@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0330: (2016-03-14 )
LLVEELKTKYLVKDICQILQVPLSTYYRWKKKDFSQSSLEKKIGQLCKAYQFTYGYRKIAALMKQEEQVGINKVQRIMQKYQWQCQVKVKKKNRPGSAYYQTENHLNRNFQASQPLEKLTTDITYLYFGDCRLYLSSIMDLYNGEIVAYSIGEKQDTELVLDTLNQLSLPEGSLLHSDQGSVYTSYEYYQCCKKKNVIRSMSRKGTPADNAPIECFHSSLKCETFYHKTAYKYAKSIVIQIVKDYIKYYNEKRIQQKLGYQSPINFRKQAA
Atome Classification :
(20 SA)
----------------------.........10........20......---..30........40........50........60.....--...70.---.......80........90........100.......110-----------------------------------........120-.-..-....130...---------.-...140...-----....150.---------------------......160......--------..--.170.-----......180.......190.......200.......210-----------.......220.......230.------......240.....--..250.......260.......270
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------L
L
V
E
E
L
K
T
K
Y
L
V
K
D
I
C
Q
I
L
Q
V
P
L
S
T
Y
Y
---
R
W
KKKDF
S
Q
S
S
L
E
K
K
I
G
Q
L
C
K
A
Y
Q
F
T
Y
G
Y
R
K
I
A
A
L
M
K
Q
E
--
E
QV
G
I
N
---
K
V
Q
R
I
M
Q
KY
Q
W
Q
C
Q
V
K
V
K
KKNRPGS
A
Y
Y
Q
TENHLNRNFQ------------------------------------ASQ
P
L
E
K
L
TTD-
I
-
T
Y
-
L
Y
FG
D
C
R
L
Y
L
---------
S
-
S
I
M
D
L
YNG
E
-----
I
V
A
Y
SIGE---------------------KQ
D
T
E
L
V
--
L
D
T
L
N
Q--------LS--LPEGS-----LLHSDQG
S
V
Y
T
S
Y
E
Y
Y
Q
C
C
K
K
K
N
V
I
R
S
M
SRKGTPADNA
P
-----------
I
E
C
F
H
SSL
K
C
E
T
F
Y
H
K
T
A
Y
K
Y
------
A
K
S
I
V
I
Q
I
V
K
D
Y
I
K
--
Y
Y
N
E
K
R
I
Q
Q
KLGYQSPINFRKQAA
25
HHSearch
72.37
17%
-37
* C2 *
3F9K
-
POL_HV2RO
A:
[11-202]
---------------------------------------------------------------------------
E
E
H
E
K
Y
H
S
N
V
K
E
L
S
H
K
F
-
G
I
P
N
L
V
----
A
R
Q
I
V
N
S
C
A
Q
C
Q
Q
K
G
E
A
I
-----------------
H
G
Q
------------------------------------
V
N
A
E
L
G
T
W
Q
M
D
-
C
-
T
H
-
L
----
E
G
K
I
I
---------
I
-
V
A
V
H
V
A
S
G
F
-----
I
E
A
E
V
I
P
Q
----------------------
E
S
G
R
Q
T
--
A
L
F
L
L
K
--------
L
A
S
R
W
P
I
T
------
H
L
H
T
D
N
G
A
N
F
T
S
Q
E
V
K
M
V
A
W
W
I
G
I
E
Q
S
F
G
V
P
Y
N
P
Q
S
Q
G
V
-----------
V
E
A
M
N
H
H
L
K
N
Q
I
S
R
I
R
E
----------
Q
A
N
T
I
E
T
I
V
L
M
A
V
H
--
C
M
N
F
-
K
R
R
G
G
I
G
D
M
T
P
S
E
R
L
I
---
22
HHSearch
70.51
17%
-39
- C2 -
3OYM
8
POL_FOAMV
A:
[53-272]
------------------------------------------------------------
P
Q
S
D
R
Q
K
I
V
L
Q
A
H
N
-
L
A
H
T
G
R
E
A
T
L
L
K
I
A
N
L
YW
W
P
N
M
R
K
---
D
V
V
K
Q
L
G
R
C
Q
Q
C
L
I
T
N
A
S
N
K
A
S
G
---------
P
I
L
R
P
D
R
------------------------------------
P
Q
K
P
F
D
K
F
F
I
D
-
Y
-
I
G
P
L
P
P
S
Q
G
Y
L
Y
V
---------
L
-
V
V
V
D
G
M
T
G
F
-----
T
W
L
Y
P
T
K
A
----------------------
P
S
T
S
A
T
--
V
K
S
L
-
N
--------
V
L
T
S
I
A
I
P
K
-----
V
I
H
S
D
Q
G
A
A
F
T
S
S
T
F
A
E
W
A
K
E
R
G
I
H
L
E
F
S
T
P
Y
H
P
Q
S
S
G
K
-----------
V
E
R
K
H
S
D
I
K
R
L
L
T
K
L
L
V
---
G
------
R
P
T
K
W
Y
D
L
L
P
V
V
Q
L
--
A
L
N
N
-
T
Y
S
P
V
L
K
-
Y
T
P
H
Q
L
L
----
27
HHSearch
68.80
16%
-65
- C2 -
1CXQ
3
A:
[7-151]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
P
L
Q
I
W
Q
T
D
-
F
-
T
L
-
E
P
R
M
A
P
R
S
W
L
---------
A
-
V
T
V
D
T
A
S
S
A
-----
I
V
V
T
Q
H
G
R
----------------------
V
T
S
V
A
A
--
Q
H
H
W
A
T
--------
A
I
A
V
L
G
R
P
K
-----
A
I
K
T
D
N
G
S
C
F
T
S
K
S
T
R
E
W
L
A
R
W
G
I
A
H
T
T
G
I
P
G
----
Q
A
M
-----------
V
E
R
A
N
R
L
L
K
D
K
I
R
V
L
A
E
--
G
D
GFMKRI
P
T
S
K
Q
G
E
L
L
A
K
A
M
Y
--
A
L
N
H
--------------------
47
Fugue
67.28
21%
-2
- C2 -
4HHT
4
RNH2_THEMA
A:
[1-229]
----------------------------------------------
G
I
D
---
E
L
Y
K
K
E
F
G
I
V
A
G
V
D
E
A
S
R
G
C
L
A
-----
G
P
V
V
A
A
A
V
V
L
E
K
--
E
I
E
G
I
N
DSR
L
L
D
E
I
M
E
K
A
A
V
G
I
G
I
A
S
P
E
E
I
D
L
Y
N
I
F
N
A
T
K
L
A
M
N
R
A
L
E
------------------------------------
N
------
L
S
V
K
-
P
-
S
F
-
V
L
V
D
G
K
G
I
E
L
---------
S
V
P
G
T
C
L
V
K
G
D
QKS
K
L
I
G
A
A
S
I
V
A
---------------------
K
V
F
R
D
R
L
--
M
S
E
F
H
R
--------
M
Y
----
P
Q
F
-----
S
F
H
K
H
K
G
--
Y
A
T
K
E
H
L
N
E
I
R
K
N
G
V
-----
L
P
I
H
R
L
S
F
E
P
-----------
V
L
E
L
L
T
D
D
L
L
R
E
F
F
E
K
---------------------
G
L
I
S
--
E
N
R
F
E
R
I
L
N
L
L
G
A
R
K
S
V
V
F
R
K
E
R
-
31
HHSearch
66.81
18%
-49
- C2 -
3KKS
2
POL_BIV29
A:
[2-144]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
L
W
Q
M
D
-
N
-
T
H
-
W
----
N
K
T
I
I
---------
W
-
V
A
V
E
T
N
S
G
L
-----
V
E
A
Q
V
I
P
E
----------------------
E
T
A
L
Q
V
--
A
L
C
I
L
Q
--------
L
I
Q
R
Y
T
V
-
L
-----
H
L
H
S
D
N
G
P
C
F
T
A
H
R
I
E
N
L
C
K
Y
L
G
I
T
K
T
T
G
I
P
Y
N
P
Q
S
Q
G
V
-----------
V
E
R
A
H
R
D
L
K
D
R
L
A
A
Y
Q
----
G
------
D
C
E
T
V
E
A
A
L
S
L
A
L
V
--
S
L
N
K
-
K
R
G
G
-
I
G
G
H
T
P
Y
E
I
Y
L
---
46
Fugue
65.38
17%
-22
- C2 -
3BTP
4
VIRE2_AGRFC
A:
[112-517]
RRTDE
Y
I
L
V
R
Q
TGQD
K
F
A
G
T
T
K
C
N
L
D
H
L
P
T
K
A
E
F
N
A
S
C
R
L
Y
R
D
G
V
G
N
Y
Y
P
P
P
L
A
F
E
R
I
D
L
P
E
Q
L
A
A
Q
L
L
E
P
R
E
Q
S
K
Q
C
F
Q
Y
K
L
E
V
W
N
R
A
H
A
--
E
M
-
G
I
T
---
G
-
T
D
I
F
Y
Q
T
D
K
N
I
K
L
D
R
N
Y
K
L
R
P
E
D
R
Y
I
Q
T
E
K
Y
G
R
R
E
I
Q
KRYEHQFQAGSLLPD
I
L
I
K
T
PQN
D
I
H
F
S
Y
R
F
AGDAY
A
N
K
R
F
E
E
F
E
R
A
-
I
-
K
T
-
K
Y
G
S
D
T
E
I
K
L
K
S
KSGIMHD
S
-
K
Y
L
E
S
W
E
R
G
-----
S
A
D
I
R
F
A
E
F
A
GENRAQFPA
A
T
V
N
MGRQPM
T
R
D
R
H
V
S
--
V
D
Y
L
L
Q
N
LPNS
P
W
T
Q
A
--
L
K
E
G
K
LWDR
V
Q
V
L
A
R
D
G
N
R
Y
M
S
P
S
R
L
E
Y
S
D
P
E
H
F
T
Q
L
M
D
Q
V
G
L
P
V
S
M
G
R
QSHAFDRQAA
V
I
V
A
D
G
P
N
L
R
E
V
P
D
L
S
P
E
K
L
S
Q
------
K
D
V
L
I
A
D
R
N
E
K
G
Q
R
TG
T
Y
T
N
V
V
E
Y
E
R
L
M
M
K
L
P
S
D
A
A
Q
L
L
A
15
PsiBlast_PDB
62.61
23%
-35
- C2 -
3OS1
4
POL_FOAMV
A:
[117-231]
-----------------------------------------------------------------------------------------------------------------------------------------
R
P
D
R
------------------------------------
P
Q
K
P
F
D
K
F
F
I
D
Y
I
-
G
P
-
L
P
P
S
Q
G
Y
L
Y
V
---------
L
-
V
V
V
D
G
M
T
G
F
-----
T
W
L
Y
P
T
K
A
---------------------
P
S
T
S
A
T
V
K
S
L
N
V
L
T
S
--------
I
A
--
I
P
K
-------
V
I
H
S
D
Q
G
A
A
F
T
S
S
T
F
A
E
W
A
K
E
R
G
I
H
L
E
F
S
T
P
Y
H
P
Q
S
S
G
K
-----------
V
E
R
K
N
S
D
I
K
----------------------------------------------------------
14
PsiBlast_PDB
62.11
23%
-39
- C2 -
3OS0
5
POL_FOAMV
A:
[117-231]
-----------------------------------------------------------------------------------------------------------------------------------------
R
P
D
R
------------------------------------
P
Q
K
P
F
D
K
F
F
I
D
Y
I
-
G
P
-
L
P
P
S
Q
G
Y
L
Y
V
---------
L
-
V
V
V
D
G
M
T
G
F
-----
T
W
L
Y
P
T
K
A
---------------------
P
S
T
S
A
T
V
K
S
L
N
V
L
T
S
--------
I
A
--
I
P
K
-------
V
I
H
S
D
Q
G
A
A
F
T
S
S
T
F
A
E
W
A
K
E
R
G
I
H
L
E
F
S
T
P
Y
H
P
Q
S
S
G
K
-----------
V
E
R
K
N
S
D
I
K
----------------------------------------------------------
26
HHSearch
61.45
18%
-54
- C2 -
1K6Y
1
POL_HV1N5
A:
[56-202]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
S
P
G
I
W
Q
L
D
-
C
-
T
H
-
L
----
E
G
K
V
I
---------
L
-
V
A
V
H
V
A
S
G
Y
-----
I
E
A
E
V
I
P
A
----------------------
E
T
G
Q
E
T
--
A
Y
F
L
L
K
--------
L
A
G
R
W
P
-
V
K
-----
T
V
H
T
D
N
G
S
N
F
T
S
T
T
V
K
A
A
C
D
W
A
G
I
K
Q
E
D
---------
G
V
-----------
I
E
S
M
N
K
E
L
K
K
I
I
G
Q
V
R
----
D
------
Q
A
E
H
L
K
T
A
V
Q
M
A
V
F
--
I
H
N
K
-
K
R
K
G
G
I
G
G
Y
S
A
G
E
R
I
V
D
--
28
HHSearch
61.22
18%
-60
- C2 -
1C6V
-
POL_SIVM1
A:
[55-202]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
D
L
G
T
W
Q
M
D
-
C
-
T
H
-
L
----
E
G
K
I
V
---------
I
-
V
A
V
H
V
A
S
G
F
-----
I
E
A
E
V
I
P
Q
----------------------
E
T
G
R
Q
T
--
A
L
F
L
L
K
--------
L
A
G
R
W
P
I
T
------
H
L
H
T
D
N
G
A
N
F
A
S
Q
E
V
K
M
V
A
W
W
A
G
I
E
H
T
F
G
----------------------
E
A
M
N
H
H
L
K
N
Q
I
D
R
I
R
E
----------
Q
A
N
S
V
E
T
I
V
L
M
A
V
H
--
C
M
N
H
-
K
R
R
G
G
I
G
D
M
T
P
A
E
R
L
I
N
--
17
PsiBlast_PDB
61.19
23%
-35
- C2 -
3OYB
8
POL_FOAMV
A:
[117-231]
-----------------------------------------------------------------------------------------------------------------------------------------
R
P
D
R
------------------------------------
P
Q
K
P
F
D
K
F
F
I
D
Y
I
-
G
P
-
L
P
P
S
Q
G
Y
L
Y
V
---------
L
-
V
V
V
D
G
M
T
G
F
-----
T
W
L
Y
P
T
K
A
---------------------
P
S
T
S
A
T
V
K
S
L
N
V
L
T
S
--------
I
A
--
I
P
K
-------
V
I
H
S
D
Q
G
A
A
F
T
S
S
T
F
A
E
W
A
K
E
R
G
I
H
L
E
F
S
T
P
Y
H
P
Q
S
S
G
K
-----------
V
E
R
K
N
S
D
I
K
----------------------------------------------------------
3
PsiBlast_PDB
61.10
24%
-36
- C2 -
3S3O
9
POL_FOAMV
A:
[117-231]
-----------------------------------------------------------------------------------------------------------------------------------------
R
P
D
R
------------------------------------
P
Q
K
P
F
D
K
F
F
I
D
Y
I
-
G
P
-
L
P
P
S
Q
G
Y
L
Y
V
---------
L
-
V
V
V
D
G
M
T
G
F
-----
T
W
L
Y
P
T
K
A
---------------------
P
S
T
S
A
T
V
K
S
L
N
V
L
T
S
--------
I
A
--
I
P
K
-------
V
I
H
S
D
Q
G
A
A
F
T
S
S
T
F
A
E
W
A
K
E
R
G
I
H
L
E
F
S
T
P
Y
H
P
Q
S
S
G
K
-----------
V
E
R
K
H
S
D
I
K
----------------------------------------------------------
11
PsiBlast_PDB
60.80
23%
-39
- C2 -
3L2W
9
POL_FOAMV
A:
[117-231]
-----------------------------------------------------------------------------------------------------------------------------------------
R
P
D
R
------------------------------------
P
Q
K
P
F
D
K
F
F
I
D
Y
I
-
G
P
-
L
P
P
S
Q
G
Y
L
Y
V
---------
L
-
V
V
V
D
G
M
T
G
F
-----
T
W
L
Y
P
T
K
A
---------------------
P
S
T
S
A
T
V
K
S
L
N
V
L
T
S
--------
I
A
--
I
P
K
-------
V
I
H
S
D
Q
G
A
A
F
T
S
S
T
F
A
E
W
A
K
E
R
G
I
H
L
E
F
S
T
P
Y
H
P
Q
S
S
G
K
-----------
V
E
R
K
N
S
D
I
K
----------------------------------------------------------
30
HHSearch
60.76
19%
-49
- C2 -
2X78
-
POL_FOAMV
A:
[119-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
P
F
D
K
F
F
I
D
-
Y
I
G
P
-
L
P
P
S
Q
G
Y
L
Y
V
---------
L
-
V
V
V
D
G
M
T
G
F
-----
T
W
L
Y
P
T
K
A
----------------------
P
S
T
S
A
T
--
V
K
S
L
N
V
--------
L
T
S
-
I
A
I
P
R
-----
V
I
H
S
D
Q
G
A
A
F
T
S
S
T
F
A
E
W
A
K
E
R
G
I
H
L
E
F
S
T
-------
S
K
-----------
V
E
R
K
N
S
D
I
K
R
L
L
T
K
L
L
V
---
G
------
R
P
T
K
W
Y
D
L
L
P
V
V
Q
L
--
A
L
N
N
-
T
Y
S
P
V
L
K
-
Y
T
P
H
Q
L
L
F
---
23
HHSearch
60.62
16%
-50
- C2 -
1EX4
-
?
A:
[7-152]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
G
I
W
Q
L
D
-
C
-
T
H
-
L
----
E
G
K
V
I
---------
L
-
V
A
V
H
V
A
S
G
Y
-----
I
E
A
E
V
I
P
A
----------------------
E
T
G
Q
E
T
--
A
Y
F
L
L
K
--------
L
A
G
R
W
P
-
V
K
-----
T
I
H
T
D
N
G
S
N
F
T
G
A
T
V
R
A
A
C
D
W
A
G
I
K
Q
E
D
G
I
P
---
Q
S
Q
G
V
-----------
V
E
S
M
N
K
E
L
K
K
I
I
G
Q
V
R
D
----------
Q
A
E
H
L
K
T
A
V
Q
M
A
V
F
--
I
H
N
K
-
K
R
K
G
G
I
G
G
Y
S
A
G
E
R
I
V
---
8
PsiBlast_PDB
60.32
23%
-32
- C2 -
3L2R
7
POL_FOAMV
A:
[117-231]
-----------------------------------------------------------------------------------------------------------------------------------------
R
P
D
R
------------------------------------
P
Q
K
P
F
D
K
F
F
I
D
Y
I
-
G
P
-
L
P
P
S
Q
G
Y
L
Y
V
---------
L
-
V
V
V
D
G
M
T
G
F
-----
T
W
L
Y
P
T
K
A
---------------------
P
S
T
S
A
T
V
K
S
L
N
V
L
T
S
--------
I
A
--
I
P
K
-------
V
I
H
S
D
Q
G
A
A
F
T
S
S
T
F
A
E
W
A
K
E
R
G
I
H
L
E
F
S
T
P
Y
H
P
Q
S
S
G
K
-----------
V
E
R
K
N
S
D
I
K
----------------------------------------------------------
29
HHSearch
60.25
17%
-52
- C2 -
3L3U
1
POL_HV1N5
A:
[8-153]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
G
I
W
Q
L
D
-
C
-
T
H
-
L
----
E
G
K
V
I
---------
L
-
V
A
V
H
V
A
S
G
Y
-----
I
E
A
E
V
I
P
A
----------------------
E
T
G
Q
E
T
--
A
Y
F
L
L
K
--------
L
A
G
-
R
W
P
V
K
-----
T
V
H
T
D
N
G
S
N
F
T
S
T
T
V
K
A
A
C
D
W
A
G
I
K
Q
E
D
G
I
P
Y
N
P
Q
S
Q
G
V
-----------
I
E
S
M
N
K
E
L
K
K
I
I
G
Q
V
R
----
D
------
Q
A
E
H
L
K
T
A
V
Q
M
A
V
F
--
I
H
N
H
-
K
R
K
G
G
I
G
G
Y
S
A
G
E
R
I
V
D
--
10
PsiBlast_PDB
60.24
23%
-39
- C2 -
3L2V
9
POL_FOAMV
A:
[117-231]
-----------------------------------------------------------------------------------------------------------------------------------------
R
P
D
R
------------------------------------
P
Q
K
P
F
D
K
F
F
I
D
Y
I
-
G
P
-
L
P
P
S
Q
G
Y
L
Y
V
---------
L
-
V
V
V
D
G
M
T
G
F
-----
T
W
L
Y
P
T
K
A
---------------------
P
S
T
S
A
T
V
K
S
L
N
V
L
T
S
--------
I
A
--
I
P
K
-------
V
I
H
S
D
Q
G
A
A
F
T
S
S
T
F
A
E
W
A
K
E
R
G
I
H
L
E
F
S
T
P
Y
H
P
Q
S
S
G
K
-----------
V
E
R
K
N
S
D
I
K
----------------------------------------------------------
2
PsiBlast_PDB
60.23
24%
-33
- C2 -
3OYN
8
POL_FOAMV
A:
[117-231]
-----------------------------------------------------------------------------------------------------------------------------------------
R
P
D
R
------------------------------------
P
Q
K
P
F
D
K
F
F
I
D
Y
I
-
G
P
-
L
P
P
S
Q
G
Y
L
Y
V
---------
L
-
V
V
V
D
G
M
T
G
F
-----
T
W
L
Y
P
T
K
A
---------------------
P
S
T
S
A
T
V
K
S
L
N
V
L
T
S
--------
I
A
--
I
P
K
-------
V
I
H
S
D
Q
G
A
A
F
T
S
S
T
F
A
E
W
A
K
E
R
G
I
H
L
E
F
S
T
P
Y
H
P
Q
S
S
G
K
-----------
V
E
R
K
H
S
D
I
K
----------------------------------------------------------
20
PsiBlast_PDB
60.05
23%
-32
- C2 -
3OYE
8
POL_FOAMV
A:
[117-231]
-----------------------------------------------------------------------------------------------------------------------------------------
R
P
D
R
------------------------------------
P
Q
K
P
F
D
K
F
F
I
D
Y
I
-
G
P
-
L
P
P
S
Q
G
Y
L
Y
V
---------
L
-
V
V
V
D
G
M
T
G
F
-----
T
W
L
Y
P
T
K
A
---------------------
P
S
T
S
A
T
V
K
S
L
N
V
L
T
S
--------
I
A
--
I
P
K
-------
V
I
H
S
D
Q
G
A
A
F
T
S
S
T
F
A
E
W
A
K
E
R
G
I
H
L
E
F
S
T
P
Y
H
P
Q
S
S
G
K
-----------
V
E
R
K
N
S
D
I
K
----------------------------------------------------------