@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1740: (2015-12-10 )
MKSKLMDKYGITEDSSIDLIKASIASFWKNVVYMFPITLILFFLMNISNSKYLQEWFYFVSILIVFVVMYYFTNRQYIKSYSTTFKGSKNLRIELVEIIKRLPLSYFSTHDLTDLSQTVMADVSKIEQALSHAICAYYGWIGYFVFLSLSLLIGSLQLGLCIIVPVITALLILYLSKNIQYRINRKYYKKLRENSQAFQDSFEMQQDIKSYNMQHTVRKDVQDKLKDSEKIQIKTELFTTIPSSLLSILPQFSIALVIIFGFQLYLTGQIQLIFYIGYIICATKVASGFTGMLDSLLMIINFQSSFKQVTAIRKTPLQEGVNADIQTFNVEFRDVSFAYEKGRNVVSNLSFNANQGEVTAIVGPSGCGKSTILKLLSRLYDYNAGQILIGGKDISEISTNSLFENISTVFQDVELFDDTIFENIKCGNPKATIEEVLEAAKIANVDEIADKFVDKYDTKIGENGSKLSGGERQRISIARAILKDAPIILLDEISASLDIENEIKIQAGLDKLIKNKTVIIVSHRMKSIENANKIIVIENGKVENFGTHSYLLENSTRYRKLVECSQLASEYEY
Atome Classification :
(29 SA)
.........10........20........30........40........50..---.......60-.---..---..--...70........80........---90........100.......110.......120.......130.......140.......150.......160..--.....170.......180.......190....--..-.200.......210.-----......220-----......-.230-.......240.......250.......260----........270.......280.......290....--------...300....---...310....-----.---------..-320-.-------..---.....---.--330.......340.--.-.--.--.--...350.......360.......370.......380.---......390.......400.......410.......420.....--..-430-.-..--......440.......450.......460.......470.......480.......490.......500.......510.--......520.......530.......540.......550..--.....560.......570.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKS
K
L
M
D
KYGITEDSS
I
D
L
I
K
A
S
I
A
S
F
W
K
N
V
V
Y
M
F
P
I
T
L
I
L
F
F
L
M
NISN
S
-
K
Y
---
L
Q
E
W
F
Y
F
V
S
-
I
---
L
I
---
V
F
--
V
V
M
Y
Y
FT
N
R
Q
Y
I
K
S
YSTTFKGSK---
N
L
R
I
E
L
V
E
I
I
K
RL
P
L
S
Y
FSTHD
L
T
D
L
S
Q
T
V
M
A
D
V
S
K
I
E
Q
A
L
S
H
A
I
C
A
Y
Y
G
W
I
G
Y
F
V
F
L
S
L
S
L
L
I
G
S
L
Q
L
G
L
C
I
I
V
--
P
V
I
T
A
L
L
I
L
Y
LSKN
I
Q
Y
R
I
N
R
K
Y
Y
K
K
L
R
EN
S
Q
--
A
F
-
Q
D
S
F
E
M
Q
Q
D
I
K
S
Y
N
M
-----
Q
H
T
V
R
K
D
V
Q
-----
D
K
LKDS-
E
K
I
Q
-
I
K
T
E
L
F
T
T
I
P
S
S
L
L
S
I
L
P
Q
F
S
I
A
L
V
I
I
FG-----
F
Q
L
Y
L
TG
Q
I
Q
L
I
F
Y
I
G
Y
I
I
C
A
T
K
V
AS
G
F
T
G
M
L
D
S
L
--------
L
M
I
INF
Q
S
S
F
---
K
Q
V
T
A
I
R
K
T
P
-----
L
---------
Q
E-G---V-------NA---D
I
Q
T
F
---
N
--
V
E
F
R
D
V
S
F
A
Y
E
-KG--R-
N
--
V
--
V
--
S
NLSFNANQ
G
E
V
T
A
I
VGPSGC
G
K
S
T
I
L
K
L
L
S
R
LYDYN---A
G
Q
I
L
IGG
K
D
I
S
E
I
S
T
N
S
L
F
E
N
I
S
T
V
F
Q
D
V
E
L
F
D
D
T
I
F
ENIKCG--N
P
-
K
---
A
-
T
I
--
E
E
V
L
E
A
AKIA
N
V
D
E
I
A
D
K
F
V
D
K
YDTKIGENGSKLSGGE
R
Q
R
I
S
I
A
R
A
I
LKDA
P
I
I
L
L
DEISASLDIE
N
E
I
K
I
Q
A
G
L
D
K
L
I--KNK
T
V
I
I
V
S
H
R
M
K
SIENA
N
K
I
I
V
I
ENGKVENFGT
H
S
Y
L
LEN--
S
T
R
Y
R
K
L
V
E
C
S
Q
L
A
S
EYEY
121
HHSearch
81.85
25%
-87
- C1 -
3B60
2
MSBA_SALTY
A:
[19-581]
----------
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
R
---
S
V
L
L
W
M
P
L
V
V
I
---
G
L
---
M
I
L
R
G
I
T
S
Y
I
S
S
Y
---
C
I
S
W
V
S
G
K
V
V
M
---
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
--
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
--
S
A
-
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
-----
Q
E
V
E
T
K
R
F
D
-----
K
V
S
N
K
M
-
R
L
Q
G
-
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
-----
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
--------
A
Q
F
Q
R
G
M
A
A
C
---
Q
T
L
F
A
I
L
D
S
E
-----
Q
---------
E
K
-
D
E
G
K
R
-------
V
I
---
D
R
A
T
G
---
D
--
L
E
F
R
N
V
T
F
T
Y
P
-
G
R
E-
V
-
P
--
A
--
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
--
R
T
-
E
E--
Y
-
S
R
--
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
------
4
PsiBlast_PDB
80.01
30%
-98
- C1 -
4Q4J
-
Y288_THEMA
B:
[112-586]
----------------------------------------------------------------------------------------------------------
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
--
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
--
L
S
I
V
P
L
T
V
L
I
--
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
---
E
N
Q
R
--
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
-----
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
-
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
-----
G
W
L
A
L
K
D
----
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
---
E
I
L
D
L
E
E
E
K
D
-----
D
---------
P
D
-
A
---
V
-------
E
L
---
R
E
V
R
G
---
E
--
I
E
F
K
N
V
W
F
S
Y
D
-
K
K
--
K
-
P
--
V
--
L
--
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
--
N
P
-
G
---
A
-
T
D
--
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
------
124
HHSearch
78.77
24%
-99
- C1 -
3WMG
5
?
A:
[29-598]
------------------
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
S
Q
I
E
-
G
E
T
W
K
Y
S
V
G
-
F
---
V
G
I
G
V
F
E
--
F
I
V
A
G
S
R
T
A
---
L
F
G
I
A
S
E
R
L
A
R
---
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
L
G
-
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
--
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
--
V
A
-
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
-----
E
R
Y
E
T
Q
R
Y
G
-----
S
K
L
D
P
L
-
Y
R
L
G
-
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
-----
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
--------
P
D
V
T
R
G
L
G
A
G
---
G
E
L
F
A
M
I
D
R
V
-----
P
---------
Q
Y
R
R
P--
D
PG
A
E
V
V
T
Q
P
---
L
V
L
K
Q
---
G
--
I
V
F
E
N
V
H
F
R
Y
P
-
T
R
MN
V
-
E
--
V
--
L
--
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
--
K
R
-
D
---
A
-
T
D
--
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
GP
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
-----
16
PsiBlast_PDB
78.28
29%
-83
- C1 -
3B60
2
MSBA_SALTY
A:
[69-575]
----------------------------------------------------------------------
L
V
---
V
I
--
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
----------
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
-
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
VLIFG
G
Q
E
V
E
T
K
R
F
-----
D
K
V
S
N
K
-
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
FPSV
M
D
S
L
T
A
G
T
I
T
V
V
F
------------
S
S
M
I
A
L
M
R
P
L
--------
K
S
L
T
N
V
N
A
Q
F
---
Q
R
G
M
A
A
C
Q
T
L
-----
F
A
I
L
D
SEQEK
D
E
-
G
---
K
-------
R
V
I--
D
R
A
T
G
---
D
--
L
E
F
R
N
V
T
F
T
Y
--
P
G
--
R
-
E
--
V
PA
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
--
R
T
-
E
---
E
Y
S
R
--
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
------
2
PsiBlast_PDB
78.18
30%
-102
- C1 -
4Q4A
1
Y288_THEMA
B:
[112-586]
----------------------------------------------------------------------------------------------------------
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
--
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
--
L
S
I
V
P
L
T
V
L
I
--
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
---
E
N
Q
R
--
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
-----
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
-
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
-----
G
W
L
A
L
K
D
----
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
---
E
I
L
D
L
E
E
E
K
D
-----
D
---------
P
D
-
A
---
V
-------
E
L
---
R
E
V
R
G
---
E
--
I
E
F
K
N
V
W
F
S
Y
D
-
K
K
--
K
-
P
--
V
--
L
--
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
--
N
P
-
G
---
A
-
T
D
--
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
L
-----
1
PsiBlast_PDB
77.73
30%
-100
- C1 -
3QF4
1
Y288_THEMA
B:
[112-586]
----------------------------------------------------------------------------------------------------------
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
--
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
--
L
S
I
V
P
L
T
V
L
I
--
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
---
E
N
Q
R
--
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
-----
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
-
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
-----
G
W
L
A
L
K
D
----
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
---
E
I
L
D
L
E
E
E
K
D
-----
D
---------
P
D
-
A
---
V
-------
E
L
---
R
E
V
R
G
---
E
--
I
E
F
K
N
V
W
F
S
Y
D
-
K
K
--
K
-
P
--
V
--
L
--
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
--
N
P
-
G
---
A
-
T
D
--
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
L
V
V
E
K
-
3
PsiBlast_PDB
77.34
30%
-97
- C1 -
4Q4H
-
Y288_THEMA
B:
[112-586]
----------------------------------------------------------------------------------------------------------
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
--
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
--
L
S
I
V
P
L
T
V
L
I
--
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
---
E
N
Q
R
--
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
-----
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
-
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
-----
G
W
L
A
L
K
D
----
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
---
E
I
L
D
L
E
E
E
K
D
-----
D
---------
P
D
-
A
---
V
-------
E
L
---
R
E
V
R
G
---
E
--
I
E
F
K
N
V
W
F
S
Y
D
-
K
K
--
K
-
P
--
V
--
L
--
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
--
N
P
-
G
---
A
-
T
D
--
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
------
20
PsiBlast_PDB
75.03
40%
-94
- C1 -
4Q9H
-
MDR1A_MOUSE
A:
[1008-1267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
K
T
P
EIDSY
S
---------
T
Q
-
G
---
L
-------
K
P
---
N
M
L
E
G
---
N
--
V
Q
F
S
G
V
V
F
N
Y
P
-
T
R
--
P
-
S
IP
V
--
L
--
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
S
I
A
E
N
I
A
Y
G
--
D
N
-
S
---
R
-
V
V
S
Y
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
F
S
M
V
S
V
Q
A
G
A
-----
19
PsiBlast_PDB
74.86
40%
-92
- C1 -
4M1M
3
MDR1A_MOUSE
A:
[1008-1267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
K
T
P
EIDSY
S
---------
T
Q
-
G
---
L
-------
K
P
---
N
M
L
E
G
---
N
--
V
Q
F
S
G
V
V
F
N
Y
P
-
T
R
--
P
-
S
IP
V
--
L
--
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
S
I
A
E
N
I
A
Y
G
--
D
N
-
S
---
R
-
V
V
S
Y
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
F
S
M
V
S
V
Q
A
-------
112
Fugue
74.12
22%
-81
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
-
D
R
---
S
V
L
L
W
M
P
L
V
-
V
---
I
G
---
L
M
--
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
---
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
--
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
--
S
A
-
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
-----
Q
E
V
E
T
K
R
F
D
-----
K
V
S
N
K
M
-
R
L
Q
G
-
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
-----
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
--------
A
Q
F
Q
R
G
M
A
A
C
---
Q
T
L
F
A
I
L
D
S
E
-----
Q
---------
E
K
-
D
---
E
-------
G
K
---
R
V
I
D
R
ATG
D
--
L
E
F
R
N
V
T
F
T
Y
P
G
R
E
--
V
-
P
--
A
--
L
--
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
--
R
T
E
E
---
Y
-
S
R
--
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
------
18
PsiBlast_PDB
73.76
40%
-90
- C1 -
4M2T
-
MDR1A_MOUSE
A:
[1008-1267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
K
T
P
EIDSY
S
---------
T
Q
-
G
---
L
-------
K
P
---
N
M
L
E
G
---
N
--
V
Q
F
S
G
V
V
F
N
Y
P
-
T
R
--
P
-
S
IP
V
--
L
--
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
S
I
A
E
N
I
A
Y
G
--
D
N
-
S
---
R
-
V
V
S
Y
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
F
S
M
V
S
V
Q
A
-------
122
HHSearch
73.40
23%
-90
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[6-572]
---
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
DY
S
D
N
L
T
R
L
C
L
G
-
L
S
A
V
F
L
---
C
G
--
A
A
A
N
A
I
R
V
Y
---
L
M
Q
T
S
G
Q
R
I
V
N
---
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
--
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
--
L
A
-
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
-----
E
M
T
E
I
E
K
Y
A
-----
S
K
V
D
H
V
-
M
Q
L
A
-
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
-----
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
--------
S
E
L
M
K
G
L
G
A
G
---
G
R
L
W
E
L
L
E
R
E
-----
P
---------
K
L
-
P
F
N
-
E
G
V
I
L
---
N
E
---
K
S
F
Q
G
---
A
--
L
E
F
K
N
V
H
F
A
Y
P
-
A
R
PE
V
-
P
--
I
--
F
--
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
--
A
D
-
D
PSS
V
-
T
A
--
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P--------------------
17
PsiBlast_PDB
73.33
40%
-88
- C1 -
4M2S
-
MDR1A_MOUSE
A:
[1008-1267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
K
T
P
EIDSY
S
---------
T
Q
-
G
---
L
-------
K
P
---
N
M
L
E
G
---
N
--
V
Q
F
S
G
V
V
F
N
Y
P
-
T
R
--
P
-
S
IP
V
--
L
--
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
S
I
A
E
N
I
A
Y
G
--
D
N
-
S
---
R
-
V
V
S
Y
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
F
S
M
V
S
V
Q
A
-------
31
PsiBlast_CBE
72.77
40%
-96
- C1 -
4LSG
3
MDR1A_MOUSE
A:
[1008-1267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
K
T
P
EIDSY
S
---------
T
Q
-
G
---
L
-------
K
P
---
N
M
L
E
G
---
N
--
V
Q
F
S
G
V
V
F
N
Y
P
-
T
R
--
P
-
S
IP
V
--
L
--
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
S
I
A
E
N
I
A
Y
G
--
D
N
-
S
---
R
-
V
V
S
Y
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
F
S
M
V
S
V
Q
A
-------
25
PsiBlast_CBE
72.20
40%
-85
- C1 -
4M1M
3
MDR1A_MOUSE
B:
[1008-1267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
K
T
P
EIDSY
S
---------
T
Q
-
G
---
L
-------
K
P
---
N
M
L
E
G
---
N
--
V
Q
F
S
G
V
V
F
N
Y
P
-
T
R
--
P
-
S
IP
V
--
L
--
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
S
I
A
E
N
I
A
Y
G
--
D
N
-
S
---
R
-
V
V
S
Y
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
F
S
M
V
S
V
Q
A
-------
32
PsiBlast_CBE
72.03
40%
-81
- C1 -
3G5U
3
MDR1A_MOUSE
B:
[1008-1267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
K
T
P
EIDSY
S
---------
T
Q
-
G
---
L
-------
K
P
---
N
M
L
E
G
---
N
--
V
Q
F
S
G
V
V
F
N
Y
P
-
T
R
--
P
-
S
IP
V
--
L
--
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
S
I
A
E
N
I
A
Y
G
--
D
N
-
S
---
R
-
V
V
SY
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
F
S
M
V
S
V
Q
A
-------
33
PsiBlast_CBE
71.16
40%
-82
- C1 -
3G5U
3
MDR1A_MOUSE
A:
[1008-1267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
K
T
P
EIDSY
S
---------
T
Q
-
G
---
L
-------
K
P
---
N
M
L
E
G
---
N
--
V
Q
F
S
G
V
V
F
N
Y
P
-
T
R
--
P
-
S
IP
V
--
L
--
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
S
I
A
E
N
I
A
Y
G
--
D
N
-
S
---
R
-
V
V
S
Y
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
F
S
M
V
S
V
Q
A
-------
30
PsiBlast_CBE
70.86
40%
-95
- C1 -
4LSG
3
MDR1A_MOUSE
B:
[1008-1267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
K
T
P
EIDSY
S
---------
T
Q
-
G
---
L
-------
K
P
---
N
M
L
E
G
---
N
--
V
Q
F
S
G
V
V
F
N
Y
P
-
T
R
--
P
-
S
IP
V
--
L
--
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
S
I
A
E
N
I
A
Y
G
--
D
N
-
S
---
R
-
V
V
SY
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
F
S
M
V
S
V
Q
A
-------
22
PsiBlast_CBE
70.08
43%
-93
- C1 -
2HYD
3
Y1866_STAAM
B:
[324-578]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---------
K
N
-
G
---
V
-------
G
A
QPI
E
I
K
Q
G
---
R
--
I
D
I
D
H
V
S
F
Q
Y
N
-
D
N
--
E
A
P
--
I
--
L
--
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
--
R
P
-
T
---
A
-
T
D
--
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
------
11
PsiBlast_PDB
69.60
43%
-93
- C1 -
2HYD
3
Y1866_STAAM
A:
[324-578]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---------
K
N
-
G
---
V
-------
G
A
QPI
E
I
K
Q
G
---
R
--
I
D
I
D
H
V
S
F
Q
Y
N
-
D
N
--
E
A
P
--
I
--
L
--
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
--
R
P
-
T
---
A
-
T
D
--
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
------
21
PsiBlast_CBE
69.50
43%
-91
- C1 -
2ONJ
4
Y1866_STAAM
B:
[324-578]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---------
K
N
-
G
---
V
-------
G
A
QPI
E
I
K
Q
G
---
R
--
I
D
I
D
H
V
S
F
Q
Y
N
-
D
N
--
E
A
P
--
I
--
L
--
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
--
R
P
-
T
---
A
-
T
D
--
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
------
12
PsiBlast_PDB
68.57
43%
-91
- C1 -
2ONJ
4
Y1866_STAAM
A:
[324-578]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---------
K
N
-
G
---
V
-------
G
A
QPI
E
I
K
Q
G
---
R
--
I
D
I
D
H
V
S
F
Q
Y
N
-
D
N
--
E
A
P
--
I
--
L
--
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
--
R
P
-
T
---
A
-
T
D
--
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
------
8
PsiBlast_PDB
67.88
41%
-84
- C1 -
3NHA
4
A:
[21-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
I
D
M
E
N
M
F
D
L
L
K
E
E
T
E
V
K
D
L
P
-----
G
---------
A
G
-
P
---
L
-------
R
-----
F
Q
K
G
---
R
--
I
E
F
E
N
V
H
F
S
Y
A
-
D
---
R
-
E
--
T
--
L
--
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
--
R
V
-
T
---
A
-
G
N
--
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
G
V
Y
A
D
M
W
Q
L
Q
Q
G
Q
-----
7
PsiBlast_PDB
67.11
41%
-81
- C1 -
3NH9
3
A:
[21-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
I
D
M
E
N
M
F
D
L
L
K
E
E
T
E
V
K
D
L
P
-----
G
---------
A
G
-
P
---
L
-------
R
-----
F
Q
K
G
---
R
--
I
E
F
E
N
V
H
F
S
Y
A
-
D
G
--
R
-
E
--
T
--
L
--
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
--
R
V
-
T
---
A
-
G
N
--
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
G
V
Y
A
D
M
W
Q
L
Q
Q
G
Q
-----
9
PsiBlast_PDB
65.77
41%
-83
- C1 -
3NHB
3
A:
[21-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
I
D
M
E
N
M
F
D
L
L
K
E
E
T
E
V
K
D
L
P
-----
G
---------
A
G
-
P
---
L
-------
R
-----
F
Q
K
G
---
R
--
I
E
F
E
N
V
H
F
S
Y
A
-
D
---
R
-
E
--
T
--
L
--
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
--
R
V
-
T
---
A
-
G
N
--
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
G
V
Y
A
D
M
W
Q
L
Q
Q
G
Q
-----
39
PsiBlast_CBE
64.70
42%
-81
- C1 -
4AYW
1
ABCBA_HUMAN
A:
[355-598]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
-----
F
---------
N
E
-
G
---
V
-------
I
L
---
N
E
K
S
F
---
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
-
A
R
--
P
-
E
--
V
--
P
IF
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
AD
D
P
-
S
---
S
V
T
A
--
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-------------------------
35
PsiBlast_CBE
63.25
41%
-77
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[324-574]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
-----
F
---------
N
E
-
G
---
V
-------
I
L
---
N
E
K
S
F
---
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
-
A
R
--
P
-
E
--
V
--
P
IF
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
AD
D
P
-
S
---
S
V
T
A
--
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
--
P
N
G
----------------
36
PsiBlast_CBE
60.70
41%
-74
- C1 -
4AYT
2
ABCBA_HUMAN
A:
[324-567]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
P
-----
F
---------
N
E
-
G
---
V
-------
I
L
---
N
E
K
S
F
---
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
-
A
R
--
P
-
E
--
V
--
P
IF
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
AD
D
P
-
S
---
S
V
T
A
--
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-------------------------
130
HHSearch
55.92
38%
-82
- C1 -
1MV5
3
LMRA_LACLA
A:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
D
-
D
S
--
E
-
Q
--
I
--
L
--
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
--
L
E
-
G
D--
Y
-
T
D
--
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
L
T
V
G
----