@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu28540: (2016-07-15 )
MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDAGVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIHGAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIGSGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVYSYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE
Atome Classification :
(25 SA)
.......-..10-.........20-.-.......30........40........50....-....60........----70...--....------.80.....--..----------.90..-.---.....100.......110.......120.......130.......140...----....150....-...160.......170.....--..180.......190.......200...-....210...-.---...-220...----....230.......240.......250......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
A
I
S
L
A
-
V
D
Q
--
F
V
A
V
L
T
IHNP
P
-
A
-
N
A
L
S
S
R
I
L
E
E
L
S
S
C
L
D
Q
C
ETDAG
V
R
S
I
I
I
HGEG-
R
F
FSAGA
D
I
K
E
F
T
S----LKGNE--
D
S
S
L
------
L
A
E
R
G
Q
Q
L
--
M
E
----------
R
I
E
SF-
P
---
K
P
I
I
A
A
I
H
G
A
ALGG
G
L
E
L
A
M
A
C
H
I
R
I
A
AEDAKLGLPELN
L
G
IIPGFAG
T
Q
R
----
L
P
R
Y
V
G
T
A
K
A
L
-
E
L
IGSGEPISG
K
E
A
L
D
L
G
L
V
S--IGAK
D
E
A
E
V
I
E
K
A
K
A
L
A
A
K
F
AEK
S
P
Q
T
L
-
A
S
L
L
E
L
L
YSN-K---VYS-YEG
S
L
K
----
L
E
A
K
RF
G
E
A
FE
S
E
D
A
K
E
G
I
Q
A
F
L
E
KRKPQFKGE
1
PsiBlast_PDB
86.55
53%
-106
- C2 -
3PEA
3
?
A:
[8-260]
---
L
S
V
R
-
V
E
D
--
H
I
A
V
A
T
L
N
H
A
P
-
A
-
N
A
M
S
S
Q
V
M
H
D
V
T
E
L
I
D
Q
V
E
K
D
D
N
I
R
V
V
V
I
H
G
E
G
-
R
F
F
S
A
G
A
D
I
K
E
F
T
S
----
V
T
E
A
K
--
Q
A
T
E
------
L
A
Q
L
G
Q
V
T
--
F
E
----------
R
V
E
K
C
-
S
---
K
P
V
I
A
A
I
H
G
A
A
L
G
G
G
L
E
F
A
M
S
C
H
M
R
F
A
T
E
S
A
K
L
G
L
P
E
L
T
L
G
L
I
P
G
F
A
G
T
Q
R
----
L
P
R
Y
V
G
K
A
K
A
C
-
E
M
M
L
T
S
T
P
I
T
G
A
E
A
L
K
W
G
L
V
N
---
G
V
F
A
E
E
T
F
L
D
D
T
L
K
V
A
K
Q
I
A
G
K
S
P
A
T
A
-
R
A
V
L
E
L
L
Q
T
T
-
K
---
S
S
H
-
Y
Y
E
G
V
Q
----
R
E
A
Q
I
F
G
E
V
F
T
S
E
D
G
R
E
G
V
A
A
F
L
E
K
R
K
P
S
F
S
G
-
124
HHSearch
86.45
54%
-105
- C2 -
3PEA
3
?
A:
[6-260]
-
K
F
L
S
V
R
-
V
E
D
--
H
I
A
V
A
T
L
N
H
A
P
-
A
-
N
A
M
S
S
Q
V
M
H
D
V
T
E
L
I
D
Q
V
E
K
D
D
N
I
R
V
V
V
I
H
G
E
G
-
R
F
F
S
A
G
A
D
I
K
E
F
T
S
----
V
T
E
A
K
--
Q
A
T
E
------
L
A
Q
L
G
Q
V
T
--
F
E
----------
R
V
E
K
C
-
S
---
K
P
V
I
A
A
I
H
G
A
A
L
G
G
G
L
E
F
A
M
S
C
H
M
R
F
A
T
E
S
A
K
L
G
L
P
E
L
T
L
G
L
I
P
G
F
A
G
T
Q
R
----
L
P
R
Y
V
G
K
A
K
A
C
-
E
M
M
L
T
S
T
P
I
T
G
A
E
A
L
K
W
G
L
V
N
--
G
V
-
F
A
E
E
T
F
L
D
D
T
L
K
V
A
K
Q
I
A
G
K
S
P
A
T
A
-
R
A
V
L
E
L
L
Q
T
T
-
K
---
S
S
H
-
Y
Y
E
G
V
Q
----
R
E
A
Q
I
F
G
E
V
F
T
S
E
D
G
R
E
G
V
A
A
F
L
E
K
R
K
P
S
F
S
G
-
132
HHSearch
71.61
37%
-13
- C2 -
2PBP
-
?
A:
[6-258]
--
S
I
A
A
R
-
Q
E
G
--
A
V
G
I
I
E
L
A
R
P
D
V
L
-
N
A
L
S
R
Q
M
V
A
E
I
V
A
A
V
E
A
F
D
R
N
E
K
V
R
V
I
V
L
T
G
R
G
-
R
A
F
A
A
G
A
D
I
Q
E
M
A
K
----
D
D
-
P
I
--
R
-
L
E
-------
W
L
N
Q
F
A
D
--
W
D
----------
R
L
S
I
V
-
K
---
T
P
M
I
A
A
V
N
G
L
A
L
G
G
G
F
E
L
A
L
S
C
D
L
I
V
A
S
S
A
A
E
F
G
F
P
E
V
N
L
G
V
M
P
G
A
G
G
T
Q
R
----
L
T
K
L
I
G
P
K
R
A
L
-
E
W
L
W
T
G
A
R
M
S
A
K
E
A
E
Q
L
G
I
V
N
--
R
V
-
V
S
P
E
L
L
M
E
E
T
M
R
L
A
G
R
L
A
E
Q
P
P
L
A
L
-
R
L
I
K
E
A
V
Q
K
A
-
V
---
D
Y
P
-
L
Y
E
G
M
Q
----
F
E
R
K
N
F
Y
L
L
F
A
S
E
D
Q
K
E
G
M
A
A
F
L
E
K
R
K
P
R
F
Q
G
K
127
HHSearch
71.38
39%
-24
- C2 -
4FZW
1
PAAF_ECOLI
A:
[5-257]
-
S
E
L
I
V
S
-
R
Q
Q
--
R
V
L
L
L
T
L
N
R
P
A
A
R
-
N
A
L
N
N
A
L
L
M
Q
L
V
N
E
L
E
A
A
A
T
D
T
S
I
S
V
C
V
I
T
G
N
A
-
R
F
F
A
A
G
A
D
L
N
E
M
A
E
----
K
D
-----
L
A
A
T
------
L
N
D
T
R
P
Q
L
--
W
A
----------
R
L
Q
A
F
-
N
---
K
P
L
I
A
A
V
N
G
Y
A
L
G
A
G
C
E
L
A
L
L
C
D
V
V
V
A
G
E
N
A
R
F
G
L
P
E
I
T
L
G
I
M
P
G
A
G
G
T
Q
R
----
L
I
R
S
V
G
K
S
L
A
S
-
K
M
V
L
S
G
E
S
I
T
A
Q
Q
A
Q
Q
A
G
L
V
S
--
D
V
-
F
P
S
D
L
T
L
E
Y
A
L
Q
L
A
S
K
M
A
R
H
S
P
L
A
L
-
Q
A
A
K
Q
A
L
R
Q
S
-
Q
---
E
V
A
-
L
Q
A
G
L
A
----
Q
E
R
Q
L
F
T
L
L
A
A
T
E
D
R
H
E
G
I
S
A
F
L
Q
K
R
T
P
D
F
K
G
-
21
PsiBlast_CBE
71.30
39%
-25
- C2 -
4FZW
2
PAAF_ECOLI
B:
[4-258]
M
S
E
L
I
V
S
-
R
Q
Q
--
R
V
L
L
L
T
L
N
R
P
A
-
A
R
N
A
L
N
N
A
L
L
M
Q
L
V
N
E
L
E
A
A
A
T
D
T
S
I
S
V
C
V
I
T
G
N
A
-
R
F
F
A
A
G
A
D
L
N
E
M
A
E
-------
K
D
--
L
A
A
T
------
L
N
D
T
R
P
Q
L
--
W
A
----------
R
L
Q
A
F
-
N
---
K
P
L
I
A
A
V
N
G
Y
A
L
G
A
G
C
E
L
A
L
L
C
D
V
V
V
A
G
E
N
A
R
F
G
L
P
E
I
T
L
G
I
M
P
G
A
G
G
T
Q
R
----
L
I
R
S
V
G
K
S
L
A
S
-
K
M
V
L
S
G
E
S
I
T
A
Q
Q
A
Q
Q
A
G
L
V
S
D-
V
F
P
S
D
--
L
T
L
E
Y
A
L
Q
L
A
S
K
M
A
R
H
S
P
L
A
L
-
Q
A
A
K
Q
A
L
R
Q
S
-
Q
---
E
V
A
-
L
Q
A
G
L
A
----
Q
E
R
Q
L
F
T
L
L
A
A
T
E
D
R
H
E
G
I
S
A
F
L
Q
K
R
T
P
D
F
K
G
R
2
PsiBlast_PDB
71.30
39%
-22
- C2 -
4FZW
1
PAAF_ECOLI
A:
[5-258]
-
S
E
L
I
V
S
-
R
Q
Q
--
R
V
L
L
L
T
L
N
R
P
A
-
A
R
N
A
L
N
N
A
L
L
M
Q
L
V
N
E
L
E
A
A
A
T
D
T
S
I
S
V
C
V
I
T
G
N
A
-
R
F
F
A
A
G
A
D
L
N
E
M
A
E
-------
K
D
--
L
A
A
T
------
L
N
D
T
R
P
Q
L
--
W
A
----------
R
L
Q
A
F
-
N
---
K
P
L
I
A
A
V
N
G
Y
A
L
G
A
G
C
E
L
A
L
L
C
D
V
V
V
A
G
E
N
A
R
F
G
L
P
E
I
T
L
G
I
M
P
G
A
G
G
T
Q
R
----
L
I
R
S
V
G
K
S
L
A
S
-
K
M
V
L
S
G
E
S
I
T
A
Q
Q
A
Q
Q
A
G
L
V
S
D-
V
F
P
S
D
--
L
T
L
E
Y
A
L
Q
L
A
S
K
M
A
R
H
S
P
L
A
L
-
Q
A
A
K
Q
A
L
R
Q
S
-
Q
---
E
V
A
-
L
Q
A
G
L
A
----
Q
E
R
Q
L
F
T
L
L
A
A
T
E
D
R
H
E
G
I
S
A
F
L
Q
K
R
T
P
D
F
K
G
R
3
PsiBlast_PDB
70.90
38%
4
- C2 -
2PBP
-
?
A:
[5-258]
---
V
S
I
A
-
A
R
Q
E
G
A
V
G
I
I
E
L
A
R
P
D
-
V
L
N
A
L
S
R
Q
M
V
A
E
I
V
A
A
V
E
A
F
D
R
N
E
K
V
R
V
I
V
L
T
G
R
G
-
R
A
F
A
A
G
A
D
I
Q
E
M
A
---------
K
--
D
D
P
I
------
R
L
E
W
L
N
Q
F
A
D
W
D
----------
R
L
S
I
V
-
K
---
T
P
M
I
A
A
V
N
G
L
A
L
G
G
G
F
E
L
A
L
S
C
D
L
I
V
A
S
S
A
A
E
F
G
F
P
E
V
N
L
G
V
M
P
G
A
G
G
T
Q
R
----
L
T
K
L
I
G
P
K
R
A
L
-
E
W
L
W
T
G
A
R
M
S
A
K
E
A
E
Q
L
G
I
V
N
--
R
V
V
S
P
E
L
-
L
M
E
E
T
M
R
L
A
G
R
L
A
E
Q
P
P
L
A
L
-
R
L
I
K
E
A
V
Q
K
A
-
V
---
D
Y
P
L
Y
E
G
-
M
Q
----
F
E
R
K
N
F
Y
L
L
F
A
S
E
D
Q
K
E
G
M
A
A
F
L
E
K
R
K
P
R
F
Q
G
K
73
PsiBlast_CBE
70.70
31%
-53
- C2 -
1DCI
9
ECH1_RAT
C:
[26-265]
---------------------------
N
A
M
N
R
A
F
W
R
E
L
V
E
C
F
Q
K
I
S
K
D
S
D
C
R
A
V
V
V
S
G
A
G
-
K
M
F
T
S
G
I
D
L
M
D
M
A
S
DILQ
P
P
G
D
D
--
V
A
R
I
AWYLRD
L
I
S
R
Y
Q
K
T
--
F
T
----------
V
I
E
K
C
-
P
---
K
P
V
I
A
A
I
H
G
G
C
I
G
G
G
V
D
L
I
S
A
C
D
I
R
Y
C
T
Q
D
A
F
F
Q
V
K
E
V
D
V
G
L
A
A
D
V
G
T
L
Q
R
----
L
P
K
V
I
G
N
R
S
L
V
N
E
L
T
F
T
A
R
K
M
M
A
D
E
A
L
D
S
G
L
V
S
--
R
V
F
P
D
K
D
V
M
L
N
A
A
F
A
L
A
A
D
I
S
S
K
S
P
V
A
V
Q
G
S
K
I
N
L
I
Y
S
R
-
D
----
H
S
-
V
D
E
S
L
D
----
Y
M
A
T
W
N
M
S
M
L
Q
T
Q
D
I
I
K
S
V
Q
A
A
M
E
K
K
-------
25
PsiBlast_CBE
70.60
38%
3
- C2 -
2QQ3
1
?
I:
[5-258]
---
V
S
I
A
-
A
R
Q
EG
A
V
G
I
I
E
L
A
R
P
D
-
V
L
N
A
L
S
R
Q
M
V
A
E
I
V
A
A
V
E
A
F
D
R
N
E
K
V
R
V
I
V
L
T
G
R
G
-
R
A
F
A
A
G
A
D
I
Q
E
M
A
---------
K
--
D
D
P
I
------
R
L
E
W
L
N
Q
F
AD
W
D
----------
R
L
S
I
V
-
K
---
T
P
M
I
A
A
V
N
G
L
A
L
G
G
G
F
E
L
A
L
S
C
D
L
I
V
A
S
S
A
A
E
F
G
F
P
E
V
N
L
G
V
M
P
G
A
G
G
T
Q
R
----
L
T
K
L
I
G
P
K
R
A
L
-
E
W
L
W
T
G
A
R
M
S
A
K
E
A
E
Q
L
G
I
V
N
--
R
V
V
S
P
E
L
-
L
M
E
E
T
M
R
L
A
G
R
L
A
E
Q
P
P
L
A
L
-
R
L
I
K
E
A
V
Q
K
A
-
V
---
D
Y
P
L
Y
E
G
-
M
Q
----
F
E
R
K
N
F
Y
L
L
F
A
S
E
D
Q
K
E
G
M
A
A
F
L
E
K
R
K
P
R
F
Q
G
K
16
PsiBlast_PDB
70.47
35%
-14
- C2 -
3MOY
5
?
A:
[20-260]
--------------
V
G
L
I
R
L
D
R
P
D
-
A
L
N
A
L
N
Q
T
L
E
A
E
V
L
D
A
A
R
D
F
D
A
D
L
E
I
G
A
I
V
V
T
G
S
E
-
R
A
F
A
A
G
A
D
I
A
E
M
V
T
----
L
T
P
H
Q
--------------
A
R
E
R
N
L
--
L
S
----------
G
W
D
S
L
-
T
Q
VR
K
P
I
V
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
L
C
D
L
V
I
A
A
D
T
A
R
F
G
Q
P
E
I
T
L
G
I
L
P
G
L
G
G
T
Q
R
----
L
T
R
A
V
G
K
A
K
A
M
-
D
L
C
L
T
G
R
S
L
T
A
E
E
A
E
R
V
G
L
V
S
---
R
I
V
P
A
A
D
L
L
D
E
A
L
A
V
A
Q
R
I
A
R
M
S
R
P
A
G
-
R
A
V
K
D
A
I
N
E
A
-
F
---
E
R
P
-
L
S
A
G
M
R
----
Y
E
R
D
A
F
Y
A
M
F
D
T
H
D
Q
T
E
G
M
T
A
F
L
E
K
R
T
P
E
F
---
133
HHSearch
70.11
37%
-21
* C2 *
3H81
5
ECHA8_MYCTU
A:
[26-277]
--
T
I
L
V
E
-
R
D
Q
--
R
V
G
I
I
T
L
N
R
P
Q
A
L
-
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
-
K
A
F
A
A
G
A
D
I
K
E
M
A
D
----
L
T
-----
F
A
D
A
------
F
T
A
D
F
F
A
T
--
W
G
----------
K
L
A
A
V
-
R
---
T
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
P
G
M
G
G
S
Q
R
----
L
T
R
A
I
G
K
A
K
A
M
-
D
L
I
L
T
G
R
T
M
D
A
A
E
A
E
R
S
G
L
V
S
--
R
V
-
V
P
A
D
D
L
L
T
E
A
R
A
T
A
T
T
I
S
Q
M
S
A
S
A
A
-
R
M
A
K
E
A
V
N
R
A
-
F
---
E
S
S
-
L
S
E
G
L
L
----
Y
E
R
R
L
F
H
S
A
F
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
A
P
Q
F
T
H
-
14
PsiBlast_PDB
70.05
38%
1
- C2 -
2HW5
-
ECHM_HUMAN
A:
[43-286]
--------------
V
G
L
I
Q
L
N
R
P
K
-
A
L
N
A
L
C
D
G
L
I
D
E
L
N
Q
A
L
K
I
F
E
E
D
P
A
V
G
A
I
V
L
T
G
G
D
-
K
A
F
A
A
G
A
D
I
K
E
M
Q
N
----
L
S
F
Q
D
-----
C
------
Y
S
S
K
F
L
K
H
--
W
D
----------
H
L
T
Q
V
-
K
---
K
P
V
I
A
A
V
N
G
Y
A
F
G
G
G
C
E
L
A
M
M
C
D
I
I
Y
A
G
E
K
A
Q
F
A
Q
P
E
I
L
I
G
T
I
P
G
A
G
G
T
Q
R
----
L
T
R
A
V
G
K
S
L
A
M
-
E
M
V
L
T
G
D
R
I
S
A
Q
D
A
K
Q
A
G
L
V
S
--
K
I
C
P
V
E
T
-
L
V
E
E
A
I
Q
C
A
E
K
I
A
S
N
S
K
I
V
V
-
A
M
A
K
E
S
V
N
A
A
F
E
---
M
T
L
-
T
E
G
S
-
K
----
L
E
K
K
L
F
Y
S
T
F
A
T
D
D
R
K
E
G
M
T
A
F
V
E
K
R
K
A
N
F
K
D
Q
39
PsiBlast_CBE
70.00
39%
-10
- C2 -
3Q0G
2
ECHA8_MYCTU
C:
[11-254]
---------
D
Q
--
R
V
G
I
I
T
L
N
R
P
Q
-
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
-
K
A
F
A
A
G
A
D
I
K
E
M
A
D
----
L
T
F
A
D
A
F
T
A
D
F
------
F
A
T
W
G
-----------------
K
L
A
A
V
-
R
---
T
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
P
G
M
G
G
S
Q
R
----
L
T
R
A
I
G
K
A
K
A
M
-
D
L
I
L
T
G
R
T
M
D
A
A
E
A
E
R
S
G
L
V
S
RV
V
P
A
D
D
---
L
L
T
E
A
R
A
T
A
T
T
I
S
Q
M
S
-----
A
S
A
A
R
M
A
K
E
A
-
V
---
N
R
A
-
F
E
S
S
L
S
E
G
L
L
Y
E
R
R
L
F
H
S
A
F
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
A
P
Q
F
---
54
PsiBlast_CBE
69.96
39%
-6
- C2 -
1DUB
1
ECHM_RAT
E:
[18-259]
--------------
V
G
L
I
Q
L
N
R
P
K
-
A
L
N
A
L
C
N
G
L
I
E
E
L
N
Q
A
L
E
T
F
E
E
D
P
A
V
G
A
I
V
L
T
G
G
E
-
K
A
F
A
A
G
A
D
I
K
E
-------
M
Q
N
R
T
--
F
Q
D
C
------
Y
S
G
K
F
L
S
H
--
W
D
----------
H
I
T
R
I
-
K
---
K
P
V
I
A
A
V
N
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
I
I
Y
A
G
E
K
A
Q
F
G
Q
P
E
I
L
L
G
T
I
P
G
A
G
G
T
Q
R
----
L
T
R
A
V
G
K
S
L
A
M
-
E
M
V
L
T
G
D
R
I
S
A
Q
D
A
K
Q
A
G
L
V
S
--
K
I
F
P
V
E
T
-
L
V
E
E
A
I
Q
C
A
E
K
I
A
N
N
S
K
I
I
V
-
A
M
A
K
E
S
V
N
A
A
-
F
---
E
M
T
-
L
T
E
G
N
K
----
L
E
K
K
L
F
Y
S
T
F
A
T
D
D
R
R
E
G
M
S
A
F
V
E
K
R
K
A
N
F
K
--
62
PsiBlast_CBE
69.95
39%
-7
- C2 -
1EY3
2
ECHM_RAT
B:
[15-256]
--------------
V
G
L
I
Q
L
N
R
P
K
-
A
L
N
A
L
C
N
G
L
I
E
E
L
N
Q
A
L
E
T
F
E
E
D
P
A
V
G
A
I
V
L
T
G
G
E
-
K
A
F
A
A
G
A
D
I
K
E
-------
M
Q
N
R
T
--
F
Q
D
C
------
Y
S
G
K
F
L
S
H
--
W
D
----------
H
I
T
R
I
-
K
---
K
P
V
I
A
A
V
N
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
I
I
Y
A
G
E
K
A
Q
F
G
Q
P
E
I
L
L
G
T
I
P
G
A
G
G
T
Q
R
----
L
T
R
A
V
G
K
S
L
A
M
-
E
M
V
L
T
G
D
R
I
S
A
Q
D
A
K
Q
A
G
L
V
S
--
K
I
F
P
V
E
T
-
L
V
E
E
A
I
Q
C
A
E
K
I
A
N
N
S
K
I
I
V
-
A
M
A
K
E
S
V
N
A
A
-
F
---
E
M
T
-
L
T
E
G
N
K
----
L
E
K
K
L
F
Y
S
T
F
A
T
D
D
R
R
E
G
M
S
A
F
V
E
K
R
K
A
N
F
K
--
32
PsiBlast_CBE
69.91
39%
-13
- C2 -
3Q0J
1
ECHA8_MYCTU
D:
[12-255]
---------
D
Q
--
R
V
G
I
I
T
L
N
R
P
Q
-
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
-
K
A
F
A
A
G
A
D
I
K
E
M
A
D
----
L
T
F
A
D
AF
T
A
D
F
------
F
A
T
W
G
-----------------
K
L
A
A
V
-
R
---
T
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
P
G
M
G
G
S
Q
R
----
L
T
R
A
I
G
K
A
K
A
M
-
D
L
I
L
T
G
R
T
M
D
A
A
E
A
E
R
S
G
L
V
S
RV
V
P
A
D
D
---
L
L
T
E
A
R
A
T
A
T
T
I
S
Q
M
S
-----
A
S
A
A
R
M
A
K
E
A
-
V
---
N
R
A
-
F
E
S
S
L
S
EGLL
Y
E
R
R
L
F
H
S
A
F
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
A
P
Q
F
---
57
PsiBlast_CBE
69.84
39%
-6
- C2 -
1DUB
2
ECHM_RAT
B:
[18-259]
--------------
V
G
L
I
Q
L
N
R
P
K
-
A
L
N
A
L
C
N
G
L
I
E
E
L
N
Q
A
L
E
T
F
E
E
D
P
A
V
G
A
I
V
L
T
G
G
E
-
K
A
F
A
A
G
A
D
I
K
E
-------
M
Q
N
R
T
--
F
Q
D
C
------
Y
S
G
K
F
L
S
H
--
W
D
----------
H
I
T
R
I
-
K
---
K
P
V
I
A
A
V
N
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
I
I
Y
A
G
E
K
A
Q
F
G
Q
P
E
I
L
L
G
T
I
P
G
A
G
G
T
Q
R
----
L
T
R
A
V
G
K
S
L
A
M
-
E
M
V
L
T
G
D
R
I
S
A
Q
D
A
K
Q
A
G
L
V
S
--
K
I
F
P
V
E
T
-
L
V
E
E
A
I
Q
C
A
E
K
I
A
N
N
S
K
I
I
V
-
A
M
A
K
E
S
V
N
A
A
-
F
---
E
M
T
-
L
T
E
G
N
K
----
L
E
K
K
L
F
Y
S
T
F
A
T
D
D
R
R
E
G
M
S
A
F
V
E
K
R
K
A
N
F
K
--
64
PsiBlast_CBE
69.77
38%
0
- C2 -
2HW5
3
ECHM_HUMAN
C:
[43-286]
--------------
V
G
L
I
Q
L
N
R
P
K
-
A
L
N
A
L
C
D
G
L
I
D
E
L
N
Q
A
L
K
I
F
E
E
D
P
A
V
G
A
I
V
L
T
G
G
D
-
K
A
F
A
A
G
A
D
I
K
E
M
Q
N
----
L
S
F
Q
D
-----
C
------
Y
S
S
K
F
L
K
H
--
W
D
----------
H
L
T
Q
V
-
K
---
K
P
V
I
A
A
V
N
G
Y
A
F
G
G
G
C
E
L
A
M
M
C
D
I
I
Y
A
G
E
K
A
Q
F
A
Q
P
E
I
L
I
G
T
I
P
G
A
G
G
T
Q
R
----
L
T
R
A
V
G
K
S
L
A
M
-
E
M
V
L
T
G
D
R
I
S
A
Q
D
A
K
Q
A
G
L
V
S
--
K
I
C
P
V
E
T
-
L
V
E
E
A
I
Q
C
A
E
K
I
A
S
N
S
K
I
V
V
-
A
M
A
K
E
S
V
N
A
A
F
E
---
M
T
L
-
T
E
G
S
-
K
----
L
E
K
K
L
F
Y
S
T
F
A
T
D
D
R
K
E
G
M
T
A
F
V
E
K
R
K
A
N
F
K
D
Q
59
PsiBlast_CBE
69.55
39%
-8
- C2 -
1EY3
2
ECHM_RAT
E:
[15-256]
--------------
V
G
L
I
Q
L
N
R
P
K
-
A
L
N
A
L
C
N
G
L
I
E
E
L
N
Q
A
L
E
T
F
E
E
D
P
A
V
G
A
I
V
L
T
G
G
E
-
K
A
F
A
A
G
A
D
I
K
E
-------
M
Q
N
R
T
--
F
Q
D
C
------
Y
S
G
K
F
L
S
H
--
W
D
----------
H
I
T
R
I
-
K
---
K
P
V
I
A
A
V
N
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
I
I
Y
A
G
E
K
A
Q
F
G
Q
P
E
I
L
L
G
T
I
P
G
A
G
G
T
Q
R
----
L
T
R
A
V
G
K
S
L
A
M
-
E
M
V
L
T
G
D
R
I
S
A
Q
D
A
K
Q
A
G
L
V
S
--
K
I
F
P
V
E
T
-
L
V
E
E
A
I
Q
C
A
E
K
I
A
N
N
S
K
I
I
V
-
A
M
A
K
E
S
V
N
A
A
-
F
---
E
M
T
-
L
T
E
G
N
K
----
L
E
K
K
L
F
Y
S
T
F
A
T
D
D
R
R
E
G
M
S
A
F
V
E
K
R
K
A
N
F
K
--
56
PsiBlast_CBE
69.51
39%
-4
- C2 -
1DUB
2
ECHM_RAT
C:
[18-259]
--------------
V
G
L
I
Q
L
N
R
P
K
-
A
L
N
A
L
C
N
G
L
I
E
E
L
N
Q
A
L
E
T
F
E
E
D
P
A
V
G
A
I
V
L
T
G
G
E
-
K
A
F
A
A
G
A
D
I
K
E
-------
M
Q
N
R
T
--
F
Q
D
C
------
Y
S
G
K
F
L
S
H
--
W
D
----------
H
I
T
R
I
-
K
---
K
P
V
I
A
A
V
N
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
I
I
Y
A
G
E
K
A
Q
F
G
Q
P
E
I
L
L
G
T
I
P
G
A
G
G
T
Q
R
----
L
T
R
A
V
G
K
S
L
A
M
-
E
M
V
L
T
G
D
R
I
S
A
Q
D
A
K
Q
A
G
L
V
S
--
K
I
F
P
V
E
T
-
L
V
E
E
A
I
Q
C
A
E
K
I
A
N
N
S
K
I
I
V
-
A
M
A
K
E
S
V
N
A
A
-
F
---
E
M
T
-
L
T
E
G
N
K
----
L
E
K
K
L
F
Y
S
T
F
A
T
D
D
R
R
E
G
M
S
A
F
V
E
K
R
K
A
N
F
K
--
6
PsiBlast_PDB
68.81
39%
-5
- C2 -
3H81
5
ECHA8_MYCTU
A:
[32-275]
---------
D
Q
--
R
V
G
I
I
T
L
N
R
P
Q
-
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
-
K
A
F
A
A
G
A
D
I
K
E
M
A
D
----
L
T
F
A
D
A
F
T
A
D
F
------
F
A
T
W
G
-----------------
K
L
A
A
V
-
R
---
T
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
P
G
M
G
G
S
Q
R
----
L
T
R
A
I
G
K
A
K
A
M
-
D
L
I
L
T
G
R
T
M
D
A
A
E
A
E
R
S
G
L
V
S
RV
V
P
A
D
D
---
L
L
T
E
A
R
A
T
A
T
T
I
S
Q
M
S
-----
A
S
A
A
R
M
A
K
E
A
-
V
---
N
R
A
-
F
E
S
S
L
S
E
G
L
L
Y
E
R
R
L
F
H
S
A
F
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
A
P
Q
F
---
34
PsiBlast_CBE
67.72
39%
-12
- C2 -
3H81
6
ECHA8_MYCTU
C:
[32-275]
---------
D
Q
--
R
V
G
I
I
T
L
N
R
P
Q
-
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
-
K
A
F
A
A
G
A
D
I
K
E
M
A
D
----
L
T
F
A
D
AF
T
A
D
F
------
F
A
T
W
G
-----------------
K
L
A
A
V
-
R
---
T
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
P
G
M
G
G
S
Q
R
----
L
T
R
A
I
G
K
A
K
A
M
-
D
L
I
L
T
G
R
T
M
D
A
A
E
A
E
R
S
G
L
V
S
RV
V
P
A
D
D
---
L
L
T
E
A
R
A
T
A
T
T
I
S
Q
M
S
-----
A
S
A
A
R
M
A
K
E
A
-
V
---
N
R
A
-
F
E
S
S
L
S
EGLL
Y
E
R
R
L
F
H
S
A
F
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
A
P
Q
F
---
135
HHSearch
67.42
34%
18
- C2 -
3MOY
6
?
A:
[11-262]
---
I
A
T
S
R
P
V
A
--
G
V
G
L
I
R
L
D
R
P
D
A
L
-
N
A
L
N
Q
T
L
E
A
E
V
L
D
A
A
R
D
F
D
A
D
L
E
I
G
A
I
V
V
T
G
S
E
-
R
A
F
A
A
G
A
D
I
A
E
M
V
T
----
L
T
-
P
H
----
Q
A
------
R
E
R
N
L
L
S
G
--
W
D
----------
S
L
T
Q
V
-
R
---
K
P
I
V
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
L
C
D
L
V
I
A
A
D
T
A
R
F
G
Q
P
E
I
T
L
G
I
L
P
G
L
G
G
T
Q
R
----
L
T
R
A
V
G
K
A
K
A
M
-
D
L
C
L
T
G
R
S
L
T
A
E
E
A
E
R
V
G
L
V
S
--
R
I
-
V
P
A
A
D
L
L
D
E
A
L
A
V
A
Q
R
I
A
R
M
S
R
P
A
G
-
R
A
V
K
D
A
I
N
E
A
-
F
---
E
R
P
-
L
S
A
G
M
R
----
Y
E
R
D
A
F
Y
A
M
F
D
T
H
D
Q
T
E
G
M
T
A
F
L
E
K
R
T
P
E
F
T
D
-
35
PsiBlast_CBE
67.07
39%
-14
- C2 -
3H81
4
ECHA8_MYCTU
B:
[32-275]
---------
D
Q
--
R
V
G
I
I
T
L
N
R
P
Q
-
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
-
K
A
F
A
A
G
A
D
I
K
E
M
A
D
----
L
T
F
A
D
AF
T
A
D
F
------
F
A
T
W
G
-----------------
K
L
A
A
V
-
R
---
T
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
P
G
M
G
G
S
Q
R
----
L
T
R
A
I
G
K
A
K
A
M
-
D
L
I
L
T
G
R
T
M
D
A
A
E
A
E
R
S
G
L
V
S
RV
V
P
A
D
D
---
L
L
T
E
A
R
A
T
A
T
T
I
S
Q
M
S
-----
A
S
A
A
R
M
A
K
E
A
-
V
---
N
R
A
-
F
E
S
S
L
S
EGLL
Y
E
R
R
L
F
H
S
A
F
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
A
P
Q
F
---
77
PsiBlast_CBE
64.62
35%
-6
- C2 -
3R0O
4
?
B:
[25-271]
--------------
V
A
L
I
T
I
D
R
P
D
-
A
R
N
A
V
N
G
A
V
S
T
A
V
G
D
A
L
E
E
A
Q
R
D
P
E
V
W
A
V
V
I
T
G
A
G
D
K
S
F
C
A
G
A
D
L
K
A
I
S
-------------------------
R
G
E
N
L
--
Y
H
AEHPEWGFAG
Y
V
H
H
F
I
D
---
K
P
T
I
A
A
V
N
G
T
A
L
G
G
G
S
E
L
A
L
A
S
D
L
V
I
A
C
E
S
A
S
F
G
L
P
E
V
K
R
G
L
I
A
G
A
G
G
V
F
R
I
V
E
Q
L
P
R
K
V
----
A
L
-
E
L
V
L
T
G
E
P
M
T
A
S
D
A
L
R
W
G
L
I
N
--
E
V
V
P
D
-
G
T
V
V
E
A
A
L
A
L
A
E
R
I
T
C
N
A
P
L
S
V
-
Q
A
S
K
R
V
A
Y
G
A
-
D
DGI
I
G
A
-
E
E
P
K
W
E
----
R
T
I
R
E
F
T
E
L
L
K
S
E
D
A
K
E
G
P
L
A
F
A
E
K
R
Q
P
V
W
K
--