@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1989: (2016-03-30 )
MGKTLFDKLWNRHVIYGKEGEPQLLYVDLHLIHEVTSPQAFEGLRLENRPLRRPDKTFATMDHNVPTEDIFNIQDLVAKKQIEALQTNCAEFGVTLADMGSDRQGIVHMVGPETGLTQPGKVIVCGDSHTATHGAFGAIGFGIGSSEVEHVFATQTIWQQKPKSMGIEINGKLPKGVYAKDIILHLIATYGVAFGTGYAVEYYGETIRNMSMEERMTICNMAIEGGAKMGMMAPDETTFEYVRGREYAPTDMDKAISDWKTLQTDSDAEYDLHIKMDASILEPYVTWGTNPEMGVPFSKAFPEIKDMNYERAYEYMGLKPGQTAEQIELGYVFIGSCTNARLSDLEEAARIVKGNKVKNNIRALVVPGSRQVRNAAESIGLDKIFIEAGFEWREPGCSMCLGMNPDQVPDGVHCASTSNRNFEGRQGKGARTHLVSPAMAAAAAINGHFIDIRKVAVISGGN
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10.....---.--.-.----20-..------......30........40.......---.50-......------..60......----..70..---..------..----..80........--90....-....100.......110.---------......120.......130.......140.......150.......160........170.......180....----..--.190-----........200..-----.....210.......220.......230..-.-....240--....----------...------------------250------...--------------.----....--.260.....-.-..270.......-280........290.......300....-...310-------------.........320---------......----...330...---....340.......350------.------..---.---...360.......370.......380.......390.......400.---..--..-..410------.--.---.--.....-----------.420......--.430..--..--....440.......-450.......460------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
G
K
T
L
F
D
K
L
WNR
H
V
I
Y---G--K-E----GE-
P
Q
------
L
L
Y
V
D
L
H
L
I
H
EVTSP
Q
A
FEGLRLEN---RPL-RRPDK
T
------
F
A
TMDHNV
P
T
----
E
D
I
F
N
I
---
Q
D
------
L
V
----
A
K
K
Q
I
E
A
L
Q
T
N
C
--
A
EFGV
T
-
L
A
DMGSDRQ
G
I
V
H
M
VGPE---------TGLTQP
G
K
V
I
V
CGDSHTATHGAFG
A
I
G
FGIGS
S
E
V
E
H
V
F
A
T
Q
T
I
W
Q
QK-PKSM
G
I
E
INGKLPK
G
V
Y
A
K
D
I
I
L
H
L
----
I
A
--
T
Y
G------VAFGTG
Y
A
V
E
Y
Y
G
-----
E
T
I
RNM
S
M
E
E
R
M
T
I
C
N
M
AIEGGAKMGMMAP-D-E
T
T
F
E
Y
V--RGRE----------YAP------------------
T
--------
D
M
D
--------------
K
----
A
I
S
D
--WKT-LQTDS-D-A
E
Y
D
L
H
I
K
M
D
A
S
-IL-E
P
Y
VTWGTNPEMGV
P
F
S
K
AFPEIKD-M
N
Y
E
---------------
R
A
Y
E
YMGLKP-----------GQ
T
A
E
Q
----
I
E
L
G
Y
V
F
IG---SCTN
A
R
L
S
D
L
E
E
A
A
R
I
V------K------GN---K---VKNN
I
R
A
L
V
VPG
S
R
Q
V
R
N
A
A
E
SIGL
D
K
I
F
IEAGFEWREPGC
S
M
CLGM---
N
P
--
D
Q-VPD--------
G
--
V
---
H
--CASTS-----------NRNFEGRQGK--GAR-
T
H
--LV--
S
P
A
M
A
A
A
A
AIN
G
H
F
-
I
D
I
R
K
V
A
V
ISGGN------------------------------------
21
PsiBlast_CBE
96.98
33%
-72
- C4 -
4NQY
1
LEUC_METJA
B:
[22-441]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
I
V
E
K
I
L
A
K
A
--
S
---
G
--
K
-
K
EVSP
G
D
-
I
V
------
M
A
N
I
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
G
I--
E
K
V
-
W
N
P
E
K
I
------
V
I
L
F
D
-------------------
N
------
H
I
----
L
M
R
K
F
V
K
E
Q
G
I
K
--
Y
F
Y
D
I
---------
R
E
G
V
C
H
Q
V
L
P
E
---------
K
G
H
V
A
P
G
E
V
V
V
G
A
D
S
H
T
C
T
H
G
A
F
G
A
F
A
T
G
I
G
S
T
D
M
A
H
V
F
A
T
G
K
L
W
F
K
V
-
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
V
T
S
K
D
V
I
L
S
I
----
I
G
--
E
V
G
------
V
D
G
A
T
Y
K
A
C
Q
F
G
G
-----
E
T
V
K
K
M
S
I
A
S
R
M
T
M
T
N
M
A
I
E
M
G
G
K
T
G
I
I
E
P
-
D
-
E
K
T
I
Q
Y
V
--
K
----------------------------------
E
--------
A
M
K
--------------
K
----
H
G
T
E
RP
F
E
V
-
I
K
G
D
E
-
D
-
A
E
F
A
E
V
Y
E
I
E
A
D
-
K
I
-
E
P
V
F
A
C
P
H
N
V
D
----------------
N
V
K
---------------
Q
A
R
E
V
A
G
-
K
P
-----------------------
I
D
Q
V
F
I
G
---
S
C
T
N
G
R
L
E
D
L
R
M
A
I
K
I
I
E-----
K
------
H
G
---
G
---
I
A
D
D
V
R
V
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
S
---
L
Y
--
G
V
-
L
G
P
--------
G
--
E
---
V
--
C
V
S
T
S
-----------
N
R
N
F
R
G
R
Q
G
S
L-
E
A
E
-
I
Y
--
L
A
--
S
P
I
T
A
A
A
C
A
V
K
G
E
L
-
V
D
P
R
---------------------------------------------
2
PsiBlast_PDB
96.52
33%
-71
- C4 -
4NQY
1
LEUC_METJA
A:
[22-441]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
I
V
E
K
I
L
A
K
A
--
S
---
G
--
K
-
K
EVSP
G
D
-
I
V
------
M
A
N
I
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
G
I--
E
K
V
-
W
N
P
E
K
I
------
V
I
L
F
D
-------------------
N
------
H
I
----
L
M
R
K
F
V
K
E
Q
G
I
K
--
Y
F
Y
D
I
---------
R
E
G
V
C
H
Q
V
L
P
E
---------
K
G
H
V
A
P
G
E
V
V
V
G
A
D
S
H
T
C
T
H
G
A
F
G
A
F
A
T
G
I
G
S
T
D
M
A
H
V
F
A
T
G
K
L
W
F
K
V
-
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
V
T
S
K
D
V
I
L
S
I
----
I
G
--
E
V
G
------
V
D
G
A
T
Y
K
A
C
Q
F
G
G
-----
E
T
V
K
K
M
S
I
A
S
R
M
T
M
T
N
M
A
I
E
M
G
G
K
T
G
I
I
E
P
-
D
-
E
K
T
I
Q
Y
V
--
K
----------------------------------
E
--------
A
M
K
--------------
K
----
H
G
T
E
R
P
F
E
V
-
I
K
G
D
E
-
D
-
A
E
F
A
E
V
Y
E
I
E
A
D
-
K
I
-
E
P
V
F
A
C
P
H
N
V
D
----------------
N
V
K
---------------
Q
A
R
E
V
A
G
-
K
P
-----------------------
I
D
Q
V
F
I
G
---
S
C
T
N
G
R
L
E
D
L
R
M
A
I
K
I
I
E
-----
K
------
H
G
---
G
---
I
A
D
D
V
R
V
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
S
---
L
Y
--
G
V
-
L
G
P
--------
G
--
E
---
V
--
C
V
S
T
S
-----------
N
R
N
F
R
G
R
Q
G
S
L-
E
A
E
-
I
Y
--
L
A
--
S
P
I
T
A
A
A
C
A
V
K
G
E
L
-
V
D
P
R
---------------------------------------------
1
PsiBlast_PDB
95.60
34%
-66
- C4 -
4KP2
-
HACA_METJA
A:
[23-438]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
V
E
K
I
L
S
K
K
V
G
Y
---
E
--
V
C
A
----
G
D
-
S
I
------
E
V
E
V
D
L
A
M
T
H
D
G
T
T
P
L
A
Y
K
A
L
K
E
M
S
---
D
S
V
-
W
N
P
D
K
I
------
V
V
A
F
D
H
N
V
P
P
----
N
T
V
--------------
K
A
----
A
E
M
Q
K
L
A
L
E
F
-
V
--
K
R
F
G
I
K
-
N
F
H
K
G
G
--
E
G
I
C
H
Q
I
L
A
E
---------
N
-
Y
V
L
P
N
M
F
V
A
G
G
D
S
H
T
C
T
H
G
A
F
G
A
F
A
T
G
F
G
A
T
D
M
A
Y
I
Y
A
T
G
E
T
W
I
K
V
-
P
K
T
I
R
V
D
I
V
G
K
-
N
E
N
V
S
A
K
D
I
V
L
R
V
----
C
K
--
E
I
G
------
R
R
G
A
T
Y
M
A
I
E
Y
G
G
-----
E
V
V
K
N
M
D
M
D
G
R
L
T
L
C
N
M
A
I
E
M
G
G
K
T
G
V
I
E
A
-
D
-
E
I
T
Y
D
Y
L
--
K
-
K
E
----------
R
G
L
------------------
S
--------
D
E
D
--------------
I
----
A
K
L
K
--
K
E
R
-
I
T
V
N
R
-
D
E
A
N
Y
Y
K
E
I
E
I
D
I
T
-
D
M
-
E
E
Q
V
A
V
P
H
H
P
D
----------------------------------------
N
V
K
P
-----------
I
S
D
V
E
G
----
T
E
I
N
Q
V
F
I
G
---
S
C
T
N
G
R
L
S
D
L
R
E
A
A
K
Y
L
------
K
------
G
R
---
E
---
V
H
K
D
V
K
L
I
V
I
P
A
S
K
K
V
F
L
Q
A
L
K
E
G
I
I
D
I
F
V
K
A
G
A
M
I
C
T
P
G
C
G
P
C
L
G
A
---
H
Q
--
G
V
-
L
A
E
--------
G
--
E
---
I
--
C
L
S
T
T
-----------
N
R
N
F
K
G
R
M
G
H
I-
N
S
Y
-
I
Y
--
L
A
--
S
P
K
I
A
A
I
S
A
V
K
G
Y
I
-
T
N
-----------------------------------------------
3
PsiBlast_PDB
95.37
34%
-83
- C4 -
4KP1
6
LEUC_METJA
A:
[50-443]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
G
I--
E
K
V
-
W
N
P
E
K
I
------
V
I
L
F
D
H
Q
V
P
A
----
D
S
I
K
A
A
---
E
N
------
H
I
----
L
M
R
K
F
------
V
--
K
E
Q
G
I
K
Y
F
Y
D
I
---
R
E
G
V
C
H
Q
V
L
P
E
---------
K
G
H
V
A
P
G
E
V
V
V
G
A
D
S
H
T
C
T
H
G
A
F
G
A
F
A
T
G
I
G
S
T
D
M
A
H
V
F
A
T
G
K
L
W
F
K
V
-
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
V
T
S
K
D
V
I
L
S
I
----
I
G
--
E
V
G
------
V
D
G
A
T
Y
K
A
C
Q
F
G
G
-----
E
T
V
K
K
M
S
I
A
S
R
M
T
M
T
N
M
A
I
E
M
G
G
K
T
G
I
I
E
P
-
D
-
E
K
T
I
Q
Y
V
--
K
--------------
E
A
------------------
M
--------
K
K
H
--------------
G
----
T
E
R
P
--
F
E
V
-
I
K
G
D
E
-
D
-
A
E
F
A
E
V
Y
E
I
E
A
D
-
K
I
-
E
P
V
F
A
C
P
H
N
V
D
----------------
N
V
K
---------------
Q
A
R
E
V
A
G
-
K
P
-----------------------
I
D
Q
V
F
I
G
---
S
C
T
N
G
R
L
E
D
L
R
M
A
I
K
I
I
E
-----
K
------
H
G
---
G
---
I
A
D
D
V
R
V
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
S
---
L
Y
--
G
V
-
L
G
P
--------
G
--
E
---
V
--
C
V
S
T
S
-----------
N
R
N
F
R
G
R
Q
G
S
L-
E
A
E
-
I
Y
--
L
A
--
S
P
I
T
A
A
A
C
A
V
K
G
E
L
-
V
D
P
R
---------------------------------------------
33
HHSearch
91.08
25%
-60
* C4 *
1C96
3
ACON_BOVIN
A:
[33-482]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
L
T
L
S
E
K
I
V
Y
G
H
L
D
D
PAN
Q
E
I
E
-
R
----
G
K
T
Y
L
------
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
L--
P
K
V
-
A
V
P
S
T
I
--------
H
C
D
H
L
I
E
A
----
Q
L
G
G
E
K
---
D
L
------
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
--
A
K
Y
G
V
G
-
F
W
R
P
---
G
S
G
I
I
H
Q
I
I
L
E
---------
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
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T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
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P
W
E
L
K
C
-
P
K
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I
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V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
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V
----
A
G
--
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L
T
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V
K
G
G
T
G
A
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-----
P
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K
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K
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G
----------
R
A
D
------------------
I
---------
A
N
--------------
L
----
A
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--
K
D
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-
L
V
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D
P
-
G
-
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H
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-
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L
-
K
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P
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L
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V
A
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V
G
S
V
A
E
K
-
E
------------------------------------------
G
W
P
----
L
D
I
R
V
G
L
I
G
---
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
Q
A
L
A
H
-
G
L
---
K
---
C
--
K
S
Q
F
T
I
T
P
G
S
E
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A
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R
D
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Y
A
Q
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L
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G
G
I
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L
A
N
A
C
G
P
C
I
G
Q
---
W
D
RK
D
I
K
K
G
E
--------
K
--
N
---
T
--
I
V
T
S
Y
-----------
N
R
N
F
T
G
R
N
D
A
NP
E
T
H
-
A
F
--
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
T
L
-
K
F
N
P
E
--------------------------------------------
24
Fugue
90.99
25%
-71
- C4 -
1C96
3
ACON_BOVIN
A:
[33-479]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
L
T
L
S
E
K
I
V
Y
G
H
L
D
D
---
P
--
A
-
N
----
Q
E
-
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GKTYL
R
L
R
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A
M
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A
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L
Q
F
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G
---
L
P
K
-
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A
V
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S
------
T
I
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C
D
H
L
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A
Q
LGG
E
K
D
L
R
R
---
A
K
------
D
I
----
N
Q
E
V
Y
N
F
L
A
T
A
G
--
A
K
Y
G
V
G
-
F
W
R
P
G
S
---
G
I
I
H
Q
I
I
L
E
---------
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
-
P
K
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I
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V
K
L
T
G
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L
S
G
W
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S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
VK------
G
G
T
G
A
I
V
E
Y
H
G
-----
P
G
V
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S
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M
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H
R
M
K
K
Y
L
--
S
K
T
--------------------------------------------GR
A
D
I
A
N
L
A
D
E
F
KD
H
--------------
L
V
P
D
P
-
G
-
C
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Y
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Q
V
I
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I
N
L
S
-
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P
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L
A
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V
A
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K
-
E
G
W
P
---------------
L
-------------------------------
D
I
R
V
G
L
I
G
---
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
------
Q
A
L
A
H
G
---
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
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L
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D
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G
G
I
V
L
A
N
A
C
G
P
C
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G
Q
---
W
D
R-
K
D
-
I
K
K
--------
G
E
K
N
---
T
--
I
V
T
S
Y
-----------
N
R
N
F
T
G
R
N
D
A
NP
E
T
H
-
A
F
--
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
T
L
-
K
F
-----------------------------------------------
23
Fugue
90.50
25%
-68
- C4 -
1ACO
2
?
?:
[2-528]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAKVAMSHFEPH
E
Y
I
R
Y
D
L
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
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L
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E
K
I
V
Y
G
H
L
D
D
---
P
--
A
-
N
----
Q
E
-
I
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G
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Y
L
R
L
R
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R
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A
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A
M
L
Q
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---
L
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--
K
V
A
V
P
S
------
T
I
H
C
D
H
L
I
E
A
Q
LGG
E
K
D
L
R
R
---
A
K
------
D
I
----
N
Q
E
V
Y
N
F
L
A
T
A
G
--
A
K
Y
G
V
G
-
F
W
R
P
G
S
---
G
I
I
H
Q
I
I
L
E
---------
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
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L
G
G
I
C
I
G
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G
G
A
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A
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K
L
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G
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L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
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G
--
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L
T
------
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K
G
G
T
G
A
I
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Y
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-----
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A
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L
--
S
K
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----------
R
-
A
------------------
D
--------
I
A
N
--------------
L
----
A
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E
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--
K
D
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-
L
V
P
D
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-
G
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L
A
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P
V
A
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V
G
S
V
A
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K
-
E
G
W
P
----------------------------------------------
L
D
I
R
V
G
L
I
G
---
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
------
Q
A
---
L
A
H
G
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
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D
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Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
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A
C
G
P
C
I
G
Q
WDR
K
D
--
I
K
-
K
G
E
--------
K
--
N
---
T
--
I
V
T
S
Y
-----------
N
R
N
F
T
G
R
N
D
A
--
N
P
E
-
T
H
--
A
F
V
T
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P
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T
A
L
A
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A
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L
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F
L
T
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K
D
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K
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K
L
E
A
P
D
A
D
ELPRAEFDPGQDT
Y
Q
H
P
PKDSSG
Q
R
35
HHSearch
88.29
25%
-69
- C4 -
1L5J
2
ACNB_ECOLI
A:
[380-829]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
F
S
L
A
Q
K
M
V
G
R
A
C
G
V
---
K
GI
R
-
P
----
G
A
-
Y
C
------
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K
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T
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A
---
C
L
G
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L
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------
M
Q
S
F
C
H
T
A
A
Y
----
P
K
P
---------------
V
----
D
V
N
T
H
H
T
L
P
D
F
I
M
-
N
R
G
G
V
--
S
L
R
P
---
G
D
G
V
I
H
S
W
L
N
R
-----------
M
L
L
P
D
T
V
G
T
G
G
D
S
H
T
R
F
P
I
G
---
I
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A
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G
L
V
A
F
A
A
A
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G
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M
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L
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M
-
P
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V
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F
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L
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D
L
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H
A
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L
Y
A
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VEKKGK
K
N
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F
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G
R
I
L
E
I
E
-------
G
L
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C
T
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L
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K
E
P
I
I
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Y
L
--
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S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
------------------
R
R
T
L
E
R
R
I
Q
G
M
E
--------------
K
----
W
L
A
N
--
P
E
L
-
L
E
A
D
A
-
D
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A
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A
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L
A
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K
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I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
V
---------------------------------------------------
Q
G
----
E
K
I
D
E
V
F
I
G
---
S
C
M
T
-
N
I
G
H
F
R
A
A
G
K
L
L
------
D
------
A
H
---
K
---
G
Q
L
P
T
R
L
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
N
---
Q
---
A
R
-
V
A
D
--------
G
--
A
---
T
--
V
V
S
T
S
-----------
T
R
N
F
P
N
R
L
G
T
--
G
A
N
-
V
F
--
L
A
--
S
A
E
L
A
A
V
A
A
L
I
G
K
L
-
P
T
P
E
E
Y
Q
T
Y
----------------------------------------
25
Fugue
87.17
23%
-59
- C4 -
1L5J
2
ACNB_ECOLI
A:
[1-862]
M
L
E
E
Y
R
K
H
V
A
E
R
A
A
E
GIAPKPLD
A
N
Q
M
A
A
L
V
E
L
L
K
N
PPAGE
E
E
F
L
L
D
L
L
T
NRVPPGVD
E
A
A
Y
V
K
A
G
F
L
A
A
I
A
K
GEAKSPLLT
P
E
K
A
I
E
L
L
G
T
MQGG
Y
N
I
H
P
L
I
D
A
L
DDAKL
A
P
I
A
A
K
A
L
S
H
TLLMFDN
F
Y
D
V
E
E
K
A
K
A
GN
E
Y
A
K
Q
V
M
Q
S
W
A
D
A
E
W
F
L
N
RPALAE
K
L
T
V
T
V
FKVTGETNTDDLSPAPDAWSRPD
I
P
L
H
A
L
A
MLKNAREGIEPDQPGVVGP
I
K
Q
I
E
A
L
Q
Q
KG
F
P
L
A
Y
V
G
DVVGTGSSRK
S
A
T
N
S
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L
W
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D
D
I
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K
R
G
G
G
L
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P
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F
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L
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D
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E
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N
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A
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L
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R
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F
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R
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L
A
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M
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A
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---
K
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R
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----
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A
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C
------
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V
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D
T
T
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A
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A
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------
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Q
S
F
C
H
T
A
A
Y
-------------
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K
------
P
V
----
D
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N
T
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H
T
L
P
D
F
I
--
M
N
R
G
G
V
-
S
L
R
P
G
---
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G
V
I
H
S
W
L
N
R
---------
M
--
L
L
P
D
T
V
G
T
G
G
D
S
H
T
R
F
P
I
G
I
S
F
---
P
A
G
S
G
L
V
A
F
A
A
A
T
G
V
M
P
L
D
M
-
P
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V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
----
P
L
--
Y
A
I
K
Q
GLL-
T
V
E
K
K
G
K
K
N
I
F
S
G
R
I
L
E
I
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G
L
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L
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A
F
E
L
T
D
A
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A
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S
A
A
G
C
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L
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E
P
I
I
E
Y
L
--
N
S
N
I
----------
V
L
L
K
W
M
I
A
E
GYGD
R
R
T
L
E
R
R
I
Q
--------
G
M
E
--------------
K
----
W
L
A
N
--
P
E
L
-
L
E
A
D
A
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A
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A
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L
A
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K
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A
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D
P
D
----------------------------------------
D
A
R
P
-----------
L
S
A
V
Q
G
----
E
K
I
D
E
V
F
I
G
---
S
C
M
T
-
N
I
G
H
F
R
A
A
G
K
L
L
------
D
------
A
H
---
K
---
G
Q
L
P
T
R
L
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
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C
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L
C
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G
N
---
Q
A
---
R
-
V
A
D
--------
G
--
A
---
T
--
V
V
S
T
S
-----------
T
R
N
F
P
N
R
L
G
T
--
G
A
N
-
V
F
--
L
A
--
S
A
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L
A
A
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L
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P
T
P
E
E
Y
Q
T
Y
V
A
Q
V
D
K
T
AVDTYRYLNFNQL
S
Q
Y
T
E
K
A
D
G
VIFQ-------
34
HHSearch
85.79
23%
-58
- C4 -
2B3Y
4
ACOC_HUMAN
A:
[72-569]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
-
E
V
------
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
NPV
C
P
A
D
L
V
I
D
H
S
I
Q
V
----
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
----
N
R
E
R
F
E
F
L
K
-
W
G
S
Q
A
F
H
N
M
R
-
I
I
P
---
P
G
S
G
I
I
H
Q
V
N
L
E
YLARVVFDQ
D
G
Y
Y
Y
P
D
-
S
L
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
-
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
----
T
K
--
H
L
R
------
Q
V
G
V
V
G
K
F
V
E
F
F
G
-----
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
-
D
-
E
V
S
I
T
Y
L
--
V
Q
T
G
----------
R
D
E
------------------
E
K
L
K
Y
I
K
--
K
Y
L
--------------
Q
----
A
V
G
M
--
F
R
D
F
N
D
P
S
Q
-
D
-
P
D
F
T
Q
V
V
E
L
D
L
K
-
T
V
-
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
-
C
L
G
A
KQGFKGFQVAPEHHN
D
H
K
T
F
I
Y
D
N
T
-----------
E
F
T
L
A
H
----
G
S
V
V
I
A
A
I
T
---
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
------
A
K
K
A
V
D
A
G
L
---
N
---
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
---
S
---
G
P
-
L
P
E
P
V
V
E
A
I
T
Q
G
--
D
LV
A
V
--
G
V
L
S
G
-----------
N
R
N
F
E
G
R
V
H
P
N-
T
R
A
-
N
Y
--
L
A
--
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
-
R
I
D
F
---------------------------------------------
20
PsiBlast_PDB
83.66
25%
-61
- C4 -
2B3Y
3
ACOC_HUMAN
A:
[200-571]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
-
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
----
T
K
--
H
L
R
------
Q
V
G
V
V
G
K
F
V
E
F
F
G
-----
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
-
D
-
E
V
S
I
T
Y
L
V
Q
T
G
R
D
----------
E
E
K
------------------
L
--------
K
Y
I
--------------
K
K
Y
L
Q
A
V
G
M
--
F
R
D
-
F
N
D
P
S
Q
D
-
P
D
F
T
Q
V
V
E
L
D
L
K
-
T
V
-
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
---------------
Q
G
F
K
G
F
Q
V
A
P
EHHN
D
H
K
T
F
I
Y
D
N
T
E
F
T
----
L
A
H
G
S
V
V
I
A
AIT
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
------
G
L
---
N
---
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
----
N
S
--
G
P
-
L
P
E
--------
P
--
V
---
V
--
E
A
I
T
Q
G
DLV
A
V
G
V
L
SG
N
R
N
F
E
G
R
V
H
P
--
N
T
R
A
N
Y
--
L
A
--
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
--------------------------------------------
19
PsiBlast_PDB
83.48
25%
-65
- C4 -
2B3X
3
ACOC_HUMAN
A:
[200-571]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
-
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
----
T
K
--
H
L
R
------
Q
V
G
V
V
G
K
F
V
E
F
F
G
-----
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
-
D
-
E
V
S
I
T
Y
L
V
Q
T
G
R
D
----------
E
E
K
------------------
L
--------
K
Y
I
--------------
K
K
Y
L
Q
A
V
G
M
--
F
R
D
-
F
N
D
P
S
Q
D
-
P
D
F
T
Q
V
V
E
L
D
L
K
-
T
V
-
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
---------------
Q
G
F
K
G
F
Q
V
A
P
EHHN
D
H
K
T
F
I
Y
D
N
T
E
F
T
----
L
A
H
G
S
V
V
I
A
AIT
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
------
G
L
---
N
---
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
----
N
S
--
G
P
-
L
P
E
--------
P
--
V
---
V
--
E
A
I
T
Q
G
DLV
A
V
G
V
L
SG
N
R
N
F
E
G
R
V
H
P
--
N
T
R
A
N
Y
--
L
A
--
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
--------------------------------------------
4
PsiBlast_PDB
81.83
28%
-73
- C4 -
1NIS
2
ACON_BOVIN
A:
[127-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
T
A
G
--
A
K
Y
G
V
G
-
F
W
R
P
G
S
---
G
I
I
H
Q
I
I
L
E
---------
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
-
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
T
G
A
I
V
E
Y
H
G
-----
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
-
N
-
H
R
M
K
K
Y
L
--
S
K
T
G
----------
R
A
----------------------------
D
I
A
--------------
N
----
L
A
D
E
--
F
K
D
H
L
V
P
D
S
-
G
-
C
H
Y
D
Q
L
I
E
I
N
L
S
-
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
-----------------------------------------------
G
S
V
A
E
K
E
GWP
L
D
I
R
V
G
L
I
G
---
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
Q
A
L
---
A
H
---
G
---
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W--
D
R
--
K
D
-
I
K
K
--------
G
--
E
---
K
N
T
I
V
T
S
Y
-----------
N
R
N
F
T
G
R
N
D
A
--
N
P
E
-
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
8
PsiBlast_PDB
81.65
28%
-72
- C4 -
8ACN
2
ACON_BOVIN
A:
[127-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
T
A
G
--
A
K
Y
G
V
G
-
F
W
R
P
G
S
---
G
I
I
H
Q
I
I
L
E
---------
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
-
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
T
G
A
I
V
E
Y
H
G
-----
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
-
N
-
H
R
M
K
K
Y
L
--
S
K
T
G
----------
R
A
----------------------------
D
I
A
--------------
N
----
L
A
D
E
--
F
K
D
H
L
V
P
D
S
-
G
-
C
H
Y
D
Q
L
I
E
I
N
L
S
-
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
-----------------------------------------------
G
S
V
A
E
K
E
GWP
L
D
I
R
V
G
L
I
G
---
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
Q
A
L
---
A
H
---
G
---
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W--
D
R
--
K
D
-
I
K
K
--------
G
--
E
---
K
N
T
I
V
T
S
Y
-----------
N
R
N
F
T
G
R
N
D
A
--
N
P
E
-
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
16
PsiBlast_PDB
81.64
27%
-74
- C4 -
1B0J
2
ACON_PIG
A:
[127-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
T
A
G
--
A
K
Y
G
V
G
-
F
W
R
P
G
S
---
G
I
I
H
Q
I
I
L
E
---------
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
-
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
T
G
A
I
V
E
Y
H
G
-----
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
-
N
-
H
R
M
K
K
Y
L
--
S
K
T
G
----------
R
A
----------------------------
D
I
A
--------------
N
----
L
A
D
E
--
F
K
D
H
L
V
P
D
P
-
G
-
C
H
Y
D
Q
V
I
E
I
N
L
S
-
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
-----------------------------------------------
G
S
V
A
E
K
E
GWP
L
D
I
R
V
G
L
I
G
---
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
Q
A
L
---
A
H
---
G
---
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W--
D
R
--
K
D
-
I
K
K
--------
G
--
E
---
K
N
T
I
V
T
S
Y
-----------
N
R
N
F
T
G
R
N
D
A
--
N
P
E
-
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
5
PsiBlast_PDB
81.32
28%
-73
- C4 -
1NIT
2
ACON_BOVIN
A:
[127-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
T
A
G
--
A
K
Y
G
V
G
-
F
W
R
P
G
S
---
G
I
I
H
Q
I
I
L
E
---------
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
-
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
T
G
A
I
V
E
Y
H
G
-----
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
-
N
-
H
R
M
K
K
Y
L
--
S
K
T
G
----------
R
A
----------------------------
D
I
A
--------------
N
----
L
A
D
E
--
F
K
D
H
L
V
P
D
S
-
G
-
C
H
Y
D
Q
L
I
E
I
N
L
S
-
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
-----------------------------------------------
G
S
V
A
E
K
E
GWP
L
D
I
R
V
G
L
I
G
---
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
Q
A
L
---
A
H
---
G
---
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W--
D
R
--
K
D
-
I
K
K
--------
G
--
E
---
K
N
T
I
V
T
S
Y
-----------
N
R
N
F
T
G
R
N
D
A
--
N
P
E
-
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
10
PsiBlast_PDB
81.20
28%
-76
- C4 -
1AMJ
2
ACON_BOVIN
A:
[127-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
T
A
G
--
A
K
Y
G
V
G
-
F
W
R
P
G
S
---
G
I
I
H
Q
I
I
L
E
---------
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
-
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
T
G
A
I
V
E
Y
H
G
-----
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
-
N
-
H
R
M
K
K
Y
L
--
S
K
T
G
----------
R
A
----------------------------
D
I
A
--------------
N
----
L
A
D
E
--
F
K
D
H
L
V
P
D
S
-
G
-
C
H
Y
D
Q
L
I
E
I
N
L
S
-
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
-----------------------------------------------
G
S
V
A
E
K
E
GWP
L
D
I
R
V
G
L
I
G
---
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
Q
A
L
---
A
H
---
G
---
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W--
D
R
--
K
D
-
I
K
K
--------
G
--
E
---
K
N
T
I
V
T
S
Y
-----------
N
R
N
F
T
G
R
N
D
A
--
N
P
E
-
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
6
PsiBlast_PDB
81.15
28%
-72
- C4 -
1ACO
2
ACON_BOVIN
A:
[127-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
T
A
G
--
A
K
Y
G
V
G
-
F
W
R
P
G
S
---
G
I
I
H
Q
I
I
L
E
---------
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
-
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
T
G
A
I
V
E
Y
H
G
-----
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
-
N
-
H
R
M
K
K
Y
L
--
S
K
T
G
----------
R
A
----------------------------
D
I
A
--------------
N
----
L
A
D
E
--
F
K
D
H
L
V
P
D
S
-
G
-
C
H
Y
D
Q
L
I
E
I
N
L
S
-
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
-----------------------------------------------
G
S
V
A
E
K
E
GWP
L
D
I
R
V
G
L
I
G
---
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
Q
A
L
---
A
H
---
G
---
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W--
D
R
--
K
D
-
I
K
K
--------
G
--
E
---
K
N
T
I
V
T
S
Y
-----------
N
R
N
F
T
G
R
N
D
A
--
N
P
E
-
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
11
PsiBlast_PDB
81.09
27%
-71
- C4 -
1C96
3
ACON_BOVIN
A:
[126-475]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
T
A
G
--
A
K
Y
G
V
G
-
F
W
R
P
G
S
---
G
I
I
H
Q
I
I
L
E
---------
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
-
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
T
G
A
I
V
E
Y
H
G
-----
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
-
N
-
H
R
M
K
K
Y
L
--
S
K
T
G
----------
R
A
----------------------------
D
I
A
--------------
N
----
L
A
D
E
--
F
K
D
H
L
V
P
D
P
-
G
-
C
H
Y
D
Q
V
I
E
I
N
L
S
-
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
-----------------------------------------------
G
S
V
A
E
K
E
GWP
L
D
I
R
V
G
L
I
G
---
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
Q
A
L
---
A
H
---
G
---
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W--
D
R
--
K
D
-
I
K
K
--------
G
--
E
---
K
N
T
I
V
T
S
Y
-----------
N
R
N
F
T
G
R
N
D
A
--
N
P
E
-
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
17
PsiBlast_PDB
81.03
27%
-76
- C4 -
1C97
3
ACON_BOVIN
A:
[126-475]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
T
A
G
--
A
K
Y
G
V
G
-
F
W
R
P
G
S
---
G
I
I
H
Q
I
I
L
E
---------
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
-
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
T
G
A
I
V
E
Y
H
G
-----
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
-
N
-
H
R
M
K
K
Y
L
--
S
K
T
G
----------
R
A
----------------------------
D
I
A
--------------
N
----
L
A
D
E
--
F
K
D
H
L
V
P
D
P
-
G
-
C
H
Y
D
Q
V
I
E
I
N
L
S
-
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
-----------------------------------------------
G
S
V
A
E
K
E
GWP
L
D
I
R
V
G
L
I
G
---
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
Q
A
L
---
A
H
---
G
---
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W--
D
R
--
K
D
-
I
K
K
--------
G
--
E
---
K
N
T
I
V
T
S
Y
-----------
N
R
N
F
T
G
R
N
D
A
--
N
P
E
-
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------