@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu16670: (2016-06-26 )
MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQIAEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVFASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTEQDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNSYIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAIKIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70.--...----.....80........90........100.......110...-.--...120.......130.......140.......150...--.....160.......170.......180.......190.......200-..-.....210.....-.-.220-......-------.230.-.------------...-----..240.......250.......260.......270........280.......290.......300.......310....--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
T
I
HITH
P
H
H
L
I
K
E
E
Q
A
K
S
V
M
A
L
G
YFDGVHLG
H
Q
K
V
I
G
T
A
K
Q
I
A
E
EKG
L
T
L
A
V
M
T
FHPH
P
S
H
VLGRDKE-
P
--
K
D
L
----IT
P
L
E
D
K
I
N
Q
I
E
Q
LGT
E
V
L
Y
V
V
K
F
N
E
V
F
ASL
S
P
K
Q
F
I
D
Q
Y
I
-
I
--GLN
V
Q
H
AVAGFDFTYGKYGKGTMKTMPDDLDGKA-
G
C
T
M
--
V
E
K
L
T
E
Q
D
K
K
I
S
S
S
Y
I
R
T
A
L
QNG
D
V
E
L
A
N
V
LLGQ
P
Y
F
I
K
G
I
V
I
HGDKR-G
R
-
T
IGFPTANVGLNN-
S
-
Y
I
VP-PT
G
V
Y
A
-------
V
K
A
E
V-N------------G
E
V
-----YN
G
V
CNIGYKPTFYEKRPEQP
S
I
E
V
N
L
F
DFNQEV-Y
G
A
A
I
K
I
E
W
Y
K
R
I
R
S
ERKFN
G
I
K
E
L
T
E
Q
I
E
K
D
K
Q
E
A
I
R
Y
F
S
NLRK--
44
HHSearch
88.47
30%
-111
* C4 *
2X0K
3
RIBF_CORAM
A:
[1-321]
M
D
I
W
Y
G
T
A
A
---
V
P
K
D
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
-
P
--
L
-
G
----
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
E
F
L
L
E
D
--
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
-
R
L
T
V
D
V
--
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
-
G
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
-
V
A
L
P
-
A
D
G
V
Y
A
-------
G
W
L
T
I
-
L
PTEAPVSGNMEP
E
V
A
-----
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
---
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
D
----
1
PsiBlast_PDB
87.73
37%
-121
- C4 -
3OP1
10
?
A:
[20-308]
-----------------
S
D
S
V
V
V
L
G
Y
F
D
G
I
H
K
G
H
Q
E
L
F
R
V
A
N
K
A
A
R
K
D
L
L
P
I
V
V
M
T
F
N
E
S
P
K
I
A
L
----
E
-
P
YH
P
D
L
FLHI
L
N
P
A
E
-
R
E
R
K
L
K
R
E
G
V
E
E
L
Y
L
L
D
F
S
S
Q
F
A
S
L
T
A
Q
E
F
F
A
T
Y
I
-
K
--
A
M
N
A
K
I
I
V
A
G
F
D
Y
T
F
G
S
-
D
K
K
T
A
E
D
L
K
N
Y
F
D
G
E
---
V
I
I
--
V
P
P
V
E
D
E
K
G
K
I
S
S
T
R
I
R
Q
A
I
L
D
G
N
V
K
E
A
G
K
L
L
G
A
P
L
P
S
R
G
M
V
V
H
G
N
--------
G
Y
P
T
A
N
L
V
L
L
D
-
R
-
T
Y
M
P
-
A
D
G
V
Y
V
-------
V
D
V
E
I
-
Q
------------
R
Q
K
-----
Y
R
A
M
A
S
V
G
K
N
V
T
F
---
D
--
E
A
R
F
E
V
N
I
F
D
F
N
Q
D
I
-
Y
G
E
T
V
M
V
Y
W
L
D
R
I
R
D
M
T
K
F
D
S
V
D
Q
L
V
D
Q
L
K
A
D
-
E
E
V
T
R
N
W
S
------
45
HHSearch
85.98
35%
-111
- C4 -
3OP1
10
?
A:
[16-307]
-------------
I
G
T
P
S
D
S
V
V
V
L
G
Y
F
D
G
I
H
K
G
H
Q
E
L
F
R
V
A
N
K
A
A
R
K
D
L
L
P
I
V
V
M
T
F
N
E
S
P
K
I
A
L
E
P
Y
H
P
D
L
--
F
L
H
----
I
L
N
P
A
E
R
E
R
K
L
K
R
E
G
V
E
E
L
Y
L
L
D
F
S
S
Q
F
A
S
L
T
A
Q
E
F
F
A
T
Y
I
-
K
--
A
M
N
A
K
I
I
V
A
G
F
D
Y
T
F
G
S
D
K
K
-
T
A
E
D
L
K
N
Y
---
F
D
G
E
V
I
I
--
V
P
P
V
E
D
E
K
G
K
I
S
S
T
R
I
R
Q
A
I
L
D
G
N
V
K
E
A
G
K
L
L
G
A
P
L
P
S
R
G
M
V
V
H
G
N
--------
G
Y
P
T
A
N
L
V
L
L
D
-
R
-
T
Y
M
P
-
A
D
G
V
Y
V
-------
V
D
V
E
I
-
Q
------------
R
Q
K
-----
Y
R
A
M
A
S
V
G
K
N
V
T
F
D
-----
E
A
R
F
E
V
N
I
F
D
F
-
N
Q
D
I
Y
G
E
T
V
M
V
Y
W
L
D
R
I
R
D
M
T
K
F
D
S
V
D
Q
L
V
D
Q
L
K
A
D
E
E
V
T
R
N
W
--------
21
PsiBlast_CBE
84.06
31%
-110
- C4 -
2X0K
3
RIBF_CORAM
B:
[17-313]
-------------------
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
-
P
--
L
G
-----
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
-
L
ED
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
R
L
-
T
V
D
V
--
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
K
-
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
-
V
A
L
P
-
A
D
G
V
Y
A
GWLTILP
T
E
A
P
V
-
S
------------
G
N
M
EPEVA
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
---
E
Q
R
S
V
E
S
F
V
L
D
R
D
A
D
L
-
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
------------
2
PsiBlast_PDB
83.84
31%
-113
- C4 -
2X0K
3
RIBF_CORAM
A:
[17-313]
-------------------
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
-
P
--
L
G
-----
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
-
L
ED
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
R
L
-
T
V
D
V
--
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
K
-
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
-
V
A
L
P
-
A
D
G
V
Y
A
G
W
L
T
ILP
T
E
A
P
V
-
S
------------
G
N
M
EPE
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
---
E
Q
R
S
V
E
S
F
V
L
D
R
D
A
D
L
-
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
------------
3
PsiBlast_PDB
83.10
31%
-112
- C4 -
4UZF
3
RIBF_CORAM
A:
[17-313]
-------------------
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
E
A
-
P
--
L
G
-----
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
-
L
ED
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
R
L
-
T
V
D
V
--
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
K
-
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
-
V
A
L
P
-
A
D
G
V
Y
A
G
W
L
T
ILP
T
E
A
P
V
-
S
------------
G
N
M
EPE
V
A
Y
A
A
A
I
S
V
G
T
N
P
-------
E
Q
R
S
V
E
S
F
V
L
D
R
D
A
D
L
-
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
------------
46
HHSearch
82.58
33%
-141
- C4 -
1MRZ
1
?
A:
[2-284]
--------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
P
D
-
F
--
P
--
G
-
L
----
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
--
R
T
V
V
L
D
F
F
-
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
L
-
S
----
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
----
G
V
E
V
Y
E
--
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
R
G
N
-
E
K
L
V
D
L
-
K
R
G
V
Y
L
-------
V
R
V
H
L
P
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
R
--------
R
N
V
K
Y
E
V
Y
I
L
D
F
-
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
----
10
PsiBlast_PDB
82.00
34%
-137
- C4 -
1S4M
2
?
A:
[2-277]
--------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
---
P
D
-
F
--
P
G
L
----
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
R
T
V
--
V
L
D
F
F
R
I
-
K
D
L
T
P
E
G
F
V
E
R
Y
L
-
S
--
G
--
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
-----
K
K
-
G
V
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-
H
K
----------
F
P
T
A
N
I
D
R
G
N
-
E
-
K
L
V
D
L
K
R
G
V
Y
L
-------
V
R
V
H
L
P
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
R
P
T
--
D
A
R
--
N
V
K
Y
E
V
Y
I
L
D
F
E
G
D
L
-
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
-----------
34
Fugue
81.99
32%
-146
- C4 -
1MRZ
1
?
A:
[2-288]
--------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
---
P
D
-
F
--
P
G
L
----
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
--
R
T
V
V
L
D
F
F
R
I
-
K
D
L
T
P
E
G
F
V
E
R
Y
L
-
S
--
G
--
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
---
G
V
-
E
V
Y
E
--
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
R
G
N
E
K
-
L
V
D
L
-
K
R
G
V
Y
L
-------
V
R
V
H
L
P
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
R
R
N
--------
V
K
Y
E
V
Y
I
L
D
F
E
G
D
L
-
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
N
S
K
5
PsiBlast_PDB
81.84
30%
-113
- C4 -
3ZUG
3
RIBF_CORAM
A:
[17-313]
-------------------
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
-
P
--
L
G
-----
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
-
L
ED
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
R
L
-
T
V
D
V
--
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
K
-
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
-
V
A
L
P
-
A
D
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
V
-
S
------------
G
N
M
EPE
V
A
Y
A
A
A
I
S
V
G
T
N
P
---
D
---
E
Q
R
S
V
D
S
F
V
L
D
R
D
A
D
L
-
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
------------
4
PsiBlast_PDB
81.72
31%
-109
- C4 -
4UZE
3
RIBF_CORAM
A:
[17-313]
-------------------
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
A
A
-
P
--
L
G
-----
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
-
L
ED
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
R
L
-
T
V
D
V
--
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
K
-
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
-
V
A
L
P
-
A
D
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
V
-
S
------------
G
N
M
EPE
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
---
E
Q
R
S
V
E
S
F
V
L
D
R
D
A
D
L
-
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
------------
6
PsiBlast_PDB
81.42
34%
-136
- C4 -
1MRZ
1
?
A:
[2-277]
--------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
---
P
D
-
F
--
P
G
L
----
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
R
T
V
--
V
L
D
F
F
R
I
-
K
D
L
T
P
E
G
F
V
E
R
Y
L
-
S
--
G
--
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
-----
K
K
-
G
V
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
R
G
N
-
E
-
K
L
V
D
L
K
R
G
V
Y
L
-------
V
R
V
H
L
P
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
R
------
R
--
N
V
K
Y
E
V
Y
I
L
D
F
E
G
D
L
-
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
-----------
7
PsiBlast_PDB
80.74
34%
-131
- C4 -
1T6X
1
?
A:
[2-277]
--------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
---
P
D
-
F
--
P
G
L
----
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
R
T
V
--
V
L
D
F
F
R
I
-
K
D
L
T
P
E
G
F
V
E
R
Y
L
-
S
--
G
--
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
-----
K
K
-
G
V
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
R
G
N
-
E
-
K
L
V
D
L
K
R
G
V
Y
L
-------
V
R
V
H
L
P
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
R
------
R
--
N
V
K
Y
E
V
Y
I
L
D
F
E
G
D
L
-
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
-----------
23
PsiBlast_CBE
80.73
31%
-110
- C4 -
4UZE
3
RIBF_CORAM
B:
[17-313]
-------------------
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
A
A
-
P
--
L
G
-----
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
-
L
ED
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
R
L
-
T
V
D
V
--
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
K
-
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
-
V
A
L
P
-
A
D
G
V
Y
A
G
W
L
T
ILP
T
E
A
P
V
-
S
------------
G
N
M
EPE
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
------
E
Q
R
S
V
E
S
F
V
L
D
R
D
A
D
L
-
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
------------
28
PsiBlast_CBE
80.35
34%
-140
- C4 -
1MRZ
2
?
B:
[2-277]
--------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
---
P
D
-
F
--
P
G
L
----
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
R
T
V
--
V
L
D
F
F
R
I
-
K
D
L
T
P
E
G
F
V
E
R
Y
L
-
S
--
G
--
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
-----
K
K
-
G
V
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-
H
-----------
F
P
T
A
N
I
D
R
G
N
-
E
-
K
L
V
D
L
K
R
G
V
Y
L
-------
V
R
V
H
L
P
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
----------
N
V
K
Y
E
V
Y
I
L
D
F
E
G
D
L
-
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
-----------
22
PsiBlast_CBE
80.19
31%
-112
- C4 -
4UZF
3
RIBF_CORAM
B:
[17-313]
-------------------
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
E
A
-
P
--
L
G
-----
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
-
L
ED
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
R
L
-
T
V
D
V
--
I
D
L
L
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
K
-
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
-
V
A
L
P
-
A
D
G
V
Y
A
G
W
L
T
ILP
T
E
A
P
V
-
S
------------
G
N
M
EPE
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
------
E
Q
R
S
V
E
S
F
V
L
D
R
D
A
D
L
-
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
------------
11
PsiBlast_PDB
80.10
34%
-135
- C4 -
2I1L
-
?
A:
[2-277]
--------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
---
P
D
-
F
--
P
G
L
----
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
R
T
V
--
V
L
D
F
F
R
I
-
K
D
L
T
P
E
G
F
V
E
R
Y
L
-
S
--
G
--
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
-----
K
K
-
G
V
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
R
G
N
-
E
-
K
L
V
D
L
K
R
G
V
Y
L
-------
V
R
V
H
L
P
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
R
---------
N
V
K
Y
E
V
Y
I
L
D
F
E
G
D
L
-
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
-----------
26
PsiBlast_CBE
80.05
34%
-135
- C4 -
1T6X
1
?
B:
[2-277]
--------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
---
P
D
-
F
--
P
G
L
----
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
R
T
V
--
V
L
D
F
F
R
I
-
K
D
L
T
P
E
G
F
V
E
R
Y
L
-
S
--
G
--
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
-----
K
K
-
G
V
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-
H
-----------
F
P
T
A
N
I
D
R
G
N
-
E
-
K
L
V
D
L
K
R
G
V
Y
L
-------
V
R
V
H
L
P
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
----------
N
V
K
Y
E
V
Y
I
L
D
F
E
G
D
L
-
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
-----------
24
PsiBlast_CBE
79.95
34%
-131
- C4 -
1T6Z
1
?
B:
[2-277]
--------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
---
P
D
-
F
--
P
G
L
----
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
R
T
V
--
V
L
D
F
F
R
I
-
K
D
L
T
P
E
G
F
V
E
R
Y
L
-
S
--
G
--
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
-----
K
K
-
G
V
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-
H
-----------
F
P
T
A
N
I
D
R
G
N
-
E
-
K
L
V
D
L
K
R
G
V
Y
L
-------
V
R
V
H
L
P
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
----------
N
V
K
Y
E
V
Y
I
L
D
F
E
G
D
L
-
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
-----------
27
PsiBlast_CBE
79.68
34%
-136
- C4 -
1S4M
1
?
B:
[2-277]
--------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
---
P
D
-
F
--
P
G
L
----
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
R
T
V
--
V
L
D
F
F
R
I
-
K
D
L
T
P
E
G
F
V
E
R
Y
L
-
S
--
G
--
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
-----
K
K
-
G
V
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-
H
K
----------
F
P
T
A
N
I
D
R
G
N
-
E
-
K
L
V
D
L
K
R
G
V
Y
L
-------
V
R
V
H
L
P
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
----------
N
V
K
Y
E
V
Y
I
L
D
F
E
G
D
L
-
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
-----------
25
PsiBlast_CBE
76.73
34%
-136
- C4 -
1T6Y
3
?
B:
[2-277]
--------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
---
P
D
-
F
--
P
G
L
----
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
R
T
V
--
V
L
D
F
F
R
I
-
K
D
L
T
P
E
G
F
V
E
R
Y
L
-
S
--
G
--
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
-----
K
K
-
G
V
E
V
Y
E
I
E
D
V
V
V
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-
H
-----------
F
P
T
A
N
I
D
R
G
N
-
E
-
K
L
V
D
L
K
R
G
V
Y
L
-------
V
R
V
H
L
P
D
------------
G
K
K
-----
K
F
G
V
M
N
V
G
F
----------
N
V
K
Y
E
V
Y
I
L
D
F
E
G
D
L
-
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
-----------