@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu10970: (2016-06-17 )
MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDGWGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAAKAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIGGTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLPFDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDCLQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDLVSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY
Atome Classification :
(20 SA)
.........10........20........30........40........50-------------.--..-------......60...-----...---..70........80----------.------------.....-----------------.-------------.90........100.......110.......120........130..--.....140....-...150.......160-..-.....170.......180.......190.......200......-.210.......220........--230.--......240.......250.......260.......270.......280.......290-.......300----------.......310..-.....320.-.......330...-..--..---.---340.......350.......360..-.....370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
V
R
IE
T
F
P
L
F
H
R
L
EKPYGDANGF
K
R
Y
R
T
C
Y
L
I
R
I
I
TESGI
D
G
W
G
E
C
V
D
--------------
W
--
L
P
-------
A
L
H
V
G
F
T
K
R
I
I
-----
P
F
L
---
L
GKQAG
S
R
L
S
L
V
R
T
----------
I
------------
Q
K
W
H
Q
-----------------
R
-------------
A
A
S
A
V
S
M
A
L
T
E
I
A
A
KAAD
C
S
V
C
E
L
WGG
R
Y
REE-I
P
V
Y
A
SFQSYSD
S
P
--
Q
W
I
S
R
S
V
S
N
V
E
A
-
Q
L
K
K
G
F
E
Q
I
K
V
K
IGGT-
S
F
-
K
E
D
V
R
H
I
N
A
L
Q
HTAGS
S
I
T
M
I
L
DANQSY
D
A
A
A
A
F
K
W
E
R
Y
F
S
EWT-NIGWLEEPLPFDQ-PQ
D
Y
A
M
L
R
--
S
RLS--VPVAGGENMKG
P
A
Q
Y
V
P
L
L
S
Q
R
C
L
D
IIQPD
V
M
HVN
G
I
D
E
F
R
D
C
L
Q
L
A
R
Y
FGVRASAHAY-DG
S
L
S
R
L
Y
A
L
----------
F
A
Q
ACLP
P
W
S
K
M-KNDHIEP-I-
E
W
D
VMENP
F
-
T
D
L-VS--LQ---P---SK
G
M
V
HIPKGKGIG
T
E
I
N
M
E
I
V
N
R
Y-KWDGSAY
26
PsiBlast_CBE
99.21
99%
-117
- C1 -
2GGE
1
YITF_BACSU
C:
[4-374]
V
K
I
V
R
I
E
T
F
P
L
F
H
R
L
E
K
P
Y
G
D
A
N
G
F
K
R
Y
R
T
C
Y
L
I
R
I
I
T
E
S
G
I
D
G
W
G
E
C
V
D
--------------
W
--
L
P
-------
A
L
H
V
G
F
T
K
R
I
I
-----
P
F
L
---
L
G
K
Q
A
G
S
R
L
S
L
V
R
T
----------
I
------------
Q
K
W
H
Q
-----------------
R
-------------
A
A
S
A
V
S
M
A
L
T
E
I
A
A
K
A
A
D
C
S
V
C
E
L
W
G
G
R
Y
R
E
E
-
I
P
V
Y
A
S
F
Q
S
Y
S
D
S
P
--
Q
W
I
S
R
S
V
S
N
V
E
A
-
Q
L
K
K
G
F
E
Q
I
K
V
K
I
G
G
T
-
S
F
-
K
E
D
V
R
H
I
N
A
L
Q
H
T
A
G
S
S
I
T
M
I
L
D
A
N
Q
S
Y
D
A
A
A
A
F
K
W
E
R
Y
F
S
E
W
T
-
N
I
G
W
L
E
E
P
L
P
F
D
Q
-
P
Q
D
Y
A
M
L
R
--
S
R
L
S
--
V
P
V
A
G
G
E
N
M
K
G
P
A
Q
Y
V
P
L
L
S
Q
R
C
L
D
I
I
Q
P
D
V
M
H
V
N
G
I
D
E
F
R
D
C
L
Q
L
A
R
Y
F
G
V
R
A
S
A
H
A
Y
-
D
G
S
L
S
R
L
Y
A
L
----------
F
A
Q
A
C
L
P
P
W
S
K
M
-
K
N
D
H
I
E
P
-
I
-
E
W
D
V
M
E
N
P
F
-
T
D
L
-
V
S
--
L
Q
---
P
---
S
K
G
M
V
H
I
P
K
G
K
G
I
G
T
E
I
N
M
E
I
V
N
R
Y
-
K
W
D
G
S
A
Y
27
PsiBlast_CBE
98.72
99%
-116
- C1 -
2GGE
2
YITF_BACSU
B:
[4-374]
V
K
I
V
R
I
E
T
F
P
L
F
H
R
L
E
K
P
Y
G
D
A
N
G
F
K
R
Y
R
T
C
Y
L
I
R
I
I
T
E
S
G
I
D
G
W
G
E
C
V
D
--------------
W
--
L
P
-------
A
L
H
V
G
F
T
K
R
I
I
-----
P
F
L
---
L
G
K
Q
A
G
S
R
L
S
L
V
R
T
----------
I
------------
Q
K
W
H
Q
-----------------
R
-------------
A
A
S
A
V
S
M
A
L
T
E
I
A
A
K
A
A
D
C
S
V
C
E
L
W
G
G
R
Y
R
E
E
-
I
P
V
Y
A
S
F
Q
S
Y
S
D
S
P
--
Q
W
I
S
R
S
V
S
N
V
E
A
-
Q
L
K
K
G
F
E
Q
I
K
V
K
I
G
G
T
-
S
F
-
K
E
D
V
R
H
I
N
A
L
Q
H
T
A
G
S
S
I
T
M
I
L
D
A
N
Q
S
Y
D
A
A
A
A
F
K
W
E
R
Y
F
S
E
W
T
-
N
I
G
W
L
E
E
P
L
P
F
D
Q
-
P
Q
D
Y
A
M
L
R
--
S
R
L
S
--
V
P
V
A
G
G
E
N
M
K
G
P
A
Q
Y
V
P
L
L
S
Q
R
C
L
D
I
I
Q
P
D
V
M
H
V
N
G
I
D
E
F
R
D
C
L
Q
L
A
R
Y
F
G
V
R
A
S
A
H
A
Y
-
D
G
S
L
S
R
L
Y
A
L
----------
F
A
Q
A
C
L
P
P
W
S
K
M
-
K
N
D
H
I
E
P
-
I
-
E
W
D
V
M
E
N
P
F
-
T
D
L
-
V
S
--
L
Q
---
P
---
S
K
G
M
V
H
I
P
K
G
K
G
I
G
T
E
I
N
M
E
I
V
N
R
Y
-
K
W
D
G
S
A
Y
1
PsiBlast_PDB
98.41
99%
-115
- C1 -
2GDQ
-
YITF_BACSU
A:
[4-374]
V
K
I
V
R
I
E
T
F
P
L
F
H
R
L
E
K
P
Y
G
D
A
N
G
F
K
R
Y
R
T
C
Y
L
I
R
I
I
T
E
S
G
I
D
G
W
G
E
C
V
D
--------------
W
--
L
P
-------
A
L
H
V
G
F
T
K
R
I
I
-----
P
F
L
---
L
G
K
Q
A
G
S
R
L
S
L
V
R
T
----------
I
------------
Q
K
W
H
Q
-----------------
R
-------------
A
A
S
A
V
S
M
A
L
T
E
I
A
A
K
A
A
D
C
S
V
C
E
L
W
G
G
R
Y
R
E
E
-
I
P
V
Y
A
S
F
Q
S
Y
S
D
S
P
--
Q
W
I
S
R
S
V
S
N
V
E
A
-
Q
L
K
K
G
F
E
Q
I
K
V
K
I
G
G
T
-
S
F
-
K
E
D
V
R
H
I
N
A
L
Q
H
T
A
G
S
S
I
T
M
I
L
D
A
N
Q
S
Y
D
A
A
A
A
F
K
W
E
R
Y
F
S
E
W
T
-
N
I
G
W
L
E
E
P
L
P
F
D
Q
-
P
Q
D
Y
A
M
L
R
--
S
R
L
S
--
V
P
V
A
G
G
E
N
M
K
G
P
A
Q
Y
V
P
L
L
S
Q
R
C
L
D
I
I
Q
P
D
V
M
H
V
N
G
I
D
E
F
R
D
C
L
Q
L
A
R
Y
F
G
V
R
A
S
A
H
A
Y
-
D
G
S
L
S
R
L
Y
A
L
----------
F
A
Q
A
C
L
P
P
W
S
K
M
-
K
N
D
H
I
E
P
-
I
-
E
W
D
V
M
E
N
P
F
-
T
D
L
-
V
S
--
L
Q
---
P
---
S
K
G
M
V
H
I
P
K
G
K
G
I
G
T
E
I
N
M
E
I
V
N
R
Y
-
K
W
D
G
S
A
Y
2
PsiBlast_PDB
98.30
99%
-116
- C1 -
2GGE
1
YITF_BACSU
A:
[4-374]
V
K
I
V
R
I
E
T
F
P
L
F
H
R
L
E
K
P
Y
G
D
A
N
G
F
K
R
Y
R
T
C
Y
L
I
R
I
I
T
E
S
G
I
D
G
W
G
E
C
V
D
--------------
W
--
L
P
-------
A
L
H
V
G
F
T
K
R
I
I
-----
P
F
L
---
L
G
K
Q
A
G
S
R
L
S
L
V
R
T
----------
I
------------
Q
K
W
H
Q
-----------------
R
-------------
A
A
S
A
V
S
M
A
L
T
E
I
A
A
K
A
A
D
C
S
V
C
E
L
W
G
G
R
Y
R
E
E
-
I
P
V
Y
A
S
F
Q
S
Y
S
D
S
P
--
Q
W
I
S
R
S
V
S
N
V
E
A
-
Q
L
K
K
G
F
E
Q
I
K
V
K
I
G
G
T
-
S
F
-
K
E
D
V
R
H
I
N
A
L
Q
H
T
A
G
S
S
I
T
M
I
L
D
A
N
Q
S
Y
D
A
A
A
A
F
K
W
E
R
Y
F
S
E
W
T
-
N
I
G
W
L
E
E
P
L
P
F
D
Q
-
P
Q
D
Y
A
M
L
R
--
S
R
L
S
--
V
P
V
A
G
G
E
N
M
K
G
P
A
Q
Y
V
P
L
L
S
Q
R
C
L
D
I
I
Q
P
D
V
M
H
V
N
G
I
D
E
F
R
D
C
L
Q
L
A
R
Y
F
G
V
R
A
S
A
H
A
Y
-
D
G
S
L
S
R
L
Y
A
L
----------
F
A
Q
A
C
L
P
P
W
S
K
M
-
K
N
D
H
I
E
P
-
I
-
E
W
D
V
M
E
N
P
F
-
T
D
L
-
V
S
--
L
Q
---
P
---
S
K
G
M
V
H
I
P
K
G
K
G
I
G
T
E
I
N
M
E
I
V
N
R
Y
-
K
W
D
G
S
A
Y
21
PsiBlast_CBE
97.91
99%
-116
- C1 -
2GGE
1
YITF_BACSU
H:
[4-374]
V
K
I
V
R
I
E
T
F
P
L
F
H
R
L
E
K
P
Y
G
D
A
N
G
F
K
R
Y
R
T
C
Y
L
I
R
I
I
T
E
S
G
I
D
G
W
G
E
C
V
D
--------------
W
--
L
P
-------
A
L
H
V
G
F
T
K
R
I
I
-----
P
F
L
---
L
G
K
Q
A
G
S
R
L
S
L
V
R
T
----------
I
------------
Q
K
W
H
Q
-----------------
R
-------------
A
A
S
A
V
S
M
A
L
T
E
I
A
A
K
A
A
D
C
S
V
C
E
L
W
G
G
R
Y
R
E
E
-
I
P
V
Y
A
S
F
Q
S
Y
S
D
S
P
--
Q
W
I
S
R
S
V
S
N
V
E
A
-
Q
L
K
K
G
F
E
Q
I
K
V
K
I
G
G
T
-
S
F
-
K
E
D
V
R
H
I
N
A
L
Q
H
T
A
G
S
S
I
T
M
I
L
D
A
N
Q
S
Y
D
A
A
A
A
F
K
W
E
R
Y
F
S
E
W
T
-
N
I
G
W
L
E
E
P
L
P
F
D
Q
-
P
Q
D
Y
A
M
L
R
--
S
R
L
S
--
V
P
V
A
G
G
E
N
M
K
G
P
A
Q
Y
V
P
L
L
S
Q
R
C
L
D
I
I
Q
P
D
V
M
H
V
N
G
I
D
E
F
R
D
C
L
Q
L
A
R
Y
F
G
V
R
A
S
A
H
A
Y
-
D
G
S
L
S
R
L
Y
A
L
----------
F
A
Q
A
C
L
P
P
W
S
K
M
-
K
N
D
H
I
E
P
-
I
-
E
W
D
V
M
E
N
P
F
-
T
D
L
-
V
S
--
L
Q
---
P
---
S
K
G
M
V
H
I
P
K
G
K
G
I
G
T
E
I
N
M
E
I
V
N
R
Y
-
K
W
D
G
S
A
Y
24
PsiBlast_CBE
97.09
99%
-116
- C1 -
2GGE
1
YITF_BACSU
E:
[4-374]
V
K
I
V
R
I
E
T
F
P
L
F
H
R
L
E
K
P
Y
G
D
A
N
G
F
K
R
Y
R
T
C
Y
L
I
R
I
I
T
E
S
G
I
D
G
W
G
E
C
V
D
--------------
W
--
L
P
-------
A
L
H
V
G
F
T
K
R
I
I
-----
P
F
L
---
L
G
K
Q
A
G
S
R
L
S
L
V
R
T
----------
I
------------
Q
K
W
H
Q
-----------------
R
-------------
A
A
S
A
V
S
M
A
L
T
E
I
A
A
K
A
A
D
C
S
V
C
E
L
W
G
G
R
Y
R
E
E
-
I
P
V
Y
A
S
F
Q
S
Y
S
D
S
P
--
Q
W
I
S
R
S
V
S
N
V
E
A
-
Q
L
K
K
G
F
E
Q
I
K
V
K
I
G
G
T
-
S
F
-
K
E
D
V
R
H
I
N
A
L
Q
H
T
A
G
S
S
I
T
M
I
L
D
A
N
Q
S
Y
D
A
A
A
A
F
K
W
E
R
Y
F
S
E
W
T
-
N
I
G
W
L
E
E
P
L
P
F
D
Q
-
P
Q
D
Y
A
M
L
R
--
S
R
L
S
--
V
P
V
A
G
G
E
N
M
K
G
P
A
Q
Y
V
P
L
L
S
Q
R
C
L
D
I
I
Q
P
D
V
M
H
V
N
G
I
D
E
F
R
D
C
L
Q
L
A
R
Y
F
G
V
R
A
S
A
H
A
Y
-
D
G
S
L
S
R
L
Y
A
L
----------
F
A
Q
A
C
L
P
P
W
S
K
M
-
K
N
D
H
I
E
P
-
I
-
E
W
D
V
M
E
N
P
F
-
T
D
L
-
V
S
--
L
Q
---
P
---
S
K
G
M
V
H
I
P
K
G
K
G
I
G
T
E
I
N
M
E
I
V
N
R
Y
-
K
W
D
G
S
A
Y
25
PsiBlast_CBE
96.93
99%
-116
- C1 -
2GGE
3
YITF_BACSU
D:
[4-374]
V
K
I
V
R
I
E
T
F
P
L
F
H
R
L
E
K
P
Y
G
D
A
N
G
F
K
R
Y
R
T
C
Y
L
I
R
I
I
T
E
S
G
I
D
G
W
G
E
C
V
D
--------------
W
--
L
P
-------
A
L
H
V
G
F
T
K
R
I
I
-----
P
F
L
---
L
G
K
Q
A
G
S
R
L
S
L
V
R
T
----------
I
------------
Q
K
W
H
Q
-----------------
R
-------------
A
A
S
A
V
S
M
A
L
T
E
I
A
A
K
A
A
D
C
S
V
C
E
L
W
G
G
R
Y
R
E
E
-
I
P
V
Y
A
S
F
Q
S
Y
S
D
S
P
--
Q
W
I
S
R
S
V
S
N
V
E
A
-
Q
L
K
K
G
F
E
Q
I
K
V
K
I
G
G
T
-
S
F
-
K
E
D
V
R
H
I
N
A
L
Q
H
T
A
G
S
S
I
T
M
I
L
D
A
N
Q
S
Y
D
A
A
A
A
F
K
W
E
R
Y
F
S
E
W
T
-
N
I
G
W
L
E
E
P
L
P
F
D
Q
-
P
Q
D
Y
A
M
L
R
--
S
R
L
S
--
V
P
V
A
G
G
E
N
M
K
G
P
A
Q
Y
V
P
L
L
S
Q
R
C
L
D
I
I
Q
P
D
V
M
H
V
N
G
I
D
E
F
R
D
C
L
Q
L
A
R
Y
F
G
V
R
A
S
A
H
A
Y
-
D
G
S
L
S
R
L
Y
A
L
----------
F
A
Q
A
C
L
P
P
W
S
K
M
-
K
N
D
H
I
E
P
-
I
-
E
W
D
V
M
E
N
P
F
-
T
D
L
-
V
S
--
L
Q
---
P
---
S
K
G
M
V
H
I
P
K
G
K
G
I
G
T
E
I
N
M
E
I
V
N
R
Y
-
K
W
D
G
S
A
Y
22
PsiBlast_CBE
95.23
99%
-109
- C1 -
2GGE
2
YITF_BACSU
G:
[4-374]
V
K
I
V
R
I
E
T
F
P
L
F
H
R
L
E
K
P
Y
G
D
A
N
G
F
K
R
Y
R
T
C
Y
L
I
R
I
I
T
E
S
G
I
D
G
W
G
E
C
V
D
--------------
W
--
L
P
-------
A
L
H
V
G
F
T
K
R
I
I
-----
P
F
L
---
L
G
K
Q
A
G
S
R
L
S
L
V
R
T
----------
I
------------
Q
K
W
H
Q
-----------------
R
-------------
A
A
S
A
V
S
M
A
L
T
E
I
A
A
K
A
A
D
C
S
V
C
E
L
W
G
G
R
Y
R
E
E
-
I
P
V
Y
A
S
F
Q
S
Y
S
D
S
P
--
Q
W
I
S
R
S
V
S
N
V
E
A
-
Q
L
K
K
G
F
E
Q
I
K
V
K
I
G
G
T
-
S
F
-
K
E
D
V
R
H
I
N
A
L
Q
H
T
A
G
S
S
I
T
M
I
L
D
A
N
Q
S
Y
D
A
A
A
A
F
K
W
E
R
Y
F
S
E
W
T
-
N
I
G
W
L
E
E
P
L
P
F
D
Q
-
P
Q
D
Y
A
M
L
R
--
S
R
L
S
--
V
P
V
A
G
G
E
N
M
K
G
P
A
Q
Y
V
P
L
L
S
Q
R
C
L
D
I
I
Q
P
D
V
M
H
V
N
G
I
D
E
F
R
D
C
L
Q
L
A
R
Y
F
G
V
R
A
S
A
H
A
Y
-
D
G
S
L
S
R
L
Y
A
L
----------
F
A
Q
A
C
L
P
P
W
S
K
M
-
K
N
D
H
I
E
P
-
I
-
E
W
D
V
M
E
N
P
F
-
T
D
L
-
V
S
--
L
Q
---
P
---
S
K
G
M
V
H
I
P
K
G
K
G
I
G
T
E
I
N
M
E
I
V
N
R
Y
-
K
W
D
G
S
A
Y
23
PsiBlast_CBE
94.79
99%
-114
- C1 -
2GGE
1
YITF_BACSU
F:
[4-374]
V
K
I
V
R
I
E
T
F
P
L
F
H
R
L
E
K
P
Y
G
D
A
N
G
F
K
R
Y
R
T
C
Y
L
I
R
I
I
T
E
S
G
I
D
G
W
G
E
C
V
D
--------------
W
--
L
P
-------
A
L
H
V
G
F
T
K
R
I
I
-----
P
F
L
---
L
G
K
Q
A
G
S
R
L
S
L
V
R
T
----------
I
------------
Q
K
W
H
Q
-----------------
R
-------------
A
A
S
A
V
S
M
A
L
T
E
I
A
A
K
A
A
D
C
S
V
C
E
L
W
G
G
R
Y
R
E
E
-
I
P
V
Y
A
S
F
Q
S
Y
S
D
S
P
--
Q
W
I
S
R
S
V
S
N
V
E
A
-
Q
L
K
K
G
F
E
Q
I
K
V
K
I
G
G
T
-
S
F
-
K
E
D
V
R
H
I
N
A
L
Q
H
T
A
G
S
S
I
T
M
I
L
D
A
N
Q
S
Y
D
A
A
A
A
F
K
W
E
R
Y
F
S
E
W
T
-
N
I
G
W
L
E
E
P
L
P
F
D
Q
-
P
Q
D
Y
A
M
L
R
--
S
R
L
S
--
V
P
V
A
G
G
E
N
M
K
G
P
A
Q
Y
V
P
L
L
S
Q
R
C
L
D
I
I
Q
P
D
V
M
H
V
N
G
I
D
E
F
R
D
C
L
Q
L
A
R
Y
F
G
V
R
A
S
A
H
A
Y
-
D
G
S
L
S
R
L
Y
A
L
----------
F
A
Q
A
C
L
P
P
W
S
K
M
-
K
N
D
H
I
E
P
-
I
-
E
W
D
V
M
E
N
P
F
-
T
D
L
-
V
S
--
L
Q
---
P
---
S
K
G
M
V
H
I
P
K
G
K
G
I
G
T
E
I
N
M
E
I
V
N
R
Y
-
K
W
D
G
S
A
Y
28
HHSearch
89.55
94%
-112
- C1 -
2GDQ
-
YITF_BACSU
A:
[4-374]
V
K
I
V
R
I
E
T
F
P
L
F
H
R
L
E
K
P
Y
G
D
A
N
G
F
K
R
Y
R
T
C
Y
L
I
R
I
I
T
E
S
G
I
D
G
W
G
E
C
V
D
--------------
W
--
L
P
-------
A
L
H
V
G
F
T
K
R
I
I
-----
P
F
L
---
L
G
K
Q
A
G
S
R
L
S
L
V
R
T
----------
I
------------
Q
K
W
H
Q
-----------------
R
-------------
A
A
S
A
V
S
M
A
L
T
E
I
A
A
K
A
A
D
C
S
V
C
E
L
W
G
G
R
Y
R
E
E
-
I
P
V
Y
A
S
F
Q
S
Y
S
D
S
P
Q
W
I
S
R
S
--
V
S
N
V
E
A
-
Q
L
K
K
G
F
E
Q
I
K
V
K
I
G
G
T
--
S
F
K
E
D
V
R
H
I
N
A
L
Q
H
T
A
G
S
S
I
T
M
I
L
D
A
N
Q
S
Y
D
A
A
A
A
F
K
W
E
R
Y
F
S
E
-
W
T
N
I
G
W
L
E
E
P
L
P
F
D
Q
-
P
Q
D
Y
A
M
L
R
--
S
R
L
S
--
V
P
V
A
G
G
E
N
M
K
G
P
A
Q
Y
V
P
L
L
S
Q
R
C
L
D
I
I
Q
P
D
V
M
H
V
N
G
I
D
E
F
R
D
C
L
Q
L
A
R
Y
F
G
V
R
A
S
A
H
A
Y
-
D
G
S
L
S
R
L
Y
A
L
----------
F
A
Q
A
C
L
P
P
-
W
S
K
-
M
K
N
D
H
I
E
P
I
-
E
W
D
V
M
-
E
N
P
-
F
T
D
L
V
S
--
L
Q
---
P
---
S
K
G
M
V
H
I
P
K
G
K
G
I
G
T
E
I
N
M
E
I
V
N
R
Y
-
K
W
D
G
S
A
Y
3
PsiBlast_PDB
54.80
31%
-115
- C1 -
4GGB
8
GCI_AGRFC
A:
[1-374]
M
K
I
T
A
V
R
T
H
L
L
-------------------
H
V
L
V
E
I
E
C
D
D
G
T
V
G
W
G
E
C
L
G
P
A
R
P
N
A
A
V
V
Q
A
Y
S
G
W
--
L
I
-------
G
Q
D
P
R
Q
T
E
K
I
W
-----
A
V
L
Y
N
A
L
R
D
Q
G
Q
R
G
L
S
L
T
-------------------------------------------------------------
A
L
S
G
I
D
I
A
L
W
D
I
K
G
K
H
Y
G
A
S
I
S
M
L
L
G
G
R
W
R
E
S
-
V
R
A
Y
A
T
G
---------
D
R
V
S
D
N
A
S
E
M
A
E
-
R
R
A
E
G
F
H
A
C
K
I
K
I
G
-
F
-
G
V
-
E
E
D
L
R
V
I
A
A
V
R
E
A
I
G
P
D
M
R
L
M
I
D
A
N
H
G
Y
T
V
T
E
A
I
T
L
G
D
R
A
A
G
F
--
G
I
D
W
F
E
E
P
V
V
P
E
Q
-
L
D
A
Y
A
R
V
R
--
A
G
Q
P
--
I
P
V
A
G
G
E
T
W
H
G
R
Y
G
M
W
Q
A
L
S
A
G
A
V
D
I
L
Q
P
D
L
C
G
C
G
G
F
S
E
I
Q
K
I
A
T
L
A
T
L
H
G
V
R
I
V
P
H
V
W
-
G
T
G
V
Q
I
A
A
A
L
----------
Q
F
M
A
A
M
T
P
-
D
P
V
-
R
V
N
P
I
E
P
-
I
M
E
F
D
R
T
H
N
P
F
-
R
Q
A
-
V
L
--
R
E
---
P
LEA
V
N
G
V
V
T
I
P
D
G
P
G
L
G
I
E
I
N
R
D
A
L
T
E
F
-
R
------
4
PsiBlast_PDB
50.71
31%
-94
- C1 -
4HPN
4
GCI_AGRFC
A:
[1-374]
M
K
I
T
A
V
R
T
H
L
L
E
H
R
L
D
T
P
F
E
S
A
S
M
R
F
D
R
R
A
H
V
L
V
E
I
E
C
D
D
G
T
V
G
W
G
E
C
L
G
P
A
R
P
N
A
A
V
V
Q
A
Y
SG
W
--
L
I
-------
G
Q
D
P
R
Q
T
E
K
I
W
-----
A
V
L
Y
N
A
L
R
D
Q
G
Q
R
G
L
S
L
T
-------------------------------------------------------------
A
L
S
G
I
D
I
A
L
W
D
I
K
G
K
H
Y
G
A
S
I
S
M
L
L
G
G
R
W
R
E
S
-
V
R
A
Y
A
T
G
S
F
K
R
D
N
V
--
D
R
V
S
D
N
A
S
E
M
A
E
-
R
R
A
E
G
F
H
A
C
K
I
K
I
G
-
F
-
G
V
-
E
E
D
L
R
V
I
A
A
V
R
E
A
I
G
P
D
M
R
L
M
I
D
A
N
H
G
Y
T
V
T
E
A
I
T
L
G
D
R
A
A
G
F
--
G
I
D
W
F
E
E
P
V
V
P
E
Q
-
L
D
A
Y
A
R
V
R
--
A
G
Q
P
--
I
P
V
A
G
G
E
T
W
H
G
R
Y
G
M
W
Q
A
L
S
A
G
A
V
D
I
L
Q
P
D
L
C
G
C
G
G
F
S
E
I
Q
K
I
A
T
L
A
T
L
H
G
V
R
I
V
P
H
V
W
-
G
T
G
V
Q
I
A
A
A
L
----------
Q
F
M
A
A
M
T
P
-
D
P
V
-
R
V
N
P
I
E
P
-
I
M
E
F
D
R
T
H
N
P
F
-
R
Q
A
-
V
L
--
R
E
---
P
LEA
V
N
G
V
V
T
I
P
D
G
P
G
L
G
I
E
I
N
R
D
A
L
T
E
F
-
R
------
16
PsiBlast_PDB
48.07
24%
-101
- C1 -
3OP2
2
?
A:
[28-377]
-----------------------
G
L
K
L
N
R
Q
M
I
L
V
E
V
R
T
D
E
G
V
T
G
V
G
S
P
S
G
--------------
P
YD
L
A
-------
V
L
K
R
A
I
E
D
V
I
G
-----
P
Q
L
---
I
G
E
D
P
A
N
I
N
Y
L
----------------------------
W
H
K
V
F
H
G
EVSRS
V
G
I
-----
A
-------------
A
M
S
G
V
D
I
A
L
W
D
L
K
G
R
A
M
N
Q
P
I
Y
Q
L
L
G
G
K
F
H
T
R
G
V
R
A
Y
A
S
S
I
Y
W
D
L
T
P
-----
D
Q
A
A
D
E
L
A
G
-
W
V
E
Q
G
F
T
A
A
K
L
K
V
G
-
R
-
A
P
-
R
K
D
A
A
N
L
R
A
M
R
Q
R
V
G
A
D
V
E
I
L
V
D
A
N
Q
S
L
G
R
H
D
A
L
A
M
L
R
I
L
D
E
-
A
-
G
C
Y
W
F
E
E
P
L
S
I
D
D
-
I
E
G
H
R
I
L
R
--
A
Q
G
T
P-
V
R
I
A
T
G
E
N
L
Y
T
R
N
A
F
N
D
Y
I
R
N
D
A
I
D
V
L
Q
A
D
A
S
R
A
G
G
I
T
E
A
L
A
I
S
A
S
A
A
S
A
H
L
A
W
N
P
H
T
F
-
N
D
I
I
T
V
A
A
N
L
----------
H
L
V
A
A
S
P
---------
H
P
A
M
-
F
-
E
W
D
I
T
H
N
D
L
M
T
R
L
-
A
S
YD
L
K
---
L
---
E
N
G
L
V
Q
P
P
Q
G
P
G
L
G
F
E
I
D
W
D
F
V
A
A
H
-
A
W
K
G
---
5
PsiBlast_PDB
47.29
25%
-99
- C1 -
3BJS
1
?
A:
[39-412]
M
K
I
T
K
I
N
A
I
P
L
S
Y
R
L
P
-
T
V
T
M
G
V
G
S
T
I
K
R
D
A
I
I
I
R
V
E
T
S
E
G
I
T
G
Y
G
E
A
-------------------
H
P
-------
G
R
S
P
G
A
I
T
S
L
I
H
N
T
I
A
P
M
L
---
I
G
M
K
A
---
T
D
C
V
G
A
----------
W
------------
Q
R
V
H
R
-----------------
M
QLSSHGLG
A
G
A
A
L
A
I
S
G
I
D
M
A
L
W
D
I
R
G
K
A
A
N
M
P
L
Y
E
L
L
G
G
S
K
R
R
--
I
P
A
Y
A
G
G
I
A
L
G
Y
Q
P
--
K
--
E
S
L
A
E
E
A
Q
E
-
Y
I
A
R
G
Y
K
A
L
K
L
R
I
G
D
A
-
A
--
R
V
D
I
E
R
V
R
H
V
R
K
V
L
G
D
E
V
D
I
L
T
D
A
N
T
A
Y
T
M
A
D
A
R
R
V
L
P
V
L
A
E
-
I
-
Q
A
G
W
L
E
E
P
F
A
C
N
----
D
F
A
S
Y
R
E
V
A
K
I
T
PL
V
P
I
A
A
G
E
N
H
Y
T
R
F
E
F
G
Q
M
L
D
A
G
A
V
Q
V
W
Q
P
D
L
S
K
C
G
G
I
T
E
G
I
R
I
A
A
M
A
S
A
Y
R
I
P
I
N
A
H
S
S
-
A
T
G
L
N
H
A
A
T
I
H
F
L
A
A
TENAG
Y
F
E
A
C
V
S
K
F
--------------------
N
P
F
-
R
D
M
-
F
G
--
T
-FEI
G
---
A
D
G
C
V
E
P
P
D
A
P
G
L
G
I
E
V
D
E
S
I
F
E
K
Y
P
A
V
D
----
33
HHSearch
47.06
19%
-102
- C1 -
2PGW
2
?
A:
[4-372]
V
K
I
S
N
V
R
V
R
P
L
V
L
P
L
K
Q
P
Y
H
W
S
Y
G
I
R
E
S
F
A
V
N
L
I
E
I
E
A
D
D
G
T
V
G
I
G
E
C
T
V
--------------
A
--
P
D
Q
------
T
G
T
A
A
I
L
Y
R
L
A
-----
K
H
L
---
V
G
H
S
P
H
D
V
A
P
L
I
A
R
----------
I
F
H
Q
EYLGHGANI
M
R
A
A
N
-----------------
Q
-------------
I
F
S
G
I
D
M
A
M
W
D
L
Q
G
K
L
A
G
L
P
V
H
Q
L
L
G
G
A
H
R
K
A
-
V
G
Y
F
Y
F
L
Q
-
G
E
T
-
A
---
E
E
L
--
A
R
D
A
A
V
-
G
H
A
Q
G
E
R
V
F
Y
L
K
V
G
R
G
-
E
--
K
L
D
L
E
I
T
A
A
V
R
G
E
I
G
-
D
A
R
L
R
L
D
A
N
E
G
W
S
V
H
D
A
I
N
M
C
R
K
L
E
K
-
Y
-
D
I
E
F
I
E
Q
P
T
V
S
W
S
-
I
P
A
M
A
H
V
R
--
E
K
V
G
--
I
P
I
V
A
D
Q
A
A
F
T
L
Y
D
V
Y
E
I
C
R
Q
R
A
A
D
M
I
C
I
G
P
R
E
I
G
G
I
Q
P
M
M
K
A
A
A
V
A
E
A
A
G
L
K
I
C
I
H
S
S
F
T
T
G
I
T
T
C
A
E
H
----------
H
I
G
L
A
I
P
N
-
L
D
D
-
G
N
Q
I
----
M
-
W
Q
-
L
V
Q
E
D
I
-
V
S
S
-
P
D
--
L
T
---
P
---
K
N
G
W
L
D
A
F
R
K
P
G
L
G
F
Q
L
A
E
D
L
V
A
E
G
-
E
G
R
Y
---
13
PsiBlast_PDB
46.96
24%
-97
- C1 -
3OZY
8
?
A:
[28-377]
-----------------------
G
L
K
L
N
R
Q
M
I
L
V
E
V
R
T
D
E
G
V
T
G
V
G
S
P
S
G
--------------
P
YD
L
A
-------
V
L
K
R
A
I
E
D
V
I
G
-----
P
Q
L
---
I
G
E
D
P
A
N
I
N
Y
L
----------------------------
W
H
K
V
F
H
G
EVSRNLGHRS
V
G
I
A
-------------
A
M
S
G
V
D
I
A
L
W
D
L
K
G
R
A
M
N
Q
P
I
Y
Q
L
L
G
G
K
F
H
T
R
G
V
R
A
Y
A
S
S
I
Y
W
D
L
T
P
-----
D
Q
A
A
D
E
L
A
G
-
W
V
E
Q
G
F
T
A
A
K
L
K
V
G
-
R
-
A
P
-
R
K
D
A
A
N
L
R
A
M
R
Q
R
V
G
A
D
V
E
I
L
V
D
A
N
Q
S
L
G
R
H
D
A
L
A
M
L
R
I
L
D
E
-
A
-
G
C
Y
W
F
E
E
P
L
S
I
D
D
-
I
E
G
H
R
I
L
R
--
A
Q
G
T
P-
V
R
I
A
T
G
E
N
L
Y
T
R
N
A
F
N
D
Y
I
R
N
D
A
I
D
V
L
Q
A
D
A
S
R
A
G
G
I
T
E
A
L
A
I
S
A
S
A
A
S
A
H
L
A
W
N
P
H
T
F
-
N
D
I
I
T
V
A
A
N
L
----------
H
L
V
A
A
S
P
---------
H
P
A
M
-
F
-
E
W
D
I
T
H
N
D
L
M
T
R
L
-
A
S
Y
D
L
K
---
L
---
E
N
G
L
V
Q
P
P
Q
G
P
G
L
G
F
E
I
D
W
D
F
V
A
A
H
-
A
W
K
G
---
30
HHSearch
46.09
21%
-102
* C1 *
2CHR
2
TFDD1_CUPPJ
A:
[1-368]
M
K
I
D
A
I
E
A
V
I
V
D
V
P
T
K
R
P
I
Q
M
S
I
T
T
V
H
Q
Q
S
Y
V
I
V
R
V
Y
-
S
E
G
L
V
G
V
G
E
G
G
S
--------------
V
GG
P
V
WSAEC
A
E
T
I
K
I
I
V
E
R
Y
L
A
-----
P
H
L
---
L
G
T
D
A
F
N
V
S
G
A
L
Q
T
----------
M
A
R
A
---------
V
T
G
N
A
-----------------
S
-------------
A
K
A
A
V
E
M
A
L
L
D
L
K
A
R
A
L
G
V
S
I
A
E
L
L
G
G
P
L
R
S
A
-
I
P
I
A
W
T
L
A
-
S
G
D
T
----
K
R
D
--
L
D
S
A
V
E
M
I
E
R
R
R
H
N
R
F
K
V
K
L
G
F
R
--
S
P
Q
D
D
L
I
H
M
E
A
L
S
N
S
L
G
S
K
A
Y
L
R
V
D
V
N
Q
A
W
D
E
Q
V
A
S
V
Y
I
P
E
L
E
A
-
L
-
G
V
E
L
I
E
Q
P
V
G
R
E
N
-
T
Q
A
L
R
R
L
S
--
D
N
N
R
--
V
A
I
M
A
D
E
S
L
S
T
L
A
S
A
F
D
L
A
R
D
R
S
V
D
V
F
S
L
K
L
C
N
M
G
G
V
S
A
T
Q
K
I
A
A
V
A
E
A
S
G
I
A
S
Y
G
G
T
M
L
D
S
T
I
G
T
S
V
A
L
----------
Q
L
Y
S
T
V
P
S
-
L
P
F
G
C
E
L
I
--
G
-
P
--
F
-
V
L
A
D
T
L
-
S
-
H
-
E
P
--
L
E
---
I
---
R
D
Y
E
L
Q
V
P
T
G
V
G
H
G
M
T
L
D
E
D
K
V
R
Q
Y
-
A
R
-----
46
HHSearch
45.94
22%
-101
- C1 -
4H83
3
?
A:
[20-385]
L
T
I
T
R
I
E
T
I
P
M
V
A
P
L
----------
M
T
H
R
A
T
I
V
T
R
V
H
T
D
A
G
I
I
G
E
A
Y
T
G
D
--------------
E
--
H
E
T
M
F
----
D
I
D
R
I
I
H
E
E
L
A
-----
P
T
L
---
I
G
Q
D
A
M
A
I
E
R
L
W
D
S
G
YKVTFDILR
D
------------
R
R
L
G
L
-----------------
V
-------------
A
L
A
A
V
N
T
A
I
W
D
A
V
G
K
A
L
K
M
P
L
W
K
L
W
G
G
Y
R
N
-
E
-
L
P
M
I
A
I
G
G
Y
Y
G
E
P
L
---
G
S
I
--
A
D
E
M
H
N
-
Y
Q
E
L
G
L
A
G
V
K
F
K
V
G
G
L
S
A
--
A
E
D
A
A
R
I
T
A
A
R
E
A
A
G
D
D
F
I
I
C
I
D
A
N
Q
G
Y
K
P
A
V
A
V
D
L
S
R
R
I
A
D
-
L
-
N
I
R
W
F
E
E
P
V
E
W
H
N
D
K
R
S
M
R
D
V
R
--
Y
Q
G
S
--
V
P
V
C
A
G
Q
T
E
F
S
A
S
G
C
R
D
L
M
E
T
G
A
I
D
V
C
N
F
D
S
S
W
S
G
G
P
T
A
W
L
R
T
A
A
I
A
T
S
Y
D
V
Q
M
G
H
H
E
E
-
P
-----
Q
V
S
T
----------
H
L
L
A
S
Q
P
H
-
G
T
I
-
A
E
C
F
H
P
D
-
R
-
D
P
-
F
W
-
W
N
M
-
I
-
T
-
N
R
--
P
K
---
L
---
N
N
G
T
L
T
L
S
D
R
P
G
L
G
W
D
L
N
W
D
Y
I
D
Q
Y
-
R
V
-----
12
PsiBlast_PDB
45.91
24%
-98
- C1 -
3OZM
3
?
A:
[28-377]
-----------------------
G
L
K
L
N
R
Q
M
I
L
V
E
V
R
T
D
E
G
V
T
G
V
G
S
P
S
G
--------------
P
YD
L
A
-------
V
L
K
R
A
I
E
D
V
I
G
-----
P
Q
L
---
I
G
E
D
P
A
N
I
N
Y
L
----------------------------
W
H
K
V
F
H
G
EVSRNLGHRS
V
G
I
A
-------------
A
M
S
G
V
D
I
A
L
W
D
L
K
G
R
A
M
N
Q
P
I
Y
Q
L
L
G
G
K
F
H
T
R
G
V
R
A
Y
A
S
S
I
Y
W
D
L
T
P
-----
D
Q
A
A
D
E
L
A
G
-
W
V
E
Q
G
F
T
A
A
K
L
K
V
G
-
R
-
A
P
-
R
K
D
A
A
N
L
R
A
M
R
Q
R
V
G
A
D
V
E
I
L
V
D
A
N
Q
S
L
G
R
H
D
A
L
A
M
L
R
I
L
D
E
-
A
-
G
C
Y
W
F
E
E
P
L
S
I
D
D
-
I
E
G
H
R
I
L
R
--
A
Q
G
T
P-
V
R
I
A
T
G
E
N
L
Y
T
R
N
A
F
N
D
Y
I
R
N
D
A
I
D
V
L
Q
A
D
A
S
R
A
G
G
I
T
E
A
L
A
I
S
A
S
A
A
S
A
H
L
A
W
N
P
H
T
F
-
N
D
I
I
T
V
A
A
N
L
----------
H
L
V
A
A
S
P
---------
H
P
A
M
-
F
-
E
W
D
I
T
H
N
D
L
M
T
R
L
-
A
S
Y
D
L
K
---
L
---
E
N
G
L
V
Q
P
P
Q
G
P
G
L
G
F
E
I
D
W
D
F
V
A
A
H
-
A
W
K
G
---
38
HHSearch
44.92
21%
-99
- C1 -
1NU5
2
TCBD_PSESQ
A:
[1-369]
M
K
I
E
A
I
S
T
T
I
V
D
V
P
T
R
R
P
L
Q
M
S
F
T
T
V
H
K
Q
S
Y
V
I
V
Q
V
-
K
A
G
G
L
V
G
I
G
E
G
G
S
--------------
V
GG
P
T
WGSES
A
E
T
I
K
V
I
I
D
N
Y
L
A
-----
P
L
L
---
V
G
K
D
A
S
N
L
S
Q
A
R
V
L
M
D
R
-------
A
------------
V
T
G
N
L
-----------------
S
-------------
A
K
A
A
I
D
I
A
L
H
D
L
K
A
R
A
L
N
L
S
I
A
D
L
I
G
G
T
M
R
T
S
-
I
P
I
A
W
T
L
A
-
S
G
D
T
----
A
R
D
--
I
D
S
A
L
E
M
I
E
T
R
R
H
N
R
F
K
V
K
L
G
A
R
--
T
P
A
Q
D
L
E
H
I
R
S
I
V
K
A
V
G
D
R
A
S
V
R
V
D
V
N
Q
G
W
D
E
Q
T
A
S
I
W
I
P
R
L
E
E
-
A
-
G
V
E
L
V
E
Q
P
V
P
R
A
N
-
F
G
A
L
R
R
L
T
--
E
Q
N
G
--
V
A
I
L
A
D
E
S
L
S
S
L
S
S
A
F
E
L
A
R
D
H
A
V
D
A
F
S
L
K
L
C
N
M
G
G
I
A
N
T
L
K
V
A
A
V
A
E
A
A
G
I
S
S
Y
G
G
T
M
L
D
S
T
V
G
T
A
A
A
L
----------
H
V
Y
A
T
L
P
S
-
L
P
Y
-
G
C
E
L
----
I
-
G
P
W
V
L
G
D
R
L
-
T
-
Q
-
Q
D
--
L
E
---
I
---
K
D
F
E
V
H
L
P
L
G
S
G
L
G
V
D
L
D
H
D
K
V
R
H
Y
-
T
R
A
----