@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0233: (2016-04-20 )
MTRTRSGSLAAGGLNWASLPLKLFAGGNAKFWHPADIDFTRDRADWEKLSDDERDYATRLCTQFIAGEEAVTEDIQPFMSAMRAEGRLADEMYLTQFAFEEAKHTQVFRMWLDAVGISEDLHRYLDDLPAYRQIFYAELPECLNALSADPSPAAQVRASVTYNHIVEGMLALTGYYAWHKICVERAILPGMQELVRRIGDDERRHMAWGTFTCRRHVAADDANWTVFETRMNELIPLALRLIEEGFALYGDQPPFDLSKDDFLQYSTDKGMRRFGTISNARGRPVAEIDVDYSPAQLEDTFADEDRRTLAAASA
Atome Classification :
(20 SA)
.........10........----20...--....-.30.........40........50........60........70......-..80........90........100.......110.......---120--.........130....-...140.....---..150.......160.......170.......180.......190.......200.......210.......220----.-----.......230.....-..240.......250----.--------........260.......270.......280...------....290.......300.......310..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTRTRSGSLAAGGLNWASL----
P
L
K
L
F
--AGGN-A
K
-
F
WHPADIDFTRDRA
D
W
E
KLSD
D
E
R
D
Y
A
T
R
L
C
T
Q
F
IAG
E
E
A
V
T
E
D
I
Q
P
-
F
M
S
A
M
R
AEGRL
A
D
E
M
Y
L
T
Q
F
A
F
E
E
A
K
H
T
Q
V
F
R
M
W
L
D
AVG
I
S
E
---
D
----
L
H
R
Y
L
D
D
L
P
A
Y
R
Q
I
F
Y
-
A
E
L
P
E
C
L
N
A
LS---ADPS
P
A
A
Q
V
R
A
S
V
T
Y
N
H
I
V
E
G
M
L
A
L
T
G
Y
Y
A
W
H
K
I
C
V
E
R
A
I
L
P
G
M
Q
E
L
V
R
RIGDD
E
R
R
H
M
A
W
G
T
F
T
C
RRHVAADD-----A-----
N
W
T
V
F
E
T
R
M
N
E
L
I
P
L
-
A
L
R
L
I
E
E
G
F
A
LYG------D--------QPPFDL
S
K
D
D
F
LQYSTD
K
G
M
R
R
FGTISNARGR
P
V
------
A
E
I
DVDYSP
A
Q
L
E
D
TFADED
R
R
TLAAASA
21
PsiBlast_CBE
97.53
100%
-94
- C3 -
4AC8
3
RIR2H_MYCTU
D:
[11-320]
-
T
R
T
R
S
G
S
L
A
A
G
G
L
N
W
A
S
L
----
P
L
K
L
F
--
A
G
G
N
-
A
K
-
F
W
H
P
A
D
I
D
F
T
R
D
R
A
D
W
E
K
L
S
D
D
E
R
D
Y
A
T
R
L
C
T
Q
F
I
A
G
E
E
A
V
T
E
D
I
Q
P
-
F
M
S
A
M
R
A
E
G
R
L
A
D
E
M
Y
L
T
Q
F
A
F
E
E
A
K
H
T
Q
V
F
R
M
W
L
D
A
V
G
I
S
E
---
D
----
L
H
R
Y
L
D
D
L
P
A
Y
R
Q
I
F
Y
-
A
E
L
P
E
C
L
N
A
L
S
---
A
D
P
S
P
A
A
Q
V
R
A
S
V
T
Y
N
H
I
V
E
G
M
L
A
L
T
G
Y
Y
A
W
H
K
I
C
V
E
R
A
I
L
P
G
M
Q
E
L
V
R
R
I
G
D
D
E
R
R
H
M
A
W
G
T
F
T
C
R
R
H
V
A
A
D
D
-----
A
-----
N
W
T
V
F
E
T
R
M
N
E
L
I
P
L
-
A
L
R
L
I
E
E
G
F
A
L
Y
G
------
D
--------
Q
P
P
F
D
L
S
K
D
D
F
L
Q
Y
S
T
D
K
G
M
R
R
F
G
T
I
S
N
A
R
G
R
P
V
------
A
E
I
D
V
D
Y
S
P
A
Q
L
E
D
T
F
A
D
E
D
R
R
T
L
A
A
---
22
PsiBlast_CBE
97.01
100%
-93
- C3 -
4AC8
4
RIR2H_MYCTU
C:
[11-319]
-
T
R
T
R
S
G
S
L
A
A
G
G
L
N
W
A
S
L
----
P
L
K
L
F
--
A
G
G
N
-
A
K
-
F
W
H
P
A
D
I
D
F
T
R
D
R
A
D
W
E
K
L
S
D
D
E
R
D
Y
A
T
R
L
C
T
Q
F
I
A
G
E
E
A
V
T
E
D
I
Q
P
-
F
M
S
A
M
R
A
E
G
R
L
A
D
E
M
Y
L
T
Q
F
A
F
E
E
A
K
H
T
Q
V
F
R
M
W
L
D
A
V
G
I
S
E
---
D
----
L
H
R
Y
L
D
D
L
P
A
Y
R
Q
I
F
Y
-
A
E
L
P
E
C
L
N
A
L
S
---
A
D
P
S
P
A
A
Q
V
R
A
S
V
T
Y
N
H
I
V
E
G
M
L
A
L
T
G
Y
Y
A
W
H
K
I
C
V
E
R
A
I
L
P
G
M
Q
E
L
V
R
R
I
G
D
D
E
R
R
H
M
A
W
G
T
F
T
C
R
R
H
V
A
A
D
D
-----
A
-----
N
W
T
V
F
E
T
R
M
N
E
L
I
P
L
-
A
L
R
L
I
E
E
G
F
A
L
Y
G
------
D
--------
Q
P
P
F
D
L
S
K
D
D
F
L
Q
Y
S
T
D
K
G
M
R
R
F
G
T
I
S
N
A
R
G
R
P
V
------
A
E
I
D
V
D
Y
S
P
A
Q
L
E
D
T
F
A
D
E
D
R
R
T
L
A
----
2
PsiBlast_PDB
96.76
100%
-93
- C3 -
4AC8
5
RIR2H_MYCTU
A:
[11-321]
-
T
R
T
R
S
G
S
L
A
A
G
G
L
N
W
A
S
L
----
P
L
K
L
F
--
A
G
G
N
-
A
K
-
F
W
H
P
A
D
I
D
F
T
R
D
R
A
D
W
E
K
L
S
D
D
E
R
D
Y
A
T
R
L
C
T
Q
F
I
A
G
E
E
A
V
T
E
D
I
Q
P
-
F
M
S
A
M
R
A
E
G
R
L
A
D
E
M
Y
L
T
Q
F
A
F
E
E
A
K
H
T
Q
V
F
R
M
W
L
D
A
V
G
I
S
E
---
D
----
L
H
R
Y
L
D
D
L
P
A
Y
R
Q
I
F
Y
-
A
E
L
P
E
C
L
N
A
L
S
---
A
D
P
S
P
A
A
Q
V
R
A
S
V
T
Y
N
H
I
V
E
G
M
L
A
L
T
G
Y
Y
A
W
H
K
I
C
V
E
R
A
I
L
P
G
M
Q
E
L
V
R
R
I
G
D
D
E
R
R
H
M
A
W
G
T
F
T
C
R
R
H
V
A
A
D
D
-----
A
-----
N
W
T
V
F
E
T
R
M
N
E
L
I
P
L
-
A
L
R
L
I
E
E
G
F
A
L
Y
G
------
D
--------
Q
P
P
F
D
L
S
K
D
D
F
L
Q
Y
S
T
D
K
G
M
R
R
F
G
T
I
S
N
A
R
G
R
P
V
------
A
E
I
D
V
D
Y
S
P
A
Q
L
E
D
T
F
A
D
E
D
R
R
T
L
A
A
A
--
1
PsiBlast_PDB
96.04
100%
-100
- C3 -
3EE4
3
RIR2H_MYCTU
A:
[11-299]
-
T
R
T
R
S
G
S
L
A
A
G
G
L
N
W
A
S
L
----
P
L
K
L
F
--
A
G
G
N
-
A
K
-
F
W
H
P
A
D
I
D
F
T
R
D
R
A
D
W
E
K
L
S
D
D
E
R
D
Y
A
T
R
L
C
T
Q
F
I
A
G
E
E
A
V
T
E
D
I
Q
P
-
F
M
S
A
M
R
A
E
G
R
L
A
D
E
M
Y
L
T
Q
F
A
F
E
E
A
K
H
T
Q
V
F
R
M
W
L
D
A
V
G
I
S
E
---
D
----
L
H
R
Y
L
D
D
L
P
A
Y
R
Q
I
F
Y
-
A
E
L
P
E
C
L
N
A
L
S
---
A
D
P
S
P
A
A
Q
V
R
A
S
V
T
Y
N
H
I
V
E
G
M
L
A
L
T
G
Y
Y
A
W
H
K
I
C
V
E
R
A
I
L
P
G
M
Q
E
L
V
R
R
I
G
D
D
E
R
R
H
M
A
W
G
T
F
T
C
R
R
H
V
A
A
D
D
-----
A
-----
N
W
T
V
F
E
T
R
M
N
E
L
I
P
L
-
A
L
R
L
I
E
E
G
F
A
L
Y
G
------
D
--------
Q
P
P
F
D
L
S
K
D
D
F
L
Q
Y
S
T
D
K
G
M
R
R
F
G
T
I
S
N
A
R
G
R
P
V
------
A
E
I
D
V
------------------------
23
PsiBlast_CBE
95.83
100%
-91
- C3 -
4AC8
4
RIR2H_MYCTU
B:
[11-319]
-
T
R
T
R
S
G
S
L
A
A
G
G
L
N
W
A
S
L
----
P
L
K
L
F
--
A
G
G
N
-
A
K
-
F
W
H
P
A
D
I
D
F
T
R
D
R
A
D
W
E
K
L
S
D
D
E
R
D
Y
A
T
R
L
C
T
Q
F
I
A
G
E
E
A
V
T
E
D
I
Q
P
-
F
M
S
A
M
R
A
E
G
R
L
A
D
E
M
Y
L
T
Q
F
A
F
E
E
A
K
H
T
Q
V
F
R
M
W
L
D
A
V
G
I
S
E
---
D
----
L
H
R
Y
L
D
D
L
P
A
Y
R
Q
I
F
Y
-
A
E
L
P
E
C
L
N
A
L
S
---
A
D
P
S
P
A
A
Q
V
R
A
S
V
T
Y
N
H
I
V
E
G
M
L
A
L
T
G
Y
Y
A
W
H
K
I
C
V
E
R
A
I
L
P
G
M
Q
E
L
V
R
R
I
G
D
D
E
R
R
H
M
A
W
G
T
F
T
C
R
R
H
V
A
A
D
D
-----
A
-----
N
W
T
V
F
E
T
R
M
N
E
L
I
P
L
-
A
L
R
L
I
E
E
G
F
A
L
Y
G
------
D
--------
Q
P
P
F
D
L
S
K
D
D
F
L
Q
Y
S
T
D
K
G
M
R
R
F
G
T
I
S
N
A
R
G
R
P
V
------
A
E
I
D
V
D
Y
S
P
A
Q
L
E
D
T
F
A
D
E
D
R
R
T
L
A
----
25
HHSearch
75.08
84%
-80
- C3 -
3EE4
3
RIR2H_MYCTU
A:
[11-299]
-
T
R
T
R
S
G
S
L
A
A
G
G
L
N
W
A
S
L
----
P
L
K
L
F
--
A
G
G
N
-
A
K
-
F
W
H
P
A
D
I
D
F
T
R
D
R
A
D
W
E
K
L
S
D
D
E
R
D
Y
A
T
R
L
C
T
Q
F
I
A
G
E
E
A
V
T
E
D
I
Q
P
-
F
M
S
A
M
R
A
E
G
R
L
A
D
E
M
Y
L
T
Q
F
A
F
E
E
A
K
H
T
Q
V
F
R
M
W
L
D
A
V
G
I
S
E
---
D
L---
H
R
Y
L
D
-
D
L
P
A
Y
R
-
Q
I
F
Y
A
E
L
P
E
C
L
N
A
L
S
---
A
D
P
S
P
A
A
Q
V
R
A
S
V
T
Y
N
H
I
V
E
G
M
L
A
L
T
G
Y
Y
A
W
H
K
I
C
V
E
R
A
I
L
P
G
M
Q
E
L
V
R
R
I
G
D
D
E
R
R
H
M
A
W
G
T
F
T
C
R
R
H
V
A
A
D
D
-----
A
N
W
T
V
-
F
E
T
R
M
N
E
L
I
P
L
A
L
R
L
I
E
E
G
F
A
L
Y
G
D
---
Q
------
P
--------
P
--
F
D
L
S
K
D
D
F
L
Q
---
Y
S
T
D
K
G
M
R
R
F
G
T
I
S
N
A
R
G
RP
V
---
A
E
I
D
V
------------------------
26
HHSearch
71.89
35%
-92
- C3 -
4XB9
3
?
A:
[22-300]
-------
Q
T
V
K
A
T
I
D
W
E
H
P
----
M
F
K
L
Y
--
E
K
A
K
R
N
G
-
K
W
N
P
A
D
I
D
F
S
Q
D
Q
K
D
F
A
S
L
T
S
E
E
K
I
S
A
L
P
L
V
A
G
F
S
A
G
E
E
A
V
T
L
D
I
L
P
-
M
A
H
A
L
A
R
Q
G
R
L
E
D
V
L
F
L
T
T
F
M
H
D
E
A
K
H
V
E
M
F
S
R
W
Q
Q
A
V
G
I
G
Q
M--
D
----
L
S
V
F
H
--
N
D
H
Y
K
R
I
F
Y
-
E
A
L
P
E
A
M
N
R
L
Y
---
A
D
D
S
P
E
A
V
I
R
A
A
T
V
Y
N
M
I
V
E
G
T
L
A
E
S
G
Y
Y
T
F
R
Q
I
Y
K
K
A
G
L
F
P
G
L
L
Q
G
I
D
Y
L
N
M
D
E
G
R
H
I
Q
F
G
I
Y
T
I
Q
R
I
V
N
E
D
E
-----
R
-----
Y
Y
E
L
F
I
R
Y
M
D
E
L
W
P
H
-
V
I
G
Y
V
D
Y
L
T
E
L
G
K
------
R
Q
Q
Q
L
A
R
T
Y
A
L
--
E
I
D
Y
D
L
L
R
H
Y
V
I
K
Q
F
N
L
R
K
K
Q
I
S
R
T
----------------------------------------
46
Fugue
69.73
34%
-85
- C3 -
4HR0
5
?
A:
[16-301]
-
V
H
H
D
G
F
Q
T
V
K
A
T
I
D
W
E
H
P
----
M
F
K
L
Y
--
E
K
A
K
-
R
N
G
K
W
N
P
A
D
I
D
F
S
Q
D
Q
K
D
F
A
S
L
T
S
E
E
K
I
S
A
L
P
L
V
A
G
F
S
A
G
E
E
A
V
T
L
D
I
L
P
-
M
A
H
A
L
A
R
Q
G
R
L
E
D
V
L
F
L
T
T
F
M
H
D
E
A
K
H
V
E
M
F
S
R
W
Q
Q
A
V
G
I
G
Q
---
M
----
D
L
S
V
F
H
N
-
D
H
Y
K
R
I
F
Y
-
E
A
L
P
E
A
M
N
R
L
Y
---
A
D
D
S
P
E
A
V
I
R
A
A
T
V
Y
N
M
I
V
E
G
T
L
A
E
S
G
Y
Y
T
F
R
Q
I
Y
K
K
A
G
L
F
P
G
L
L
Q
G
I
D
Y
L
N
M
D
E
G
R
H
I
Q
F
G
I
Y
T
I
Q
R
I
V
N
E
D
E
-----
R
-----
Y
Y
E
L
F
I
R
Y
M
D
E
L
W
P
H
-
V
I
G
Y
V
D
Y
L
T
E
L
G
K
R
Q
Q
Q
L
A
R
--------
T
Y
A
L
E
I
D
Y
D
L
L
R
H
Y
V
I
K
Q
F
N
L
R
K
K
Q
I
S
R
T
K
---------------------------------------
5
PsiBlast_PDB
67.11
42%
-99
- C3 -
4HR5
1
?
A:
[28-250]
-------------
I
D
W
E
H
P
----
M
F
K
L
Y
E
K
A
K
R
N
-
G
K
--
W
N
P
A
D
I
D
F
S
Q
D
Q
K
D
F
A
S
L
T
S
E
E
K
I
S
A
L
P
L
V
A
G
F
S
A
G
----
T
L
D
I
L
P
-
M
A
H
A
L
A
R
Q
G
R
L
E
D
V
L
F
L
T
T
F
M
H
D
E
A
K
H
V
E
M
F
S
R
W
Q
Q
A
V
G
I
G
Q
M--
D
----
L
S
V
F
H
N
D
--
H
Y
K
R
I
F
Y
-
E
A
L
P
E
A
M
N
R
L
Y
---
A
D
D
S
P
E
A
V
I
R
A
A
T
V
Y
N
M
I
V
E
G
T
L
A
E
S
G
Y
Y
T
F
R
Q
I
Y
K
K
A
G
L
F
P
G
L
L
Q
G
I
D
Y
L
N
M
D
E
G
R
H
I
Q
F
G
I
Y
T
I
Q
R
I
V
N
E
D
E
-----
R
-----
Y
Y
E
L
F
I
R
Y
M
D
E
L
W
P
---------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
67.07
42%
-98
- C3 -
4XB9
3
?
A:
[28-250]
-------------
I
D
W
E
H
P
----
M
F
K
L
Y
E
K
A
K
R
N
-
G
K
--
W
N
P
A
D
I
D
F
S
Q
D
Q
K
D
F
A
S
L
T
S
E
E
K
I
S
A
L
P
L
V
A
G
F
S
A
G
E
E
A
V
T
L
D
I
L
P
-
M
A
H
A
L
A
R
Q
G
R
L
E
D
V
L
F
L
T
T
F
M
H
D
E
A
K
H
V
E
M
F
S
R
W
Q
Q
A
V
G
I
G
Q
M--
D
----
L
S
V
F
H
N
D
--
H
Y
K
R
I
F
Y
-
E
A
L
P
E
A
M
N
R
L
Y
---
A
D
D
S
P
E
A
V
I
R
A
A
T
V
Y
N
M
I
V
E
G
T
L
A
E
S
G
Y
Y
T
F
R
Q
I
Y
K
K
A
G
L
F
P
G
L
L
Q
G
I
D
Y
L
N
M
D
E
G
R
H
I
Q
F
G
I
Y
T
I
Q
R
I
V
N
E
D
E
-----
R
-----
Y
Y
E
L
F
I
R
Y
M
D
E
L
W
P
---------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
66.65
42%
-95
- C3 -
5DCO
3
?
A:
[28-250]
-------------
I
D
W
E
H
P
----
M
F
K
L
Y
E
K
A
K
R
N
-
G
K
--
W
N
P
A
D
I
D
F
S
Q
D
Q
K
D
F
A
S
L
T
S
E
E
K
I
S
A
L
P
L
V
A
G
F
S
A
G
E
E
A
V
T
L
D
I
L
P
-
M
A
H
A
L
A
R
Q
G
R
L
E
D
V
L
F
L
T
T
F
M
H
D
E
A
K
H
V
E
M
F
S
R
W
Q
Q
A
V
G
I
G
Q
M--
D
----
L
S
V
F
H
N
D
--
H
Y
K
R
I
F
Y
-
E
A
L
P
E
A
M
N
R
L
Y
---
A
D
D
S
P
E
A
V
I
R
A
A
T
V
Y
N
M
I
V
E
G
T
L
A
E
S
G
Y
Y
T
F
R
Q
I
Y
K
K
A
G
L
F
P
G
L
L
Q
G
I
D
Y
L
N
M
D
E
G
R
H
I
Q
F
G
I
Y
T
I
Q
R
I
V
N
E
D
E
-----
R
-----
Y
Y
E
L
F
I
R
Y
M
D
E
L
W
P
---------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
66.25
42%
-99
- C3 -
4HR0
5
?
A:
[28-250]
-------------
I
D
W
E
H
P
----
M
F
K
L
Y
E
K
A
K
R
N
-
G
K
--
W
N
P
A
D
I
D
F
S
Q
D
Q
K
D
F
A
S
L
T
S
E
E
K
I
S
A
L
P
L
V
A
G
F
S
A
G
E
E
A
V
T
L
D
I
L
P
-
M
A
H
A
L
A
R
Q
G
R
L
E
D
V
L
F
L
T
T
F
M
H
D
E
A
K
H
V
E
M
F
S
R
W
Q
Q
A
V
G
I
G
Q
M--
D
----
L
S
V
F
H
N
D
--
H
Y
K
R
I
F
Y
-
E
A
L
P
E
A
M
N
R
L
Y
---
A
D
D
S
P
E
A
V
I
R
A
A
T
V
Y
N
M
I
V
E
G
T
L
A
E
S
G
Y
Y
T
F
R
Q
I
Y
K
K
A
G
L
F
P
G
L
L
Q
G
I
D
Y
L
N
M
D
E
G
R
H
I
Q
F
G
I
Y
T
I
Q
R
I
V
N
E
D
E
-----
R
-----
Y
Y
E
L
F
I
R
Y
M
D
E
L
W
P
---------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
65.80
42%
-96
- C3 -
4HR4
4
?
A:
[28-250]
-------------
I
D
W
E
H
P
----
M
F
K
L
Y
E
K
A
K
R
N
-
G
K
--
W
N
P
A
D
I
D
F
S
Q
D
Q
K
D
F
A
S
L
T
S
E
E
K
I
S
A
L
P
L
V
A
G
F
S
A
G
E
E
A
V
T
L
D
I
L
P
-
M
A
H
A
L
A
R
Q
G
R
L
E
D
V
L
F
L
T
T
F
M
H
D
E
A
K
H
V
E
M
F
S
R
W
Q
Q
A
V
G
I
G
Q
M--
D
----
L
S
V
F
H
N
D
--
H
Y
K
R
I
F
Y
-
E
A
L
P
E
A
M
N
R
L
Y
---
A
D
D
S
P
E
A
V
I
R
A
A
T
V
Y
N
M
I
V
E
G
T
L
A
E
S
G
Y
Y
T
F
R
Q
I
Y
K
K
A
G
L
F
P
G
L
L
Q
G
I
D
Y
L
N
M
D
E
G
R
H
I
Q
F
G
I
Y
T
I
Q
R
I
V
N
E
D
E
-----
R
-----
Y
Y
E
L
F
I
R
Y
M
D
E
L
W
P
---------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
65.71
42%
-95
- C3 -
5DCS
4
?
A:
[28-250]
-------------
I
D
W
E
H
P
----
M
F
K
L
Y
E
K
A
K
R
N
-
G
K
--
W
N
P
A
D
I
D
F
S
Q
D
Q
K
D
F
A
S
L
T
S
E
E
K
I
S
A
L
P
L
V
A
G
F
S
A
G
E
E
A
V
T
L
D
I
L
P
-
M
A
H
A
L
A
R
Q
G
R
L
E
D
V
L
F
L
T
T
F
M
H
D
E
A
K
H
V
E
M
F
S
R
W
Q
Q
A
V
G
I
G
Q
M--
D
----
L
S
V
F
H
N
D
--
H
Y
K
R
I
F
Y
-
E
A
L
P
E
A
M
N
R
L
Y
---
A
D
D
S
P
E
A
V
I
R
A
A
T
V
Y
N
M
I
V
E
G
T
L
A
E
S
G
Y
Y
T
F
R
Q
I
Y
K
K
A
G
L
F
P
G
L
L
Q
G
I
D
Y
L
N
M
D
E
G
R
H
I
Q
F
G
I
Y
T
I
Q
R
I
V
N
E
D
E
-----
R
-----
Y
Y
E
L
F
I
R
Y
M
D
E
L
W
P
---------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
65.46
42%
-94
- C3 -
5DCR
4
?
A:
[28-250]
-------------
I
D
W
E
H
P
----
M
F
K
L
Y
E
K
A
K
R
N
-
G
K
--
W
N
P
A
D
I
D
F
S
Q
D
Q
K
D
F
A
S
L
T
S
E
E
K
I
S
A
L
P
L
V
A
G
F
S
A
G
E
E
A
V
T
L
D
I
L
P
-
M
A
H
A
L
A
R
Q
G
R
L
E
D
V
L
F
L
T
T
F
M
H
D
E
A
K
H
V
E
M
F
S
R
W
Q
Q
A
V
G
I
G
Q
M--
D
----
L
S
V
F
H
N
D
--
H
Y
K
R
I
F
Y
-
E
A
L
P
E
A
M
N
R
L
Y
---
A
D
D
S
P
E
A
V
I
R
A
A
T
V
Y
N
M
I
V
E
G
T
L
A
E
S
G
Y
Y
T
F
R
Q
I
Y
K
K
A
G
L
F
P
G
L
L
Q
G
I
D
Y
L
N
M
D
E
G
R
H
I
Q
F
G
I
Y
T
I
Q
R
I
V
N
E
D
E
-----
R
-----
Y
Y
E
L
F
I
R
Y
M
D
E
L
W
P
---------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
65.32
42%
-95
- C3 -
4XBV
4
?
A:
[28-250]
-------------
I
D
W
E
H
P
----
M
F
K
L
Y
E
K
A
K
R
N
-
G
K
--
W
N
P
A
D
I
D
F
S
Q
D
Q
K
D
F
A
S
L
T
S
E
E
K
I
S
A
L
P
L
V
A
G
F
S
A
G
E
E
A
V
T
L
D
I
L
P
-
M
A
H
A
L
A
R
Q
G
R
L
E
D
V
L
F
L
T
T
F
M
H
D
E
A
K
H
V
E
M
F
S
R
W
Q
Q
A
V
G
I
G
Q
M--
D
----
L
S
V
F
H
N
D
--
H
Y
K
R
I
F
Y
-
E
A
L
P
E
A
M
N
R
L
Y
---
A
D
D
S
P
E
A
V
I
R
A
A
T
V
Y
N
M
I
V
E
G
T
L
A
E
S
G
Y
Y
T
F
R
Q
I
Y
K
K
A
G
L
F
P
G
L
L
Q
G
I
D
Y
L
N
M
D
E
G
R
H
I
Q
F
G
I
Y
T
I
Q
R
I
V
N
E
D
E
-----
R
-----
Y
Y
E
L
F
I
R
Y
M
D
E
L
W
P
---------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
65.20
42%
-94
- C3 -
4XBV
4
?
B:
[28-250]
-------------
I
D
W
E
H
P
----
M
F
K
L
Y
EK
A
K
R
N
-
G
K
--
W
N
P
A
D
I
D
F
S
Q
D
Q
K
D
F
A
S
L
T
S
E
E
K
I
S
A
L
P
L
V
A
G
F
S
A
G
E
E
A
V
T
L
D
I
L
P
-
M
A
H
A
L
A
R
Q
G
R
L
E
D
V
L
F
L
T
T
F
M
H
D
E
A
K
H
V
E
M
F
S
R
W
Q
Q
A
V
G
I
G
Q
M--
D
----
L
S
V
F
H
N
D
--
H
Y
K
R
I
F
Y
-
E
A
L
P
E
A
M
N
R
L
Y
---
A
D
D
S
P
E
A
V
I
R
A
A
T
V
Y
N
M
I
V
E
G
T
L
A
E
S
G
Y
Y
T
F
R
Q
I
Y
K
K
A
G
L
F
P
G
L
L
Q
G
I
D
Y
L
N
M
D
E
G
R
H
I
Q
F
G
I
Y
T
I
Q
R
I
V
N
E
D
E
-----
R
-----
Y
Y
E
L
F
I
R
Y
M
D
E
L
W
P
---------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.59
42%
-93
- C3 -
4XBW
4
?
A:
[28-250]
-------------
I
D
W
E
H
P
----
M
F
K
L
Y
E
K
A
K
R
N
-
G
K
--
W
N
P
A
D
I
D
F
S
Q
D
Q
K
D
F
A
S
L
T
S
E
E
K
I
S
A
L
P
L
V
A
G
F
S
A
G
E
E
A
V
T
L
D
I
L
P
-
M
A
H
A
L
A
R
Q
G
R
L
E
D
V
L
F
L
T
T
F
M
H
D
E
A
K
H
V
E
M
F
S
R
W
Q
Q
A
V
G
I
G
Q
M--
D
----
L
S
V
F
H
N
D
--
H
Y
K
R
I
F
Y
-
E
A
L
P
E
A
M
N
R
L
Y
---
A
D
D
S
P
E
A
V
I
R
A
A
T
V
Y
N
M
I
V
E
G
T
L
A
E
S
G
Y
Y
T
F
R
Q
I
Y
K
K
A
G
L
F
P
G
L
L
Q
G
I
D
Y
L
N
M
D
E
G
R
H
I
Q
F
G
I
Y
T
I
Q
R
I
V
N
E
D
E
-----
R
-----
Y
Y
E
L
F
I
R
Y
M
D
E
L
W
P
---------------------------------------------------------------------------------------------------
40
HHSearch
50.43
15%
-73
- C3 -
3MJO
2
?
A:
[12-283]
-------
T
D
P
V
K
A
I
N
W
N
V
I
PD
E
K
D
L
E
V
W
--
D
R
L
T
-
G
N
-
F
W
L
P
E
K
I
P
V
S
N
D
I
Q
S
W
N
K
M
T
P
Q
E
Q
L
A
T
M
R
V
F
T
G
L
T
L
L
D
T
I
Q
G
T
V
G
A
I
S
L
L
P
D
A
E
T
---
M
H
E
E
A
V
Y
T
N
I
A
F
M
E
S
V
H
A
K
S
Y
S
N
I
F
M
T
L
A
S
T
P
---
Q
I
N
E
A
F
R
W
S
E
-
E
N
E
N
L
Q
-----
R
K
A
K
I
I
M
S
Y
Y
N
---
G
D
-
D
P
---
L
K
K
-
K
V
A
S
T
L
L
E
S
F
L
F
Y
S
G
F
Y
L
P
M
Y
L
-
S
S
R
A
K
L
T
N
T
A
D
I
I
R
L
I
I
R
D
E
S
V
H
G
Y
Y
I
G
Y
K
Y
Q
Q
G
V
K
K
L
S
E
A
E
Q
E
E
-----
Y
K
A
Y
T
F
D
L
M
Y
D
L
Y
E
N
-
E
I
E
Y
T
E
D
I
Y
D
--
D
----------------
L
--
G
W
T
-
E
D
V
K
R
F
L
R
Y
N
A
N
K
A
L
N
N
L
G
Y
E
G
L
F
P
T
------
D
----------------------------
32
HHSearch
49.94
14%
-70
- C3 -
2RCC
6
RIR2_BACHD
A:
[25-313]
-------
G
K
S
S
N
V
L
N
W
D
D
V
RFSW
A
Y
P
L
Y
--
K
N
M
L
-
A
N
-
F
W
T
P
F
E
I
N
M
S
H
D
A
K
Q
F
P
T
L
T
E
T
E
Q
E
A
F
K
K
I
I
G
L
L
A
F
L
D
S
V
Q
T
D
Y
S
M
R
-
A
A
E
Y
L
T
D
---
S
S
L
A
A
L
M
S
V
L
S
F
Q
E
V
V
H
N
Q
S
Y
S
Y
V
L
S
S
L
V
P
K
A
T
Q
D
E
I
---
F
E
Y
W
K
-
H
D
D
V
L
K
-----
E
R
N
E
F
I
I
D
G
Y
E
K
F
V
D
N
P
T
P
K
T
F
L
E
S
-
I
V
Y
D
V
I
L
E
G
L
N
F
Y
S
G
F
A
F
F
Y
N
L
-
A
R
N
Q
K
M
V
S
T
S
T
M
I
N
Y
I
N
R
D
E
Q
L
H
V
Y
L
F
T
N
I
F
K
E
L
L
V
E
F
P
-----
E
LNT
E
E
T
K
T
F
V
K
T
T
L
M
K
A
A
D
L
-
E
K
D
W
F
R
Y
I
I
G
--
D
------
K
--------
I
P
--
G
I
N
P
E
D
M
E
T
Y
I
S
F
I
A
N
K
R
A
V
Q
L
G
M
E
K
P
Y
P
E
IKHNPM
K
W
I
--------------------------