@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0026: (2016-04-18 )
MAFDAAMSTHEDLLATIRYVRDRTGDPNAWQTGLTPTEVTAVVTSTTRSEQLDAILRKIRQRHSNLYYPAPPDREQGDAARAIADAEAALAHQNSATAQLDLQVVSAILNAHLKTVEGGESLHELQQEIEAAVRIRSDLDTPAGARDFQRFLIGKLKDIREVVATASLDAASKSALMAAWTSLYDASKGDRGDADDRGPASVGSGGAPARGAGQQPELPTRAEPDCLLDSLLLEDPGLLADDLQVPGGTSAAIPSASSTPSLPNLGGATMPGGGATPALVPGVSAPGGLPLSGLLRGVGDEPELTDFDERGQEVRDPADYEHSNEPDERRADDREGADEDAGLGKSESPPQAPTTVTLPNGETVTAASPQLAAAIKAAASGTPIADAFQQQGIAIPLPGTAVANPVDPARISAGDVGVFTATPLPLALAKLFWTARFNTSQPCEGQTF
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20-........30-------...---......40......-.-.--50........--60......------..70.-..----.....80.....---------...90---.-------...----....100....---------------...110.....---------..120.......130.-......140.......150......---.160.......170..-.....180.......190-....-....200.---......210.......220.......230.......240.......250.....----..260.......270---.......-----280......--.290.......-300------.......310.......320---........330.......340.......350.......-360.......370.......380.......390..------------......400-------.---...---------.....410..--...----..420-----.--------.-....------...430........440......---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAF
D
A
A
M
S
T
H
E
D
L
L
A
T
I
R
Y
V
R
-DRTGDP
N
A
W--------QTG---LTP
T
E
V
T
A
V
V
TSTT-
R
-
S
--
E
Q
L
D
A
I
L
R
K
I
--
R
Q
R
HSNLY------YPAPP-DR----EQG
D
A
A
R
A
I
A
D
A
---------
E
A
A
L
A---H-------QNS----ATA
Q
L
D
L
Q
V
V
S
---------------
A
I
L
N
A
H
L
KTVE---------G
G
E
S
L
H
E
L
Q
Q
E
I
E
A
A
V
-
R
I
R
SDLDTPA
G
A
R
D
F
Q
R
F
L
I
G
K
L
K
D
---
I
R
E
V
V
A
T
ASLD
A
A
S
K
S
-
A
L
M
A
A
W
T
S
L
YDASKGDR--GDAD-DRGPASVG---SGGAPARGAGQQPELPTRA
E
P
D
C
L
L
D
S
L
L
LEDPGLLADDLQVPGGTSAAIPSAS----STPSLPNLGGATMPG---GGATPAL-----VPGVSAPGG--L
P
L
S
G
L
L
R
GVG-DEP------ELT
D
F
D
ER
G
Q
EVRDPADYE----HSNEPDERRADDREGADEDAGLGKSESPPQA
P
T
T
V
TLP-NG
E
T
V
TAAS
P
Q
L
A
A
A
I
K
AAASGT
P
I
A
D
A
F
Q
Q-QG
I
------------
A
IPLPGT---------A---VAN---------PV
D
P
A
RISAG--
D
V
G
----
V
F
T-------A--------T-
P
L
P
L
------
A
L
A
K
-
L
F
W
TARFNTSQPCEGQTF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
70.56
18%
8
- C1 -
2IQH
-
?
A:
[21-489]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
T
E
I
R
A
S
V
G
K
M
I
D
G
I
G
R
F
Y
I
-
Q
M
C
T
E
L
K
L
S
--------
D
Y
E
---
G
R
L
I
Q
N
S
L
T
I
E
R
M
V
-
L
-
S
A
F
D
T
G
G
P
I
Y
R
R
V
DG
K
W
R
R
E
L
I
L
------
Y
D
K
E
E
-
I
R
----
R
I
W
R
Q
A
N
N
G
D
D
A
---------
T
A
G
L
T
---
H
M
M
I
W
H
S
N
L
N
D
----
A
T
Y
Q
R
T
R
A
L
V
R
---------------
T
G
M
D
P
R
M
C
S
L
M
---------
Q
G
S
T
L
P
R
R
S
G
A
A
G
A
A
V
-
K
-----
G
V
G
T
M
V
M
E
L
I
R
M
I
K
R
G
I
N
R
---
R
T
R
I
A
Y
E
R
M
C
N
I
L
K
G
K
-
F
Q
T
A
A
Q
R
T
M
V
D
Q
V
R
E
S
R
NP
G
N
A
E
-
F
E
D
L
I
F
L
A
---
R
S
A
L
I
L
R
G
S
V
A
H
K
----
S
C
L
P
A
C
V
Y
G
S
A
V
A
S
G
Y
D
F
E
R
E
G
Y
S
L
V
G
I
D
P
F
R
L
L
Q
N
S
----
Q
V
Y
S
L
I
R
P
N
E
N
P
A
H
K
---
S
Q
L
V
W
M
A
-----
C
H
S
-
A
A
F
E
D
--
L
R
V
S
S
F
I
R
G
T
K
-
V
V
P
------
R
-
G
K
L
S
T
R
G
V
Q
I
A
S
N
E
N
M
E
T
M
E
S
S
T
L
E
L
R
S
R
Y
W
A
I
R
T
R
S
G
G
N
T
S
S
G
Q
I
S
I
Q
P
T
F
S
V
Q
R
N
L
P
F
D
R
P
T
I
M
A
A
S
D
M
R
T
E
I
I
R
L
M
E
S
A
R
P
E
D
V
S
F
Q
G
-
R
G
V
-------------
F
E
L
S
D
E
---------
K
---
A
T
S
---------
P
I
V
P
--------------------------------------------------------
S
F
D
M
S
N
--
E
G
S
Y
F
F--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
66.35
26%
1
* C5 *
4C3X
9
?
A:
[23-530]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWTSECD
V
L
V
V
G
SG
G
G
A
L
T
G
A
Y
T
A
A
A
Q
G
L
T
T
I
V
L
E
K
T
D
R
F
G
G
T
S
A
Y
--------
S
G
A
SIW
L
P
G
T
Q
V
Q
E
R
A
G
L
P
D
-
S
-
T
--
E
N
A
R
T
Y
L
R
A
L
--
L
G
---------------
D
A
-
E
S
----
E
R
Q
D
A
Y
V
E
T
A
P
A
---------
V
V
A
L
L
---
E
-------
Q
N
P
-------
N
I
E
F
E
F
R
A
F
P
D
YYKAEGRMDTGR
S
I
N
P
L
D
L
D
P
A
D
---------
I
G
D
L
A
G
K
V
R
P
E
L
D
Q
D
----
R
T
G
Q
D
H
A
P
G
P
M
I
G
G
R
A
L
I
G
R
L
L
A
---
A
V
Q
S
T
G
K
A
E
L
R
T
E
S
-------
V
L
T
S
L
I
V
E
D
G
R
V
V
--
G
--------
A
E
V
E
---
S
G
G
E
T
Q
R
I
K
A
N
R
---------
G
V
L
M
A
A
G
G
I
E
G
N
A
E
M
R
E
Q
A
G
T
P
G
K
A
I
W
-----
S
----
M
G
P
F
G
A
N
T
G
D
A
I
S
A
G
I
A
V
G
G
A
T
A
L
L
DQAW
F
C
P
G
V
E
Q
P
D
G
SA
A
F
M
V
G
V
R
G
G
L
V
V
D
S
A
GERYLN
E
S
L
P
Y
D
Q
F
G
R
A
M
D
A
H
-
D
D
N
----
G
S
A
V
P
S
F
M
I
F
D
S
R
E
G
G
G
L
P
A
I
C
I
P
N
T
A
P
A
K
H
L
E
A
G
T
W
V
-
G
A
D
T
L
E
E
L
A
A
K
T
G
L
P
A
D
A
L
R
S
T
V
E
K
F
N
D
A
A
K
-
L
G
V
DEEFHRGEDPYD
A
F
F
C
P
P
N
---------
G
---
G
A
N
AALTAIENG
P
F
Y
A
A
R
I
V
L
S
--
D
L
G
TKG
G
L
V
T
-------
D
--------
V
-
N
G
R
V
L
R
ADGS
A
I
D
G
-
L
Y
A
A
G
--
N
T
S
A
S
L
S
G
R
F
Y
PGPG
V
P
L
G
T
A
M
V
F
S
Y
R
A
A
Q
D
M
A
K----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
59.10
18%
-3
- C3 -
3NOY
2
ISPG_AQUAE
A:
[10-358]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
Q
K
R
K
T
R
Q
I
R
V
G
N
-
V
K
I
G
---------------
G
---
D
A
P
I
V
V
Q
S
M
T
S
T
K
T
-
H
D
V
--
E
A
T
L
N
Q
I
K
R
L
--
Y
E
A
G
C
E
I
V
------
R
V
A
V
P
-
H
K
----
E
D
V
E
A
L
E
E
I
V
K
K
------------------------------------
S
P
M
P
V
I
A
---------------
D
I
H
F
A
P
S
Y
A
F
L
---------
S
M
E
K
G
V
H
-------
G
I
-
R
I
N
-----
P
G
N
I
--------
G
K
E
E
I
---
V
R
E
I
V
E
E
A
K
R
R
G
V
-
A
V
-
R
I
G
V
N
S
G
S
L
E
K
D
L
L
E
K
Y
--
G
Y
P
-------------
S
A
E
A
L
A
E
S
A
L
R
W
S
E
K
F
E
K
W
G
F
T
N
Y
K
V
S
I
K
G
S
D
----------
V
L
Q
N
V
R
A
N
L
I
F
A
----
E
R
T
D
V
P
L
H
I
G
I
T
E
A
G
---
M
G
T
K
G
I
I
-----
K
S
S
V
G
I
G
I
L
--
L
Y
-----
M
G
I
G
-
D
T
V
------
R
V
S
L
T
D
D
P
V
V
E
V
E
T
A
Y
E
I
L
----
K
S
L
G
L
R
R
R
G
----------------------
V
E
I
V
A
C
P
-
T
C
G
R
I
E
V
D
L
P
K
V
V
K
E
V
Q
E
K
L
S
G
V
K
T
P
L
K
V
A
V
-
M
G
C
------------
V
V
N
A
I
G
E
---------
A
----------------------
R
E
A
--
D
I
G
----
L
A
C
-------
G
--------
R
-
G
F
A
W
------
L
F
K
H
-
G
K
P
I
K
K
V
D
E
S
E
M
V
D
E
L
L
K
E
I
Q
N-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
57.53
18%
-23
* C3 *
4WD9
-
NISB_LACLL
A:
[5-1020]
S
F
K
A
Q
P
F
L
V
R
N
T
ILCPND
K
R
S
F
T
E
Y
T
Q
V
I
E
T
V
S
K
N
K
V
F
L
E
Q
L
L
L
A
N
P
K
L
Y
D
V
M
Q
K
Y
N
A
GLLKKKR
V
K
K
L
F
E
S
I
Y
K
Y
Y
K
R
S
Y
L
RSTPFGLF
S
E
T
S
I
G
V
F
S
K
S
S
Q
YKLM
G
K
T
T
K
GIRLD
T
Q
W
L
I
R
L
V
H
K
M
E
V
D
FSKK
L
S
F
T
R
NNA
N
Y
K
F
GD
R
V
F
Q
VYTINSSEL
E
E
V
N
I
K
YT
N
V
Y
Q
I
I
S
E
F
C
EN
D
Y
Q
K
Y
E
D
I
C
E
T
V
T
L
C
Y
GDEY
R
E
L
S
E
Q
Y
L
G
S
L
I
V
N
H
Y
-
L
I
S
N
L
Q
----------
K
D
L
--------
L
S
D
---
F
S
W
N
T
F
L
T
K
V
E
A
I
D
-
E
-
D
--
K
K
Y
I
I
P
L
K
K
V
--
Q
K
F
I
Q
E
Y
S
------------
E
I
----
E
I
G
E
G
I
E
K
L
K
E
I
---------
Y
Q
E
M
S
---
Q
I
L-----
E
N
D
----
N
Y
I
Q
I
D
L
I
S
D
S
---------------
E
I
-
N
F
D
V
K
Q
K
Q
---------
Q
L
E
H
L
A
E
F
L
G
N
T
T
K
S
V
-
R
-------
R
T
Y
L
D
D
Y
K
D
K
F
I
E
K
Y
G
V
---
D
Q
E
V
Q
I
T
E
L
F
D
--
S
T
F
-
G
I
G
A
P
Y
N
--
Y
N
H
P
---
R
--
N
D
F
Y
-
E
S
E
P
S
T
L
Y
---
Y
S
E
E
E
R
E
K
Y
L
S
M
Y
V
E
A
V
K
N
H
N
V
I
N
L
D
D
L
E
S
H
Y
Q
K
M
D
L
E
K
K
S
E
L
Q
G
L
E
L
F
L
N
L
A
K
E
YE
K
D
I
F
I
L
G
D
I
V
G
N
N
N
L
G
---
G
A
S
G
--------------------------
R
F
S
A
-
L
S
P
------
E
L
T
S
Y
H
R
T
I
V
D
S
V
E
R
E
N
E
N
----
K
--------------------------
E
I
T
S
C
E
I
V
F
L
P
-
E
N
------------
I
R
H
A
N
V
M
H
T
S
I
M
------
R
R
K
------------
V
L
P
F
F
T
S
---------
T
---
S
H
N
---------
E
V
L
L
T
N
I
Y
I
G
I
D
E
K
E
----
K
F
Y
-------
A
--------
R
D
I
S
T
Q
------
E
V
L
K
-
F
Y
I
T
S
M
Y
N
K
T
L
------
F
S
N
E
L
R
F
L
Y
E
I
S
L
DDKFGNL
P
W
E
L
I
Y
RDFDYI
P
R
L
V
F
DEIVIS
P
A
K
W
K
I
W
GRDVNSKMT
I
R
E
L
I
Q
S
K
EIPK
E
F
Y
I
V
NGD
N
K
V
Y
L
S
QKN
P
L
D
M
E
I
L
E
S
A
I
K
K
S
S
K
R
K
D
F
I
E
L
Q
E
Y
F
EDENIINKGE
K
G
R
V
A
D
V
V
V
P
F
IRAFIREKRVSVERREKLPFNE
W
L
Y
L
K
L
Y
I
S
INR
Q
N
E
F
L
L
SY
L
P
D
I
Q
K
I
V
A
N
L
G
G
N
L
F
F
L
R
Y
T
D
P
K
P
H
I
R
L
R
I
K
C
SD
L
F
L
A
Y
G
S
I
L
E
I
L
K
R
S
R
K
N
RIMS
T
F
D
I
S
I
Y
DQEVERYGG
F
D
T
L
E
L
S
E
A
I
F
C
A
D
S
K
I
I
P
N
L
L
T
L
I
K
DTNNDWK
V
D
D
V
S
I
L
V
N
Y
L
Y
L
K
C
F
F
QND
N
K
K
I
L
N
F
L
N
L
VGDQIFYD
K
N
F
K
E
L
K
H
A
I
K
N
L
F
L
K
M
I
A
Q
DFE
L
Q
K
V
Y
S
I
I
D
S
I
I
H
V
H
N
N
R
L
IGIERD
K
E
K
L
I
Y
Y
T
L
Q
R
L
F
V
S
EETKDFNLD
L
V
S
V
SK
31
Fugue
53.25
17%
-14
- C2 -
1P68
-
?
A:
[1-102]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Y
G
K
-
L
-
N
--
D
L
L
E
D
L
Q
E
V
L
--
K
N
L
H
K
N
W
H
------
G
G
K
D
N
L
H
D
----
V
D
N
H
L
Q
N
V
I
E
D
I
---------
H
D
F
M
Q
---
G
-------
G
G
S
GGKL
Q
E
M
M
K
E
F
Q
Q
V
L
---------------
D
E
L
N
N
H
L
Q
--
G
---------
G
K
H
T
V
H
H
I
E
Q
N
I
K
E
I
F
-
H
H
L
E
E
L
V
H
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
50.36
24%
14
- C2 -
2XLQ
4
CLOQ_STRRC
A:
[3-148]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
------
M
P
A
L
P
-
I
D
----
Q
E
F
D
C
E
R
F
R
A
D
I
---------
R
A
T
A
A
---
A
-------
I
G
A
----
P
I
A
H
---
R
L
T
D
---------------
T
V
L
E
A
F
R
D
N
F
A
---------
Q
G
A
T
L
W
K
T
T
S
Q
--------------
P
G
D
Q
L
S
Y
R
F
F
S
R
L
K
M
D
T
---
V
S
R
A
I
D
A
G
L
L
D
A
A
H
P
T
L
A
V
V
D
A
W
S
S
L
Y
G
G
A
P
V
Q
S
--
G
D
F
D
A
G
R
G
M
A
K
T
W
L
Y
F
G
G
L
R
P
A
E
D
I
L
T
V
P
A
L
P
A
S
V
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
48.00
24%
-83
- C4 -
3PBI
-
RIPB_MYCTU
A:
[156-217]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
Y
A
F
A
G
-
V
G
V
------------
L
I
P
R
F
S
G
D
Q
Y
------
N
---
A
G
R
---------
H
V
P
P
A
E
A
K
R
G
--
D
L
I
----
F
Y
G
-------
P
GGG-----
Q
-
H
V
T
L
------
Y
L
G
N
G
Q
M
L
E
A
S
G
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
47.48
25%
0
- C4 -
4LC3
8
?
A:
[92-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
S
W
VST
S
N
V
I
I
E
T
G
---
A
T
P
--
V
F
A
D
I
D
P
V
T
-
R
-
N
--
I
D
L
D
K
L
E
Q
A
I
--
T
P
R
T
K
A
I
I
P
V
FLSG
L
P
V
D
M
-
D
R
L
Y
A
I
A
R
A
H
K
L
R
V
I
E
D
A
---------
A
Q
A
F
G
STW
H
-------
G
K
R
----
I
G
A
I
G
D
L
V
S
F
S
---------------
F
H
A
N
K
N
L
T
T
I
E
---------
G
G
A
L
V
L
N
N
E
D
E
A
V
L
A
Q
-
K
Y
R
L
Q
G
I
T
R
T
G
F
D
G
M
D
C
D
V
L
G
G
K
Y
N
---
L
T
D
V
A
A
R
V
G
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
47.13
17%
-89
- C4 -
4Q4G
-
X:
[1125-1184]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
Y
S
F
A
G
-
V
G
I
------------
K
L
P
H
Y
S
G
SQY------
N
---
L
G
R
---------
K
I
P
S
S
Q
M
R
R
G
--
D
V
I
----
F
Y
G
-------
P
NGS-----
Q
-
H
V
T
I
------
Y
L
G
N
G
Q
M
L
E
A
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
46.51
24%
16
- C2 -
2XLY
-
CLOQ_STRRC
A:
[7-145]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
Q
E
F
D
C
E
R
F
R
A
D
I
---------
R
A
T
A
A
---
A
-------
I
G
A
----
P
I
A
H
---
R
L
T
D
---------------
T
V
L
E
A
F
R
D
N
F
A
---------
Q
G
A
T
L
W
K
T
T
S
Q
--------------
P
G
D
Q
L
S
Y
R
F
F
S
R
L
K
M
D
T
---
V
S
R
A
I
D
A
G
L
L
D
A
A
H
P
T
L
A
V
V
D
A
W
S
S
L
Y
G
G
A
P
V
Q
S
--
G
D
F
D
A
G
R
G
M
A
K
T
W
L
Y
F
G
G
L
R
P
A
E
D
I
L
T
V
P
A
L
P
A
S
V
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
45.39
19%
-82
- C4 -
2K1G
-
MEPS_ECOLI
A:
[72-133]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
R
T
F
R
E
Q
F
G
L
------------
E
L
P
R
S
T
Y
---------
E
Q
Q
E
M
G
K
---------
S
V
S
R
S
N
L
R
T
G
--
D
L
V
----
L
F
R
-------
A
GSTG
R
---
H
-
V
G
-
I
------
Y
I
G
N
N
Q
F
V
H
A
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
45.28
20%
-74
- C4 -
2HBW
3
?
A:
[131-192]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
A
A
F
V
S
-
V
G
I
------------
W
L
P
R
D
A
Y
---------
Q
Q
E
A
F
T
Q
---------
A
I
T
I
D
E
L
A
P
G
--
D
L
V
----
F
F
G
-------
T
PVKA----
T
-
H
V
G
L
------
Y
L
G
D
G
C
Y
I
H
S
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
43.99
23%
-75
- C4 -
4LJ1
-
?
A:
[87-154]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
Y
A
Y
A
G
-
A
G
L
------------
K
L
P
R
S
S
G
---------
Q
M
Y
K
V
G
Q
---------
K
V
L
P
Q
Q
A
R
K
G
--
D
L
I
----
F
Y
G
-------
P
EGT-----
Q
-
S
V
A
L
------
Y
L
G
K
G
Q
M
L
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
42.23
12%
-16
- C2 -
2OPE
-
?
A:
[28-147]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
-
K
G
----
Y
Q
S
Q
L
Y
T
E
M
V
G
I
---------
N
N
I
S
K
---
Q
-------
F
I
L
----
K
N
P
L
D
D
N
Q
T
I
K
---------------
S
K
L
E
R
F
V
S
G
----------------
Y
K
M
N
P
K
I
A
E
K
Y
-
N
V
S
V
H
F
V
N
K
E
K
P
R
A
Y
S
--
L
V
G
V
P
K
T
GTG
Y
T
L
S
V
W
M
N
S
V
G
D
G
Y
K
C
-
R
D
A
A
S
A
R
A
H
L
E
T
L
S
S
D
V
--
G
C
E
A
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
41.98
11%
-12
- C2 -
4LWS
5
?
A:
[35-123]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
A
---
V
D
R
A
A
M
A
Q
A
A
Q
D
I
E
Q
S
-
A
--
N
A
I
R
G
M
Q
N
Q
L
--
A
S
A
K
D
Q
L
R
------
S
------
H
----
W
E
G
D
A
S
M
A
F
E
A
V
---------
F
N
R
F
N
---
E
-------
D
F
S
----
R
V
L
K
A
L
D
G
M
H
E
---------------
S
L
V
Q
T
R
I
T
Y
E
A
---------
R
E
E
A
A
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
37.03
22%
3
- C4 -
4FDY
-
?
A:
[250-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
W
V
Y
D
K
-
A
G
I
------------
S
L
P
R
V
A
Q
D
Q
Y
------
D
---
A
T
Q
---------
E
I
S
M
E
E
A
Q
A
G
--
D
L
I
----
F
F
H
-------
S
TYNAGTYV
T
-
H
V
A
I
------
Y
L
E
G
N
R
F
Y
H
A
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
36.97
11%
6
- C5 -
3TL4
-
SYQ_YEAST
X:
[2-187]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
-
V
E
E
L
T
Q
L
F
S
--------
Q
V
G
---
F
E
D
K
K
V
K
E
I
V
K
N
K
K
-
V
-
S
--
D
S
L
Y
K
L
I
K
E
T
--
P
S
-------------
D
Y
Q
W
-
N
K
----
S
T
R
A
L
V
H
N
L
A
S
F
VKGTDLPKS
E
L
I
V
N
---
G
-------
I
I
N
----
G
D
L
K
T
S
L
Q
V
D
A
---------------
A
F
K
Y
V
K
A
N
G
E
A
STKMGMNEN
S
G
V
G
I
E
I
T
E
D
Q
V
R
N
Y
V
M
Q
Y
I
Q
E
N
K
E
R
I
L
T
E
R
-
Y
K
L
V
P
G
I
F
A
D
---
V
K
N
---
L
K
E
L
K
W
A
D
P
R
-
S
F
K
P
I
I
D
Q
E
V
L
K
L
L
G
P
K
--
D
E
R
D
-
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
35.46
17%
-16
- C4 -
4HZ9
-
?
A:
[26-88]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
R
K
A
I
E
W
-
G
G
I
------------
S
L
Q
R
T
R
S
AKDY
G
P
S
L
L
A
---
A
G
F
---------
H
E
A
I
G
S
P
M
K
G
--
D
V
I
----
V
I
Q
P
APGHPH
G
--------
H
-
M
A
-
I
------
Y
D
G
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
35.25
24%
82
- C- -
2XM5
9
CLOQ_STRRC
A:
[8-148]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
I
D
----
Q
E
F
D
C
E
R
F
R
A
D
I
---------
R
A
T
A
A
---
A
-------
I
G
A
----
P
I
A
H
---
R
L
T
D
---------------
T
V
L
E
A
F
R
D
N
F
A
---------
Q
G
A
T
L
W
K
T
T
S
Q
--------------
P
G
D
Q
L
S
Y
R
F
F
S
R
L
K
M
D
T
---
V
S
R
A
I
D
A
G
L
L
D
A
A
H
P
T
L
A
V
V
D
A
W
S
S
L
Y
G
G
A
P
V
Q
S
--
G
D
F
D
A
G
R
G
M
A
K
T
W
L
YF
G
G
L
R
P
A
E
D
I
L
T
V
P
A
L
P
A
S
V
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
34.85
24%
83
- C- -
2XM7
9
CLOQ_STRRC
A:
[11-148]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
F
D
C
E
R
F
R
A
D
I
---------
R
A
T
A
A
---
A
-------
I
G
A
----
P
I
A
H
---
R
L
T
D
---------------
T
V
L
E
A
F
R
D
N
F
A
---------
Q
G
A
T
L
W
K
T
T
S
Q
--------------
P
G
D
Q
L
S
Y
S
F
F
S
R
L
K
M
D
T
---
V
S
R
A
I
D
A
G
L
L
D
A
A
H
P
T
L
A
V
V
D
A
W
S
S
L
Y
G
G
A
P
V
Q
S
--
G
D
F
D
A
G
R
G
M
A
K
T
W
L
Y
F
G
G
L
R
P
A
E
D
I
L
T
V
P
A
L
P
A
S
V
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------