@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu10920: (2016-06-17 )
MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIGGYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGVTYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSFEQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGETKSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTHFIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPHSPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ
Atome Classification :
(24 SA)
.........10....-.--....20.----------.......---------.------30...-------.....40........50........60........70........80....--.--..--.90......----.--.---100.-.......110...---....120---.......130.......-140-........150.-....--.-.-.160.......170.......180.......190...-....200...--.--..-.210.......220.......230.......240.......250.......260.......270.......280.....------.------.290.......-300.-......310.......320.......330.-...-..-.340.......-350.......360.......370---.......380---.----.......------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNGNEPHG
G
V
-
L
I
NR-C--DPACH-F----------EGC
A
C
Q
A
---------
E
------
L
D
Q
L
A
-------LSD
L
E
L
I
A
IGGY
S
P
L
T
G
FLG
E
K
D
Y
H
S
V
V
K
E
M
R
L
ANGLPWS
L
P
I
T
L
PVG
E
K
T
--
A
--
R
Q--LSAGD
H
V
K
L
----V--K---DG-
V
-
T
Y
G
M
I
T
V
T
DIYQP---D
K
T
Q
E
A
L
---
S
V
FKTNDPAH
P
G
V
K
K
L
L-A-R-P
D
Y
YIGG
P
I
-
T
V-SSLP--
D
-
K
-
S
F
E
Q
F
YAT
P
A
E
T
R
A
A
F
Q
KLG
W
K
T
I
V
GFQTRN
P
V
H
R
A
H
-
E
Y
I
Q
K
T
A
L
E
T
--
V
--
D
G
-
L
L
LHPLVGETKSDDI
P
S
D
I
R
M
E
S
Y
Q
A
L
L
N
HYYPKDR
V
M
L
S
V
F
P
A
A
M
RYAG
P
R
E
A
I
F
H
A
L
V
R
KNYGC
T
H
F
I
VGRDHAGVG------S------YYGTY
D
A
Q
N
I
F
-
Q
S
F
T
-
E
E
ELGIK
P
L
F
FEHS
F
Y
C
R
K
CGNMGTSKTCP-HSP-R
D
-
H
I
HL
S
G
T
K
V
R
E
-
L
L
RQGKKP
P
K
EFSR
P
E
V
A
A
V
L
I
K---GLHQQP
V
A
I
----K----QNSGELQ------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
89.55
40%
0
- C- -
1J70
1
MET3_YEAST
B:
[7-387]
-----
P
H
G
G
I
-
L
Q
D
L
-
I
AR
D
A
L
K
K
-
N
----------
E
L
L
S
E
A
Q
---------
S
------
S
D
I
L
V
WNLTPRQ
L
C
D
I
E
L
I
L
N
G
G
F
S
P
L
T
G
F
L
N
E
N
D
Y
S
S
V
V
T
D
S
R
L
A
D
G
T
L
W
T
I
P
I
T
L
D
V
D
E
A
F
--
A
--
N
Q
--
I
K
P
D
T
R
I
A
L
----
F
--
Q
---
D
D
E
I
-
P
I
A
I
L
T
V
Q
D
V
Y
K
P
---
N
K
T
I
E
A
E
---
K
V
F
R
-
G
D
P
E
H
P
A
I
S
Y
L
F
N
V
-
A
-
G
D
Y
Y
V
G
G
S
L
-
E
A
-
I
Q
L
P
--
Q
-
H
Y
D
Y
P
G
L
R
K
T
P
A
Q
L
R
L
E
F
Q
S
R
Q
W
D
R
V
V
A
F
Q
T
R
N
P
M
H
R
A
H
R
E
L
T
V
R
A
A
R
E
A
--
N
--
A
K
-
V
L
I
H
P
V
V
G
L
T
K
P
G
D
I
D
H
H
T
R
V
R
V
Y
Q
E
I
I
K
R
-
Y
P
N
G
I
A
F
L
S
L
L
P
L
A
M
R
M
S
G
D
R
E
A
V
W
H
A
I
I
R
K
N
Y
G
A
S
H
F
I
V
G
R
D
H
A
G
P
G
KNSKGV
D
------
F
Y
G
P
Y
D
A
Q
E
L
V
-
E
S
Y
--
K
H
E
L
D
I
E
V
V
P
F
R
M
V
T
Y
L
P
D
E
D
R
Y
A
P
I
D
Q
I
D
-
T
T
K
-
T
R
-
T
L
N
I
S
G
T
E
L
R
R
-
R
L
R
V
G
G
E
I
P
E
W
F
S
Y
P
E
V
V
K
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
89.55
40%
0
- C- -
1J70
2
MET3_YEAST
C:
[7-387]
-----
P
H
G
G
I
-
L
Q
D
L
-
I
AR
D
A
L
K
K
-
N
----------
E
L
L
S
E
A
Q
---------
S
------
S
D
I
L
V
WNLTPRQ
L
C
D
I
E
L
I
L
N
G
G
F
S
P
L
T
G
F
L
N
E
N
D
Y
S
S
V
V
T
D
S
R
L
A
D
G
T
L
W
T
I
P
I
T
L
D
V
D
E
A
F
--
A
--
N
Q
--
I
K
P
D
T
R
I
A
L
----
F
--
Q
---
D
D
E
I
-
P
I
A
I
L
T
V
Q
D
V
Y
K
P
---
N
K
T
I
E
A
E
---
K
V
F
R
-
G
D
P
E
H
P
A
I
S
Y
L
F
N
V
-
A
-
G
D
Y
Y
V
G
G
S
L
-
E
A
-
I
Q
L
P
--
Q
-
H
Y
D
Y
P
G
L
R
K
T
P
A
Q
L
R
L
E
F
Q
S
R
Q
W
D
R
V
V
A
F
Q
T
R
N
P
M
H
R
A
H
R
E
L
T
V
R
A
A
R
E
A
--
N
--
A
K
-
V
L
I
H
P
V
V
G
L
T
K
P
G
D
I
D
H
H
T
R
V
R
V
Y
Q
E
I
I
K
R
-
Y
P
N
G
I
A
F
L
S
L
L
P
L
A
M
R
M
S
G
D
R
E
A
V
W
H
A
I
I
R
K
N
Y
G
A
S
H
F
I
V
G
R
D
H
A
G
P
G
KNSKGV
D
------
F
Y
G
P
Y
D
A
Q
E
L
V
-
E
S
Y
--
K
H
E
L
D
I
E
V
V
P
F
R
M
V
T
Y
L
P
D
E
D
R
Y
A
P
I
D
Q
I
D
-
T
T
K
-
T
R
-
T
L
N
I
S
G
T
E
L
R
R
-
R
L
R
V
G
G
E
I
P
E
W
F
S
Y
P
E
V
V
K
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
89.55
40%
0
- C- -
1J70
3
MET3_YEAST
A:
[7-387]
-----
P
H
G
G
I
-
L
Q
D
L
-
I
A
R
D
A
L
K
K
-
N
----------
E
L
L
S
E
A
Q
---------
S
------
S
D
I
L
V
W
N
L
T
P
R
Q
L
C
D
I
E
L
I
L
N
G
G
F
S
P
L
T
G
F
L
N
E
N
D
Y
S
S
V
V
T
D
S
R
L
A
D
G
T
L
W
T
I
P
I
T
L
D
V
D
E
A
F
--
A
--
N
Q
--
I
K
P
D
T
R
I
A
L
----
F
--
Q
---
D
D
E
I
-
P
I
A
I
L
T
V
Q
D
V
Y
K
P
---
N
K
T
I
E
A
E
---
K
V
F
R
-
G
D
P
E
H
P
A
I
S
Y
L
F
N
V
-
A
-
G
D
Y
Y
V
G
G
S
L
-
E
A
-
I
Q
L
P
--
Q
-
H
Y
D
Y
P
G
L
R
K
T
P
A
Q
L
R
L
E
F
Q
S
R
Q
W
D
R
V
V
A
F
Q
T
R
N
P
M
H
R
A
H
R
E
L
T
V
R
A
A
R
E
A
--
N
--
A
K
-
V
L
I
H
P
V
V
G
L
T
K
P
G
D
I
D
H
H
T
R
V
R
V
Y
Q
E
I
I
K
R
-
Y
P
N
G
I
A
F
L
S
L
L
P
L
A
M
R
M
S
G
D
R
E
A
V
W
H
A
I
I
R
K
N
Y
G
A
S
H
F
I
V
G
R
D
H
A
G
P
G
KNSKGV
D
------
F
Y
G
P
Y
D
A
Q
E
L
V
-
E
S
Y
--
K
H
E
L
D
I
E
V
V
P
F
R
M
V
T
Y
L
P
D
E
D
R
Y
A
P
I
D
Q
I
D
-
T
T
K
-
T
R
-
T
L
N
I
S
G
T
E
L
R
R
-
R
L
R
V
G
G
E
I
P
E
W
F
S
Y
P
E
V
V
K
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
89.30
42%
-94
- C4 -
1M8P
-
MET3_PENCH
A:
[2-391]
--
A
N
A
P
H
G
G
V
-
L
K
D
L
-
L
--
A
R
D
A
P
-
R
Q
A
E
L
A
A
E
A
--
E
S
L
-
P
A
V
---------
T
------
L
T
E
R
Q
-------
L
C
D
L
E
L
I
M
N
G
G
F
S
P
L
E
G
F
M
N
Q
A
D
Y
D
R
V
C
E
D
N
R
L
A
D
G
N
V
F
S
M
P
I
T
L
D
A
S
Q
E
V
--
I
D
E
K
K
--
L
Q
A
A
S
R
I
T
L
----
R
--
D
FR-
D
D
-
R
-
N
L
A
I
L
T
I
D
D
I
Y
R
P
---
D
K
T
K
E
A
K
---
L
V
F
G
G
-
D
P
E
H
P
A
I
V
Y
L
N
-
N
T
V
-
K
E
F
Y
I
G
G
K
I
-
E
A
-
V
N
K
L
--
N
H
Y
-
D
Y
V
A
L
R
Y
T
P
A
E
L
R
V
H
F
D
K
L
G
W
S
R
V
V
A
F
Q
T
R
N
P
M
H
R
A
H
-
R
E
L
T
V
R
A
A
R
S
R
-
Q
--
A
N
-
V
L
I
H
P
V
V
G
L
T
K
P
G
D
I
D
H
F
T
R
V
R
A
Y
Q
A
L
L
P
R
Y
-
P
N
G
M
A
V
L
G
L
L
G
L
A
M
R
M
G
G
P
R
E
A
I
W
H
A
I
I
R
K
N
H
G
A
T
H
F
I
V
G
R
D
H
A
G
P
G
SNSKGE
D
------
F
Y
G
P
Y
D
A
Q
H
A
V
-
E
K
Y
K
--
D
E
L
G
I
E
V
V
E
F
Q
M
V
T
Y
L
P
D
T
D
E
Y
R
P
V
D
Q
V
P
-
A
G
--
V
K
-
T
L
N
I
S
G
T
E
L
R
R
-
R
L
R
S
G
A
H
I
P
E
W
F
S
Y
P
E
V
V
K
I
L
R
E
---
S
N
P
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
88.96
41%
-97
- C4 -
1M8P
-
MET3_PENCH
A:
[2-385]
--
A
N
A
P
H
G
G
V
-
L
K
D
L
L
A
--
R
D
A
P
R
-
Q
----------
A
E
L
A
A
E
A
---------
E
SLP
A
V
T
L
T
E
R
Q
-------
L
C
D
L
E
L
I
M
N
G
G
F
S
P
L
E
G
F
M
N
Q
A
D
Y
D
R
V
C
E
D
N
R
L
A
D
G
N
V
F
S
M
P
I
T
L
D
A
S
Q
E
V
I
D
E
--
K
K
--
L
Q
A
A
S
R
I
T
L
R
D
--
F
--
R
---
D
D
-
R
-
N
L
A
I
L
T
I
D
D
I
Y
R
P
---
D
K
T
K
E
A
K
---
L
V
F
G
-
G
D
P
E
H
P
A
I
V
Y
L
N
N
T
-
V
-
K
E
F
Y
I
G
G
K
I
E
A
V
-
N
K
L
N
--
H
-
Y
-
D
Y
V
A
L
R
Y
T
P
A
E
L
R
V
H
F
D
K
L
G
W
S
R
V
V
A
F
Q
T
R
N
P
M
H
R
A
H
R
E
L
T
V
R
A
A
R
S
R
--
Q
--
A
N
-
V
L
I
H
P
V
V
G
L
T
K
P
G
D
I
D
H
F
T
R
V
R
A
Y
Q
A
L
L
P
R
Y
-
P
N
G
M
A
V
L
G
L
L
G
L
A
M
R
M
G
G
P
R
E
A
I
W
H
A
I
I
R
K
N
H
G
A
T
H
F
I
V
G
R
D
H
A
G
P
G
------
S
NSKGED
F
Y
G
P
Y
D
A
Q
H
A
V
-
E
K
Y
--
K
D
E
L
G
I
E
V
V
E
F
Q
M
V
T
Y
L
P
D
T
D
E
Y
R
P
V
D
Q
V
P
-
A
G
V
-
K
T
--
L
N
I
S
G
T
E
L
R
R
-
R
L
R
S
G
A
H
I
P
E
W
F
S
Y
P
E
V
V
K
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
88.48
41%
-94
- C4 -
1I2D
1
MET3_PENCH
C:
[2-385]
--
A
N
A
P
H
G
G
V
-
L
K
D
L
L
A
--
R
D
A
P
R
-
Q
----------
A
E
L
A
A
E
A
---------
E
SLPAVT
L
T
E
R
Q
-------
L
C
D
L
E
L
I
M
N
G
G
F
S
P
L
E
G
F
M
N
Q
A
D
Y
D
R
V
C
E
D
N
R
L
A
D
G
N
V
F
S
M
P
I
T
L
D
A
S
Q
E
V
ID
E
--
K
K
--
L
Q
A
G
S
R
I
T
L
RD--
F
--
R
---
D
D
-
R
-
N
L
A
I
L
T
I
D
D
I
Y
R
P
---
D
K
T
K
E
A
K
---
L
V
F
G
-
G
D
P
E
H
P
A
I
V
Y
L
N
N
T
-
V
-
K
E
F
Y
I
G
G
K
I
E
A
V
-
N
K
L
N
--
H
-
Y
-
D
Y
V
A
L
R
Y
T
P
A
E
L
R
V
H
F
D
K
L
G
W
S
R
V
V
A
F
Q
T
R
N
P
M
H
R
A
H
R
E
L
T
V
R
A
A
R
S
R
--
Q
--
A
N
-
V
L
I
H
P
V
V
G
L
T
K
P
G
D
I
D
H
F
T
R
V
R
A
Y
Q
A
L
L
P
R
Y
-
P
N
G
M
A
V
L
G
L
L
G
L
A
M
R
M
G
G
P
R
E
A
I
W
H
A
I
I
R
K
N
H
G
A
T
H
F
I
V
G
R
D
H
A
G
P
G
------
S
NSKGED
F
Y
G
P
Y
D
A
Q
H
A
V
-
E
K
Y
--
K
D
E
L
G
I
E
V
V
E
F
Q
M
V
T
Y
L
P
D
T
D
E
Y
R
P
V
D
Q
V
P
-
A
G
V
-
K
T
--
L
N
I
S
G
T
E
L
R
R
-
R
L
R
S
G
A
H
I
P
E
W
F
S
Y
P
E
V
V
K
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
87.83
41%
-93
- C4 -
1I2D
1
MET3_PENCH
B:
[2-385]
--
A
N
A
P
H
G
G
V
-
L
K
D
L
L
A
--
R
D
A
P
R
-
Q
----------
A
E
L
A
A
E
A
---------
E
SLPAVT
L
T
E
R
Q
-------
L
C
D
L
E
L
I
M
N
G
G
F
S
P
L
E
G
F
M
N
Q
A
D
Y
D
R
V
C
E
D
N
R
L
A
D
G
N
V
F
S
M
P
I
T
L
D
A
S
Q
E
V
ID
E
--
K
K
--
L
Q
A
G
S
R
I
T
L
RD--
F
--
R
---
D
D
-
R
-
N
L
A
I
L
T
I
D
D
I
Y
R
P
---
D
K
T
K
E
A
K
---
L
V
F
G
-
G
D
P
E
H
P
A
I
V
Y
L
N
N
T
-
V
-
K
E
F
Y
I
G
G
K
I
E
A
V
-
N
K
L
N
--
H
-
Y
-
D
Y
V
A
L
R
Y
T
P
A
E
L
R
V
H
F
D
K
L
G
W
S
R
V
V
A
F
Q
T
R
N
P
M
H
R
A
H
R
E
L
T
V
R
A
A
R
S
R
--
Q
--
A
N
-
V
L
I
H
P
V
V
G
L
T
K
P
G
D
I
D
H
F
T
R
V
R
A
Y
Q
A
L
L
P
R
Y
-
P
N
G
M
A
V
L
G
L
L
G
L
A
M
R
M
G
G
P
R
E
A
I
W
H
A
I
I
R
K
N
H
G
A
T
H
F
I
V
G
R
D
H
A
G
P
G
------
S
NSKGED
F
Y
G
P
Y
D
A
Q
H
A
V
-
E
K
Y
--
K
D
E
L
G
I
E
V
V
E
F
Q
M
V
T
Y
L
P
D
T
D
E
Y
R
P
V
D
Q
V
P
-
A
G
V
-
K
T
--
L
N
I
S
G
T
E
L
R
R
-
R
L
R
S
G
A
H
I
P
E
W
F
S
Y
P
E
V
V
K
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
87.64
41%
-94
- C4 -
1G8F
22
MET3_YEAST
A:
[2-392]
---
P
A
P
H
G
G
I
-
L
Q
D
L
-
I
--
A
R
D
A
L
-
K
K
N
E
L
L
S
E
A
Q
S
S
D
I
-
L
V
W
---------
N
------
L
T
P
R
Q
-------
L
C
D
I
E
L
I
L
N
G
G
F
S
P
L
T
G
F
L
N
E
N
D
Y
S
S
V
V
T
D
S
R
L
A
D
G
T
L
W
T
I
P
I
T
L
D
V
D
E
A
F
--
A
--
N
Q
--
I
K
P
D
T
R
I
A
L
----
F
--
Q
D--
D
E
-
I
-
P
I
A
I
L
T
V
Q
D
V
Y
K
P
---
N
K
T
I
E
A
E
---
R
V
F
R
G
D
-
P
E
H
P
A
I
S
Y
L
F
-
N
V
A
-
G
D
Y
Y
V
G
G
S
L
-
E
A
-
I
Q
L
P
--
Q
H
Y
-
D
Y
P
G
L
R
K
T
P
A
Q
L
R
L
E
F
Q
S
R
Q
W
D
R
V
V
A
F
Q
T
R
N
P
M
H
R
A
H
-
R
E
L
T
V
R
A
A
R
E
A
-
N
--
A
K
-
V
L
I
H
P
V
V
G
L
T
K
P
G
D
I
D
H
H
T
R
V
R
V
Y
Q
E
I
I
K
R
Y
-
P
N
G
I
A
F
L
S
L
L
P
L
A
M
R
M
S
G
D
R
E
A
V
W
H
A
I
I
R
K
N
Y
G
A
S
H
F
I
V
G
R
D
H
A
G
P
G
KNSKGV
D
------
F
Y
G
P
Y
D
A
Q
E
L
V
-
E
S
Y
K
--
H
E
L
D
I
E
V
V
P
F
R
M
V
T
Y
L
P
D
E
D
R
Y
A
P
I
D
Q
I
D
-
T
T
K
-
T
R
-
T
L
N
I
S
G
T
E
L
R
R
-
R
L
R
V
G
G
E
I
P
E
W
F
S
Y
P
E
V
V
K
I
L
R
E
---
S
N
P
P
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
87.43
42%
-105
- C4 -
1V47
9
?
A:
[4-348]
-------------------------------------
T
L
-
P
A
L
---------
E
------
I
G
E
D
E
-------
R
L
D
L
E
N
L
A
T
G
A
F
F
P
V
K
G
F
M
T
R
E
E
A
L
S
V
A
H
E
M
R
L
P
T
G
E
V
W
T
I
P
I
L
L
Q
F
R
E
K
------
P
R
--
V
G
P
G
N
T
V
A
L
----
L
--
H
---
G
G
-
E
-
R
V
A
L
L
H
V
A
E
A
Y
E
L
---
D
L
E
A
L
A
R
---
A
V
F
G
T
D
S
E
T
H
P
G
V
A
R
L
Y
-
G
-
K
-
G
P
Y
A
L
A
G
R
V
-
E
V
-
L
K
P
R
--
P
----
R
T
P
L
E
K
T
P
E
E
V
R
A
F
F
R
Q
R
G
W
R
K
V
V
A
F
Q
T
R
N
A
P
H
R
A
H
-
E
Y
L
I
R
L
G
L
E
L
--
A
--
D
G
-
V
L
V
H
P
I
L
G
A
K
K
P
D
D
F
P
T
E
V
I
V
E
A
Y
Q
A
L
I
R
D
F
L
P
Q
E
R
V
A
F
F
G
L
A
T
P
M
R
Y
A
G
P
K
E
A
V
F
H
A
L
V
R
K
N
F
G
A
T
H
F
L
V
G
R
D
H
A
G
V
G
------
D
------
F
Y
D
P
Y
A
A
H
R
I
F
-
D
R
L
P
---
P
L
G
I
E
I
V
K
V
G
A
V
F
H
C
P
L
C
G
G
I
A
S
E
R
T
C
P
-
E
G
H
R
E
K
-
R
T
A
I
S
M
T
K
V
R
A
-
L
L
R
E
G
K
A
P
P
S
E
L
V
R
P
E
L
L
P
I
L
R
R
---
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
87.31
41%
-92
* C4 *
1R6X
4
MET3_YEAST
A:
[1-386]
---
P
A
P
H
G
G
I
-
L
Q
D
L
-
I
--
A
R
D
A
L
-
K
K
N
E
L
L
S
E
A
Q
S
S
D
I
-
L
V
W
---------
N
------
L
T
P
R
Q
-------
L
C
D
I
E
L
I
L
N
G
G
F
S
P
L
T
G
F
L
N
E
N
D
Y
S
S
V
V
T
D
S
R
L
A
D
G
T
L
W
T
I
P
I
T
L
D
V
D
E
A
F
--
A
--
N
Q
--
I
K
P
D
T
R
I
A
L
----
F
--
Q
D--
D
E
-
I
-
P
I
A
I
L
T
V
Q
D
V
Y
K
P
---
N
K
T
I
E
A
E
---
K
V
F
R
G
D
-
P
E
H
P
A
I
S
Y
L
F
-
N
V
A
-
G
D
Y
Y
V
G
G
S
L
-
E
A
-
I
Q
L
P
--
Q
H
Y
-
D
Y
P
G
L
R
K
T
P
A
Q
L
R
L
E
F
Q
S
R
Q
W
D
R
V
V
A
F
Q
T
R
N
P
M
H
R
A
H
-
R
E
L
T
V
R
A
A
R
E
A
-
N
--
A
K
-
V
L
I
H
P
V
V
G
L
T
K
P
G
D
I
D
H
H
T
R
V
R
V
Y
Q
E
I
I
K
R
Y
-
P
N
G
I
A
F
L
S
L
L
P
L
A
M
R
M
S
G
D
R
E
A
V
W
H
A
I
I
R
K
N
Y
G
A
S
H
F
I
V
G
R
D
H
A
G
P
G
KNSKGV
D
------
F
Y
G
P
Y
D
A
Q
E
L
V
-
E
S
Y
K
--
H
E
L
D
I
E
V
V
P
F
R
M
V
T
Y
L
P
D
E
D
R
Y
A
P
I
D
Q
I
D
-
T
T
K
-
T
R
-
T
L
N
I
S
G
T
E
L
R
R
-
R
L
R
V
G
G
E
I
P
E
W
F
S
Y
P
E
V
V
K
I
L
R
E
---
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
87.19
42%
-90
- C4 -
1I2D
2
MET3_PENCH
A:
[2-573]
--
A
N
A
P
H
G
G
V
-
L
K
D
L
-
L
--
A
R
D
A
P
-
R
----------
Q
A
E
L
A
A
E
A
E
S
L
P
A
V
--
T
------
L
T
E
R
Q
-------
L
C
D
L
E
L
I
M
N
G
G
F
S
P
L
E
G
F
M
N
Q
A
D
Y
D
R
V
C
E
D
N
R
L
A
D
G
N
V
F
S
M
P
I
T
L
D
A
S
Q
E
V
--
I
--
D
E
K
K
L
Q
A
G
S
R
I
T
L
----
R
D
F
R
---
D
D
-
R
-
N
L
A
I
L
T
I
D
D
I
Y
R
P
---
D
K
T
K
E
A
K
---
L
V
F
G
G
-
D
P
E
H
P
A
I
V
Y
L
N
-
N
-
T
V
K
E
F
Y
I
G
G
K
I
-
E
A
V
N
K
L
N
--
H
-
Y
-
D
Y
V
A
L
R
Y
T
P
A
E
L
R
V
H
F
D
K
L
G
W
S
R
V
V
A
F
Q
T
R
N
P
M
H
R
A
H
-
R
E
L
T
V
R
A
A
R
S
--
R
Q-
A
N
-
V
L
I
H
P
V
V
G
L
T
K
P
G
D
I
D
H
F
T
R
V
R
A
Y
Q
A
L
L
P
R
Y
-
P
N
G
M
A
V
L
G
L
L
G
L
A
M
R
M
G
G
P
R
E
A
I
W
H
A
I
I
R
K
N
H
G
A
T
H
F
I
V
G
R
D
H
A
G
P
G
------
S
NSKGED
F
Y
G
P
Y
D
A
Q
H
A
V
-
E
K
Y
--
K
D
E
L
G
I
E
V
V
E
F
Q
M
V
T
Y
L
P
D
T
D
E
Y
R
P
V
D
Q
V
P
-
A
G
--
V
K
-
T
L
N
I
S
G
T
E
L
R
R
-
R
L
R
S
G
A
H
I
P
E
W
F
S
Y
P
E
V
V
K
I
L
R
E
S
NP
P
R
A
T
Q
G
F
T
I
F
L
T
G
Y
----
M
N
S
G
K
D
A
I
A
R
A
L
Q
V
T
L
N
Q
Q
GG
R
S
V
S
L
L
L
G
D
T
V
R
H
E
LSSELGFT
R
E
D
R
H
T
N
I
Q
R
I
A
F
V
A
T
E
L
T
R
A
G
A
A
V
I
A
A
P
IAPY
E
E
S
R
K
F
A
R
D
A
V
S
Q
A
G
S
F
F
L
V
H
VATP
L
E
H
C
E
Q
S
DKRG
I
Y
A
A
A
R
R
GEIKGFTGVDDPYETPEKAD
L
V
V
D
FSKQS
V
R
S
I
V
H
E
I
I
L
V
L
E
S
Q
GFLERQ
40
HHSearch
86.99
37%
-115
- C4 -
4DNX
1
SAT_ALLVD
A:
[1-393]
--
M
I
K
P
V
G
S
D
E
L
R
P
R
-
F
--
V
Y
D
P
E
Q
H
H
R
L
S
S
E
A
---
E
S
L
-
P
S
V
---------
I
------
V
S
S
Q
A
-------
A
G
N
A
V
M
L
G
A
G
Y
F
S
P
L
D
G
F
M
N
L
A
D
A
L
S
S
A
Q
S
M
T
L
T
D
G
R
F
F
P
V
P
L
L
C
L
L
E
S
A
D
------
A
--
I
A
G
A
T
R
I
A
L
----
R
--
D
PNV
E
G
-
N
P
V
L
A
V
M
D
V
T
A
V
E
Q
V
S
D
A
Q
M
A
L
M
T
E
---
Q
V
Y
G
T
S
D
P
K
H
P
G
V
E
T
F
N
-
S
-
Q
-
G
R
T
A
I
S
G
P
I
-
Q
V
-
L
N
F
S
Y-
F
Q
T
-
D
F
P
D
T
F
R
T
A
V
E
I
R
H
E
I
Q
E
R
G
W
Q
K
I
V
A
F
Q
T
R
N
P
M
H
R
A
H
-
E
E
L
C
K
M
A
M
E
A
V
E
A
--
D
G
-
V
V
I
H
M
L
L
G
Q
L
K
P
G
D
I
P
A
P
V
R
D
A
A
I
R
T
M
A
E
L
Y
F
P
P
N
T
V
M
V
T
G
Y
G
F
D
M
L
Y
A
G
P
R
E
A
V
L
H
A
Y
F
R
Q
N
M
G
A
T
H
F
I
I
G
R
D
H
A
G
V
G
------
D
------
Y
Y
G
P
F
D
A
Q
T
I
F
-
D
D
A
V
P
T
D
V
L
A
I
E
I
F
R
A
D
N
T
A
Y
S
K
K
L
G
R
V
V
M
M
R
D
A
P
D
H
T
P
-
D
D
-
F
I
Q
L
S
G
T
R
V
R
E
-
M
L
G
Q
G
E
A
P
P
P
E
F
S
R
P
E
V
A
Q
I
L
M
D
---
Y
Y
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
86.88
41%
-102
- C4 -
2GKS
1
SATC_AQUAE
A:
[5-373]
------------------------------------
K
Y
L
-
K
S
I
---------
Q
------
I
S
Q
R
S
-------
V
L
D
L
E
L
L
A
V
G
A
F
T
P
L
D
R
F
M
G
E
E
D
Y
R
N
V
V
E
S
M
R
L
K
S
G
T
L
F
P
I
P
I
T
L
P
M
E
K
E
I
--
A
--
K
D
--
L
K
E
G
E
W
I
V
L
----
R
--
D
P--
K
N
-
V
-
P
L
A
I
M
R
V
E
E
V
Y
K
W
---
N
L
E
Y
E
A
K
---
N
V
L
G
T
T
D
P
R
H
P
L
V
A
E
M
H
-
T
-
W
-
G
E
Y
Y
I
S
G
E
L
-
K
V
-
I
Q
L
P
--
K
Y
Y
-
D
F
P
E
Y
R
K
T
P
K
Q
V
R
E
E
I
K
S
L
G
L
D
K
I
V
A
F
Q
T
R
N
P
M
H
R
V
H
-
E
E
L
T
K
R
A
M
E
K
V
-
G
--
G
G
-
L
L
L
H
P
V
V
G
L
T
K
P
G
D
V
D
V
Y
T
R
M
R
I
Y
K
V
L
Y
E
K
Y
Y
D
K
K
K
T
I
L
A
F
L
P
L
A
M
R
M
A
G
P
R
E
A
L
W
H
G
I
I
R
R
N
Y
G
A
T
H
F
I
V
G
R
D
H
A
S
P
G
KDSKGK
P
------
F
Y
D
P
Y
E
A
Q
E
L
F
-
K
K
Y
E
--
D
E
I
G
I
K
M
V
P
F
E
E
L
V
Y
V
P
E
L
D
Q
Y
V
E
I
N
------------------
E
I
R
E
N
F
L
K
Q
G
R
K
L
P
E
W
F
T
R
P
E
V
A
E
I
L
A
E
---
T
Y
V
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
86.76
41%
-91
- C4 -
1I2D
1
MET3_PENCH
A:
[2-385]
--
A
N
A
P
H
G
G
V
-
L
K
D
L
L
A
--
R
D
A
P
R
-
Q
----------
A
E
L
A
A
E
A
---------
E
S
L
P
A
V
T
L
T
E
R
Q
-------
L
C
D
L
E
L
I
M
N
G
G
F
S
P
L
E
G
F
M
N
Q
A
D
Y
D
R
V
C
E
D
N
R
L
A
D
G
N
V
F
S
M
P
I
T
L
D
A
S
Q
E
V
I
D
E
--
K
K
--
L
Q
A
G
S
R
I
T
L
R
D
--
F
--
R
---
D
D
-
R
-
N
L
A
I
L
T
I
D
D
I
Y
R
P
---
D
K
T
K
E
A
K
---
L
V
F
G
-
G
D
P
E
H
P
A
I
V
Y
L
N
N
T
-
V
-
K
E
F
Y
I
G
G
K
I
E
A
V
-
N
K
L
N
--
H
-
Y
-
D
Y
V
A
L
R
Y
T
P
A
E
L
R
V
H
F
D
K
L
G
W
S
R
V
V
A
F
Q
T
R
N
P
M
H
R
A
H
R
E
L
T
V
R
A
A
R
S
R
--
Q
--
A
N
-
V
L
I
H
P
V
V
G
L
T
K
P
G
D
I
D
H
F
T
R
V
R
A
Y
Q
A
L
L
P
R
Y
-
P
N
G
M
A
V
L
G
L
L
G
L
A
M
R
M
G
G
P
R
E
A
I
W
H
A
I
I
R
K
N
H
G
A
T
H
F
I
V
G
R
D
H
A
G
P
G
------
S
NSKGED
F
Y
G
P
Y
D
A
Q
H
A
V
-
E
K
Y
--
K
D
E
L
G
I
E
V
V
E
F
Q
M
V
T
Y
L
P
D
T
D
E
Y
R
P
V
D
Q
V
P
-
A
G
V
-
K
T
--
L
N
I
S
G
T
E
L
R
R
-
R
L
R
S
G
A
H
I
P
E
W
F
S
Y
P
E
V
V
K
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
86.16
39%
-129
- C4 -
4DNX
1
SAT_ALLVD
B:
[46-388]
----------------------------------------------------------------------------
M
L
G
A
G
Y
F
S
P
L
D
G
F
M
N
L
A
D
A
L
S
S
A
Q
S
M
T
L
T
D
G
R
F
F
P
V
P
L
L
C
L
L
--
E
S
--
A
--
D
A
--
I
A
G
A
T
R
I
A
L
RDPN
V
--
E
---
G
N
-
P
-
V
L
A
V
M
D
V
T
A
V
E
Q
V
---
S
D
A
Q
M
A
L
MTE
Q
V
Y
G
T
S
D
P
K
H
P
G
V
E
T
F
N
-
S
-
Q
-
G
R
T
A
I
S
G
P
I
-
Q
V
-
L
N
F
S
YF
Q
-
T
-
D
F
P
D
T
F
R
T
A
V
E
I
R
H
E
I
Q
E
R
G
W
Q
K
I
V
A
F
Q
T
R
N
P
M
H
R
A
H
-
E
E
L
C
K
M
A
M
E
A
--
V
EA
D
G
-
V
V
I
H
M
L
L
G
Q
L
K
P
G
D
I
P
A
P
V
R
D
A
A
I
R
T
M
A
E
L
Y
F
P
P
N
T
V
M
V
T
G
Y
G
F
D
M
L
Y
A
G
P
R
E
A
V
L
H
A
Y
F
R
Q
N
M
G
A
T
H
F
I
I
G
R
D
H
A
G
V
G
------
D
------
Y
Y
G
P
F
D
A
Q
T
I
F
D
D
A
V
P
-
T
D
V
L
A
I
E
I
F
R
A
D
N
T
A
Y
S
K
K
L
G
R
V
V
M
M
R
D
A
P
D
H
T
P
-
D
D
-
F
I
Q
L
S
G
T
R
V
R
E
-
M
L
G
Q
G
E
A
P
P
P
E
F
S
R
P
E
V
A
Q
I
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
86.05
39%
-92
- C4 -
1G8F
24
MET3_YEAST
A:
[2-511]
---
P
A
P
H
G
G
I
-
L
Q
D
L
-
I
--
A
R
D
A
L
-
K
----------
K
N
E
L
L
S
E
A
Q
SSD
I
L
V
W
N
------
L
T
P
R
Q
-------
L
C
D
I
E
L
I
L
N
G
G
F
S
P
L
T
G
F
L
N
E
N
D
Y
S
S
V
V
T
D
S
R
L
A
D
G
T
L
W
T
I
P
I
T
L
D
V
D
E
A
F
--
A
--
N
Q
--
I
K
P
D
T
R
I
A
L
----
F
Q
-
D
---
D
E
-
I
-
P
I
A
I
L
T
V
Q
D
V
Y
K
P
---
N
K
T
I
E
A
E
---
R
V
F
R
G
-
D
P
E
H
P
A
I
S
Y
L
F
-
N
-
V
A
G
D
Y
Y
V
G
G
S
L
-
E
A
I
Q
L
P
Q
--
H
-
Y
-
D
Y
P
G
L
R
K
T
P
A
Q
L
R
L
E
F
Q
S
R
Q
W
D
R
V
V
A
F
Q
T
R
N
P
M
H
R
A
H
-
R
E
L
T
V
R
A
A
R
E
--
A
N-
A
K
-
V
L
I
H
P
V
V
G
L
T
K
P
G
D
I
D
H
H
T
R
V
R
V
Y
Q
E
I
I
K
R
Y
-
P
N
G
I
A
F
L
S
L
L
P
L
A
M
R
M
S
G
D
R
E
A
V
W
H
A
I
I
R
K
N
Y
G
A
S
H
F
I
V
G
R
D
H
A
G
P
G
------
K
NSKGVD
F
Y
G
P
Y
D
A
Q
E
L
V
-
E
S
Y
--
K
H
E
L
D
I
E
V
V
P
F
R
M
V
T
Y
L
P
D
E
D
R
Y
A
P
I
D
Q
I
D
-
T
T
K
-
T
R
-
T
L
N
I
S
G
T
E
L
R
R
-
R
L
R
V
G
G
E
I
P
E
W
F
S
Y
P
E
V
V
K
I
L
R
E
S
N
P
P
R
P
K
Q
G
F
S
I
----
V
LGNS
L
T
V
S
R
E
Q
L
S
I
A
L
L
S
T
F
L
Q
FGGG
R
Y
Y
K
IFEHNNK
T
E
L
L
S
L
I
Q
D
F
I
G
S
G
S
G
L
I
I
PDQWEDDKDSVVGKQN
V
Y
L
L
D
TSSSADIQLESADEP
I
S
H
I
V
Q
K
V
V
L
F
L
E
D
N
GFFVF-------------------------------------------------------------
13
PsiBlast_PDB
85.65
39%
-127
- C4 -
4DNX
1
SAT_ALLVD
A:
[46-388]
----------------------------------------------------------------------------
M
L
G
A
G
Y
F
S
P
L
D
G
F
M
N
L
A
D
A
L
S
S
A
Q
S
M
T
L
T
D
G
R
F
F
P
V
P
L
L
C
L
L
--
E
S
--
A
--
D
A
--
I
A
G
A
T
R
I
A
L
R
D
PN
V
--
E
---
G
N
-
P
-
V
L
A
V
M
D
V
T
A
V
E
Q
V
---
S
D
A
Q
M
A
L
M
T
E
Q
V
Y
G
T
S
D
P
K
H
P
G
V
E
T
F
N
-
S
-
Q
-
G
R
T
A
I
S
G
P
I
-
Q
V
-
L
N
F
S
Y
F
Q
-
T
-
D
F
P
D
T
F
R
T
A
V
E
I
R
H
E
I
Q
E
R
G
W
Q
K
I
V
A
F
Q
T
R
N
P
M
H
R
A
H
-
E
E
L
C
K
M
A
M
E
A
--
V
EA
D
G
-
V
V
I
H
M
L
L
G
Q
L
K
P
G
D
I
P
A
P
V
R
D
A
A
I
R
T
M
A
E
L
Y
F
P
P
N
T
V
M
V
T
G
Y
G
F
D
M
L
Y
A
G
P
R
E
A
V
L
H
A
Y
F
R
Q
N
M
G
A
T
H
F
I
I
G
R
D
H
A
G
V
G
------
D
------
Y
Y
G
P
F
D
A
Q
T
I
F
D
D
A
V
P
-
T
D
V
L
A
I
E
I
F
R
A
D
N
T
A
Y
S
K
K
L
G
R
V
V
M
M
R
D
A
P
D
H
T
P
-
D
D
-
F
I
Q
L
S
G
T
R
V
R
E
-
M
L
G
Q
G
E
A
P
P
P
E
F
S
R
P
E
V
A
Q
I
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
85.42
40%
-93
- C4 -
1R6X
4
MET3_YEAST
A:
[3-383]
-----
P
H
G
G
I
-
L
Q
D
L
-
I
A
R
D
A
L
K
K
-
N
----------
E
L
L
S
E
A
Q
---------
S
------
S
D
I
L
V
W
N
L
T
P
R
Q
L
C
D
I
E
L
I
L
N
G
G
F
S
P
L
T
G
F
L
N
E
N
D
Y
S
S
V
V
T
D
S
R
L
A
D
G
T
L
W
T
I
P
I
T
L
D
V
D
E
A
F
--
A
--
N
Q
--
I
K
P
D
T
R
I
A
L
----
F
--
Q
---
D
D
E
I
-
P
I
A
I
L
T
V
Q
D
V
Y
K
P
---
N
K
T
I
E
A
E
---
K
V
F
R
-
G
D
P
E
H
P
A
I
S
Y
L
F
N
V
-
A
-
G
D
Y
Y
V
G
G
S
L
-
E
A
-
I
Q
L
P
--
Q
-
H
Y
D
Y
P
G
L
R
K
T
P
A
Q
L
R
L
E
F
Q
S
R
Q
W
D
R
V
V
A
F
Q
T
R
N
P
M
H
R
A
H
R
E
L
T
V
R
A
A
R
E
A
--
N
--
A
K
-
V
L
I
H
P
V
V
G
L
T
K
P
G
D
I
D
H
H
T
R
V
R
V
Y
Q
E
I
I
K
R
-
Y
P
N
G
I
A
F
L
S
L
L
P
L
A
M
R
M
S
G
D
R
E
A
V
W
H
A
I
I
R
K
N
Y
G
A
S
H
F
I
V
G
R
D
H
A
G
P
G
KNSKGV
D
------
F
Y
G
P
Y
D
A
Q
E
L
V
-
E
S
Y
--
K
H
E
L
D
I
E
V
V
P
F
R
M
V
T
Y
L
P
D
E
D
R
Y
A
P
I
D
Q
I
D
-
T
T
K
-
T
R
-
T
L
N
I
S
G
T
E
L
R
R
-
R
L
R
V
G
G
E
I
P
E
W
F
S
Y
P
E
V
V
K
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
85.41
40%
-97
- C4 -
1JEC
22
MET3_YEAST
A:
[3-383]
-----
P
H
G
G
I
-
L
Q
D
L
-
I
A
R
D
A
L
K
K
-
N
----------
E
L
L
S
E
A
Q
---------
S
------
S
D
I
L
V
W
N
L
T
P
R
Q
L
C
D
I
E
L
I
L
N
G
G
F
S
P
L
T
G
F
L
N
E
N
D
Y
S
S
V
V
T
D
S
R
L
A
D
G
T
L
W
T
I
P
I
T
L
D
V
D
E
A
F
--
A
--
N
Q
--
I
K
P
D
T
R
I
A
L
----
F
--
Q
---
D
D
E
I
-
P
I
A
I
L
T
V
Q
D
V
Y
K
P
---
N
K
T
I
E
A
E
---
K
V
F
R
-
G
D
P
E
H
P
A
I
S
Y
L
F
N
V
-
A
-
G
D
Y
Y
V
G
G
S
L
-
E
A
-
I
Q
L
P
--
Q
-
H
Y
D
Y
P
G
L
R
K
T
P
A
Q
L
R
L
E
F
Q
S
R
Q
W
D
R
V
V
A
F
Q
T
R
N
P
M
H
R
A
H
R
E
L
T
V
R
A
A
R
E
A
--
N
--
A
K
-
V
L
I
H
P
V
V
G
L
T
K
P
G
D
I
D
H
H
T
R
V
R
V
Y
Q
E
I
I
K
R
-
Y
P
N
G
I
A
F
L
S
L
L
P
L
A
M
R
M
S
G
D
R
E
A
V
W
H
A
I
I
R
K
N
Y
G
A
S
H
F
I
V
G
R
D
H
A
G
P
G
KNSKGV
D
------
F
Y
G
P
Y
D
A
Q
E
L
V
-
E
S
Y
--
K
H
E
L
D
I
E
V
V
P
F
R
M
V
T
Y
L
P
D
E
D
R
Y
A
P
I
D
Q
I
D
-
T
T
K
-
T
R
-
T
L
N
I
S
G
T
E
L
R
R
-
R
L
R
V
G
G
E
I
P
E
W
F
S
Y
P
E
V
V
K
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
85.08
40%
-93
- C4 -
1JED
15
MET3_YEAST
B:
[3-383]
-----
P
H
G
G
I
-
L
Q
D
L
-
I
AR
D
A
L
K
K
-
N
----------
E
L
L
S
E
A
Q
---------
S
------
S
D
I
L
V
WNLTPRQ
L
C
D
I
E
L
I
L
N
G
G
F
S
P
L
T
G
F
L
N
E
N
D
Y
S
S
V
V
T
D
S
R
L
A
D
G
T
L
W
T
I
P
I
T
L
D
V
D
E
A
F
--
A
--
N
Q
--
I
K
P
D
T
R
I
A
L
----
F
--
Q
---
D
D
E
I
-
P
I
A
I
L
T
V
Q
D
V
Y
K
P
---
N
K
T
I
E
A
E
---
K
V
F
R
-
G
D
P
E
H
P
A
I
S
Y
L
F
N
V
-
A
-
G
D
Y
Y
V
G
G
S
L
-
E
A
-
I
Q
L
P
--
Q
-
H
Y
D
Y
P
G
L
R
K
T
P
A
Q
L
R
L
E
F
Q
S
R
Q
W
D
R
V
V
A
F
Q
T
R
N
P
M
H
R
A
H
R
E
L
T
V
R
A
A
R
E
A
--
N
--
A
K
-
V
L
I
H
P
V
V
G
L
T
K
P
G
D
I
D
H
H
T
R
V
R
V
Y
Q
E
I
I
K
R
-
Y
P
N
G
I
A
F
L
S
L
L
P
L
A
M
R
M
S
G
D
R
E
A
V
W
H
A
I
I
R
K
N
Y
G
A
S
H
F
I
V
G
R
D
H
A
G
P
G
KNSKGV
D
------
F
Y
G
P
Y
D
A
Q
E
L
V
-
E
S
Y
--
K
H
E
L
D
I
E
V
V
P
F
R
M
V
T
Y
L
P
D
E
D
R
Y
A
P
I
D
Q
I
D
-
T
T
K
-
T
R
-
T
L
N
I
S
G
T
E
L
R
R
-
R
L
R
V
G
G
E
I
P
E
W
F
S
Y
P
E
V
V
K
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.66
41%
-107
- C4 -
2GKS
1
SATC_AQUAE
B:
[11-361]
----------------------------------------------------
Q
------
I
S
Q
R
S
-------
V
L
D
L
E
L
L
A
V
G
A
F
T
P
L
D
R
F
M
G
E
E
D
Y
R
N
V
V
E
S
M
R
L
K
S
G
T
L
F
P
I
P
I
T
L
P
M
E
K
E
I
--
A
--
K
D
--
L
K
E
G
E
W
I
V
L
----
R
--
D
P--
K
N
-
V
-
P
L
A
I
M
R
V
E
E
V
Y
K
W
---
N
L
E
Y
E
A
K
---
N
V
L
G
T
T
D
P
R
H
P
L
V
A
E
M
H
-
T
-
W
-
G
E
Y
Y
I
S
G
E
L
-
K
V
-
I
Q
L
P
--
K
-
Y
Y
D
F
P
E
Y
R
K
T
P
K
Q
V
R
E
E
I
K
S
L
G
L
D
K
I
V
A
F
Q
T
R
N
P
M
H
R
V
H
-
E
E
L
T
K
R
A
M
E
K
--
V
--
G
G
G
L
L
L
H
P
V
V
G
L
T
K
P
G
D
V
D
V
Y
T
R
M
R
I
Y
K
V
L
Y
E
K
Y
Y
D
K
K
K
T
I
L
A
F
L
P
L
A
M
R
M
A
G
P
R
E
A
L
W
H
G
I
I
R
R
N
Y
G
A
T
H
F
I
V
G
R
D
H
A
S
P
G
------
K
DSKGKP
F
Y
D
P
Y
E
A
Q
E
L
F
-
K
K
Y
--
E
D
E
I
G
I
K
M
V
P
F
E
E
L
V
Y
V
P
E
L
D
Q
Y
V
E
I
N
------------------
E
I
R
E
N
F
L
K
Q
G
R
K
L
P
E
W
F
T
R
P
E
V
A
E
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.41
42%
-101
- C4 -
1V47
9
?
A:
[17-349]
-------------------------------------------------------------------------
D
L
E
N
L
A
T
G
A
F
F
P
V
K
G
F
M
T
R
E
E
A
L
S
V
A
H
E
M
R
L
P
T
G
E
V
W
T
I
P
I
L
L
Q
F
R
E
K
P
------
R
--
V
G
P
G
N
T
V
A
L
----
L
--
H
---
G
G
-
E
-
R
V
A
L
L
H
V
A
E
A
Y
E
L
---
D
L
E
A
L
A
R
---
A
V
F
G
T
D
S
E
T
H
P
G
V
A
R
L
Y
-
G
-
K
-
G
P
Y
A
L
A
G
R
V
-
E
V
L
K
P
R
P
--
R
-
T
-
P
L
E
K
---
T
P
E
E
V
R
A
F
F
R
Q
R
G
W
R
K
V
V
A
F
Q
T
R
N
A
P
H
R
A
H
-
E
Y
L
I
R
L
G
L
E
L
--
A
--
D
G
-
V
L
V
H
P
I
L
G
A
K
K
P
D
D
F
P
T
E
V
I
V
E
A
Y
Q
A
L
I
R
D
F
L
P
Q
E
R
V
A
F
F
G
L
A
T
P
M
R
Y
A
G
P
K
E
A
V
F
H
A
L
V
R
K
N
F
G
A
T
H
F
L
V
G
R
D
H
A
G
V
G
------
D
------
F
Y
D
P
Y
A
A
H
R
I
F
-
D
R
L
P
---
P
L
G
I
E
I
V
K
V
G
A
V
F
H
C
P
L
C
G
G
I
A
S
E
R
T
C
P
-
E
G
H
-
R
E
K
R
T
A
I
S
M
T
K
V
R
A
-
L
L
R
E
G
K
A
P
P
S
E
L
V
R
P
E
L
L
P
I
L
R
R
---
G
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.18
41%
-105
- C4 -
2GKS
1
SATC_AQUAE
A:
[11-367]
----------------------------------------------------
Q
------
I
S
Q
R
S
-------
V
L
D
L
E
L
L
A
V
G
A
F
T
P
L
D
R
F
M
G
E
E
D
Y
R
N
V
V
E
S
M
R
L
K
S
G
T
L
F
P
I
P
I
T
L
P
M
E
K
E
I
--
A
--
K
D
--
L
K
E
G
E
W
I
V
L
----
R
--
D
P--
K
N
-
V
-
P
L
A
I
M
R
V
E
E
V
Y
K
W
---
N
L
E
Y
E
A
K
---
N
V
L
G
T
T
D
P
R
H
P
L
V
A
E
M
H
-
T
-
W
-
G
E
Y
Y
I
S
G
E
L
-
K
V
-
I
Q
L
P
--
K
-
Y
Y
D
F
P
E
Y
R
K
T
P
K
Q
V
R
E
E
I
K
S
L
G
L
D
K
I
V
A
F
Q
T
R
N
P
M
H
R
V
H
-
E
E
L
T
K
R
A
M
E
K
--
V
--
G
G
G
L
L
L
H
P
V
V
G
L
T
K
P
G
D
V
D
V
Y
T
R
M
R
I
Y
K
V
L
Y
E
K
Y
Y
D
K
K
K
T
I
L
A
F
L
P
L
A
M
R
M
A
G
P
R
E
A
L
W
H
G
I
I
R
R
N
Y
G
A
T
H
F
I
V
G
R
D
H
A
S
P
G
------
K
DSKGKP
F
Y
D
P
Y
E
A
Q
E
L
F
-
K
K
Y
--
E
D
E
I
G
I
K
M
V
P
F
E
E
L
V
Y
V
P
E
L
D
Q
Y
V
E
I
N
------------------
E
I
R
E
N
F
L
K
Q
G
R
K
L
P
E
W
F
T
R
P
E
V
A
E
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
83.62
42%
-100
- C4 -
1V47
3
?
B:
[17-347]
-------------------------------------------------------------------------
D
L
E
N
L
A
T
G
A
F
F
P
V
K
G
F
M
T
R
E
E
A
L
S
V
A
H
E
M
R
L
P
T
G
E
V
W
T
I
P
I
L
L
Q
F
R
E
K
P
------
R
--
V
G
P
G
N
T
V
A
L
----
L
--
H
---
G
G
-
E
-
R
V
A
L
L
H
V
A
E
A
Y
E
L
---
D
L
E
A
L
A
R
---
A
V
F
G
T
D
S
E
T
H
P
G
V
A
R
L
Y
-
G
-
K
-
G
P
Y
A
L
A
G
R
V
-
E
V
L
K
P
R
P
--
R
-
T
-
P
L
E
K
---
T
P
E
E
V
R
A
F
F
R
Q
R
G
W
R
K
V
V
A
F
Q
T
R
N
A
P
H
R
A
H
-
E
Y
L
I
R
L
G
L
E
L
--
A
--
D
G
-
V
L
V
H
P
I
L
G
A
K
K
P
D
D
F
P
T
E
V
I
V
E
A
Y
Q
A
L
I
R
D
F
L
P
Q
E
R
V
A
F
F
G
L
A
T
P
M
R
Y
A
G
P
K
E
A
V
F
H
A
L
V
R
K
N
F
G
A
T
H
F
L
V
G
R
D
H
A
G
V
G
------
D
------
F
Y
D
P
Y
A
A
H
R
I
F
-
D
R
L
P
---
P
L
G
I
E
I
V
K
V
G
A
V
F
H
C
P
L
C
G
G
I
A
S
E
R
T
C
P
-
E
G
H
-
R
E
K
R
T
A
I
S
M
T
K
V
R
A
-
L
L
-
E
G
K
A
P
P
S
E
L
V
R
P
E
L
L
P
I
L
R
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------