@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0242c: (2016-04-20 )
MAPKRSSDLFSQVVNSGPGSFLARQLGVPQPETLRRYRAGEPPLTGSLLIGGAGRVVEPLRAALEKDYDLVGNNLGGRWADSFGGLVFDATGITEPAGLKGLHEFFTPVLRNLGRCGRVVVVGGTPEAAASTNERIAQRALEGFTRSLGKELRRGATTALVYLSPDAKPAATGLESTMRFLLSAKSAYVDGQVFSVGADDSTPPADWEKPLDGKVAIVTGAARGIGATIAEVFARDGAHVVAIDVESAAENLAETASKVGGTALWLDVTADDAVDKISEHLRDHHGGKADILVNNAGITRDKLLANMDDARWDAVLAVNLLAPLRLTEGLVGNGSIGEGGRVIGLSSIAGIAGNRGQTNYATTKAGMIGITQALAPGLAAKGITINAVAPGFIETQMTAAIPLATREVGRRLNSLLQGGQPVDVAEAIAYFASPASNAVTGNVIRVCGQAMIGA
Atome Classification :
(36 SA)
.........10........20........30........40........50........60....-....70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......-210.......220.......230.......240...--.-...250...--....260.--......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400------........410.......420.......430.......440.......450..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAPK
R
S
S
D
L
F
S
Q
V
V
NSG
P
G
S
F
L
A
R
QLGVP
Q
P
E
T
L
R
R
YRAGEPPLT
G
S
L
L
IGGA
G
R
V
V
E
P
L
R
A
A
L
E
-
K
D
Y
D
L
VGNNLGGR
W
A
D
SFG
G
L
V
F
DATGITE
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
LGRCG
R
V
V
V
VGGTPEAAAS
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
RRGA
T
T
A
L
V
Y
LSPDAKPAAT
G
L
E
S
T
M
R
F
L
L
S
A
K
SAYVD
G
Q
V
F
S
VGADDSTPPADWEK-PLDG
K
V
A
I
V
TGAAR
G
I
G
A
T
I
A
E
V
F
A
RDG
A
H
V
V
A
I
D
V
--
E
-
S
A
A
E
N
L
A
E
T
--
A
S
KVGG
T
A
--
L
W
L
D
VTA
D
D
A
V
D
K
I
S
E
H
L
R
D
HHGGK
A
D
I
L
V
NNAGI
T
R
D
K
L
L
ANMDDARW
D
A
V
L
A
V
N
LLA
P
L
R
LTEGLVGNGSIGEG
G
R
V
I
G
L
S
S
I
A
GIAGNRGQT
N
Y
A
TTKA
G
M
I
G
I
T
Q
A
LAPGLAAK
G
I
T
I
NAVAP
G
F
I
E
TQ
M
T
AAI-------P
L
A
T
R
E
V
G
R
R
L
N
S
L
LQGGQPV
D
V
A
E
A
I
A
Y
FASPASNAV
T
G
N
V
I
R
V
C
G
Q
A
MIGA
2
PsiBlast_PDB
96.37
100%
-99
- C2 -
4FW8
2
?
A:
[20-454]
-------------------
S
F
L
A
R
Q
L
G
V
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
-
K
D
Y
D
L
V
G
--------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
P
D
A
K
P
A
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
D
S
T
P
P
A
D
W
E
K
-
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
--
E
-
S
A
A
E
N
L
A
E
T
--
A
S
K
V
G
G
T
A
--
L
W
L
D
V
T
A
D
D
A
V
D
K
I
S
E
H
L
R
D
H
H
G
G
K
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
Q
M
T
A
A
I
-------
P
L
A
T
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
5
PsiBlast_PDB
95.67
100%
-99
- C2 -
3Q6I
2
?
A:
[12-446]
-------------------
S
F
L
A
R
Q
L
G
V
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
-
K
D
Y
D
L
V
G
--------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
P
D
A
K
P
A
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
D
S
T
P
P
A
D
W
E
K
-
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
--
E
-
S
A
A
E
N
L
A
E
T
--
A
S
K
V
G
G
T
A
--
L
W
L
D
V
T
A
D
D
A
V
D
K
I
S
E
H
L
R
D
H
H
G
G
K
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
Q
M
T
A
A
I
-------
P
L
A
T
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
3
PsiBlast_PDB
94.57
100%
-100
- C2 -
3V1T
-
?
C:
[29-454]
----------------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
-
K
D
Y
D
L
V
---------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
P
D
A
K
P
A
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
D
S
T
P
P
A
D
W
E
K
-
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
--
E
-
S
A
A
E
N
L
A
E
T
--
A
S
K
V
G
G
T
A
--
L
W
L
D
V
T
A
D
D
A
V
D
K
I
S
E
H
L
R
D
H
H
G
G
K
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
-----------------
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
27
PsiBlast_CBE
93.94
100%
-101
- C2 -
3Q6I
2
?
B:
[12-446]
-------------------
S
F
L
A
R
Q
L
G
-
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
-
K
D
Y
D
L
V
G
--------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
P
D
A
K
P
A
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
D
S
T
P
P
A
D
W
E
K
-
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
--
E
-
S
A
A
E
N
L
A
E
T
--
A
S
K
V
G
G
T
A
--
L
W
L
D
V
T
A
D
D
A
V
D
K
I
S
E
H
L
R
D
H
H
G
G
K
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
Q
M
T
-
A
I
-------
P
L
A
T
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
24
PsiBlast_CBE
93.78
100%
-100
- C2 -
4FW8
2
?
B:
[20-454]
-------------------
S
F
L
A
R
Q
L
G
-
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
-
K
D
Y
D
L
V
G
--------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
P
D
A
K
P
A
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
D
S
T
P
P
A
D
W
E
K
-
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
--
E
-
S
A
A
E
N
L
A
E
T
--
A
S
K
V
G
G
T
A
--
L
W
L
D
V
T
A
D
D
A
V
D
K
I
S
E
H
L
R
D
H
H
G
G
K
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
Q
M
T
-
A
I
-------
P
L
A
T
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
26
PsiBlast_CBE
93.60
100%
-101
- C2 -
3Q6I
1
?
C:
[21-446]
----------------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
-
K
D
Y
D
L
V
G
N
N
---
R
W
A
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
P
D
A
K
P
A
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
D
S
T
P
P
A
D
W
E
K
-
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
--
E
-
S
A
A
E
N
L
A
E
T
--
A
S
K
V
G
G
T
A
--
L
W
L
D
V
T
A
D
D
A
V
D
K
I
S
E
H
L
R
D
H
H
G
G
K
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
-----
A
I
-------
P
L
A
T
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
25
PsiBlast_CBE
93.11
100%
-98
- C2 -
3Q6I
1
?
D:
[21-446]
----------------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
-
K
D
Y
D
L
V
G
--------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
P
D
A
K
P
A
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
D
S
T
P
P
A
D
W
E
K
-
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
--
E
-
S
---
N
L
A
E
T
--
A
S
K
V
G
G
T
A
--
L
W
L
D
V
T
A
D
D
A
V
D
K
I
S
E
H
L
R
D
H
H
G
G
K
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
-----
I
-------
P
L
A
T
R
E
-
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
4
PsiBlast_PDB
93.03
100%
-101
- C2 -
3V1U
3
?
A:
[37-462]
----------------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
-
K
D
Y
D
L
V
G
-------
A
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
P
D
A
K
P
A
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
D
S
T
P
P
A
D
W
E
K
-
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
--
E
-
S
A
A
E
N
L
A
E
T
--
A
S
K
V
G
G
T
A
--
L
W
L
D
V
T
A
D
D
A
V
D
K
I
S
E
H
L
R
D
H
H
G
G
K
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
Q
M
---
I
-------
P
L
A
T
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
23
PsiBlast_CBE
93.01
100%
-99
- C2 -
4FW8
1
?
C:
[29-454]
----------------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
-
K
D
Y
D
L
V
G
N
N
---
R
W
A
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
P
D
A
K
P
A
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
D
S
T
P
P
A
D
W
E
K
-
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
--
E
-
S
A
A
E
N
L
A
E
T
--
A
S
K
V
G
G
T
A
--
L
W
L
D
V
T
A
D
D
A
V
D
K
I
S
E
H
L
R
D
H
H
G
G
K
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
-----
A
I
-------
P
L
A
T
R
E
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
22
PsiBlast_CBE
92.71
100%
-101
- C2 -
4FW8
1
?
D:
[29-454]
----------------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
-
K
D
Y
D
L
V
G
--------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
P
D
A
K
P
A
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
D
S
T
P
P
A
D
W
E
K
-
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
--
E
-
S
---
N
L
A
E
T
--
A
S
K
V
G
G
T
A
--
L
W
L
D
V
T
A
D
D
A
V
D
K
I
S
E
H
L
R
D
H
H
G
G
K
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
-----
I
-------
P
L
A
T
R
E
-
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
1
PsiBlast_PDB
87.61
100%
-106
- C2 -
3LLS
8
?
A:
[50-475]
----------------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
-
K
D
Y
D
L
V
G
N
-------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
P
D
A
K
P
A
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
D
S
T
P
P
A
D
W
E
K
-
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
--
E
-
S
A
A
E
N
L
A
E
T
--
A
S
K
V
G
G
T
A
--
L
W
L
D
V
T
A
D
D
A
V
D
K
I
S
E
H
L
R
D
H
H
G
G
K
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
----------------------
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
21
PsiBlast_CBE
87.49
100%
-105
- C2 -
3LLS
7
?
B:
[52-475]
------------------------------
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
-
K
D
Y
D
L
V
G
-------
A
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
P
D
A
K
P
A
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
D
S
T
P
P
A
D
W
E
K
-
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
--
E
-
S
A
A
E
N
L
A
E
T
--
A
S
K
V
G
G
T
A
--
L
W
L
D
V
T
A
D
D
A
V
D
K
I
S
E
H
L
R
D
H
H
G
G
K
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
----------------------
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
104
Fugue
87.26
99%
-107
- C2 -
3LLS
8
?
A:
[50-475]
----------------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
-
K
D
Y
D
L
V
G
N
-------
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
P
D
A
K
P
A
A
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
G
A
D
D
S
T
P
P
A
D
W
E
K
-
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
A
I
D
V
--
E
-
S
A
A
E
N
L
A
E
T
--
A
S
K
V
G
G
T
A
--
L
W
L
D
V
T
A
D
D
A
V
D
K
I
S
E
H
L
R
D
H
H
G
G
K
A
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
R
R
L
N
----------------------
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
6
PsiBlast_PDB
87.07
83%
-96
- C2 -
3U0B
1
?
A:
[30-454]
-----------------------------
Q
P
E
T
L
R
R
Y
R
P
G
D
P
P
L
A
G
S
L
L
I
G
G
S
G
R
V
A
E
P
L
R
T
A
L
A
-
D
D
Y
N
L
V
S
N
N
I
G
G
R
W
A
D
S
F
G
G
V
V
F
D
A
T
G
I
T
E
A
E
G
L
K
E
L
Y
T
F
F
T
P
L
L
R
N
L
A
P
C
A
R
V
V
V
V
G
T
T
P
A
E
A
G
S
V
H
A
Q
V
V
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
V
S
L
V
Y
L
S
A
D
A
K
P
G
A
T
G
L
E
S
T
M
R
F
I
L
S
A
K
S
A
Y
V
D
G
Q
V
F
R
V
G
A
A
D
S
T
P
P
A
D
W
D
K
-
P
L
D
G
K
V
A
V
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
T
V
V
A
I
D
V
--
D
-
G
A
A
E
D
L
K
R
V
--
A
D
K
V
G
G
T
A
--
L
T
L
D
V
T
A
D
D
A
V
D
K
I
T
A
H
V
T
E
H
H
G
G
K
V
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
E
K
R
W
D
A
V
I
A
V
N
L
L
A
P
Q
R
L
T
E
G
L
V
G
N
G
T
I
G
E
G
G
R
V
I
G
L
S
S
M
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
L
A
E
A
L
A
P
V
L
A
D
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
-----------------
R
E
V
G
R
R
L
N
S
L
F
Q
G
G
Q
P
V
D
V
A
E
L
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
T
I
R
V
C
G
Q
A
M
L
G
A
114
HHSearch
84.51
82%
-93
- C2 -
3U0B
1
?
A:
[30-454]
-----------------------------
Q
P
E
T
L
R
R
Y
R
P
G
D
P
P
L
A
G
S
L
L
I
G
G
S
G
R
V
A
E
P
L
R
T
A
L
A
D
D
Y
N
L
V
S
N
N
I
G
-
G
R
W
A
D
S
F
G
G
V
V
F
D
A
T
G
I
T
E
A
E
G
L
K
E
L
Y
T
F
F
T
P
L
L
R
N
L
A
P
C
A
R
V
V
V
V
G
T
T
P
A
E
A
G
S
V
H
A
Q
V
V
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
V
S
L
V
Y
L
S
A
D
A
K
P
G
A
T
G
L
E
S
T
M
R
F
I
L
S
A
K
S
A
Y
V
D
G
Q
V
F
R
V
G
A
A
D
S
T
P
P
A
D
W
D
K
-
P
L
D
G
K
V
A
V
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
T
V
V
A
I
D
V
--
D
-
G
A
A
E
D
L
K
R
V
--
A
D
K
V
G
G
T
A
--
L
T
L
D
V
T
A
D
D
A
V
D
K
I
T
A
H
V
T
E
H
H
G
G
K
V
D
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
E
K
R
W
D
A
V
I
A
V
N
L
L
A
P
Q
R
L
T
E
G
L
V
G
N
G
T
I
G
E
G
G
R
V
I
G
L
S
S
M
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
L
A
E
A
L
A
P
V
L
A
D
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
-----------------
R
E
V
G
R
R
L
N
S
L
F
Q
G
G
Q
P
V
D
V
A
E
L
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
T
I
R
V
C
G
Q
A
M
L
G
A
76
PsiBlast_CBE
53.47
43%
-94
- C2 -
4BNV
1
FABG_PSEAE
B:
[23-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
--
S
A
S
G
A
E
K
I
A
E
T
L
K
A
N
G
V
E
G
A
G
--
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
G
-
Q
P
L
I
V
V
N
N
A
G
I
------------
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
G
R
I
I
N
I
G
S
V
V
G
-----
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
-------
P
E
A
Q
R
E
A
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
------
42
PsiBlast_CBE
53.33
43%
-97
- C2 -
4BO7
1
FABG_PSEAE
B:
[24-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
--
S
A
S
G
A
E
K
I
A
E
T
L
K
A
N
G
V
E
G
A
G
--
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
G
-
Q
P
L
I
V
V
N
N
A
G
I
------------
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
G
R
I
I
N
I
G
S
V
V
-----
A
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
-------
P
E
A
Q
R
E
A
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
------
71
PsiBlast_CBE
53.11
43%
-94
- C2 -
4BNX
1
FABG_PSEAE
C:
[16-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
L
Y
F
Q
S
M
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
--
S
A
S
G
A
E
K
I
A
E
T
L
K
A
N
G
V
E
G
A
G
--
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
G
-
Q
P
L
I
V
V
N
N
A
-----------
K
D
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
G
R
I
I
N
I
G
S
V
V
G
A
M
G
N
A
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
-------
P
E
A
Q
R
E
A
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
------
68
PsiBlast_CBE
52.93
43%
-91
- C2 -
4BNY
1
FABG_PSEAE
D:
[20-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
S
M
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
--
S
A
S
G
A
E
K
I
A
E
T
L
K
A
N
G
V
E
G
A
G
--
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
G
-
Q
P
L
I
V
V
N
N
A
G
I
------
V
R
M
K
D
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
G
R
I
I
N
I
G
S
V
V
G
A
M
G
N
A
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
-------
P
E
A
Q
R
E
A
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
------
56
PsiBlast_CBE
52.72
43%
-91
- C2 -
4BO2
1
FABG_PSEAE
D:
[18-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
F
Q
S
M
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
--
S
A
S
G
A
E
K
I
A
E
T
L
K
A
N
G
V
E
G
A
G
--
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
G
-
Q
P
L
I
V
V
N
N
A
G
I
-------
R
M
K
D
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
G
R
I
I
N
I
G
S
V
V
G
A
M
G
N
A
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
-------
P
E
A
Q
R
E
A
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
------
101
PsiBlast_CBE
49.38
40%
-83
- C2 -
2PNF
3
FABG_AQUAE
B:
[2-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-
K
L
Q
G
K
V
S
L
V
T
G
S
T
R
G
I
G
R
A
I
A
E
K
L
A
S
A
G
S
T
V
I
I
T
G
T
SG
E
-
R
A
K
A
V
A
E
E
I
--
A
N
K
Y
G
V
K
A
HG
V
E
M
N
L
L
S
E
E
S
I
N
K
A
F
E
E
I
Y
N
L
V
D
G
-
I
D
I
L
V
N
N
A
G
I
T
R
D
K
L
F
L
R
M
S
L
L
D
W
E
E
V
L
K
V
N
L
T
G
T
F
L
V
T
Q
N
S
L
R
K
M
I
K
Q
R
W
G
R
I
V
N
I
S
S
V
V
G
F
T
G
N
V
G
Q
V
N
Y
S
T
T
K
A
G
L
I
G
F
T
K
S
L
A
K
E
L
A
P
R
N
V
L
V
N
A
V
A
P
G
F
I
E
T
D
M
T
A
V
L
-------
S
E
E
I
K
Q
K
Y
K
E
Q
I
P
L
G
R
F
G
S
P
E
E
V
A
N
V
V
L
F
L
C
S
E
L
A
S
Y
I
T
G
E
V
I
H
V
N
G
------
90
PsiBlast_CBE
49.22
40%
-99
- C2 -
3TZC
5
?
A:
[10-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S-
E
-
S
G
A
Q
A
I
S
D
Y
--
L
G
D
-
N
G
K
G
--
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
-
V
D
I
L
V
N
N
A
G
I
T
R
----
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
------------
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
----DEQ
R
T
A
-
T
L
A
Q
V
P
A
G
R
L
-------
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
14
PsiBlast_PDB
48.86
43%
-79
- C2 -
4AG3
4
FABG_PSEAE
A:
[16-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
L
Y
F
Q
S
M
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
--
S
A
S
G
A
E
K
I
A
E
T
L
K
A
N
G
V
E
G
A
G
--
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
G
-
Q
P
L
I
V
V
N
N
A
G
I
T
R
D
N
L
L
V
R
M
K
D
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
G
R
I
I
N
I
G
S
V
V
G
A
M
G
N
A
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
-------
P
E
A
Q
R
E
A
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
------
102
PsiBlast_CBE
48.40
40%
-82
- C2 -
2PNF
3
FABG_AQUAE
A:
[2-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-
K
L
Q
G
K
V
S
L
V
T
G
S
T
R
G
I
G
R
A
I
A
E
K
L
A
S
A
G
S
T
V
I
I
T
G
T
S
G
E
-
R
A
K
A
V
A
E
E
I
--
A
N
K
Y
G
V
K
A
H
G
V
E
M
N
L
L
S
E
E
S
I
N
K
A
F
E
E
I
Y
N
L
V
D
G
-
I
D
I
L
V
N
N
A
G
I
T
R
D
K
L
F
L
R
M
S
L
L
D
W
E
E
V
L
K
V
N
L
T
G
T
F
L
V
T
Q
N
S
L
R
K
M
I
K
Q
R
W
G
R
I
V
N
I
S
S
V
V
G
F
T
G
N
V
G
Q
V
N
Y
S
T
T
K
A
G
L
I
G
F
T
K
S
L
A
K
E
L
A
P
R
N
V
L
V
N
A
V
A
P
G
F
I
E
T
D
M
T
A
V
L
-------
S
E
E
I
K
Q
K
Y
K
E
Q
I
P
L
G
R
F
G
S
P
E
E
V
A
N
V
V
L
F
L
C
S
E
L
A
S
Y
I
T
G
E
V
I
H
V
N
G
------
12
PsiBlast_PDB
47.70
40%
-88
- C2 -
4I08
6
FABG_VIBCH
A:
[10-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S-
E
-
S
G
A
Q
A
I
S
D
Y
--
L
G
D
-
N
G
K
G
--
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
-
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
----N
D
E
Q
R
T
A
T
L
A
Q
V
P
A
G
R
L
-------
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
11
PsiBlast_PDB
47.49
40%
-85
- C2 -
3RRO
11
FABG_VIBCH
A:
[10-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S-
E
-
S
G
A
Q
A
I
S
D
Y
--
L
G
D
-
N
G
K
G
--
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
-
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
T
A
T
L
A
Q
V
P
A
G
R
L
-------
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
35
PsiBlast_CBE
47.44
40%
-84
- C2 -
3RRO
13
FABG_VIBCH
B:
[10-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S-
E
-
S
G
A
Q
A
I
S
D
Y
--
L
G
D
-
N
G
K
G
--
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
-
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
NDEQRTA
T
L
A
Q
V
P
A
G
R
L
-------
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
30
PsiBlast_CBE
47.28
40%
-91
- C2 -
4WK6
1
?
B:
[10-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S-
E
-
S
G
A
Q
A
I
S
D
Y
--
L
G
D
-
N
G
K
G
--
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
-
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
A
S
V
V
G
T
M
----
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
T
A
T
L
A
Q
V
P
A
G
R
L
-------
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
9
PsiBlast_PDB
46.94
40%
-92
- C2 -
4WK6
1
?
A:
[10-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S-
E
-
S
G
A
Q
A
I
S
D
Y
--
L
G
D
-
N
G
K
G
--
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
-
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
A
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
T
A
T
L
A
Q
V
P
A
G
R
L
-------
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
28
PsiBlast_CBE
46.46
40%
-93
- C2 -
4WK6
2
?
D:
[10-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S-
E
-
S
G
A
Q
A
I
S
D
Y
--
L
G
D
-
N
G
K
G
--
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
-
V
D
I
L
V
N
N
A
G
I
T
---
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
A
S
---------
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
T
A
T
L
A
Q
V
P
A
G
R
L
-------
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
84
PsiBlast_CBE
46.44
43%
-77
- C2 -
4AG3
3
FABG_PSEAE
B:
[23-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
--
S
A
S
G
A
E
K
I
A
E
T
L
K
A
N
G
V
E
G
A
G
--
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
G
-
Q
P
L
I
V
V
N
N
A
G
I
T
R
D
N
L
L
V
R
M
K
D
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
G
R
I
I
N
I
G
S
V
V
G
A
M
G
N
A
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
-------
P
E
A
Q
R
E
A
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
------
10
PsiBlast_PDB
46.41
40%
-86
- C2 -
3RSH
11
FABG_VIBCH
A:
[10-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S-
E
-
S
G
A
Q
A
I
S
D
Y
--
L
G
D
-
N
G
K
G
--
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
-
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
--D
E
Q
R
T
A
-
T
L
A
Q
V
P
A
G
R
L
-------
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
103
PsiBlast_CBE
46.01
41%
-77
- C2 -
4NBU
2
?
D:
[11-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
F
--
N
-
E
A
A
G
K
E
A
V
E
--
A
N
P
-
G
V
V
F
--
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
-
K
I
D
I
L
I
N
N
A
G
I
T
R
D
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
G
K
G
K
I
I
N
T
S
S
V
T
G
T
Y
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
V
A
E
V
-------
P
E
K
V
I
E
K
M
K
A
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
M
--
33
PsiBlast_CBE
45.30
40%
-86
- C2 -
4I08
9
FABG_VIBCH
B:
[10-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S-
E
-
S
G
A
Q
A
I
S
D
Y
--
L
G
D
-
N
G
K
G
--
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
-
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
--
T
K
A
L
N
D
E
Q
R
T
A
T
L
A
Q
V
P
A
G
R
L
-------
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
34
PsiBlast_CBE
45.01
40%
-84
- C2 -
3RSH
12
FABG_VIBCH
B:
[10-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S-
E
-
S
G
A
Q
A
I
S
D
Y
--
L
G
D
-
N
G
K
G
--
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
-
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
-
L
N
D
E
Q
R
T
A
T
L
A
Q
V
P
A
G
R
L
-------
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
29
PsiBlast_CBE
43.93
40%
-88
- C2 -
4WK6
2
?
C:
[10-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S-
E
-
S
G
A
Q
A
I
S
D
Y
--
L
G
D
-
N
G
K
G
--
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
-
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
A
S
V
V
G
------
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
T
A
T
L
A
Q
V
P
A
G
R
L
-------
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------