@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu33970: (2016-07-27 )
MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTIRKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIESYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLEKNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKRMNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEIALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDCLEHKKPKQEDVIFEPELIIRQSARKLNE
Atome Classification :
(20 SA)
.........10........20........30........40........50.--.---......60........70.....-...80........90........100.......110.......120.......130.......140-----........150.......160........170....-...180....-...190.......200.......210..-....-...220.......230...-...--.--240.-.....--.250.......260--.---......270.......280.......290.......300.......310.......320.......330.......-340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLP
K
Y
A
Q
V
K
E
E
I
S
S
W
I
NQGKILPDQKIP
T
E
N
E
L
M
Q
Q
FGV
S
R
H
T
I
R
K
A
I
G
D
L
V
--S---QG
L
L
Y
S
VQGG
G
T
F
V
AS
R
S
A
K
S
A
L-HSNK
T
I
G
V
L
T
T
Y
I
S
D
Y
I
F
P
S
I
I
R
G
I
E
S
Y
L
S
EQG
Y
S
M
L
L
T
STNNNP
D
N
E
R
R
G
L
E
N
L
L
S
QHID
G
L
I
V------EP
T
K
S
ALQTPNI
G
Y
Y
L
N
LE-KNGI
P
F
A
M
INA
S
Y
A
EL-AAP
S
F
T
L
D
D
V-K
G
G
M
M
A
A
E
H
L
L
S
LGHT
H
M
M
G
I
F
KA--DD-T
Q
G
V
-
K
R
M
N
G
F
I
Q
A
H
R
ERELFPSP-
D
M
I
--
V
--
T
FT
T
-
E
E
K
E
S
--
K
L
L
E
K
V
K
A
T
L
EKNS--K---HM
P
T
A
I
L
C
YND
E
I
A
L
K
V
I
D
M
L
R
EMDLKVPED
M
S
I
V
GYDDS
H
F
A
Q
I
S
E
V
K
L
TSVK
H
P
K
S
V
L
G
K
A
A
A
K
Y
V
I
D
C
L
E
HKK-PKQEDVIF
E
P
E
L
I
I
R
Q
S
A
R
KLNE
1
PsiBlast_PDB
87.21
100%
-102
- C2 -
3TB6
2
ARAR_BACSU
A:
[15-297]
------------------------------------------------------------------------------------
N
K
T
I
G
V
L
T
T
Y
I
S
D
Y
I
F
P
S
I
I
R
G
I
E
S
Y
L
S
E
Q
G
Y
S
M
L
L
T
S
T
N
N
N
P
D
N
E
R
R
G
L
E
N
L
L
S
Q
H
I
D
G
L
I
V
------
E
P
T
K
S
A
L
Q
T
P
N
I
G
Y
Y
L
N
L
E
-
K
N
G
I
P
F
A
M
I
N
A
S
Y
A
E
L
-
A
A
P
S
F
T
L
D
D
V
-
K
G
G
M
M
A
A
E
H
L
L
S
L
G
H
T
H
M
M
G
I
F
K
A
--
D
D
-
T
Q
G
V
-
K
R
M
N
G
F
I
Q
A
H
R
E
R
E
L
F
P
S
P
-
D
M
I
--
V
--
T
F
T
T
-
E
E
K
E
S
--
K
L
L
E
K
V
K
A
T
L
E
K
N
S
--
K
---
H
M
P
T
A
I
L
C
Y
N
D
E
I
A
L
K
V
I
D
M
L
R
E
M
D
L
K
V
P
E
D
M
S
I
V
G
Y
D
D
S
H
F
A
Q
I
S
E
V
K
L
T
S
V
K
H
P
K
S
V
L
G
K
A
A
A
K
Y
V
I
D
C
L
E
H
K
K
-
P
K
Q
E
D
V
I
F
E
P
E
L
I
I
R
Q
S
A
R
K
L
N
-
21
PsiBlast_CBE
85.65
100%
-102
- C2 -
3TB6
2
ARAR_BACSU
B:
[16-298]
-------------------------------------------------------------------------------------
K
T
I
G
V
L
T
T
Y
I
S
D
Y
I
F
P
S
I
I
R
G
I
E
S
Y
L
S
E
Q
G
Y
S
M
L
L
T
S
T
N
N
N
P
D
N
E
R
R
G
L
E
N
L
L
S
Q
H
I
D
G
L
I
V
------
E
P
T
K
S
A
L
Q
T
P
N
I
G
Y
Y
L
N
L
E
-
K
N
G
I
P
F
A
M
I
N
A
S
Y
A
E
L
-
A
A
P
S
F
T
L
D
D
V
-
K
G
G
M
M
A
A
E
H
L
L
S
L
G
H
T
H
M
M
G
I
F
K
A
--
D
D
-
T
Q
G
V
-
K
R
M
N
G
F
I
Q
A
H
R
E
R
E
L
F
P
S
P
-
D
M
I
--
V
--
T
F
T
T
-
E
E
K
E
S
--
K
L
L
E
K
V
K
A
T
L
E
K
N
S
--
K
---
H
M
P
T
A
I
L
C
Y
N
D
E
I
A
L
K
V
I
D
M
L
R
E
M
D
L
K
V
P
E
D
M
S
I
V
G
Y
D
D
S
H
F
A
Q
I
S
E
V
K
L
T
S
V
K
H
P
K
S
V
L
G
K
A
A
A
K
Y
V
I
D
C
L
E
H
K
K
-
P
K
Q
E
D
V
I
F
E
P
E
L
I
I
R
Q
S
A
R
K
L
N
E
85
HHSearch
77.39
95%
-27
- C2 -
3TB6
2
ARAR_BACSU
A:
[15-297]
------------------------------------------------------------------------------------
N
K
T
I
G
V
L
T
T
Y
I
S
D
Y
I
F
P
S
I
I
R
G
I
E
S
Y
L
S
E
Q
G
Y
S
M
L
L
T
S
T
N
N
N
P
D
N
E
R
R
G
L
E
N
L
L
S
Q
H
I
D
G
L
I
V
------
E
P
T
K
S
A
L
Q
T
P
N
I
G
Y
Y
L
N
L
E
-
K
N
G
I
P
F
A
M
I
N
A
S
Y
A
E
L
-
A
A
P
S
F
T
L
D
D
V
-
K
G
G
M
M
A
A
E
H
L
L
S
L
G
H
T
H
M
M
G
I
F
K
A
--
D
D
-
T
Q
G
V
-
K
R
M
N
G
F
I
Q
A
H
R
E
R
E
L
F
P
S
P
-
D
M
I
--
V
T
F
T
T
E
E
-
K
E
--
S
--
K
L
L
E
K
V
K
----
A
T
L
E
-
K
N
S
K
H
M
P
T
A
I
L
C
Y
N
D
E
I
A
L
K
V
I
D
M
L
R
E
M
D
L
K
V
P
E
D
M
S
I
V
G
Y
D
D
S
H
F
A
Q
I
S
E
V
K
L
T
S
V
K
H
P
K
S
V
L
G
K
A
A
A
K
Y
V
I
D
C
L
E
H
K
K
P
K
Q
-
E
D
V
I
F
E
P
E
L
I
I
R
Q
S
A
R
K
L
N
-
15
PsiBlast_PDB
53.29
27%
-5
- C2 -
1VPW
2
PURR_ECOLI
A:
[50-329]
-------------------------------------------------------------------------
A
R
S
M
K
--
V
-
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CSEYP
E
P
L
L
A
M
L
E
----------
E
-
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
-
G
V
I
P
G
PL
E
R
-
N
T
G
A
-
G
R
L
A
G
F
M
K
A
M
E
E
-
A
M
I
K
V
P
-
E
S
W
--
I
--
V
Q
G
D
-
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
-----
Q
--
P
---
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
-
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
------
17
PsiBlast_PDB
53.13
27%
-5
- C2 -
2PUF
2
PURR_ECOLI
A:
[50-329]
-------------------------------------------------------------------------
A
R
S
L
K
--
V
-
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CSEYP
E
P
L
L
A
M
L
E
----------
E
-
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
-
G
V
I
P
G
PL
E
Q
-
N
T
G
A
-
G
R
L
A
G
F
M
K
A
M
E
E
-
A
M
I
K
V
P
-
E
S
W
--
I
--
V
Q
G
D
-
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
-----
Q
--
P
---
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
-
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
------
12
PsiBlast_PDB
53.07
26%
-4
- C2 -
1QQB
2
PURR_ECOLI
A:
[54-329]
-------------------------------------------------------------------------------
A
V
-
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CSEYP
E
P
L
L
A
M
L
E
----------
E
-
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
-
G
V
I
P
G
PL
E
R
-
N
T
G
A
-
G
R
L
A
G
F
M
K
A
M
E
E
-
A
M
I
K
V
P
-
E
S
W
--
I
--
V
Q
G
D
-
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
-----
Q
--
P
---
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
-
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
------
18
PsiBlast_PDB
52.94
27%
-2
- C2 -
2PUG
2
PURR_ECOLI
A:
[50-329]
-------------------------------------------------------------------------
A
R
S
L
K
--
V
-
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CSEYP
E
P
L
L
A
M
L
E
----------
E
-
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
-
G
V
I
P
G
PL
E
Q
-
N
T
G
A
-
G
R
L
A
G
F
M
K
A
M
E
E
-
A
M
I
K
V
P
-
E
S
W
--
I
--
V
Q
G
D
-
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
-----
Q
--
P
---
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
-
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
------
10
PsiBlast_PDB
52.63
26%
-2
- C2 -
1QP7
2
PURR_ECOLI
A:
[54-329]
-------------------------------------------------------------------------------
A
V
-
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
MCSEYP
E
P
L
L
A
M
L
E
----------
E
-
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
-
G
V
I
P
G
PL
E
R
-
N
T
G
A
-
G
R
L
A
G
F
M
K
A
M
E
E
-
A
M
I
K
V
P
-
E
S
W
--
I
--
V
Q
G
D
-
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
-----
Q
--
P
---
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
-
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
------
8
PsiBlast_PDB
52.56
27%
5
- C2 -
1JFT
3
PURR_ECOLI
A:
[50-329]
-------------------------------------------------------------------------
A
R
S
L
K
--
V
-
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
MCSEYP
E
P
L
L
A
M
L
E
----------
E
-
Y
R
H
I
P
M
V
V
M
D
A
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
-
G
V
I
P
G
PL
E
R
-
N
T
G
A
-
G
R
L
A
G
F
M
K
A
M
E
E
-
A
M
I
K
V
P
-
E
S
W
--
I
--
V
Q
G
D
-
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
-----
Q
--
P
---
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
-
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
------
11
PsiBlast_PDB
52.26
26%
-2
- C2 -
1QQA
2
PURR_ECOLI
A:
[54-329]
-------------------------------------------------------------------------------
A
V
-
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CSEYP
E
P
L
L
A
M
L
E
----------
E
-
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
-
G
V
I
P
G
PL
E
R
-
N
T
G
A
-
G
R
L
A
G
F
M
K
A
M
E
E
-
A
M
I
K
V
P
-
E
S
W
--
I
--
V
Q
G
D
-
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
-----
Q
--
P
---
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
-
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
------
9
PsiBlast_PDB
52.24
26%
-3
- C2 -
1BDH
2
PURR_ECOLI
A:
[54-329]
-------------------------------------------------------------------------------
A
V
-
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CSEYP
E
P
L
L
A
M
L
E
----------
E
-
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
-
G
V
I
P
G
PL
E
R
-
N
T
G
A
-
G
R
L
A
G
F
M
K
A
M
E
E
-
A
M
I
K
V
P
-
E
S
W
--
I
--
V
Q
G
D
-
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
-----
Q
--
P
---
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
-
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
------
66
HHSearch
52.04
19%
-65
- C2 -
2O20
3
?
A:
[62-332]
-----------------------------------------------------------------------------------
R
T
T
T
V
G
V
I
L
P
T
I
T
S
T
Y
F
A
A
I
T
R
G
V
D
D
I
A
S
M
Y
K
Y
N
M
I
L
A
N
S
D
N
D
V
E
K
E
E
K
V
L
E
T
F
L
S
K
Q
V
D
G
I
V
Y
------
M
G
S
S
L
D
E
-----
K
I
R
T
S
L
K
-
N
S
R
T
P
V
V
L
V
G
T
I
D
G
D
K
-
E
I
P
S
V
N
I
D
Y
H
-
L
A
A
Y
Q
S
T
K
K
L
I
D
S
G
N
K
K
I
A
Y
I
M
G
S
--
L
K
D
V
E
N
T
-
E
R
M
V
G
Y
Q
E
A
L
L
E
A
N
I
E
F
D
E
-
N
L
V
FE
G
--
N
Y
S
Y
E
Q
G
-------
K
A
L
A
E
----
R
L
L
--
E
---
R
G
A
T
S
A
V
V
S
H
D
T
V
A
V
G
L
L
S
A
M
M
D
K
G
V
K
V
P
E
D
F
E
I
I
S
G
A
N
S
P
I
T
Q
Y
T
Y
P
T
L
T
S
V
N
Q
P
L
Y
D
L
G
A
V
A
M
R
L
L
T
K
L
M
L
K
E
D
V
E
Q
-
N
Q
L
V
L
D
H
E
I
F
S
R
R
S
T
K
----
20
PsiBlast_PDB
51.87
27%
2
- C2 -
2PUB
2
PURR_ECOLI
A:
[50-329]
-------------------------------------------------------------------------
A
R
S
L
K
--
V
-
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CSEYP
E
P
L
L
A
M
L
E
----------
E
-
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
-
G
V
I
P
G
PL
E
A
-
N
T
G
A
-
G
R
L
A
G
F
M
K
A
M
E
E
-
A
M
I
K
V
P
-
E
S
W
--
I
--
V
Q
G
D
-
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
-----
Q
--
P
---
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
-
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
------
16
PsiBlast_PDB
51.83
27%
-0
- C2 -
2PUE
2
PURR_ECOLI
A:
[50-329]
-------------------------------------------------------------------------
A
R
S
L
K
--
V
-
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CSEYP
E
P
L
L
A
M
L
E
----------
E
-
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
-
G
V
I
P
G
PL
E
Q
-
N
T
G
A
-
G
R
L
A
G
F
M
K
A
M
E
E
-
A
M
I
K
V
P
-
E
S
W
--
I
--
V
Q
G
D
-
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
-----
Q
--
P
---
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
-
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
------
19
PsiBlast_PDB
51.73
27%
-3
- C2 -
2PUA
2
PURR_ECOLI
A:
[50-329]
-------------------------------------------------------------------------
A
R
S
L
K
--
V
-
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CSEYP
E
P
L
L
A
M
L
E
----------
E
-
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
-
G
V
I
P
G
PL
E
A
-
N
T
G
A
-
G
R
L
A
G
F
M
K
A
M
E
E
-
A
M
I
K
V
P
-
E
S
W
--
I
--
V
Q
G
D
-
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
-----
Q
--
P
---
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
-
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
------
7
PsiBlast_PDB
51.05
29%
-53
- C2 -
4RK1
5
?
A:
[8-263]
-------------------------------------------------------------------------------------
K
T
I
G
V
L
V
P
D
I
T
N
P
F
F
S
T
L
M
R
G
I
E
D
I
L
Y
K
Q
N
F
V
T
I
L
C
N
A
D
------
I
E
Y
L
A
E
L
T
R
R
G
V
D
G
F
I
I
--------
A
T
S
A
V
S
T
D
A
I
N
E
--
N
L
K
-
K
Q
G
R
P
F
I
V
L
D
Q
K
K
S
E
G
-
F
S
D
A
V
R
T
D
D
F
-
R
G
G
Y
L
A
G
M
H
L
L
S
L
G
H
Q
T
I
A
L
V
Y
P
E
--
N
P
-
P
E
N
V
H
A
R
I
E
G
F
K
S
A
L
D
V
Y
Q
I
-
P
H
D
-
Q
L
I
--
L
--
L
P
T
Q
-
F
S
K
Q
G
--
G
Y
--
Q
I
T
A
E
L
L
D
S
A
--
A
------
T
G
V
F
A
L
N
D
E
L
A
F
G
L
Y
R
G
L
E
E
A
G
K
S
I
P
E
D
Y
S
I
I
G
Y
D
N
I
D
M
C
E
Y
I
K
P
K
L
T
T
I
A
Q
P
I
F
E
L
G
Q
T
S
A
K
L
L
L
D
R
I
Q
F
P
E
-
K
E
W
E
E
------------------
74
HHSearch
50.88
20%
-55
- C2 -
3H5O
2
?
A:
[63-333]
-------------------------------------------------------------------------------------
R
T
V
L
V
L
I
P
S
L
A
N
T
V
F
L
E
T
L
T
G
I
E
T
V
L
D
A
A
G
Y
Q
M
L
I
G
N
S
H
Y
D
A
G
Q
E
L
Q
L
L
R
A
Y
L
Q
H
R
P
D
G
V
L
I
------
T
G
L
S
H
A
E
-----
P
F
E
R
I
L
S
-
Q
H
A
L
P
V
V
Y
M
M
D
L
A
-
D
D
-
G
R
C
C
V
G
F
S
Q
E
-
D
A
G
A
A
I
T
R
H
L
L
S
R
G
K
R
R
I
G
F
L
G
A
Q
--
L
D
-
E
R
V
M
-
K
R
L
D
G
Y
R
A
A
L
D
A
A
D
C
R
D
A
G
L
E
W
L
--
D
PQ
P
S
S
M
Q
M
G
-------
A
D
M
L
D
----
R
A
L
A
E
R
---
P
D
C
D
A
L
F
C
C
N
D
D
L
A
I
G
A
L
A
R
S
Q
Q
L
G
I
A
V
P
E
R
L
A
I
A
G
F
N
D
L
Q
P
A
A
W
C
T
P
P
L
T
T
V
A
T
P
R
R
D
I
G
V
H
A
A
K
A
L
L
Q
L
I
D
G
E
E
P
A
S
-
R
R
A
D
L
G
F
R
L
M
L
R
R
S
S
E
G
---
76
HHSearch
50.43
22%
-59
- C2 -
3CTP
2
?
A:
[60-325]
------------------------------------------------------------------------------------
S
K
T
I
G
L
M
V
P
N
I
S
N
P
F
F
N
Q
M
A
S
V
I
E
E
Y
A
K
N
K
G
Y
T
L
F
L
C
N
T
D
D
D
K
E
K
E
K
T
Y
L
E
V
L
Q
S
H
R
V
A
G
I
I
A
------
S
R
S
Q
C
E
---------
D
E
Y
A
-
N
I
D
I
P
V
V
A
F
E
N
H
I
L
-
D
-
N
I
I
T
I
S
S
D
N
Y
-
N
G
G
R
M
A
F
D
H
L
Y
E
K
G
C
R
K
I
L
H
I
K
G
P
--
E
V
F
E
A
T
E
-
L
R
Y
K
G
F
L
D
G
A
R
A
K
D
L
E
I
D
F
-
I
E
F
Q-
H
--
D
F
Q
V
-
K
M
-----
L
-
E
E
D
I
N
----
S
M
K
D-
I
---
V
N
Y
D
G
I
F
V
F
N
D
I
A
A
A
T
V
M
R
A
L
K
K
R
G
V
S
I
P
Q
E
V
Q
I
I
G
F
D
N
S
F
I
G
E
L
L
Y
P
S
L
T
T
I
N
Q
P
I
E
A
L
A
Y
T
I
I
E
L
L
I
K
I
I
N
G
E
G
V
L
I
-
E
D
Y
I
M
E
V
K
L
I
E
R
E
T
T
I
S
---
75
HHSearch
49.98
25%
33
- C2 -
1QPZ
2
PURR_ECOLI
A:
[1-334]
---------------------------
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
------
M
C
S
E
Y
P
E
-----
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
F
T
D
A
V
I
D
N
A
F
-
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
--
L
E
R
N
T
G
A
-
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
-
S
W
I
V
Q
G
--
D
F
E
P
E
S
G
-------
Y
R
A
M
Q
----
Q
I
L
SQ
P
---
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
-
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
P
-
87
HHSearch
49.31
27%
-37
- C2 -
4RK0
1
?
A:
[7-274]
------------------------------------------------------------------------------------
S
K
T
I
G
V
I
V
P
D
I
T
N
P
F
F
A
Q
L
I
R
G
I
E
S
V
L
Y
K
E
N
F
I
L
I
L
C
N
A
D
Q
D
V
T
R
E
H
E
Y
L
T
E
L
I
R
R
S
V
D
G
F
V
I
------
A
S
S
E
I
S
N
----
Q
T
I
N
E
T
L
R
-
A
K
K
I
P
F
I
V
L
D
Q
K
K
A
E
G
-
F
S
D
A
V
L
T
D
D
Y
-
R
G
G
Q
L
A
A
K
H
L
Q
E
Q
R
H
E
Q
V
I
V
V
M
P
P
--
H
A
P
V
N
I
Q
-
Q
R
L
K
G
F
C
S
V
Y
T
E
K
V
Q
L
I
E
-------
T
--
E
L
S
K
T
G
G
-------
Y
Q
A
V
P
----
E
I
L
--
K
---
T
E
S
T
G
I
F
A
I
N
D
E
I
A
F
G
L
Y
R
G
L
A
E
A
G
K
K
I
P
E
D
Y
S
I
I
G
Y
D
N
V
D
M
C
E
Y
V
S
P
P
L
T
T
I
A
Q
P
V
F
Q
L
G
Q
T
T
A
T
L
L
L
E
R
I
H
Q
P
A
K
D
W
-
E
E
Q
T
L
P
V
Q
L
I
E
R
F
S
T
A
P
L
K
-