@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu14880: (2016-06-23 )
MTNQTARSSKKERYANLIPMEELHSEKDRLFPFPIYDKLRRESPVRYDPLRDCWDVFKYDDVQFVLKNPKLFSSKRGIQTESILTMDPPKHTKLRALVSRAFTPKAVKQLETRIKDVTAFLLQEARQKSTIDIIEDFAGPLPVIIIAEMLGAPIEDRHLIKTYSDVLVAGAKDSSDKAVADMVHNRRDGHAFLSDYFRDILSKRRAEPKEDLMTMLLQAEIDGEYLTEEQLIGFCILLLVAGNETTTNLIANAVRYLTEDSVVQQQVRQNTDNVANVIEETLRYYSPVQAIGRVATEDTELGGVFIKKGSSVISWIASANRDEDKFCKPDCFKIDRPSYPHLSFGFGIHFCLGAPLARLEANIALSSLLSMSACIEKAAHDEKLEAIPSPFVFGVKRLPVRITFK
Atome Classification :
(71 SA)
.........10........20........30........40...---..--------...50--.-.--.---------......60........70-----------------------....--.-----.------------.---------.------.80---------.-----------.----------..------.---------....90........100.......110....-----...120..--.-..-..130.......140.......150..-.....160-.......-.170-----.......180.......190---------..---.....200......-.210......-.220........230.......240.......250..-.....260.......270.--..-....280......-.-290-.-.--.......300........310.......320.......330....-..--.-340..-.....350.......360.......370.......380.......390.......400...-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTN
Q
T
A
R
S
S
K
K
E
R
Y
ANLI
P
M
E
E
L
HSEKDRLFPF
P
I
Y
D
K
L
RRESP---VR--------YD
P
L
---
R
-
D
--
C
---------
W
D
V
FKYD
D
V
Q
F
V
LKNPK------------------------LFSS--K-----R------------G---------I------QT----------E-----------
S
----------
I
L
------T---------MDPP
K
H
T
K
L
R
A
L
V
S
RAF
T
P
K
A
V
K
Q
L
E
T
R
I
K
D
-----
V
T
A
F
L
L
Q
E
--
A
-RQ-K
S
T
I
D
I
I
E
D
FAGP
L
P
V
I
I
I
A
E
M
LGAPI-E
D
R
H
L
I
K
--
T
Y
S
D
V
L
V
-AGAK-----DSS
D
K
A
V
A
D
M
V
HNRRD
G
H
A
F
---------
L
S
---
D
Y
F
R
D
I
L
S
KRRAE
P
-
K
E
D
L
M
T
M
L
L
Q
-AEI-DGEYL
T
E
E
Q
L
I
G
F
C
I
L
L
LVAGN
E
T
T
T
N
L
I
A
N
A
V
-
R
Y
LTE
D
S
V
V
Q
Q
Q
V
R
QNT
D
N
--
V
A
-
N
V
I
E
E
T
L
R
Y
Y
S
P
V
-
Q
-
A
---
I
-
G
--
R
VATEDTEL-
G
G
V
F
I
KKG
S
S
V
I
S
W
I
A
SANRDEDKFCKPD
C
F
KIDR-PS--Y-PHLSF-GFG
I
H
F
CLGA
P
L
A
R
L
E
A
N
I
A
L
S
S
L
L
S
M
S
A
C
I
E
K
AA
H
D
E
K
L
E
AIPS
P
F
V
F
GVKRL
P
V
R
I
TFK-
1
PsiBlast_PDB
79.16
43%
-127
- C5 -
4RM4
1
YJIB_BACSU
A:
[22-396]
---------------------------
D
A
Y
H
P
F
P
W
Y
E
S
M
R
K
D
A
P
---
V
S
--------
F
D
E
E
---
N
-
Q
--
V
---------
W
S
V
F
L
Y
D
D
V
K
K
V
V
G
D
K
E
------------------------
L
F
S
S
--
C
-----
M
-------------------------------G---------
N
-----------
S
----------
I
I
------
N
---------
M
D
P
P
K
H
T
K
I
R
S
V
V
N
K
A
F
T
P
R
V
M
K
Q
W
E
P
R
I
Q
E
-----
I
T
D
E
L
I
Q
K
--
F
-
Q
G
-
R
S
E
F
D
L
V
H
D
F
S
Y
P
L
P
V
I
V
I
S
E
L
L
G
V
P
S
-
A
H
M
E
Q
F
K
--
A
W
S
D
L
L
V
-
S
T
P
K
-----
D
K
S
E
E
A
E
K
A
F
L
E
E
R
D
K
C
E
E
E
---------
L
A
---
A
F
F
A
G
I
I
E
E
K
R
N
K
P
-
E
Q
D
I
I
S
I
L
V
E
------
G
E
K
L
S
G
E
E
L
I
P
F
C
T
L
L
L
V
A
G
N
E
T
T
T
N
L
I
S
N
A
M
-
Y
S
I
L
E
T
P
G
V
Y
E
E
L
R
S
H
P
E
L
--
M
P
-
Q
A
V
E
E
A
L
R
F
R
A
P
A
-
P
-
V
---
L
-
R
--
R
I
A
K
R
D
T
E
I
-
G
G
H
L
I
K
E
G
D
M
V
L
A
F
V
A
S
A
N
R
D
E
A
K
F
D
R
P
H
M
F
D
I
R
R
-
H
P
--
N
-
P
H
I
A
F
-
G
H
G
I
H
F
C
L
G
A
P
L
A
R
L
E
A
N
I
A
L
T
S
L
I
S
A
F
P
H
M
E
C
V
S
----
I
T
P
I
E
N
S
V
I
Y
G
L
K
S
F
R
V
K
M
----
2
PsiBlast_PDB
77.76
37%
-118
- C5 -
4GGV
1
?
A:
[42-418]
---------------------------------------
R
P
E
S
P
---
V
V
--------
F
D
E
T
---
Q
-
G
--
V
---------
W
N
V
Y
G
Y
P
E
A
M
D
I
L
N
D
H
D
------------------------
T
F
T
S
--
D
-----
L
------------
A
HLLP-----
V
------
S
V
----------
D
-----------
A
----------
P
L
LEGDMS
Q
---------
M
D
P
P
R
H
R
K
Y
R
Q
L
V
S
R
A
F
T
P
R
L
V
A
D
M
E
T
R
V
A
D
-----
I
T
R
E
L
L
D
A
--
V
-
D
G
-
K
P
E
I
E
I
A
A
D
L
A
Y
P
L
P
V
I
V
I
A
E
L
L
G
V
P
A
-
G
D
R
D
L
F
K
--
K
W
A
D
D
I
I
-
E
G
F
S
GFSFL
D
T
S
G
Q
G
E
Q
D
-
V
R
D
A
T
E
R
L
R
P
---------
L
L
---
D
Y
M
A
G
H
V
T
E
R
R
R
T
P
-
R
E
D
L
L
T
H
L
V
Q
-
A
E
V
-
D
G
E
R
L
T
D
N
E
I
V
N
V
A
N
I
L
L
V
T
G
H
I
T
T
T
M
T
L
G
N
T
V
-
L
C
L
D
A
D
P
E
V
A
A
K
V
R
A
D
R
S
L
--
V
P
-
G
A
I
E
E
A
L
R
V
L
S
P
S
-
A
-
A
---
L
-
A
--
R
G
T
S
R
E
V
E
V
-
A
G
T
V
I
P
K
D
Q
I
V
M
L
W
L
G
A
G
N
R
D
P
R
Q
F
T
D
P
E
V
Y
D
P
T
R
-
D
P
--
N
-
P
H
F
G
F
-
G
R
G
I
H
F
C
L
G
A
P
L
A
R
L
E
G
R
V
A
L
N
A
L
F
D
R
F
P
V
L
-
R
T
D
P
A
K
P
P
T
F
F
P
T
P
D
M
I
G
V
N
T
L
H
L
R
T
S
---
75
PsiBlast_CBE
76.77
35%
-129
- C5 -
3A51
8
CPVDH_PSEAH
A:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
G
P
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
78
PsiBlast_CBE
76.11
35%
-126
- C5 -
3A50
5
CPVDH_PSEAH
C:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
GP
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
101
PsiBlast_CBE
75.93
34%
-120
- C5 -
2Z3U
8
?
A:
[16-394]
-------------------------
K
K
D
I
A
D
P
Y
P
V
Y
R
R
Y
R
E
A
A
P
---
V
H
R
T
A
-----
S
G
P
G
---
K
P
D
--
T
---------
Y
Y
V
F
T
Y
D
D
V
V
R
V
L
S
N
R
R
------------------------
L
G
R
N
--
A
-----
R
V
A
S
GDTDTAPV-
P
---------
I
------
P
T
----------
E
-----------
H
R
A
L
R
T
V
V
E
N
W
L
V
------
F
---------
L
D
P
P
H
H
T
E
L
R
S
L
L
T
T
E
F
S
P
S
I
V
T
G
L
R
P
R
I
A
E
-----
L
A
S
A
L
L
D
R
--
L
-
R
A
-
Q
R
R
P
D
L
V
E
G
F
A
A
P
L
P
I
L
V
I
S
A
L
L
G
I
P
E
-
E
D
H
T
W
L
R
--
A
N
A
---
V
-
A
L
Q
E
-----
A
S
T
T
R
A
--------
R
D
G
R
G
Y
A
R
A
E
A
A
S
Q
E
F
T
---
R
Y
F
R
R
E
V
D
R
R
G
G
D
D
-
R
D
D
L
L
T
L
L
V
R
-
A
R
D
-
T
G
S
P
L
S
V
D
G
I
V
G
T
C
V
H
L
L
T
A
G
H
E
T
T
T
N
F
L
A
K
A
V
-
L
T
L
R
A
H
R
D
V
L
D
E
L
R
T
T
P
E
S
--
T
P
-
A
A
V
E
E
L
M
R
Y
D
P
P
V
-
Q
-
A
---
V
-
T
--
R
W
A
Y
E
D
I
R
L
-
G
D
H
D
I
P
R
G
S
R
V
V
A
L
L
G
S
A
N
R
D
P
A
R
F
P
D
P
D
V
L
D
V
H
R
-
A
A
--
E
-
R
Q
V
G
F
-
G
L
G
I
H
Y
C
L
G
A
T
L
A
R
A
E
A
E
I
G
L
R
A
L
L
D
G
I
P
A
L
G
R
G
A
H
E
-------------------------
83
PsiBlast_CBE
75.89
35%
-126
- C5 -
3A4Z
4
CPVDH_PSEAH
C:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
GP
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
73
PsiBlast_CBE
75.83
35%
-127
- C5 -
3A51
5
CPVDH_PSEAH
C:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
GP
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
74
PsiBlast_CBE
75.75
35%
-126
- C5 -
3A51
3
CPVDH_PSEAH
B:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
GP
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
84
PsiBlast_CBE
75.62
35%
-125
- C5 -
3A4Z
2
CPVDH_PSEAH
B:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
GP
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
88
PsiBlast_CBE
75.57
32%
-116
- C5 -
4Z5P
2
?
B:
[8-398]
--------------
V
H
I
Y
P
F
E
---
G
E
V
D
G
L
E
I
H
P
K
F
A
E
L
R
E
T
D
P
LAR
V
R
--------
L
P
Y
G
---
G
-
E
--
G
---------
W
M
V
T
R
Y
D
D
V
R
A
A
N
S
D
P
R
------------------------
F
S
R
A
--
Q
-----
I
------------
G
---------
E
------
D
T
PRTTP-----
D
-----------
T
----------
I
L
------
S
---------
L
D
P
P
E
H
T
R
L
R
R
L
L
S
K
A
F
T
A
R
R
M
G
A
M
Q
S
W
L
E
E
-----
L
F
A
G
L
L
D
G
--
V
E
R
T
-
G
H
P
A
D
I
V
R
D
L
A
Q
P
F
T
I
A
V
I
C
R
L
L
G
V
P
Y
-
E
D
R
G
R
F
Q
--
H
W
S
E
V
I
M
-
S
T
T
A
-----
Y
S
K
E
E
A
V
S
--------
A
D
A
S
---------
I
R
---
A
Y
L
A
D
L
V
S
A
R
R
A
A
P
-
H
D
D
L
L
G
V
L
V
S
-
A
R
D
-
D
D
D
R
L
T
E
D
E
L
I
T
F
G
V
T
L
L
V
A
G
H
E
T
S
A
H
Q
L
G
N
M
V
-
Y
A
L
L
T
H
E
D
Q
L
S
L
L
R
E
Q
P
E
L
--
L
P
-
R
A
V
E
E
L
L
R
F
V
P
L
G
-
N
-
G
---
V
-
G
NA
R
I
A
L
E
D
V
E
L
-
S
G
G
T
V
R
A
G
E
G
V
V
A
A
A
V
N
A
N
R
D
P
R
A
F
D
D
P
D
R
L
D
I
T
R
-
E
K
--
N
-
P
H
L
A
F
-
G
H
G
A
H
Y
C
L
G
A
Q
L
A
R
M
E
L
R
V
A
I
G
G
L
L
E
R
F
P
G
L
R
L
A
V
P
A
D
Q
V
E
W
K
T
G
G
L
F
R
G
P
Q
R
L
P
I
------
105
PsiBlast_CBE
75.34
32%
-119
- C5 -
4TRI
3
?
B:
[57-394]
--------------------------------------------------------------------------------------------
R
N
P
E
------------------------
L
F
S
S
--
T
-----
G
------------
G
---------
I
------
R
P
----------
D
-----------
Q
PGMPY-----
M
I
------
D
---------
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
-----
L
C
D
T
L
I
D
A
--
V
-
C
E
-
R
G
E
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
-
T
E
R
D
M
L
L
--
K
W
S
D
D
L
V
-
C
G
L
S
-----
S
H
V
D
E
A
A
---
I
Q
K
L
M
D
T
F
A
A
---------
Y
T
---
E
F
T
K
D
V
I
T
K
R
R
A
E
P
-
T
D
D
L
F
S
V
L
V
N
-
S
E
V
-
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
-
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
V
D
L
--
L
P
-
G
A
I
E
E
M
L
R
W
T
S
P
V
-
K
-
N
---
M
-
C
--
R
T
L
T
A
D
T
V
F
-
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
-
N
P
--
N
-
S
H
V
A
F
-
G
F
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
-
R
L
A
D
D
A
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
---
3
PsiBlast_PDB
75.34
36%
-122
- C5 -
4YT3
3
?
A:
[22-384]
-------------------------------
P
Y
A
W
C
K
R
M
L
E
N
D
P
---
V
S
--------
Y
H
E
G
---
T
-
D
--
T
---------
W
N
V
F
K
Y
E
D
V
K
R
V
L
S
D
Y
K
------------------------
H
F
S
S
--
V
-----
R
------------
K
------------------------------------------------------------VPEKIQITE
S
D
P
P
D
H
R
K
R
R
S
L
L
A
A
A
F
T
P
R
S
L
Q
N
W
E
P
R
I
Q
E
-----
I
A
D
E
L
I
G
Q
--
M
-
D
G
--
T
E
I
D
I
V
A
S
L
A
S
P
L
P
I
I
V
M
A
D
L
M
G
V
P
S
-
K
D
R
L
L
F
K
--
K
W
V
D
T
L
F
-
L
P
F
---------
Q
E
E
V
D
K
L
---
K
Q
V
A
A
K
E
---------
Y
Y
---
Q
Y
L
Y
P
I
V
V
Q
K
R
L
N
P
-
A
D
D
I
I
S
D
L
L
K
-
S
E
V
-
D
G
E
M
F
T
D
D
E
V
V
R
T
T
M
L
I
L
G
A
G
V
E
T
T
S
H
L
L
A
N
S
F
Y
S
L
L
Y
D
D
K
E
V
Y
Q
E
L
H
E
N
L
D
L
--
V
P
-
Q
A
V
E
E
M
L
R
F
R
F
N
L
-
I
-
K
---
L
-
D
--
R
T
V
K
E
D
N
D
L
-
L
G
V
E
L
K
E
G
D
S
V
V
V
W
M
S
A
A
N
M
D
E
E
M
F
E
D
P
F
T
L
N
I
H
R
-
P
N
--
N
K
K
H
L
T
F
-
G
N
G
P
H
F
C
L
G
A
P
L
A
R
L
E
A
K
I
A
L
T
A
F
L
------
K
K
F
K
H
---
I
E
A
V
P
S
-----------------
21
PsiBlast_CBE
75.32
36%
-126
- C5 -
4YT3
2
?
B:
[22-384]
-------------------------------
P
Y
A
W
C
K
R
M
L
E
N
D
P
---
V
S
--------
Y
H
E
G
---
T
-
D
--
T
---------
W
N
V
F
K
Y
E
D
V
K
R
V
L
S
D
Y
K
------------------------
H
F
S
S
--
V
-----
R
-------------------------------------------------------------------------VPEKIQITE
S
D
P
P
D
H
R
K
R
R
S
L
L
A
A
A
F
T
P
R
S
L
Q
N
W
E
P
R
I
Q
E
-----
I
A
D
E
L
I
G
Q
--
M
-
D
G
-
G
T
E
I
D
I
V
A
S
L
A
S
P
L
P
I
I
V
M
A
D
L
M
G
V
P
S
-
K
D
R
L
L
F
K
--
K
W
V
D
T
L
F
-
L
P
F
---------
Q
E
E
V
D
K
L
---
K
Q
V
A
A
K
E
---------
Y
Y
---
Q
Y
L
Y
P
I
V
V
Q
K
R
L
N
P
-
A
D
D
I
I
S
D
L
L
K
-
S
E
V
-
D
G
E
M
F
T
D
D
E
V
V
R
T
T
M
L
I
L
G
A
G
V
E
T
T
S
H
L
L
A
N
S
F
Y
S
L
L
Y
D
D
K
E
V
Y
Q
E
L
H
E
N
L
D
L
--
V
P
-
Q
A
V
E
E
M
L
R
F
R
F
N
L
-
I
-
K
---
L
-
D
--
R
T
V
K
E
D
N
D
L
-
L
G
V
E
L
K
E
G
D
S
V
V
V
W
M
S
A
A
N
M
D
E
E
M
F
E
D
P
F
T
L
N
I
H
R
-
P
N
--
N
K
K
H
L
T
F
-
G
N
G
P
H
F
C
L
G
A
P
L
A
R
L
E
A
K
I
A
L
T
A
F
L
------
K
K
F
K
H
---
I
E
A
V
P
S
-----------------
87
PsiBlast_CBE
75.31
35%
-125
- C5 -
3A4G
2
CPVDH_PSEAH
A:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
G
P
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HTLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
E
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
79
PsiBlast_CBE
75.23
35%
-124
- C5 -
3A50
2
CPVDH_PSEAH
B:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
GP
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
71
PsiBlast_CBE
75.21
35%
-123
- C5 -
3A51
4
CPVDH_PSEAH
E:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
GP
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
76
PsiBlast_CBE
75.11
35%
-124
- C5 -
3A50
4
CPVDH_PSEAH
E:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
GP
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
80
PsiBlast_CBE
75.10
35%
-126
- C5 -
3A50
8
CPVDH_PSEAH
A:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
G
P
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
86
PsiBlast_CBE
74.98
35%
-122
- C5 -
3A4H
2
CPVDH_PSEAH
A:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
G
P
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HTLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
E
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
85
PsiBlast_CBE
74.98
35%
-124
- C5 -
3A4Z
7
CPVDH_PSEAH
A:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
G
P
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----