@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1906: (2015-12-11 )
MSENLGQLAINQARENGGKLEVISKVKVEDKRDLSIAYTPGVASVSSAIAEDVELAYELTTKKNTVAVVSDGSAVLGLGDIGPEAAMPVMEGKAALFKRFANVDAVPIVLKTNDTEEIISIVKAISPTFGGINLEDISAPRCFEIEQRLIEECDIPVFHDDQHGTAIVVLAALFNSLKLVKKDIEDIRVVVNGGGSAGLSITRKLLSAGAKHVTVVDRFGIINDKDRESLAPHHKAIAKLTNREFQSGSLEDALENADVFIGVSAPEALHAEWISKMADKPIVFAMANPIPEIYPDQALKAGAYIVGTGRSDFPNQINNVLAFPGIFRGALDARAKTITVEMQIAAARGIASLIPEEELSTTHIIPNAFQNDVADVVAKSVSNAVQK
Atome Classification :
(20 SA)
.........10....---....20........30.........40........50------------.........60-..--.......70........80....-....90........100.---.---.....110---------------------..------.------......------------------------120---------------------.........130-.---........140.......150-.......160.......170.......180.......190.......200......----------.----------210.--........220---........--.-230.......240--..-----.......250...--...--.260..--.--..-..270....-..---.---280.......290-.......--.300........-----------.310---------.....-----------....320.......330.......340.......350........360...-----.--...370........380.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSE
N
L
G
Q
L
A
I
N
Q
A
RE---NGG
K
L
E
V
I
S
K
V
KVED-KR
D
L
S
I
A
YTPG
V
A
S
V
S
S
A
I
A
-------------
E
D
V
E
L
A
Y
E
LT--TK--K
N
T
V
A
V
VSDG
S
A
V
L
GLGDI
G
P
E
A-AM
P
V
ME
G
K
A
A
L
F
K
R
F
ANV---
D
---
A
V
P
I
V
L
-----------------------KT------N------
D
T
E
E
I
I
------------------------
S
-----------------------
I
V
K
A
ISPTFG---G---I
N
L
E
DISAP
R
C
F
E
I
E
Q
R
L
I
E
E-CDIP
V
F
HDDQH
G
T
A
I
V
V
L
A
A
L
F
N
S
L
K
L
V
K
K
D
I
E
D
I
R
V
V
V
NGGGS
A
G
L
S
I
T
R
K
L
L
SA----------G----------A--
K
--
H
V
T
V
V
D
RFG-----IINDK
D
R
E
--S-L
A
P
H
H
K
A
I
A
K
L
----
T
N-----REFQSG
S
L
E
D
A
LE--NA
D
--
V
F
I
GVS--A--
P
E
-
A
L
H
A
E
W
I
S
K
-MA---D---K
P
I
V
F
A
MANPIP--EIYP
D
Q
A--LK--A
G
A
Y
I
V
GT-----------GR-----------SD
F
P
N
-----------
Q
I
N
N
VLAF
P
G
I
F
R
G
A
LDAR
A
K
T
I
T
V
E
M
Q
I
A
A
AR
G
I
A
-
S
LI
P
E
EELSTTHII-----
P
--
N
A
F
Q
N
-
D
V
A
D
V
V
A
K
S
V
S
N
A
VQK
34
HHSearch
86.69
79%
-105
- C5 -
2A9F
1
?
A:
[4-388]
-
K
N
Q
L
G
Q
L
A
L
E
Q
A
K
T
---
F
G
G
K
L
E
V
Q
P
K
V
D
I
K
T
-
K
H
D
L
S
I
A
Y
T
P
G
V
A
S
V
S
S
A
I
A
-------------
K
D
K
T
L
A
Y
D
L
T
--
T
K
--
K
N
T
V
A
V
I
S
D
G
T
A
V
L
G
L
G
D
I
G
P
E
A
-
A
M
P
V
M
E
G
K
A
A
L
F
K
A
F
A
G
V
---
D
---
A
I
P
I
V
L
-----------------------
D
T
------
K
------
D
T
E
E
I
I
------------------------
S
-----------------------
I
V
K
A
L
A
P
T
F
G
---
G
---
I
N
L
E
D
I
S
A
P
R
C
F
E
I
E
Q
R
L
I
K
E
-
C
H
I
P
V
F
H
D
D
Q
H
G
T
A
I
V
V
L
A
A
I
F
N
S
L
K
L
L
K
K
S
L
D
E
V
S
I
V
V
N
G
G
G
S
A
G
L
S
I
T
R
K
L
L
A
A
----------
G
----------
A
--
T
--
K
V
T
V
V
D
K
F
G
-----
I
I
N
E
Q
E
A
A
--
Q
-
L
A
P
---
D
I
A
K
V
----
T
N
-----
R
E
F
K
S
G
T
L
E
D
A
L
E
--
G
A
D
--
I
F
I
G
V
S
--
A
--
P
G
-
V
L
K
A
E
W
I
S
K
-
M
A
---
A
---
R
P
V
I
F
A
M
A
N
P
I
P
--
E
I
Y
P
D
E
A
--
L
E
--
A
G
A
Y
I
V
G
T
-----------
G
R
-----------
S
D
F
P
N
-----------
Q
I
N
N
V
L
A
F
P
G
I
F
R
G
A
L
D
A
R
A
K
T
I
T
V
E
M
Q
I
A
A
A
K
G
I
A
-
S
L
V
P
D
D
A
L
S
T
T
N
I
I
-----
P
--
D
A
F
K
E
-
G
V
A
E
I
V
A
K
S
V
R
S
V
V
L
-
1
PsiBlast_PDB
86.48
78%
-105
- C5 -
2A9F
1
?
A:
[3-388]
L
K
N
Q
L
G
Q
L
A
L
E
Q
A
K
T
---
F
G
G
K
L
E
V
Q
P
K
V
D
I
K
T
-
K
H
D
L
S
I
A
Y
T
P
G
V
A
S
V
S
S
A
I
A
-------------
K
D
K
T
L
A
Y
D
L
T
--
T
K
--
K
N
T
V
A
V
I
S
D
G
T
A
V
L
G
L
G
D
I
G
P
E
A
-
A
M
P
V
M
E
G
K
A
A
L
F
K
A
F
A
G
V
---
D
---
A
I
P
I
V
L
-----------------------
D
T
------
K
------
D
T
E
E
I
I
------------------------
S
-----------------------
I
V
K
A
L
A
P
T
F
G
---
G
---
I
N
L
E
D
I
S
A
P
R
C
F
E
I
E
Q
R
L
I
K
E
-
C
H
I
P
V
F
H
D
D
Q
H
G
T
A
I
V
V
L
A
A
I
F
N
S
L
K
L
L
K
K
S
L
D
E
V
S
I
V
V
N
G
G
G
S
A
G
L
S
I
T
R
K
L
L
A
A
----------
G
----------
A
--
T
--
K
V
T
V
V
D
K
F
G
-----
I
I
N
E
Q
E
A
A
--
Q
-
L
A
P
---
D
I
A
K
V
----
T
N
-----
R
E
F
K
S
G
T
L
E
D
A
L
E
--
G
A
D
--
I
F
I
G
V
S
--
A
--
P
G
-
V
L
K
A
E
W
I
S
K
-
M
A
---
A
---
R
P
V
I
F
A
M
A
N
P
I
P
--
E
I
Y
P
D
E
A
--
L
E
--
A
G
A
Y
I
V
G
T
-----------
G
R
-----------
S
D
F
P
N
-----------
Q
I
N
N
V
L
A
F
P
G
I
F
R
G
A
L
D
A
R
A
K
T
I
T
V
E
M
Q
I
A
A
A
K
G
I
A
-
S
L
V
P
D
D
A
L
S
T
T
N
I
I
-----
P
--
D
A
F
K
E
-
G
V
A
E
I
V
A
K
S
V
R
S
V
V
L
-
26
PsiBlast_CBE
85.86
53%
-109
- C5 -
2DVM
3
?
C:
[18-394]
--------------------
G
K
I
E
V
I
P
K
V
S
L
E
S
-
R
E
E
L
T
L
A
Y
T
P
G
V
A
E
P
C
K
E
I
A
-------------
R
D
P
G
K
V
Y
E
Y
T
--
S
K
--
G
N
L
V
A
V
V
S
D
G
S
R
I
L
G
L
G
N
I
G
P
L
A
-
G
L
P
V
M
E
G
K
A
L
L
F
K
R
F
G
G
V
---
D
---
A
F
P
I
M
I
-----------------------
K
E
------
Q
------
E
P
N
K
F
I
------------------------
D
-----------------------
I
V
K
A
I
A
P
T
F
G
---
G
---
I
N
L
E
D
I
A
S
P
K
C
F
Y
I
L
E
R
L
R
E
E
-
L
D
I
P
V
F
H
D
D
Q
Q
G
T
A
A
V
V
L
A
G
L
L
N
A
L
K
V
V
G
K
K
I
S
E
I
T
L
A
L
F
G
A
G
A
A
G
F
A
T
L
R
I
L
T
E
A
----------
G
----------
V
--
K
PE
N
V
R
V
V
E
L
V
N
GKPRI
L
T
S
D
L
D
L
E
--
K
-
L
F
P
Y
R
G
W
L
L
K
K
----
T
N
-----
G
E
N
I
E
G
G
P
Q
E
A
L
K
--
D
A
D
--
V
L
I
S
F
T
RP
G
--
P
G
-
V
I
K
P
Q
W
I
E
K
-
M
N
---
E
---
D
A
I
V
F
P
L
A
N
P
V
P
--
E
I
L
P
E
E
A
--
K
K
--
A
G
A
R
I
V
A
T
-----------
G
R
-----------
S
D
Y
P
N
-----------
Q
I
N
N
L
L
G
F
P
G
I
F
R
G
A
L
D
V
R
A
R
T
I
T
D
S
M
I
I
A
A
A
K
A
I
A
-
S
I
V
--
E
E
P
S
E
E
N
I
I
-----
P
--
S
P
L
N
P
-
I
V
Y
A
R
E
A
R
A
V
A
E
E
A
M
K
21
PsiBlast_CBE
85.86
78%
-95
- C5 -
2A9F
1
?
B:
[3-385]
L
K
N
Q
L
G
Q
L
A
L
E
Q
A
K
T
---
F
G
G
K
L
E
V
Q
P
K
V
D
I
K
T
-
K
H
D
L
S
I
A
Y
T
P
G
V
A
S
V
S
S
A
I
A
-------------
K
D
K
T
L
A
Y
D
L
T
--
T
K
--
K
N
T
V
A
V
I
S
D
G
T
A
V
L
G
L
G
D
I
G
P
E
A
-
A
M
P
V
M
E
G
K
A
A
L
F
K
A
F
A
G
V
---
D
---
A
I
P
I
V
L
-----------------------
D
T
------
K
------
D
T
E
E
I
I
------------------------
S
-----------------------
I
V
K
A
L
A
P
T
F
G
---
G
---
I
N
L
E
D
I
S
A
P
R
C
F
E
I
E
Q
R
L
I
K
E
-
C
H
I
P
V
F
H
D
D
Q
H
G
T
A
I
V
V
L
A
A
I
F
N
S
L
K
L
L
K
K
S
L
D
E
V
S
I
V
V
N
G
G
G
S
A
G
L
S
I
T
R
K
L
L
A
A
----------
G
----------
A
--
T
--
K
V
T
V
V
D
K
F
G
-----
I
I
N
E
Q
E
A
A
--
Q
-
L
A
P
---
D
I
A
K
V
----
T
N
-----
R
E
F
K
S
G
T
L
E
D
A
L
E
--
G
A
D
--
I
F
I
G
V
S
--
A
--
P
G
-
V
L
K
A
E
W
I
S
K
-
M
A
---
A
---
R
P
V
I
F
A
M
A
N
P
I
P
--
E
I
Y
P
D
E
A
--
L
E
--
A
G
A
Y
I
V
G
T
-----------
G
R
-----------
S
D
F
P
N
-----------
Q
I
N
N
V
L
A
F
P
G
I
F
R
G
A
L
D
A
R
A
K
T
I
T
V
E
M
Q
I
A
A
A
K
G
I
A
-
S
L
V
P
D
D
A
L
S
T
T
N
I
I
-----
P
--
D
A
F
K
E
-
G
V
A
E
I
V
A
K
S
V
R
S
----
51
Fugue
85.81
77%
-103
- C5 -
2A9F
1
?
A:
[3-388]
L
K
N
Q
L
G
Q
L
A
L
E
Q
A
K
T
---
F
G
G
K
L
E
V
Q
P
K
V
D
I
K
T
-
K
H
D
L
S
I
A
Y
T
P
G
V
A
S
V
S
S
A
I
A
-------------
K
D
K
T
L
A
Y
D
L
T
--
T
K
--
K
N
T
V
A
V
I
S
D
G
T
A
V
L
G
L
G
D
I
G
P
E
A
-
A
M
P
V
M
E
G
K
A
A
L
F
K
A
F
A
G
V
---
D
---
A
I
P
I
V
L
-----------------------
D
T
------
K
------
D
T
E
E
I
I
------------------------
S
-----------------------
I
V
K
A
L
A
P
T
F
G
---
G
---
I
N
L
E
D
I
S
A
P
R
C
F
E
I
E
Q
R
L
I
K
E
-
C
H
I
P
V
F
H
D
D
Q
H
G
T
A
I
V
V
L
A
A
I
F
N
S
L
K
L
L
K
K
S
L
D
E
V
S
I
V
V
N
G
G
G
S
A
G
L
S
I
T
R
K
L
L
A
A
----------
G
----------
A
--
T
--
K
V
T
V
V
D
K
F
G
-----
I
I
N
E
Q
E
A
A
--
Q
-
L
A
P
D
I
A
K
V
T
-------
N
-----
R
E
F
K
S
G
T
L
E
D
A
L
E
--
G
A
D
--
I
F
I
G
V
S
--
A
--
P
G
-
V
L
K
A
E
W
I
S
K
-
M
A
---
A
---
R
P
V
I
F
A
M
A
N
P
I
P
--
E
I
Y
P
D
E
A
--
L
E
--
A
G
A
Y
I
V
G
T
-----------
G
R
-----------
S
D
F
P
N
-----------
Q
I
N
N
V
L
A
F
P
G
I
F
R
G
A
L
D
A
R
A
K
T
I
T
V
E
M
Q
I
A
A
A
K
G
I
A
-
S
L
V
P
D
D
A
L
S
T
T
N
I
I
-----
P
--
D
A
F
K
E
-
G
V
A
E
I
V
A
K
S
V
R
S
V
V
L
-
27
PsiBlast_CBE
85.28
53%
-106
- C5 -
2DVM
2
?
B:
[18-394]
--------------------
G
K
I
E
V
I
P
K
V
S
L
E
S
-
R
E
E
L
T
L
A
Y
T
P
G
V
A
E
P
C
K
E
I
A
-------------
R
D
P
G
K
V
Y
E
Y
T
--
S
K
--
G
N
L
V
A
V
V
S
D
G
S
R
I
L
G
L
G
N
I
G
P
L
A
-
G
L
P
V
M
E
G
K
A
L
L
F
K
R
F
G
G
V
---
D
---
A
F
P
I
M
I
-----------------------
K
E
------
Q
------
E
P
N
K
F
I
------------------------
D
-----------------------
I
V
K
A
I
A
P
T
F
G
---
G
---
I
N
L
E
D
I
A
S
P
K
C
F
Y
I
L
E
R
L
R
E
E
-
L
D
I
P
V
F
H
D
D
Q
Q
G
T
A
A
V
V
L
A
G
L
L
N
A
L
K
V
V
G
K
K
I
S
E
I
T
L
A
L
F
G
A
G
A
A
G
F
A
T
L
R
I
L
T
E
A
----------
G
----------
V
--
K
PE
N
V
R
V
V
E
L
V
N
GKPRI
L
T
S
D
L
D
L
E
--
K
-
L
F
P
Y
R
G
W
L
L
K
K
----
T
N
-----
G
E
N
I
E
G
G
P
Q
E
A
L
K
--
D
A
D
--
V
L
I
S
F
T
RP
G
--
P
G
-
V
I
K
P
Q
W
I
E
K
-
M
N
---
E
---
D
A
I
V
F
P
L
A
N
P
V
P
--
E
I
L
P
E
E
A
--
K
K
--
A
G
A
R
I
V
A
T
-----------
G
R
-----------
S
D
Y
P
N
-----------
Q
I
N
N
L
L
G
F
P
G
I
F
R
G
A
L
D
V
R
A
R
T
I
T
D
S
M
I
I
A
A
A
K
A
I
A
-
S
I
V
--
E
E
P
S
E
E
N
I
I
-----
P
--
S
P
L
N
P
-
I
V
Y
A
R
E
A
R
A
V
A
E
E
A
M
K
25
PsiBlast_CBE
84.86
53%
-108
- C5 -
2DVM
2
?
D:
[18-394]
--------------------
G
K
I
E
V
I
P
K
V
S
L
E
S
-
R
E
E
L
T
L
A
Y
T
P
G
V
A
E
P
C
K
E
I
A
-------------
R
D
P
G
K
V
Y
E
Y
T
--
S
K
--
G
N
L
V
A
V
V
S
D
G
S
R
I
L
G
L
G
N
I
G
P
L
A
-
G
L
P
V
M
E
G
K
A
L
L
F
K
R
F
G
G
V
---
D
---
A
F
P
I
M
I
-----------------------
K
E
------
Q
------
E
P
N
K
F
I
------------------------
D
-----------------------
I
V
K
A
I
A
P
T
F
G
---
G
---
I
N
L
E
D
I
A
S
P
K
C
F
Y
I
L
E
R
L
R
E
E
-
L
D
I
P
V
F
H
D
D
Q
Q
G
T
A
A
V
V
L
A
G
L
L
N
A
L
K
V
V
G
K
K
I
S
E
I
T
L
A
L
F
G
A
G
A
A
G
F
A
T
L
R
I
L
T
E
A
----------
G
----------
V
--
K
PE
N
V
R
V
V
E
L
V
N
GKPRI
L
T
S
D
L
D
L
E
--
K
-
L
F
P
Y
R
G
W
L
L
K
K
----
T
N
-----
G
E
N
I
E
G
G
P
Q
E
A
L
K
--
D
A
D
--
V
L
I
S
F
T
RP
G
--
P
G
-
V
I
K
P
Q
W
I
E
K
-
M
N
---
E
---
D
A
I
V
F
P
L
A
N
P
V
P
--
E
I
L
P
E
E
A
--
K
K
--
A
G
A
R
I
V
A
T
-----------
G
R
-----------
S
D
Y
P
N
-----------
Q
I
N
N
L
L
G
F
P
G
I
F
R
G
A
L
D
V
R
A
R
T
I
T
D
S
M
I
I
A
A
A
K
A
I
A
-
S
I
V
--
E
E
P
S
E
E
N
I
I
-----
P
--
S
P
L
N
P
-
I
V
Y
A
R
E
A
R
A
V
A
E
E
A
M
K
4
PsiBlast_PDB
84.01
53%
-106
- C5 -
2DVM
3
?
A:
[18-394]
--------------------
G
K
I
E
V
I
P
K
V
S
L
E
S
-
R
E
E
L
T
L
A
Y
T
P
G
V
A
E
P
C
K
E
I
A
-------------
R
D
P
G
K
V
Y
E
Y
T
--
S
K
--
G
N
L
V
A
V
V
S
D
G
S
R
I
L
G
L
G
N
I
G
P
L
A
-
G
L
P
V
M
E
G
K
A
L
L
F
K
R
F
G
G
V
---
D
---
A
F
P
I
M
I
-----------------------
K
E
------
Q
------
E
P
N
K
F
I
------------------------
D
-----------------------
I
V
K
A
I
A
P
T
F
G
---
G
---
I
N
L
E
D
I
A
S
P
K
C
F
Y
I
L
E
R
L
R
E
E
-
L
D
I
P
V
F
H
D
D
Q
Q
G
T
A
A
V
V
L
A
G
L
L
N
A
L
K
V
V
G
K
K
I
S
E
I
T
L
A
L
F
G
A
G
A
A
G
F
A
T
L
R
I
L
T
E
A
----------
G
----------
V
--
K
PE
N
V
R
V
V
E
L
V
N
G
K
P
R
I
L
T
S
D
L
D
L
E
--
K
-
L
F
P
Y
R
G
W
L
L
K
K
----
T
N
-----
G
E
N
I
E
G
G
P
Q
E
A
L
K
--
D
A
D
--
V
L
I
S
F
T
RP
G
--
P
G
-
V
I
K
P
Q
W
I
E
K
-
M
N
---
E
---
D
A
I
V
F
P
L
A
N
P
V
P
--
E
I
L
P
E
E
A
--
K
K
--
A
G
A
R
I
V
A
T
-----------
G
R
-----------
S
D
Y
P
N
-----------
Q
I
N
N
L
L
G
F
P
G
I
F
R
G
A
L
D
V
R
A
R
T
I
T
D
S
M
I
I
A
A
A
K
A
I
A
-
S
I
V
--
E
E
P
S
E
E
N
I
I
-----
P
--
S
P
L
N
P
-
I
V
Y
A
R
E
A
R
A
V
A
E
E
A
M
K
24
PsiBlast_CBE
81.95
58%
-106
- C5 -
2HAE
1
?
B:
[14-366]
--------------------
G
K
I
R
T
A
L
P
V
E
K
V
D
-
R
E
T
L
S
L
L
Y
T
P
G
V
A
D
V
A
R
A
C
A
-------------
E
D
P
E
K
T
Y
V
Y
T
--
S
R
--
W
N
T
V
A
V
V
S
D
G
S
A
V
L
G
L
G
N
I
G
P
Y
G
-
A
L
P
V
M
E
G
K
A
F
L
F
K
A
F
A
D
I
---
D
---
A
F
P
I
C
L
-----------------------
S
E
------
S
------
E
E
E
K
I
I
------------------------
S
-----------------------
I
V
K
S
L
E
P
S
F
G
---
G
---
I
N
L
E
D
I
G
A
P
K
C
F
R
I
L
Q
R
L
S
E
E
-
M
N
I
P
V
F
H
D
D
Q
Q
G
T
A
V
V
V
S
A
A
F
L
N
A
L
K
L
T
E
K
K
I
E
E
V
K
V
V
V
N
G
I
G
A
A
G
Y
N
I
V
K
F
L
L
D
L
----------
G
----------
V
--
K
--
N
V
V
A
V
D
R
K
G
-----
I
L
N
E
N
D
P
E
--
T
C
L
N
E
Y
--
E
I
A
R
I
----
T
N
-----
P
E
R
L
S
G
D
L
E
T
A
L
E
--
G
A
D
--
F
F
I
G
V
S
--
R
--
G
N
-
I
L
K
P
E
W
I
K
K
-
M
S
---
R
---
K
P
V
I
F
A
L
A
N
P
V
P
--
E
I
D
P
E
L
A
--
R
E
--
A
G
A
F
I
V
A
T
-----------
G
R
-----------
S
D
H
P
N
-----------
Q
V
N
N
L
L
A
F
P
G
I
M
K
G
A
V
E
K
R
S
K
-
I
T
K
N
M
L
L
S
A
V
E
A
I
A
R
S
C
E
P
E
P
E
----
R
I
I
-----
P
--
E
A
F
D
M
-
K
V
H
L
N
V
Y
T
A
V
K
G
S
A
--
2
PsiBlast_PDB
81.69
58%
-106
- C5 -
2HAE
1
?
A:
[14-366]
--------------------
G
K
I
R
T
A
L
P
V
E
K
V
D
-
R
E
T
L
S
L
L
Y
T
P
G
V
A
D
V
A
R
A
C
A
-------------
E
D
P
E
K
T
Y
V
Y
T
--
S
R
--
W
N
T
V
A
V
V
S
D
G
S
A
V
L
G
L
G
N
I
G
P
Y
G
-
A
L
P
V
M
E
G
K
A
F
L
F
K
A
F
A
D
I
---
D
---
A
F
P
I
C
L
-----------------------
S
E
------
S
------
E
E
E
K
I
I
------------------------
S
-----------------------
I
V
K
S
L
E
P
S
F
G
---
G
---
I
N
L
E
D
I
G
A
P
K
C
F
R
I
L
Q
R
L
S
E
E
-
M
N
I
P
V
F
H
D
D
Q
Q
G
T
A
V
V
V
S
A
A
F
L
N
A
L
K
L
T
E
K
K
I
E
E
V
K
V
V
V
N
G
I
G
A
A
G
Y
N
I
V
K
F
L
L
D
L
----------
G
----------
V
--
K
--
N
V
V
A
V
D
R
K
G
-----
I
L
N
E
N
D
P
E
--
T
C
L
N
E
Y
--
E
I
A
R
I
----
T
N
-----
P
E
R
L
S
G
D
L
E
T
A
L
E
--
G
A
D
--
F
F
I
G
V
S
--
R
--
G
N
-
I
L
K
P
E
W
I
K
K
-
M
S
---
R
---
K
P
V
I
F
A
L
A
N
P
V
P
--
E
I
D
P
E
L
A
--
R
E
--
A
G
A
F
I
V
A
T
-----------
G
R
-----------
S
D
H
P
N
-----------
Q
V
N
N
L
L
A
F
P
G
I
M
K
G
A
V
E
K
R
S
K
-
I
T
K
N
M
L
L
S
A
V
E
A
I
A
R
S
C
E
P
E
P
E
----
R
I
I
-----
P
--
E
A
F
D
M
-
K
V
H
L
N
V
Y
T
A
V
K
G
S
A
--
22
PsiBlast_CBE
81.29
58%
-104
- C5 -
2HAE
1
?
D:
[14-366]
--------------------
G
K
I
R
T
A
L
P
V
E
K
V
D
-
R
E
T
L
S
L
L
Y
T
P
G
V
A
D
V
A
R
A
C
A
-------------
E
D
P
E
K
T
Y
V
Y
T
--
S
R
--
W
N
T
V
A
V
V
S
D
G
S
A
V
L
G
L
G
N
I
G
P
Y
G
-
A
L
P
V
M
E
G
K
A
F
L
F
K
A
F
A
D
I
---
D
---
A
F
P
I
C
L
-----------------------
S
E
------
S
------
E
E
E
K
I
I
------------------------
S
-----------------------
I
V
K
S
L
E
P
S
F
G
---
G
---
I
N
L
E
D
I
G
A
P
K
C
F
R
I
L
Q
R
L
S
E
E
-
M
N
I
P
V
F
H
D
D
Q
Q
G
T
A
V
V
V
S
A
A
F
L
N
A
L
K
L
T
E
K
K
I
E
E
V
K
V
V
V
N
G
I
G
A
A
G
Y
N
I
V
K
F
L
L
D
L
----------
G
----------
V
--
K
--
N
V
V
A
V
D
R
K
G
-----
I
L
N
E
N
D
P
E
--
T
C
L
N
E
Y
--
E
I
A
R
I
----
T
N
-----
P
E
R
L
S
G
D
L
E
T
A
L
E
--
G
A
D
--
F
F
I
G
V
S
--
R
--
G
N
-
I
L
K
P
E
W
I
K
K
-
M
S
---
R
---
K
P
V
I
F
A
L
A
N
P
V
P
--
E
I
D
P
E
L
A
--
R
E
--
A
G
A
F
I
V
A
T
-----------
G
R
-----------
S
D
H
P
N
-----------
Q
V
N
N
L
L
A
F
P
G
I
M
K
G
A
V
E
K
R
S
K
-
I
T
K
N
M
L
L
S
A
V
E
A
I
A
R
S
C
E
P
E
P
E
----
R
I
I
-----
P
--
E
A
F
D
M
-
K
V
H
L
N
V
Y
T
A
V
K
G
S
A
--
29
HHSearch
80.61
52%
-99
- C5 -
2DVM
3
?
A:
[2-394]
----
I
R
E
K
A
L
E
F
H
K
N
NFP
G
N
G
K
I
E
V
I
P
K
V
S
L
E
S
-
R
E
E
L
T
L
A
Y
T
P
G
V
A
E
P
C
K
E
I
A
-------------
R
D
P
G
K
V
Y
E
Y
T
--
S
K
--
G
N
L
V
A
V
V
S
D
G
S
R
I
L
G
L
G
N
I
G
P
L
A
-
G
L
P
V
M
E
G
K
A
L
L
F
K
R
F
G
G
V
---
D
---
A
F
P
I
M
I
-----------------------
K
E
------
Q
------
E
P
N
K
F
I
------------------------
D
-----------------------
I
V
K
A
I
A
P
T
F
G
---
G
---
I
N
L
E
D
I
A
S
P
K
C
F
Y
I
L
E
R
L
R
E
E
-
L
D
I
P
V
F
H
D
D
Q
Q
G
T
A
A
V
V
L
A
G
L
L
N
A
L
K
V
V
G
K
K
I
S
E
I
T
L
A
L
F
G
A
G
A
A
G
F
A
T
L
R
I
L
T
E
A
----------
G
VKPEN-----
V
--
R
--
V
V
E
L
V
N
G
K
P
-----
R
I
L
T
S
D
L
D
L
E
K
-
L
F
P
Y
R
G
W
L
L
K
K
----
T
N
-----
G
E
N
I
E
G
G
P
Q
E
A
L
K
--
D
A
D
--
V
L
I
S
F
T
--
R
PG
P
G
-
V
I
K
P
Q
W
I
E
K
-
M
N
---
E
---
D
A
I
V
F
P
L
A
N
P
V
P
--
E
I
L
P
E
E
A
--
K
K
--
A
G
A
R
I
V
A
T
-----------
G
R
-----------
S
D
Y
P
N
-----------
Q
I
N
N
L
L
G
F
P
G
I
F
R
G
A
L
D
V
R
A
R
T
I
T
D
S
M
I
I
A
A
A
K
A
I
A
-
S
I
V
E
E
P
--
S
E
E
N
I
I
-----
P
--
S
P
L
N
P
-
I
V
Y
A
R
E
A
R
A
V
A
E
E
A
M
K
23
PsiBlast_CBE
79.91
58%
-106
- C5 -
2HAE
1
?
C:
[14-366]
--------------------
G
K
I
R
T
A
L
P
V
E
K
V
D
-
R
E
T
L
S
L
L
Y
T
P
G
V
A
D
V
A
R
A
C
A
-------------
E
D
P
E
K
T
Y
V
Y
T
--
S
R
--
W
N
T
V
A
V
V
S
D
G
S
A
V
L
G
L
G
N
I
G
P
Y
G
-
A
L
P
V
M
E
G
K
A
F
L
F
K
A
F
A
D
I
---
D
---
A
F
P
I
C
L
-----------------------
S
E
------
S
------
E
E
E
K
I
I
------------------------
S
-----------------------
I
V
K
S
L
E
P
S
F
G
---
G
---
I
N
L
E
D
I
G
A
P
K
C
F
R
I
L
Q
R
L
S
E
E
-
M
N
I
P
V
F
H
D
D
Q
Q
G
T
A
V
V
V
S
A
A
F
L
N
A
L
K
L
T
E
K
K
I
E
E
V
K
V
V
V
N
G
I
G
A
A
G
Y
N
I
V
K
F
L
L
D
L
----------
G
----------
V
--
K
--
N
V
V
A
V
D
R
K
G
-----
I
L
N
E
N
D
P
E
--
T
C
L
N
E
Y
--
E
I
A
R
I
----
T
N
-----
P
E
R
L
S
G
D
L
E
T
A
L
E
--
G
A
D
--
F
F
I
G
V
S
--
R
--
G
N
-
I
L
K
P
E
W
I
K
K
-
M
S
---
R
---
K
P
V
I
F
A
L
A
N
P
V
P
--
E
I
D
P
E
L
A
--
R
E
--
A
G
A
F
I
V
A
T
-----------
G
R
-----------
S
D
H
P
N
-----------
Q
V
N
N
L
L
A
F
P
G
I
M
K
G
A
V
E
K
R
S
K
-
I
T
K
N
M
L
L
S
A
V
E
A
I
A
R
S
C
E
P
E
P
E
----
R
I
I
-----
P
--
E
A
F
D
M
-
K
V
H
L
N
V
Y
T
A
V
K
G
S
A
--
6
PsiBlast_PDB
78.11
42%
-101
- C5 -
3NV9
13
?
A:
[45-432]
--------------------
G
K
I
Q
I
M
P
K
C
T
L
A
G
-
F
N
W
F
N
A
Y
Y
T
P
G
V
S
R
I
S
T
N
I
R
-------------
D
N
N
D
S
S
L
F
Y
S
--
L
R
--
G
N
F
V
G
V
V
S
D
S
T
R
V
L
G
D
G
D
V
T
P
P
G
-
G
L
G
V
M
E
G
K
A
L
L
M
K
Y
L
G
G
I
---
D
---
A
V
P
I
C
I
-----------------------
D
S
KNKEGK
N
------
D
P
D
A
V
I
------------------------
E
-----------------------
F
V
Q
R
I
Q
H
T
F
G
---
A
---
I
N
L
E
D
I
S
Q
P
N
C
Y
K
I
L
D
V
L
R
E
S
-
C
D
I
P
V
W
H
D
D
Q
Q
G
T
A
S
V
T
L
A
G
L
L
N
A
L
K
L
V
K
K
D
I
H
E
C
R
M
V
F
I
G
A
G
S
S
N
T
T
C
L
R
L
I
V
T
A
----------
G
----------
A
DP
K
--
K
I
V
M
F
D
S
K
G
-----
S
L
H
N
-
G
R
E
--
D
-
I
K
K
D
T
R
F
Y
R
K
W
E
I
C
E
T
T
-----
N
P
S
K
F
G
S
I
A
E
A
C
V
--
G
A
D
--
V
L
I
S
L
S
TP
G
--
P
G
-
V
V
K
A
E
W
I
K
S
-
M
G
---
E
---
K
P
I
V
F
C
C
A
N
P
V
P
--
E
I
Y
P
Y
E
A
--
K
E
--
A
G
A
Y
I
V
A
T
-----------
G
R
-----------
G
D
F
P
N
-----------
Q
V
N
N
S
V
G
F
P
G
I
L
K
G
A
L
I
V
R
A
R
K
I
T
D
N
M
A
I
A
A
S
R
A
L
A
-
E
F
A
E
K
R
G
I
N
P
D
N
I
I
GTMDE
P
--
G
I
F
P
K
-
E
A
A
D
V
A
M
Q
A
I
K
D
G
V
A
R
30
HHSearch
78.09
41%
-103
- C5 -
3NV9
14
?
A:
[30-427]
--
Q
F
Y
K
E
L
A
E
K
V
H
K
F
---
Y
K
G
K
I
Q
I
M
P
K
C
T
L
A
G
-
F
N
W
F
N
A
Y
Y
T
P
G
V
S
R
I
S
T
N
I
R
-------------
D
N
N
D
S
S
L
F
Y
S
--
L
R
--
G
N
F
V
G
V
V
S
D
S
T
R
V
L
G
D
G
D
V
T
P
P
G
-
G
L
G
V
M
E
G
K
A
L
L
M
K
Y
L
G
G
I
---
D
---
A
V
P
I
C
I
-----------------------
D
S
------
K
NKEGKN
D
P
D
A
V
I
------------------------
E
-----------------------
F
V
Q
R
I
Q
H
T
F
G
---
A
---
I
N
L
E
D
I
S
Q
P
N
C
Y
K
I
L
D
V
L
R
E
S
-
C
D
I
P
V
W
H
D
D
Q
Q
G
T
A
S
V
T
L
A
G
L
L
N
A
L
K
L
V
K
K
D
I
H
E
C
R
M
V
F
I
G
A
G
S
S
N
T
T
C
L
R
L
I
V
T
A
----------
G
AD--------
P
--
K
--
K
I
V
M
F
D
S
K
G
-----
S
L
H
N
G
R
E
D
----
I
K
K
-
D
T
R
F
Y
R
K
----
W
E
I
C
E
T
T
N
P
S
K
F
G
S
I
A
E
A
C
V
--
G
A
D
--
V
L
I
S
L
S
--
T
PG
P
G
-
V
V
K
A
E
W
I
K
S
-
M
G
---
E
---
K
P
I
V
F
C
C
A
N
P
V
P
--
E
I
Y
P
Y
E
A
--
K
E
--
A
G
A
Y
I
V
A
T
-----------
G
R
-----------
G
D
F
P
N
-----------
Q
V
N
N
S
V
G
F
P
G
I
L
K
G
A
L
I
V
R
A
R
K
I
T
D
N
M
A
I
A
A
S
R
A
L
A
-
E
F
A
E
K
R
G
I
N
P
D
N
I
I
-----
G
--
T
M
D
E
P
-
G
I
F
P
K
E
A
A
D
V
A
M
Q
A
I
K
28
PsiBlast_CBE
78.00
42%
-100
- C5 -
3NV9
13
?
B:
[45-432]
--------------------
G
K
I
Q
I
M
P
K
C
T
L
A
G
-
F
N
W
F
N
A
Y
Y
T
P
G
V
S
R
I
S
T
N
I
R
-------------
D
N
N
D
S
S
L
F
Y
S
--
L
R
--
G
N
F
V
G
V
V
S
D
S
T
R
V
L
G
D
G
D
V
T
P
P
G
-
G
L
G
V
M
E
G
K
A
L
L
M
K
Y
L
G
G
I
---
D
---
A
V
P
I
C
I
-----------------------
D
S
KNKEGK
N
------
D
P
D
A
V
I
------------------------
E
-----------------------
F
V
Q
R
I
Q
H
T
F
G
---
A
---
I
N
L
E
D
I
S
Q
P
N
C
Y
K
I
L
D
V
L
R
E
S
-
C
D
I
P
V
W
H
D
D
Q
Q
G
T
A
S
V
T
L
A
G
L
L
N
A
L
K
L
V
K
K
D
I
H
E
C
R
M
V
F
I
G
A
G
S
S
N
T
T
C
L
R
L
I
V
T
A
----------
G
----------
A
DP
K
--
K
I
V
M
F
D
S
K
G
-----
S
L
H
N
-
G
R
E
--
D
-
I
K
K
D
T
R
F
Y
R
K
W
EICE
T
T
-----
N
P
S
K
F
G
S
I
A
E
A
C
V
--
G
A
D
--
V
L
I
S
L
S
TP
G
--
P
G
-
V
V
K
A
E
W
I
K
S
-
M
G
---
E
---
K
P
I
V
F
C
C
A
N
P
V
P
--
E
I
Y
P
Y
E
A
--
K
E
--
A
G
A
Y
I
V
A
T
-----------
G
R
-----------
G
D
F
P
N
-----------
Q
V
N
N
S
V
G
F
P
G
I
L
K
G
A
L
I
V
R
A
R
K
I
T
D
N
M
A
I
A
A
S
R
A
L
A
-
E
F
A
E
K
R
G
I
N
P
D
N
I
I
GTMDE
P
--
G
I
F
P
K
-
E
A
A
D
V
A
M
Q
A
I
K
D
G
V
A
R
8
PsiBlast_PDB
65.38
25%
-105
- C5 -
2AW5
-
MAOX_HUMAN
A:
[133-524]
---------------------------------------------
I
A
S
V
L
N
A
W
P
-------------
E
D
V
I
K
A
--------------
I
V
V
T
D
G
E
R
I
L
G
L
G
D
L
G
C
N
G
--
M
G
I
P
V
G
K
L
A
L
Y
T
A
C
G
G
M
NPQ
E
---
C
L
P
V
I
L
-----------------------
D
V
G-----
T
------
E
N
E
E
L
L
------------------------
K
DPLYIGLRQRRVRG
S
E
Y
D
D
F
L
D
E
F
M
E
A
V
S
S
K
Y
G
---
M
N
C
L
I
Q
F
E
D
F
A
N
V
N
A
F
R
L
L
N
K
Y
R
N
Q
Y
C
---
T
F
N
D
D
I
Q
G
T
A
S
V
A
V
A
G
L
L
A
A
L
R
I
T
K
N
K
L
S
D
Q
T
I
L
F
Q
G
A
G
E
A
A
L
G
I
A
H
L
I
V
M
A
L
E
K
E
GLP
K
E
K
A
----------
I
--
K
--
K
I
W
L
V
D
S
K
G
-----
L
I
V
-
K
G
--------
Q
E
K
E
---
K
F
----
A
H
-----
E
H
E
E
M
K
N
L
E
A
I
V
Q
E
I
K
P
T
--
A
L
I
G
V
A
--
A
--
I
G
-
G
A
F
S
E
Q
I
L
K
D
M
A
A
F
N
E
---
R
P
I
I
F
A
L
S
N
P
T
S
KA
E
C
S
A
E
Q
C
--
Y
K
I
T
K
G
R
A
I
F
A
S
G
S
P
F
D
PVTLPN
G
Q
-----------
T
L
Y
P
G
-----------
Q
G
N
N
S
Y
V
F
P
G
V
A
L
G
V
V
A
C
G
L
R
Q
I
T
D
N
I
F
L
T
T
A
E
V
I
A
-
Q
Q
V
S
D
K
H
L
E
E
G
R
L
Y
-----
P
PL
N
T
I
R
D
-
V
S
L
K
I
A
E
K
I
V
K
D
A
Y
Q
E
32
HHSearch
63.52
29%
-90
- C5 -
1GQ2
3
MAOX_COLLI
A:
[70-511]
---------------------
N
E
K
L
F
Y
K
V
L
T
S
D
I
E
R
F
M
P
I
V
Y
T
P
T
V
G
L
A
C
Q
H
Y
G
LAFRRPR
G
L
F
I
T
I
H
D
R
G
H
I
A
T
M
L
Q
S
W
P
ES
V
I
K
A
I
V
V
T
D
G
E
R
I
L
G
L
G
D
L
G
C
Y
--
G
M
G
I
P
V
G
K
L
A
L
Y
T
A
C
G
G
V
---
K
PHQ
C
L
P
V
M
L
-----------------------
D
V
------
G
------
T
D
N
E
T
L
L
K
DPLYIGLRH
K
R
I
R
G
Q
A
Y
D
D
L
L
D
E
-----------------------
F
M
E
A
V
T
S
R
Y
G
MN
C
L
---
I
Q
F
E
D
F
A
N
A
N
A
F
R
L
L
H
K
Y
R
N
K
---
Y
C
T
F
N
D
D
I
Q
G
T
A
S
V
A
V
A
G
L
L
A
A
L
R
I
T
K
N
R
L
S
D
H
T
V
L
F
Q
G
A
G
E
A
A
L
G
I
A
N
L
I
V
M
A
----------
M
Q
K
E
GVS
K
E
E
A
I
--
K
--
R
I
W
M
V
D
S
K
G
-----
L
I
V
K
G
R
A
S
----
L
T
P
E
K
E
H
F
A
H
E
----
H
C
--------
E
M
K
N
L
E
D
I
V
K
D
I
K
P
T
--
V
L
I
G
V
A
--
A
I-
G
G
-
A
F
T
Q
Q
I
L
Q
D
-
M
A
A
FN
K
---
R
P
I
I
F
A
L
S
N
P
T
S
KA
E
C
T
A
E
Q
L
--
Y
K
Y
T
E
G
R
G
I
F
A
S
-----------
G
S
P
F
D
P
VTLPSG
Q
T
L
Y
P
G
-----------
Q
G
N
N
S
Y
V
F
P
G
V
A
L
G
V
I
S
C
G
L
K
H
I
G
D
D
V
F
L
T
T
A
E
V
I
A
-
Q
E
V
S
E
E
N
L
Q
E
G
R
L
Y
-----
P
--
P
L
V
T
I
Q
Q
V
S
L
K
I
A
V
R
I
A
K
E
A
Y
R
10
PsiBlast_PDB
62.59
24%
-119
- C5 -
1O0S
1
MAOM_ASCSU
A:
[175-526]
----------------------------------------------------------------------------------------
V
V
T
D
G
E
R
I
L
G
L
G
D
L
G
A
Y
G
I
G
I
P
V
--
G
K
L
A
L
Y
V
A
L
G
G
V
---
Q
PKW
C
L
P
V
L
L
D
VGTNN
M
D
L
L
N
DPFYIGLRH
K
R
V
R
G
------
K
------
D
Y
D
T
L
L
D
-----------------------
N
-----------------------
F
M
K
A
C
T
K
K
Y
G
---
Q
K
T
L
I
Q
F
E
D
F
A
N
P
N
A
F
R
L
L
D
K
Y
Q
D
K
---
Y
T
M
F
N
D
D
I
Q
G
T
A
S
V
I
V
A
G
L
L
T
C
T
R
V
T
K
K
L
V
S
Q
E
K
Y
L
F
F
G
A
G
A
A
S
T
G
I
A
E
M
I
V
H
Q
M
Q
N
E
GIS
K
E
E
A
----------
C
--
N
--
R
I
Y
L
M
D
I
D
G
-----
L
V
T
-
K
N
R
K
--
E
-
M
N
P
R
H
V
Q
F
A
K
D
----
M
P
--------
E
T
T
S
I
L
E
V
I
R
--
A
A
R
PG
A
L
I
G
A
S
--
T
--
V
R
G
A
F
N
E
E
V
I
R
A
-
M
A
---
E
I
N
E
R
P
I
I
F
A
L
S
N
P
T
S
KA
E
C
T
A
E
E
A
Y
T
F
T
--
N
G
A
A
L
Y
A
S
-----------
G
------------
S
P
F
P
N
FELNG
H
T
Y
K
P
G
Q
G
N
N
A
Y
I
F
P
G
V
A
L
G
T
I
L
F
Q
I
R
H
V
D
N
D
L
F
L
L
A
A
K
K
V
A
-
S
C
V
T
E
D
S
L
K
V
G
R
V
Y
-----
P
--
Q
L
K
E
I
-
R
E
I
S
I
Q
I
A
V
E
M
A
K
Y
C
Y
9
PsiBlast_PDB
61.26
24%
-114
- C5 -
1LLQ
1
MAOM_ASCSU
A:
[175-526]
----------------------------------------------------------------------------------------
V
V
T
D
G
E
R
I
L
G
L
G
D
L
G
A
Y
G
I
G
I
P
V
--
G
K
L
A
L
Y
V
A
L
G
G
V
---
Q
PKW
C
L
P
V
L
L
D
VGTNN
M
D
L
L
N
DPFYIGLRHKRV
R
G
------
K
------
D
Y
D
T
L
L
D
-----------------------
N
-----------------------
F
M
K
A
C
T
K
K
Y
G
---
Q
K
T
L
I
Q
F
E
D
F
A
N
P
N
A
F
R
L
L
D
K
Y
Q
D
K
---
Y
T
M
F
N
D
D
I
Q
G
T
A
S
V
I
V
A
G
L
L
T
C
T
R
V
T
K
K
L
V
S
Q
E
K
Y
L
F
F
G
A
G
A
A
S
T
G
I
A
E
M
I
V
H
Q
M
Q
N
E
GISKEE
A
----------
C
--
N
--
R
I
Y
L
M
D
I
D
G
-----
L
V
T
-
K
N
R
K
--
E
-
M
N
P
R
H
V
Q
F
A
K
D
----
M
P
--------
E
T
T
S
I
L
E
V
I
R
--
A
A
R
PG
A
L
I
G
A
S
--
T
--
V
R
G
A
F
N
E
E
V
I
R
A
-
M
A
---
E
I
N
E
R
P
I
I
F
A
L
S
N
P
T
S
KA
E
C
T
A
E
E
A
Y
T
F
T
--
N
G
A
A
L
Y
A
S
-----------
G
------------
S
P
F
P
N
FELNG
H
T
Y
K
P
G
Q
G
N
N
A
Y
I
F
P
G
V
A
L
G
T
I
L
F
Q
I
R
H
V
D
N
D
L
F
L
L
A
A
K
K
V
A
-
S
C
V
T
E
D
S
L
K
V
G
R
V
Y
-----
P
--
Q
L
K
E
I
-
R
E
I
S
I
Q
I
A
V
E
M
A
K
Y
C
Y