@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0619: (2016-03-17 )
MDGEKETSKLLHELKKATNLRQVLDENEAEFKSSEMVTYLKELLAEKKLTKASVIRAARLHETYGYQIFSGVRRPSRDRTIALSFGFKLSGLEASRLLKYTEYPPLYAKNRRDAIIIFALDHGYTLDQTNDSLYDLEEALIETYKEEKPLI
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30.--------.......40.....------...50......-----..60.......-------.70-.-.-......------80---........90.......----.100...----....110.......120-.......130.......140..-------------.....150-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------MDG
E
K
E
T
S
K
L
L
H
E
L
K
K
A
T
N
L
R
Q
V
L
D
E
N
E
A
EFK--------
S
S
E
M
V
T
Y
L
K
E
L
L
A
E------KKL
T
K
A
S
V
I
R
A
-----
A
R
L
H
E
TY
G
Y
Q
I
-------
F
SG-V-R-RPSRD
R
------
T
I
---
A
L
S
FG
F
K
LSGL
E
A
S
R
L
L
----KYTEYPP----LYAKNRR
D
A
I
I
I
F
A
LDH-GYTLDQTN
D
S
L
Y
D
L
E
E
A
L
I
E
T
Y
-------------
K
EEKPLI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
71.64
17%
-60
- C2 -
3OST
5
A:
[9-127]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
P
N
S
V
L
L
K
K
F
S
K
G
K
I
L
E
L
E
I
H
A
K
---
I
P
--------
E
K
R
L
Y
E
G
L
H
K
L
L
E
G
-------------------------
W
K
Q
Y
G
----------
L
K
N
-
L
-
V
-
F
N
I
T
N
M
------
I
I
---
T
G
K
L
V
N
D
S
I
L
F
L
R
S
T
L
F
----
E
I
M
V
L
P
--------
N
G
D
G
R
S
L
I
K
F
N
K
K
T
-
G
-----
S
T
K
T
L
T
K
L
A
T
E
I
Q
I
I
L
-------------
Q
K
E
G
V
L
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
69.16
19%
-41
- C4 -
4DOX
-
CAPSD_PMV
A:
[11-174]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
F
P
A
I
T
Q
E
Q
M
S
S
I
K
V
--------
D
P
T
S
N
L
L
P
--------
S
Q
E
Q
L
K
S
V
S
T
L
M
V
A
------
A
K
V
P
A
A
S
V
T
T
V
-----
A
L
E
L
V
N
F
C
Y
D
N
GSSA---
Y
T
T
-
V
-
T
-
G
P
S
S
I
P
------
E
I
S
L
A
Q
L
A
S
I
V
K
A
S
G
T
S
L
R
K
F
C
----
R
Y
--
F
A
P
----
I
I
W
N
L
R
T
D
K
M
A
P
A
N
W
E
A
-
S
G
Y
K
P
S
A
K
F
A
A
F
D
F
F
D
G
V
E
N
P
A
AMQPPSGLTRSPT
Q
E
E
R
I
A
N
A
T
N-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
66.66
21%
-43
- C1 -
4NH0
5
?
A:
[246-1147]
SANMT
L
T
S
L
L
HIDNPYNLD
P
A
V
L
W
RPRPQRNRLRVPIGLDADG
R
P
L
E
L
D
IKESAQGGMGP
H
G
L
C
I
G
A
TGSG
K
S
E
L
L
R
T
L
V
L
A
L
A
M
T
H
SPEV
L
N
F
V
L
V
D
FKGGATFLGMEGLRHVS
A
I
I
T
NLEEELP
L
V
D
R
M
Y
D
A
L
H
G
E
M
V
R
R
Q
E
H
L
R
H
S
GNYAS
L
R
D
Y
E
K
A
R
M
E
G
A
P
L
P
P
M
P
T
L
F
I
V
L
D
E
---------------------
F
S
E
L
L
S
A
------
K
P
D
F
A
E
L
F
V
M
I
-----
G
R
L
G
R
S
L
G
V
H
L
-------
L
L
A
-
S
-
Q
-
R
L
E
E
G
K
LRGLDT
H
L
---
S
Y
R
I
G
L
R
T
F
S
A
M
E
S
R
V
V
LGVP
D
A
Y
E
L
P
P
SPG
N
G
Y
L
K
F
A
T
E
P
L
V
R
F
K
A
A
Y
V
S
G
P
V
D
E
E
S
E
S
L
F
D
V
V
V
R
Q
L
A
G
H
-------------
G
P
E
P
H
Q
I
WLPPLD
V
P
P
T
L
D
E
L
L
PPLSPSAAHGYTADGWEWRGRL
H
A
V
V
GLVDRPFDQ
R
R
D
P
YWLDLSGGAG
H
V
G
V
A
G
G
P
QTG
K
S
T
M
L
R
T
L
I
T
S
L
A
L
L
H
TPQE
V
Q
F
Y
C
LDFGGGTLAGLAELPHVG
S
V
A
T
RLD
A
D
R
I
R
R
T
V
A
E
V
S
A
L
L
E
Q
R
E
Q
E
F
T
E
R
GIDS
M
A
T
Y
R
R
L
R
A
T
GEYAGDGF
G
D
V
F
L
V
V
DN
W
L
T
L
R
Q
DY
E
A
L
E
D
S
I
T
Q
L
A
A
R
GLGYG
I
H
V
V
L
S
S
NKWSEFR
T
S
I
R
D
L
LG
T
K
L
E
L
RLGDPYESEVD
R
K
K
A
A
N
VPENRPG
R
G
L
T
RDG
Y
H
F
L
T
A
L
PRIDGDTSAET
L
T
E
G
I
A
T
T
V
K
T
I
R
E
A
W
HGPTAPPVRMLPNVLPAAQLPSAAESGTRIPIGIDEDSL
S
P
V
Y
L
D
FNTDP
H
F
L
V
F
G
D
T
ECG
K
S
N
L
L
R
L
I
T
A
G
I
I
E
R
Y
TPQQ
A
R
L
I
F
IDYSRSLLDVATTEHQIGYAAS
S
T
A
A
S
S
L
V
R
D
I
K
G
A
M
E
A
R
LPPPDLT
P
E
Q
L
R
S
RSW
W
T
G
A
E
L
F
L
V
V
D
DYEMVATSDNPLRPLAELLPQARDIG
L
H
L
I
I
A
R
S
MGGAGRALYE
P
I
I
Q
R
I
K
E
M
A
S
P
G
L
V
M
S
GNKDEGILLGN
V
K
P
H
KLPQG
R
G
Y
F
V
E
RRS
G
T
R
L
I
Q
T
A
Y
R
E
S
38
HHSearch
65.82
28%
-67
- C2 -
3QWG
-
ESPR_MYCTU
A:
[4-75]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
F
A
A
R
L
N
R
L
F
D
T
VYPPGR
G
P
H
T
S
A
E
V
I
A
A
L
K
A
E
G
I
T
M
S
A
P
Y
L
S
Q
L
-------
R
S
G
-
N
R
T
-
N
P
S
G
A
T
------
M
A
---
A
L
A
N
F
F
R
I
K
A
A
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
64.58
18%
-65
* C2 *
2B5A
1
?
A:
[8-68]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
K
F
G
R
T
L
K
K
I
R
T
Q
------
K
G
V
S
Q
E
E
L
A
D
L
-----
A
G
L
H
R
T
Y
I
S
E
V
-------
E
R
G
-
D
-
R
-
N
I
S
L
I
N
------
I
H
---
K
I
C
A
A
L
D
I
P
A
S
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
63.04
18%
-11
- C3 -
4CLC
-
YBY7_YEAST
A:
[2-170]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
D
K
K
L
L
E
R
L
T
S
R
K
V
P
L
E
E
L
E
D
M
E
K
R
C
F
LSTFT
Y
Q
D
A
F
D
L
G
T
Y
I
R
N
A
V
K
E
------
N
F
P
E
K
P
V
A
I
D
I
-----
S
L
P
N
G
H
C
L
F
R
T
V
TYGGSA
L
D
N
-
D
-
F
-
W
I
Q
R
K
K
------
K
T
---
A
L
R
F
G
H
--
S
S
F
Y
M
G
C
K
K
----
G
D
K
T
P
E
E
----
K
F
F
V
D
S
K
E
----
Y
A
F
H
G
-
G
A
V
L
I
Q
S
E
R
S
D
Y
P
Y
A
C
L
T
I
S
G
L
-------------
K
Q
E
E
D
H
L
M
A
L
S
S
L
I
A
F
A
N
E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
62.25
17%
-82
- C2 -
1B0N
1
SINR_BACSU
A:
[2-66]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
R
I
K
Q
Y
R
K
E
------
K
G
Y
S
L
S
E
L
A
E
K
-----
A
G
V
A
K
S
Y
L
S
S
I
-------
E
R
N
L
Q
-
T
-
N
P
S
I
Q
F
------
L
E
---
K
V
S
A
V
L
D
V
S
V
H
T
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
62.01
15%
-58
- C2 -
1ADR
-
RPC2_BPP22
A:
[4-64]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
M
G
E
R
I
R
A
R
R
K
K
------
L
K
I
R
Q
A
A
L
G
K
M
-----
V
G
V
S
N
V
A
I
S
Q
W
-------
E
R
S
-
E
-
T
-
E
P
N
G
E
N
------
L
L
---
A
L
S
K
A
L
Q
C
S
P
D
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
60.68
21%
-68
- C2 -
3OP9
1
?
A:
[7-70]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
Q
F
A
E
N
L
S
R
L
K
K
E
------
H
G
L
K
N
H
Q
I
A
E
L
-----
L
N
V
Q
T
R
T
V
A
Y
Y
-------
M
S
G
-
E
-
T
-
K
P
D
I
E
K
------
L
I
---
R
L
A
T
Y
F
H
L
S
I
D
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
58.32
16%
-67
- C2 -
3QQ6
-
SINR_BACSU
A:
[-1-60]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
G
Q
R
I
K
Q
Y
R
K
E
------
K
G
Y
S
L
S
E
L
A
E
K
-----
A
G
V
A
K
S
Y
L
S
S
I
-------
E
R
N
L
Q
-
T
-
N
P
S
I
Q
F
------
L
E
---
K
V
S
A
V
L
D
V
S
V
H
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
57.35
18%
-62
- C2 -
3OMT
-
?
A:
[7-67]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
I
F
N
R
L
K
S
V
L
A
E
------
K
G
K
T
N
L
W
L
T
E
T
-----
L
D
K
N
K
T
T
V
S
K
W
-------
C
T
N
-
D
-
V
-
Q
P
S
L
E
T
------
L
F
---
D
I
A
E
A
L
N
V
D
V
R
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
57.29
19%
-49
- C2 -
3IVP
-
?
A:
[9-71]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------
F
R
A
L
G
L
A
I
K
E
A
R
K
K
------
Q
G
L
T
R
E
Q
V
G
A
M
-----
I
E
I
D
P
R
Y
L
T
N
I
-------
E
N
K
-
G
-
Q
-
H
P
S
L
Q
V
------
L
Y
---
D
L
V
S
L
L
N
V
S
V
D
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
57.17
15%
-54
- C2 -
3F52
2
?
A:
[22-87]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
L
L
--------
R
E
A
L
G
A
A
L
R
S
F
R
A
D
------
K
G
V
T
L
R
E
L
A
E
A
-----
S
R
V
S
P
G
Y
L
S
E
L
-------
E
R
G
-
R
-
K
-
E
V
S
S
E
L
------
L
A
---
S
V
C
H
A
L
G
A
S
V
A
D
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
56.82
17%
-68
- C2 -
3U3W
3
?
A:
[4-63]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
G
S
E
I
K
K
I
R
V
L
------
R
G
L
T
Q
K
Q
L
S
E
N
-----
I
-
C
H
Q
S
E
V
S
R
I
-------
E
S
G
-
A
-
V
-
Y
P
S
M
D
I
------
L
Q
---
G
I
A
A
K
L
Q
I
P
I
I
H
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
56.52
22%
-61
- C2 -
3B7H
-
?
A:
[6-66]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
V
S
E
H
L
M
E
L
I
T
Q
------
Q
N
L
T
I
N
R
V
A
T
L
-----
A
G
L
N
Q
S
T
V
N
A
M
-------
F
E
G
-
R
-
S
K
R
P
T
I
T
T
------
I
R
---
K
V
C
G
T
L
G
I
S
V
H
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
56.26
27%
-38
- C2 -
3H44
-
IDE_HUMAN
A:
[780-852]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
F
A
Q
--------
I
I
S
E
P
A
F
N
T
-----
L
R
T
K
E
Q
L
G
Y
I
V
-------
F
S
G
-
P
-
R
-
R
-----------------------
A
N
G
I
Q
G
L
R
F
I
----
I
Q
S
E
K
P
P
----
H
Y
L
E
S
R
V
E
A
F
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
56.21
19%
-37
* C4 *
4BWZ
2
?
A:
[3-386]
-------G
A
E
H
L
L
E
I
F
Y
L
L
L
A
A
Q
V
C
A
F
I
F
K
R
L
NQP
V
V
I
G
E
V
L
A
G
V
L
V
GPALLGLVHEG
E
I
L
E
F
L
A
E
L
G
A
V
F
L
L
F
M
V
G
L
E
TR
L
K
D
I
L
A
V
G
K
E
A
F
L
V
A
V
L
G
V
A
L
P
F
L
G
G
Y
L
Y
G
L
E
I
GFE
T
L
P
A
L
F
L
G
T
A
L
V
ATSV
G
I
T
A
R
V
L
Q
E
L
GVLSR
P
Y
S
R
I
I
L
G
A
A
V
I
D
D
V
L
--
G
L
I
V
L
A
C
V
N
G
V
A
E
T
G
Q
V
E
V
G
--------
A
I
T
R
L
I
V
L
S
V
V
F
V
G
------
L
A
V
F
L
S
T
L
I
A
R
-----
L
P
L
E
R
L
--------------------
P
V
G
S
P
L
------
G
F
---
A
L
A
L
G
V
G
M
A
A
L
A
A
S
I
G
L
-----------------------
A
P
I
V
G
A
F
L
G
-
G
M
L
L
S
E
V
R
-
E
K
Y
R
L
E
E
P
I
F
A
I
E
-------------
S
F
L
A
P
I
F
F
A
M
V
G
V
R
LELSALASP
V
V
L
V
A
G
T
V
V
T
V
I
A
I
L
G
K
V
L
G
G
F
L
G
A
LTQG
V
R
S
A
L
T
V
G
C
G
M
APRG
E
V
G
L
I
V
A
A
L
G
L
K
A
GAVN
E
E
E
Y
A
I
V
L
F
M
V
V
F
T
T
L
F
A
P
F
A
L
K
P
L
I
A
W
T
E
R
E
R
A
A
K
E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
55.48
14%
-71
- C2 -
3PXP
3
?
A:
[4-79]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
A
F
G
K
L
V
Q
A
L
R
R
E
HRDEKG
R
V
W
T
Q
E
V
L
A
E
R
-----
T
Q
L
P
K
R
T
I
E
R
I
-------
E
N
G
-
S
-
L
A
H
L
D
A
D
I
------
L
L
---
R
L
A
D
A
L
E
L
T
I
G
E
R
R
E
F
F
----
F
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
55.31
27%
-42
- C2 -
2WBY
1
IDE_HUMAN (first)
A:
[780-852]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
F
A
Q
--------
I
I
S
E
P
A
F
N
T
-----
L
R
T
K
E
Q
L
G
Y
I
V
-------
F
S
G
-
P
-
R
-
R
-----------------------
A
N
G
I
Q
G
L
R
F
I
----
I
Q
S
E
K
P
P
----
H
Y
L
E
S
R
V
E
A
F
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
54.70
27%
-39
- C2 -
3E4A
2
IDE_HUMAN
A:
[809-876]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
F
A
Q
--------
I
I
S
E
P
A
F
N
T
-----
L
R
T
K
E
Q
L
G
Y
I
V
-------
F
S
G
-
P
-
R
-
R
-----------------------
A
N
G
I
Q
G
L
R
F
I
----
I
Q
S
E
K
P
P
----
H
Y
L
E
S
R
V
E
A
F
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------