@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu27260: (2016-07-12 )
MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIKDRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREKQQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGPEMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHKTEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEEAKKASAGTNIVTVFPDSSDRYISKQIYEGGI
Atome Classification :
(70 SA)
.........10........--20..----..-.-------..--.--30........40........50........60..--.-.--.-...70........80........90........100.......110.....---..---120...---....130....-...140.-......150..-.....160.......170.......180.......190-..--.-.....200..-----...-.------.210-.------......220.......230.......240.......250.......260.......270...-...-.280-..-...-....290.......300.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
V
I
T
D
I
T
E
L
IGNT
P
L
L
R
L
--KNFD----VP-E-------
G
V
--
A
--
V
Y
A
K
L
E
M
MNPGG
S
I
K
D
R
L
G
D
M
L
I
R
D
ALDSGKVKP--G-
G
--
V
-
I
I
E
ATAGNT
G
I
G
L
A
L
S
A
RKYG
L
K
A
I
F
CV
P
E
H
F
S
R
E
K
Q
Q
I
M
Q
A
L
G
A
S
IIHTP---RQ---D
G
M
Q
G
A
---
I
Q
K
A
I
Q
L
E
T
EI-EN
S
Y
C
V
L
-
Q
FKNRV
N
P
S
T
Y
-
Y
K
TL
G
P
E
M
W
E
A
LDGN
I
H
T
F
V
AGAGSGGT
F
A
G
T
A
S
F
L
K--EK--N-PA
V
K
T
V
I
V
E
P
-----
V
G
S
-I------LNGG-E------PHAHKTEGI
G
M
E
F
I
P
D
Y
M
D
KSHFD
E
I
Y
T
VTD
E
N
A
F
R
L
V
K
E
A
AEKE
G
L
L
I
GSSS
G
A
A
L
Y
A
A
L
E
-
E
A
K
-KA---SA-GT
N
-
I
V
T
VFPDSSD
R
Y
I
S
K
Q
I
YEGGI
1
PsiBlast_PDB
80.12
53%
24
- C2 -
4R2V
-
CYSM_HELPY
A:
[1-305]
M
M
I
I
T
T
M
Q
D
A
I
G
R
T
P
V
F
K
F
T
N
K
D
Y
P
----
I
P
-
L
-------
N
S
--
A
--
I
Y
A
K
L
E
H
L
N
P
G
G
S
V
K
D
R
L
G
Q
Y
L
I
E
E
G
F
K
T
G
K
I
T
S
--
K
-
T
--
T
-
I
I
E
P
T
A
G
N
T
G
I
A
L
A
L
V
A
I
K
H
H
L
K
T
I
F
V
V
P
E
K
F
S
T
E
K
Q
Q
I
M
R
A
L
G
A
L
V
I
N
T
P
---
T
S
---
E
G
I
S
G
A
---
I
K
K
S
K
E
L
A
E
S
I
-
P
D
S
Y
L
P
L
-
Q
F
E
N
P
D
N
P
A
A
Y
-
Y
H
T
L
A
P
E
I
V
Q
E
L
G
T
N
L
T
S
F
V
A
G
I
G
S
G
G
T
F
A
G
T
A
R
Y
L
K
--
E
R
--
I
-
P
A
I
R
L
I
G
V
E
P
-----
E
G
S
-
I
------
L
N
G
G
-
E
------
P
G
P
H
E
I
E
G
I
G
V
E
F
I
P
P
F
F
E
N
L
D
I
D
G
F
E
T
I
S
D
E
E
G
F
S
Y
T
R
K
L
A
K
K
N
G
L
L
V
G
S
S
S
G
A
A
F
V
A
A
L
K
-
E
A
Q
-
R
L
---
P
E
-
G
S
Q
-
V
L
T
I
F
P
D
V
A
D
R
Y
L
S
K
G
I
Y
----
21
PsiBlast_CBE
79.23
53%
32
- C2 -
5HBG
1
CYSM_HELPY
B:
[1-305]
M
M
I
I
T
T
M
Q
D
A
I
G
R
T
P
V
F
K
F
TN
K
D
Y
P
----
I
P
-
L
-------
N
S
--
A
--
I
Y
A
K
L
E
H
L
N
P
G
G
S
V
K
D
R
L
G
Q
Y
L
I
G
E
G
F
K
T
G
K
I
T
S
--
K
-
T
--
T
-
I
I
E
P
T
A
G
N
T
G
I
A
L
A
L
V
A
I
K
H
H
L
K
T
I
F
V
V
P
E
K
F
S
T
E
K
Q
Q
I
M
R
A
L
G
A
L
V
I
N
T
P
---
T
S
---
E
G
I
S
G
A
---
I
K
K
S
K
E
L
A
E
S
I
-
P
D
S
Y
L
P
L
-
Q
F
E
N
P
D
N
P
A
A
Y
-
Y
H
T
L
A
P
E
I
V
Q
E
L
G
T
N
L
T
S
F
V
A
G
I
G
S
G
G
T
F
A
G
T
A
R
Y
L
K
--
E
R
--
I
-
P
A
I
R
L
I
G
V
E
P
-----
E
G
S
-
I
------
L
N
G
G
-
E
------
P
G
P
H
E
I
E
G
I
G
V
E
F
I
P
P
F
F
E
N
L
D
I
D
G
F
E
T
I
S
D
E
E
G
F
S
Y
T
R
K
L
A
K
K
N
G
L
L
V
G
S
S
S
G
A
A
F
V
A
A
L
K
-
E
A
Q
-
R
L
---
P
E
-
G
S
Q
-
V
L
T
I
F
P
D
V
A
D
R
Y
L
S
K
G
I
Y
----
4
PsiBlast_PDB
78.90
41%
-52
- C2 -
2Q3D
2
CYSK_MYCTU
A:
[4-308]
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
--
R
R
V
T
----
D
G
-
A
-------
V
A
--
D
--
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
--
I
-
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
G
M
S
G
A
---
I
A
K
A
E
E
L
A
K
T
D
-
Q
R
Y
F
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
--
K
-
P
S
A
R
F
V
A
V
E
P
-----
A
A
S
P
V
------
L
S
G
G
-
Q
------
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
-
V
A
R
-
R
P
E--
N
A
-
G
K
L
-
I
V
V
V
L
P
D
F
G
E
R
Y
L
S
T
P
L
F
----
2
PsiBlast_PDB
78.88
53%
24
- C2 -
5HBG
-
CYSM_HELPY
A:
[1-305]
M
M
I
I
T
T
M
Q
D
A
I
G
R
T
P
V
F
K
F
T
N
K
D
Y
P
----
I
P
-
L
-------
N
S
--
A
--
I
Y
A
K
L
E
H
L
N
P
G
G
S
V
K
D
R
L
G
Q
Y
L
I
G
E
G
F
K
T
G
K
I
T
S
--
K
-
T
--
T
-
I
I
E
P
T
A
G
N
T
G
I
A
L
A
L
V
A
I
K
H
H
L
K
T
I
F
V
V
P
E
K
F
S
T
E
K
Q
Q
I
M
R
A
L
G
A
L
V
I
N
T
P
---
T
S
---
E
G
I
S
G
A
---
I
K
K
S
K
E
L
A
E
S
I
-
P
D
S
Y
L
P
L
-
Q
F
E
N
P
D
N
P
A
A
Y
-
Y
H
T
L
A
P
E
I
V
Q
E
L
G
T
N
L
T
S
F
V
A
G
I
G
S
G
G
T
F
A
G
T
A
R
Y
L
K
--
E
R
--
I
-
P
A
I
R
L
I
G
V
E
P
-----
E
G
S
-
I
------
L
N
G
G
-
E
------
P
G
P
H
E
I
E
G
I
G
V
E
F
I
P
P
F
F
E
N
L
D
I
D
G
F
E
T
I
S
D
E
E
G
F
S
Y
T
R
K
L
A
K
K
N
G
L
L
V
G
S
S
S
G
A
A
F
V
A
A
L
K
-
E
A
Q
-
R
L
---
P
E
-
G
S
Q
-
V
L
T
I
F
P
D
V
A
D
R
Y
L
S
K
G
I
Y
----
22
PsiBlast_CBE
78.80
40%
-103
- C2 -
4I1Y
2
?
B:
[5-301]
M
T
I
A
E
N
I
A
Q
L
I
G
G
T
P
L
V
R
L
--
R
R
V
T
----
D
G
-
A
-------
A
A
--
D
--
V
V
A
K
L
E
S
F
N
P
A
G
S
I
K
D
R
I
G
V
A
M
I
D
A
A
E
K
A
G
L
I
K
P
--
D
-
T
--
I
-
I
L
E
P
T
--
N
T
G
I
A
L
A
M
V
S
A
A
R
G
Y
K
C
V
L
T
M
P
D
T
M
S
I
E
R
R
M
L
L
R
A
Y
G
A
E
L
V
L
T
P
---
G
A
---
E
G
M
A
G
A
---
I
A
K
A
E
E
L
A
K
T
D
-
D
R
Y
F
I
P
Q
-------
N
P
A
V
H
-
A
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
F
V
S
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
Q
R
--
R
-
P
S
A
Q
F
V
A
V
E
P
-----
A
---------------------------------------
L
D
L
A
L
V
D
E
V
I
T
V
G
N
D
D
A
L
E
L
A
R
R
M
A
T
E
E
G
L
L
F
G
I
S
S
G
A
A
V
W
A
A
R
E
-
L
A
H
-
R
P
E--
N
A
-
G
K
L
-
I
V
V
V
L
P
D
F
G
E
------------
3
PsiBlast_PDB
78.44
41%
-56
- C2 -
3ZEI
4
CYSK_MYCTU
A:
[1-300]
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
--
R
R
V
T
----
D
G
-
A
-------
V
A
--
D
--
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
--
I
-
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
G
M
S
G
A
---
I
A
K
A
E
E
L
A
K
T
D
-
Q
R
Y
F
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
--
K
-
P
S
A
R
F
V
A
V
E
P
-----
A
A
S
P
V
------
L
S
G
G
-
Q
------
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
-
V
A
R
-
R
P
E--
N
A
-
G
K
L
-
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------
11
PsiBlast_PDB
78.37
40%
-98
- C2 -
4I1Y
2
?
A:
[5-301]
M
T
I
A
E
N
I
A
Q
L
I
G
G
T
P
L
V
R
L
--
R
R
V
T
----
D
G
-
A
-------
A
A
--
D
--
V
V
A
K
L
E
S
F
N
P
A
G
S
I
K
D
R
I
G
V
A
M
I
D
A
A
E
K
A
G
L
I
K
P
--
D
-
T
--
I
-
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
S
A
A
R
G
Y
K
C
V
L
T
M
P
D
T
M
S
I
E
R
R
M
L
L
R
A
Y
G
A
E
L
V
L
T
P
---
G
A
---
E
G
M
A
G
A
---
I
A
K
A
E
E
L
A
K
T
D
-
D
R
Y
F
I
P
Q
-------
N
P
A
V
H
-
A
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
F
V
S
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
Q
R
--
R
-
P
S
A
Q
F
V
A
V
E
P
----------------------------------------------
D
L
A
L
V
D
E
V
I
T
V
G
N
D
D
A
L
E
L
A
R
R
M
A
T
E
E
G
L
L
F
G
I
S
S
G
A
A
V
W
A
A
R
E
-
L
A
H
-
R
P
E--
N
A
-
G
K
L
-
I
V
V
V
L
P
D
F
G
E
------------
5
PsiBlast_PDB
77.77
40%
-53
- C2 -
2Q3B
5
CYSK_MYCTU
A:
[4-303]
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
--
R
R
V
T
----
D
G
-
A
-------
V
A
--
D
--
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
--
I
-
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
G
M
S
G
A
---
I
A
K
A
E
E
L
A
K
T
D
-
Q
R
Y
F
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
--
K
-
P
S
A
R
F
V
A
V
E
P
-----
A
A
S
P
V
------
L
S
G
G
-
Q
------
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
-
V
A
R
-
R
P
E--
N
A
-
G
K
L
-
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------
121
HHSearch
77.70
42%
-28
- C2 -
1O58
2
?
A:
[14-303]
------
M
E
R
L
I
G
S
T
P
I
V
R
L
--
D
S
I
----------------
D
S
--
R
--
I
F
L
K
L
E
K
N
N
P
G
G
S
V
K
D
R
P
A
L
F
M
I
L
D
A
E
K
R
G
L
L
K
N
-------
G
-
I
V
E
P
T
S
G
N
M
G
I
A
I
A
M
I
G
A
K
R
G
H
R
V
I
L
T
M
P
E
T
M
S
V
E
R
R
K
V
L
K
M
L
G
A
E
L
V
L
T
P
---
G
E
---
L
G
M
K
G
A
---
V
E
K
A
L
E
I
S
R
E
--
T
G
A
H
M
L
N
-
Q
F
E
N
P
Y
N
V
Y
S
H
-
Q
F
T
T
G
P
E
I
L
K
Q
M
D
Y
Q
I
D
A
F
V
A
G
V
G
T
G
G
T
I
S
G
V
G
R
V
L
K
--
G
F
--
F
G
N
G
V
K
I
V
A
V
E
P
-----
A
K
S
P
V
------
L
S
G
G
-
Q
------
P
G
K
H
A
I
Q
G
I
G
A
G
F
V
P
K
I
L
D
R
S
V
I
D
E
V
I
T
V
E
D
E
E
A
Y
E
M
A
R
Y
L
A
K
K
E
G
L
L
V
G
I
S
S
G
A
N
V
A
A
A
L
K
-
V
A
Q
-
K
L
---
G
P
-
D
A
R
-
V
V
T
V
A
P
D
H
A
E
R
Y
L
S
I
L
------
111
HHSearch
77.32
53%
27
- C2 -
4R2V
-
CYSM_HELPY
A:
[1-306]
M
M
I
I
T
T
M
Q
D
A
I
G
R
T
P
V
F
K
F
--
T
N
K
-----
D
Y
P
I
PL-----
N
S
--
A
--
I
Y
A
K
L
E
H
L
N
P
G
G
S
V
K
D
R
L
G
Q
Y
L
I
E
E
G
F
K
T
G
K
I
T
S
--
K
-
T
--
T
-
I
I
E
P
T
A
G
N
T
G
I
A
L
A
L
V
A
I
K
H
H
L
K
T
I
F
V
V
P
E
K
F
S
T
E
K
Q
Q
I
M
R
A
L
G
A
L
V
I
N
T
P
---
T
S
---
E
G
I
S
G
A
---
I
K
K
S
K
E
L
A
E
S
I
-
P
D
S
Y
L
P
L
-
Q
F
E
N
P
D
N
P
A
A
Y
-
Y
H
T
L
A
P
E
I
V
Q
E
L
G
T
N
L
T
S
F
V
A
G
I
G
S
G
G
T
F
A
G
T
A
R
Y
L
K
--
E
R
--
I
-
P
A
I
R
L
I
G
V
E
P
-----
E
G
S
-
I
------
L
N
G
G
-
E
------
P
G
P
H
E
I
E
G
I
G
V
E
F
I
P
P
F
F
E
N
L
D
I
D
G
F
E
T
I
S
D
E
E
G
F
S
Y
T
R
K
L
A
K
K
N
G
L
L
V
G
S
S
S
G
A
A
F
V
A
A
L
K
-
E
A
Q
-
R
L
---
P
E
-
G
S
Q
-
V
L
T
I
F
P
D
V
A
D
R
Y
L
S
K
G
I
Y
L
---
6
PsiBlast_PDB
76.35
40%
-56
- C2 -
2Q3C
2
CYSK_MYCTU
A:
[4-303]
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
--
R
R
V
T
----
D
G
-
A
-------
V
A
--
D
--
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
--
I
-
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
G
M
S
G
A
---
I
A
K
A
E
E
L
A
K
T
D
-
Q
R
Y
F
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
--
K
-
P
S
A
R
F
V
A
V
E
P
-----
A
A
S
P
V
------
L
S
G
G
-
Q
------
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
-
V
A
R
-
R
P
E--
N
A
-
G
K
L
-
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------
117
HHSearch
76.09
44%
19
- C2 -
1Z7W
2
CYSK1_ARATH
A:
[4-310]
-
R
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
--
N
N
V
-----
A
E
G
C
-------
V
G
--
R
--
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
--
G
E
S
--
V
-
L
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
---
P
A
---
K
G
M
K
G
A
---
I
A
K
A
E
E
I
L
A
K
T
-
P
N
G
Y
M
L
Q
-
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
--
E
Q
--
N
-
A
N
V
K
L
Y
G
V
E
P
-----
V
E
S
A
I
------
L
S
G
G
-
K
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
-
L
A
Q
-
R
P
E--
N
A
-
G
K
L
-
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
D
A
--
85
PsiBlast_CBE
75.79
35%
-54
- C2 -
2JC3
1
CYSM_SALTY
E:
[1-292]
---
M
N
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
--
Q
R
I
G
----
P
D
-
N
-------
G
S
--
E
--
I
W
V
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
--
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
G
M
E
G
A
---
R
D
L
A
L
A
M
-
S
E
R
-
G
E
G
K
L
L
D
-
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
R
Q
T
S
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
L
R
--
E
Q
--
E
-
K
P
V
T
I
V
G
L
Q
P
E----
E
G
S
-
S
------
I
P
G
--------------
I
R
R
W
P
A
E
Y
M
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
N
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
-
V
A
--
R
A
---
T
P
-
G
A
I
-
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
9
PsiBlast_PDB
75.77
44%
14
- C2 -
1Z7W
2
CYSK1_ARATH
A:
[5-309]
--
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
--
N
N
------
V
A
-
E
-------
G
C
--
V
G
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
--
G
E
S
--
V
-
L
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
---
P
A
---
K
G
M
K
G
A
---
I
A
K
A
E
E
I
L
A
K
T
-
P
N
G
Y
M
L
Q
-
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
--
E
Q
--
N
-
A
N
V
K
L
Y
G
V
E
P
-----
V
E
S
A
I
------
L
S
G
G
-
K
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
-
L
A
Q
-
R
P
E--
N
A
-
G
K
L
-
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
D
---
79
PsiBlast_CBE
75.56
35%
-52
- C2 -
2BHS
1
CYSM_ECOLI
C:
[2-292]
----
S
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
--
Q
R
M
G
----
P
D
-
N
-------
G
S
--
E
--
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
--
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
G
M
E
G
A
---
R
D
L
A
L
E
M
A
N
R
G
-
E
G
K
-
L
L
D
-
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
--
S
-
K
P
V
T
I
V
G
L
Q
P
E----
E
G
S
-
S
------
I
P
G
--------------
I
R
R
W
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
-
V
A
--
K
A
---
N
P
-
D
A
V
-
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
10
PsiBlast_PDB
75.25
44%
16
- C2 -
2ISQ
3
CYSK1_ARATH
A:
[3-307]
--
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
--
N
N
------
V
A
-
E
-------
G
C
--
V
G
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
--
G
E
S
--
V
-
L
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
---
P
A
---
K
G
M
K
G
A
---
I
A
K
A
E
E
I
L
A
K
T
-
P
N
G
Y
M
L
Q
-
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
--
E
Q
--
N
-
A
N
V
K
L
Y
G
V
E
P
-----
V
E
S
A
I
------
L
S
G
G
-
K
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
-
L
A
Q
-
R
P
E--
N
A
-
G
K
L
-
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
D
---
12
PsiBlast_PDB
75.13
44%
17
- C2 -
1Z7Y
1
CYSK1_ARATH
A:
[5-309]
--
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
--
N
N
------
V
A
-
E
-------
G
C
--
V
G
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
A
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
--
G
E
S
--
V
-
L
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
---
P
A
---
K
G
M
K
G
A
---
I
A
K
A
E
E
I
L
A
K
T
-
P
N
G
Y
M
L
Q
-
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
--
E
Q
--
N
-
A
N
V
K
L
Y
G
V
E
P
-----
V
E
S
A
I
------
L
S
G
G
-
K
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
-
L
A
Q
-
R
P
E--
N
A
-
G
K
L
-
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
D
---
7
PsiBlast_PDB
75.02
41%
-64
- C- -
3RR2
-
?
A:
[1-299]
M
T
I
A
E
N
I
T
Q
L
I
G
G
T
P
L
V
R
L
--
R
R
V
T
----
D
G
-
A
-------
A
A
--
D
--
V
V
A
K
L
E
S
F
N
P
A
G
S
I
K
D
R
I
G
V
A
M
I
D
A
A
E
K
A
G
L
I
K
P
--
D
-
T
--
I
-
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
S
A
A
R
G
Y
K
C
V
L
T
M
P
D
T
M
S
I
E
R
R
M
L
L
R
A
Y
G
A
E
L
V
L
T
P
----------
M
A
G
A
---
I
A
K
A
E
E
L
A
K
T
D
-
D
R
Y
F
I
P
Q
-
Q
F
E
N
P
A
N
P
A
V
H
-
A
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
F
V
S
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
Q
R
--
R
-
P
S
A
Q
F
V
A
V
E
P
-----
A
A
S
P
V
------------------
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
L
A
L
V
D
E
V
I
T
V
G
N
D
D
A
L
E
L
A
R
R
M
A
T
E
E
G
L
L
V
G
I
S
S
G
A
A
V
W
A
A
R
E
-
L
A
H
-
R
P
E--
N
A
-
G
K
L
-
I
V
V
V
L
P
D
F
G
E
R
Y
----------
81
PsiBlast_CBE
74.73
35%
-50
- C2 -
2BHS
1
CYSM_ECOLI
A:
[2-292]
----
S
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
--
Q
R
M
G
----
P
D
-
N
-------
G
S
--
E
--
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
--
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
G
M
E
G
A
---
R
D
L
A
L
E
M
A
N
R
G
-
E
G
K
-
L
L
D
-
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
--
S
-
K
P
V
T
I
V
G
L
Q
P
E
----
E
G
S
-
S
------
I
P
G
--------------
I
R
R
W
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
-
V
A
--
K
A
---
N
P
-
D
A
V
-
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
124
HHSearch
74.52
38%
-7
- C2 -
3TBH
2
?
A:
[12-314]
---
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
--
N
K
L
-----
N
N
-
T
-------
K
A
--
K
--
V
V
L
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
--
G
K
S
--
I
-
V
V
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
---
A
A
---
L
G
M
K
G
A
---
V
A
M
A
K
K
I
V
A
A
N
-
P
N
A
V
L
A
D
-
Q
F
A
T
K
Y
N
A
L
I
H
-
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
N
V
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
--
K
M
--
G
-
S
H
A
R
I
V
A
V
E
P
-----
T
E
S
P
V
------
L
S
G
G
-
K
------
P
G
P
H
K
I
Q
G
I
G
P
G
F
V
P
D
V
L
D
R
S
L
I
D
E
V
L
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
-
I
A
E
-
R
P
E--
M
E
-
G
K
T
-
I
V
T
V
I
P
S
F
G
E
R
Y
L
S
T
T
L
Y
R
---
115
HHSearch
74.03
42%
3
- C2 -
2Q3B
5
CYSK_MYCTU
A:
[4-303]
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
--
R
R
V
-----
T
D
G
A
-------
V
A
--
D
--
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
--
I
-
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
---
G
A
---
D
G
M
S
G
A
---
I
A
K
A
E
E
L
A
K
T
D
-
Q
R
Y
F
V
P
Q
-
Q
F
E
N
P
A
N
P
-
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
--
K
-
P
S
A
R
F
V
A
V
E
P
-----
A
A
S
P
V
------
L
S
G
G
-
Q
------
K
G
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
-
V
A
R
-
R
P
E--
N
A
-
G
K
L
-
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------
90
PsiBlast_CBE
73.78
38%
-10
- C2 -
1D6S
2
CYSK_SALTY
B:
[11-311]
----------
I
G
H
T
P
L
V
R
L
--
N
R
I
G
---------------
N
G
--
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
-
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
--
K
-
T
D
L
I
T
V
A
V
E
P
TDSPV
I
A
Q
-
A
------
L
A
G
E
-
E
IK----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
---
F
T
-
N
K
N
-
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
----
128
HHSearch
73.52
39%
20
- C2 -
3PC3
2
?
A:
[50-362]
--
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
--
N
N
I
-----
P
A
S
D
GI-----
E
C
--
E
--
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
--
G
-
Y
--
T
-
I
I
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
---
T
E
AA-
Y
D
--
S
P
EG
L
I
Y
V
A
Q
Q
L
Q
R
E
T
-
P
N
S
I
V
L
D
-
Q
Y
R
N
A
G
N
P
L
A
H
-
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
--
E
Q
--
V
-
P
S
C
Q
I
V
G
V
D
P
-----
Y
G
S
I
L
------
A
R
P
A
-
E
LNKTD-
V
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
-
H
A
R
-
K
L
---
K
K
-
G
Q
R
-
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
F
V
S
D
---
80
PsiBlast_CBE
73.49
35%
-48
- C2 -
2BHS
1
CYSM_ECOLI
B:
[2-292]
----
S
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
--
Q
R
M
G
----
P
D
-
N
-------
G
S
--
E
--
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
--
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
G
M
E
G
A
---
R
D
L
A
L
E
M
A
N
R
G
-
E
G
K
-
L
L
D
-
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
--
S
-
K
P
V
T
I
V
G
L
Q
P
E----
E
G
S
-
S
------
I
P
G
--------------
I
R
R
W
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
-
V
A
--
K
A
---
N
P
-
D
A
V
-
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
91
PsiBlast_CBE
73.37
38%
-10
- C2 -
1D6S
2
CYSK_SALTY
A:
[11-311]
----------
I
G
H
T
P
L
V
R
L
--
N
R
I
G
---------------
N
G
--
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
-
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
--
K
-
T
D
L
I
T
V
A
V
E
P
TDSP
V
I
A
Q
-
A
------
L
A
G
E
-
E
I
K
----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
---
F
T
-
N
K
N
-
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
----
50
PsiBlast_CBE
73.13
40%
12
- C2 -
2EFY
2
?
B:
[7-301]
----------
I
G
K
T
P
V
V
R
L
--
A
K
V
V
----
E
P
-
D
-------
M
A
--
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
--
G
-
S
GQ
V
-
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
A
---
R
E
E
A
L
R
L
K
E
E
L
--
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
--
I
-
P
H
V
K
V
I
A
V
E
P
-----
A
R
S
N
V
------
L
S
G
G
-
K
------
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
-
V
A
R
-
E
L
---
G
P
-
G
K
R
-
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
----
98
PsiBlast_CBE
73.02
37%
-5
- C2 -
3TBH
2
?
A:
[11-314]
--
V
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
--
N
K
L
N
----
N
T
-
K
-------
A
K
--
V
--
V
L
-
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
--
G
K
S
--
I
-
V
V
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
---
A
A
---
L
G
M
K
G
A
---
V
A
M
A
K
K
I
V
A
A
N
-
P
N
A
V
L
A
D
-
Q
F
A
T
K
Y
N
A
L
I
H
-
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
N
V
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
--
K
M
--
G
-
S
H
A
R
I
V
A
V
E
P
-----
T
E
S
P
V
------
L
S
G
G
-
K
------
P
G
P
H
K
I
Q
G
I
G
P
G
F
V
P
D
V
L
D
R
S
L
I
D
E
V
L
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
-
I
A
E
-
R
P
---
E
M
E
G
K
T
-
I
V
T
V
I
P
S
F
G
E
R
Y
L
S
T
T
L
Y
R
---
78
PsiBlast_CBE
72.99
35%
-51
- C2 -
2BHS
1
CYSM_ECOLI
D:
[2-292]
----
S
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
--
Q
R
M
G
----
P
D
-
N
-------
G
S
--
E
--
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
--
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
G
M
E
G
A
---
R
D
L
A
L
E
M
A
N
R
G
-
E
G
K
-
L
L
D
-
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
--
S
-
K
P
V
T
I
V
G
L
Q
P
E----
E
G
S
-
S
------
I
P
G
--------------
I
R
R
W
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
-
V
A
--
K
A
---
N
P
-
D
A
V
-
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
64
PsiBlast_CBE
72.66
39%
6
- C2 -
3VBE
1
?
A:
[29-329]
------
V
S
Q
L
I
G
R
T
P
L
V
Y
L
--
N
K
V
T
----
E
G
-
C
-------
G
A
--
Y
--
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
P
--
G
-
K
--
T
T
L
I
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
---
P
A
---
K
G
M
G
G
T
---
V
K
K
A
Y
E
L
L
E
N
T
-
P
N
A
H
M
L
Q
-
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
N
G
Q
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
--
S
K
--
N
-
P
N
V
K
I
Y
G
V
E
P
-----
S
E
S
N
V
------
L
N
G
G
-
K
------
P
G
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
-
L
A
Q
L
P
E
---
N
K
-
G
K
L
-
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
---
116
HHSearch
72.53
42%
21
- C2 -
4AEC
3
CYSKM_ARATH
A:
[112-416]
-
N
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
--
N
S
I
-----
A
K
G
C
-------
V
A
--
N
--
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
P
--
G
K
S
--
V
-
L
V
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
---
P
A
---
K
G
M
T
G
A
---
V
Q
K
A
E
E
I
L
K
N
T
-
P
D
A
Y
M
L
Q
-
Q
F
D
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
K
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
--
E
K
--
N
-
P
K
T
Q
V
I
G
V
E
P
-----
T
E
S
D
I
------
L
S
G
G
-
K
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
-
V
A
K
-
R
P
E--
N
A
-
G
K
L
-
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
T
P
L
F
----
73
PsiBlast_CBE
72.09
39%
-6
- C2 -
1OAS
1
CYSK_SALTY
A:
[11-311]
----------
I
G
H
T
P
L
V
R
L
--
N
R
I
G
---------------
N
G
--
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
-
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
--
K
-
T
D
L
I
T
V
A
V
E
P
TDSP
V
I
A
Q
-
A
------
L
A
G
E
-
E
I
K
----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
---
F
T
-
N
K
N
-
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
----
51
PsiBlast_CBE
71.96
40%
9
- C2 -
2EFY
2
?
A:
[7-301]
----------
I
G
K
T
P
V
V
R
L
--
A
K
V
V
----
E
P
-
D
-------
M
A
--
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
--
G
-
S
G
Q
V
-
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
A
---
R
E
E
A
L
R
L
K
E
E
L
--
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
--
I
-
P
H
V
K
V
I
A
V
E
P
-----
A
R
S
N
V
------
L
S
G
G
-
K
------
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
-
V
A
R
-
E
L
---
G
P
-
G
K
R
-
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
----
54
PsiBlast_CBE
71.95
40%
10
- C2 -
1VE1
1
?
A:
[7-301]
----------
I
G
K
T
P
V
V
R
L
--
A
K
V
V
----
E
P
-
D
-------
M
A
--
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
--
G
-
S
G
Q
V
-
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
A
---
R
E
E
A
L
R
L
K
E
E
L
--
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
--
I
-
P
H
V
K
V
I
A
V
E
P
-----
A
R
S
N
V
------
L
S
G
G
-
K
------
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
-
V
A
R
-
E
L
---
G
P
-
G
K
R
-
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
----
99
PsiBlast_CBE
71.89
37%
-1
- C2 -
3T4P
3
?
A:
[11-314]
--
V
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
--
N
K
L
N
----
N
T
-
K
-------
A
K
--
V
--
V
L
-
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
--
G
K
S
--
I
-
V
V
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
---
A
A
---
L
G
M
K
G
A
---
V
A
M
A
K
K
I
V
A
A
N
-
P
N
A
V
L
A
D
-
Q
F
A
T
K
Y
N
A
L
I
H
-
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
N
V
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
--
K
M
--
G
-
S
H
A
R
I
V
A
V
E
P
-----
T
E
S
P
V
------
L
S
G
G
-
K
------
P
G
P
H
K
I
Q
G
I
G
P
G
F
V
P
D
V
L
D
R
S
L
I
D
E
V
L
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
-
I
A
E
-
R
P
---
E
M
E
G
K
T
-
I
V
T
V
I
P
S
F
G
E
R
Y
L
S
T
T
L
Y
R
---
55
PsiBlast_CBE
71.89
39%
16
- C2 -
4LMA
2
?
B:
[8-316]
M
R
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
--
N
R
I
P
----
Q
A
-
E
-------
G
C
LG
R
--
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
L
I
N
P
E-
T
-
T
--
V
-
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
---
G
S
---
Q
G
M
K
G
A
---
I
L
R
A
Q
Q
I
V
D
S
I
-
P
G
A
Y
M
L
Q
-
Q
F
R
N
P
S
N
P
E
I
H
-
R
L
T
T
A
E
E
I
W
Q
D
T
E
G
Q
V
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
--
S
R
--
K
-
P
S
F
Q
V
V
A
V
E
P
-----
F
N
S
P
V
------
I
S
G
G
-
N
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
N
L
C
A
A
I
Q
-
L
A
Q
-
R
P
E--
N
E
-
G
K
L
-
I
V
V
I
Q
P
S
F
G
E
R
Y
L
S
T
L
M
F
Q
---
52
PsiBlast_CBE
71.78
40%
12
- C2 -
2ECQ
2
?
A:
[7-301]
----------
I
G
K
T
P
V
V
R
L
--
A
K
V
V
----
E
P
-
D
-------
M
A
--
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
--
G
-
S
G
Q
V
-
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
A
---
R
E
E
A
L
R
L
K
E
E
L
--
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
--
I
-
P
H
V
K
V
I
A
V
E
P
-----
A
R
S
N
V
------
L
S
G
G
-
K
------
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
-
V
A
R
-
E
L
---
G
P
-
G
K
R
-
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
----
42
PsiBlast_CBE
71.72
40%
7
- C2 -
4AEC
4
CYSKM_ARATH
B:
[111-417]
L
N
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
--
N
S
I
A
----
K
G
-
C
-------
V
A
--
N
--
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
P
--
G
K
S
--
V
-
L
V
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
---
P
A
---
K
G
M
T
G
A
---
V
Q
K
A
E
E
I
L
K
N
T
-
P
D
A
Y
M
L
Q
-
Q
F
D
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
K
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
--
E
K
--
N
-
P
K
T
Q
V
I
G
V
E
P
-----
T
E
S
D
I
------
L
S
G
G
-
K
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
-
V
A
K
-
R
P
E--
N
A
-
G
K
L
-
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
T
P
L
F
Q
---
63
PsiBlast_CBE
71.66
39%
7
- C2 -
3VBE
1
?
B:
[29-329]
------
V
S
Q
L
I
G
R
T
P
L
V
Y
L
--
N
K
V
T
----
E
G
-
C
-------
G
A
--
Y
--
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
P
--
G
-
K
--
T
T
L
I
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
---
P
A
---
K
G
M
G
G
T
---
V
K
K
A
Y
E
L
L
E
N
T
-
P
N
A
H
M
L
Q
-
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
N
G
Q
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
--
S
K
--
N
-
P
N
V
K
I
Y
G
V
E
P
-----
S
E
S
N
V
------
L
N
G
G
-
K
------
P
G
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
-
L
A
Q
L
P
E
---
N
K
-
G
K
L
-
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
---
102
Fugue
71.43
39%
-10
- C2 -
1OAS
1
CYSK_SALTY
A:
[1-315]
S
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
--
N
R
I
G
----
N
G
-
R
--------------
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
-
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
--
G
T
KG
K
-
T
D
L
I
T
V
A
V
E
P
-----
T
D
S
P
V
------
I
A
Q
A
-
L
A
GE
E
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
-
L
Q
E
-
D
E
---
S
F
T
N
K
N
-
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
F
72
PsiBlast_CBE
71.37
39%
-7
- C2 -
1OAS
1
CYSK_SALTY
B:
[11-311]
----------
I
G
H
T
P
L
V
R
L
--
N
R
I
G
---------------
N
G
--
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
-
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
--
K
-
T
D
L
I
T
V
A
V
E
P
TDSPV
I
A
Q
-
A
------
L
A
G
E
-
E
IK----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
---
F
T
-
N
K
N
-
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
----
56
PsiBlast_CBE
71.14
39%
17
- C2 -
4LMA
3
?
A:
[8-316]
M
R
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
--
N
R
I
P
----
Q
A
-
E
-------
G
C
L
G
R
--
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
L
I
N
P
E-
T
-
T
--
V
-
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
---
G
S
---
Q
G
M
K
G
A
---
I
L
R
A
Q
Q
I
V
D
S
I
-
P
G
A
Y
M
L
Q
-
Q
F
R
N
P
S
N
P
E
I
H
-
R
L
T
T
A
E
E
I
W
Q
D
T
E
G
Q
V
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
--
S
R
--
K
-
P
S
F
Q
V
V
A
V
E
P
-----
F
N
S
P
V
------
I
S
G
G
-
N
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
N
L
C
A
A
I
Q
-
L
A
Q
-
R
P
E--
N
E
-
G
K
L
-
I
V
V
I
Q
P
S
F
G
E
R
Y
L
S
T
L
M
F
Q
---
43
PsiBlast_CBE
71.10
40%
6
- C2 -
4AEC
3
CYSKM_ARATH
A:
[111-417]
L
N
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
--
N
S
I
A
----
K
G
-
C
-------
V
A
--
N
--
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
P
--
G
K
S
--
V
-
L
V
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
---
P
A
---
K
G
M
T
G
A
---
V
Q
K
A
E
E
I
L
K
N
T
-
P
D
A
Y
M
L
Q
-
Q
F
D
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
K
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
--
E
K
--
N
-
P
K
T
Q
V
I
G
V
E
P
-----
T
E
S
D
I
------
L
S
G
G
-
K
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
-
V
A
K
-
R
P
E--
N
A
-
G
K
L
-
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
T
P
L
F
Q
---
122
HHSearch
70.92
38%
-8
- C2 -
1Y7L
2
CYSK_HAEIN
A:
[2-311]
-
A
I
Y
A
D
N
S
Y
S
I
G
N
T
P
L
V
R
L
--
K
H
F
-----
G
H
---------
N
G
--
N
--
V
V
V
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
K
--
G
-
K
--
E
-
I
V
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
A
K
A
E
E
I
V
A
S
D
P
S
R
Y
V
M
L
K
-
Q
F
E
N
P
A
N
P
Q
I
H
-
R
E
T
T
G
P
E
I
W
K
D
T
D
G
K
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
--
L
D
--
F
G
K
Q
I
T
S
V
A
V
E
P
-----
V
E
S
P
V
------
I
S
Q
T
L
A
GE
E
V
K
-
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
D
R
-
L
A
K
-
L
P
E--
F
A
-
D
K
L
-
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
T
A
L
F
----
119
HHSearch
70.80
38%
17
- C2 -
4LMB
3
?
A:
[8-316]
M
L
I
A
R
D
I
T
Q
L
V
G
R
T
P
L
V
Q
L
--
N
R
I
-----
P
V
A
E
GV-----
K
A
--
R
--
I
V
V
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
L
I
H
P
--
D
K
T
--
I
-
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
P
---
G
S
---
Q
G
M
E
G
A
---
I
T
R
A
E
E
I
V
E
N
T
-
P
N
A
Y
S
L
Q
-
Q
F
R
N
P
A
N
P
K
I
H
-
R
E
T
T
A
E
E
I
W
A
D
T
D
G
L
V
D
I
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
--
P
R
--
R
-
P
Q
F
Q
A
I
A
V
E
P
-----
S
N
S
P
V
------
L
S
G
G
-
Q
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
A
L
W
A
A
I
Q
-
V
G
K
-
R
P
E--
N
E
-
D
K
L
-
I
V
M
I
Q
P
S
F
G
E
R
Y
L
S
T
A
L
F
K
---
123
HHSearch
70.58
40%
14
* C2 *
1VE1
1
?
A:
[2-302]
-----
R
V
E
G
A
I
G
K
T
P
V
V
R
L
--
A
K
V
-----
V
E
P
D
-------
M
A
--
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
GS
G
-
Q
--
V
-
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
A
---
R
E
E
A
L
R
L
K
E
-
E
-
L
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
--
I
-
P
H
V
K
V
I
A
V
E
P
-----
A
R
S
N
V
------
L
S
G
G
-
K
------
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
-
V
A
R
-
E
L
---
G
P
-
G
K
R
-
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
A
---
62
PsiBlast_CBE
70.58
39%
9
- C2 -
3VBE
1
?
C:
[29-329]
------
V
S
Q
L
I
G
R
T
P
L
V
Y
L
--
N
K
V
T
----
E
G
-
C
-------
G
A
--
Y
--
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
P
--
G
-
K
--
T
T
L
I
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
---
P
A
---
K
G
M
G
G
T
---
V
K
K
A
Y
E
L
L
E
N
T
-
P
N
A
H
M
L
Q
-
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
N
G
Q
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
--
S
K
--
N
-
P
N
V
K
I
Y
G
V
E
P
-----
S
E
S
N
V
------
L
N
G
G
-
K
------
P
G
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
-
L
A
Q
L
P
E
---
N
K
-
G
K
L
-
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
---
58
PsiBlast_CBE
70.53
39%
29
- C2 -
3PC4
3
?
A:
[50-358]
--
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
--
N
N
I
P
----
A
S
-
D
-------
G
I
--
E
C
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
--
G
-
Y
--
T
-
I
I
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
---
T
E
AAY
D
S
P
E
G
L
---
I
Y
V
A
Q
Q
L
Q
R
E
T
-
P
N
S
I
V
L
D
-
Q
Y
R
N
A
G
N
P
L
A
H
-
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
--
E
Q
--
V
-
P
S
C
Q
I
V
G
V
D
P
-----
Y
G
S
-
I
LARPAE
L
N
K
T
-
D
------
V
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
-
H
A
R
-
K
L
---
K
K
-
G
Q
R
-
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
-------
53
PsiBlast_CBE
70.40
40%
10
- C2 -
2ECO
2
?
A:
[7-301]
----------
I
G
K
T
P
V
V
R
L
--
A
K
V
V
----
E
P
-
D
-------
M
A
--
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
--
G
-
S
G
Q
V
-
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
---
P
E
---
R
R
M
L
A
A
---
R
E
E
A
L
R
L
K
E
E
L
--
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
--
I
-
P
H
V
K
V
I
A
V
E
P
-----
A
R
S
N
V
------
L
S
G
G
-
K
------
M
G
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
-
V
A
R
-
E
L
---
G
P
-
G
K
R
-
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
----
76
PsiBlast_CBE
70.33
39%
-1
- C2 -
1FCJ
3
CYSK_SALTY
B:
[11-304]
----------
I
G
H
T
P
L
V
R
L
--
N
R
I
G
---------------
N
G
--
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
-
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
--
K
-
T
D
L
I
T
V
A
V
E
P
TDSPV
I
A
Q
-
A
------
L
A
G
E
-
E
IK----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
---
F
T
-
N
K
N
-
I
V
V
I
L
P
S
S
G
E
R
-----------
59
PsiBlast_CBE
70.13
39%
30
- C2 -
3PC3
2
?
A:
[50-358]
--
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
--
N
N
I
P
----
A
S
-
D
-------
G
I
--
E
C
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
--
G
-
Y
--
T
-
I
I
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
---
T
E
AAY
D
S
P
E
G
L
---
I
Y
V
A
Q
Q
L
Q
R
E
T
-
P
N
S
I
V
L
D
-
Q
Y
R
N
A
G
N
P
L
A
H
-
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
--
E
Q
--
V
-
P
S
C
Q
I
V
G
V
D
P
-----
Y
G
S
-
I
LARPAE
L
N
K
T
-
D
------
V
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
-
H
A
R
-
K
L
---
K
K
-
G
Q
R
-
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
-------
77
PsiBlast_CBE
69.84
39%
-4
- C2 -
1FCJ
3
CYSK_SALTY
A:
[11-302]
----------
I
G
H
T
P
L
V
R
L
--
N
R
I
G
---------------
N
G
--
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
-
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
--
K
-
T
D
L
I
T
V
A
V
E
P
TDSP
V
I
A
Q
-
A
------
L
A
G
E
-
E
I
K
----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
---
F
T
-
N
K
N
-
I
V
V
I
L
P
S
S
G
-------------
61
PsiBlast_CBE
69.80
39%
6
- C2 -
3VBE
1
?
D:
[29-329]
------
V
S
Q
L
I
G
R
T
P
L
V
Y
L
--
N
K
V
T
----
E
G
-
C
-------
G
A
--
Y
--
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
P
--
G
-
K
--
T
T
L
I
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
---
P
A
---
K
G
M
G
G
T
---
V
K
K
A
Y
E
L
L
E
N
T
-
P
N
A
H
M
L
Q
-
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
N
G
Q
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
--
S
K
--
N
-
P
N
V
K
I
Y
G
V
E
P
-----
S
E
S
N
V
------
L
N
G
G
-
K
------
P
G
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
-
L
A
Q
L
P
E
---
N
K
-
G
K
L
-
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
---
60
PsiBlast_CBE
69.71
39%
31
- C2 -
3PC2
2
?
A:
[50-358]
--
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
--
N
N
I
P
----
A
S
-
D
-------
G
I
--
E
C
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
--
G
-
Y
--
T
-
I
I
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
---
T
E
AAY
D
S
P
E
G
L
---
I
Y
V
A
Q
Q
L
Q
R
E
T
-
P
N
S
I
V
L
D
-
Q
Y
R
N
A
G
N
P
L
A
H
-
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
--
E
Q
--
V
-
P
S
C
Q
I
V
G
V
D
P
-----
Y
G
S
-
I
LARPAE
L
N
K
T
-
D
------
V
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
-
H
A
R
-
K
L
---
K
K
-
G
Q
R
-
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
-------
75
PsiBlast_CBE
69.26
39%
-2
- C2 -
1FCJ
3
CYSK_SALTY
C:
[11-304]
----------
I
G
H
T
P
L
V
R
L
--
N
R
I
G
---------------
N
G
--
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
-
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
--
K
-
T
D
L
I
T
V
A
V
E
P
TDSPV
I
A
Q
-
A
------
L
A
G
E
-
E
IK----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
---
F
T
-
N
K
N
-
I
V
V
I
L
P
S
S
G
E
R
-----------
71
PsiBlast_CBE
69.24
38%
-31
- C2 -
4AIR
5
?
B:
[32-335]
--
V
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
--
N
K
L
N
----
N
T
-
K
-------
A
K
--
V
--
V
L
-
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
--
G
K
S
--
V
-
V
V
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
---
A
A
---
L
G
M
K
G
A
---
V
T
M
A
K
K
I
V
T
A
N
-
P
N
A
V
L
A
D
-
Q
F
A
T
K
Y
N
A
L
I
H
-
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
N
V
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
--
K
M
--
G
-
S
H
A
R
I
V
A
V
E
P
-----
M
E
---------------------------------------
D
R
S
L
I
D
E
V
F
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
-
I
A
E
-
R
P
---
E
M
E
G
K
T
-
I
V
T
I
I
P
S
F
G
E
R
Y
L
S
T
A
L
Y
R
---
31
PsiBlast_CBE
68.94
38%
33
- C2 -
4L0D
2
CBS_HUMAN
B:
[76-387]
--
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
--
N
K
I
G
----
K
K
-
F
-------
G
L
--
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
-
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
TNA
R
F
---
D
S
P
E
S
H
---
V
G
V
A
W
R
L
K
N
E
I
-
P
N
S
H
I
L
D
-
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
--
C
-
P
G
C
R
I
I
G
V
D
P
-----
E
G
S
-
I
LAEPEE
L
N
Q
T
-
E
------
Q
T
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
-
A
A
Q
-
E
L
---
Q
E
-
G
Q
R
-
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-------
92
PsiBlast_CBE
68.91
37%
28
- C2 -
2PQM
2
?
B:
[16-320]
-----
N
I
L
E
T
I
G
G
T
P
L
V
E
L
--
H
G
V
T
EHPR
I
K
-
K
-------
G
T
--
R
--
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
--
G
-
M
--
E
-
I
I
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
A
---
I
E
E
V
N
K
M
I
K
E
N
-
P
G
K
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
A
N
-
E
I
W
E
D
T
D
G
E
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
--
K
-
K
G
I
K
I
I
A
V
E
P
-----
E
E
S
A
V
------
L
E
G
K
-
A
------
K
G
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
-
E
A
E
-
K
P
E--
N
E
-
G
K
T
-
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
K
---
74
PsiBlast_CBE
68.82
39%
-4
- C2 -
1FCJ
3
CYSK_SALTY
D:
[11-302]
----------
I
G
H
T
P
L
V
R
L
--
N
R
I
G
---------------
N
G
--
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
-
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
---
G
A
---
K
G
M
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
--
K
-
T
D
L
I
T
V
A
V
E
P
TDSPV
I
A
Q
-
A
------
L
A
G
E
-
E
IK----
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
-
E
S
---
F
T
-
N
K
N
-
I
V
V
I
L
P
S
S
G
-------------
93
PsiBlast_CBE
68.68
37%
24
- C2 -
2PQM
2
?
A:
[16-320]
-----
N
I
L
E
T
I
G
G
T
P
L
V
E
L
--
H
G
V
T
EHPR
I
K
-
K
-------
G
T
--
R
--
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
--
G
-
M
--
E
-
I
I
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
A
---
I
E
E
V
N
K
M
I
K
E
N
-
P
G
K
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
A
N
-
E
I
W
E
D
T
D
G
E
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
--
K
-
K
G
I
K
I
I
A
V
E
P
-----
E
E
S
A
V
------
L
E
G
K
-
A
------
K
G
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
-
E
A
E
-
K
P
E--
N
E
-
G
K
T
-
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
K
---
95
PsiBlast_CBE
68.27
37%
23
- C2 -
3BM5
3
?
A:
[15-319]
-----
N
I
L
E
T
I
G
G
T
P
L
V
E
L
--
H
G
V
T
EHPR
I
K
-
K
-------
G
T
--
R
--
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
--
G
-
M
--
E
-
I
I
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
A
---
I
E
E
V
N
K
M
I
K
E
N
-
P
G
K
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
A
N
-
E
I
W
E
D
T
D
G
E
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
--
K
-
K
G
I
K
I
I
A
V
E
P
-----
E
E
S
A
V
------
L
E
G
K
-
A
------
K
G
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
-
E
A
E
-
K
P
E--
N
E
-
G
K
T
-
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
K
---
32
PsiBlast_CBE
68.05
38%
35
- C2 -
4COO
6
CBS_HUMAN
B:
[98-415]
--
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
--
N
K
I
G
----
K
K
-
F
-------
G
L
--
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
-
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
TNA
R
F
---
D
S
P
E
S
H
---
V
G
V
A
W
R
L
K
N
E
I
-
P
N
S
H
I
L
D
-
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
--
C
-
P
G
C
R
I
I
G
V
D
P
-----
E
G
S
-
I
LAEPEE
L
N
Q
T
-
E
------
Q
T
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
-
A
A
Q
-
E
L
---
Q
E
-
G
Q
R
-
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-------
129
HHSearch
68.01
35%
1
- C2 -
2V03
3
CYSM_ECOLI
A:
[3-293]
-----
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
--
Q
R
M
-----
G
P
D
N
-------
G
S
--
E
--
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
--
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
---
K
E
---
Q
G
M
E
G
A
---
R
D
L
A
L
E
M
A
N
-
R
-
G
E
G
K
L
L
D
-
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
--
S
-
K
P
V
T
I
V
G
L
Q
P
-----
E
E
G
S
S
------
I
P
G
I
-
R
-------------
R
W
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
-
V
A
A
-
A
N
----
P
-
D
A
V
-
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
G
---
20
PsiBlast_PDB
67.95
38%
26
- C2 -
4PCU
2
CBS_HUMAN
A:
[76-389]
--
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
--
N
K
I
G
----
K
K
-
F
-------
G
L
--
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
-
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
A--
R
F
---
D
S
P
S
S
H
---
V
G
V
A
W
R
L
K
N
E
I
-
P
N
S
H
I
L
D
-
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
--
C
-
P
G
C
R
I
I
G
V
D
P
-----
E
G
S
-
I
LAEPEE
L
N
Q
T
-
E
------
Q
T
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
-
A
A
Q
-
E
L
---
Q
E
-
G
Q
R
-
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-------
16
PsiBlast_PDB
67.82
38%
34
- C2 -
4COO
9
CBS_HUMAN
A:
[98-409]
--
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
--
N
K
I
G
----
K
K
-
F
-------
G
L
--
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
-
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
TNA
R
F
---
D
S
P
E
S
H
---
V
G
V
A
W
R
L
K
N
E
I
-
P
N
S
H
I
L
D
-
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
--
C
-
P
G
C
R
I
I
G
V
D
P
-----
E
G
S
-
I
LAEPEE
L
N
Q
T
-
E
------
Q
T
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
-
A
A
Q
-
E
L
---
Q
E
-
G
Q
R
-
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-------
94
PsiBlast_CBE
67.64
37%
26
- C2 -
3BM5
4
?
B:
[15-319]
-----
N
I
L
E
T
I
G
G
T
P
L
V
E
L
--
H
G
V
T
EHPR
I
K
-
K
-------
G
T
--
R
--
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
--
G
-
M
--
E
-
I
I
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
A
---
I
E
E
V
N
K
M
I
K
E
N
-
P
G
K
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
T
A
N
-
E
I
W
E
D
T
D
G
E
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
--
K
-
K
G
I
K
I
I
A
V
E
P
-----
E
E
S
A
V
------
L
E
G
K
-
A
------
K
G
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
-
E
A
E
-
K
P
E--
N
E
-
G
K
T
-
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
K
---
15
PsiBlast_PDB
67.57
38%
34
- C2 -
4L0D
2
CBS_HUMAN
A:
[76-388]
--
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
--
N
K
I
G
----
K
K
-
F
-------
G
L
--
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
-
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
TNA
R
F
---
D
S
P
E
S
H
---
V
G
V
A
W
R
L
K
N
E
I
-
P
N
S
H
I
L
D
-
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
--
C
-
P
G
C
R
I
I
G
V
D
P
-----
E
G
S
-
I
LAEPEE
L
N
Q
T
-
E
------
Q
T
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
-
A
A
Q
-
E
L
---
Q
E
-
G
Q
R
-
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-------
57
PsiBlast_CBE
67.35
38%
22
- C2 -
4LMB
3
?
A:
[8-316]
M
L
I
A
R
D
I
T
Q
L
V
G
R
T
P
L
V
Q
L
--
N
R
I
P
----
V
A
-
E
-------
G
V
--
K
A
R
I
V
V
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
L
I
H
P
--
D
-
K
T-
I
-
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
P
---
G
S
---
Q
G
M
E
G
A
---
I
T
R
A
E
E
I
V
E
N
T
-
P
N
A
Y
S
L
Q
-
Q
F
R
N
P
A
N
P
K
I
H
-
R
E
T
T
A
E
E
I
W
A
D
T
D
G
L
V
D
I
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
--
P
R
--
R
-
P
Q
F
Q
A
I
A
V
E
P
-----
S
N
S
P
V
------
L
S
G
G
-
Q
------
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
A
L
W
A
A
I
Q
-
V
G
K
-
R
P
---
E
N
-
E
D
K
L
I
V
M
I
Q
P
S
F
G
E
R
Y
L
S
T
A
L
F
K
---
125
HHSearch
66.57
37%
47
- C2 -
2PQM
2
?
A:
[12-320]
-
R
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
--
H
G
V
-----
T
E
H
P
RIKK---
G
T
--
R
--
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
--
G
-
M
--
E
-
I
I
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
---
G
K
---
K
G
M
P
G
A
---
I
E
E
V
N
K
M
I
K
E
N
P
G
K
Y
F
V
A
N
-
Q
F
G
N
P
D
N
T
-
A
A
-
H
H
Y
T
A
N
E
I
W
E
D
T
D
G
E
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
--
K
-
K
G
I
K
I
I
A
V
E
P
-----
E
E
S
A
V
------
L
E
G
K
-
A
------
K
G
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
-
E
A
E
-
K
P
E--
N
E
-
G
K
T
-
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
K
---
41
PsiBlast_CBE
66.09
38%
33
- C2 -
4PCU
2
CBS_HUMAN
B:
[76-390]
--
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
--
N
K
I
G
----
K
K
-
F
-------
G
L
--
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
-
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
TNA
R
F
---
D
S
P
S
S
H
---
V
G
V
A
W
R
L
K
N
E
I
-
P
N
S
H
I
L
D
-
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
--
C
-
P
G
C
R
I
I
G
V
D
P
-----
E
G
S
-
I
LAEPEE
L
N
Q
T
-
E
------
Q
T
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
-
A
A
Q
-
E
L
---
Q
E
-
G
Q
R
-
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-------
127
HHSearch
64.33
36%
26
- C2 -
3DWG
1
CYSM_MYCTU
A:
[3-310]
M
T
R
Y
D
S
L
L
Q
A
L
G
N
T
P
L
V
G
L
--
Q
R
L
-----
S
P
R
W
DDGRD
G
P
H
V
--
R
--
L
W
A
K
L
E
D
R
N
P
T
G
S
I
K
D
R
P
A
V
R
M
I
E
Q
A
E
A
D
G
L
L
R
P
--
G
-
A
--
T
-
I
L
E
P
T
S
G
N
T
G
I
S
L
A
M
A
A
R
L
K
G
Y
R
L
I
C
V
M
P
E
N
T
S
V
E
R
R
Q
L
L
E
L
Y
G
A
Q
I
I
F
S
A
---
A
E
---
G
G
S
N
T
A
---
V
A
T
A
K
E
L
A
A
T
N
-
P
S
W
V
M
L
Y
-
Q
Y
G
N
P
A
N
T
D
S
H
-
Y
C
G
T
G
P
E
L
L
A
D
L
P
-
E
I
T
H
F
V
A
G
L
G
T
T
G
T
L
M
G
T
G
R
F
L
R
--
E
H
--
V
-
A
N
V
K
I
V
A
A
E
P
-----
R
Y
G
E
G
------
V
Y
A
--------------
L
R
N
M
D
E
G
F
V
P
E
L
Y
D
P
E
I
L
T
A
R
Y
S
V
G
A
V
D
A
V
R
R
T
R
E
L
V
H
T
E
G
I
F
A
G
I
S
T
G
A
V
L
H
A
A
L
G
-
V
G
A
-
G
A
L
A
A
G
E
-
R
A
D
-
I
A
L
V
V
A
D
A
G
W
K
Y
L
S
T
G
A
Y
A
G
--