@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2336: (2016-04-02 )
MIYTITLNPSIDYIVQIDQLNLGGLNRMKQDYKLPGGKGINVSRVLNQLNVPSLATGFLGGFTGSFIKDWLQNEGVKTGFVTVKDDTRINIKLKHGEETEINGLGPAISEKEINEFLKVMDKVTANDIVILSGSVPPSLGNDFYNKIIQICKEKKAEFMIDTTGQELLDALPNRPILIKPNHHELADLFGVKLGSVEELIPYGKKCLELGAQHVIVSMAGDGALLFTGEDVYFADALKGELKNSVGAGDSMIAGFVGTFDKTRDPVKAFAAGVATGGATAFSTDLAQKELIDELLPQVKITKITGRN
Atome Classification :
(20 SA)
.........10.......-.20.......---.30...---.....40........50........60.-.......70.--...--....80..-......90..---.---.---.-...100.....---..110--..----..-.----.---...120-..-....-...130.......140.......150.......160....---...170--.--.-...-...180--....-.....190----...-.-.-...200.......210........220.......230....-...240..--.....250.......260........270.......280..--.....290.......300.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
Y
T
I
TLNPSI
D
Y
I
V
Q
I
D-QLNLG
G
L
N
R
M
---
K
Q
D
YKL---PGGKGI
N
V
S
R
V
L
N
QLNV
P
S
L
A
T
G
F
LGG
F
-
T
G
S
F
I
K
D
W
L
Q--NEG--VKT
G
F
V
T
V-KDD
T
R
I
N
I
K
L
---K---H---G-EETEINGLGPA---I
S
E
----
K
E
----
I
N
-
E
----
F
---
L
K
V
M
---
D
K
-VTAN-
D
I
V
I
L
SGSVPPSL
G
N
D
F
Y
N
K
I
I
Q
I
C
K
EKKA
E
F
M
I
DTT
G
Q
E
---
L
L
D
AL---P--N-R
P
I
-
L
I
KP----N
H
H
E
-
L
A
D
L
F
G
V-----KLG-
S
-
V
-
E
E
L
I
P
Y
G
K
K
C
L
E
LG-A
Q
H
V
I
V
S
MAGD
G
A
L
L
F
TGE
D
V
Y
F
A
D
A
-
L
K
G
E
L
K
NS--VGA
G
D
S
M
I
A
G
F
VGTFD-KTR
D
P
V
K
A
F
A
A
GVATGGATAF
S
T
D
--
L
A
Q
K
E
L
I
D
E
L
LPQ
V
K
I
T
K
ITGRN
2
PsiBlast_PDB
97.51
44%
-94
- C1 -
2JG5
-
?
A:
[1-306]
M
I
Y
T
V
T
F
N
P
S
I
D
Y
V
I
F
T
N
-
D
F
K
I
D
G
L
N
R
A
---
T
A
T
Y
K
F
---
A
G
G
K
G
I
N
V
S
R
V
L
K
T
L
D
V
E
S
T
A
L
G
F
A
G
G
F
-
P
G
K
F
I
I
D
T
L
N
--
N
S
A
--
I
Q
S
N
F
I
E
V
-
D
E
D
T
R
I
N
V
K
L
---
K
---
T
---
G
-
Q
E
T
E
I
N
A
P
G
P
H
---
I
T
S
----
T
Q
----
F
E
-
Q
----
L
---
L
Q
Q
I
---
K
N
-
T
T
S
E
-
D
I
V
I
V
A
G
S
V
P
S
S
I
P
S
D
A
Y
A
Q
I
A
Q
I
T
A
Q
T
G
A
K
L
V
V
D
A
E
K
E
L
---
A
E
S
V
L
---
P
--
Y
-
H
P
L
-
F
I
K
P
----
N
K
D
E
-
L
E
V
M
F
N
T
-----
T
V
N
-
S
-
D
-
A
D
V
I
K
Y
G
R
L
L
V
D
K
G
-
A
Q
S
V
I
V
S
L
G
G
D
G
A
I
Y
I
D
K
E
I
S
I
K
A
V
N
-
P
Q
G
K
V
V
N
T
--
V
G
S
G
D
S
T
V
A
G
M
V
A
G
I
A
-
S
G
L
S
I
E
K
A
F
Q
Q
A
V
A
C
G
T
A
T
A
F
D
E
D
--
L
A
T
R
D
A
I
E
K
I
K
S
Q
V
T
I
S
V
L
D
G
E
-
37
HHSearch
97.25
44%
-95
- C1 -
2JG5
-
?
A:
[1-305]
M
I
Y
T
V
T
F
N
P
S
I
D
Y
V
I
F
T
N
-
D
F
K
I
D
G
L
N
R
A
---
T
A
T
Y
K
F
---
A
G
G
K
G
I
N
V
S
R
V
L
K
T
L
D
V
E
S
T
A
L
G
F
A
G
G
F
-
P
G
K
F
I
I
D
T
L
N
--
N
S
A
--
I
Q
S
N
F
I
E
V
-
D
E
D
T
R
I
N
V
K
L
---
K
---
T
---
G
-
Q
E
T
E
I
N
A
P
G
P
H
---
I
T
S
----
T
Q
----
F
E
-
Q
----
L
---
L
Q
Q
I
K
N
T
T
S
----
E
-
D
I
V
I
V
A
G
S
V
P
S
S
I
P
S
D
A
Y
A
Q
I
A
Q
I
T
A
Q
T
G
A
K
L
V
V
D
A
E
K
E
L
---
A
E
S
V
L
------
P
Y
H
P
L
-
F
I
K
P
----
N
K
D
E
-
L
E
V
M
F
N
T
-----
T
V
N
-
S
-
D
-
A
D
V
I
K
Y
G
R
L
L
V
D
K
G
-
A
Q
S
V
I
V
S
L
G
G
D
G
A
I
Y
I
D
K
E
I
S
I
K
A
V
N
-
P
Q
G
K
V
V
N
T
--
V
G
S
G
D
S
T
V
A
G
M
V
A
G
I
A
-
S
G
L
S
I
E
K
A
F
Q
Q
A
V
A
C
G
T
A
T
A
F
D
E
D
--
L
A
T
R
D
A
I
E
K
I
K
S
Q
V
T
I
S
V
L
D
G
--
42
HHSearch
95.54
43%
-87
- C1 -
2ABQ
3
?
A:
[1-300]
M
I
Y
T
V
T
L
N
P
S
I
D
Y
I
V
Q
V
E
-
N
F
Q
Q
G
V
V
N
R
S
---
E
R
D
R
K
Q
---
P
G
G
K
G
I
N
V
S
R
V
L
K
R
L
G
H
E
T
K
A
L
G
F
L
G
G
F
-
T
G
A
Y
V
R
N
A
L
E
--
K
E
E
--
I
G
L
S
F
I
E
V
-
E
G
D
T
R
I
N
V
K
I
---
K
---
G
---
K
-
Q
E
T
E
L
N
G
T
A
P
L
---
I
K
K
----
E
H
----
V
Q
-
A
----
L
L
E
Q
L
T
E
L
---
E
K
----
G
-
D
V
L
V
L
A
G
S
V
P
Q
A
M
P
Q
T
I
Y
R
S
M
T
Q
I
A
K
E
R
G
A
F
V
A
V
D
T
S
G
E
A
---
L
H
E
V
L
---
A
--
A
-
K
P
S
-
F
I
K
P
----
N
H
H
E
-
L
S
E
L
V
S
K
-----
P
I
A
-
S
-
I
-
E
D
A
I
P
H
V
Q
R
L
I
G
E
G
-
I
E
S
I
L
V
S
F
A
G
D
G
A
L
F
A
S
A
E
G
M
F
H
V
N
V
-
P
S
G
E
V
R
N
S
--
V
G
A
G
D
S
V
V
A
G
F
L
A
A
L
Q
-
E
G
K
S
L
E
D
A
V
P
F
A
V
A
A
G
S
A
T
A
F
S
D
G
--
F
C
T
R
E
E
V
E
R
L
Q
Q
Q
L
Q
R
-------
1
PsiBlast_PDB
95.46
42%
-86
- C1 -
2ABQ
3
?
A:
[2-301]
-
I
Y
T
V
T
L
N
P
S
I
D
Y
I
V
Q
V
E
-
N
F
Q
Q
G
V
V
N
R
S
---
E
R
D
R
K
Q
---
P
G
G
K
G
I
N
V
S
R
V
L
K
R
L
G
H
E
T
K
A
L
G
F
L
G
G
F
-
T
G
A
Y
V
R
N
A
L
E
--
K
E
E
--
I
G
L
S
F
I
E
V
-
E
G
D
T
R
I
N
V
K
I
---
K
---
G
---
K
-
Q
E
T
E
L
N
G
T
A
P
L
---
I
K
K
----
E
H
----
V
Q
-
A
----
L
---
L
E
Q
L
---
T
E
-
L
E
K
G
-
D
V
L
V
L
A
G
S
V
P
Q
A
M
P
Q
T
I
Y
R
S
M
T
Q
I
A
K
E
R
G
A
F
V
A
V
D
T
S
G
E
A
---
L
H
E
V
L
---
A
--
A
-
K
P
S
-
F
I
K
P
----
N
H
H
E
-
L
S
E
L
V
S
K
-----
P
I
A
-
S
-
I
-
E
D
A
I
P
H
V
Q
R
L
I
G
E
G
-
I
E
S
I
L
V
S
F
A
G
D
G
A
L
F
A
S
A
E
G
M
F
H
V
N
V
-
P
S
G
E
V
R
N
S
--
V
G
A
G
D
S
V
V
A
G
F
L
A
A
L
Q
-
E
G
K
S
L
E
D
A
V
P
F
A
V
A
A
G
S
A
T
A
F
S
D
G
--
F
C
T
R
E
E
V
E
R
L
Q
Q
Q
L
Q
R
T
------
41
HHSearch
89.58
34%
-84
- C1 -
2F02
1
LACC_ENTFA
A:
[3-313]
L
I
V
T
V
T
M
N
P
S
I
D
I
S
Y
L
L
D
-
H
L
K
L
D
T
V
N
R
T
---
S
Q
V
T
K
T
---
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
-
H
G
A
F
I
A
N
E
L
K
--
K
A
N
--
I
P
Q
A
F
T
S
I
-
K
E
E
T
R
D
S
I
A
I
---
L
---
H
E--
G
-
N
Q
T
E
I
L
E
A
G
P
T
---
V
S
P
----
E
E
----
I
S
-
N
F
L
E
N
F
---
D
Q
L
I
---
K
Q
----
A
-
E
I
V
T
I
S
G
S
L
A
K
G
L
P
S
D
F
Y
Q
E
L
V
Q
K
A
H
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
---
L
R
Q
V
L
---
Q
GP
W
-
K
P
Y
-
L
I
K
P
----
N
L
E
E
-
L
E
G
L
L
G
Q
-----
D
F
S
-
E
N
P
L
A
A
V
Q
T
A
L
T
K
P
M
F
A
G
-
I
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
-
P
T
I
Q
A
K
N
P
--
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
-
K
D
A
P
A
A
E
L
L
K
W
G
M
A
A
G
M
A
N
A
Q
E
R
M
TG
H
V
D
V
E
N
V
K
K
H
L
M
N
I
Q
V
V
E
I
----
38
HHSearch
86.70
33%
-82
* C1 *
2JG1
2
LACC_STAA8
A:
[21-330]
M
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
-
A
L
K
L
D
D
V
N
R
V
---
Q
E
V
S
K
T
---
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
--
H
A
D
--
I
K
H
A
F
Y
N
I
-
K
G
E
T
R
N
C
I
A
I
---
L
---
H
E--
G
-
Q
Q
T
E
I
L
E
Q
G
P
E
---
I
D
N
Q
E
A
A
G
F
----
I
K
-
H
----
F
---
E
Q
M
M
---
E
K
----
V
-
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
L
Q
T
V
L
E
N
P
------
Y
-
K
P
T
-
V
I
K
P
----
N
I
S
E
-
L
Y
Q
L
L
N
Q
-----
P
L
D
-
E
S
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
-
P
T
I
S
V
L
N
P
--
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
-
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
TG
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
----
5
PsiBlast_PDB
84.00
37%
-90
- C1 -
2JGV
-
LACC_STAA8
A:
[22-280]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
-
A
L
K
L
D
D
V
N
R
V
---
Q
E
V
S
K
T
---
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
--
H
A
D
--
I
K
H
A
F
Y
N
I
-
K
G
E
T
R
N
C
I
A
I
---
L
---
H
E--
G
-
Q
Q
T
E
I
L
E
Q
G
P
E
---
I
D
N
----
Q
E
A
A
G
F
I
K
-
H
----
F
---
E
Q
L
L
---
E
K
-
V
E
A
----
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
E
N-
P
--
Y
-
K
P
T
-
V
I
K
P
----
N
I
S
E
-
L
Y
Q
L
L
N
Q
-----
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
-
P
T
I
S
V
L
N
P
--
V
G
S
G
D
S
T
V
A
G
I
-------------------------------------------------------
6
PsiBlast_PDB
83.00
37%
-93
- C1 -
2Q5R
-
LACC_STAAC
A:
[2-260]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
-
A
L
K
L
D
D
V
N
R
V
---
Q
E
V
S
K
T
---
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
--
H
A
D
--
I
K
H
A
F
Y
N
I
-
K
G
E
T
R
N
C
I
A
I
---
L
---
H
E--
G
-
Q
Q
T
E
I
L
E
Q
G
P
E
---
I
D
N
----
Q
E
A
A
G
F
I
K
-
H
----
F
---
E
Q
L
L
---
E
K
-
V
E
A
----
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
E
N-
P
--
Y
-
K
P
T
-
V
I
K
P
----
N
I
S
E
-
L
Y
Q
L
L
N
Q
-----
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
-
P
T
I
S
V
L
N
P
--
V
G
S
G
D
S
T
V
A
G
I
-------------------------------------------------------
22
PsiBlast_CBE
82.94
37%
-89
- C1 -
2JGV
1
LACC_STAA8
B:
[22-280]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
-
A
L
K
L
D
D
V
N
R
V
---
Q
E
V
S
K
T
---
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
--
H
A
D
--
I
K
H
A
F
Y
N
I
-
K
G
E
T
R
N
C
I
A
I
---
L
---
H
E--
G
-
Q
Q
T
E
I
L
E
Q
G
P
E
---
I
D
N
----
Q
E
A
A
G
F
I
K
-
H
----
F
---
E
Q
L
L
---
E
K
-
V
E
A
----
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
E
N-
P
--
Y
-
K
P
T
-
V
I
K
P
----
N
I
S
E
-
L
Y
Q
L
L
N
Q
-----
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
-
P
T
I
S
V
L
N
P
--
V
G
S
G
D
S
T
V
A
G
I
-------------------------------------------------------
4
PsiBlast_PDB
82.59
37%
-89
- C1 -
2F02
1
LACC_ENTFA
A:
[3-263]
L
I
V
T
V
T
M
N
P
S
I
D
I
S
Y
L
L
D
-
H
L
K
L
D
T
V
N
R
T
---
S
Q
V
T
K
T
---
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
-
H
G
A
F
I
A
N
E
L
K
--
K
A
N
--
I
P
Q
A
F
T
S
I
-
K
E
E
T
R
D
S
I
A
I
---
L
---
H
E--
G
-
N
Q
T
E
I
L
E
A
G
P
T
---
V
S
P
----
E
E
----
I
S
-
N
----
F
---
L
E
N
F
---
D
Q
L
I
K
Q
A
-
E
I
V
T
I
S
G
S
L
A
K
G
L
P
S
D
F
Y
Q
E
L
V
Q
K
A
H
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
---
L
R
Q
V
L
Q
G-
P
--
W
-
K
P
Y
-
L
I
K
P
----
N
L
E
E
-
L
E
G
L
L
G
Q
D
F
S
E
N
P
L
A
-
A
-
V
-
Q
T
A
L
---
T
K
P
M
F
A
G
-
I
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
-
P
T
I
Q
A
K
N
P
--
V
G
S
G
D
A
T
I
A
G
L
-------------------------------------------------------
7
PsiBlast_PDB
82.12
37%
-88
- C1 -
2JG1
2
LACC_STAA8
A:
[22-280]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
-
A
L
K
L
D
D
V
N
R
V
---
Q
E
V
S
K
T
---
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
--
H
A
D
--
I
K
H
A
F
Y
N
I
-
K
G
E
T
R
N
C
I
A
I
---
L
---
H
E--
G
-
Q
Q
T
E
I
L
E
Q
G
P
E
---
I
D
N
----
Q
E
----
A
A
-
G
----
F
---
I
K
H
F
---
E
Q
-
M
M
E
K
V
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
E
N-
P
--
Y
-
K
P
T
-
V
I
K
P
----
N
I
S
E
-
L
Y
Q
L
L
N
Q
-----
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
-
P
T
I
S
V
L
N
P
--
V
G
S
G
D
S
T
V
A
G
I
-------------------------------------------------------
3
PsiBlast_PDB
82.06
37%
-85
- C1 -
2AWD
6
LACC_ENTFA
A:
[3-263]
L
I
V
T
V
T
M
N
P
S
I
D
I
S
Y
L
L
D
-
H
L
K
L
D
T
V
N
R
T
---
S
Q
V
T
K
T
---
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
-
H
G
A
F
I
A
N
E
L
K
--
K
A
N
--
I
P
Q
A
F
T
S
I
-
K
E
E
T
R
D
S
I
A
I
---
L
---
H
E--
G
-
N
Q
T
E
I
L
E
A
G
P
T
---
V
S
P
----
E
E
----
I
S
-
N
----
F
---
L
E
N
F
---
D
Q
L
I
K
Q
A
-
E
I
V
T
I
S
G
S
L
A
K
G
L
P
S
D
F
Y
Q
E
L
V
Q
K
A
H
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
---
L
R
Q
V
L
Q
G
-
P
--
W
-
K
P
Y
-
L
I
K
P
----
N
L
E
E
-
L
E
G
L
L
G
Q
D
F
S
EN
P
L
A
-
A
-
V
-
Q
T
A
L
---
T
K
P
M
F
A
G
-
I
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
-
P
T
I
Q
A
K
N
P
--
V
G
S
G
D
A
T
I
A
G
L
-------------------------------------------------------
21
PsiBlast_CBE
81.98
37%
-86
- C1 -
2JGV
1
LACC_STAA8
D:
[22-280]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
-
A
L
K
L
D
D
V
N
R
V
---
Q
E
V
S
K
T
---
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
--
H
A
D
--
I
K
H
A
F
Y
N
I
-
K
G
E
T
R
N
C
I
A
I
---
L
---
H
E--
G
-
Q
Q
T
E
I
L
E
Q
G
P
E
---
I
D
N
----
Q
E
AAGF
I
K
-
H
----
F
---
E
Q
L
L
---
E
K
-
V
E
A
----
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
EN-
P
--
Y
-
K
P
T
-
V
I
K
P
----
N
I
S
E
-
L
Y
Q
L
L
N
Q
-----
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
-
P
T
I
S
V
L
N
P
--
V
G
S
G
D
S
T
V
A
G
I
-------------------------------------------------------
8
PsiBlast_PDB
79.80
32%
-105
- C1 -
2AJR
2
?
A:
[14-285]
-
V
L
T
V
T
L
N
P
A
L
D
R
E
I
F
I
E
-
D
F
Q
V
N
R
L
Y
R
I
---
N
D
L
S
K
T
Q
M
S
P
G
G
K
G
I
N
V
S
I
A
L
S
K
L
G
V
P
S
V
A
T
G
F
V
G
G
Y
-
M
G
K
I
L
V
E
E
L
R
K
I
S
K
L
--
I
T
T
N
F
V
Y
V
-
E
G
E
T
R
E
N
I
E
I
I
D
E
K
---
N
---
K
-
T
I
T
A
I
N
F
P
G
P
D
---
V
T
D
----
M
D
----
V
N
-
H
----
F
---
L
R
R
Y
---
K
M
-
T
L
S
K
V
D
C
V
V
I
S
G
S
I
P
P
G
V
N
E
G
I
C
N
E
L
V
R
L
A
R
E
R
G
V
F
V
F
V
E
Q
T
P
R
----
L
L
E
R
I
Y
E
G
P
--
E
-
F
P
N
-
V
V
K
P
DLRG
N
H
----
A
S
F
L
G
V
-----
D
L
K
-
T
-
F
-
D
D
Y
V
K
L
A
E
K
L
A
E
-
K
-
S
Q
V
S
V
V
S
Y
E
V
K
N
D
I
V
A
T
R
E
G
V
W
L
I
R
S
--
K
E
E
I
D
T
S
HL
L
G
A
G
D
A
Y
V
A
G
M
V
Y
Y
F
I
-
K
------------------------------------------------
11
PsiBlast_PDB
79.68
28%
-81
- C1 -
3N1C
2
PFKB_ECOLI
A:
[4-288]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
-
Q
I
Y
P
E
G
K
L
R
C
---
T
A
P
V
F
E
---
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
--
D
E
N
--
V
P
V
A
T
V
E
A
-
K
D
W
T
R
Q
N
L
H
V
---
H
V
EA
S
---
G
-
E
Q
Y
R
F
V
M
P
G
A
A
---
L
N
E
----
D
E
----
F
R
-
Q
----
L
---
E
E
Q
V
---
L
E
-
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
---
A
--
I
-
G
N
I
E
L
V
K
P
----
N
Q
K
E
-
L
S
A
L
V
N
R
-----
E
L
T
-
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
-
P
P
V
K
S
Q
S
T
--
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
-
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
----------------------------
43
HHSearch
78.88
28%
-83
- C1 -
2AJR
2
?
A:
[13-330]
M
V
L
T
V
T
L
N
P
A
L
D
R
E
I
F
I
E
-
D
F
Q
V
N
R
L
Y
R
I
NDL
S
K
T
Q
M
S
---
P
G
G
K
G
I
N
V
S
I
A
L
S
K
L
G
V
P
S
V
A
T
G
F
V
G
G
Y
-
M
G
K
I
L
V
E
E
L
R
--
K
I
S
KL
I
T
T
N
F
V
Y
V
-
E
G
E
T
R
E
N
I
E
I
---
I
---
D
EK-
N
K
T
I
T
A
I
N
F
P
G
P
D
VT
D
M
D
V
----
N
H
----
F
L
-
R
R
---
Y
---
K
M
T
L
---
S
K
----
V
-
D
C
V
V
I
S
G
S
I
P
P
G
V
N
E
G
I
C
N
E
L
V
R
L
A
R
E
R
G
V
F
V
F
V
E
Q
T
P
R
L
L
E
R
I
Y
E
G
P
------
E
-
F
P
N
-
V
V
K
P
----
D
L
R
G
N
H
A
S
F
L
G
V
-----
D
L
K
-
T
-
F
-
D
D
Y
V
K
L
A
E
K
L
A
E
K
S
--
Q
V
S
V
V
S
Y
E
V
K
N
D
I
V
A
T
R
E
G
V
W
L
I
R
S
K
E
E
I
D
T
S
H
L
--
L
G
A
G
D
A
Y
V
A
G
M
V
Y
Y
F
I
K
H
G
A
N
F
L
E
M
A
K
F
G
F
A
S
A
L
A
A
T
R
R
K
E
K
Y
M
P
D
L
E
A
I
K
K
E
Y
D
H
F
T
V
E
R
V
----
12
PsiBlast_PDB
78.74
28%
-78
- C1 -
3UMO
7
PFKB_ECOLI
A:
[4-288]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
-
Q
I
Y
P
E
G
K
L
R
C
---
T
A
P
V
F
E
---
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
--
D
E
N
--
V
P
V
A
T
V
E
A
-
K
D
W
T
R
Q
N
L
H
V
---
H
V
EA
S
---
G
-
E
Q
Y
R
F
V
M
P
G
A
A
---
L
N
E
----
D
E
----
F
R
-
Q
----
L
---
E
E
Q
V
---
L
E
-
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
---
A
--
I
-
G
N
I
E
L
V
K
P
----
N
Q
K
E
-
L
S
A
L
V
N
R
-----
E
L
T
-
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
-
P
P
V
K
S
Q
S
T
--
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
-
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
----------------------------
10
PsiBlast_PDB
78.65
28%
-79
- C1 -
3CQD
7
PFKB_ECOLI
A:
[4-293]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
-
Q
I
Y
P
E
G
K
L
R
C
---
T
A
P
V
F
E
---
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
--
D
E
N
--
V
P
V
A
T
V
E
A
-
K
D
W
T
R
Q
N
L
H
V
---
H
V
EA
S
---
G
-
E
Q
Y
R
F
V
M
P
G
A
A
---
L
N
E
----
D
E
----
F
R
-
Q
----
L
---
E
E
Q
V
---
L
E
-
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
---
A
--
I
-
G
N
I
E
L
V
K
P
----
N
Q
K
E
-
L
S
A
L
V
N
R
-----
E
L
T
-
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
-
P
P
V
K
S
Q
S
T
--
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
-
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
----------------------------
9
PsiBlast_PDB
78.50
28%
-78
- C1 -
3UQE
4
PFKB_ECOLI
A:
[4-290]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
-
Q
I
D
P
E
G
K
L
R
C
---
T
A
P
V
F
E
---
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
--
D
E
N
--
V
P
V
A
T
V
E
A
-
K
D
W
T
R
Q
N
L
H
V
---
H
V
EA
S
---
G
-
E
Q
Y
R
F
V
M
P
G
A
A
---
L
N
E
----
D
E
----
F
R
-
Q
----
L
---
E
E
Q
V
---
L
E
-
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
---
A
--
I
-
G
N
I
E
L
V
K
P
----
N
Q
K
E
-
L
S
A
L
V
N
R
-----
E
L
T
-
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
-
P
P
V
K
S
Q
S
T
--
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
-
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
----------------------------
40
HHSearch
77.99
25%
-78
- C1 -
3IE7
3
?
A:
[3-310]
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
L
F
I
R
G
E
L
E
K
R
K
T
N
R
V
---
I
K
T
E
F
D
---
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
N
L
-
D
K
L
Y
A
I
L
K
--
E
K
H
--
I
N
H
D
F
L
V
E
A
G
T
S
T
R
E
C
F
V
V
---
L
---
S
DDT
N
-
G
S
T
M
I
P
E
A
G
F
T
---
V
S
Q
T
N
K
-
D
N
----
L
L
K
Q
----
I
---
A
K
K
V
---
K
K
----
E
-
D
M
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
---
E
--
M
-
G
V
D
-
F
I
K
P
----
N
E
D
E
-
V
I
A
I
L
D
E
-----
K
T
N
-
S
-----
L
E
E
N
I
R
T
L
A
E
-
K
-
I
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
K
L
Y
Q
V
I
P
-
P
K
V
Q
E
R
N
D
--
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
-
M
N
M
P
I
T
E
T
L
K
V
A
T
G
C
S
A
S
K
V
M
Q
Q
D
S
S
S
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
E
---