@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs2109: (2015-12-13 )
MGIEFKNVSYTYQAGTPFEGRALFDVNLKIEDASYTAFIGHTGSGKSTIMQLLNGLHIPTKGEVIVDDFSIKAGDKNKEIKFIRQKVGLVFQFPESQLFEETVLKDVAFGPQNFGISQIEAERLAEEKLRLVGISEDLFDKNPFELSGGQMRRVAIAGILAMEPKVLVLDEPTAGLDPKGRKELMTLFKNLHKKGMTIVLVTHLMDDVADYADYVYVLEAGKVTLSGQPKQIFQEVELLESKQLGVPKITKFAQRLSHKGLNLPSLPITINEFVEAIKHG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70.....---------...80........90.-.......-100........110..----.....120.......130.......-140.......150.......160.......170.......180.......190.-.-.....200.......210.......220.......230.-----......240.......250.......260.......270.......280--------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
G
I
E
FKN
V
S
Y
T
YQAGTPFE
G
R
A
L
F
D
V
N
L
K
I
EDA
S
Y
T
A
F
I
GHTGS
G
K
S
T
I
M
Q
L
L
NGLHIPTKG
E
V
I
V
D
D
F
S
IKAGDK---------N
K
E
I
K
F
I
R
Q
KV
G
L
V
F
Q-F
P
E
S
Q
L
F
-
E
-
E
T
V
L
K
D
VAFGPQNF----G
I
S
Q
I
E
A
E
R
L
A
E
E
K
L
R
L
VGI
S
E
D
L
F-DKNPFELSGG
Q
M
R
R
V
A
I
A
G
I
LAME
P
K
V
L
V
L
DEPTAGLDP
K
G
R
K
E
L
M
T
L
F
K
N
L
H
K-K-G
M
T
I
V
L
V
T
H
L
M
D
D
V
A
D
YA
D
Y
V
Y
V
L
EA
G
K
V
T
LSG
Q
P
K
Q
I
F
-----
Q
E
V
E
L
L
E
SKQLG
V
P
K
I
T
K
F
A
Q
R
L
S
HKGLNLPSLPI
T
I
N
E
F
V
E
A
I
KHG----------------------------------------------------------
1
PsiBlast_PDB
94.27
54%
-108
- C1 -
4HUQ
-
ECFA2_LACBA
A:
[2-276]
-
A
I
A
F
E
H
V
T
Y
T
Y
Q
A
G
T
P
M
A
H
T
A
L
T
D
V
S
L
T
V
P
D
R
G
Y
L
A
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
A
L
L
K
P
T
S
G
T
I
K
I
D
E
F
T
I
T
P
E
T
T
---------
N
A
A
L
K
P
L
R
Q
H
V
G
M
V
F
Q
-
F
P
E
N
Q
L
F
-
E
-
E
T
V
R
Q
D
I
A
F
G
P
K
N
F
----
G
M
A
D
A
D
A
L
A
L
A
D
E
M
L
T
T
V
G
L
D
Q
S
Y
A
-
E
R
S
P
F
E
L
S
G
G
Q
M
R
R
V
A
I
A
G
V
L
A
M
Q
P
K
V
L
V
L
D
E
P
T
A
G
L
D
P
Q
G
R
Q
E
M
M
R
L
F
A
R
L
H
Q
E
Q
-
G
L
T
I
V
L
V
T
H
Q
M
E
D
V
A
Q
Y
A
E
Q
V
A
V
M
H
E
G
R
L
M
K
F
G
T
P
A
D
V
F
-----
S
N
R
E
W
L
Q
D
H
Q
L
D
V
P
Q
A
A
Q
F
A
R
R
L
R
D
R
G
L
T
F
P
K
Q
P
L
T
A
D
Q
L
A
D
Y
L
A
Q
Q
----------------------------------------------------------
21
PsiBlast_CBE
93.47
51%
-107
- C1 -
4MKI
4
ECFA2_CALS4
A:
[5-280]
M
P
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
--
D
K
---------
K
V
S
L
K
D
I
R
K
Q
V
G
L
V
F
Q
-
Y
P
E
Y
Q
L
F
-
E
-
E
T
V
F
K
D
I
A
F
G
P
S
N
L
----
G
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
-
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
-
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
-----
R
E
A
E
R
L
E
K
I
G
L
S
V
P
Q
I
T
S
L
A
R
E
L
R
K
R
G
V
P
I
P
P
D
V
L
T
I
E
E
A
K
E
H
I
L
R
Y
----------------------------------------------------------
3
PsiBlast_PDB
92.04
51%
-105
- C1 -
4MKI
4
ECFA2_CALS4
B:
[5-280]
M
P
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
--
D
K
---------
K
V
S
L
K
D
I
R
K
Q
V
G
L
V
F
Q
-
Y
P
E
Y
Q
L
F
-
E
-
E
T
V
F
K
D
I
A
F
G
P
S
N
L
----
G
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
-
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
-
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
-----
R
E
A
E
R
L
E
K
I
G
L
S
V
P
Q
I
T
S
L
A
R
E
L
R
K
R
G
V
P
I
P
P
D
V
L
T
I
E
E
A
K
E
H
I
L
R
Y
----------------------------------------------------------
2
PsiBlast_PDB
89.44
54%
-101
- C1 -
4HZU
-
ECFA2_LACBA
B:
[2-276]
-
A
I
A
F
E
H
V
T
Y
T
Y
Q
A
G
T
P
M
A
H
T
A
L
T
D
V
S
L
T
V
P
D
R
G
Y
L
A
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
A
L
L
K
P
T
S
G
T
I
K
I
D
E
F
T
I
T
P
E
T
T
---------
N
A
A
L
K
P
L
R
Q
H
V
G
M
V
F
Q
-
F
P
E
N
Q
L
F
-
E
-
E
T
V
R
Q
D
I
A
F
G
P
K
N
F
----
G
M
A
D
A
D
A
L
A
L
A
D
E
M
L
T
T
V
G
L
D
Q
S
Y
A
-
E
R
S
P
F
E
L
S
G
G
Q
M
R
R
V
A
I
A
G
V
L
A
M
Q
P
K
V
L
V
L
D
E
P
T
A
G
L
D
P
Q
G
R
Q
E
M
M
R
L
F
A
R
L
H
Q
E
Q
-
G
L
T
I
V
L
V
T
H
Q
M
E
D
V
A
Q
Y
A
E
Q
V
A
V
M
H
E
G
R
L
M
K
F
G
T
P
A
D
V
F
-----
S
N
R
E
W
L
Q
D
H
Q
L
D
V
P
Q
A
A
Q
F
A
R
R
L
R
D
R
G
L
T
F
P
K
Q
P
L
T
A
D
Q
L
A
D
Y
L
A
Q
Q
----------------------------------------------------------
4
PsiBlast_PDB
76.51
40%
-116
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[8-254]
--
L
K
V
E
E
L
N
Y
N
Y
S
D
G
T
----
H
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
K
P
I
D
Y
S
R
K
---------
G
--
I
M
K
L
R
E
S
I
G
I
V
F
Q
-
D
P
D
N
Q
L
F
-
S
-
A
S
V
Y
Q
D
V
S
F
G
A
V
N
M
----
K
L
P
E
D
E
I
R
K
R
V
D
N
A
L
K
R
T
G
I
-
E
H
L
K
-
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
-
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
-----
A
E
K
E
V
I
R
K
V
N
L
R
L
P
R
I
G
H
L
M
E
I
-----------------------------------------------------------------------------------
46
PsiBlast_CBE
75.52
33%
-109
- C1 -
3TUI
1
METN_ECOLI
D:
[25-273]
--
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
---------
S
-
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
-
H
-
F
N
L
L
S
-
S
-
R
T
V
F
G
N
V
A
L
P
L
E
L
D
----
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
--------
T
P
L
A
Q
K
F
I
Q
S
T
L
H
--
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
----------------------------------------------------------
43
PsiBlast_CBE
75.47
33%
-107
- C1 -
3TUZ
1
METN_ECOLI
C:
[25-273]
--
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
---------
S
-
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
-
H
-
F
N
L
L
S
-
S
-
R
T
V
F
G
N
V
A
L
P
L
E
L
D
----
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
--------
T
P
L
A
Q
K
F
I
Q
S
T
L
H
--
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
----------------------------------------------------------
47
PsiBlast_CBE
75.45
33%
-107
- C1 -
3TUI
1
METN_ECOLI
C:
[25-273]
--
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
---------
S
-
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
-
H
-
F
N
L
L
S
-
S
-
R
T
V
F
G
N
V
A
L
P
L
E
L
D
----
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
--------
T
P
L
A
Q
K
F
I
Q
S
T
L
H
--
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
----------------------------------------------------------
40
PsiBlast_CBE
75.44
33%
-110
* C1 *
3TUZ
1
METN_ECOLI
H:
[25-273]
--
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
---------
S
-
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
-
H
-
F
N
L
L
S
-
S
-
R
T
V
F
G
N
V
A
L
P
L
E
L
D
----
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
--------
T
P
L
A
Q
K
F
I
Q
S
T
L
H
--
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
----------------------------------------------------------
107
HHSearch
74.35
41%
-114
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[7-254]
-
I
L
K
V
E
E
L
N
Y
N
Y
S
D
G
----
T
H
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
K
P
I
D
Y
S
R
-----------
K
G
I
M
K
L
R
E
S
I
G
I
V
F
Q
-
D
P
D
N
Q
L
F
-
S
-
A
S
V
Y
Q
D
V
S
F
G
A
V
N
M
----
K
L
P
E
D
E
I
R
K
R
V
D
N
A
L
K
R
T
G
I
E
-
H
L
K
-
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
-
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
-----
A
E
K
E
V
I
R
K
V
N
L
R
L
P
R
I
G
H
L
M
E
I
-----------------------------------------------------------------------------------
44
PsiBlast_CBE
74.22
33%
-111
- C1 -
3TUI
1
METN_ECOLI
H:
[25-273]
--
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
---------
S
-
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
-
H
-
F
N
L
L
S
-
S
-
R
T
V
F
G
N
V
A
L
P
L
E
L
D
----
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
--------
T
P
L
A
Q
K
F
I
Q
S
T
L
H
--
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
----------------------------------------------------------
42
PsiBlast_CBE
73.89
33%
-107
- C1 -
3TUZ
1
METN_ECOLI
D:
[25-273]
--
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
---------
S
-
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
-
H
-
F
N
L
L
S
-
S
-
R
T
V
F
G
N
V
A
L
P
L
E
L
D
----
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
--------
T
P
L
A
Q
K
F
I
Q
S
T
L
H
--
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
----------------------------------------------------------
22
PsiBlast_CBE
73.85
38%
-105
- C1 -
4HLU
3
ECFA2_THEMA
B:
[5-232]
--
I
E
V
V
N
V
S
H
I
F
H
R
G
T
P
L
E
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
------
G
E
R
---------
K
K
G
Y
E
-
I
R
R
N
I
G
I
A
F
Q
-
Y
P
E
D
Q
F
F
-
A
-
E
R
V
F
D
E
V
A
F
A
V
K
N
F
----
Y
P
D
R
-
D
P
V
P
L
V
K
K
A
M
E
F
V
G
L
D
F
D
S
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
K
T
-
L
-
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
T
R
M
E
F
L
-----
E
K
Y
D
P
R
F
F
T
S
K
M
L
V
M
R
R
L
V
L
K
G
E
D
P
F
S
M
S
D
D
E
L
L
E
R
V
C
N
------------------------------------------------------------------
6
PsiBlast_PDB
73.60
38%
-104
- C1 -
4HLU
2
ECFA2_THEMA
A:
[5-232]
--
I
E
V
V
N
V
S
H
I
F
H
R
G
T
P
L
E
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
------
G
E
R
---------
K
K
G
Y
E
-
I
R
R
N
I
G
I
A
F
Q
-
Y
P
E
D
Q
F
F
-
A
-
E
R
V
F
D
E
V
A
F
A
V
K
N
F
----
Y
P
D
R
-
D
P
V
P
L
V
K
K
A
M
E
F
V
G
L
D
F
D
S
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
K
T
-
L
-
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
T
R
M
E
F
L
-----
E
K
Y
D
P
R
F
F
T
S
K
M
L
V
M
R
R
L
V
L
K
G
E
D
P
F
S
M
S
D
D
E
L
L
E
R
V
C
N
------------------------------------------------------------------
45
PsiBlast_CBE
72.74
33%
-100
- C1 -
3TUI
1
METN_ECOLI
G:
[25-273]
--
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
---------
S
-
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
-
H
-
F
N
L
L
S
-
S
-
R
T
V
F
G
N
V
A
L
P
L
E
L
D
----
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
--------
T
P
L
A
Q
K
F
I
Q
S
T
L
H
--
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
----------------------------------------------------------
105
HHSearch
72.65
35%
-110
- C1 -
3TUI
1
METN_ECOLI
C:
[24-255]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
-
H
F
N
--
L
L
-
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
----
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
----------------------------------------------------------
41
PsiBlast_CBE
72.31
33%
-106
- C1 -
3TUZ
1
METN_ECOLI
G:
[25-273]
--
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
---------
S
-
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
-
H
-
F
N
L
L
S
-
S
-
R
T
V
F
G
N
V
A
L
P
L
E
L
D
----
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
--------
T
P
L
A
Q
K
F
I
Q
S
T
L
H
--
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
----------------------------------------------------------
119
Fugue
68.12
29%
-100
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
-
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
-
L
S
---------
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
-
H
F
-
N
L
L
S
-
S
-
R
T
V
F
G
N
V
A
L
P
L
E
L
D
----
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
SHPKT
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
LLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV
116
HHSearch
67.78
35%
-114
- C1 -
1B0U
4
HISP_SALTY
A:
[6-245]
-
K
L
H
V
I
D
L
H
K
R
Y
G
G
-----
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDGQLKVAD
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
-
H
F
N
--
L
W
S
H
-
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L---
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
-
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
-----
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
S
L
K
K
L
E
H
------------------------------------------------------------------------------------
50
PsiBlast_CBE
67.66
36%
-113
- C1 -
1L2T
4
Y796_METJA
A:
[2-223]
--
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
-
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
---------
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
----
T
A
L
E
N
V
E
L
-
P
L
I
F
KYR
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
D
G
K
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
R
-----------------------------------------------------------------------------------------------------------------