@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0119: (2016-04-19 )
MASDFGPRIADLVEVAATRLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRVALRMGSNAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLIDADGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATSTPEGLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPRDATVAVMPLYHGHGLIASLLATLASGGAVSLPARGRFSAHTFWDDIKAVGATWYTAVPTIHQILLERSATEPSGRKPAALRFIRSCSAPLTAQAALALQTEFAAPVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRSTGAQIRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTITAANFTDGWLRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPHQLYGEAVAAVIVPRESAPPTREELVQFCRERLAAFEIPASFQEASGLPHTAKGSLDRRAVAERFGHSV
Atome Classification :
(22 SA)
.........10........20........30--.....-------....40........50.-.......60........70........80........90....-..--..100.......--110-..------.....--------120-...---.--..--...130....-.-..---.140-.......150...-....160.......-----170.-.--.....180.--......190.......200----.......210.......220.-..-....230.......-240.......250.......260.......270..--.....280....--....290.......300.......310........320.......330.......340.......350-.-.-.....360-......---.370.....-----..-380.......390....-.-..400.......410.......420........430.......440.......450.......460.......470..-----....-.480....-..-.490.......500.......510.......520...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MASDFG
P
R
I
A
D
L
V
E
V
A
A
T
RLPEA
P
A
L
V
V
T
A
---
D
R
I
A
I
-------
S
H
R
D
L
A
R
L
V
D
E
L
A
G
Q
L
T
-RSGLLPG
D
R
V
A
L
RMGSN
A
E
F
V
V
A
L
L
AASRA
D
L
V
V
V
PLDPALP
I
-
T
E
--
Q
R
V
R
S
QAAG
A
R
V
--
V
L
I
-DA------DGPHD--------R---AEP---T--T
R
--
W
W
P
L
T
-
V
N
VG-G-DS---GPSG-
G
T
L
S
V
H
L
DAATEP-NPATSTPEGLRPDD-----
A
M
I
M
-F--TGGTTGLPK--MVPWTH
A
N
I
A
S
S
V
R
A
I
I
TG----YRLSPRD
A
T
V
A
V
M
PLYHG
H
G
L
-
I
A
-
S
L
L
A
T
L
ASG
G
A
VSL-PARGRF
S
A
H
T
F
W
D
D
I
K
A
VG
A
T
W
Y
T
A
V
P
T
I
H
Q
I
L
L
E
--RSATEPS-GR
K
P
--
A
A
L
R
F
I
R
SCSAP
L
T
A
Q
A
A
L
A
L
QTEF-AA
P
V
V
C
AFGMTEAT
H
Q
V
T
T
T
Q
IEGIDQTETPVVSTGLVGRST-G-
A
-
Q
I
R
I
VGSD-GLPLPA---GA
V
G
E
I
W
L
R
-----
G
T
-
T
V
V
R
GYLGDP
T
I
T
AANF-T-DGWLRTGDLGSLSAAGDL
S
I
R
G
R
-
I
K
E
L
I
NRGGEKI
S
P
E
R
V
E
G
V
L
ASHP
N
V
M
E
A
A
V
FGV
P
H
Q
L
Y
G
E
A
V
A
A
V
I
V
PRESA-----PP
T
R
-
E
E
L
V
Q
F
C
R
-
E
R
-
L
A
A
FEIPA
S
F
Q
EASGLPHTAKGS
L
D
R
R
A
V
A
E
R
FGHSV
3
PsiBlast_PDB
88.77
29%
-87
- C2 -
1MDB
4
DHBE_BACSU
A:
[40-527]
---------------------------------
D
R
I
A
I
T
C
GN
T
H
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
-
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
-
S
E
--
I
T
Y
F
C
E
F
A
E
A
A
A
--
Y
I
I
P
D
A
------
Y
S
G
F
D
--------
Y
R
S
L
A
R
Q
---
V
--
Q
S
--
K
L
P
T
L
-
K
N
I
I
-
V
--
A
---
G
E
A
E
-
E
F
L
P
L
E
-
D
L
H
T
E
P
----
V
K
L
P
E
V
K
S
S
D
V
-----
A
F
L
Q
-
L
--
S
G
G
S
T
G
L
S
K
--
L
I
P
R
T
H
D
D
Y
I
Y
S
L
K
R
S
V
E
V
----
C
W
L
D
H
S
T
V
Y
L
A
A
L
P
M
A
H
N
Y
P
L
-
S
S
P
G
V
L
G
V
L
Y
A
G
G
R
V
V
L
S
P
S
P
S
P
D
D
A
F
P
L
---
I
E
R
E
K
V
T
I
T
A
L
V
P
P
L
A
M
V
W
M
D
--
A
A
S
S
R
R
D
-
D
L
----
S
S
L
Q
V
L
Q
V
G
G
A
K
F
S
A
E
A
A
R
R
V
K
A
V
F
-
G
C
T
L
Q
Q
V
F
G
M
A
E
G
L
V
N
Y
T
R
-----
L
D
D
P
E
E
I
I
V
N
T
Q
G
K
P
M
S
P
-
Y
-
D
-
E
S
R
V
W
D
D
H
-
D
R
D
V
K
P
---
G
E
T
G
H
L
L
T
R
-----
G
P
-
Y
T
I
R
G
Y
Y
K
A
E
E
H
N
A
A
S
F
-
T
E
D
G
F
Y
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
-
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
E
R
S
C
V
F
I
I
P
R
D
E
A
-----
P
K
A
--
A
E
L
K
A
F
L
R
-
E
R
G
L
A
A
Y
K
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
------
4
PsiBlast_PDB
88.67
29%
-86
- C2 -
1MDF
2
DHBE_BACSU
A:
[40-527]
---------------------------------
D
R
I
A
I
TCGN
T
H
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
-
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
-
S
E
--
I
T
Y
F
C
E
F
A
E
A
A
A
--
Y
I
I
P
D
A
------
Y
S
G
F
D
--------
Y
R
S
L
A
R
Q
---
V
--
Q
S
--
K
L
P
T
L
-
K
N
I
I
-
V
--
A
---
G
E
A
E
-
E
F
L
P
L
E
-
D
L
H
T
E
P
----
V
K
L
P
E
V
K
S
S
D
V
-----
A
F
L
Q
-
L
--
S
G
G
S
T
G
L
S
K
--
L
I
P
R
T
H
D
D
Y
I
Y
S
L
K
R
S
V
E
V
----
C
W
L
D
H
S
T
V
Y
L
A
A
L
P
M
A
H
N
Y
P
L
-
S
S
P
G
V
L
G
V
L
Y
A
G
G
R
V
V
L
S
P
S
P
S
P
D
D
A
F
P
L
---
I
E
R
E
K
V
T
I
T
A
L
V
P
P
L
A
M
V
W
M
D
--
A
A
S
S
R
R
D
-
D
L
----
S
S
L
Q
V
L
Q
V
G
G
A
K
F
S
A
E
A
A
R
R
V
K
A
V
F
-
G
C
T
L
Q
Q
V
F
G
M
A
E
G
L
V
N
Y
T
R
-----
L
D
D
P
E
E
I
I
V
N
T
Q
G
K
P
M
S
P
-
Y
-
D
-
E
S
R
V
W
D
D
H
-
D
R
D
V
K
P
---
G
E
T
G
H
L
L
T
R
-----
G
P
-
Y
T
I
R
G
Y
Y
K
A
E
E
H
N
A
A
S
F
-
T
E
D
G
F
Y
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
-
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
E
R
S
C
V
F
I
I
P
R
D
E
A
-----
P
K
A
--
A
E
L
K
A
F
L
R
-
E
R
G
L
A
A
Y
K
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
------
9
PsiBlast_PDB
88.20
29%
-87
- C2 -
1MD9
2
DHBE_BACSU
A:
[40-527]
---------------------------------
D
R
I
A
I
TCGN
T
H
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
-
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
-
S
E
--
I
T
Y
F
C
E
F
A
E
A
A
A
--
Y
I
I
P
D
A
------
Y
S
G
F
D
--------
Y
R
S
L
A
R
Q
---
V
--
Q
S
--
K
L
P
T
L
-
K
N
I
I
-
V
--
A
---
G
E
A
E
-
E
F
L
P
L
E
-
D
L
H
T
E
P
----
V
K
L
P
E
V
K
S
S
D
V
-----
A
F
L
Q
-
L
--
S
G
G
S
T
G
L
S
K
--
L
I
P
R
T
H
D
D
Y
I
Y
S
L
K
R
S
V
E
V
----
C
W
L
D
H
S
T
V
Y
L
A
A
L
P
M
A
H
N
Y
P
L
-
S
S
P
G
V
L
G
V
L
Y
A
G
G
R
V
V
L
S
P
S
P
S
P
D
D
A
F
P
L
---
I
E
R
E
K
V
T
I
T
A
L
V
P
P
L
A
M
V
W
M
D
--
A
A
S
S
R
R
D
-
D
L
----
S
S
L
Q
V
L
Q
V
G
G
A
K
F
S
A
E
A
A
R
R
V
K
A
V
F
-
G
C
T
L
Q
Q
V
F
G
M
A
E
G
L
V
N
Y
T
R
-----
L
D
D
P
E
E
I
I
V
N
T
Q
G
K
P
M
S
P
-
Y
-
D
-
E
S
R
V
W
D
D
H
-
D
R
D
V
K
P
---
G
E
T
G
H
L
L
T
R
-----
G
P
-
Y
T
I
R
G
Y
Y
K
A
E
E
H
N
A
A
S
F
-
T
E
D
G
F
Y
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
-
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
E
R
S
C
V
F
I
I
P
R
D
E
A
-----
P
K
A
--
A
E
L
K
A
F
L
R
-
E
R
G
L
A
A
Y
K
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
------
6
PsiBlast_PDB
87.88
27%
-92
- C2 -
4IZ6
2
ENTE_ECOLI
A:
[52-552]
-----------------
T
R
H
A
A
S
D
S
I
A
V
I
D
---
G
E
R
Q
L
-------
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
-
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
-----
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
--
Q
R
S
E
L
N
A
Y
A
S
Q
I
EP
A
L
L
-
I
A
------
D
R
Q
H
A
LFSGD
D
F
L
N
---
T
F
V
---
T
--
E
H
--
S
S
I
R
V
-
V
Q
L
L
-
N
-
D
S
---
G
E
H
---
N
L
Q
D
A
I
N
H
P
A
E
D
-
F
T
A
T
P
S
P
A
D
---
E
V
-----
A
Y
F
Q
-
L
--
S
G
G
-
T
G
T
P
K
--
L
I
P
R
T
H
N
D
Y
Y
Y
S
V
R
R
S
V
E
I
----
C
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
Y
A
M
-
S
S
P
G
S
L
G
V
F
L
A
G
G
T
V
V
L
-
A
A
D
P
--
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
Q
--
A
L
I
E
G
E
S
-
R
A
Q
L
--
A
S
L
K
L
L
Q
V
G
G
A
R
L
S
A
T
L
A
A
R
I
P
A
E
I
-
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
L
V
N
Y
T
R
-----
L
D
D
S
A
E
K
I
I
H
T
Q
G
Y
P
M
C
P
-
D
-
D
-
E
V
W
V
A
D
A
E
-
G
N
P
L
P
Q
---
G
E
V
G
R
L
M
T
R
-----
G
P
-
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
-
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
-
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
E
K
S
C
A
Y
L
V
V
K
E
-------
P
L
R
A
-
V
Q
V
R
R
F
L
R
-
E
Q
G
I
A
E
F
K
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
------
30
HHSearch
87.64
22%
-92
- C2 -
3C5E
7
ACS2A_HUMAN
A:
[54-561]
-----------------
G
K
R
P
P
S
P
A
L
W
W
V
N
GKG
K
E
L
M
W
-------
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
-
T
D
--
I
L
Y
R
L
Q
M
S
K
A
K
A
--
I
V
A
-
G
D
------
E
V
I
Q
E
--------
V
---
D
T
V
---
A
SE
C
P
--
S
L
R
I
K
-
L
L
V
S
-
E
-
K
S
-----
C
D
-
G
W
L
N
F
K
K
-
L
L
N
E
A
-
S
T
T
H
H
C
V
E
T
G
S
Q
E
A
-----
S
A
I
Y
-
F
--
T
S
G
T
S
G
L
P
K
--
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
D
A
G
W
----
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
-
L
C
-
S
L
M
E
P
W
A
L
G
A
C
T
F
V
-
H
L
L
P
K
F
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
Q
--
Q
D
L
S
----
S
Y
K
F
--
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
-
G
L
D
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
--------
M
K
I
K
P
G
Y
M
G
T
A
A
-
S
-
C
Y
D
V
Q
I
I
D
D
K
-
G
N
V
L
P
P
---
G
T
E
G
D
I
G
I
R
VKP
I
R
P
I
-
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
-
R
-
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
-
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
LSHD
P
E
Q
L
T
-
K
E
L
Q
Q
H
V
K
-
S
V
-
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
---
5
PsiBlast_PDB
86.68
27%
-85
- C2 -
3RG2
2
ENTB_ECOLI (first)
A:
[34-530]
-----------------
T
R
H
A
A
S
D
S
I
A
V
I
D
---
G
E
R
Q
L
-------
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
-
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
-----
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
--
Q
R
S
E
L
N
A
Y
A
S
Q
I
EP
A
L
L
-
I
A
------
D
R
Q
H
A
LFSGD
D
F
L
N
---
T
F
V
---
T
--
E
H
--
S
S
I
R
V
-
V
Q
L
L
-
N
-
D
S
---
G
E
H
N
-
L
Q
-----
D
A
I
N
H
P
A
E
D
F
T
A
T
P
S
---
P
A
D
-----
E
V
A
Y
-
F
Q
L
S
G
G
T
T
G
T
P
K
--
L
I
P
R
T
H
N
D
Y
Y
Y
S
V
R
R
S
V
E
I
----
C
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
Y
A
M
-
S
S
P
G
S
L
G
V
F
L
A
G
G
T
V
V
L
-
A
A
D
P
--
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
Q
--
A
L
I
E
G
E
S
-
R
A
Q
L
--
A
S
L
K
L
L
Q
V
G
G
A
R
L
S
A
T
L
A
A
R
I
P
A
E
I
-
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
L
V
N
Y
T
R
-----
L
D
D
S
A
E
K
I
I
H
T
Q
G
Y
P
M
C
P
-
D
-
D
-
E
V
W
V
A
D
A
E
-
G
N
P
L
P
Q
---
G
E
V
G
R
L
M
T
R
-----
G
P
-
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
-
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
-
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
E
K
S
C
A
Y
L
V
V
K
E
-------
P
L
R
A
-
V
Q
V
R
R
F
L
R
-
E
Q
G
I
A
E
F
K
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
------
2
PsiBlast_PDB
86.58
30%
-96
- C2 -
4FUQ
7
?
A:
[29-498]
-------------------------------------
I
-------
S
Y
A
E
L
V
A
R
A
G
R
V
A
N
V
L
V
-
A
R
G
L
Q
V
G
D
R
V
A
A
Q
T
E
K
S
V
E
A
L
V
L
Y
L
A
T
V
R
A
G
G
V
Y
L
P
L
N
T
A
Y
T
L
-
H
E
--
L
D
Y
F
I
T
D
A
E
P
K
I
--
V
V
C
-
D
--------------------------
P
---
S
--
K
R
DG
I
A
A
I
A
-
A
K
V
G
-
A
-
T
V
E
T
L
G
P
D
G
R
G
S
L
T
---
D
A
A
A
G
A
-
S
E
A
F
A
T
I
D
R
G
A
D
D
L
-----
A
A
I
L
-
Y
--
T
S
--
T
G
R
S
K
--
G
A
M
L
S
H
D
N
L
A
S
N
S
L
T
L
V
D
Y
----
W
R
F
T
P
D
D
V
L
I
H
A
L
P
I
Y
H
T
H
G
L
F
V
A
-
S
N
V
T
L
F
A
R
G
S
M
I
F
L
-
P
---
K
F
D
P
D
K
I
L
D
--
L
M
A
R
A
T
V
L
M
G
V
P
T
F
Y
T
R
L
L
Q
SP
R
L
T
K
E
T
T
-
G
H
M
------
R
L
F
I
S
G
S
A
P
L
L
A
D
T
H
R
E
W
S
A
K
T
-
G
H
A
V
L
E
R
Y
G
M
T
E
-
T
N
M
N
T
S
N
P
Y
D
G
---
D
R
V
P
----
G
A
V
G
P
A
L
P
G
-
V
-
S
A
R
V
T
D
P
E
T
G
K
E
L
P
R
---
G
D
I
G
M
I
E
V
K
-----
G
P
-
N
V
F
K
G
Y
W
R
M
P
E
K
T
K
S
E
F
R
D
-
D
G
F
F
I
T
G
D
L
G
K
I
D
E
R
G
Y
V
H
I
L
G
R
-
G
K
D
L
V
I
T
G
G
F
N
V
Y
P
K
E
I
E
S
E
I
D
A
M
P
G
V
V
E
S
A
V
I
G
V
P
H
A
D
F
G
E
G
V
T
A
V
V
V
R
D
K
G
A
-----
T
I
D
E
-
A
Q
V
L
H
G
L
D
-
G
Q
-
L
A
K
F
K
M
P
K
K
V
I
F
V
D
D
L
P
R
N
T
M
G
K
V
Q
K
N
V
L
R
E
T
Y
----
13
PsiBlast_PDB
85.83
25%
-89
- C2 -
3NI2
4
?
A:
[39-532]
-----------------------
P
C
L
I
N
G
A
---
N
G
D
V
Y
-------
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
-
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
-
A
E
--
L
A
K
H
A
K
A
S
R
A
K
L
--
L
I
T
-
Q
A
-------
C
Y
Y
E
--------
K
---
V
K
D
---
F
--
A
R
--
E
S
D
V
K
-
V
-
M
C
-
V
-
D
S
---
A
P
D
G
----
C
L
H
F
S
E
L
T
Q
A
-
D
E
N
E
A
P
Q
V
D
I
S
P
D
D
-----
V
V
A
L
P
Y
--
S
S
G
T
T
G
L
P
K
--
G
V
M
L
T
H
K
G
L
I
T
S
V
A
Q
Q
V
D
G
DNPN
L
Y
F
H
S
E
D
V
I
L
C
V
L
P
M
F
H
I
Y
A
L
-
N
S
-
I
M
L
C
G
L
R
V
G
A
P
I
L
I
---
M
P
K
F
E
I
G
S
L
L
G
L
I
E
K
Y
K
V
S
I
A
P
V
V
P
P
V
M
M
S
I
------
A
K
S
P
D
-
L
D
K
H
DL
S
S
L
R
M
I
K
S
G
G
A
P
L
G
K
E
L
E
D
T
V
R
A
K
F
P
Q
A
R
L
G
Q
G
Y
G
M
T
E
A
G
P
V
L
A
M
C
L
A
F
A
K
E
P
F
D
I
K
P
G
A
C
G
T
V
V
R
N
----
A
-
E
M
K
I
V
D
P
E
T
G
A
S
L
P
R
---
N
Q
P
G
E
I
C
I
R
-----
G
D
-
Q
I
M
K
G
Y
L
N
D
P
E
A
T
S
R
T
I
D
K
-
E
G
W
L
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
-
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
P
E
I
S
D
A
A
V
V
G
L
K
D
E
D
A
G
E
V
P
V
A
F
V
V
K
S
E
K
S
-----
Q
A
T
E
-
D
E
I
K
Q
Y
I
S
-
K
Q
-
V
I
F
Y
K
R
I
K
R
V
F
F
I
E
A
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
-----
42
HHSearch
85.39
26%
-85
- C2 -
1MDB
4
DHBE_BACSU
A:
[25-532]
------
E
T
F
G
D
L
L
R
D
R
A
A
K
Y
G
D
R
I
A
I
T
C
-----
G
N
T
H
W
-------
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
-
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
-
S
E
--
I
T
Y
F
C
E
F
A
E
A
A
A
--
Y
I
I
-
P
D
------
A
Y
S
G
F
--------
D
---
Y
R
S
---
L
--
A
R
--
Q
V
Q
S
K
L
P
T
L
K
-
N
I
I
V
---
A
G
E
A
-
E
E
F
L
-
P
L
E
D
-
L
H
T
-
E
-
P
V
K
L
P
E
V
K
S
S
D
V
-----
A
F
L
Q
-
L
--
S
G
G
S
T
G
L
S
K
--
L
I
P
R
T
H
D
D
Y
I
Y
S
L
K
R
S
V
E
V
----
C
W
L
D
H
S
T
V
Y
L
A
A
L
P
M
A
H
N
Y
P
L
-
S
S
P
G
V
L
G
V
L
Y
A
G
G
R
V
V
L
-
S
P
--
S
P
S
P
D
D
A
F
P
L
I
E
R
E
K
V
T
I
T
A
L
V
P
P
L
A
M
V
W
M
D
--
A
A
S
S
R
---
R
D
D
L
--
S
S
L
Q
V
L
Q
V
G
G
A
K
F
S
A
E
A
A
R
R
V
K
A
V
F
-
G
C
T
L
Q
Q
V
F
G
M
A
E
G
L
V
N
Y
T
R
L
D
D
-------
P
E
E
I
I
V
N
T
Q
G
K
P
M
-
S
P
Y
D
E
S
R
V
W
D
D
H
-
D
R
D
V
K
P
---
G
E
T
G
H
L
L
T
R
-----
G
P
-
Y
T
I
R
G
Y
Y
K
A
E
E
H
N
A
A
S
F
T
E
-
D
G
F
Y
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
-
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
E
R
S
C
V
F
I
I
P
R
D
E
A
------
P
K
A
-
A
E
L
K
A
F
L
R
-
E
R
G
L
A
A
Y
K
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
A
I
S
E
K
-
1
PsiBlast_PDB
84.58
26%
-93
- C2 -
3R44
2
FAC13_MYCTU
A:
[26-515]
----------------
A
T
V
S
P
R
L
Q
A
Y
V
E
P
S
---
T
D
V
R
M
-------
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
T
-
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
-
P
E
--
V
S
F
I
L
S
D
S
G
S
K
V
--
V
I
Y
-
G
A
PS
A
P
V
I
D
A
I
R
A
--------
Q
---
A
D
P
PGT
V
--
T
D
--
W
-------
I
G
-
A
-
D
S
----------
L
A
E
R
L
R
S
A
A
A
D
-
E
P
A
V
---
E
C
G
G
D
D
N
-----
L
F
I
M
-
Y
--
T
S
---
G
H
P
K
--
G
V
V
H
T
H
E
S
V
H
S
A
A
S
S
W
A
S
T
----
I
D
V
R
Y
R
D
R
L
L
L
P
L
P
M
F
H
V
A
A
L
-
T
T
-
V
I
F
S
A
M
R
G
V
T
L
I
S
M
-
P
---
Q
F
D
A
T
K
V
W
S
L
I
V
E
E
R
V
C
I
G
G
A
V
P
A
I
L
N
F
M
----
R
Q
V
P
E
F
A
-
E
L
D
A
--
P
D
F
R
Y
F
I
T
G
G
A
P
M
-
P
E
A
L
I
K
I
Y
A
A
K
-
N
I
E
V
V
Q
G
Y
A
L
T
E
S
C
G
G
G
T
L
L
L
------
S
E
D
A
L
R
K
A
G
S
A
G
R
A
T
M
F
-
T
-
D
V
A
V
R
G
D
D
-
G
V
I
R
E
H
---
G
E
-
G
E
V
V
I
K
-----
S
D
-
I
L
L
K
E
Y
W
N
R
P
E
A
T
R
D
A
F
-
D
-
N
G
W
F
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
R
-
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
I
G
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
K
W
G
E
I
A
A
A
I
V
V
A
D
Q
N
E
------
V
S
E
-
Q
Q
I
V
E
Y
C
G
-
T
R
-
L
A
R
Y
K
L
P
K
K
V
I
F
A
E
A
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
Q
Y
S
A
T
V
12
PsiBlast_PDB
84.48
25%
-88
- C2 -
3A9V
1
?
A:
[39-532]
-----------------------
P
C
L
I
N
G
A
---
N
G
D
V
Y
-------
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
-
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
-
A
E
--
L
A
K
H
A
K
A
S
R
A
K
L
--
L
I
T
-
Q
A
-------
C
Y
Y
E
--------
K
---
V
K
D
---
F
--
A
R
--
E
S
D
V
K
-
V
-
M
C
-
V
-
D
S
---
A
P
D
G
----
C
L
H
F
S
E
L
T
Q
A
-
D
E
N
E
A
P
Q
V
D
I
S
P
D
D
-----
V
V
A
L
P
Y
--
S
S
G
T
T
G
L
P
K
--
G
V
M
L
T
H
K
G
L
I
T
S
V
A
Q
Q
V
D
G
DNPN
L
Y
F
H
S
E
D
V
I
L
C
V
L
P
M
F
H
I
Y
A
L
-
N
S
-
I
M
L
C
G
L
R
V
G
A
P
I
L
I
---
M
P
K
F
E
I
G
S
L
L
G
L
I
E
K
Y
K
V
S
I
A
P
V
V
P
P
V
M
M
S
I
------
A
K
S
P
D
-
L
D
K
H
DL
S
S
L
R
M
I
K
S
G
G
A
P
L
G
K
E
L
E
D
T
V
R
A
K
F
P
Q
A
R
L
G
Q
G
Y
G
M
T
E
A
G
P
V
L
A
M
C
L
A
F
A
K
E
P
F
D
I
K
P
G
A
C
G
T
V
V
R
N
----
A
-
E
M
K
I
V
D
P
E
T
G
A
S
L
P
R
---
N
Q
P
G
E
I
C
I
R
-----
G
D
-
Q
I
M
K
G
Y
L
N
D
P
E
A
T
S
R
T
I
D
K
-
E
G
W
L
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
-
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
P
E
I
S
D
A
A
V
V
G
L
K
D
E
D
A
G
E
V
P
V
A
F
V
V
K
S
E
K
S
-----
Q
A
T
E
-
D
E
I
K
Q
Y
I
S
-
K
Q
-
V
I
F
Y
K
R
I
K
R
V
F
F
I
E
A
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
-----
19
PsiBlast_PDB
81.81
27%
-84
- C2 -
3CW9
5
?
A:
[4-501]
--------
V
N
E
M
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
P
A
---
R
G
L
R
L
-------
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
-
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
-
A
E
L
A
E
L
I
K
R
G
E
M
T
A
A
V
--
I
A
V
-
G
R
------
Q
---------------------------------
V
-
A
D
A
I
-
F
-
Q
S
---
G
-
S
G
-
A
R
I
I
F
L
G
D
L
V
R
D
G
-
E
P
Y
S
Y
G
P
P
I
E
D
P
Q
R
EPAQP
A
F
I
F
-
Y
--
T
S
G
T
T
G
L
P
K
A
A
I
I
P
Q
R
A
A
E
S
R
V
L
F
M
S
T
Q
V
G
----
L
R
H
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
A
-
V
L
V
A
A
L
A
L
D
G
T
Y
V
V
-
V
E
E
--
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
--
A
A
A
H
A
G
S
-
S
L
K
L
--
D
S
L
R
H
V
T
F
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
H
L
-
P
G
E
K
V
N
I
Y
G
T
T
E
A
M
N
S
L
Y
M
R
Q
P
K
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
V
R
I
G
-
G
-
G
-
V
D
E
I
V
A
N
-----------
G
E
E
G
E
L
I
V
A
-----
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
-
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
-
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
L
G
E
-----
T
L
S
A
-
D
A
L
D
T
F
C
R
S
S
E
-
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
-----
20
PsiBlast_PDB
81.63
27%
-81
- C2 -
3CW8
5
?
X:
[4-501]
--------
V
N
E
M
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
P
A
---
R
G
L
R
L
-------
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
-
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
-
A
E
LA
E
L
I
K
R
G
E
M
T
A
A
V
--
I
A
V
-
G
R
------
Q
---------------------------------
V
-
A
D
A
I
-
F
-
Q
S
---
G
-
S
G
-
A
R
I
I
F
L
G
D
L
V
R
D
G
-
E
P
Y
S
Y
G
P
P
I
E
D
P
Q
R
EPAQP
A
F
I
F
-
Y
--
T
S
G
T
T
G
L
P
K
AA
I
I
P
Q
R
A
A
E
S
R
V
L
F
M
S
T
Q
V
G
----
L
R
H
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
A
-
V
L
V
A
A
L
A
L
D
G
T
Y
V
V
-
I
E
E
--
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
--
A
A
A
H
A
G
S
-
S
L
K
L
--
D
S
L
R
H
V
T
F
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
H
L
-
P
G
E
K
V
N
I
Y
G
T
T
E
A
M
N
S
L
Y
M
R
Q
P
K
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
V
R
I
G
-
G
-
G
-
V
D
E
I
V
A
N
-----------
G
E
E
G
E
L
I
V
A
-----
A
S
D
S
A
F
V
G
Y
L
N
Q
P
E
A
T
A
E
K
L
-
Q
-
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
-
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
-
W
G
Q
S
V
T
A
C
V
V
P
R
L
G
E
-----
T
L
S
A
-
D
A
L
D
T
F
C
R
S
S
E
-
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
-----
15
PsiBlast_PDB
81.19
27%
-83
- C2 -
2QW0
1
?
X:
[4-501]
--------
V
N
E
M
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
P
A
---
R
G
L
R
L
-------
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
-
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
-
A
E
LA
E
L
I
K
R
G
E
M
T
A
A
V
--
I
A
V
---------
Q
---------------------------------
V
-
A
D
A
I
-
F
-
Q
S
---
G
-
S
G
-
A
R
I
I
F
L
G
D
L
V
R
D
G
-
E
P
Y
S
Y
G
P
P
I
E
D
P
Q
R
EPAQP
A
F
I
F
-
Y
--
T
S
---
G
L
P
K
AA
I
I
P
Q
R
A
A
E
S
R
V
L
F
M
S
T
Q
V
G
----
L
R
H
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
A
-
V
L
V
A
A
L
A
L
D
G
T
Y
V
V
-
V
E
E
--
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
--
A
A
A
H
A
G
S
-
S
L
K
L
--
D
S
L
R
H
V
T
F
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
H
L
-
P
G
E
K
V
N
A
Y
G
T
T
E
A
M
N
S
L
Y
M
R
Q
P
K
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
V
R
I
G
-
G
-
G
-
V
D
E
I
V
A
N
-----------
G
E
E
G
E
L
I
V
A
-----
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
-
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
-
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
L
G
E
-----
T
L
S
A
-
D
A
L
D
T
F
C
R
S
S
E
-
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
-----
17
PsiBlast_PDB
81.14
27%
-82
- C2 -
2QVY
1
?
X:
[4-501]
--------
V
N
E
M
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
P
A
---
R
G
L
R
L
-------
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
-
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
-
A
E
LA
E
L
I
K
R
G
E
M
T
A
A
V
--
I
A
V
---------
Q
---------------------------------
V
-
A
D
A
I
-
F
-
Q
S
---
G
-
S
G
-
A
R
I
I
F
L
G
D
L
V
R
D
G
-
E
P
Y
S
Y
G
P
P
I
E
D
P
Q
R
EPAQP
A
F
I
F
-
Y
--
T
S
--
T
G
L
P
K
AA
I
I
P
Q
R
A
A
E
S
R
V
L
F
M
S
T
Q
V
G
----
L
R
H
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
A
-
V
L
V
A
A
L
A
L
D
G
T
Y
V
V
-
V
E
E
--
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
--
A
A
A
H
A
G
S
-
S
L
K
L
--
D
S
L
R
H
V
T
F
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
H
L
-
P
G
E
K
V
N
G
Y
G
T
T
E
A
M
N
S
L
Y
M
R
Q
P
K
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
V
R
I
G
-
G
-
G
-
V
D
E
I
V
A
N
-----------
G
E
E
G
E
L
I
V
A
-----
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
-
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
-
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
L
G
E
-----
T
L
S
A
-
D
A
L
D
T
F
C
R
S
S
E
-
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
-----
16
PsiBlast_PDB
80.80
27%
-83
- C2 -
2QVX
1
?
X:
[4-501]
--------
V
N
E
M
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
P
A
---
R
G
L
R
L
-------
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
-
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
-
A
E
LA
E
L
I
K
R
G
E
M
T
A
A
V
--
I
A
V
-
G
R
------
Q
---------------------------------
V
-
A
D
A
I
-
F
-
Q
S
---
G
-
S
G
-
A
R
I
I
F
L
G
D
L
V
R
D
G
-
E
P
Y
S
Y
G
P
P
I
E
D
P
Q
R
EPAQP
A
F
I
F
-
Y
--
T
S
--
T
G
L
P
K
AA
I
I
P
Q
R
A
A
E
S
R
V
L
F
M
S
T
Q
V
G
----
L
R
H
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
A
-
V
L
V
A
A
L
A
L
D
G
T
Y
V
V
-
V
E
E
--
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
--
A
A
A
H
A
G
S
-
S
L
K
L
--
D
S
L
R
H
V
T
F
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
H
L
-
P
G
E
K
V
N
G
Y
G
T
T
E
A
M
N
S
L
Y
M
R
Q
P
K
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
V
R
I
G
-
G
-
G
-
V
D
E
I
V
A
N
-----------
G
E
E
G
E
L
I
V
A
-----
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
-
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
-
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
L
G
E
-----
T
L
S
A
-
D
A
L
D
T
F
C
R
S
S
E
-
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
-----
14
PsiBlast_PDB
80.79
27%
-84
- C2 -
2QVZ
1
?
X:
[4-501]
--------
V
N
E
M
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
P
A
---
R
G
L
R
L
-------
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
-
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
-
A
E
LA
E
L
I
K
R
G
E
M
T
A
A
V
--
I
A
V
---------
Q
---------------------------------
V
-
A
D
A
I
-
F
-
Q
S
---
G
-
S
G
-
A
R
I
I
F
L
G
D
L
V
R
D
G
-
E
P
Y
S
Y
G
P
P
I
E
D
P
Q
R
EPAQP
A
F
I
F
-
Y
--
T
S
---
G
L
P
K
AA
I
I
P
Q
R
A
A
E
S
R
V
L
F
M
S
T
Q
V
G
----
L
R
H
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
A
-
V
L
V
A
A
L
A
L
D
G
T
Y
V
V
-
V
E
E
--
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
--
A
A
A
H
A
G
S
-
S
L
K
L
--
D
S
L
R
H
V
T
F
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
H
L
-
P
G
E
K
V
N
A
Y
G
T
T
E
A
M
N
S
L
Y
M
R
Q
P
K
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
V
R
I
G
-
G
-
G
-
V
D
E
I
V
A
N
-----------
G
E
E
G
E
L
I
V
A
-----
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
-
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
-
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
L
G
E
-----
T
L
S
A
-
D
A
L
D
T
F
C
R
S
S
E
-
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
-----
11
PsiBlast_PDB
80.43
25%
-85
- C2 -
3A9U
-
?
A:
[39-533]
-----------------------
P
C
L
I
N
G
A
---
N
G
D
V
Y
-------
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
-
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
-
A
E
--
L
A
K
H
A
K
A
S
R
A
K
L
--
L
I
T
-
Q
A
-------
C
Y
Y
E
--------
K
---
V
K
D
---
F
--
A
R
--
E
-
D
V
K
-
V
-
M
C
-
V
-
D
S
---
A
P
D
G
----
C
L
H
F
S
E
L
T
Q
A
-
D
E
N
E
A
P
Q
V
D
I
S
P
D
D
-----
V
V
A
L
P
Y
--
S
S
G
T
T
G
L
P
K
--
G
V
M
L
T
H
K
G
L
I
T
S
V
A
Q
Q
V
D
G
DNPN
L
Y
F
H
S
E
D
V
I
L
C
V
L
P
M
F
H
I
Y
A
L
-
N
S
-
I
M
L
C
G
L
R
V
G
A
P
I
L
I
---
M
P
K
F
E
I
G
S
L
L
G
L
I
E
K
Y
K
V
S
I
A
P
V
V
P
P
V
M
M
S
I
------
A
K
S
P
D
-
L
D
K
H
DL
S
S
L
R
M
I
K
S
-------
E
L
E
D
T
V
R
A
K
F
P
Q
A
R
L
G
Q
G
Y
G
M
T
E
A
G
P
V
L
A
M
C
L
A
F
A
K
E
P
F
D
I
K
P
G
A
C
G
T
V
V
R
N
----
A
-
E
M
K
I
V
D
P
E
T
G
A
S
L
P
R
---
N
Q
P
G
E
I
C
I
R
-----
G
D
-
Q
I
M
K
G
Y
L
N
D
P
E
A
T
S
R
T
I
D
K
-
E
G
W
L
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
-
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
P
E
I
S
D
A
A
V
V
G
L
K
D
E
D
A
G
E
V
P
V
A
F
V
V
K
S
E
K
S
-----
Q
A
T
E
-
D
E
I
K
Q
Y
I
S
-
K
Q
-
V
I
F
Y
K
R
I
K
R
V
F
F
I
E
A
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
L
----
18
PsiBlast_PDB
79.85
27%
-83
- C2 -
1T5D
2
?
X:
[4-501]
--------
V
N
E
M
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
P
A
---
R
G
L
R
L
-------
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
-
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
-
A
E
LA
E
L
I
K
R
G
E
M
T
A
A
V
--
I
A
V
-
G
R
------
Q
---------------------------------
V
-
A
D
A
I
-
F
-
Q
S
---
G
-
S
G
-
A
R
I
I
F
L
G
D
L
V
R
D
G
-
E
P
Y
S
Y
G
P
P
I
E
D
P
Q
R
EPAQP
A
F
I
F
-
Y
--
T
S
--
T
G
L
P
K
AA
I
I
P
Q
R
A
A
E
S
R
V
L
F
M
S
T
Q
V
G
----
L
R
H
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
A
-
V
L
V
A
A
L
A
L
D
G
T
Y
V
V
-
V
E
E
--
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
--
A
A
A
H
A
G
S
-
S
L
K
L
--
D
S
L
R
H
V
T
F
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
H
L
-
P
G
E
K
V
N
I
Y
G
T
T
E
A
M
N
S
L
Y
M
R
Q
P
K
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
V
R
I
G
-
G
-
G
-
V
D
E
I
V
A
N
-----------
G
E
E
G
E
L
I
V
A
-----
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
-
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
-
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
L
G
E
-----
T
L
S
A
-
D
A
L
D
T
F
C
R
S
S
E
-
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
-----
41
HHSearch
78.98
25%
-88
- C2 -
4IZ6
2
ENTE_ECOLI
A:
[47-555]
--------
L
T
D
I
L
T
R
H
A
A
--
S
D
S
I
A
V
I
D
-----
G
E
R
Q
L
-------
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
-
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
-
S
E
--
L
N
A
Y
A
S
Q
I
E
P
A
L
--
L
I
A
-
D
R
------
Q
H
A
L
F
--------
S
---
G
D
D
---
F
--
L
N
--
T
F
V
T
E
-
H
S
S
I
R
V
-
V
Q
L
--
L
N
D
S
-
G
E
H
N
L
Q
D
A
I
-
N
H
P
-
A
E
D
F
T
A
T
P
S
P
A
D
E
V
-----
A
Y
F
Q
-
L
--
S
G
G
-
T
G
T
P
K
--
L
I
P
R
T
H
N
D
Y
Y
Y
S
V
R
R
S
V
E
I
----
C
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
Y
A
M
-
S
S
P
G
S
L
G
V
F
L
A
G
G
T
V
V
L
-
A
A
--
D
P
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
Q
--
A
L
I
E
G
E
S
-
R
A
Q
L
--
A
S
L
K
L
L
Q
V
G
G
A
R
L
S
A
T
L
A
A
R
I
P
A
E
I
-
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
L
V
N
Y
T
R
L
D
D
S
-------
A
E
K
I
I
H
T
Q
G
Y
P
M
C
P
-
D
D
E
V
W
V
A
D
A
E
-
G
N
P
L
P
Q
---
G
E
V
G
R
L
M
T
R
-----
G
P
-
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
-
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
-
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
E
K
S
C
A
Y
L
V
V
K
E
P
-------
L
R
A
-
V
Q
V
R
R
F
L
R
-
E
Q
G
I
A
E
F
K
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
---
22
PsiBlast_CBE
54.71
32%
-80
- C2 -
3NYQ
3
?
A:
[156-491]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
-----
A
L
V
V
-
Y
--
T
S
G
T
T
G
P
P
K
--
G
A
V
I
P
R
R
A
L
A
T
T
L
D
A
L
A
D
A
----
W
Q
W
T
G
E
D
V
L
V
Q
G
L
P
L
F
H
V
H
G
L
-
V
L
-
G
I
L
G
P
L
R
R
G
G
S
V
R
---
H
L
G
R
F
S
T
E
G
A
A
R
E
L
N
D
-
G
A
T
M
L
F
G
V
P
T
M
Y
H
R
I
A
E
--
T
L
P
A
D
P
E
L
A
K
A
L
--
A
G
A
R
L
L
V
S
G
S
A
A
L
P
V
H
D
H
E
R
I
A
A
A
T
-
G
R
R
V
I
E
R
Y
G
M
T
E
-
T
L
M
N
T
S
V
R
A
D
G
E
P
R
A
G
T
V
G
V
P
L
------
P
-
G
-
V
-
E
L
R
L
V
------
P
I
A
A
LDG
E
S
V
G
E
I
Q
V
R
-----
G
P
-
N
L
F
T
E
Y
L
N
R
P
D
A
T
A
A
A
F
-
T
E
D
G
F
F
R
T
G
D
M
A
V
R
D
P
D
G
Y
V
R
I
V
G
R
K
A
T
D
L
I
K
S
G
G
Y
K
I
G
A
G
E
I
E
N
A
L
L
E
H
P
E
V
R
E
A
A
V
T
G
E
P
D
P
D
L
G
E
R
I
V
A
W
I
V
P
A
D
P
A
-----
A
P
P
A
L
G
T
L
A
D
H
V
A
-
A
R
-
L
A
P
H
K
R
P
R
V
V
R
Y
L
D
A
V
P
R
-------------------
21
PsiBlast_CBE
53.60
32%
-79
- C2 -
3NYR
2
?
A:
[156-491]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
-----
A
L
V
V
-
Y
--
T
S
G
T
T
G
P
P
K
--
G
A
V
I
P
R
R
A
L
A
T
T
L
D
A
L
A
D
A
----
W
Q
W
T
G
E
D
V
L
V
Q
G
L
P
L
F
H
V
H
G
L
-
V
L
-
G
I
L
G
P
L
R
R
G
G
S
V
R
---
H
L
G
R
F
S
T
E
G
A
A
R
E
L
N
D
-
G
A
T
M
L
F
G
V
P
T
M
Y
H
R
I
A
E
--
T
L
P
A
D
P
E
L
A
K
A
L
--
A
G
A
R
L
L
V
S
G
S
A
A
L
P
V
H
D
H
E
R
I
A
A
A
T
-
G
R
R
V
I
E
R
Y
G
M
T
E
-
T
L
M
N
T
S
V
R
A
D
G
E
P
R
A
G
T
V
G
V
P
L
------
P
-
G
-
V
-
E
L
R
L
V
------
P
I
A
A
LDG
E
S
V
G
E
I
Q
V
R
-----
G
P
-
N
L
F
T
E
Y
L
N
R
P
D
A
T
A
A
A
F
-
T
E
D
G
F
F
R
T
G
D
M
A
V
R
D
P
D
G
Y
V
R
I
V
G
R
K
A
T
D
L
I
K
S
G
G
Y
K
I
G
A
G
E
I
E
N
A
L
L
E
H
P
E
V
R
E
A
A
V
T
G
E
P
D
P
D
L
G
E
R
I
V
A
W
I
V
P
A
D
P
A
-----
A
P
P
A
L
G
T
L
A
D
H
V
A
-
A
R
-
L
A
P
H
K
R
P
R
V
V
R
Y
L
D
A
V
P
R
-------------------