@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0304: (2015-11-30 )
MTKLLFMGTPDFSATVLKGILADGKYDVLAVVTQPDRAVGRKKEIKMTPVKEVALENNIPVYQPEKLSGSPELEQLMTLGADGIVTAAFGQFLPTKLLESVGFAINVHASLLPKYRGGAPIHYAIINGEKEAGVTIMEMVAKMDAGDMVSKASVEITDEDNVGTMFDRLAVVGRDLLLDTLPGYLSGDIKPIPQNEEEVSFSPNISPDEERIDWNKSSRDIFNHVRGMYPWPVAHTLLEGNRFKLYEVTMSEGKGSPGQVIAKTKNSLTVATGDGAIELKSVQPAGKPRMDIKDFLNGVGRNLEIGDKFGE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60..-..-....-----70.-----.......80........90........-100.-......110.......120.......130.......140.......150.......160......-.170........180.......190.......200.......210.......220......-.-230.......240....--.--.-.250.-------------.-------------..-.--....260.......270.-......280.......290.......300.......310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
K
L
L
F
MGTPD
F
S
A
T
V
L
K
G
I
LADGK
Y
D
V
L
A
V
V
TQP
D
R
AVGRKK
E
I
KMTP
V
K
E
V
ALENNIPVYQ-PE-KLSG-----
S
P
E
-----
L
E
Q
L
M
T
LGAD
G
I
V
T
A
A
F
G
Q
F
L
P
T
K
L
L
E
-SVG
F
-
A
I
N
V
H
A
S
LLPKYRGG
A
P
I
H
Y
A
I
INGEKEA
G
V
T
I
M
E
M
V
A
KMDAGDMV
S
K
A
S
V
E
I
TDED
N
V
G
T
M
F
D
R
-
L
A
-
V
V
G
R
D
L
L
L
D
TL
P
G
Y
LSGDIKPIPQNEEEVSFSPNISP
D
E
E
RIDWNKS
S
R
D
I
F
N
H
V
RGM-Y-PW
P
V
A
H
T
LLEGN
R
F
K
L
Y
--
E
--
V
-
T
M--S-------------E-------------GK-G--SPG
Q
V
I
A
KTKN
S
L
T
V
ATG-D
G
A
I
E
L
KSVQPAGKPRM
D
I
K
D
F
L
N
GVGRNLEIGDKFGE
1
PsiBlast_PDB
97.26
46%
-106
- C4 -
4IQF
3
FMT_BACAN
A:
[6-314]
--
K
V
V
F
M
G
T
P
D
F
S
V
P
V
L
R
R
L
I
E
D
G
-
Y
D
V
I
G
V
V
T
Q
P
D
R
P
V
G
R
K
K
V
L
T
P
T
P
V
K
V
E
A
E
K
H
G
I
P
V
L
Q
-
P
L
-
R
I
R
E
-----
K
D
E
-----
Y
E
K
V
L
A
L
E
P
D
L
I
V
T
A
A
F
G
Q
I
V
P
N
E
I
L
E
-
A
P
K
Y
G
C
I
N
V
H
A
S
L
L
P
E
L
R
G
G
A
P
I
H
Y
A
I
M
E
G
K
E
K
T
G
I
T
I
M
Y
M
V
E
K
L
D
A
G
D
I
L
T
Q
V
E
V
E
I
E
E
R
E
T
T
G
S
L
F
D
K
-
L
S
-
E
A
G
A
H
L
L
S
K
T
V
P
L
L
I
Q
G
K
L
E
P
I
K
Q
N
E
E
E
V
T
F
A
Y
N
I
K
R
E
Q
E
K
I
D
W
T
K
T
G
E
E
V
Y
N
H
I
R
G
L
-
N
-
P
W
P
V
A
Y
T
T
L
A
G
Q
V
V
K
V
W
W
G
E
--
K
-
V
P
--
V
-------------
T
-------------
K
S
-
A
--
E
A
G
T
I
V
A
I
E
E
D
G
F
V
V
A
T
G
N
E
T
G
V
K
I
T
E
L
Q
P
S
G
K
K
R
M
S
C
S
Q
F
L
R
G
T
--
K
P
E
I
G
T
K
L
G
-
66
HHSearch
90.66
38%
-107
- C4 -
3TQQ
1
FMT_COXBU
A:
[2-312]
S
L
K
I
V
F
A
G
T
P
Q
F
A
V
P
T
L
R
A
L
I
D
-
S
S
H
R
V
L
A
V
Y
T
Q
P
D
----------
E
S
P
V
K
E
I
A
R
Q
N
E
I
P
I
I
Q
-
P
F
-
S
L
R
D
-----
E
V
E
-----
Q
E
K
L
I
A
M
N
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
K
A
L
N
-
A
F
R
L
G
C
V
N
V
H
A
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
A
I
L
A
G
D
R
E
T
G
I
S
I
M
Q
M
N
E
G
L
D
T
G
D
V
L
A
K
S
A
C
V
I
S
S
E
D
T
A
A
D
L
H
D
R
-
L
S
-
L
I
G
A
D
L
L
L
E
S
L
A
K
L
E
K
G
D
I
K
L
E
K
Q
D
E
A
S
A
T
Y
A
S
K
I
Q
K
Q
E
A
L
I
D
W
R
K
S
A
V
E
I
A
R
Q
V
R
A
F
-
N
-
P
T
P
I
A
F
T
Y
F
E
G
Q
P
M
R
I
W
--
R
--
A
-
T
V
--
V
-------------
D
EK-----------
T
D
-
F
--
E
P
G
V
L
V
D
A
D
K
K
G
I
S
I
A
A
G
-
S
G
I
L
R
L
H
Q
L
Q
L
P
G
K
R
V
C
S
A
G
D
F
I
N
A
H
G
D
K
L
I
P
G
K
T
V
F
G
4
PsiBlast_PDB
90.64
38%
-110
- C4 -
3TQQ
1
FMT_COXBU
A:
[4-306]
--
K
I
V
F
A
G
T
P
Q
F
A
V
P
T
L
R
A
L
I
-
D
S
S
H
R
V
L
A
V
Y
T
Q
P
D
----------
E
S
P
V
K
E
I
A
R
Q
N
E
I
P
I
I
Q
-
P
F
-
S
L
R
D
-----
E
V
E
-----
Q
E
K
L
I
A
M
N
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
K
A
L
N
-
A
F
R
L
G
C
V
N
V
H
A
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
A
I
L
A
G
D
R
E
T
G
I
S
I
M
Q
M
N
E
G
L
D
T
G
D
V
L
A
K
S
A
C
V
I
S
S
E
D
T
A
A
D
L
H
D
R
-
L
S
-
L
I
G
A
D
L
L
L
E
S
L
A
K
L
E
K
G
D
I
K
L
E
K
Q
D
E
A
S
A
T
Y
A
S
K
I
Q
K
Q
E
A
L
I
D
W
R
K
S
A
V
E
I
A
R
Q
V
R
A
F
-
N
-
P
T
P
I
A
F
T
Y
F
E
G
Q
P
M
R
I
W
--
R
--
A
-
T
V
--
V
-------------
D
-------------
E
K
-
T
DF
E
P
G
V
L
V
D
A
D
K
K
G
I
S
I
A
A
G
-
S
G
I
L
R
L
H
Q
L
Q
L
P
G
K
R
V
C
S
A
G
D
F
I
N
A
H
G
D
K
L
I
P
G
K
T
V
F
G
68
HHSearch
90.01
39%
-99
- C4 -
1FMT
-
FMT_ECOLI
A:
[3-313]
S
L
R
I
I
F
A
G
T
P
D
F
A
A
R
H
L
D
A
L
L
S
-
S
G
H
N
V
V
G
V
F
T
Q
P
D
R
P
------
L
M
P
S
P
V
K
V
L
A
E
E
K
G
L
P
V
F
Q
-
P
V
-
S
L
R
P
-----
Q
E
N
-----
Q
Q
L
V
A
E
L
Q
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
A
V
L
E
-
M
P
R
L
G
C
I
N
V
H
G
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
S
L
W
A
G
D
A
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
Y
K
L
S
C
P
I
T
A
E
D
T
S
G
T
L
Y
D
K
-
L
A
-
E
L
G
P
Q
G
L
I
T
T
L
K
Q
L
A
D
G
T
A
K
P
E
V
Q
D
E
T
L
V
T
Y
A
E
K
L
S
K
E
E
A
R
I
D
W
S
L
S
A
A
Q
L
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
W
L
E
I
E
G
Q
P
V
K
V
W
--
K
--
A
-
S
V
--
I
-------------
D
TA-----------
T
N
-
A
--
A
P
G
T
I
L
E
A
N
K
Q
G
I
Q
V
A
T
G
-
D
G
I
L
N
L
L
S
L
Q
P
A
G
K
K
A
M
S
A
Q
D
L
L
N
S
R
R
E
W
F
V
P
G
N
R
L
V
-
67
HHSearch
89.70
36%
-104
- C4 -
3Q0I
3
FMT_VIBCH
A:
[7-318]
S
L
R
I
V
F
A
G
T
P
D
F
A
A
R
H
L
A
A
L
L
S
-
S
E
H
E
I
I
A
V
Y
T
Q
P
E
---------
T
A
S
P
V
K
T
L
A
L
E
H
N
V
P
V
Y
Q
-
P
E
-
N
F
K
S
-----
D
E
S
-----
K
Q
Q
L
A
A
L
N
A
D
L
M
V
V
V
A
Y
G
L
L
L
P
K
V
V
L
D
-
T
P
K
L
G
C
I
N
V
H
G
S
I
L
P
R
W
R
G
A
A
P
I
Q
R
S
I
W
A
G
D
S
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
K
I
A
T
L
P
I
E
A
S
D
T
S
A
S
M
Y
D
K
-
L
A
-
E
L
G
P
Q
A
L
L
E
C
L
Q
D
I
A
Q
G
T
A
V
A
V
K
Q
D
D
G
L
A
N
Y
A
H
K
L
S
K
E
E
A
R
I
N
W
S
D
A
A
T
H
I
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
H
F
E
V
A
E
N
S
I
K
V
W
--
Q
--
A
-
R
V
--
E
-------------
T
RA-----------
V
T
-
Q
--
T
P
G
T
I
I
Q
A
D
K
S
G
I
Y
V
A
T
G
-
Q
D
V
L
V
L
E
S
L
Q
I
P
G
K
K
A
L
P
V
Q
D
I
L
N
A
R
A
D
W
F
S
V
G
S
Q
L
S
-
2
PsiBlast_PDB
89.05
40%
-99
- C4 -
1FMT
-
FMT_ECOLI
A:
[5-301]
--
R
I
I
F
A
G
T
P
D
F
A
A
R
H
L
D
A
L
L
S
S
G
-
H
N
V
V
G
V
F
T
Q
P
D
R
P
------
L
M
P
S
P
V
K
V
L
A
E
E
K
G
L
P
V
F
Q
-
P
V
-
S
L
R
P
-----
Q
E
N
-----
Q
Q
L
V
A
E
L
Q
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
A
V
L
E
-
M
P
R
L
G
C
I
N
V
H
G
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
S
L
W
A
G
D
A
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
Y
K
L
S
C
P
I
T
A
E
D
T
S
G
T
L
Y
D
K
-
L
A
-
E
L
G
P
Q
G
L
I
T
T
L
K
Q
L
A
D
G
T
A
K
P
E
V
Q
D
E
T
L
V
T
Y
A
E
K
L
S
K
E
E
A
R
I
D
W
S
L
S
A
A
Q
L
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
W
L
E
I
E
G
Q
P
V
K
V
W
--
K
--
A
-
S
V
ID
T
-------------
A
-------------
T
N
-
A
--
A
P
G
T
I
L
E
A
N
K
Q
G
I
Q
V
A
T
G
-
D
G
I
L
N
L
L
S
L
Q
P
A
G
K
K
A
M
S
A
Q
D
L
L
N
S
R
R
E
W
F
V
P
G
N
R
L
V
-
5
PsiBlast_PDB
88.61
34%
-103
- C4 -
3Q0I
3
FMT_VIBCH
A:
[9-318]
--
R
I
V
F
A
G
T
P
D
F
A
A
R
H
L
A
A
L
L
S
-
S
E
H
E
I
I
A
V
Y
T
Q
P
E
---------
T
A
S
P
V
K
T
L
A
L
E
H
N
V
P
V
Y
Q
-
P
E
-
N
F
K
S
-----
D
E
S
-----
K
Q
Q
L
A
A
L
N
A
D
L
M
V
V
V
A
Y
G
L
L
L
P
K
V
V
L
D
-
T
P
K
L
G
C
I
N
V
H
G
S
I
L
P
R
W
R
G
A
A
P
I
Q
R
S
I
W
A
G
D
S
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
K
I
A
T
L
P
I
E
A
S
D
T
S
A
S
M
Y
D
K
-
L
A
-
E
L
G
P
Q
A
L
L
E
C
L
Q
D
I
A
Q
G
T
A
V
A
V
K
Q
D
D
G
L
A
N
Y
A
H
K
L
S
K
E
E
A
R
I
N
W
S
D
A
A
T
H
I
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
H
F
E
V
A
E
N
S
I
K
V
W
--
Q
A
R
V
-
E
T
--
R
-------------
A
-------------
V
T
-
Q
--
T
P
G
T
I
I
Q
A
D
K
S
G
I
Y
V
A
T
G
-
Q
D
V
L
V
L
E
S
L
Q
I
P
G
K
K
A
L
P
V
Q
D
I
L
N
A
R
A
D
W
F
S
V
G
S
Q
L
S
-
3
PsiBlast_PDB
87.19
40%
-92
- C4 -
2FMT
1
FMT_ECOLI
A:
[5-301]
--
R
I
I
F
A
G
T
P
D
F
A
A
R
H
L
D
A
L
L
S
S
G
-
H
N
V
V
G
V
F
T
Q
P
D
R
P
A
G
R
G
K
K
L
M
P
S
P
V
K
V
L
A
E
E
K
G
L
P
V
F
Q
-
P
V
-
S
L
R
P
-----
Q
E
N
-----
Q
Q
L
V
A
E
L
Q
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
A
V
L
E
-
M
P
R
L
G
C
I
N
V
H
G
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
S
L
W
A
G
D
A
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
Y
K
L
S
C
P
I
T
A
E
D
T
S
G
T
L
Y
D
K
-
L
A
-
E
L
G
P
Q
G
L
I
T
T
L
K
Q
L
A
D
G
T
A
K
P
E
V
Q
D
E
T
L
V
T
Y
A
E
K
L
S
K
E
E
A
R
I
D
W
S
L
S
A
A
Q
L
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
W
L
E
I
E
G
Q
P
V
K
V
W
--
K
--
A
-
S
V
I
D
T
-------------
A
-------------
T
N
-
A
--
A
P
G
T
I
L
E
A
N
K
Q
G
I
Q
V
A
T
G
-
D
G
I
L
N
L
L
S
L
Q
P
A
G
K
K
A
M
S
A
Q
D
L
L
N
S
R
R
E
W
F
V
P
G
N
R
L
V
-
21
PsiBlast_CBE
87.08
40%
-92
- C4 -
2FMT
1
FMT_ECOLI
B:
[5-301]
--
R
I
I
F
A
G
T
P
D
F
A
A
R
H
L
D
A
L
L
S
S
G
-
H
N
V
V
G
V
F
T
Q
P
D
R
P
A
G
R
G
K
K
L
M
P
S
P
V
K
V
L
A
E
E
K
G
L
P
V
F
Q
-
P
V
-
S
L
R
P
-----
Q
E
N
-----
Q
Q
L
V
A
E
L
Q
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
A
V
L
E
-
M
P
R
L
G
C
I
N
V
H
G
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
S
L
W
A
G
D
A
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
Y
K
L
S
C
P
I
T
A
E
D
T
S
G
T
L
Y
D
K
-
L
A
-
E
L
G
P
Q
G
L
I
T
T
L
K
Q
L
A
D
G
T
A
K
P
E
V
Q
D
E
T
L
V
T
Y
A
E
K
L
S
K
E
E
A
R
I
D
W
S
L
S
A
A
Q
L
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
W
L
E
I
E
G
Q
P
V
K
V
W
--
K
--
A
-
S
V
ID
T
-------------
A
-------------
T
N
-
A
--
A
P
G
T
I
L
E
A
N
K
Q
G
I
Q
V
A
T
G
-
D
G
I
L
N
L
L
S
L
Q
P
A
G
K
K
A
M
S
A
Q
D
L
L
N
S
R
R
E
W
F
V
P
G
N
R
L
V
-
69
HHSearch
85.19
31%
-101
- C4 -
2BLN
3
ARNA_ECOLI
A:
[1-304]
-
M
K
T
V
V
F
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
-
A
G
Y
E
I
S
A
I
F
T
H
T
D
---------
F
Y
G
S
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
-
P
D
-
N
V
N
H
-----
P
L
W
-----
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
-
L
A
P
A
G
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
-
L
C
-
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
A
D
-
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
--
S
--
S
-
R
V
--
H
-------------
P
HA-----------
S
K
-
A
--
Q
P
G
S
V
I
S
V
--
A
P
L
L
I
A
C
G
-
D
G
A
L
E
I
V
T
G
Q
A
G
D
G
I
T
M
Q
G
S
Q
L
A
Q
T
L
G
--
L
V
Q
G
S
R
L
--
6
PsiBlast_PDB
84.31
35%
-100
- C4 -
3R8X
6
FMT_YERPE
A:
[9-305]
--
R
I
I
F
A
G
T
P
D
F
A
A
R
H
L
-
G
A
L
L
S
S
Q
H
K
I
V
G
V
F
T
Q
P
D
R
P
------
L
T
P
S
P
V
K
I
L
A
E
H
H
G
I
P
V
F
Q
-
P
K
-
S
L
R
P
-----
E
E
N
-----
Q
H
L
V
A
D
L
N
A
D
I
M
V
V
V
A
Y
G
L
I
L
P
A
A
V
L
A
-
M
P
R
L
G
C
I
N
V
H
G
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
S
V
W
A
G
D
E
K
T
G
I
T
I
M
Q
M
D
I
G
L
D
T
G
A
M
L
H
K
I
E
C
A
I
Q
P
E
D
T
S
A
T
L
Y
D
K
-
L
A
-
Q
L
G
P
Q
G
L
L
I
T
L
Q
Q
L
A
A
G
T
A
L
A
E
V
Q
N
E
T
Q
A
T
Y
A
E
K
L
S
K
E
E
A
K
L
D
W
T
L
S
A
T
Q
L
E
R
C
I
R
A
F
-
N
-
P
W
P
V
S
Y
F
I
V
D
E
Q
P
I
K
V
W
--
Q
--
A
Q
V
L
--
P
-------------
A
-------------
G
E
D
A
--
E
P
G
T
I
I
H
A
D
K
H
G
I
Q
V
A
T
A
-
D
G
V
L
N
I
T
Q
L
Q
P
A
G
K
K
A
M
S
A
A
D
L
L
N
S
R
R
E
W
F
I
P
G
S
Q
L
--
23
PsiBlast_CBE
82.83
32%
-103
- C4 -
4WKG
1
ARNA_ECOLI
F:
[2-280]
--
K
T
V
V
F
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
A
G
-
Y
E
I
S
A
I
F
T
H
T
D
N
P
-------
F
Y
G
S
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
-
P
D
-
N
V
N
H
-----
P
L
W
-----
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
L
A
P
A
G
-
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
-
L
C
-
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
-
A
D
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
SS
R
--
V
-
H
P
--
H
-------------
A
-------------
S
K
-
A
--
Q
P
G
S
V
I
S
V
A
--
P
L
L
I
A
C
G
-
D
G
A
L
E
I
V
T
G
Q
A
G
D
G
I
T
M
Q
G
S
Q
L
A
Q
T
L
G
L
V
Q
G
S
R
L
R
R
T
R
8
PsiBlast_PDB
82.61
32%
-112
- C4 -
1YRW
-
ARNA_ECOLI
A:
[2-280]
--
K
T
V
V
F
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
A
G
-
Y
E
I
S
A
I
F
T
H
T
D
---------
F
Y
G
S
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
-
P
D
-
N
V
N
H
-----
P
L
W
-----
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
L
A
P
A
G
-
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
-
L
C
-
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
-
A
D
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
S
S
R
--
V
-
H
P
-------------------------------
K
-
A
--
Q
P
G
S
V
I
S
V
A
P
--
L
L
I
A
C
G
-
D
G
A
L
E
I
V
T
G
Q
A
G
D
G
I
T
M
Q
G
S
Q
L
A
Q
T
L
G
L
V
Q
--------
22
PsiBlast_CBE
81.87
32%
-104
- C4 -
2BLN
4
ARNA_ECOLI
B:
[2-280]
--
K
T
V
V
F
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
A
G
-
Y
E
I
S
A
I
F
T
H
T
D
---------
F
Y
G
S
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
-
P
D
-
N
V
N
H
-----
P
L
W
-----
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
L
A
P
A
G
-
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
-
L
C
-
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
-
A
D
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
SS
R
--
V
-
H
P
--
H
-------------
A
-------------
S
K
-
A
--
Q
P
G
S
V
I
S
V
A
P
--
L
L
I
A
C
G
-
D
G
A
L
E
I
V
T
G
Q
A
G
D
G
I
T
M
Q
G
S
Q
L
A
Q
T
L
G
L
V
Q
G
S
R
L
----
7
PsiBlast_PDB
81.65
32%
-103
- C4 -
2BLN
3
ARNA_ECOLI
A:
[2-280]
--
K
T
V
V
F
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
A
G
-
Y
E
I
S
A
I
F
T
H
T
D
---------
F
Y
G
S
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
-
P
D
-
N
V
N
H
-----
P
L
W
-----
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
L
A
P
A
G
-
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
-
L
C
-
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
-
A
D
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
S
S
R
--
V
-
H
P
--
H
-------------
A
-------------
S
K
-
A
--
Q
P
G
S
V
I
S
V
A
P
--
L
L
I
A
C
G
-
D
G
A
L
E
I
V
T
G
Q
A
G
D
G
I
T
M
Q
G
S
Q
L
A
Q
T
L
G
L
V
Q
G
S
R
L
----
9
PsiBlast_PDB
81.55
32%
-100
- C4 -
1Z7E
-
ARNA_ECOLI
A:
[2-280]
--
K
T
V
V
F
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
A
G
-
Y
E
I
S
A
I
F
T
H
T
D
-----------
G
S
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
-
P
D
-
N
V
N
H
-----
P
L
W
-----
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
L
A
P
A
G
-
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
-
L
C
-
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
-
A
D
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
S
S
R
--
V
-
H
P
--
H
-------------
A
-------------
S
K
-
A
--
Q
P
G
S
V
I
S
V
A
--
P
L
L
I
A
C
G
-
D
G
A
L
E
I
V
T
G
Q
A
G
D
G
I
T
M
Q
G
S
Q
L
A
Q
T
L
G
L
V
Q
G
S
R
L
R
R
T
R
56
Fugue
75.03
24%
-89
- C4 -
1S3I
5
AL1L1_RAT
A:
[1-307]
-
M
K
I
A
V
I
G
Q
S
L
F
G
Q
E
V
Y
C
Q
L
R
K
E
G
-
H
E
V
V
G
V
F
T
I
P
D
K
D
G
K
A
------
D
P
D
G
L
E
A
E
K
D
G
V
P
V
F
K
-
F
P
-
R
W
R
A
-----
R
G
Q
AL
P
E
V
V
A
K
Y
Q
A
L
G
A
E
L
N
V
L
P
F
C
S
Q
F
I
P
M
E
V
I
N
-
A
P
R
H
G
S
I
I
Y
H
P
S
L
L
P
R
H
R
G
A
S
A
I
N
W
T
L
I
H
G
D
K
K
G
G
F
T
I
F
W
A
D
D
G
L
D
T
G
D
L
L
L
Q
K
E
C
E
V
L
P
D
D
T
V
S
T
L
Y
N
R
F
L
F
-
P
E
G
I
K
G
M
V
Q
A
V
R
L
I
A
E
G
T
A
P
R
C
P
Q
S
E
E
G
A
T
Y
E
G
I
Q
K
K
E
T
A
K
I
N
W
D
Q
P
A
E
A
I
H
N
W
I
R
G
N
-
D
-
K
V
P
G
A
W
T
E
A
C
G
Q
K
L
T
F
F
--
N
--
S
-
T
L
--
N
TSGLSTQ
G
E
A
L
P
I
P
-------------
G
A
-
H
--
R
P
G
V
V
T
--
K
A
G
L
I
L
F
G
N
D
-
D
R
M
L
L
V
K
N
I
Q
L
E
D
G
K
M
M
P
A
S
Q
F
F
K
--------------
70
HHSearch
73.94
23%
-87
- C4 -
2BW0
3
AL1L1_HUMAN
A:
[22-329]
S
M
K
I
A
V
I
G
Q
S
L
F
G
Q
E
V
Y
C
H
L
R
K
-
E
G
H
E
V
V
G
V
F
T
V
P
D
K
D
G
------
K
A
D
P
L
G
L
E
A
E
K
D
G
V
P
V
F
K
-
Y
S
-
R
W
R
A
KGQAL
P
D
V
-----
V
A
K
Y
Q
A
L
G
A
E
L
N
V
L
P
F
C
S
Q
F
I
P
M
E
I
I
S
-
A
P
R
H
G
S
I
I
Y
H
P
S
L
L
P
R
H
R
G
A
S
A
I
N
W
T
L
I
H
G
D
K
K
G
G
F
S
I
F
W
A
D
D
G
L
D
T
G
D
L
L
L
Q
K
E
C
E
V
L
P
D
D
T
V
S
T
L
Y
N
R
-
F
L
F
P
E
G
I
K
G
M
V
Q
A
V
R
L
I
A
E
G
K
A
P
R
L
P
Q
P
E
E
G
A
T
Y
E
G
I
Q
K
K
E
T
A
K
I
N
W
D
Q
P
A
E
A
I
H
N
W
I
R
G
N
-
D
-
K
V
P
G
A
W
T
E
A
C
E
Q
K
L
T
F
F
--
N
--
S
-
T
L
--
N
-------------
T
SGLVPE
G
D
A
L
P
I
P
G
A
-
H
--
R
P
G
V
V
T
K
--
A
G
L
I
L
F
G
N
D
-
D
K
M
L
L
V
K
N
I
Q
L
E
D
G
K
M
I
L
A
S
N
F
F
K
--------------
10
PsiBlast_PDB
71.71
25%
-94
- C4 -
4QPD
3
?
A:
[2-277]
--
K
I
A
V
I
G
Q
S
L
F
G
Q
E
V
Y
K
E
L
K
N
E
G
-
H
M
I
V
G
V
F
T
I
P
D
------
K
D
G
K
V
D
P
L
A
I
E
A
E
K
D
G
V
P
V
F
K
F
P
R
W
R
L
K
G
KAI--
T
E
V
-----
V
D
Q
Y
K
A
V
G
A
E
L
N
V
L
P
F
C
S
Q
F
I
P
M
E
V
I
D
-
H
P
K
H
G
S
I
I
Y
H
P
S
L
L
P
R
H
R
G
A
S
A
I
N
W
T
L
I
H
G
D
K
K
G
G
F
T
V
F
W
A
D
D
G
L
D
T
G
P
I
L
L
Q
R
E
C
D
V
E
P
N
D
N
V
N
S
I
Y
K
R
F
L
F
-
P
E
G
V
K
G
M
V
E
A
V
R
L
I
A
T
G
K
A
P
R
I
K
Q
P
E
E
G
A
T
Y
E
C
I
Q
K
K
E
N
S
K
I
D
W
N
Q
P
A
E
A
I
H
N
W
I
R
G
N
-
D
-
R
V
P
G
A
W
A
E
I
D
G
K
S
V
S
F
Y
--
G
--
S
-
T
L
--
L
-------------
E
NDHFS--------
S
N
-
G
--
Q
P
L
E
I
P
G
A
S
R
A
A
L
V
T
K
N
G
-
L
V
L
F
G
N
D
G
K
M
L
L
V
K
N
L
Q
F
E
D
G
K
M
I
P
G
S
Q
Y
F
K
-------
12
PsiBlast_PDB
71.41
25%
-95
- C4 -
4TT8
2
?
A:
[2-277]
--
K
I
A
V
I
G
Q
S
L
F
G
Q
E
V
Y
K
E
L
K
N
E
G
-
H
M
I
V
G
V
F
T
I
P
D
------
K
D
G
K
V
D
P
L
A
I
E
A
E
K
D
G
V
P
V
F
K
F
P
R
W
R
L
K
G
KAI--
T
E
V
-----
V
D
Q
Y
K
A
V
G
A
E
L
N
V
L
P
F
C
S
Q
F
I
P
M
E
V
I
D
-
H
P
K
H
G
S
I
I
Y
H
P
S
L
L
P
R
H
R
G
A
S
A
I
N
W
T
L
I
H
G
D
K
K
G
G
F
T
V
F
W
A
D
D
G
L
D
T
G
P
I
L
L
Q
R
E
C
D
V
E
P
N
D
N
V
N
S
I
Y
K
R
F
L
F
-
P
E
G
V
K
G
M
V
E
A
V
R
L
I
A
T
G
K
A
P
R
I
K
Q
P
E
E
G
A
T
Y
E
C
I
Q
K
K
E
N
S
K
I
D
W
N
Q
P
A
E
A
I
H
N
W
I
R
G
N
-
D
-
R
V
P
G
A
W
A
E
I
D
G
K
S
V
S
F
Y
--
G
--
S
-
T
L
--
L
-------------
E
NDHFS--------
S
N
-
G
--
Q
P
L
E
I
P
G
A
S
R
A
A
L
V
T
K
N
G
-
L
V
L
F
G
N
D
G
K
M
L
L
V
K
N
L
Q
F
E
D
G
K
M
I
P
G
S
Q
Y
F
K
-------