHA_MYCTU
A:
[23-128]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
L
D
G
K
R
I
L
V
S
G
I
--
I
T
D
S
S
--
I
A
F
H
I
A
R
V
A
Q
E
Q
G
--
A
Q
L
V
L
T
G
-
F
D
R
L
R
-----
L
I
Q
R
I
T
-
D
R
L
-
P
A
K
------
A
P
L
L
E
L
D
V
Q
N
E
E
H
L
A
S
L
A
G
R
-
V
T
E
A
I
--
G
A
G
N
K
L
D
G
V
V
H
S
I
G
F
M
P
Q
T
G
M
G
I
N
P
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
57.00
26%
-27
- C4 -
3OEY
2
INHA_MYCTU
A:
[3-108]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
L
D
G
K
R
I
L
V
S
G
I
--
I
T
D
S
S
--
I
A
F
H
I
A
R
V
A
Q
E
Q
G
--
A
Q
L
V
L
T
G
-
F
D
R
L
R
-----
L
I
Q
R
I
T
-
D
R
L
-
P
A
K
------
A
P
L
L
E
L
D
V
Q
N
E
E
H
L
A
S
L
A
G
R
-
V
T
E
A
I
--
G
A
G
N
K
L
D
G
V
V
H
S
I
G
F
M
P
Q
T
G
M
G
I
N
P
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
56.78
26%
-27
* C4 *
1P45
3
INHA_MYCTU
A:
[2-108]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
L
D
G
K
R
I
L
V
S
G
I
--
I
T
D
S
S
--
I
A
F
H
I
A
R
V
A
Q
E
Q
G
--
A
Q
L
V
L
T
G
-
F
D
R
L
R
-----
L
I
Q
R
I
T
-
D
R
L
-
P
A
K
------
A
P
L
L
E
L
D
V
Q
N
E
E
H
L
A
S
L
A
G
R
-
V
T
E
A
I
--
G
A
G
N
K
L
D
G
V
V
H
S
I
G
F
M
P
Q
T
G
M
G
I
N
P
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------