@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu38410: (2016-08-03 )
MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAIENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAAAFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLPILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQGSMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQIMTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIWSMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAAIGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATLFLGFKEETE
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.......---..10...-------...--..20........30........40........50....--------....60..------....-.-.70.....------...80...--------.....90........100.......110.......--120.......130...--..-..--140....-----...150.----......--160----.......170.......180-----...---.....190.......200.......210.......220--..--.......230-.---.--......-----240.---------------------------------------....-------..250....-...260--.........270.......280.....-...------290..-.....-300.......310--------------.--..-.----...320..----....---.330....-...---------.340...------.----...350...----------------------....360.......370...--......380--.....----....390.-...-..-..400...-------....410.-.----.....420...----.----....430..--.....440.......450------.........--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
H
K
E
I
A
K
---
E
L
L
L
LAG-------GKN--
N
I
I
S
I
SHC
T
T
R
L
R
F
DVKDE
T
K
I
D
I
H
A
IENLQGV
Q
G
T
F
F
--------
R
Y
G
L
F
Q
I
I
------FG
A
G
-
V
-
V
N
K
I
Y
K
E
V
------
V
H
V
W
ETAP--------SEEP
V
H
Q
K
K
A
SRKL
N
P
A
A
A
F
A
K
T
L
S
D
I
F
V
P
I
I
P
A
I
--
T
A
S
G
L
L
M
G
L
I
G
M
I
K
V
F
--
H
W
-FA--AG
S
P
W
I
K
-----
M
L
D
L
V
SS----
T
A
F
I
L
L
--
P
I
L
----
V
G
F
S
A
A
R
QFGSNP
Y
L
G
A
V
I
------
A
G
L
---LTHPDLL
D
P
S
MLGSKTPSS
L
D
I
W
G
L
HIPMMGYQG
S
M
----
I
P
--
I
L
L
S
V
F
V
M
S
--
K
---
I
--
E
K
L
L
K
S
-----IVPK---------------------------------------SL
D
V
-------
V
I
I
P
F
I
T
V
M
-
V
T
G
C
----
L
A
L
I
VMN
P
A
A
S
I
I
G
Q
I
M
T
Q
S
I
-
V
Y
I
YD-HAG------
I
A
A
G
A
-
L
F
G
G
I
-
Y
S
T
I
V
L
S
G
L
H
H
S
F
--------------
Y
--
A
I
-
E
----
A
T
L
LANPH----V
G
V
N
---
F
L
V
-
P
I
W
S
-
M
A
N
---------
V
AQGGA
G
------
L
----
A
V
F
L
KTKQS----------------------S
L
K
K
IAL
P
A
S
L
T
A
F
L
--
G
I
V
--
E
P
I
V
FGV----
N
L
K
L
I
----
R
P
F
I
G
-
A
A
-
I
GG-AI-G
G
A
Y
V
V
A
V
-------
Q
V
V
A
NSYG-L----TG
I
P
M
I
S
-
I
V
L----P----FG
A
A
N
F
V
H
Y
--
M
I
G
F
L
I
A
A
V
S
A
F
I
A
T
L
--------
F
LGFKEETE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
68.20
17%
-141
- C5 -
3QNQ
8
?
A:
[3-434]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
E
K
---
Y
V
M
P
V
A
G
-------
K
V
A
--
E
-------------------
Q
R
H
L
L
A
I
R
D
G
L
V
L
T
M
P
F
L
--------
I
I
G
S
I
F
L
I
------
I
S
T
L
-
P
-
I
P
G
--------------
Y
S
E
F
M
--------
A
S
L
F
G
K
N
W
N
V
A
L
G
Y
P
V
S
A
T
F
N
I
M
A
L
I
A
V
F
G
I
A
Y
R
L
--
G
E
Y
Y
K
V
D
A
L
A
S
G
A
L
S
L
--
V
T
-
F
L
--
L
A
T
P
F
Q
V
-----
A
Y
I
M
P
G
T
----
K
E
S
I
L
V
--
D
-------
G
V
I
P
A
A
L
M
G
S
Q
G
L
F
V
A
M
I
------
I
A
I
---
I
S
T
E
I
Y
R
F
L
V
Q
K
K
M
I
I
K
M
P
E
---
T
V
P
P
A
V
T
R
S
F
A
A
L
----
I
P
--
G
F
I
V
V
T
V
V
W
--
I
---
I
--
R
L
I
F
E
H
-----
T
T
F
G
---------------------------------------
S
I
H
N
-------
V
V
G
K
L
-------------
L
Q
E
P
L
S
I
L
G
A
S
L
W
G
A
V
I
A
V
I
L
-
V
H
V
L
W
-
A
C
G
------
I
H
G
A
T
-
I
V
G
G
V
-
M
S
P
I
W
L
S
L
M
D
Q
N
R
--------------
I
--
A
F
-
Q
----
A
G
Q
-
D
V
P
N
----
T
I
T
A
---
Q
F
F
-
D
L
W
--------------
I
Y
M
G
G
S
G
A
T
L
A
L
V
V
----
G
M
L
L
F
A
R
S
Q
----------------------
Q
L
K
S
L
G
R
L
S
I
A
P
G
I
F
--
N
I
N
--
E
M
V
T
F
G
M
PIVM
N
P
L
L
L
----
I
P
F
I
V
-
V
P
-
V
V
L
-
T
I
-
V
S
Y
F
A
M
E
W
-------
G
L
V
A
R
P
S
G
-
A
AVTW
T
T
P
I
L
F
S
-
G
Y
L
G
S
G
G
K
----
I
S
G
V
I
L
Q
L
V
--
N
F
A
L
A
F
V
I
Y
L
P
F
L
K
I
W
--------
D
K
Q
K
I
A
E
E
K
GEA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
65.44
14%
-120
* C5 *
3QNQ
8
?
A:
[12-423]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
G
K
V
A
E
Q
R
H
L
L
A
I
R
D
G
L
V
L
T
M
P
F
L
--
I
I
G
S
I
F
L
I
I
S
T
L
P
I
P
G
Y
S
E
F
-
M
A
S
L
F
G
K
N
W
N
V
-----
A
L
G
Y
P
V
S
----
A
T
F
N
I
M
--
A
L
I
A
V
F
G
I
A
Y
R
L
G
E
Y
Y
K
V
D
A
L
A
S
G
A
L
------
S
L
V
T
F
L
L
A
T
P
F
Q
V
A
Y
-
I
M
P
G
T
K
E
S
I
L
V
D
G
V
I
P
A
A
-
L
M
G
S
Q
G
L
----
F
V
--
A
M
I
I
A
I
I
S
T
--
E
---
I
--
Y
R
F
L
V
Q
K
KM
I
I
K
M
P
E
---------------------------------------
T
V
P
P
A
V
T
R
S
F
A
A
L
I
P
G
F
I
V
V
T
V
V
W
I
----
I
R
L
I
F
E
H
T
T
F
G
S
I
H
N
V
V
G
K
L
L
Q
E
P
L
S
I
L
G
A
S
------
L
W
G
A
V
-
I
A
V
I
L
-
V
H
V
L
W
A
C
G
I
H
G
A
T
--------------
I
V
G
G
V
-
M
S
P
I
W
L
S
L
M
D
Q
N
R
I
A
F
Q
A
G
Q
D
VPN
T
I
T
A
Q
F
F
D
L
W
I
Y
---------
M
G
G
S
G
A
T
------
L
A
L
V
V
G
M
L
L
F
A
R
S
Q
----------------------
Q
L
K
S
L
G
R
L
S
I
A
P
G
I
F
--
N
I
N
--
E
M
V
T
F
G
M
----
P
I
V
M
N
P
L
L
L
I
P
F
I
V
-
V
P
-
V
V
L
-
T
I
-
V
S
Y
F
A
M
E
W
-------
G
L
----
V
A
R
P
----
S
G
A
A
V
T
W
T
T
P
I
----
L
F
S
G
Y
L
G
S
G
G
K
I
S
G
--
V
I
L
Q
L
V
N
F
A
L
A
F
V
I
Y
L
P
-------
F
L
K
I
W
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
64.09
17%
-37
- C2 -
4C1N
2
?
A:
[1-442]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLT
G
L
E
I
Y
K
H
L
P
K
---
K
N
C
K
E
C
G
--------
Q
P
--
T
C
L
A
F
A
M
Q
I
A
A
G
K
A
G
L
D
A
C
P
Y
V
S
D
E
A
K
E
L
L
E
S
A
S
A
P
------------
P
V
A
L
I
K
------
V
G
K
G
-
E
K
V
L
E
I
G
H
E
T
------
V
L
F
R
H
D
K
R
--------
F
E
H
P
C
G
L
A
I
L
V
E
D
T
L
S
E
G
E
I
K
E
R
V
E
K
I
N
K
L
V
F
D
R
V
GQ
M
H
S
V
N
L
V
A
L
K
G
S
S
Q
D
A
--
A
T
-
F
A
--
K
A
---
V
A
-----
T
A
R
E
V
T
D
----
L
P
F
I
L
I
G
T
P
E
Q
----
L
A
A
A
L
E
T
E
G
A
N
N
P
L
L
Y
A
A
-------------------------------
T
A
D
N
Y
E
Q
M
V
E
L
A
K
K
Y
N
------
V
P
--
L
T
V
S
A
K
G
L
D
--
A
---
L
--
A
E
L
V
Q
K
-----
I
T
A
L
---------------------------------------
G
Y
K
N
----------------------------
L
I
L
D
P
Q
P
----
E
N
I
S
E
G
L
-
F
Y
Q
T
Q
-
I
R
R
------
L
A
I
K
K
-
L
F
R
P
F
G
Y
P
T
I
A
F
A
L
D
E
N
P
Y
--------------
Q
--
A
V
M
E
----
A
S
V
Y
I
A
K
Y
----
A
G
I
I
---
V
L
N
-
T
V
-----
E
---------
P
A
D
I
L
P
L
------
I
----
T
L
R
L
N
I
Y
T
D
----------------------
P
Q
K
P
I
A
V
E
P
K
V
Y
E
I
L
--
N
P
G
PD
A
P
V
F
I
T
T
----
N
F
S
L
T
----
Y
F
C
V
A
-
G
D
-
V
E
G
-
A
R
-
I
P
A
Y
I
L
P
V
DTDGTS
V
L
T
A
W
A
A
G
K
-
F
----
T
P
E
K
I
A
Q
-
F
L
K
----
E
----
S
G
I
A
E
K
V
N
H
--
R
K
A
I
L
P
G
G
V
A
V
L
S
G
K
L
Q
E
L
SG
W
E
I
L
V
G
P
R
E
S
S
G
I
N
S
F
I
K
Q
RW-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
62.79
49%
-208
- C4 -
3IPJ
1
?
A:
[6-79]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
A
N
---
E
L
I
K
I
I
G
--------
E
D
--
N
I
I
S
I
T
H
C
A
T
R
L
R
V
M
V
K
D
R
E
I
I
N
D
K
K
V
E
K
V
D
E
V
K
G
V
F
F
--------
T
S
G
Q
Y
Q
I
I
------
L
G
T
G
-
I
-
V
N
K
V
Y
A
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_CBE
62.08
49%
-202
- C4 -
3IPJ
2
?
B:
[6-79]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
A
N
---
E
L
I
K
I
I
G
--------
E
D
--
N
I
I
S
I
T
H
C
A
T
R
L
R
V
M
V
K
D
R
E
I
I
N
D
K
K
V
E
K
V
D
E
V
K
G
V
F
F
--------
T
S
G
Q
Y
Q
I
I
------
L
G
T
G
-
I
-
V
N
K
V
Y
A
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
61.24
16%
-27
- C3 -
4U3E
6
?
A:
[12-670]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGLVGSH
M
K
V
Q
Y
S
F
E
R
E
F
E
E
L
M
S
D
L
L
S
K
Y
G
Y
E
M
F
Q
M
D
G
L
G
--
D
Q
L
D
V
V
K
F
T
E
D
F
V
R
R
G
I
I
E
S
T
I
D
A
N
A
N
V
R
V
T
N
I
S
T
Y
F
I
E
IS
K
P
H
T
Y
L
Y
S
L
Y
R
I
W
Q
K
M
K
E
M
F
G
K
G
-
V
-
A
D
E
F
V
E
A
Q
I
N
GA
V
Y
L
H
D
R
H
H
A
A
L
M
P
Y
CFAY
T
L
K
P
I
V
E
K
G
L
P
F
I
K
T
I
K
S
E
P
A
K
H
L
S
T
F
I
Q
H
V
I
Q
F
V
M
-
F
A
S
N
Q
S
S
G
A
V
G
L
P
D
F
F
--
V
W
M
W
Y
--
F
V
K
K
D
L
K
E
GIIP
R
D
K
L
D
W
Y
----
I
E
Q
H
F
Q
--
I
L
T
----
Y
S
L
N
Q
P
I
R
T
T
Q
S
P
Y
T
N
F
T
Y
LD
R
N
Y
I
K
A
I
---
F
E
G
E
R
Y
P
D
G
S
L
I
T
D
H
V
E
D
I
I
A
L
Q
K
H
Y
W
E
W
V
S
R
E
R
E
R
Q
M
F
T
F
P
--
V
L
T
A
S
L
L
Y
K
DG
K
---
F
LD
E
D
S
A
R
F
-----
I
N
K
I
N
MKWQD
T
N
W
Y
I
S
DSIDAVASCE
K
L
K
G
R
M
N
SIGGSDLNIG
S
F
K
V
-------
I
T
V
N
L
P
R
I
A
-
L
E
S
G
GD
R
E
K
Y
L
Q
I
L
R
H
R
V
Q
L
I
K
K
A
L
A
A
V
R
-
E
I
I
K
E
-
R
I
S
E
GLLPL
Y
E
N
G
L
M
L
L
N
R
Q
-
Y
G
T
I
G
V
T
G
V
W
E
S
A
S
I
M
GL
T
T
E
D
ID
G
L
K
Y
--
T
E
-
E
----
G
E
V
F
V
D
N
V
----
L
D
T
I
---
R
E
E
-
A
E
K
G
-
Y
H
E
YG
F
T
F
N
I
E
Q
V
P
A
E
K
A
A
------
V
----
T
L
A
Q
K
D
R
F
L
FGEKQPFEIYSNQWVPLMANTD
V
L
N
R
I
R
Y
S
G
K
W
D
K
K
V
SG
G
A
I
--
L
H
I
N
L
G
E
----
S
F
K
T
E
----
E
E
S
F
N
M
V
K
M
I
A
D
M
G
V
M
Y
F
A
F
N
T
K
I
-------
S
V
C
E
D
G
H
A
-
F
----
Y
G
E
R
-----
C
P
----
V
----
C
G
K
A
K
V
D
E
Y
M
R
I
V
G
Y
L
V
P
V
S
A
F
N
K
E
R
R
--------
E
I
E
Y
P
R
R
Q
F
YDSLTIR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
59.67
43%
-164
- C4 -
3IPJ
1
?
A:
[5-87]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
N
K
I
A
N
---
E
L
I
K
I
I
--------
G
E
D
--
N
I
I
S
I
T
H
C
A
T
R
L
R
V
M
V
K
D
R
E
I
I
N
D
K
K
V
E
K
V
D
E
V
K
G
V
F
F
--------
T
S
G
Q
Y
Q
I
I
------
L
G
T
G
I
V
-
N
K
-
V
Y
A
E
V
------
E
K
M
G
L
K
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
56.79
33%
-159
* C4 *
3BP3
1
PTGCB_ECOLI
A:
[2-81]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
S
E
M
A
P
---
A
L
V
A
A
F
G
-------
G
K
E
--
N
I
T
N
L
D
A
C
I
T
R
L
R
V
S
V
A
D
V
S
K
V
D
Q
A
G
L
K
K
L
-
G
A
A
G
V
V
V
--------
A
G
S
G
V
Q
A
I
------
F
G
T
K
-
S
-
D
N
-
L
K
T
E
M
------
D
E
Y
I
R
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
53.22
41%
-21
- C4 -
3IPJ
1
?
A:
[1-95]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNAN
K
Y
N
K
I
A
N
---
E
L
I
K
I
I
G
--------
E
D
--
N
I
I
S
I
T
H
C
A
T
R
L
R
V
M
V
K
D
R
E
I
I
N
D
K
K
V
E
K
V
D
E
V
K
G
V
F
F
--------
T
S
G
Q
Y
Q
I
I
------
L
G
T
G
-
I
-
V
N
K
V
Y
A
E
V
------
E
K
M
G
L
K
T
L
--------
S
K
K
E
Q
D
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
52.80
38%
-154
- C4 -
3BP3
1
PTGCB_ECOLI
A:
[5-65]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
A
P
---
A
L
V
A
A
F
G
-------
G
K
E
--
N
I
T
N
L
D
A
C
I
T
R
L
R
V
S
V
A
D
V
S
K
V
D
Q
A
G
L
K
K
L
-
G
A
A
G
V
V
V
--------
A
G
S
G
V
Q
A
I
------
F
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
52.52
38%
-171
- C4 -
1O2F
-
B:
[314-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
A
A
---
A
L
V
A
A
F
G
-------
G
K
E
--
N
I
T
N
L
D
A
C
I
T
R
L
R
V
S
V
A
D
V
S
K
V
D
Q
A
G
L
K
K
L
-
G
A
A
G
V
V
V
--------
A
G
S
G
V
Q
A
I
------
F
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_CBE
49.89
38%
-152
- C4 -
3BP3
1
B:
[7-65]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
---
A
L
V
A
A
F
G
-------
G
K
E
--
N
I
T
N
L
D
A
C
I
T
R
L
R
V
S
V
A
D
V
S
K
V
D
Q
A
G
L
K
K
L
-
G
A
A
G
V
V
V
--------
A
G
S
G
V
Q
A
I
------
F
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
48.82
20%
-34
- C1 -
5A22
2
L_VSIVA
A:
[35-2109]
NHADYNLNSPLIS
D
D
I
D
N
L
I
R
K
F
N
SLPIPSMWDSKNW
D
G
V
L
E
M
L
T
S
C
Q
A
N
P
I
S
T
S
Q
M
H
K
W
M
G
S
W
LMSDNHDA
S
Q
G
Y
S
F
L
H
E
V
D
K
E
A
E
I
T
F
D
V
V
E
T
F
I
R
G
W
GN
K
P
I
E
YIKKERW
T
D
S
F
K
I
L
A
Y
L
C
Q
K
F
L
D
L
H
K
L
T
L
I
L
N
AVS
E
V
E
L
L
N
L
A
R
T
F
K
G
K
V
R
R
S
SHG
T
N
I
C
R
I
R
V
PSL
G
P
T
F
I
S
EG
W
A
Y
F
K
KL
D
I
L
M
D
R
N
F
L
L
M
V
K
D
V
I
I
G
R
M
Q
T
V
L
S
M
VCRIDNLFS
E
Q
D
I
F
S
L
L
N
I
Y
R
I
G
D
K
I
V
E
R
QGNFS
Y
D
L
I
K
M
V
E
P
I
C
N
---
L
K
L
M
K
L
A
-------
R
E
S
RP
L
V
P
Q
F
P
H
F
E
N
H
I
K
T
S
V
D
E
G
A
K
I
D
----------
R
G
I
R
F
--------
L
H
D
Q
I
M
S
V
------
K
T
V
D
-
L
-
T
L
V
I
Y
G
S
F
------
R
H
W
G
H
P
-------------
F
I
D
Y
Y
T
G
L
E
K
L
H
S
Q
V
T
M
K
K
D
I
D
---------
V
--
S
Y
A
K
A
L
A
S
D
L
A
R
I
V
L
F
--
Q
Q
-
F
N
--
D
H
K
K
W
F
V
-----
N
G
D
L
L
P
H
DH
P
F
K
S
H
V
K
E
--
N
T
W
----
P
T
A
A
Q
V
Q
D
F
G
D
K
W
H
E
L
P
L
I
------
K
-
C
---
F
E
I
P
D
L
L
D
P
S
I
I
Y
S
D
K
S
H
S
M
N
R
S
E
V
L
K
H
V
R
M
N
P
N
T
P
----
I
P
S
K
K
V
L
Q
T
M
L
D
T
--
K
ATN
W
--
K
E
F
L
K
E
-----
I
D
E
K
---------------------------------------
G
L
D
---------------------------------
D
D
D
L
I
I
G
L
K
G
K
E
R
-------------------
E
L
K
-
L
A
G
R
F
-
F
S
L
--
M
S
W
K
L
R
E
Y
--------------
F
--
V
I
-
T
----
E
Y
L
I
K
T
H
-------------
F
V
-
P
M
F
K
-
G
L
T
---------
M
A
D
D
------------------------------------------------------------------------------
L
T
A
V
I
----
K
K
M
L
D
-
S
S
-
S
G
Q
--------------------------
G
-
L
----
K
S
Y
E
A
I
C
-
I
A
N
----
H
----
I
D
Y
E
K
W
N
N
H
--
Q
-
R
K
L
S
N
G
P
V
F
R
V
M
G
Q
--------
F
L
G
Y
P
S
L
I
E
R
T
H
E
F
F
E
K
S
L
I
Y
Y
NGRPDL
M
R
V
H
NNTLINSTSQRVCWQGQEGGLEGLR
Q
K
G
W
T
I
L
N
L
L
V
I
Q
R
E
AKIRN
T
A
V
K
V
L
A
QGD
N
Q
V
I
C
T
Q
Y
K
T
K
KSRNV
V
E
L
Q
G
A
L
N
Q
M
V
S
N
N
E
K
I
M
T
A
I
K
I
G
T
G
K
L
G
L
L
I
N
DD
E
T
M
Q
S
A
D
Y
L
N
Y
GK
I
P
I
F
RG
V
I
R
G
L
E
T
K
R
W
S
R
VTCVTNDQIPT
C
A
N
I
M
S
S
V
S
T
N
A
L
T
V
A
H
F
AENPI
N
A
M
I
Q
Y
N
Y
F
G
T
F
A
R
L
L
L
M
M
HDPALRQSLYEVQDKIPGLHS
S
T
F
K
Y
A
M
L
YLDPSIGGVSGMSLSRFLIRAFPD
P
V
T
E
S
L
S
F
W
R
F
I
H
V
H
ARSE
H
L
K
E
M
S
A
V
F
G
N
PEIAKFR
I
T
H
I
D
K
L
V
E
DPT
S
L
N
I
AMGMS
P
A
N
L
L
K
T
E
V
K
K
C
L
I
E
S
RQTIRN
Q
V
I
K
D
A
T
I
Y
L
Y
H
E
E
D
R
L
R
S
F
L
W
S
INPLF
P
R
F
L
S
E
F
K
S
G
TFL
G
V
A
D
G
L
I
S
LFQ
N
S
R
T
I
R
N
SFKKKYH
R
E
L
D
D
L
I
V
R
S
E
V
S
S
L
T
H
L
G
K
L
HLRRGSCKMWTCS
A
T
H
A
D
T
L
R
Y
K
S
W
GRTVIGTTVPH
P
L
E
M
L
G
P
Q
H
R
KETPCAPCNTSGFN
Y
V
S
V
H
C
P
DGIHDVFSSRGP
L
P
A
Y
L
G
S
KTSESTSILQPWERESKVP
L
I
K
R
A
T
R
L
R
D
A
ISWFVEPDSKL
A
M
T
I
L
S
N
I
H
S
L
T
GEEWTKRQHGFKRTGSALHRFSTSRMSHGGFASQST
A
A
L
T
R
L
MATTDTMRDLGDQNFDFL
F
Q
A
T
L
L
Y
A
Q
I
T
T
T
V
A
R
DGWIT
S
C
T
D
H
Y
H
IACKSCL
R
P
I
E
E
I
T
L
D
S
S
MDYTPPDVS
H
V
L
K
T
W
R
NGEGQS
Y
Q
V
G
R
C
I
G
F
L
Y
G
D
L
A
Y
R
KSTHAEDSSLFPLSIQGRIRG
R
G
F
L
K
G
L
L
D
G
L
M
R
A
S
C
C
Q
V
I
H
R
R
SLAHLKR
P
A
N
A
V
Y
G
G
L
I
Y
L
I
D
K
L
S
V
SP
P
F
L
S
L
T
R
S
G
P
I
R
D
E
L
E
T
I
P
H
K
I
P
TSYPTS
N
R
D
M
G
V
I
V
R
N
Y
F
K
Y
Q
C
R
L
I
E
K
G
K
Y
R
SHYSQLWLFSDVLSIDF
I
G
P
F
S
I
S
T
T
L
L
Q
I
LYKPFLSGK
D
K
N
E
L
R
E
L
A
N
L
S
S
L
L
R
SYPPWGR
E
S
R
G
T
I
T
T
I
P
V
Y
Y
T
TTPYPKM
L
E
M
P
P
R
I
QNP
L
L
S
G
I
RLGQLPTG
A
H
Y
K
I
R
S
I
L
H
GM
G
I
H
Y
R
D
F
L
S
C
GDGSG
G
M
T
A
A
L
L
R
E
N
VH
S
R
G
I
F
N
S
LLELSGSVMRGASPEPPSALETLGGDKSRCVNGETCWEYPSDLCDP
R
T
W
D
Y
F
L
R
L
K
A
G
LGLQID
L
I
V
M
DMEVRD
S
S
T
S
L
K
I
E
T
N
V
R
N
YVHRILDEQ
G
V
L
I
Y
K
T
Y
G
T
Y
I
C
ESEK
N
A
V
T
I
LGP
M
F
K
T
V
D
L
V
QTEFSSSQ
T
S
E
V
Y
M
VCKP
D
W
S
S
I
N
E
S
W
K
N
LYAFQS
S
E
Q
E
F
A
R
A
K
K
V
S
T
YFTLTGIPSQFIPDPF
V
N
I
E
T
M
L
Q
I
F
GVP
T
G
V
S
H
A
A
A
L
K
S
S
D
R
PAD
L
L
T
I
S
L
F
Y
M
A
I
I
S
Y
Y
N
INH
I
R
V
G
P
I
PPNPPSD
G
I
A
Q
N
V
G
I
A
I
T
G
I
S
F
W
L
S
L
M
E
KD
I
P
L
Y
Q
Q
C
L
A
V
I
Q
QSF
P
I
R
W
E
A
V
S
VKGG
Y
K
Q
K
W
S
T
RGDGLPK
D
T
R
I
S
DS
L
A
P
I
G
N
W
I
R
S
L
E
L
V
R
N
Q
V
R
L
N
P
FN
E
I
L
F
N
Q
L
C
R
T
V
D
NHLK
W
S
N
L
R
RNTGMIEWIN
R
R
I
S
K
EDRSILM
L
K
S
D
L
H
E
E
N
S
W
R
D
5
PsiBlast_PDB
48.45
37%
-171
- C4 -
3BP8
-
PTGCB_ECOLI
C:
[1-60]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
P
---
A
L
V
A
A
F
G
-------
G
K
E
--
N
I
T
N
L
D
A
C
I
T
R
L
R
V
S
V
A
D
V
S
K
V
D
Q
A
G
L
K
K
L
-
G
A
A
G
V
V
V
--------
A
G
S
G
V
Q
A
I
------
F
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
47.29
32%
-146
- C4 -
1IBA
-
A:
[15-92]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
P
---
A
L
V
A
A
F
G
-------
G
K
E
--
N
I
T
N
L
D
A
C
I
T
R
L
R
V
S
V
A
D
V
S
K
V
D
Q
A
G
L
K
K
L
-
G
A
A
G
V
V
V
--------
A
G
S
G
V
Q
A
I
------
F
G
T
K
-
S
-
D
N
-
L
K
T
E
M
------
D
E
Y
I
R
N
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
44.25
38%
-169
- C4 -
1IBA
-
A:
[15-74]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
P
---
A
L
V
A
A
F
G
-------
G
K
E
--
N
I
T
N
L
D
A
C
I
T
R
L
R
V
S
V
A
D
V
S
K
V
D
Q
A
G
L
K
K
L
-
G
A
A
G
V
V
V
--------
A
G
S
G
V
Q
A
I
------
F
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
36.47
57%
-195
- C6 -
3W37
1
?
A:
[425-471]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Y
L
G
S
V
W
------
P
G
P
---
V
Y
Y
P
D
F
L
D
P
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
35.05
57%
-181
- C6 -
3WEL
2
?
A:
[425-471]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Y
L
G
S
V
W
------
P
G
P
---
V
Y
Y
P
D
F
L
D
P
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
34.80
57%
-173
- C6 -
3WEO
1
?
A:
[425-471]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Y
L
G
S
V
W
------
P
G
P
---
V
Y
Y
P
D
F
L
D
P
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
34.45
57%
-192
- C6 -
3W38
1
?
A:
[425-471]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Y
L
G
S
V
W
------
P
G
P
---
V
Y
Y
P
D
F
L
D
P
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------