@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu28150: (2016-07-14 )
MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKGDRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPEREDPRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLETEDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQFTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKETVTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK
Atome Classification :
(20 SA)
.........10........20........30..----......40........50........60......-----..70........--------------80........90...--.....100.......110---.---......120.......130........-------140..-.----....150......-.160........170.......180........190.......200.......210.......220.......230.......240.......250.-.......260.......270......------------------------------.-------------280.......------------------290.......300.......310..-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
M
R
T
I
KVGSRRS
K
L
A
M
T
Q
T
K
W
V
I
Q
K
L
K
EINP
S
F
----
A
F
E
I
K
E
I
VTKG
D
R
I
V
D
V
T
LSKVGGKG
L
F
V
K
E
I
E
Q
-----
A
L
L
N
E
E
I
D
M
A
V
H
--------------
S
M
KDM
P
A
VLPE
G
L
V
I
--
G
C
IPERED
P
R
D
A
LISKNR---
V
---
K
L
S
E
MKKG
A
V
I
G
T
S
S
L
R
R
-
S
A
Q
L
L
I
ER-------P
D
L
T
I
-
K
----
W
IRGN
I
D
T
R
L
Q
K
L-ET-EDY
D
A
I
I
L
A
AAGLSRMGW
K
Q
-
D
V
V
T
E
FL
E
P
E
R
CLPAVGQ
G
A
L
A
I
E
CRES
D
E
E
L
L
A
L
F
S
Q
F
T
D
E
Y
T
K
R
T
V
L
A
E
R
A
F
L
N
A
MEGGCQVPIA
G
Y
S-VL-NGQD
E
I
E
M
T
G
L
V
ASPD
G
K
I
I
F
K
ETVT------------------------------G-------------N
D
P
E
E
V
G
K
R
C
------------------
A
A
L
MADK
G
A
K
D
L
I
D
R
V
K
R
E
LDEDGK-
1
PsiBlast_PDB
86.05
70%
-46
- C4 -
4MLQ
2
?
A:
[3-310]
-
M
R
K
I
I
V
G
S
R
R
S
K
L
A
L
T
Q
T
K
W
V
I
E
Q
L
K
K
Q
G
L
P
F
----
E
F
E
I
K
E
M
V
---------------------
K
E
I
E
Q
-----
A
M
L
D
K
E
I
D
M
A
V
H
--------------
S
M
K
D
M
P
A
V
L
P
E
G
L
T
I
--
G
C
I
P
L
R
E
D
H
R
D
A
L
I
S
K
N
G
---
E
---
R
F
E
E
L
P
S
G
A
V
I
G
T
S
S
L
R
R
-
G
A
Q
L
L
S
M
R
-------
S
D
I
E
I
-
K
----
W
I
R
G
N
I
D
T
R
L
E
K
L
-
K
N
-
E
D
Y
D
A
I
I
L
A
A
A
G
L
S
R
M
G
W
S
K
-
D
T
V
T
Q
Y
L
E
P
E
I
S
V
P
A
V
G
Q
G
A
L
A
I
E
C
R
E
N
D
H
E
L
L
S
L
L
Q
A
L
N
H
D
E
T
A
R
A
V
R
A
E
R
V
F
L
K
E
M
E
G
G
C
Q
V
P
I
A
G
Y
G
R
I
L
-
D
G
G
N
-
I
E
L
T
S
L
V
A
S
P
D
G
K
T
I
Y
K
E
H
I
T
------------------------------
G
-------------
K
D
P
I
A
I
G
S
E
A
------------------
A
E
R
L
T
S
Q
G
A
K
L
L
I
D
R
V
K
E
E
L
------
2
PsiBlast_PDB
85.95
70%
-44
- C4 -
4MLV
2
?
A:
[3-311]
-
M
R
K
I
I
V
G
S
R
R
S
K
L
A
L
T
Q
T
K
W
V
I
E
Q
L
K
K
Q
G
L
P
F
----
E
F
E
I
K
E
M
V
---------------------
K
E
I
E
Q
-----
A
M
L
D
K
E
I
D
M
A
V
H
--------------
S
M
K
D
M
P
A
V
L
P
E
G
L
T
I
--
G
C
I
P
L
R
E
D
H
R
D
A
L
I
S
K
N
G
---
E
---
R
F
E
E
L
P
S
G
A
V
I
G
T
S
S
L
R
R
-
G
A
Q
L
L
S
M
R
-------
S
D
I
E
I
-
K
----
W
I
R
G
N
I
D
T
R
L
E
K
L
-
K
N
-
E
D
Y
D
A
I
I
L
A
A
A
G
L
S
R
M
G
W
S
K
-
D
T
V
T
Q
Y
L
E
P
E
I
S
V
P
A
V
G
Q
G
A
L
A
I
E
C
R
E
N
D
H
E
L
L
S
L
L
Q
A
L
N
H
D
E
T
A
R
A
V
R
A
E
R
V
F
L
K
E
M
E
G
G
C
Q
V
P
I
A
G
Y
G
R
I
L
-
D
G
G
N
-
I
E
L
T
S
L
V
A
S
P
D
G
K
T
I
Y
K
E
H
I
T
------------------------------
G
-------------
K
D
P
I
A
I
G
S
E
A
------------------
A
E
R
L
T
S
Q
G
A
K
L
L
I
D
R
V
K
E
E
L
D
-----
14
HHSearch
85.16
70%
-29
- C4 -
4MLV
2
?
A:
[2-311]
H
M
R
K
I
I
V
G
S
R
R
S
K
L
A
L
T
Q
T
K
W
V
I
E
Q
L
K
K
Q
G
L
P
F
----
E
F
E
I
K
E
M
V
---------------------
K
E
I
E
Q
-----
A
M
L
D
K
E
I
D
M
A
V
H
--------------
S
M
K
D
M
P
A
V
L
P
E
G
L
T
I
--
G
C
I
P
L
R
E
D
H
R
D
A
L
I
S
K
N
G
---
E
---
R
F
E
E
L
P
S
G
A
V
I
G
T
S
S
L
R
R
-
G
A
Q
L
L
S
M
R
-------
S
D
I
E
I
-
K
----
W
I
R
G
N
I
D
T
R
L
E
K
L
-
K
N
-
E
D
Y
D
A
I
I
L
A
A
A
G
L
S
R
M
G
W
S
K
D
T
V
T
Q
-
Y
L
E
P
E
I
S
V
P
A
V
G
Q
G
A
L
A
I
E
C
R
E
N
D
H
E
L
L
S
L
L
Q
A
L
N
H
D
E
T
A
R
A
V
R
A
E
R
V
F
L
K
E
M
E
G
G
C
Q
V
P
I
A
G
Y
G
-
R
I
-
L
D
G
G
N
I
E
L
T
S
L
V
A
S
P
D
G
K
T
I
Y
K
E
H
I
T
------------------------------
G
-------------
K
D
P
I
A
I
G
S
E
A
------------------
A
E
R
L
T
S
Q
G
A
K
L
L
I
D
R
V
K
E
E
L
D
-----
15
HHSearch
76.43
46%
-53
- C4 -
1GTK
1
HEM3_ECOLI
A:
[3-309]
-
D
N
V
L
R
I
A
T
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
G
L
----
V
V
E
L
V
P
M
V
-----------------
G
L
F
V
K
E
L
E
V
-----
A
L
L
E
N
R
A
D
I
A
V
H
--------------
S
M
K
D
V
P
V
E
F
P
Q
G
L
G
L
--
V
T
I
C
E
R
E
D
P
R
D
A
F
V
S
N
N
Y
---
D
---
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
R
R
-
Q
C
Q
L
A
E
R
R
-------
P
D
L
I
I
-
R
----
S
L
R
G
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
A
V
A
G
L
K
R
L
G
L
E
S
-
R
I
R
A
-
A
L
P
P
E
I
S
L
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
L
N
H
H
E
T
A
L
R
V
T
A
E
R
A
M
N
T
R
L
E
G
G
C
Q
V
P
I
G
S
Y
A
-
E
L
-
I
D
-
G
E
I
W
L
R
A
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
R
R
------------------------------
G
A
P-----------
Q
D
A
E
Q
M
G
I
S
L
------------------
A
E
E
L
L
N
N
G
A
R
E
I
L
A
E
V
Y
N
G
-------
5
PsiBlast_PDB
76.36
45%
-55
- C4 -
1PDA
2
HEM3_ECOLI
A:
[5-306]
---
V
L
R
I
A
T
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
G
L
----
V
V
E
L
V
P
M
V
T
R
G
D
V
I
---------
G
K
G
L
F
V
K
E
L
E
V
-----
A
L
L
E
N
R
A
D
I
A
V
H
--------------
S
M
K
D
V
P
V
E
F
P
Q
G
L
G
L
--
V
T
I
C
E
R
E
D
P
R
D
A
F
V
S
N
N
Y
---
D
---
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
R
R
-
Q
C
Q
L
A
E
R
R
-------
P
D
L
I
I
-
R
----
S
L
R
G
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
A
V
A
G
L
K
R
L
G
L
E
S
-
R
-
I
R
A
A
L
P
P
E
I
S
L
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
L
N
H
H
E
T
A
L
R
V
T
A
E
R
A
M
N
T
R
L
E
G
A
C
Q
V
P
I
G
S
Y
A
E
L
I
-
D
G
--
E
I
W
L
R
G
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
R
R
------------------------------
G
A
P-----------
Q
D
A
E
Q
M
G
I
S
L
------------------
A
E
E
L
L
N
N
G
A
R
E
I
L
A
E
V
----------
8
PsiBlast_PDB
75.95
45%
-57
- C4 -
1AH5
1
HEM3_ECOLI
A:
[5-306]
---
V
L
R
I
A
T
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
G
L
----
V
V
E
L
V
P
M
V
T
R
G
D
------------
K
G
L
F
V
K
E
L
E
V
-----
A
L
L
E
N
R
A
D
I
A
V
H
--------------
S
M
K
D
V
P
V
E
F
P
Q
G
L
G
L
--
V
T
I
C
E
R
E
D
P
R
D
A
F
V
S
N
N
Y
---
D
---
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
R
R
-
Q
C
Q
L
A
E
R
R
-------
P
D
L
I
I
-
R
----
S
L
R
G
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
A
V
A
G
L
K
R
L
G
L
E
S
-
R
-
I
R
A
A
L
P
P
E
I
S
L
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
L
N
H
H
E
T
A
L
R
V
T
A
E
R
A
M
N
T
R
L
E
G
G
C
Q
V
P
I
G
S
Y
A
E
L
I
-
D
G
--
E
I
W
L
R
A
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
R
R
------------------------------
G
A
P-----------
Q
D
A
E
Q
M
G
I
S
L
------------------
A
E
E
L
L
N
N
G
A
R
E
I
L
A
E
V
----------
4
PsiBlast_PDB
75.76
45%
-61
- C4 -
1GTK
1
HEM3_ECOLI
A:
[5-306]
---
V
L
R
I
A
T
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
G
L
----
V
V
E
L
V
P
M
V
-----------------
G
L
F
V
K
E
L
E
V
-----
A
L
L
E
N
R
A
D
I
A
V
H
--------------
S
M
K
D
V
P
V
E
F
P
Q
G
L
G
L
--
V
T
I
C
E
R
E
D
P
R
D
A
F
V
S
N
N
Y
---
D
---
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
R
R
-
Q
C
Q
L
A
E
R
R
-------
P
D
L
I
I
-
R
----
S
L
R
G
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
A
V
A
G
L
K
R
L
G
L
E
S
-
R
-
I
R
A
A
L
P
P
E
I
S
L
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
L
N
H
H
E
T
A
L
R
V
T
A
E
R
A
M
N
T
R
L
E
G
G
C
Q
V
P
I
G
S
Y
A
E
L
I
-
D
G
--
E
I
W
L
R
A
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
R
R
------------------------------
G
A
P-----------
Q
D
A
E
Q
M
G
I
S
L
------------------
A
E
E
L
L
N
N
G
A
R
E
I
L
A
E
V
----------
6
PsiBlast_PDB
74.43
45%
-53
- C4 -
1YPN
1
HEM3_ECOLI
A:
[5-306]
---
V
L
R
I
A
T
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
G
L
----
V
V
E
L
V
P
M
V
T
R
G
D
V
----------
G
Q
G
L
F
V
K
E
L
E
V
-----
A
L
L
E
N
R
A
D
I
A
V
H
--------------
S
M
K
D
V
P
V
E
F
P
Q
G
L
G
L
--
V
T
I
C
E
R
E
D
P
R
D
A
F
V
S
N
N
Y
---
D
---
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
R
R
-
Q
C
Q
L
A
E
R
R
-------
P
D
L
I
I
-
R
----
S
L
R
G
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
A
V
A
G
L
K
R
L
G
L
E
S
-
R
-
I
R
A
A
L
P
P
E
I
S
L
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
L
N
H
H
E
T
A
L
R
V
T
A
E
R
A
M
N
T
R
L
E
G
G
C
Q
V
P
I
G
S
Y
A
E
L
I
-
D
G
--
E
I
W
L
R
A
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
R
R
------------------------------
G
A
P-----------
Q
D
A
E
Q
M
G
I
S
L
------------------
A
E
E
L
L
N
N
G
A
R
E
I
L
A
E
V
----------
3
PsiBlast_PDB
73.83
45%
-61
- C4 -
2YPN
1
HEM3_ECOLI
A:
[5-306]
---
V
L
R
I
A
T
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
G
L
----
V
V
E
L
V
P
M
V
-----------------
G
L
F
V
K
E
L
E
V
-----
A
L
L
E
N
R
A
D
I
A
V
H
--------------
S
M
K
D
V
P
V
E
F
P
Q
G
L
G
L
--
V
T
I
C
E
R
E
D
P
R
D
A
F
V
S
N
N
Y
---
D
---
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
R
R
-
Q
C
Q
L
A
E
R
R
-------
P
D
L
I
I
-
R
----
S
L
R
G
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
A
V
A
G
L
K
R
L
G
L
E
S
-
R
-
I
R
A
A
L
P
P
E
I
S
L
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
L
N
H
H
E
T
A
L
R
V
T
A
E
R
A
M
N
T
R
L
E
G
G
C
Q
V
P
I
G
S
Y
A
E
L
I
-
D
G
--
E
I
W
L
R
A
L
V
G
A
P
D
G
S
Q
I
I
R
G
E
R
R
------------------------------
G
A
P-----------
Q
D
A
E
Q
M
G
I
S
L
------------------
A
E
E
L
L
N
N
G
A
R
E
I
L
A
E
V
----------
17
HHSearch
73.49
45%
2
- C4 -
3ECR
1
HEM3_HUMAN
A:
[21-359]
-
M
R
V
I
R
V
G
T
R
K
S
Q
L
A
R
I
Q
T
D
S
V
V
A
T
L
K
A
S
Y
P
G
L
----
Q
F
E
I
I
A
M
-------------------
L
F
T
K
E
L
E
H
-----
A
L
E
K
N
E
V
D
L
V
V
H
--------------
S
L
K
D
L
P
T
V
L
P
P
G
F
T
I
--
G
A
I
C
K
R
E
N
P
H
D
A
V
V
F
H
P
K
FVG
K
---
T
L
E
T
L
P
E
K
S
V
V
G
T
S
S
L
R
R
-
A
A
Q
L
Q
R
K
F
-------
P
H
L
E
F
-
R
----
S
I
R
G
N
L
N
T
R
L
R
K
L
-
D
E
Q
Q
E
F
S
A
I
I
L
A
T
A
G
L
Q
R
M
G
W
H
N
-
R
V
G
Q
-
I
L
H
P
E
E
C
M
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
L
H
D
P
E
T
L
L
R
C
I
A
E
R
A
F
L
R
H
L
E
--
C
S
V
P
V
A
V
H
T
-
A
M
-
K
D
-
G
Q
L
Y
L
T
G
G
V
W
S
L
D
G
S
D
S
I
Q
E
T
M
Q
A
T
I
H
VPAQHEDGPEDDPQLVGITARNIP
R
G
P
Q
------------
L
A
A
Q
N
L
G
I
S
L
------------------
A
N
L
L
L
S
K
G
A
K
N
I
L
D
V
A
R
Q
--------
13
PsiBlast_CBE
70.64
42%
3
- C4 -
3EQ1
5
HEM3_HUMAN
B:
[19-356]
--
R
V
I
R
V
G
T
R
K
S
Q
L
A
R
I
Q
T
D
S
V
V
A
T
L
K
A
S
Y
P
G
L
----
Q
F
E
I
I
A
---------------------
F
T
K
E
L
E
H
-----
A
L
E
K
N
E
V
D
L
V
V
H
--------------
S
L
K
D
L
P
T
V
L
P
P
G
F
T
I
--
G
A
I
C
K
R
E
N
P
H
D
A
V
V
F
H
P
K
---
F
VGK
T
L
E
T
L
P
E
K
S
V
V
G
T
S
S
L
R
R
-
A
A
Q
L
Q
R
K
F
-------
P
H
L
E
F
-
R
----
S
I
Q
G
N
L
N
T
R
L
R
K
L
D
E
Q
-
Q
E
F
S
A
I
I
L
A
T
A
G
L
Q
R
M
G
W
-
H
-
N
R
V
G
Q
I
L
H
P
E
E
C
M
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
L
H
D
P
E
T
L
L
R
C
I
A
E
R
A
F
L
R
H
L
E
G
G
C
S
V
P
V
A
V
H
T
-
A
M
K
D
G
Q
--
L
Y
L
T
G
G
V
W
S
L
D
G
S
D
S
I
Q
E
T
M
Q
------------------------------
A
TIHVPQHE-----
D
D
P
Q
L
V
G
I
T
A
RNIPRGPQLAAQNLGISL
A
N
L
L
L
S
K
G
A
K
N
I
L
D
-
V
A
R
Q
-------
9
PsiBlast_PDB
70.46
42%
3
- C4 -
3EQ1
4
HEM3_HUMAN
A:
[19-356]
--
R
V
I
R
V
G
T
R
K
S
Q
L
A
R
I
Q
T
D
S
V
V
A
T
L
K
A
S
Y
P
G
L
----
Q
F
E
I
I
A
---------------------
F
T
K
E
L
E
H
-----
A
L
E
K
N
E
V
D
L
V
V
H
--------------
S
L
K
D
L
P
T
V
L
P
P
G
F
T
I
--
G
A
I
C
K
R
E
N
P
H
D
A
V
V
F
H
P
K
---
F
VGK
T
L
E
T
L
P
E
K
S
V
V
G
T
S
S
L
R
R
-
A
A
Q
L
Q
R
K
F
-------
P
H
L
E
F
-
R
----
S
I
Q
G
N
L
N
T
R
L
R
K
L
D
E
Q
-
Q
E
F
S
A
I
I
L
A
T
A
G
L
Q
R
M
G
W
-
H
-
N
R
V
G
Q
I
L
H
P
E
E
C
M
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
L
H
D
P
E
T
L
L
R
C
I
A
E
R
A
F
L
R
H
L
E
G
G
C
S
V
P
V
A
V
H
T
-
A
M
K
D
G
Q
--
L
Y
L
T
G
G
V
W
S
L
D
G
S
D
S
I
Q
E
T
M
Q
------------------------------
A
TIHVPQHE-----
D
D
P
Q
L
V
G
I
T
A
RNIPR
G
P
Q
L
A
A
Q
N
L
G
I
S
L
A
N
L
L
L
S
K
G
A
K
N
I
L
D
-
V
A
R
Q
-------
7
PsiBlast_PDB
70.04
42%
-6
- C4 -
3ECR
1
HEM3_HUMAN
A:
[21-359]
-
M
R
V
I
R
V
G
T
R
K
S
Q
L
A
R
I
Q
T
D
S
V
V
A
T
L
K
A
S
Y
P
G
L
----
Q
F
E
I
I
A
M
-------------------
L
F
T
K
E
L
E
H
-----
A
L
E
K
N
E
V
D
L
V
V
H
--------------
S
L
K
D
L
P
T
V
L
P
P
G
F
T
I
--
G
A
I
C
K
R
E
N
P
H
D
A
V
V
F
H
P
K
---
F
VGK
T
L
E
T
L
P
E
K
S
V
V
G
T
S
S
L
R
R
-
A
A
Q
L
Q
R
K
F
-------
P
H
L
E
F
-
R
----
S
I
R
G
N
L
N
T
R
L
R
K
L
D
E
Q
-
Q
E
F
S
A
I
I
L
A
T
A
G
L
Q
R
M
G
W
-
H
-
N
R
V
G
Q
I
L
H
P
E
E
C
M
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
L
H
D
P
E
T
L
L
R
C
I
A
E
R
A
F
L
R
H
L
E
--
C
S
V
P
V
A
V
H
T
-
A
M
K
D
G
Q
--
L
Y
L
T
G
G
V
W
S
L
D
G
S
D
S
I
Q
E
T
M
Q
------------------------------
A
T
I
H
VPAQHEDGPE
D
D
P
Q
L
V
G
I
T
A
RNIP
R
G
P
Q
L
A
A
Q
N
L
G
I
S
L
A
N
L
L
L
S
K
G
A
K
N
I
L
D
-
V
A
R
Q
-------
12
PsiBlast_CBE
68.82
42%
-3
- C4 -
3ECR
1
HEM3_HUMAN
B:
[22-358]
--
R
V
I
R
V
G
T
R
K
S
Q
L
A
R
I
Q
T
D
S
V
V
A
T
L
K
A
S
Y
P
G
L
----
Q
F
E
I
I
A
M
-------------
K
I
G
E
K
S
L
F
T
K
E
L
E
H
-----
A
L
E
K
N
E
V
D
L
V
V
H
--------------
S
L
K
D
L
P
T
V
L
P
P
G
F
T
I
--
G
A
I
C
K
R
E
N
P
H
D
A
V
V
F
H
P
K
---
F
VGK
T
L
E
T
L
P
E
K
S
V
V
G
T
S
S
L
R
R
-
A
A
Q
L
Q
R
K
F
-------
P
H
L
E
F
-
R
----
S
I
R
G
N
L
N
T
R
L
R
K
L
D
E
Q
-
Q
E
F
S
A
I
I
L
A
T
A
G
L
Q
R
M
G
W
-
H
-
N
R
V
G
Q
I
L
H
P
E
E
C
M
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
L
H
D
P
E
T
L
L
R
C
I
A
E
R
A
F
L
R
H
L
E
--
C
S
V
P
V
A
V
H
T
-
A
M
K
D
G
Q
--
L
Y
L
T
G
G
V
W
S
L
D
G
S
D
S
I
Q
E
T
M
Q
------------------------------
A
TIH------------
P
Q
L
V
G
I
T
A
RNIP
R
G
P
Q
L
A
A
Q
N
L
G
I
S
L
A
N
L
L
L
S
K
G
A
K
N
I
L
D
-
V
A
R
--------
16
HHSearch
64.31
40%
46
- C4 -
4HTG
2
HEM3_ARATH
A:
[10-311]
-
T
A
I
I
R
I
G
T
R
G
S
P
L
A
L
A
Q
A
Y
E
T
R
E
K
L
K
K
K
H
P
E
L
VEDG
A
I
H
I
E
I
I
K
T
T
G
D
K
I
L
S
Q
P
L
A
D
I
G
G
K
G
L
F
T
K
E
I
D
E
-----
A
L
I
N
G
H
I
D
I
A
V
H
--------------
S
M
K
D
V
P
T
Y
L
P
E
K
T
I
L
--
P
C
N
L
P
R
E
D
V
R
D
A
F
I
C
L
T
A
---
A
---
T
L
A
E
L
P
A
G
S
V
V
G
T
A
S
L
R
R
-
K
S
Q
I
L
H
K
Y
-------
P
A
L
H
V
E
E
----
N
F
R
G
N
V
Q
T
R
L
S
K
L
-
Q
G
-
G
K
V
Q
A
T
L
L
A
L
A
G
L
K
R
L
S
M
T
E
-
N
V
A
S
-
I
L
S
L
D
E
M
L
P
A
V
A
Q
G
A
I
G
I
A
C
R
T
D
D
D
K
M
A
T
Y
L
A
S
L
N
H
E
E
T
R
L
A
I
S
C
E
R
A
F
L
E
T
L
D
G
S
C
R
T
P
I
A
G
Y
A
-
S
K
-
D
E
E
G
N
C
I
F
R
G
L
V
A
S
P
D
G
T
K
V
L
E
T
S
R
K
------------------------------
G
PYV
Y
---------
E
D
M
V
K
M
G
K
D
A
------------------
G
Q
E
L
L
S
--------------------
34
Fugue
61.38
49%
-71
- C4 -
1PDA
2
?
?:
[3-219]
-
D
N
V
L
R
I
A
T
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
G
L
----
V
V
E
L
V
P
M
V
T
R
G
D
V
---------
I
G
K
G
L
F
V
K
E
L
E
V
-----
A
L
L
E
N
R
A
D
I
A
V
H
--------------
S
M
K
D
V
P
V
E
F
P
Q
G
L
G
L
--
V
T
I
C
E
R
E
D
P
R
D
A
F
V
S
N
N
Y
---
D
---
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
R
R
-
Q
C
Q
L
A
E
R
R
-------
P
D
L
I
I
-
R
----
S
L
R
G
N
V
G
T
R
L
S
K
L
-
D
N
-
G
E
Y
D
A
I
I
L
A
V
A
G
L
K
R
L
G
L
E
S
-
R
I
-
R
A
A
L
P
P
E
I
S
L
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
61.16
41%
49
- C4 -
4HTG
2
HEM3_ARATH
A:
[13-291]
----
I
R
I
G
T
R
G
S
P
L
A
L
A
Q
A
Y
E
T
R
E
K
L
K
K
K
H
P
E
L
VEDG
A
I
H
I
E
I
I
K
T
T
G
D
K
I
L
S
Q
P
L
A
D
I
G
G
K
G
L
F
T
K
E
I
D
E
-----
A
L
I
N
G
H
I
D
I
A
V
H
--------------
S
M
K
D
V
P
T
Y
L
P
E
K
T
I
L
--
P
C
N
L
P
R
E
D
V
R
D
A
F
I
C
L
T
A
---
A
---
T
L
A
E
L
P
A
G
S
V
V
G
T
A
S
L
R
R
-
K
S
Q
I
L
H
K
Y
-------
P
A
L
H
V
E
E
----
N
F
R
G
N
V
Q
T
R
L
S
K
L
-
Q
G
-
G
K
V
Q
A
T
L
L
A
L
A
G
L
K
R
L
S
M
T
E
-
N
V
A
S
-
I
L
S
L
D
E
M
L
P
A
V
A
Q
G
A
I
G
I
A
C
R
T
D
D
D
K
M
A
T
Y
L
A
S
L
N
H
E
E
T
R
L
A
I
S
C
E
R
A
F
L
E
T
L
D
G
S
C
R
T
P
I
A
G
Y
A
-
S
K
-
D
E
E
G
N
C
I
F
R
G
L
V
A
S
P
D
G
T
K
V
L
E
T
S
R
K
------------------------------
G
-------------------------------------------------------------------
11
PsiBlast_PDB
34.96
35%
-165
- C4 -
3I6V
1
?
A:
[38-73]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
K
R
-------
A
G
L
T
C
-
E
----
W
V
K
N
D
W
D
S
I
I
P
N
L
-
V
S
-
G
N
Y
D
T
I
I
---
A
G
M
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
33.04
15%
13
- C4 -
1US5
2
?
A:
[17-313]
A
Q
E
F
I
T
I
G
S
G
S
T
T
--------------
G
V
Y
F
P
V
----
A
T
G
I
A
K
L
V
N
D
A
N
V
G
I
R
A
N
A
R
S
T
G
G
S
V
A
N
I
N
A
I
N
A
GEFE
M
A
L
A
Q
N
D
I
A
Y
Y
A
Y
Q
GCCIPAFEGKPVK
T
I
R
A
L
A
A
L
Y
P
E
V
V
H
V
--
V
A
R
K
D
A
G
I
R
T
V
A
D
L
K
G
K
R
---
V
---
V
V
G
D
V
G
-------
S
G
T
E
Q
-
N
A
R
Q
I
L
E
A
-------
Y
G
L
T
F
-
D
DLGQ
A
I
R
V
S
A
S
Q
G
I
Q
L
M
-
Q
D
-
K
R
A
D
A
L
F
Y
T
V
------
G
L
G
A
-
S
A
I
Q
Q
L
A
L
T
T
P
-----------
I
A
L
V
A
V
D
L
N
R
I
Q
A
I
A
K
K
Y
P
F
Y
V
G
F
N
I
P
G
G
T
Y
K
G
V
D
V
T
T
P
T
V
A
V
Q
A
M
L
I
-
A
S
-
E
R
L
S
E
E
T
V
Y
K
F
M
K
A
V
F
G
N
---
L
E
A
F
K
------------------------------
K
-------------
I
H
P
N
L
E
R
F
F
G
------------------
L
E
K
A
V
K
G
L
P
I
P
L
H
P
G
A
E
R
F
Y
K
E
A
G
V
L
22
HHSearch
27.03
14%
-4
- C4 -
2X26
1
SSUA_ECOLI
A:
[2-164]
-
P
E
A
L
R
I
G
Y
Q
K
G
S
I
G
M
V
L
A
K
-
S
H
Q
L
L
E
K
R
Y
P
E
S
----
K
I
S
W
V
E
F
P
A
-
G
------------------
P
Q
M
L
E
-----
A
L
N
V
G
S
I
D
L
G
S
T
--------------
G
D
I
P
P
I
F
A
Q
A
A
G
A
D
L
VY
V
G
V
E
P
P
K
P
K
A
E
V
I
L
V
A
E
N
SPI
K
---
T
V
A
D
L
K
-
G
H
K
V
A
F
Q
K
G
S
S
S
H
N
L
L
L
R
A
L
R
Q
A
GLKF
T
D
I
Q
P
-------
T
Y
L
T
P
A
D
A
R
A
A
F
-
Q
Q
-
G
N
V
D
A
W
A
I
W
D
P
Y
Y
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------