@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu02030: (2016-06-03 )
MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTDILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVMQFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDGRLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEELTLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT
Atome Classification :
(20 SA)
----------------------------------------------------.........10........20........30........40.......-.50........60..-----......70........80........90...-----.....100......-.110.......120.......130.......140.......150.....----.-.----160--........170..----------------..-----------.--------.--------.--180.----------------..-.....190.......200---------....---------.---..-.---.---------210-----.---------.---...-------.--.--.--.220.......230..-------...--..240.....---..250....--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------
M
A
L
K
L
L
K
K
L
L
FDRPLKN
G
V
I
LNHQ
Y
K
I
E
E
C
LGMGG
Y
G
L
V
Y
L
C
T
D
I
LAQ-
T
P
Y
V
L
K
QLRPTKA
K
K
-----
E
K
E
K
V
R
F
Q
Q
E
I
K
L
L
K
NIHHPQI
P
G
F
I
D
E
F
I
I-----DGQ
A
Y
Y
V
M
Q
FIEGE-
N
I
E
E
L
L
F
F
R
KQ
P
F
T
E
L
M
A
L
Q
L
I
S
Q
L
L
E
I
I
E
Y
L
H
DR
L
I
F
HSDIRT
P
N
I
I
I----N-D----G
R
---
L
C
L
I
DFGLAKQL
T
----------------
P
E
-----------
E
--------
M
--------
E
--
E
I
-
K
----------------VR-KQD
D
F
F
D
L
G
E
T
L
L
F
L
L
-----------
Y
S
Q
Y---------K---GK-K---K---------K-------N---------G---
T
W
L
-------
E
--
E
--
L
--T
L
T
K
E
V
T
L
L
L
K
R
L
LG
I
-------
E
E
E
--
Y
Q
H
T
A
S
I
R
E
D
---
L
N
R
A
I
Q
SVT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
75.74
23%
-101
- C1 -
3H4J
-
SNF1_SCHPO
B:
[27-356]
---------------------------------------------------------------
S
K
R
H
I
G
------
P
Y
I
I
R
E
T
L
G
E
G
S
F
G
K
V
K
L
A
T
H
Y
K
T
Q
-
Q
K
V
A
L
K
F
I
S
R
Q
L
L
K
K
-----
S
D
M
H
M
R
V
E
R
E
I
S
Y
L
K
L
L
R
H
P
H
I
I
K
L
Y
D
V
I
T
T
-----
P
T
D
I
V
M
V
I
E
Y
A
G
G
E
-
L
F
D
Y
I
V
E
K
K
R
--
M
T
E
D
E
G
R
R
F
F
Q
Q
I
I
C
A
I
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
----
D
D
N
----
L
N
---
V
K
I
A
D
F
G
L
S
N
I
M
T
DGNFLKTSCGSPNYAA
P
E
-----------
V
--------
I
--------
N
--
G
K
-
L
----------------
Y
A
G
P
E
V
D
V
W
S
C
G
I
V
L
Y
V
M
L
-----------
V
G
R
L
PFDDEFIPN
L
---
F
K
-
K
---
V
---------
N
-------
S
---------
C
---
V
Y
V
-------
M
--
P
--
D
--
F
L
S
P
G
A
Q
S
L
I
R
R
M
I
V
A
DPMQRIT
I
Q
E
--
I
R
R
D
P
W
F
N
V
N
---
L
P
D
Y
L
R
P
M
E
EVQGSYADSRIVSKLGEAMGFSEDYIVEALRSDENNEVKEAYNLLHENQVIQEKLEHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
72.07
24%
-113
- C1 -
3H4J
-
SNF1_SCHPO
B:
[30-282]
------------------------------------------------------------------------
H
I
G
P
Y
I
I
R
E
T
L
G
E
G
S
F
G
K
V
K
L
A
T
H
Y
K
T
Q
-
Q
K
V
A
L
K
F
I
S
R
Q
L
L
K
K
-----
S
D
M
H
M
R
V
E
R
E
I
S
Y
L
K
L
L
R
H
P
H
I
I
K
L
Y
D
V
I
T
T
-----
P
T
D
I
V
M
V
I
E
Y
A
-
G
G
-
E
L
F
D
Y
I
V
-
E
K
K
R
M
T
E
D
E
G
R
R
F
F
Q
Q
I
I
C
A
I
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
----
D
-
D
N---
L
N
---
V
K
I
A
D
F
G
L
S
N
I
M
T
----------------
D
G
N
F
L
K
T
S
C
G
---
S
PNYAAPE-
V
--------
I
N-
G
K
L
Y
----------------
A
G
-
P
E
V
D
V
W
S
C
G
I
V
L
Y
V
M
L
-----------
V
G
R
L
---------
P
FD-
D
E
-
F
---
I
---------
P
NLFK---
K
---------
V
N
S
C
V
Y
V
-------
M
--
P
--
D
--
F
L
S
P
G
A
Q
S
L
I
R
R
M
I
V
A
-------
D
P
M
Q-
R
I
T
I
Q
E
I
R
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
70.50
22%
-104
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[8-268]
-----------------------------------------------------------------------
R
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
-
Q
E
Y
A
A
M
I
I
N
T
K
K
L
-
S
-----
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
-----
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
-
E
L
F
E
D
I
V
-
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
----
A
-
S
KLKG
A
A
---
V
K
L
A
D
F
G
L
A
I
E
V
E
----------------
G
E
Q
Q
A
W
FGFAG--
T
PGYLS
P
E
V
L
--------
R
--
K
D
-
P
----------------
Y
G
-
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
-----------
V
G
Y
P
---------
P
FW-
D
E
-
D
---
Q
H
R
L
Y
Q
Q
I
K
A
G
-------
A
---------
Y
---
D
F
P
-------
S
PE
W
--
D
--
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
-------
N
P
S
K-
R
I
T
A
A
E
A
L
K
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
70.08
20%
-121
- C1 -
4BKY
2
MELK_HUMAN
A:
[8-261]
------------------------------------------------------------------------
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
-
E
M
V
A
I
K
I
M
D
K
N
T
L
---------
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
-----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
-
E
L
F
D
Y
I
I
-
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
----
D
-
E
Y---
H
K
---
L
K
L
I
D
F
G
L
C
A
--------------------------------
S
LAYAA
P
E
-
L
--------
I
Q
-
G
K
-------------------
G
-
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
-----------
C
G
F
L
---------
P
FD-
D
D
-
N
---
V
---------
M
A
L
Y
K
---
K
---------
I
M
R
G
K
Y
D
-------
V
--
P
--
K
--
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
-------
D
P
K
K-
R
I
S
M
K
N
L
L
N
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
68.80
22%
-134
- C1 -
3UC3
3
SRK2I_ARATH
A:
[18-293]
------------------------------------------------------------------------
D
S
D
R
Y
D
F
V
K
D
I
G
S
G
N
F
G
V
A
R
L
M
R
D
K
L
T
K
-
E
L
V
A
V
K
Y
I
E
R
G
A
A
---------
I
D
E
N
V
Q
R
E
I
I
N
H
R
S
L
R
H
P
N
I
V
R
F
K
E
V
I
L
T
-----
P
T
H
L
A
I
I
M
E
Y
A
S
G
G
-
E
L
Y
E
R
I
C
-
N
A
G
R
F
S
E
D
E
A
R
F
F
F
Q
Q
L
L
S
G
V
S
Y
C
H
S
M
Q
I
C
H
R
D
L
K
L
E
N
T
L
L
----
D
-
G
SPA-
P
R
---
L
K
I
C
D
F
G
Y
S
----------------------------------PAYIA
P
E
V
L
--------
L
--
R
Q
-
E
Y---------------
D
G
-
K
I
A
D
V
W
S
C
G
V
T
L
Y
V
M
L
-----------
V
G
A
Y
---------
P
FE---------P--------
R
D
Y
R
K
T
I
Q
R
I
L
S
VK----
Y
---
S
I
P
-------
D
--
D
--
I
--
R
I
S
P
E
C
C
H
L
I
S
R
I
F
V
A
-------
D
P
A
T-
R
I
S
I
P
E
I
K
T
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
65.61
26%
-105
- C1 -
1TKI
-
TITIN_HUMAN
A:
[20-275]
------------------------------------------------------------------------
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
-
K
T
Y
M
A
K
F
V
K
V
K
G
---------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
H
R
N
I
L
H
L
H
E
S
F
E
S
-----
M
E
E
L
V
M
I
F
E
F
I
S
G
L
-
D
I
F
E
R
I
N
T
S
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
----
Q
-
T
RRS-
S
T
---
I
K
I
I
E
F
G
Q
A
R
Q
L
K
----------------
P
G
D
N
F
R
L
L
F
T---
A
PEYYA
P
E
V
H
--------
Q
--
H
D
-
V
----------------
V
S
-
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
-----------
S
G
I
N
---------
P
FL-
A
E
-
T
---
N
Q
Q
I
I
E
N
I
M
N
A
-------
E
---------
Y
---
T
F
D
-------
E
--
E
AF
K
--
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
-------
E
R
K
S-
R
M
T
A
S
E
A
L
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
64.09
23%
-112
- C1 -
1KOB
1
?
A:
[47-305]
----------------------------------------------------------------------
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
-
R
V
F
V
A
K
F
I
N
T
P
Y
P
--------
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
H
H
P
K
L
I
N
L
H
D
A
F
E
D
-----
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
-
E
L
F
D
R
I
A
A
E
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
----
E
-
T
KKA-
S
S
---
V
K
I
I
D
F
G
L
A
T
K
L
N
----------------
P
D
E
I
V
K
V
T
TA---
T
AEFAA
P
E
I
V
--------
D
--
R
E
-
P
----------------
V
G
-
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
-----------
S
G
L
S
---------
P
FA-
G
E
-
D
D
L
E
T
L
Q
N
V
K
R
---
C
-------
D
---------
W
---
E
F
D
-------
E
--
D
AF
S
--
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
-------
E
P
R
K-
R
L
T
V
H
D
A
L
E
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
63.49
20%
-110
- C1 -
3TKI
2
CHK1_HUMAN
A:
[5-262]
------------------------------------------------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
-
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
-----
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
-
E
L
F
D
R
I
E
P
-
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
----
D
-
E
R---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
----------------
Y
N
N
R
E
R
L
L
N
K
MCG
T
LPYVA
P
E
-
L
--------
L
K
R
R
E
-
F
----------------
H
A
-
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
-----------
A
G
E
L
---------
P
WD-
Q
P
S
D
SC-
Q
---------
E
-------
Y
---------
S
---
D
W
K
E
KKTYLN
P
--
W
--
K
--
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
-------
N
P
S
A-
R
I
T
I
P
D
I
K
K
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
63.26
23%
-99
- C1 -
3DLS
6
PASK_HUMAN
A:
[17-275]
-------------------------------------------------------------------
A
C
E
G
E
Y
S
Q
K
Y
S
T
M
S
P
L
G
S
G
A
F
G
F
V
W
T
A
V
D
K
E
K
N
-
K
E
V
V
V
K
F
I
K
K
E
K
V
L
E
DCWIE
D
P
K
L
G
K
V
T
L
E
I
A
I
L
S
R
V
E
H
A
N
I
I
K
V
L
D
I
F
E
N
-----
Q
G
F
F
Q
L
V
M
E
K
H
G
S
G
L
D
L
F
A
F
I
D
-
R
H
P
R
L
D
E
P
L
A
S
Y
I
F
R
Q
L
V
S
A
V
G
Y
L
R
L
K
D
I
I
H
R
D
I
K
D
E
N
I
V
I
----
A
-
E
D---
F
T
---
I
K
L
I
D
F
G
S
A
A
Y
L
E
----------------
R
G
KLFYTFCG---
T
IEYCA
P
E
V
L
--------
M
--
G
N
P
Y
----------------
R
G
-
P
E
L
E
M
W
S
L
G
V
T
L
Y
T
L
V
-----------
F
E
E
N
---------
P
FC-
E
L
-
E
E--
T
---------
V
-------
E
---------
A
---
A
I
H
-------
P
--
P
--
Y
--
L
V
S
K
E
L
M
S
L
V
S
G
L
L
Q
P
-------
V
P
E
R-
R
T
T
L
E
K
L
V
T
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
62.99
28%
-102
- C1 -
1TKI
-
TITIN_HUMAN
A:
[18-338]
----------------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
-
K
T
Y
M
A
K
F
V
K
----
V
K
-----
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
H
R
N
I
L
H
L
H
E
S
F
E
S
-----
M
E
E
L
V
M
I
F
E
F
I
S
G
L
-
D
I
F
E
R
I
N
T
S
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
----
Q
-
T
----
R
R
SST
I
K
I
I
E
F
G
Q
A
R
Q
L
K
----------------
P
G
-----------
D
--------
N
--------
F
--
R
L
-
L
F
TAPEYYA
P
E
V
H
Q
HDV
V
S
-
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
SGINPFLAET
N
Q
Q
I
I
---------
E
---
N
I
-
M
---
N
---------
A
-------
E
---------
Y
---
T
F
D
-------
E
--
E
--
A
FK
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
-------
E
R
K
--
S
R
M
T
A
S
E
A
L
Q
HPW
L
K
Q
K
I
E
R
V
S
TKVIRT
L
K
H
R
R
Y
Y
H
T
L
IKKDLNMVVSAARISCGGAIRSQKG
V
S
V
A
K
V
K
V
A
SI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
62.86
21%
-111
- C1 -
4LGD
3
STK3_HUMAN
A:
[24-285]
------------------------------------------------------------------------
P
E
E
V
F
D
V
L
E
K
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
K
E
S
G
-
Q
V
V
A
I
K
Q
V
P
V
E
S
----------
D
L
Q
E
I
I
K
E
I
S
I
M
Q
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
-----
N
T
D
L
W
I
V
M
E
Y
C
G
A
G
-
S
V
S
D
I
I
R
L
R
N
K
T
L
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
N
I
K
A
G
N
I
L
L
----
N
-
T
E---
G
H
---
A
K
L
A
D
F
G
V
A
G
Q
L
T
----------------
D
T
MAKRN
T
V
I
G
--
T
PFWMA
P
E
V
I
--------
Q
--
E
I
-
G
----------------
Y
N
-
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
-----------
E
G
K
P
---------
P
YA-
D
I
-
H
---
P
M
--------
R
-------
A
I
F
M
I
P
T
NPP
P
---
T
F
R
-------
K
--
P
--
E
--
L
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
-------
N
P
E
Q-
R
A
T
A
T
Q
L
L
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
62.11
21%
-112
- C1 -
2BDW
-
KCC2D_CAEEL
A:
[5-268]
---------------------------------------------------------------------
S
T
K
F
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
-
L
E
F
A
A
K
I
I
N
T
K
K
L
-
S
-----
A
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
-----
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
-
E
L
F
E
D
I
V
-
A
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
----
A
-
S
KAKG
A
A
---
V
K
L
A
D
F
G
L
A
I
E
V
N
----------------
D
S
E
A
W
HGFAG---
T
PGYLS
P
E
V
L
--------
K
--
K
D
-
P
----------------
Y
S
-
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
-----------
V
G
Y
P
---------
P
FW-
D
E
-
D
---
Q
H
R
L
Y
A
Q
I
K
A
G
-------
A
---------
Y
---
D
Y
P
-------
S
PE
W
--
D
--
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
-------
N
P
K
K-
R
I
T
A
D
Q
A
L
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
61.21
22%
-103
- C1 -
2PZI
7
PKNG_MYCTU
A:
[1-677]
GSHMLGGGL
V
E
I
P
R
A
PDIDPLEALMT
N
P
V
V
P
ESKRFCWNCGRPVGRSGAS
E
G
W
C
P
Y
C
G
S
P
Y
S
F
L
P
Q
L
N
P
G
D
I
V
A
G
Q
Y
E
V
K
G
C
I
A
H
G
G
L
G
W
I
Y
L
A
L
D
R
N
V
N
G
R
P
V
V
L
K
G
L
V
H
S
G
--
D
-----
A
E
A
Q
A
M
A
M
A
E
R
Q
F
L
A
E
V
V
H
P
S
I
V
Q
I
F
N
F
V
E
H
T
D
RHG
D
P
V
G
Y
I
V
M
E
Y
V
G
G
Q
-
S
L
-------
K
Q
K
L
P
V
A
E
A
I
A
Y
L
L
E
I
L
P
A
L
S
Y
L
H
S
I
G
L
V
Y
N
D
L
K
P
E
N
I
M
L
----
T
-
E
----
E
Q
---
L
K
L
I
D
L
G
A
V
S
R
I
N
SF
G
Y
L
Y
G
T
P
GFQ----
A
P
-----------
E
--------
I
--------
V
--
R
T
-
G
----------------
P
T
-
V
A
T
D
I
Y
T
V
G
R
T
L
A
A
L
T
-----------
L
D
L
P
---------
T
R
NG
R
Y
-
V
---
D
---------
G
-------
L
---------
P
---
E
D
D
-------
P
--
V
--
L
--
K
T
Y
D
S
Y
G
R
L
L
R
R
A
I
D
P
-------
D
P
R
QR
F
T
T
A
E
E
M
S
A
Q
---
L
T
G
V
L
R
E
V
V
A
Q
D
T
G
V
P
R
P
G
L
S
TIFSPSRSTFGVD
L
L
V
A
H
T
DVYLDGQVHAEKLT
A
N
E
I
V
T
A
L
S
V
P
L
VDPTDVA
A
S
V
L
Q
A
T
V
LSQ
P
V
Q
T
L
D
S
L
R
A
A
R
H
GDFSES
V
E
L
P
L
M
E
V
R
A
L
L
D
L
GD
V
A
K
A
T
R
K
L
D
D
L
A
E
R
VGWR
W
R
L
V
W
Y
R
A
V
A
E
L
L
T
GD
Y
D
S
A
T
K
H
F
T
E
V
L
D
T
F
PGE
L
A
P
K
L
A
L
A
A
T
A
E
L
A
GNTDEHK
F
Y
Q
T
V
W
S
T
NDGV
I
S
A
A
F
G
L
A
R
A
R
S
A
E
GD
R
V
G
A
V
R
T
L
D
E
VPPTSRH
F
T
T
A
R
L
T
S
A
V
T
L
LVT
E
E
Q
I
R
D
A
A
R
R
V
E
A
LPPTEPR
V
L
Q
I
R
A
L
V
L
G
G
A
L
D
W
L
K
D
N
KASTNHILGFPFT
S
H
G
L
R
L
G
V
E
A
S
L
R
S
L
A
R
V
APT
Q
R
H
R
Y
T
L
V
D
M
A
N
K
V
RP
42
HHSearch
61.17
21%
-128
- C1 -
3I6U
-
CHK2_HUMAN
A:
[216-483]
------------------------------------------------------------------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
-
K
K
V
A
I
R
I
I
S
K
R
K
F
A
I
G--------
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
------
E
D
Y
Y
I
V
L
E
L
M
E
G
G
-
E
L
F
D
K
V
V
-
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
----
S
-
S
QEE
D
C
L
---
I
K
I
T
D
F
G
H
S
K
I
L
G
------------------------------PTYLAPE-
V
--------
L
V--
A
-
G
----------------
Y
N
-
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
-----------
S
G
Y
P
---------
P
F
S
-
E
H
-
R
T--
Q
VS
L
K
D
Q
I
T
S
G
-------
K
---------
Y
---
N
F
I
-------
P
--
E
VW
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
-------
D
P
K
A-
R
F
T
T
E
E
A
L
R
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
60.46
30%
-145
- C1 -
3V51
1
?
A:
[22-182]
----------------------------------------------------------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
-
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
-----
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
-----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
-
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESKS
K
-
D
----
A
N
---
I
R
I
I
D
F
G
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
60.19
21%
-112
- C1 -
3FE3
-
MARK3_HUMAN
A:
[51-304]
-----------------------------------------------------------------------
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
-
R
E
V
A
I
K
I
I
D
K
T
Q
L
N
------
P
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
-----
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
-
E
V
F
D
Y
L
V
-
A
H
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
----
D
-
A
D---
M
N
---
I
K
I
A
D
F
G
F
S
N
E
F
T
----------------
V
G
GKLDAFCG---
A
--------
P
PYAAPELF
Q
--
G
K
-
K
Y---------------
D
G
-
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
-----------
S
G
S
L
---------
P
FD-
G
Q
-
N
---
L
---------
K
E
L
R
E
R
V
L
R
---------
G
---
K
Y
R
-------
I
--
P
--
F
--
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
-------
N
P
I
K-
R
G
T
L
E
Q
I
M
K
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
59.77
21%
-108
- C1 -
4RED
-
AAPK1_HUMAN
A:
[14-267]
------------------------------------------------------------------------
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
-
H
A
V
A
V
K
I
L
N
R
Q
K
I
R
S
-----
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
-----
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
-
E
L
F
D
Y
I
C
-
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
----
D
-
A
H---
M
N
---
A
K
I
A
D
F
G
L
S
N
M
M
S
----------------
D
------------
S
P
N
Y
A
A
P
E
-
V
--------
I
S
-
G
R
L
Y
----------------
A
G
-
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
-----------
C
G
T
L
---------
P
FD-
D
D
-
H
---
V
---------
P
TLF----
K
K------------
I
F
Y
-------
T
--
P
--
Q
--
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
-------
D
P
M
K-
R
A
S
I
K
D
I
R
E
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
59.41
30%
-139
- C1 -
4ONA
1
?
A:
[22-176]
----------------------------------------------------------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
-
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
-----
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
-----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
-
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESKS
K
-
D
----
A
N
---
I
R
I
I
D
F
G
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
59.28
30%
-141
- C1 -
3I7B
2
?
A:
[23-179]
-----------------------------------------------------------------------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
-
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
-----
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
-----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
-
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESKS
K
-
D
----
A
N
---
I
R
I
I
D
F
G
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
59.02
18%
-113
- C1 -
4FIE
1
PAK4_HUMAN
A:
[152-401]
---------------------------------------------------------------------------
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
-
K
L
V
A
V
K
K
M
D
L
R
K
--------
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
-----
G
D
E
L
W
V
V
M
E
F
L
E
G
G
-
A
L
T
D
I
V
T
--
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
----
T
-
H
D---
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
----------------
K
E
VPRRKSLVG--
T
PYWM
A
P
E
L
I
--------
S
--
R
L
-
P
----------------
Y
G
-
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
-----------
D
G
E
P
---------
P
YF-
N
E
-
P
P
L
K
A
---------
M
K
M
I
R
D--
N
---------
L
PP-
R
L
K
-------
N
--
L
--
H
--
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
-------
D
P
A
Q-
R
A
T
A
A
E
L
L
K
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------