@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03890: (2016-06-06 )
MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRELAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEIHIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITRLISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQVKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYIIEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYKQRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTVKGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFARLKEEDIQEGVQRLFKAVYGHKKIPVTGD
Atome Classification :
(20 SA)
.........-10........20........30........40........50........60........70........80........90........100.......110.......120.........130.......140.......150.......160......-----.-170..-......180.......190-.--.....-..200.......210.......220....---..---.230-----...----.----.--------.-----------..240-.........250.......260.......270-.......280.......290.......---300-.........310...-....320.....-.-----.330.-..--....340..-.....350.......-360........370.......380.....---.-.-390.--......400......-.-----410.......-420.......430....----------...440.......450.......460......--.470.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
D
I
T
I
T
LDR-SEQ
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
SRNLLPHSKVP
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
AEG
Y
L
Y
A
I
ERKGF
F
V
E
E
L
D
M
FSAEEHPPFALP
D
D
L
K
E
IHIDQSD
W
I
S
F
SHMSSDTD--HF
P
I
K
S
W
F
R
C
E
Q
K
A
ASRSYRTLGDMSHP
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
TRGV-----K-CR-PE-
Q
M
I
IG
A
G
T
Q
V
L
M
Q
L
L
T
E
-L-L--
P
K
E
A
V
-YAMEEP
G
Y
R
R
M
Y
Q
L
L
K
NAGK
Q
V
K
T
I
M
LDE---KG---
M
S
I
------
A
E
I
----T----R--------Q-----------QP
D
---
V
L
V
TTPSHQFPSGTIM
P
V
S
R
R
I
Q
L
L
NWAAEEP-
R
R
Y
I
IEDDYDSE
F
T
YDVDS
I
P
A
L
Q
S
L
D
---
R
---
F
Q
N
V
I
Y
MGT
F
S
K
S
LL-PG
L
R
I
S
Y
M
VL
P
P
-
E
-----
L
L
R
A
Y
-
K
Q--RGY
D
L
Q
T
C
S
-
S
L
T
Q
L
T
L
Q
E
F
I
ES
G
E
-
Y
Q
-
K
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
EAEFS---G-
E
-
V
T
V
K
--GANA
G
L
H
F
V
TEFDTR-R-----
T
E
Q
D
I
L
S
H
AA-G
L
Q
L
E
I
F
G
M
S
RFNLKEN----------KRQTGR
P
A
L
I
I
G
F
A
RL
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
V
--YGHKKIPVTGD
22
PsiBlast_CBE
81.73
100%
-105
- C3 -
4MGR
5
GABR_BACSU
C:
[1-475]
M
D
I
T
I
T
L
D
R
-
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
E
L
D
M
F
S
A
E
E
H
P
P
F
A
L
P
D
D
L
K
E
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
--
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
Y
R
T
L
G
D
M
S
H
P
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
-----
K
-
C
R
-
P
E
-
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
E
-
L
-
L
--
P
K
E
A
V
-
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
---
K
G
---
M
S
I
------
A
E
I
----
T
----
R
--------
Q
-----------
Q
P
D
---
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
-
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
---
F
Q
N
V
I
Y
M
G
T
F
S
K
S
L
L
-
P
G
L
R
I
S
Y
M
V
L
P
P
-
E
-----
L
L
R
A
Y
-
K
Q
--
R
G
Y
D
L
Q
T
C
S
-
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
-
Y
Q
-
K
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
---
G
-
E
-
V
T
V
K
--
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
-
R
-----
T
E
Q
D
I
L
S
H
A
A
-
G
L
Q
L
E
I
F
G
M
S
R
F
N
L
K
E
N
----------
K
R
Q
T
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
V
--
Y
G
H
K
K
I
P
----
21
PsiBlast_CBE
80.83
100%
-110
- C3 -
4MGR
4
GABR_BACSU
D:
[1-472]
M
D
I
T
I
T
L
D
R
-
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
E
L
D
M
F
S
A
E
E
H
P
P
F
A
L
P
D
D
L
K
E
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
--
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
Y
R
T
L
G
D
M
S
H
P
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
-----
K
-
C
R
-
P
E
-
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
E
-
L
-
L
--
P
K
E
A
V
-
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
---
K
G
---
M
S
I
------
A
E
I
----
T
----
R
--------
Q
-----------
Q
P
D
---
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
-
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
---
F
Q
N
V
I
Y
M
G
T
F
S
K
S
L
L
-
P
G
L
R
I
S
Y
M
V
L
P
P
-
E
-----
L
L
R
A
Y
-
K
Q
--
R
G
Y
D
L
Q
T
C
S
-
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
-
Y
Q
-
K
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
---
G
-
E
-
V
T
V
K
--
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
-
R
-----
T
E
Q
D
I
L
S
H
A
A
-
G
L
Q
L
E
I
F
G
M
S
R
F
N
L
K
E
N
----------
K
R
Q
T
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
V
--
Y
G
H
K
-------
68
Fugue
80.40
100%
-109
- C3 -
4MGR
3
GABR_BACSU
A:
[2-469]
-
D
I
T
I
T
L
D
R
-
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
E
L
D
M
F
S
A
E
E
H
P
P
F
A
L
P
D
D
L
K
E
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
--
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
Y
R
T
L
G
D
M
S
H
P
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
-----
K
-
C
R
-
P
E
-
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
E
-
L
-
L
--
P
K
E
A
V
-
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
---
K
G
---
M
S
I
------
A
E
I
----
T
----
R
--------
Q
-----------
Q
P
D
---
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
-
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
---
F
Q
N
V
I
Y
M
G
T
F
S
K
S
L
L
-
P
G
L
R
I
S
Y
M
V
L
P
P
-
E
-----
L
L
R
A
Y
-
K
Q
--
R
G
Y
D
L
Q
T
C
S
-
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
-
Y
Q
-
K
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
---
G
-
E
-
V
T
V
K
--
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
-
R
-----
T
E
Q
D
I
L
S
H
A
A
-
G
L
Q
L
E
I
F
G
M
S
R
F
N
L
K
E
N
----------
K
R
Q
T
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
V
--
Y
----------
1
PsiBlast_PDB
80.40
100%
-109
- C3 -
4MGR
3
GABR_BACSU
A:
[2-469]
-
D
I
T
I
T
L
D
R
-
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
E
L
D
M
F
S
A
E
E
H
P
P
F
A
L
P
D
D
L
K
E
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
--
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
Y
R
T
L
G
D
M
S
H
P
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
-----
K
-
C
R
-
P
E
-
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
E
-
L
-
L
--
P
K
E
A
V
-
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
---
K
G
---
M
S
I
------
A
E
I
----
T
----
R
--------
Q
-----------
Q
P
D
---
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
-
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
---
F
Q
N
V
I
Y
M
G
T
F
S
K
S
L
L
-
P
G
L
R
I
S
Y
M
V
L
P
P
-
E
-----
L
L
R
A
Y
-
K
Q
--
R
G
Y
D
L
Q
T
C
S
-
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
-
Y
Q
-
K
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
---
G
-
E
-
V
T
V
K
--
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
-
R
-----
T
E
Q
D
I
L
S
H
A
A
-
G
L
Q
L
E
I
F
G
M
S
R
F
N
L
K
E
N
----------
K
R
Q
T
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
V
--
Y
----------
24
PsiBlast_CBE
80.00
99%
-106
- C3 -
4N0B
2
GABR_BACSU
D:
[2-471]
-
D
I
T
I
T
L
D
R
-
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
E
L
D
M
F
S
A
E
E
H
P
P
F
A
L
P
D
D
L
K
E
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
--
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
Y
R
T
L
G
D
M
S
H
P
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
-----
K
-
C
R
-
P
E
-
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
E
-
L
-
L
--
P
K
E
A
V
-
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
---
K
G
---
M
S
I
------
A
E
I
----
T
----
R
--------
Q
-----------
Q
P
D
---
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
-
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
---
F
Q
N
V
I
Y
M
G
T
F
S
K
S
L
L
-
P
G
L
R
I
S
Y
M
V
L
P
P
-
E
-----
L
L
R
A
Y
-
K
Q
--
R
G
Y
D
L
Q
T
C
S
-
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
-
Y
Q
-
K
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
---
G
-
E
-
V
T
V
K
--
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
-
R
-----
T
E
Q
D
I
L
S
H
A
A
-
G
L
Q
L
E
I
F
G
M
S
R
F
N
L
K
E
N
--------------
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
V
--
Y
G
H
--------
26
PsiBlast_CBE
79.86
99%
-108
- C3 -
4N0B
2
GABR_BACSU
B:
[3-471]
--
I
T
I
T
L
D
R
-
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
E
L
D
M
F
S
A
E
E
H
P
P
F
A
L
P
D
D
L
K
E
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
--
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
Y
R
T
L
G
D
M
S
H
P
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
-----
K
-
C
R
-
P
E
-
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
E
-
L
-
L
--
P
K
E
A
V
-
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
---
K
G
---
M
S
I
------
A
E
I
----
T
----
R
--------
Q
-----------
Q
P
D
---
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
-
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
---
F
Q
N
V
I
Y
M
G
T
F
S
K
S
L
L
-
P
G
L
R
I
S
Y
M
V
L
P
P
-
E
-----
L
L
R
A
Y
-
K
Q
--
R
G
Y
D
L
Q
T
C
S
-
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
-
Y
Q
-
K
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
---
G
-
E
-
V
T
V
K
--
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
-
R
-----
T
E
Q
D
I
L
S
H
A
A
-
G
L
Q
L
E
I
F
G
M
S
R
F
N
L
K
E
N
--------------
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
V
--
Y
G
H
--------
2
PsiBlast_PDB
79.51
99%
-104
- C3 -
4N0B
2
GABR_BACSU
A:
[3-475]
--
I
T
I
T
L
D
R
-
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
E
L
D
M
F
S
A
E
E
H
P
P
F
A
L
P
D
D
L
K
E
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
--
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
Y
R
T
L
G
D
M
S
H
P
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
-----
K
-
C
R
-
P
E
-
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
E
-
L
-
L
--
P
K
E
A
V
-
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
---
K
G
---
M
S
I
------
A
E
I
----
T
----
R
--------
Q
-----------
Q
P
D
---
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
-
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
---
F
Q
N
V
I
Y
M
G
T
F
S
K
S
L
L
-
P
G
L
R
I
S
Y
M
V
L
P
P
-
E
-----
L
L
R
A
Y
-
K
Q
--
R
G
Y
D
L
Q
T
C
S
-
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
-
Y
Q
-
K
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
---
G
-
E
-
V
T
V
K
--
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
-
R
-----
T
E
Q
D
I
L
S
H
A
A
-
G
L
Q
L
E
I
F
G
M
S
R
F
N
L
K
E
--------------
T
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
V
--
Y
G
H
K
K
I
P
----
25
PsiBlast_CBE
78.63
99%
-101
- C3 -
4N0B
1
GABR_BACSU
C:
[3-469]
--
I
T
I
T
L
D
R
-
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
E
L
D
M
F
S
A
E
E
H
P
P
F
A
L
P
D
D
L
K
E
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
--
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
Y
R
T
L
G
D
M
S
H
P
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
-----
K
-
C
R
-
P
E
-
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
E
-
L
-
L
--
P
K
E
A
V
-
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
---
K
G
---
M
S
I
------
A
E
I
----
T
----
R
--------
Q
-----------
Q
P
D
---
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
-
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
---
F
Q
N
V
I
Y
M
G
T
F
S
K
S
L
L
-
P
G
L
R
I
S
Y
M
V
L
P
P
-
E
-----
L
L
R
A
Y
-
K
Q
--
R
G
Y
D
L
Q
T
C
S
-
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
-
Y
Q
-
K
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
---
G
-
E
-
V
T
V
K
--
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
-
R
-----
T
E
Q
D
I
L
S
H
A
A
-
G
L
Q
L
E
I
F
G
M
S
R
F
N
L
K
E
--------------
T
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
V
--
Y
----------
23
PsiBlast_CBE
77.32
100%
-105
- C3 -
4MGR
6
GABR_BACSU
B:
[2-472]
-
D
I
T
I
T
L
D
R
-
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
E
L
D
M
F
S
A
--------
P
D
D
L
K
E
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
--
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
Y
R
T
L
G
D
M
S
H
P
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
-----
K
-
C
R
-
P
E
-
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
E
-
L
-
L
--
P
K
E
A
V
-
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
---
K
G
---
M
S
I
------
A
E
I
----
T
----
R
--------
Q
-----------
Q
P
D
---
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
-
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
---
F
Q
N
V
I
Y
M
G
T
F
S
K
S
L
L
-
P
G
L
R
I
S
Y
M
V
L
P
P
-
E
-----
L
L
R
A
Y
-
K
Q
--
R
G
Y
D
L
Q
T
C
S
-
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
-
Y
Q
-
K
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
---
G
-
E
-
V
T
V
K
--
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
-
R
-----
T
E
Q
D
I
L
S
H
A
A
-
G
L
Q
L
E
I
F
G
M
S
R
F
N
L
K
E
N
----------
K
R
Q
T
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
V
--
Y
G
H
K
-------
47
HHSearch
73.14
96%
-113
- C3 -
4TV7
-
GABR_BACSU
A:
[4-463]
---
T
I
T
L
D
R
S
E
Q
A
-
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
E
L
--
D
M
F
S
A
----
A
L
P
D
D
L
K
E
I
H
I
----
W
I
S
F
S
H
M
--
D
T
D
--
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
Y
-----
M
S
H
P
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
-----
K
-
C
R
-
P
E
-
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
E
-
L
-
L
--
P
K
E
A
V
-
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
---
K
G
---
M
S
I
------
A
E
I
----
T
----
R
--------
Q
-----------
Q
P
D
---
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
-
E
P
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
---
F
Q
N
V
I
Y
M
G
T
F
S
K
S
L
L
-
P
G
L
R
I
S
Y
M
V
L
P
P
-
E
-----
L
L
R
A
Y
K
Q
R
---
G
Y
D
L
Q
T
C
S
-
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
-
Y
Q
-
K
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
-
E
A
E
F
---
S
-
G
E
V
T
V
K
--
G
A
N
A
G
L
H
F
V
T
E
-
D
T
R
-
R
-----
T
E
Q
D
I
L
S
H
A
A
-
G
L
Q
L
E
I
F
G
M
S
R
F
--------------------
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
------------------
51
HHSearch
50.15
20%
-111
- C3 -
1VP4
16
?
A:
[41-422]
---------------------------------------------------------------------------------------------------------
A
D
K
D
A
I
S
F
G
G
G
V
P
D
P
E
--
T
F
P
R
K
E
L
A
E
I
A
K
E
I
I
E
K
E
Y
H
Y
T
L
Q
Y
S
T
T
E
G
D
P
V
L
K
Q
Q
I
L
K
L
L
E
R
M
Y
G
I
-----
T
G
L
D
-
E
D
-
N
L
I
F
T
V
G
S
Q
Q
A
L
D
L
I
G
K
L
F
-
L
--
D
D
E
S
Y
-
C
V
L
D
D
P
A
Y
L
G
A
I
N
A
F
R
Q
Y
L
A
N
F
V
V
V
P
L
E
D
---
D
G
---
M
D
L
------
N
V
L
----
E
R
K
L
-
S
E
F
D
K
N
GKI
K
-----------
Q
V
K
---
F
I
Y
V
V
S
N
F
H
N
P
A
G
V
T
T
S
L
E
K
R
K
A
L
V
E
I
A
E
K
-
Y
-
D
L
F
I
V
E
D
D
P
Y
G
A
L
R
Y
E
G
E
T
V
D
P
I
F
K
I
G
---
G
---
P
E
R
V
V
L
L
N
T
F
S
K
V
L
A
-
P
G
L
R
I
G
M
V
A
G
S
K
-
E
-----
F
I
R
K
I
V
Q
A
--
K
Q
S
A
D
L
C
S
P
-
A
I
T
H
R
L
A
A
R
Y
L
E
R
Y
D
-
L
L
-
E
Q
L
K
P
T
I
E
L
Y
R
R
K
R
T
V
M
L
N
A
L
-
E
E
Y
F
SDI
P
-
G
-
V
K
W
V
--
K
S
E
G
G
L
F
I
W
L
T
L
P
E
G
-
F
-----
D
T
W
E
M
F
E
Y
A
K
-
R
K
K
V
F
Y
V
P
G
R
V
F
K
V
Y
D
E
--------------
P
S
P
S
M
R
L
S
F
C
L
P
P
D
E
K
I
V
E
G
I
K
R
L
R
E
V
V
--
L
E
Y
G
K
E
K
----
16
PsiBlast_PDB
47.79
21%
-102
- C3 -
1VP4
16
?
A:
[44-422]
------------------------------------------------------------------------------------------------------------
D
A
I
S
F
G
G
G
V
P
D
P
E
--
T
F
P
R
K
E
L
A
E
I
A
K
E
I
I
E
K
E
Y
H
Y
T
L
Q
Y
S
T
T
E
G
D
P
V
L
K
Q
Q
I
L
K
L
L
E
R
M
Y
G
I
-----
T
-
G
L
-
D
E
D
N
L
I
F
T
V
G
S
Q
Q
A
L
D
L
I
G
K
-
L
F
L
--
D
D
E
S
Y
-
C
V
L
D
D
P
A
Y
L
G
A
I
N
A
F
R
Q
Y
L
A
N
F
V
V
V
P
L
E
D
---
D
G
---
M
D
L
------
N
V
L
----
E
----
R
--------
K
L
S
E
F
D
K
N
GKIK
Q
V
K
---
F
I
Y
V
V
S
N
F
H
N
P
A
G
V
T
T
S
L
E
K
R
K
A
L
V
E
-
I
A
E
K
Y
-
D
L
F
I
V
E
D
D
P
Y
G
A
L
R
Y
E
G
E
T
V
D
P
I
F
K
I
G
---
G
---
P
E
R
V
V
L
L
N
T
F
S
K
V
L
A
-
P
G
L
R
I
G
M
V
A
G
S
K
-
E
-----
F
I
R
K
I
-
V
Q
--
A
K
Q
S
A
D
L
C
S
P
A
I
T
H
R
L
A
A
R
Y
L
E
R
Y
D
-
L
L
-
E
Q
L
K
P
T
I
E
L
Y
R
R
K
R
T
V
M
L
N
A
L
E
E
Y
F
S
---
D
-
I
-
P
G
V
K
W
V
K
S
E
G
G
L
F
I
W
L
T
L
P
E
G
-
F
-----
D
T
W
E
M
F
E
Y
A
K
-
R
K
K
V
F
Y
V
P
G
R
V
F
K
V
Y
D
E
----------
P
S
P
S
M
R
----
L
S
F
C
L
P
P
D
E
K
I
V
E
G
I
K
R
L
R
E
V
V
L
E
Y
G
K
E
K
------
53
HHSearch
46.92
24%
-95
- C3 -
3AOW
4
?
A:
[74-446]
---------------------------------------------------------------------------------------------------------
E
T
S
D
I
I
S
L
A
G
G
L
P
N
P
K
--
T
F
P
K
E
I
I
R
D
I
L
V
E
I
M
E
K
Y
A
D
K
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
G
K
R
Y
G
I
-----
S
-
Q
--
D
N
-
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
-
L
--
N
P
G
D
I
-
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
---
E
G
---
M
K
V
------
E
I
L
----
E
E
K
L
-
K
E
L
K
S
Q
G--
K
-----------
K
V
K
---
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
-
Y
-
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
E
K
K
I
K
A
L
D
---
N
---
E
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
-
P
G
F
R
I
G
W
M
V
G
D
P
-
G
-----
I
I
R
K
M
E
I
A
--
K
Q
S
T
D
L
C
T
N
-
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
-
L
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
-
E
E
F
M
P--
E
-
G
-
V
K
W
T
--
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
-
I
-----
D
S
K
K
M
L
E
R
A
I
-
K
K
G
V
A
Y
V
P
G
E
A
F
Y
A
H
R
D
--------------
V
K
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
--
K
E
E
L
-------
63
HHSearch
46.78
25%
-103
- C3 -
2ZYJ
2
LYSN_THET2
A:
[30-395]
---------------------------------------------------------------------------------------------------------
Q
R
P
G
I
L
S
F
A
G
G
L
P
A
P
E
--
L
F
P
K
E
E
A
A
E
A
A
A
R
I
L
R
E
K
G
E
V
A
L
Q
Y
S
P
T
E
G
Y
A
P
L
R
A
F
V
A
E
W
I
----
G
--------
V
R
-
P
E
-
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
F
-
L
--
D
E
G
S
P
-
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
---
E
G
---
P
D
L
------
D
A
L
----
E
E
V
L
K
R
--------
E
-----------
R
P
R
---
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
-
R
-
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
R
L
P
S
L
F
E
L
A
R
E
A
G
---
Y
P
G
V
I
Y
L
G
S
F
S
K
V
L
S
-
P
G
L
R
V
A
F
A
V
A
H
P
-
E
-----
A
L
Q
K
L
V
Q
A
--
K
Q
G
A
D
L
H
T
P
-
M
L
N
Q
M
L
V
H
E
L
L
K
E
G
--
F
S
-
E
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
-
D
R
E
V
---
P
K
E
-
V
R
Y
T
--
R
P
K
G
G
M
F
V
W
M
E
L
P
K
G
-
L
-----
S
A
E
G
L
F
R
R
A
L
-
E
E
N
V
A
F
V
P
G
G
P
F
F
A
N
G
G
--------------
G
E
N
T
L
R
L
S
Y
A
T
L
D
R
E
G
I
A
E
G
V
R
R
L
G
R
A
L
--
K
G
L
L
A
------
58
HHSearch
46.68
22%
-104
* C3 *
2ZC0
4
?
A:
[32-405]
---------------------------------------------------------------------------------------------------------
K
G
V
K
L
I
S
L
A
A
G
D
P
D
P
E
--
L
I
P
R
A
V
L
G
E
I
A
K
E
V
L
E
K
E
-
P
K
S
V
M
Y
T
P
A
N
G
I
P
E
L
R
E
E
L
A
A
F
L
K
K
Y
D
H
L
-----
E
-
V
S
-
P
E
-
N
I
V
I
T
I
G
G
T
G
A
L
D
L
L
G
R
V
L
-
I
--
D
P
G
D
V
-
V
I
T
E
N
P
S
Y
I
N
T
L
L
A
F
E
Q
L
G
A
K
I
E
G
V
P
V
D
N
---
D
G
---
M
R
V
------
D
L
L
----
E
E
K
I
-
K
E
L
K
A
K
G--
Q
-----------
K
V
K
---
L
I
Y
T
I
P
T
G
Q
N
P
M
G
V
T
M
S
M
E
R
R
K
A
L
L
E
I
A
S
K
-
Y
-
D
L
L
I
I
E
D
T
A
Y
N
F
M
R
Y
E
G
G
D
I
V
P
L
K
A
L
D
---
N
---
E
G
R
V
I
V
A
G
T
L
S
K
V
L
G
-
T
G
F
R
I
G
W
I
I
A
E
G
-
E
-----
I
L
K
K
V
L
M
Q
--
K
Q
P
I
D
F
C
A
P
-
A
I
S
Q
Y
I
A
L
E
Y
L
K
R
G
Y
-
F
E
K
Y
H
L
E
G
A
L
L
G
Y
K
E
K
R
D
I
M
L
K
A
L
-
E
N
H
L
---
P
-
N
-
A
E
F
T
--
K
P
I
A
G
M
F
V
M
F
F
L
P
E
G
-
A
-----
D
G
I
S
F
A
N
E
L
M
E
R
E
G
V
V
V
V
P
G
K
P
F
Y
T
D
E
S
--------------
G
K
N
A
I
R
L
N
F
S
R
P
S
K
E
E
I
P
I
G
I
K
K
L
A
K
L
Y
--
K
E
K
F
-------
3
PsiBlast_PDB
43.85
24%
-99
- C3 -
1WST
1
?
A:
[38-408]
--------------------------------------------------------------------------------------------------------
V
E
T
S
D
V
I
S
L
A
G
G
L
P
A
P
E
--
T
F
P
V
E
T
I
K
K
I
A
V
E
V
L
E
E
H
A
D
K
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
L
A
L
A
R
W
M
E
K
R
Y
D
I
-----
P
-
M
S
-
K
V
-
E
I
M
T
V
A
G
S
Q
Q
A
L
D
L
I
G
R
-
V
-
F
LN
P
G
D
P
I
--
V
V
E
A
P
T
Y
L
A
A
I
Q
A
F
K
Y
Y
D
P
E
F
I
S
I
P
L
D
D
---
K
G
---
M
R
V
D
L
L
E
E
K
L
E
E
----
L
----
R
--------
K
-----------
Q
G
K
RVK
I
V
Y
T
V
S
T
F
Q
N
P
A
G
V
T
M
S
V
D
R
R
K
K
L
L
E
L
A
N
E
Y
--
D
F
L
I
V
E
D
G
P
Y
S
E
L
R
Y
S
G
E
P
T
P
P
I
K
H
F
D
---
D
---
Y
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
-
P
G
F
R
I
G
W
V
A
A
H
P
-
H
-----
L
I
R
K
M
-
E
I
--
A
K
Q
S
I
D
L
C
T
N
T
F
G
Q
A
I
A
W
K
Y
V
E
N
G
Y
-
L
D
-
E
H
I
P
K
I
I
E
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
Y
M
P
---
E
-
G
-
V
E
W
T
--
K
P
E
G
G
M
F
V
R
V
T
L
P
E
G
-
I
-----
D
T
K
L
M
M
E
R
A
V
-
A
K
G
V
A
Y
V
P
G
E
A
F
F
V
H
R
D
----------
K
K
N
T
M
R
----
L
N
F
T
Y
V
P
E
E
T
I
R
E
G
V
R
R
L
A
E
T
I
-------------
54
HHSearch
42.52
17%
-104
- C3 -
1GD9
2
?
A:
[25-386]
----------------------------------------------------------------------------------------------------------
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
--
T
--
P
Q
H
I
K
E
Y
A
K
E
A
L
D
---
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
-----
E
-
A
D
P
K
T
-
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
-
L
--
K
D
G
E
E
-
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
EDE
F
R
---
L
N
V
------
D
E
L
----
K
K
Y
V-
T
--------
D
-----------
K
T
R
---
A
L
I
I
N
-
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
-
H
-
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
D
G--
M
---
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
-
W
-----
I
I
E
R
M
V
K
F
--
Q
M
Y
N
A
T
C
P
V
-
T
F
I
Q
Y
A
A
A
K
A
L
K
D
E
R
-
S
W
-
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
-
N
E
M
------
G
-
L
P
T
V
--
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
G
L
-----
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
----------------
G
E
G
Y
V
R
I
S
Y
A
T
A
-
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
--
K
E
R
--------
8
PsiBlast_PDB
42.37
28%
-101
- C3 -
2ZYJ
2
LYSN_THET2
A:
[87-392]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-----
G
-
V
R
-
P
E
-
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
-
V
-
F
--
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
---
E
G
---
P
D
L
------
D
A
L
E
E
V
L
K
----
R
--------
E
-----------
R
P
R
---
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
R
--
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
R
L
P
S
L
F
E
L
A
---
R
E
A
G
Y
P
G
V
I
Y
L
G
S
F
S
K
V
L
S
-
P
G
L
R
V
A
F
A
V
A
H
P
-
E
-----
A
L
Q
K
L
-
V
Q
A
K
Q
G
A
D
L
H
T
-
P
-
M
L
N
Q
M
L
V
H
E
L
L
K
E
G
--
F
S
-
E
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
---
K
-
E
-
V
R
Y
T
--
R
P
K
G
G
M
F
V
W
M
E
L
P
K
-------------------
G
L
S
A
E
--
G
L
F
R
R
A
L
E
E
N
V
A
F
V
P
GGPFF
A
N
G
G
G
E
N
T
L
R
L
S
Y
A
T
L
D
R
E
G
I
A
E
G
V
R
R
L
G
R
A
L
--
K
G
---------
55
HHSearch
42.16
11%
-116
- C3 -
4IX8
2
?
A:
[65-443]
---------------------------------------------------------------------------------------------------------
S
T
K
S
N
L
R
L
S
I
G
D
P
T
V
D
GN
L
K
T
P
D
I
V
T
E
A
M
V
D
V
V
R
S
--
G
K
F
N
G
Y
P
P
T
V
G
A
D
N
L
R
Q
V
V
S
T
Y
W
R
R
F
C
Q
T
K
S
R
Q
E
A
-
L
K
-
W
E
-
N
V
I
I
T
S
G
V
S
Q
A
I
V
L
A
L
T
A
L
-
C
--
N
E
G
D
N
-
I
L
V
C
A
P
S
F
P
H
Y
K
S
V
C
D
S
Y
G
I
E
C
R
Y
Y
Y
L
D
P
---
S
K
SWE
C
D
L
------
R
A
A
----
A
G
M
V-
D
--------
S
-----------
H
T
K
---
A
F
V
I
I
-
N
P
S
N
P
C
G
S
N
F
S
R
A
H
V
S
D
I
I
D
F
C
Q
Q
-
H
-
Q
I
P
L
I
S
D
E
I
Y
A
E
M
V
L
N
N
G
I
F
T
S
V
A
D
F
D
---
T
---
N
V
P
R
L
I
L
G
G
T
A
K
Y
Q
V
C
P
G
W
R
V
G
W
S
I
L
I
D
P
M
NV
A
G
D
W
A
V
G
M
E
R
L
--
T
Q
-
L
I
A
G
V
N
-
S
I
C
Q
E
A
I
A
R
T
L
L
K
C
P
--
T
-
E
C
T
E
H
I
V
T
Q
L
E
A
G
A
K
V
Y
A
R
L
L
-
E
H
D
----
I
-
G
-
I
S
M
E
--
A
P
Q
A
S
M
F
V
M
L
K
L
N
L
S
-
Y
FQDLK
S
D
M
E
F
Y
E
K
L
L
D
E
E
N
V
Q
V
L
P
G
E
I
F
G
M
------------------
S
G
F
L
R
A
T
V
S
R
P
-
S
A
V
L
N
E
A
V
D
R
I
I
E
F
C
--
E
R
H
K
-------
59
HHSearch
42.14
16%
-98
- C3 -
1B5P
3
AAT_THET8
A:
[29-382]
---------------------------------------------------------------------------------------------------------
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
----
T
P
E
H
V
K
E
A
A
R
R
A
L
A
---
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
-----
S
-
V
T
-
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
-
L
--
D
P
G
D
E
-
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E--
E
G
FV-
P
D
P
------
E
R
V
----
R
R
A
I-
T
--------
P
-----------
R
T
K
---
A
L
V
V
N
-
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
-
H
-
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
-
H
F
S
P
G
R
V
----
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
-
E
-----
V
I
K
A
M
A
S
V
--
S
R
Q
S
T
T
S
P
D
-
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
S
R
-
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
-
T
A
L
------
G
-
L
K
A
V
--
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-----
D
E
V
R
A
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
A
------------------
F
G
H
V
R
L
S
Y
A
T
-
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-------------