@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22920: (2016-07-05 )
MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFHELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEELLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRWMDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGKQISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGGHPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPVENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQVRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL
Atome Classification :
(20 SA)
-------------.........10........20..-......30........40........----------50........60.....------...70........80-........-90........100---.......110--------........120....-.-..-130.......-----140.......150.......160.......170-----------....-....-.180-.......190.......200.......210...---....220--.........230-------...-....-.240.......250---------...-....260-.......--270.-......280..--------...-----..290.......300-.......-.----.310-..-..------...320--------.-.--.......330.-.-.....340--------------..-------.....-350......----.360.......------370----.........380.......390-----.----------.---..-..---..400-..----.....-----410-----.-..-...---.----420-----.----........430--------........440.......450----------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------MI
R
G
I
L
I
A
V
L
G
I
A
I
V
GTGYWGYK-EHQEK
D
A
V
L
L
H
AEN
N
Y
Q
R
A
F
H
E
L
T
Y
Q
----------
V
D
Q
L
H
D
K
IG
T
T
L
AMNSQ------KSLS
P
A
L
I
D
V
W
R
I
T
S
-
E
AHN
S
V
S
Q-L
P
L
T
LMPFN
K
T
E
E
---
L
L
S
K
IGDFS---------YKTSVRDLDQKPLDK-N-E
Y
-
T
S
L
N
K
L
Y
Q
Q
S
-----
E
D
I
Q
N
E
L
R
H
V
Q
H
L
V
M
SKN
L
R
W
M
D
V
E
M
A
LASD-------------EKQS-D
N
T
I
-
I
N
S
F
-
K
T
V
E
K
NVGAFSTGTDLGPSFTST
K
K
E
EKGFSHL---KGKQI----
S
E
Q
E
A
K
Q
I
A
E
R--------FAP-DDN
Y
-
S
I
K
V
V
KSGKKTNR
D
---------
V
Y
S
-
I
SMKDPD-H
K
A
V
I
Y
M
--
D
ITK-KGGH
P
V
Y
L
IQN--------REV-----KD
Q
K
I
SLNDGSNR---
A
L
A
F
LKK-N----GFET-DD-LE------IDES----------A-Q--YDK
I
G
V
F
S
YVP-V-
E
N
K
V
R
MY
P
--------------
E
A
-------
I
R
M
K
V
-
A
LDDG
E
V
V
G
----
F
S
A
R
D
F
L
T
S
H
R
------K------RTIPKPAI
T
E
A
E
A
K
S
K
LNKN
V
------
Q
----------
V
---
R
E
-
T
R
---
L
A
L
I
T
-
N
E
----LG
Q
E
V
-----
L
C
Y
-----
E
-
M
L
-GTI---E----N-------D----
T
F
R
M
Y
I
NAKD---------G
S
E
E
K
V
E
K
LKNAEPIYKDL------------------------------------------------------------------
37
Fugue
90.57
54%
26
- C5 -
5BOI
2
?
A:
[7-232]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
E
V
----
S
E
D
V
A
K
Q
V
A
R
S
--------
F
L
N
L
K
G
N
E
-
Q
I
H
I
V
K
S
G
K
D
A
D
Y
E
---------
V
Y
S
-
L
T
I
T
D
P
K
-
T
N
Q
E
T
Y
M
--
D
I
T
Q
-
K
G
G
Y
P
L
W
V
L
E
D
--------
R
D
I
-----
K
K
Q
N
I
S
L
N
D
A
M
N
K
---
A
T
K
F
L
K
D
-
H
----
R
F
E
---
S
-
L
V
------
M
A
E
S
----------
A
-
Q
--
Y
D
N
M
G
V
F
T
F
V
E
Q
T
-
E
S
G
V
R
I
Y
P
--------------
D
S
-------
V
K
M
K
M
-
S
L
E
D
G
S
V
I
G
----
F
S
A
K
D
F
L
L
K
H
R
------
T
------
R
D
I
P
K
P
K
I
S
K
E
Q
A
K
T
K
L
N
S
N
V
------
K
----------
V
---
M
E
-
E
R
---
L
A
I
I
T
-
N
D
----
L
N
E
E
V
-----
L
C
Y
-----
E
-
F
L
-
G
T
I
---
K
----
N
-------
D
----
T
Y
R
I
F
I
N
A
D
T
---------
G
F
E
E
K
V
E
K
L
Q
N
--------------------------------------------------------------------------
1
PsiBlast_PDB
89.77
52%
27
- C5 -
5BOI
2
?
A:
[7-232]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
E
V
----
S
E
D
V
A
K
Q
V
A
R
S
--------
F
L
N
L
K
G
N
E
-
Q
I
H
I
V
K
S
G
K
D
A
D
Y
E
---------
V
Y
S
-
L
T
I
T
D
P
K
-
T
N
Q
E
T
Y
M
--
D
I
T
Q
-
K
G
G
Y
P
L
W
V
L
E
D
--------
R
D
I
-----
K
K
Q
N
I
S
L
N
D
A
M
N
K
---
A
T
K
F
L
K
D
-
H
----
R
F
E
S
----
L
V
------
M
A
E
S
----------
A
-
Q
--
Y
D
N
M
G
V
F
T
F
V
E
Q
T
-
E
S
G
V
R
I
Y
P
--------------
D
S
-------
V
K
M
K
M
-
S
L
E
D
G
S
V
I
G
----
F
S
A
K
D
F
L
L
K
H
R
------
T
------
R
D
I
P
K
P
K
I
S
K
E
Q
A
K
T
K
L
N
S
N
V
------
K
----------
V
---
M
E
-
E
R
---
L
A
I
I
T
-
N
D
----
L
N
E
E
V
-----
L
C
Y
-----
E
-
F
L
-
G
T
I
---
K
----
N
-------
D
----
T
Y
R
I
F
I
N
A
D
T
---------
G
F
E
E
K
V
E
K
L
Q
N
--------------------------------------------------------------------------
13
HHSearch
87.89
53%
26
- C5 -
5BOI
2
?
A:
[7-232]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
E
V
----
S
E
D
V
A
K
Q
V
A
R
S
--------
F
L
N
-
L
K
G
N
E
Q
I
H
I
V
K
S
G
K
D
A
D
Y
E
---------
V
Y
S
-
L
T
I
T
D
P
K
-
T
N
Q
E
T
Y
M
--
D
I
T
Q
-
K
G
G
Y
P
L
W
V
L
E
D
--------
R
D
I
-----
K
K
Q
N
I
S
L
N
D
A
M
N
K
---
A
T
K
F
L
K
D
-
H
----
R
F
E
S
----
L
V
------
M
A
E
S
----------
A
-
Q
--
Y
D
N
M
G
V
F
T
F
V
E
-
Q
T
E
S
G
V
R
I
Y
P
--------------
D
S
-------
V
K
M
K
M
-
S
L
E
D
G
S
V
I
G
----
F
S
A
K
D
F
L
L
K
H
R
------
T
------
R
D
I
P
K
P
K
I
S
K
E
Q
A
K
T
K
L
N
S
N
V
------
K
----------
V
---
M
E
-
E
R
---
L
A
I
I
T
-
N
D
----
L
N
E
E
V
-----
L
C
Y
-----
E
-
F
L
-
G
T
I
---
K
----
N
-------
D
----
T
Y
R
I
F
I
N
A
D
T
---------
G
F
E
E
K
V
E
K
L
Q
N
--------------------------------------------------------------------------
38
Fugue
53.34
17%
46
* C4 *
5DIY
1
?
B:
[2-473]
----------EYF
R
Y
R
G
I
I
E
----------
G
F
Y
G
K
P
W
E
H
Q
E
R
L
D
M
F
E
F
M
Q
A
N
N
L
N
A
Y
I
Y
A
P
K
Q
-----------
D
L
Y
H
R
E
L
W
R
E
P
Y
K
E
E
Q
------
L
Q
L
F
K
E
L
I
E
K
A
G
S
C
G
I
N
F
T
F
A
I
S
P
G
L
S
L
V
Y
S
S
E
E
E
L
E
T
---
L
I
R
K
I
T
P
F
L
EMGVHSIGI
F
F
D
N
V
P
F
D
L
I
H
E
E
D
R
-
N
-
S
Y
-
S
N
L
--
A
E
A
Q
A
-----
D
F
L
T
R
V
L
Q
R
L
E
S
T
I
S
T
-----
P
Q
I
I
M
C
P
T
F
Y
-------------
C
N
D
P
-
N
L
E
Y
-
L
R
I
L
G
Q
R
L
P
K
N
I
D
V
F
W
T
G
P
N
V
C
-
S
H
E
I
T
------
T
S
H
M
---
Q
E
V
Q
K
----
S
L
Q
R
P
A
T
L
W
D
N
--------
Y
P
V
-
N
D
G
G
-
M
M
P
E
L
H
I
G
P
Y
D
H
R
D
PELHTHVVG
I
Y
A
-
N
P
M
A
L
P
E
A
S
K
L
P
L
Y
T
--
F
A
Q
Y
-
L
N
S
P
S
Q
Y
N
P
Q
D
--------
S
W
R
-----
Q
A
V
S
T
L
L
G
E
D
N
L
S
---
A
M
E
K
F
Y
Q
-
S
NTIS
C
L
E
P
-
E
E
P
A
Y
------
L
T
N
L
----------
F
-
K
--
K
V
Q
E
D
F
A
S
F
R
F
-
E
-
Q
G
L
R
T
L
R
E
--------------
E
I
-------
I
S
M
Q
T
-
T
Y
S
R
L
S
T
Q
D
SKFF
W
E
I
R
P
W
L
E
E
Y
K
------
L
------
W
T
D
Y
L
D
Q
A
M
I
T
F
S
N
L
F
A
R
E
S
L
------
Q
----------
K
---
A
L
-
Q
G
---
R
T
Y
L
R
-
E
V
----
L
K
D
A
V
DFRTR
V
C
G
-----
D
-
V
V
-
R
N
F
---
L
----
Q
-------
Q
----
V
L
R
S
T
V
S
I
E
L
---------
Q
A
E
G
K
E
W
T
A
L
P
P
G
I
V
R
---------------------------------------------------------------------
40
Fugue
50.68
16%
-21
* C3 *
4USR
2
?
A:
[1-357]
---------------
G
P
A
M
P
P
I
L
D
V
I
V
I
G
G
G
-----------
Q
A
A
L
T
T
A
Y
F
L
R
R
T
S
L
-------------------------
S
Y
L
L
L
D
E
Q
------
P
G
P
G
G
A
W
L
H
A
W
D
----------------
S
L
R
L
F
S
P
A
A
W
-----
S
S
I
A
G
W
P
---------
M
P
S
P
T
---
E
P
G
N
P
T
R
-
N
-
D
V
-
I
D
Y
L
R
R
Y
E
D
R
-----
Y
Q
F
P
-----
I
Q
R
P
V
R
V
D
T
V
T
R
L
D
D
L
W
R
V
Q
A
G
-------------
D
Q
Q
W
-
L
A
R
A
-
V
I
S
------------
A
T
G
T
W
S
K
P
F
I
P
P
Y
E
G
R
E
L
----
F
---
Q
G
A
Q
I
----
H
S
A
H
Y
R
T
P
------------
A
P
-
F
A
G
K
-
R
V
M
V
V
G
G
G
N
S
G
A
Q
V
---------
L
A
E
-
L
S
-------
S
V
S
E
T
L
--
W
I
T
Q
-
E
P
--
P
A
F
L
P
D
E
--------
V
--------
D
G
R
V
L
F
E
R
A
T
A
R
---
W
K
A
Q
Q
E
G
-
R
----
S
I
D
E
-
P
A
-
G
G
------
F
G
D
I
----------
V
-
M
--
V
P
P
V
R
E
A
R
E
R
G
-
V
-
L
V
A
E
R
P
F
A
--------------
R
F
-------
T
E
T
G
V
-
E
W
A
D
G
R
R
E
N
----
L
D
A
V
I
W
C
S
G
F
R
------
P
AL----
D
H
L
R
E
L
G
V
V
E
A
D
G
K
V
Q
V
E
D
T
R
------
V
----------
V
---
K
Q
-
P
N
---
L
W
L
V
G
-------------------
Y
-----
G
-
D
W
-
T
G
M
---
A
----
S
-------
A
----
T
L
I
G
V
T
R
T
A
R
---------
S
T
A
D
Q
V
V
Q
A
L
T
A
T
P
-----------------------------------------------------------------------
42
Fugue
49.02
16%
37
- C4 -
5DSE
-
TTC7B_HUMAN
A:
[140-843]
-------V
I
A
E
A
Y
A
T
K
G
L
C
L
E
D
V
I
T
C
Y
E
K
A
G
D
I
A
L
L
-
Y
L
Q
E
I
E
R
V
L
G
F
F
L
E
T
G
L
Q
R
A
H
V
L
Y
F
K
N
GN
L
T
R
G
V
G
R
F
R
E
L
L
R
A
V
E
T
R
T
T
Q
N
L
R
------
M
T
I
A
R
Q
L
A
E
I
L
L
R
G
M
-
C
E
Q
S
Y
W
N
P
-
L
E
D
P
F
C
P
Q
E
N
T
E
E
A
L
L
L
L
L
I
S
E
S
M
A
---------
N
R
S
V
V
Y
D
L
L
T
I
A
L
G
R
-
R
G
Q
Y
-
E
M
L
S
E
C
L
E
R
A
M
K
F
AF
E
E
F
H
L
W
Y
Q
F
A
L
S
L
M
A
A
G
K
S
A
R
A
V
K
V
L
K
E
C
I
R
-------------
L
K
P
D
-
D
A
T
I
P
L
L
A
A
-
K
L
C
M
G
S
L
H
W
L
E
E
A
E
K
F
A
K
T
V
V
T
S
E
F
K
A
K
G
Y
L
A
L
G
L
T
Y
S
L
Q
A
----
T
D
A
S
L
R
G
M
Q
E
V
--------
L
Q
R
-
K
A
L
L
-
A
F
Q
R
A
H
S
L
S
P
T
----------------------
D
-
H
Q
A
A
F
Y
L
A
L
Q
L
A
I
-
S
R
Q
I
P
E
A
L
G
Y
V
--------
R
Q
A
-----
L
Q
L
Q
G
D
-
D
A
N
S
L
H
---
L
L
A
L
L
L
S
A
Q
----
K
H
Y
H
-
D
A
-
L
N
------
I
I
D
M
----------
A
-
L
--
S
E
----------
Y
-
P
E
N
F
I
L
L
F
--------------
S
K
-------
V
K
L
Q
S
-
L
C
R
G
P
D
E
A
L
----
L
T
C
K
H
M
L
Q
I
W
K
------
S
C
YLHP
W
M
T
L
A
Q
I
W
L
H
A
A
E
V
Y
I
G
I
G
K
P
A
------
E
----------
A
---
T
A
C
T
Q
---
E
A
A
N
L
-
F
P
----
M
S
H
N
V
-----
L
Y
M
R
G
Q
I
A
E
-
L
R
-
G
S
----
M
----
D
-------
E
----
A
R
R
W
Y
E
E
A
L
A
---------
I
S
P
T
H
V
K
S
M
Q
R
L
A
L
I
L
H
Q
L
GR
Y
S
L
A
E
K
I
L
R
D
A
V
Q
V
NSTA
H
E
V
W
N
G
L
G
E
V
L
Q
A
Q
GN
D
A
A
A
T
E
C
F
L
T
A
L
E
L
E
A
S
SPAVPFTIIPRVL
22
HHSearch
45.18
11%
-50
- C5 -
2FGT
-
YYCH_BACSU
A:
[272-388]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
--
D
V
N
L
-
S
Q
R
Q
-
V
Q
F
Q
Q
----------
L
V
-----
Q
S
T
S
Y
Q
T
G
E
L
I
K
K
---
S
Q
K
Y
L
E
D
-
T
----
G
S
W
T
-
D
H
-
Y
Q
------
F
F
N
I
----------
N
-
D
-----
S
Q
Q
L
S
F
Y
I
-
F
-
M
D
Q
I
P
V
I
N
--------------
S
T
AKPFGAT
S
A
I
T
V
-
Q
W
A
N
D
D
I
L
S
----
Y
K
R
P
N
Y
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
45.03
11%
-83
- C- -
4K61
-
?
A:
[26-149]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
---
V
Q
A
A
L
K
K
-
M
-----
Y
P
T
----
A
D
------
G
V
A
W
----------
S
-
H
--
D
E
S
Y
Y
V
A
D
F
L
M
----
N
G
-------------------
F
D
-------
T
K
V
W
F
-
D
G
-
Q
A
Q
W
V
M
----
Q
Q
T
D
W
E
---
T
-------
M
------
D
E
V
P
P
A
V
Y
N
A
F
-
A
A
S
E
Y
S
-
G
G
------
M
----------
V
---
Q
N
-
V
T
---
W
--
V
Q
-
F
------
P
K
W
Q
-----
S
I
V
-----
A
-
V
E
-
V
G
M
AN-
L
----
Q
-------
T
----
K
Y
Q
I
L
F
T
P
T
----------
G
E
I
I
R
A
R
N
V
T
Y
--------------------------------------------------------------------------
32
HHSearch
44.92
10%
-59
- C5 -
4IPB
2
?
A:
[6-133]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
---
V
Q
S
T
F
K
K
-
M
-----
Y
P
K
----
A
N
------
G
V
A
W
----------
S
-
Q
--
D
D
G
Y
Y
C
A
N
F
A
M
----
N
G
F
-------------------
T
-------
K
N
V
W
F
-
N
V
-
R
G
Q
W
V
M
----
T
L
T
D
L
-----
V
------
S
L-----
D
R
L
T
P
T
V
Y
N
A
F
V
-
S
G
P
Y
A
-
N
W
------
V
----------
V
---
D
N
-
V
T
-----
M
V
E
-------
F
P
K
W
Q
-----
A
I
I
-----
V
-
I
K
-
V
G
Q
---
D
----
N
VD-----
I
----
K
Y
Q
L
F
Y
T
P
-
Q
---------
G
I
L
L
K
T
R
N
V
S
D
M
Y
D
I
----------------------------------------------------------------------
33
HHSearch
42.61
10%
-96
- C- -
4FR9
-
?
A:
[34-157]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
A
---
I
Q
D
A
L
---
L
-----
Y
P
N
----
A
T
------
A
I
-
W
----------
E
-
Q
---
G
V
Y
Y
V
A
D
C
Q
A
----
D
G
-------------------
R
E
--------
E
V
W
F
-
D
A
-
N
A
N
W
L
M
----
T
E
T
E
L
N
----
S
------
I
------
N
N
L
P
P
A
V
L
T
A
F
M
-
E
S
S
Y
N
-
N
W
------
V
----------
V
---
D
D
-
V
V
---
I
--
L
E
-
Y
-----
P
N
E
P
S
-----
T
E
F
-----
V
-
V
T
-
V
E
Q
---
G
------------------
V
D
L
Y
F
S
E
-
G
---------
G
G
L
L
H
E
-
D
V
T
N
--------------------------------------------------------------------------
39
Fugue
41.94
13%
62
- C3 -
3GBT
-
?
A:
[0-491]
S
L
K
Y
I
I
G
M
D
VGTT
A
T
K
G
V
L
Y
D
I
N
G
-
K
A
V
A
S
V
S
K
G
Y
P
-
L
I
Q
T
K
V
G
Q
A
E
E
D
P
K
L
I
F
D
A
V
Q
E
I
I
F
D
----------
L
T
Q
K
I
D
G
K
I
A
A
I
S
W
S
S
Q
M
-----
H
S
L
--
I
G
L
G
---------
S
D
D
E
L
L
-
T
N
S
I
T
W
A
D
N
C
A
K
S
---
I
V
Q
D
A
K
N
R
G
---------
F
A
Q
Q
I
Y
R
K
T
-----
G
M
P
M
H
P
M
A
P
I
Y
K
L
L
W
L
K
-----
N
K
K
T
E
V
F
S
Q
A
Q
K
W
I
G
I
K
E
Y
I
I
F
R
L
T
G
K
L
V
T
D
T
T
M
A
A
G
T
GILNLK
T
L
T
W
-
D
Q
E
L
-
L
D
I
L
-
K
I
K
K
E
Q
L
P
K
I
A
Q
P
T
K
V
I
F
P
I
K
T
E
Y
V
K
K
L
G
I
D
-----
S
D
T
K
I
I
LGA
S
D
G
Y
L
S
T
I
G
V
N
AIDSD
H
C
A
L
N
V
-
G
T
S
G
-
A
I
R
T
I
V
D
Q
P
K
I
D
P
S
---------
A
S
Y
-
F
C
Y
P
A
D
K
-
T
H
Y
L
L
G
G
--
P
V
N
N
-
G
G
I
V
F
N
W
A
R
Q
T
LFDADET
P
Q
D
F
-----
L
D
V
A
Q
T
A
P
A
G
S
R
N
---
L
I
F
L
P
Y
L
-
G
----
G
E
R
A
----
P
I
------
W
D
A
N
----------
A
-
R
--
G
S
F
V
G
L
------------------------------
T
R
M------
H
Q
K
P
E
M
A
R
A
V
I
E
G
I
I
----
F
N
L
Y
D
A
A
S
N
L
I
------
K
NT----
K
K
P
V
A
I
N
A
T
G
G
F
L
K
S
D
F
V
R
Q
L
------
C
----------
A
---
N
I
-
F
N
---
V
P
I
V
T
M
K
E
----
Q
Q
-
S
G
-----
T
L
A
-----
A
M
F
L
-
A
R
Q
---
A
----
L
-------
G
----
L
N
Q
D
L
S
E
I
G
Q
FAQAD
K
V
Y
F
P
N
P
K
E
A
A
T
Y
Q
K
L
F
P
L
Y
C
E
I
R
N
A
L
A
ASYGKFS------------------------------------------------------
14
HHSearch
41.42
12%
12
- C5 -
3NQZ
-
?
A:
[5-175]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
N
Q
--------
Q
P
T
-----
I
N
N
M
V
Q
S
N
--------
S
V
S
P
N
Q
L
-
I
----
G
L
S
V
G
N
E
-
L
V
------
V
L
K
E
----------
F
T
S
--
N
N
G
E
V
T
R
R
Y
Q
Q
-
T
-
Y
Q
G
I
P
V
I
G
--------------
D
T
-------
V
S
L
T
F
-
N
--
N
G
M
L
K
K
----
A
H
G
A
A
V
Y
N
I
D
E
------
D
------
L
S
D
V
S
A
K
L
T
K
K
D
A
I
L
K
G
S
K
T
G
------
I
A
A
K
S
VGLKKH
N
---
E
Q
-
S
R
---
L
A
I
W
V
-
D
D
----
Q
N
K
A
H
-----
L
V
Y
-----
E
-
V
S
-
Y
V
T
Y
G
K
S
----
P
-------
S
----
R
P
Y
L
I
I
D
A
N
T
---------
G
E
V
L
L
S
Y
------------------------------------------------------------------------------
21
HHSearch
41.40
16%
46
* C5 *
5BOI
2
?
A:
[9-152]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
E
D
V
A
K
Q
V
---
A
R
S
F
L
N
L
-
K
----
G
N
E
Q
----
I
H
------
I
V
K
S
----------
G
-
K
DA
D
Y
E
V
Y
S
L
T
I
T
D
-
P
-
K
-----
T
N
--------------
Q
E
-------
T
Y
M
D
I
-
T
Q
K
G
G
Y
P
L
W
----
V
L
E
D
R
D
-------------------
I
-
K
K
Q
N
I
S
L
N
D
A
M
N
K
A
T
K
F
L
------
K
----------
D
H
RF
E
S
-
L
V
---
M
A
E
S
A
-
Q
Y
----
D
N
M
G
V
-----
F
T
F
-----
V
-
E
Q
T
E
S
G
VRI
Y
----
P
-------
D
----
S
V
K
M
K
M
S
L
E
D
---------
G
S
V
I
G
F
S
A
K
----------------------------------------------------------------------------
43
Fugue
40.89
19%
52
- C3 -
5EZ7
3
?
A:
[2-392]
-------------
M
P
Q
A
L
S
T
---
D
I
L
I
V
G
G
G
------------
I
A
G
L
W
L
N
A
R
L
R
R
A
G
Y
A
-
T
V
L
----------
V
E
S
--
A
S
L
G
G
G
Q
S
V
K
S
Q
GIIHGG
T
G
A
S
E
A
I
A
D
M
P
R
R
W
R
-
A
C
L
G
S
D
G
E
-
L
D
L
-----
R
G
V
R
L
---
L
S
E
A
H
Y
L
W
S
---------
P
V
E
Q
A
K
G
E
D
L
P
P
A
L
R
-
D
-
K
------------------
G
F
K
G
K
A
Y
R
L
T
E
I
V
F
-------
D
V
P
D
L
I
R
R
L
-------------
A
E
L
A
-
G
D
S
L
-
L
A
G
E
-
R
I
E
P
L
R
E
G
R
E
L
A
G
L
C
V
D
--------------------
G
R
E
I
----
R
A
Q
---------------------------
R
V
V
L
S
A
G
A
G
N
E
A
---------
L
L
R
E
L
G
L
E
Q
P
A
M
Q
R
R
P
L
H
M
--
V
M
V
K
A
A
T
L
K
P
L
Y
A
H
C
L
--------
G
A
G
-----
P
K
P
R
I
T
V
T
T
H
P
T
R
DG
Q
S
V
W
Y
L
G
G
-
D
----
I
A
E
T
-
D
G
-
V
A
------
R
D
E
A
----------
A
-
Q
--
I
A
E
---------
A
-
R
R
E
L
A
K
L
L
--------------
P
W
-------
I
D
L
G
Q
-
A
----------------
Q
W
A
T
L
R
V
------
D
------
R
A
E
P
------
A
Q
S
N
L
L
R
P
D
N
A
------
F
----------
L
---
A
E
-
Q
G
R
L
L
V
G
W
P
T
-
K
L
----
A
L
A
P
D
-----
F
A
D
-----
R
-
V
C
-
A
R
L
---
E
----
E
-------
D
----
G
I
R
---
P
S
E
H
---------
A
A
L
P
Q
L
P
R
P
P
L
A
E
P
A
W
E
V
A
F
A----------------------------------------------------------------
18
HHSearch
40.84
13%
-9
- C5 -
2O3O
1
YYCI_BACSU
A:
[83-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
L
S
K
K
D
I
E
D
D
---
A
Q
A
L
V
S
S
-
K
----
I
Q
D
G
-
E
K
-
Y
K
------
L
W
------------
K
-
V
--
D
K
S
K
K
E
I
I
F
F
Q
-
T
-
Y
E
G
H
Y
I
Y
Q
KTDNPSNMI-----
G
Q
-------
V
V
L
H
L
-
N
G
-
K
N
E
V
V
S
----
Y
D
Q
T
T
L
E
T
--
F
------
K
------
Q
I
Q
K
E
S
L
I
T
E
M
D
A
V
E
L
L
Y
Y
Q
N
QLKEYS
T
----------
V
---
K
S
-
C
K
---
F
G
Y
V
A
-
Q
Y
PLTS
T
Q
V
L
A
-----
P
V
W
-----
R
-
I
T
-
V
E
Y
---
E
K-----------
E
KKT
V
Q
E
Y
F
T
V
N
A
L
E
---------
S
T
I
L
D
T
-------------------------------------------------------------------------------
46
Fugue
40.64
16%
14
- C2 -
4QTS
-
CSM4_METJA
A:
[1-369]
-----------------
M
K
M
V
V
L
K
P
K
I
N
S
K
F
H
F
K
I
----
F
H
S
N
S
L
F
S
A
I
V
N
N
Y
I
K
L
Y
G
-------------------
R
E
D
L
E
K
N
I
E
K
I
K
N
------
I
R
L
S
S
L
L
Y
K
I
---------------
K
N
I
Y
L
I
P
K
P
E
H
P
E
---
F
Y
P
K
----------------------
D
I
K
K
I
Q
F
-
F
-
S
I
-
K
A
Y
K
E
L
L
D
N
E
-----
L
D
W
K
N
K
I
K
H
I
V
D
Y
---------------------------------
Q
T
I
N
K
S
I
-
V
I
S
E
-
K
E
I
E
E
I
K
R
I
F
G
I
-------------
K
A
E
K
L
K
H
A
---
K
I
S
L
I
----
S
K
H
L
E
Q
K
V
A
D
K
-----------------------------
G
Q
---------
L
Y
N
-
I
E
F
I
K
L
N
-
E
N
V
E
F
Y
F
--
L
I
D
Y
-
N
---------------------------
N
E
D
K
E
F
I
K
K
L
E
A
---
S
I
K
L
I
E
D
-
E
----
G
L
G
G
-
A
---------------------------------
G
F
F
E
K
V
E
-
I
-
V
D
L
P
E
D
F
N
--------------
E
I
-------
L
D
E
N
S
-
K
Y
N
N
L
E
Y
K
M
----
L
L
G
V
G
I
P
N
K
D
D
------
I
------
K
N
I
E
Y
Y
K
L
I
E
I
G
G
-
Y
I
Y
S
L
E
C
------
L
----------
T
---
K
P
-
K
R
---
N
I
L
A
L
-
T
E
---------------------------
G
S
I
---
V
----
K
-------
N
----
D
F
I
G
D
V
K
------------------
D
V
Y
T
H
G
K
P
I
L
L
P
F
N
P----------------------------------------------------------------
16
HHSearch
40.47
13%
29
- C5 -
5COZ
1
?
A:
[139-357]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
K
F
G
T
Y
Y
S
P
F
N
D
--------
K
D
K
FRTDK
Q
L
M
F
M
S
A
E
E
A
E
E
L
---
A
V
K
T
A
K
E
-
L
----
E
I
N
V
----
C
E
K
N
E
L
Y
V
L
D
D
K
NTLIFPEDDT
D
-
K
--
Q
N
D
T
Y
V
F
F
M
F
P
-
D
-
V
Y
G
I
P
Y
S
R
CPENEALTGYANQE
N
H
-------
L
V
I
A
M
-
D
E
-
K
G
-
I
S
F
----
L
D
I
P
P
L
Y
D
-
W
V
------
E
------
T
T
E
T
G
E
I
L
H
P
S
S
I
L
S
K
E
V
D
K
L
------
K
K
Y
VTS
G
D
I
E
-
V
---
S
E
-
I
S
---
L
E
Y
M
L
-
F
A
D
K
NE
T
Y
D
I
K
-----
P
V
W
-----
V
-
V
Y
-
Y
Y
Q
---
N
QLVT
G
EN
S
Y
T
Q
K
M
----
A
L
Y
D
V
Y
D
A
Y
T
---------
G
E
E
Y
R
I
-------------------------------------------------------------------------------
20
HHSearch
40.03
17%
28
- C5 -
4EXR
2
?
A:
[28-171]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
F
K
V
P
Y
T
D
A
I
N
I
---
F
K
D
K
Y
K
D
-
A
----
D
I
V
D
----
L
S
------
L
E
R
-----------
D
-
L
--
N
K
F
V
Y
T
V
E
G
V
D
----
D
N
-------------------
N
E
-------
Y
K
M
K
I
-
D
A
N
T
K
D
V
L
E
----
D
K
T
E
K
L
D
S
E
D
L
NGVARK
E
------
K
L
D
L
N
D
I
M
T
P
Q
Q
A
M
E
I
A
L
K
E
Q
------
N
GI--------
V
---
K
E
-
W
S
---
L
--
D
--------
K
D
L
D
V
-----
T
F
Y
-----
K
-
I
R
-
I
D
K
---
D
----
K
-------
N
----
E
Y
D
I
K
V
D
S
K
K
---------
G
T
V
L
K
V
E
------------------------------------------------------------------------------
41
Fugue
39.49
14%
22
- C3 -
1UMG
6
?
A:
[1-362]
----------------
K
T
T
I
S
V
I
K
A
D
I
G
S
L
A
------
G
H
H
I
V
H
P
D
T
M
A
A
A
N
K
V
L
A
S
A
K
E
Q
G
I
I
----------
L
D
Y
Y
I
T
H
V
G
D
D
L
Q
L
I
M
T
------
H
T
R
G
E
L
D
T
K
V
H
E
T
A
W
-
N
A
F
K
E
A
A
K
-
V
A
K
D
L
G
L
Y
A
A
G
Q
D
---
L
L
S
D
------------------------------------------
S
F
S
-----
G
N
V
R
G
L
G
P
G
V
A
E
M
E
I
E
E
--
R
A
S
E
P
I
A
I
F
M
A
D
KT-----------
E
P
G
A
-
Y
N
L
P
-
L
Y
K
M
-
F
A
D
P
F
N
T
P
G
L
V
I
D
P
T
M
H
G
G
F
K
F
E
V
L
D
V
Y
Q
G
E
A
V
---
M
L
S
------
A
P
Q
E
I
Y
D
L
L
A
L
--------
I
G
T
-
P
A
R
Y
-
V
I
R
R
V
Y
R
-
N
E
D
N
L
L
---------
A
A
V
-
V
S
I
E
R
L
N
-
L
I
Y
V
G
K
D
--
D
--------
P
V
M
I
V
R
L
--------
Q
------------
H
G
L
P
A
L
G
E
---
A
L
E
A
F
A
F
-
P
----
H
L
V
P
-
G
W
-
M
R
------
G
S
H
Y
----------
G
-
P
--
L
M
P
V
S
Q
R
D
A
K
A
-
T
-
R
F
--
D
G
P
P
--------------
R
L
-------
L
G
L
G
F
-
N
V
K
N
G
R
L
V
G
------
P
T
D
L
F
D
D
P
A
------
F
------
D
E
T
R
R
L
A
N
I
V
A
D
Y
M
R
R
H
G
P
F
M
------
P
----------
H
---
R
-------------------
L
E
P
T
E
-----
M
E
Y
-------------------------------------------
T
---------
T
L
P
L
I
L
E
K
L
K
D
R
F
K
K
----------------------------------------------------------------------
2
PsiBlast_PDB
38.33
25%
-35
- C6 -
1C5D
-
IGG2B_RAT
H:
[14-106]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
S
Q
T
L
-
S
L
T
C
T
V
S
G
F
P
L
T
T
N
---------
G
V
S
-
W
-
V
R
Q
P
P
-
G
K
G
L
E
W
I
--
A
A
I
S
-
S
G
G
S
P
Y
Y
---
N
--------
S
A
L
-----
K
S
-
R
L
S
I
N
R
D
T
S
K
---
S
Q
V
F
L
K
M
-
N
----
S
L
Q
T
-
E
D
-
T
A
------
I
Y
F
C
----------
T
-
R
--
E
D
G
W
N
Y
F
D
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------