@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0418: (2016-04-22 )
MVNKSRMMPAVLAVAVVVAFLTTGCIRWSTQSRPVVNGPAAAEFAVALRNRVSTDAMMAHLSKLQDIANANDGTRAVGTPGYQASVDYVVNTLRNSGFDVQTPEFSARVFKAEKGVVTLGGNTVEARALEYSLGTPPDGVTGPLVAAPADDSPGCSPSDYDRLPVSGAVVLVDRGVCPFAQKEDAAAQRGAVALIIADNIDEQAMGGTLGANTDVKIPVVSVTKSVGFQLRGQSGPTTVKLTASTQSFKARNVIAQTKTGSSANVVMAGAHLDSVPEGPGINDNGSGVAAVLETAVQLGNSPHVSNAVRFAFWGAEEFGLIGSRNYVESLDIDALKGIALYLNFDMLASPNPGYFTYDGDQSLPLDARGQPVVPEGSAGIERTFVAYLKMAGKTAQDTSFDGRSDYDGFTLAGIPSGGLFSGAEVKKSAEQAELWGGTADEPFDPNYHQKTDTLDHIDRTALGINGAGVAYAVGLYAQDLGGPNGVPVMADRTRHLIAKP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90....--...-.-100.......110-..---.-----.-...120-.---.-------------..---------------.--..--..130.......140.......150.......160-.------..--......170.....-------------..180.......190.......200-----------------------------.------------------.---------------------.--..--------.----.------------210------------------.--------------------....-....220.......230-------------------.-----..-.--------------------.-------------------------------....240-.-..-....250......----.260--.-........270.......280.......290.......300----.----....-----.-..310.......320.......330.......340.......350.---......360..---..------...370...-....380.......-390---..-------------------------.-----------..--..-.400.......410-........420.......430.......440.......450.......------460.......470.......480.......490.......500-------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVN
K
S
R
M
M
P
A
V
L
A
V
A
V
V
V
A
F
L
TTG
C
I
RWSTQSRPVVNG
P
A
A
A
E
F
A
V
A
L
R
NRV
S
T
D
A
M
M
A
H
L
S
K
L
Q
D
I
ANANDGTRAVGTPGYQ
A
S
V
D
Y
V
V
N
T
L
RN--SGF-D-VQTPEF
S
A
R
V
F
KA-EK---
G
-----
V
-
V
T
LG---G---N-------------
T
V
---------------
E
--
A
R
--
A
L
E
YSLGTPPDGVTGPLVAAPADDSPGCSPSDY---D------RL--PVS
G
A
V
V
L
V
DRGVC-------------PFAQKE
D
A
AAQRG
A
V
A
L
I
I
ADNI
D
E
-----------------------------
Q
------------------A---------------------M--GG--------T----L------------G--------------------A--------------------NT
D
V
-
K
I
P
V
V
S
V
TKSV
G
F
Q
L
---------------------R-----GQ-S--------------------G-------------------------------
P
T
T
V
K
L
T
-A-ST-QSFKAR
N
V
I
A
QTK----TG----S-SA
N
V
V
M
AGAHLDSVPEGPGINDNG
S
G
V
A
A
V
L
E
T
A
V
QLGN-S----P----HVSN-----
A
-
V
R
F
A
F
W
G
A
E
E
FGLIGSRN
Y
V
E
SL
D
I
D
A
LK
G
I
A
L
Y
L
N
F
D
MLASPNP
G
---
Y
F
T
YDGDQSLP---LD------ARGQPVVPE-GSA
G
I
E
R
T
F
V
A
Y
L
K
-MA----GK-------------------------T-----------AQ--DT-SFDGRSDYD
G
F
T
-
L
-AGIPSGGLFS
G
A
E
V
KK
S
A
E
Q
A
E
LWGGTADEPFDPNYHQKTD
T
L
D
H
I
D
R
------
T
ALGING
A
G
V
A
Y
A
V
G
L
Y
A
Q
DLGGPNGVPVMADRT
R
H
LIAKP---------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
95.58
30%
-64
- C1 -
2EK8
7
?
A:
[7-403]
---------------------------------------------
H
Q
I
T
K
R
T
D
A
E
N
M
Y
N
T
I
Q
F
L
S
Q
------
A
P
R
V
A
G
S
P
E
E
L
K
A
V
R
Y
I
E
Q
Q
F
K
S
--
Y
G
Y
-
H
-
V
E
V
Q
P
F
Q
F
E
G
Y
T
A
P
S
E
---
V
-----
T
-
L
K
I
G
---
T
---
E
-------------
K
K
---------------
E
--
G
E
--
A
F
T
Y
S
P
---
N
S
D
V
T
A
E
L
V
Y
V
----
G
L
G
-
T
T
A
D
V
---
A
------
G
K
--
D
L
N
G
K
I
A
L
I
Q
R
G
N
I
-------------
S
F
A
D
K
V
R
N
A
A
K
Q
G
A
K
A
V
I
I
Y
N
N
T
D
G
-----------------------------
K
----------------------------------------
L
--
N
G
--------
T
----
L
------------
G
--------------------
G
--------------------
S
D
A
S
-
F
V
A
A
V
G
I
T
K
Q
E
G
D
A
L
---------------------
A
-----
A
N
L
R
A
G------------------
E
K
I
-----------------------------
T
A
T
V
K
V
A
-
G
A
E
V
-
K
T
L
T
S
H
N
V
I
A
T
K
K
----
P
D
ANKK
N
-
T
N
D
I
I
I
I
G
S
H
H
D
S
V
E
K
A
P
G
A
N
D
D
A
S
G
V
A
V
T
L
E
L
A
R
V
M
S
K
-
L
---------
K
T
D
T
-----
E
-
L
R
F
I
T
F
G
A
E
E
N
G
L
I
G
S
K
K
Y
A
A
S
L
S
E
D
E
I
K
R
T
I
G
M
F
Q
L
D
M
V
G
S
K
D
A
G
---
D
L
I
M
Y
T
I
D
G
-----------------------
K
K
N
R
V
T
D
L
G
A
A
A
S
S
-
R
L
----
S
G
-------------------------------------
V
L
--
P
Y
-
G
Q
E
G
R
S
D
H
E
S
F
H
-
A
-
L
G
I
P
A
A
L
F
I
H
A
P
-------------------
V
E
P
W
Y
H
T
P
N
D
T
L
D
K
I
S
K
------
E
K
L
D
N
V
A
D
I
V
G
S
A
V
Y
Q
A
A
R
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
90.18
29%
-57
- C1 -
2EK8
5
?
A:
[30-385]
--------------------------------------------------------------------------
R
V
A
G
S
P
E
E
L
K
A
V
R
Y
I
E
Q
Q
F
K
S
--
Y
G
Y
-
H
-
V
E
V
Q
P
F
Q
F
E
G
Y
T
A
-
P
S
---
E
-----
V
T
L
K
I
G
---
T
---
E
-------------
K
K
---------------
E
--
G
E
--
A
F
T
Y
S
---
P
N
S
D
V
T
A
E
L
V
Y
V
G
L
G
T
T
A
D
V
A
G
K
D
----------------
L
N
G
K
I
A
L
I
Q
R
G
N
I
-------------
S
F
A
D
K
V
R
N
A
A
K
Q
G
A
K
A
V
I
I
Y
N
N
T
D
G
-----------------------------
K
----------------------------------------
L
--
N
G
--------
T
----
L
------------
G
--------------------
G
--------------------
S
D
A
S
-
F
V
A
A
V
G
I
T
K
Q
E
G
D
A
L
---------------------
A
A
N
L
R
A
G
E
-
K
--------------------
I
-------------------------------
T
A
T
V
K
V
A
G
A
-
E
V
-
K
T
L
T
S
H
N
V
I
A
T
K
K
PDAN
K
K
----
N
-
T
N
D
I
I
I
I
G
S
H
H
D
S
V
E
K
A
P
G
A
N
D
D
A
S
G
V
A
V
T
L
E
L
A
-
R
V
M
S
-
K
----
L
----
K
T
D
T
-----
E
-
L
R
F
I
T
F
G
A
E
E
N
G
L
I
G
S
K
K
Y
A
A
S
L
S
E
D
E
I
K
R
T
I
G
M
F
Q
L
D
M
V
G
S
K
D
A
G
D
L
I
M
Y
T
I
D
G
K
K
N
R
V
---
T
D
L
G
A
A
A
S
S
R
L
S
G
V
L
P
Y
-
G
Q
-------------------------------------------------------------------
E
G
R
S
D
H
E
S
F
H
-
A
-
L
G
I
P
A
-
A
L
F
I
H
A
------------------
P
V
E
P
W
Y
H
T
P
N
D
T
L
D
K
I
S
K
------
E
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
89.62
29%
-57
- C1 -
2EK9
6
?
A:
[30-385]
--------------------------------------------------------------------------
R
V
A
G
S
P
E
E
L
K
A
V
R
Y
I
E
Q
Q
F
K
S
--
Y
G
Y
-
H
-
V
E
V
Q
P
F
Q
F
E
G
Y
T
A
-
P
S
---
E
-----
V
T
L
K
I
G
---
T
---
E
-------------
K
K
---------------
E
--
G
E
--
A
F
T
Y
S
---
P
N
S
D
V
T
A
E
L
V
Y
V
G
L
G
T
T
A
D
V
A
G
K
D
----------------
L
N
G
K
I
A
L
I
Q
R
G
N
I
-------------
S
F
A
D
K
V
R
N
A
A
K
Q
G
A
K
A
V
I
I
Y
N
N
T
D
G
-----------------------------
K
----------------------------------------
L
--
N
G
--------
T
----
L
------------
G
--------------------
G
--------------------
S
D
A
S
-
F
V
A
A
V
G
I
T
K
Q
E
G
D
A
L
---------------------
A
A
N
L
R
A
G
E
-
K
--------------------
I
-------------------------------
T
A
T
V
K
V
A
G
A
-
E
V
-
K
T
L
T
S
H
N
V
I
A
T
K
K
PDAN
K
K
----
N
-
T
N
D
I
I
I
I
G
S
H
H
D
S
V
E
K
A
P
G
A
N
D
D
A
S
G
V
A
V
T
L
E
L
A
-
R
V
M
S
-
K
----
L
----
K
T
D
T
-----
E
-
L
R
F
I
T
F
G
A
E
E
N
G
L
I
G
S
K
K
Y
A
A
S
L
S
E
D
E
I
K
R
T
I
G
M
F
Q
L
D
M
V
G
S
K
D
A
G
D
L
I
M
Y
T
I
D
G
K
K
N
R
V
---
T
D
L
G
A
A
A
S
S
R
L
S
G
V
L
P
Y
-
G
Q
-------------------------------------------------------------------
E
G
R
S
D
H
E
S
F
H
-
A
-
L
G
I
P
A
-
A
L
F
I
H
A
------------------
P
V
E
P
W
Y
H
T
P
N
D
T
L
D
K
I
S
K
------
E
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
86.01
20%
-63
- C1 -
3KAS
7
TFR1_HUMAN
A:
[6-485]
------------------------------------------
D
L
K
R
K
L
S
E
K
L
D
S
T
D
F
T
S
T
I
K
L
L
N
E
N
S
-
Y
--
V
P
R
E
A
G
S
Q
K
D
E
N
L
A
L
Y
V
E
N
Q
F
R
E
--
F
K
L
-
S
K
V
W
R
D
Q
H
F
V
K
I
Q
V
K
-
D
S
A
Q
-
N
-----
S
-
V
I
I
V
D
KN
G
---
R
-------------
L
V
---------------
Y
--
L
V
EN
P
G
G
Y
V
A
Y
S
K
A
A
T
V
T
G
K
L
V
H
A
----
N
F
G
-
T
K
K
D
F
---
E
------
D
L
YT
P
V
N
G
S
I
V
I
V
R
A
G
K
I
-------------
T
F
A
E
K
V
A
N
A
E
S
L
N
A
I
G
V
L
I
Y
M
D
Q
T
K
-----------------------------
F
------------------
P
IVNAE
L
S
--------------
F
--
F
G
H
AHLGTGD
P
----
Y
TPGFPST
Q
F
P
P
S
R
--------------------
S
--------------------
S
G
L
P
-
N
I
P
V
Q
T
I
S
R
A
A
A
E
K
L
---------------------
F
-----
G
N
M
E
G
D
C
PSDWKTDSTCRMVTSES
K
-------------------------------
N
V
K
L
T
V
S
-
N
-
V
L
-
K
E
I
K
I
L
N
I
F
G
V
I
K
----
G
F
V---
E
-
P
D
H
Y
V
V
V
G
A
Q
R
D
A
W
G
--
P
G
A
A
K
S
G
V
G
T
A
L
L
L
K
L
A
Q
M
F
S
D
-
M
V
L
KD
G
F---
Q
P
S
R
-----
S
-
I
I
F
A
S
W
S
A
G
D
F
G
S
V
G
A
T
E
W
L
E
G
Y
L
S
S
L
H
L
K
A
F
T
Y
I
N
L
D
K
A
V
L
G
T
S
N
----
F
K
V
S
---------------------------
A
S
P
L
L
Y
T
L
I
E
K
T
M
Q
-
N
V
----
K
H
-------------------------
P
VTGQFLYQDSN
W
A
SK
V
E
-
K
L
T
L
D
N
A
A
F
P
F
L
A
Y
-
S
G
I
P
A
V
S
F
C
F
C
E
D
-----------------
T
D
Y
P
Y
L
G
T
T
M
D
T
Y
K
E
L
I
E
R
I
P
E
L
N
K
V
A
R
A
A
A
E
V
A
G
Q
F
V
I
K
L
T
H
D
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
85.60
21%
-54
- C1 -
4TWE
14
NALDL_HUMAN
A:
[42-586]
--------------------------------------
D
L
D
L
E
I
L
E
T
V
M
G
Q
L
D
A
H
R
I
R
E
N
L
R
E
L
S
R
------
E
P
H
L
A
S
S
P
R
D
E
D
L
V
Q
L
L
L
Q
R
W
K
D
PE
S
G
L
-
D
S
A
E
A
S
T
Y
E
V
L
L
S
F
P
-
S
Q
EQ
P
N
-----
V
-
V
D
I
V
---
G
PTG
G
I------------
I
H
SCHRTEENVTGEQGG
P
--
D
V
--
V
Q
P
Y
A
A
Y
A
P
S
G
T
P
Q
G
L
L
V
Y
A
----
N
R
G
-
A
E
E
D
F
---
K
E
L
Q
T
Q
-
G
I
--
K
L
E
G
T
I
A
L
T
R
Y
G
G
V
-------------
G
R
G
A
K
A
V
N
A
A
K
H
G
V
A
G
V
L
V
Y
T
D
P
A
D
-----------------------------
I
------------------
N
DGLSSPDETFPNSWYLPPS
G
V
E
--
R
G
--------
S
YYEY
F
------------
G
--------------------
D
PLTPYLPAVPSSFRVDLANV
S
G
F
P
-
P
I
P
T
Q
P
I
G
F
Q
D
A
R
D
L
---------------------
L
-----
C
N
L
N
--------------------
G
TLAPATWQGALG
C
H
Y
R
L
G
PGFRPDGDFPAD
S
Q
V
N
V
S
V
Y
-
N
-
R
L
-
E
L
R
N
S
S
N
V
L
G
I
I
R
----
G
A
V---
E
-
P
D
R
Y
V
L
Y
G
N
H
R
D
S
W
V
--
H
G
A
V
D
P
S
S
G
T
A
V
L
L
E
L
S
R
V
L
G
T
-
L
L
K
K
G
T
W---
R
P
R
R
-----
S
-
I
V
F
A
S
W
G
A
E
E
F
G
L
I
G
S
T
E
F
T
E
E
F
F
N
K
L
Q
E
R
T
V
A
Y
I
N
V
D
I
S
V
F
A
N
A
T
----
L
R
V
Q
G
T
P
P
V
Q
S
V
V
F
S
------
A
T
K
E
I
R
S
P
G
P
G
D
L
S
I
Y
D
N
W
I
R
Y
F
N
-
R
S
S
PVY
G
L
-------------------------
V
-----------
P
S
--
L
G
-
S
L
G
A
G
S
D
Y
A
P
F
V
-
H
F
L
G
I
S
S
M
D
I
A
Y
T
Y
D
R
S
-----------
K
T
S
A
R
I
Y
P
T
Y
H
T
A
F
D
T
F
D
Y
V
D
K
FLDPGF
S
S
H
Q
A
V
A
R
T
A
G
S
V
I
L
R
L
S
D
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
83.89
23%
-56
- C1 -
3IIB
5
?
A:
[12-436]
---------------------------------------------
Q
L
A
Q
K
A
Q
S
S
S
L
G
Y
D
I
V
E
S
L
T
V
--
E
V
--
G
P
R
L
A
G
S
E
Q
D
K
V
A
V
D
W
A
I
A
K
L
Q
S
--
L
G
F
-
D
R
V
Y
K
E
P
V
T
V
P
V
W
R
R
-
G
I
---
A
-----
K
-
A
S
I
L
---
S
P
F
P
Q
-------------
P
L
---------------
V
--
V
T
--
A
L
G
G
S
I
A
T
P
A
Q
G
L
S
A
T
I
V
R
F
----
D
T
---
L
Q
D
L
Q
N
A
E
------
A
G
--
S
L
N
D
K
I
A
F
I
D
A
K
T
E
R
H
RDG
K
G
Y
G
Q
T
AS
G
R
S
R
G
A
V
A
A
A
E
K
G
A
V
G
I
I
I
R
S
I
G
T
D
-----------------------------
H
D-----------------
R
---------------------
M
A
H
T
G
--------
M
----
M
------------
R
Y
-------------------
E
--------------------
E
G
V
T
-
A
I
P
A
A
A
I
S
N
P
D
A
D
L
I
---------------------
N
-----
A
M
L
K
R
D
K
E
----------------
V
-------------------------------
V
I
S
L
E
L
G
-
S
-
E
R
R
G
E
T
T
S
Y
N
V
I
A
E
V
K
----
G
S
----
T
K
A
D
E
I
V
L
I
G
A
H
L
D
S
W
D
E
G
T
G
A
I
D
D
G
A
G
V
A
I
V
T
A
A
A
K
H
I
L
D
-
L
----
P
Q---
K
P
E
R
-----
T
-
I
R
V
V
L
Y
A
A
E
E
L
G
L
L
G
G
K
T
Y
A
K
E
H
E
A
-
E
L
E
K
H
Y
I
A
A
E
S
D
F
G
A
G
P
I
Y
Q
----
I
D
W
R
V
A
D
---------------------
T
A
-
H
S
-
P
V
I
N
A
M
-
K
V
A
E
-
P
L
----
G
V
-------------------------
A
-----------
A
G
--
N
N
-
K
A
S
G
G
P
D
V
S
M
L
P
-
A
-
L
G
V
P
V
A
S
L
R
Q
D
G
S
-----------------
D
Y
F
D
Y
H
H
T
P
N
D
T
L
D
K
I
N
P
------
E
A
L
A
Q
N
V
A
V
Y
A
Q
F
A
W
V
M
A
N
S
K
V
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
82.16
19%
-61
- C1 -
3FED
8
NALD2_HUMAN
A:
[13-548]
------------------------------------------
S
I
R
W
K
L
V
S
E
M
K
A
E
N
I
K
S
F
L
R
S
F
T
K
------
L
P
H
L
A
G
T
E
Q
N
F
L
L
A
K
K
I
Q
T
Q
W
K
K
--
F
G
L
-
D
S
A
K
L
V
H
Y
D
V
L
L
S
Y
P
-
N
E
---
T
N
A
N
--
Y
-
I
S
I
V
---
D
EHE
T
EIFKTSPPPDGYE
N
V
---------------
T
--
N
I
--
V
P
P
Y
N
A
F
S
A
Q
G
M
P
E
G
D
L
V
Y
V
----
N
Y
A
-
R
T
E
D
F
---
F
K
L
E
REM
G
I
--
N
C
T
G
K
I
V
I
A
R
Y
G
K
I
-------------
F
R
G
N
K
V
K
N
A
M
L
A
G
A
I
G
I
I
L
Y
S
D
P
A
D
-----------------------------
Y
FAPEVQPYPKGWNLPGT
A
A
---------------------
Q
--
R
G
--------
N
----
V
LNLNGA------
G
DPLTPGYPAKEY
T
F
R
L
DVEE
G
--------------------
V
G
I
P
-
R
I
P
V
H
P
I
G
Y
N
D
A
E
I
L
---------------------
L
-----
R
Y
L
G
--------------------
G
I
APPDKSWKGALNVSY
S
I
G
PGFTGSSFR---
K
V
R
M
H
V
Y
-
N
-
I
N
-
K
I
T
R
I
Y
N
V
V
G
T
I
R
----
G
S
V---
E
-
P
D
R
Y
V
I
L
G
G
H
R
D
S
W
V
--
F
G
A
I
D
P
T
S
G
V
A
V
L
Q
E
I
A
R
S
F
G
K
-
L
----
M
S
K
G
W
R
P
R
R
-----
T
-
I
I
F
A
S
W
D
A
E
E
F
G
L
L
G
S
T
E
W
A
E
E
N
V
K
I
L
Q
E
R
S
I
A
Y
I
N
S
D
S
S
I
E
G
N
Y
T
----
L
R
V
D
C
---------------------------
T
P
L
L
Y
Q
L
V
Y
K
L
T
K
-
E
I
----
P
S
PDDGFESKS
L
Y
E
S
W
L
E
K
DPSPENKN
L
-----------
P
R
--
I
N
-
K
L
G
S
G
S
D
F
E
A
Y
F
-
Q
R
L
G
I
A
S
G
R
A
R
Y
T
K
N
K
K
T
-------
D
----
K
Y
S
S
Y
P
V
Y
H
T
I
Y
E
T
F
E
L
V
E
K
FYDPTF
K
K
Q
L
S
V
A
Q
L
R
G
A
L
V
Y
E
L
V
D
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------
75
Fugue
79.81
40%
-45
- C1 -
1F2P
4
APX_STRGG
A:
[1-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
D
I
P
L
A
N
V
K
A
H
L
T
Q
L
S
T
I
A
A
-----------------------------
N
------------------
N
---------------------
G
--
G
N
--------
R
----
A
------------
H
--------------------
G
--------------------
R
P
G
Y
-
K
A
S
V
D
Y
V
K
A
K
L
D
A
A
----------------------------------------------------
G
-------------------------------
Y
T
T
T
L
Q
Q
-
F
-
T
S
-
G
G
A
T
G
Y
N
L
I
A
N
W
P
----
G
G
----
D
-
P
N
K
V
L
M
A
G
A
H
L
D
S
V
S
S
G
A
G
I
N
D
N
G
S
G
S
A
A
V
L
E
T
A
L
A
V
S
R
A
G
----
Y
----
Q
P
D
K
-----
H
-
L
R
F
A
W
W
G
A
E
E
L
G
L
I
G
S
K
F
Y
V
N
N
L
P
S
A
D
R
S
K
L
A
G
Y
L
N
F
D
M
I
G
S
P
N
P
G
---
Y
--------------------------
F
V
Y
D
-
D
D
P
V
I
E
K
T
F
K
N
Y
F
A
-
G
L
----
N
V
-------------------------
P
-----------
T
----
E
-
I
E
T
E
R
S
D
H
A
P
F
K
-
N
-
V
G
V
P
V
G
G
L
F
T
G
A
G
Y
T
K
S
A
A
Q
A
Q
K
W
G
G
T
A
G
Q
A
F
D
R
C
Y
H
S
S
C
D
S
L
S
N
I
N
D
------
T
A
L
D
R
N
S
D
A
A
A
H
A
I
W
T
L
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
76.24
48%
-53
* C1 *
1TKJ
4
APX_STRGG
A:
[61-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
T
G
Y
N
L
I
A
N
W
P
----
G
G
----
D
-
P
N
K
V
L
M
A
G
A
H
L
D
S
V
S
S
G
A
G
I
N
D
N
G
S
G
S
A
A
V
L
E
T
A
L
A
V
S
R
-
A
----
G
Y---
Q
P
D
K
-----
H
-
L
R
F
A
W
W
G
A
E
E
L
G
L
I
G
S
K
F
Y
V
N
N
L
P
S
A
D
R
S
K
L
A
G
Y
L
N
F
D
M
I
G
S
P
N
P
G
---
Y
F
V
Y
D
---------------------------
D
D
P
V
I
E
K
T
F
K
N
Y
F
A
-
G
L
----
N
V
-------------------------
P
-----------
T
E
--
I
E
T
E
G
D
G
R
S
D
H
A
P
F
K
-
N
-
V
G
V
P
V
G
G
L
F
T
G
A
G
Y
T
K
S
A
A
Q
A
Q
K
W
G
G
T
A
G
Q
A
F
D
R
C
Y
H
S
S
C
D
S
L
S
N
I
N
D
------
T
A
L
D
R
N
S
D
A
A
A
H
A
I
W
T
L
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Fugue
76.04
18%
-49
- C1 -
1DE4
3
TFR1_HUMAN
C:
[2-636]
--------------------------------------
L
Y
W
D
D
L
K
R
K
L
S
E
K
L
D
S
T
D
F
T
S
T
I
K
L
L
N
E
---
N
S
Y
V
P
R
E
A
G
S
Q
K
D
E
N
L
A
L
Y
V
E
N
Q
F
R
E
--
F
K
L
S
K
-
V
W
R
D
Q
H
F
V
K
I
Q
V
K
-
D
S
---
A
Q
N
S
V
I
I
-
V
D
K
N
---
G
---
R
-------------
L
V
---------------
Y
L
V
E
N
--
P
G
G
Y
V
A
Y
S
K
A
A
T
V
T
G
K
L
V
H
A
N
F
G
-----
T
K
K
D
F
---
E
------
D
L
YT
P
V
N
G
S
I
V
I
V
R
A
G
K
I
-------------
T
F
A
E
K
V
A
N
A
E
S
L
N
A
I
G
V
L
I
Y
M
D
Q
T
K
FPIVNAE
L
S
F
F
G
H
AHLGTGDPYTPGFPSF
N
------------------
H
---------------------
T
--
Q
F
--------
P
----
P
------------
S
--------------------
R
--------------------
S
S
G
L
P
N
I
P
V
Q
T
I
S
R
A
A
A
E
K
L
F
G
N
MEGDCPSDWKTDSTCRMV
T
-----
S
E
-
S
--------------------
K
-------------------------------
N
V
K
L
T
V
S
-
N
-
V
L
-
K
E
I
K
I
L
N
I
F
G
V
I
K
G---
F
V
----
E
-
P
D
H
Y
V
V
V
G
A
Q
R
D
A
W
--
G
P
G
A
A
K
S
G
V
G
T
A
L
L
L
K
L
A
Q
M
F
S
D
-
M
----
V
----
L
K
D
G
FQPS
R
S
-
I
I
F
A
S
W
S
A
G
D
F
G
S
V
G
A
T
E
W
L
E
G
Y
L
S
S
L
H
L
K
A
F
T
Y
I
N
L
D
K
A
V
L
G
T
S
N
---
F
K
V
S
A
S
P
L
L
Y
T
---
L
I
------
E
K
T
M
Q
N
V
K
H
-
P
V
T
G
Q
F
-----
L
Y
Q
-
D
S
----
N
W
-------------------------
A
-----------
S
K
--
V
E
-
K
L
T
L
D
N
A
A
F
P
F
L
-
A
Y
S
G
I
P
A
V
S
F
C
F
C
-----------------
E
D
T
D
Y
P
Y
L
G
T
T
M
D
T
Y
K
E
L
I
E
R
I----
P
E
L
N
K
V
A
R
A
A
A
E
V
A
G
Q
F
V
I
K
L
T
H
D
V
E
L
N
L
D
Y
E
R
Y
N
S
Q
L
L
S
F
V
R
D
L
NQY
R
A
D
I
K
E
M
GLSL
Q
W
L
Y
S
A
R
G
D
F
F
R
A
T
S
R
L
T
T
D
F
G
N
AEKTD
R
F
V
M
K
K
L
N
D
R
V
M
R
V
EYHFLSPYVSPKESPFRHVFWGSGSHT
L
P
A
L
L
E
N
L
K
L
RKQNNGAFN
E
T
L
F
R
N
Q
L
A
L
A
T
W
T
I
Q
G
A
A
N
A
L
S
GDVWDI
8
PsiBlast_PDB
75.23
47%
-49
- C1 -
1TKH
4
APX_STRGG
A:
[66-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
I
A
N
W
P
----
G
G
----
D
-
P
N
K
V
L
M
A
G
A
H
L
D
S
V
S
S
G
A
G
I
N
D
N
G
S
G
S
A
A
V
L
E
T
A
L
A
V
S
R
-
A
----
G
----
Y
Q
P
D
-----
K
H
L
R
F
A
W
W
G
A
E
E
L
G
L
I
G
S
K
F
Y
V
N
N
L
P
S
A
D
R
S
K
L
A
G
Y
L
N
F
D
M
I
G
S
P
N
P
G
---
Y
F
V
Y
D
D
D
-------------------
P
V
--------
I
E
K
T
F
K
N
Y
F
A
G
L
N
----
V
P
-------------------------
T
-----------
E
I
--
E
T
-
E
---
R
S
D
H
A
P
F
K
-
N
-
V
G
V
P
V
G
G
L
F
T
G
A
G
Y
T
K
S
A
A
Q
A
Q
K
W
G
G
T
A
G
Q
A
F
D
R
C
Y
H
S
S
C
D
S
L
S
N
I
N
D
------
T
A
L
D
R
N
S
D
A
A
A
H
A
I
W
T
L
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.07
47%
-50
- C1 -
1F2O
4
APX_STRGG
A:
[66-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
I
A
N
W
P
----
G
G
----
D
-
P
N
K
V
L
M
A
G
A
H
L
D
S
V
S
S
G
A
G
I
N
D
N
G
S
G
S
A
A
V
L
E
T
A
L
A
V
S
R
-
A
----
G
----
Y
Q
P
D
-----
K
H
L
R
F
A
W
W
G
A
E
E
L
G
L
I
G
S
K
F
Y
V
N
N
L
P
S
A
D
R
S
K
L
A
G
Y
L
N
F
D
M
I
G
S
P
N
P
G
---
Y
F
V
Y
D
D
D
-------------------
P
V
--------
I
E
K
T
F
K
N
Y
F
A
G
L
N
----
V
P
-------------------------
T
-----------
E
I
--
E
T
-
E
G
D
G
R
S
D
H
A
P
F
K
-
N
-
V
G
V
P
V
G
G
L
F
T
G
A
G
Y
T
K
S
A
A
Q
A
Q
K
W
G
G
T
A
G
Q
A
F
D
R
C
Y
H
S
S
C
D
S
L
S
N
I
N
D
------
T
A
L
D
R
N
S
D
A
A
A
H
A
I
W
T
L
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.64
47%
-49
- C1 -
1TKF
4
APX_STRGG
A:
[66-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
I
A
N
W
P
----
G
G
----
D
-
P
N
K
V
L
M
A
G
A
H
L
D
S
V
S
S
G
A
G
I
N
D
N
G
S
G
S
A
A
V
L
E
T
A
L
A
V
S
R
-
A
----
G
----
Y
Q
P
D
-----
K
H
L
R
F
A
W
W
G
A
E
E
L
G
L
I
G
S
K
F
Y
V
N
N
L
P
S
A
D
R
S
K
L
A
G
Y
L
N
F
D
M
I
G
S
P
N
P
G
---
Y
F
V
Y
D
D
D
-------------------
P
V
--------
I
E
K
T
F
K
N
Y
F
A
G
L
N
----
V
P
-------------------------
T
-----------
E
I
--
E
-----
G
R
S
D
H
A
P
F
K
-
N
-
V
G
V
P
V
G
G
L
F
T
G
A
G
Y
T
K
S
A
A
Q
A
Q
K
W
G
G
T
A
G
Q
A
F
D
R
C
Y
H
S
S
C
D
S
L
S
N
I
N
D
------
T
A
L
D
R
N
S
D
A
A
A
H
A
I
W
T
L
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
74.62
47%
-51
- C1 -
1TKJ
4
APX_STRGG
A:
[66-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
I
A
N
W
P
----
G
G
----
D
-
P
N
K
V
L
M
A
G
A
H
L
D
S
V
S
S
G
A
G
I
N
D
N
G
S
G
S
A
A
V
L
E
T
A
L
A
V
S
R
-
A
----
G
----
Y
Q
P
D
-----
K
H
L
R
F
A
W
W
G
A
E
E
L
G
L
I
G
S
K
F
Y
V
N
N
L
P
S
A
D
R
S
K
L
A
G
Y
L
N
F
D
M
I
G
S
P
N
P
G
---
Y
F
V
Y
D
D
D
-------------------
P
V
--------
I
E
K
T
F
K
N
Y
F
A
G
L
N
----
V
P
-------------------------
T
-----------
E
I
--
E
T
-
E
G
D
G
R
S
D
H
A
P
F
K
-
N
-
V
G
V
P
V
G
G
L
F
T
G
A
G
Y
T
K
S
A
A
Q
A
Q
K
W
G
G
T
A
G
Q
A
F
D
R
C
Y
H
S
S
C
D
S
L
S
N
I
N
D
------
T
A
L
D
R
N
S
D
A
A
A
H
A
I
W
T
L
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.26
47%
-49
- C1 -
1QQ9
4
APX_STRGG
A:
[66-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
I
A
N
W
P
----
G
G
----
D
-
P
N
K
V
L
M
A
G
A
H
L
D
S
V
S
S
G
A
G
I
N
D
N
G
S
G
S
A
A
V
L
E
T
A
L
A
V
S
R
-
A
----
G
----
Y
Q
P
D
-----
K
H
L
R
F
A
W
W
G
A
E
E
L
G
L
I
G
S
K
F
Y
V
N
N
L
P
S
A
D
R
S
K
L
A
G
Y
L
N
F
D
M
I
G
S
P
N
P
G
---
Y
F
V
Y
D
D
D
-------------------
P
V
--------
I
E
K
T
F
K
N
Y
F
A
G
L
N
----
V
P
-------------------------
T
-----------
E
I
--
E
T
-
E
G
D
G
R
S
D
H
A
P
F
K
-
N
-
V
G
V
P
V
G
G
L
F
T
G
A
G
Y
T
K
S
A
A
Q
A
Q
K
W
G
G
T
A
G
Q
A
F
D
R
C
Y
H
S
S
C
D
S
L
S
N
I
N
D
------
T
A
L
D
R
N
S
D
A
A
A
H
A
I
W
T
L
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.19
47%
-50
- C1 -
1XBU
3
APX_STRGG
A:
[66-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
I
A
N
W
P
----
G
G
----
D
-
P
N
K
V
L
M
A
G
A
H
L
D
S
V
S
S
G
A
G
I
N
D
N
G
S
G
S
A
A
V
L
E
T
A
L
A
V
S
R
-
A
----
G
----
Y
Q
P
D
-----
K
H
L
R
F
A
W
W
G
A
E
E
L
G
L
I
G
S
K
F
Y
V
N
N
L
P
S
A
D
R
S
K
L
A
G
Y
L
N
F
D
M
I
G
S
P
N
P
G
---
Y
F
V
Y
D
D
D
-------------------
P
V
--------
I
E
K
T
F
K
N
Y
F
A
G
L
N
----
V
P
-------------------------
T
-----------
E
I
--
E
T
-
E
--
G
R
S
D
H
A
P
F
K
-
N
-
V
G
V
P
V
G
G
L
F
T
G
A
G
Y
T
K
S
A
A
Q
A
Q
K
W
G
G
T
A
G
Q
A
F
D
R
C
Y
H
S
S
C
D
S
L
S
N
I
N
D
------
T
A
L
D
R
N
S
D
A
A
A
H
A
I
W
T
L
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
74.13
47%
-48
- C1 -
1CP7
3
APX_STRGG
A:
[66-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
I
A
N
W
P
----
G
G
----
D
-
P
N
K
V
L
M
A
G
A
H
L
D
S
V
S
S
G
A
G
I
N
D
N
G
S
G
S
A
A
V
L
E
T
A
L
A
V
S
R
-
A
----
G
----
Y
Q
P
D
-----
K
H
L
R
F
A
W
W
G
A
E
E
L
G
L
I
G
S
K
F
Y
V
N
N
L
P
S
A
D
R
S
K
L
A
G
Y
L
N
F
D
M
I
G
S
P
N
P
G
---
Y
F
V
Y
D
D
D
-------------------
P
V
--------
I
E
K
T
F
K
N
Y
F
A
G
L
N
----
V
P
-------------------------
T
-----------
E
I
--
E
T
-
E
---
R
S
D
H
A
P
F
K
-
N
-
V
G
V
P
V
G
G
L
F
T
G
A
G
Y
T
K
S
A
A
Q
A
Q
K
W
G
G
T
A
G
Q
A
F
D
R
C
Y
H
S
S
C
D
S
L
S
N
I
N
D
------
T
A
L
D
R
N
S
D
A
A
A
H
A
I
W
T
L
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.01
47%
-53
- C1 -
1TF8
4
APX_STRGG
A:
[66-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
I
A
N
W
P
----
G
G
----
D
-
P
N
K
V
L
M
A
G
A
H
L
D
S
V
S
S
G
A
G
I
N
D
N
G
S
G
S
A
A
V
L
E
T
A
L
A
V
S
R
-
A
----
G
----
Y
Q
P
D
-----
K
H
L
R
F
A
W
W
G
A
E
E
L
G
L
I
G
S
K
F
Y
V
N
N
L
P
S
A
D
R
S
K
L
A
G
Y
L
N
F
D
M
I
G
S
P
N
P
G
---
Y
F
V
Y
D
D
D
-------------------
P
V
--------
I
E
K
T
F
K
N
Y
F
A
G
L
N
----
V
P
-------------------------
T
-----------
E
I
--
E
T
-----
R
S
D
H
A
P
F
K
-
N
-
V
G
V
P
V
G
G
L
F
T
G
A
G
Y
T
K
S
A
A
Q
A
Q
K
W
G
G
T
A
G
Q
A
F
D
R
C
Y
H
S
S
C
D
S
L
S
N
I
N
D
------
T
A
L
D
R
N
S
D
A
A
A
H
A
I
W
T
L
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.92
47%
-52
- C1 -
1F2P
4
APX_STRGG
A:
[66-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
I
A
N
W
P
----
G
G
----
D
-
P
N
K
V
L
M
A
G
A
H
L
D
S
V
S
S
G
A
G
I
N
D
N
G
S
G
S
A
A
V
L
E
T
A
L
A
V
S
R
-
A
----
G
----
Y
Q
P
D
-----
K
H
L
R
F
A
W
W
G
A
E
E
L
G
L
I
G
S
K
F
Y
V
N
N
L
P
S
A
D
R
S
K
L
A
G
Y
L
N
F
D
M
I
G
S
P
N
P
G
---
Y
F
V
Y
D
D
D
-------------------
P
V
--------
I
E
K
T
F
K
N
Y
F
A
G
L
N
----
V
P
-------------------------
T
-----------
E
I
--
E
T
-
E
---
R
S
D
H
A
P
F
K
-
N
-
V
G
V
P
V
G
G
L
F
T
G
A
G
Y
T
K
S
A
A
Q
A
Q
K
W
G
G
T
A
G
Q
A
F
D
R
C
Y
H
S
S
C
D
S
L
S
N
I
N
D
------
T
A
L
D
R
N
S
D
A
A
A
H
A
I
W
T
L
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.66
47%
-50
- C1 -
1TF9
4
APX_STRGG
A:
[66-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
I
A
N
W
P
----
G
G
----
D
-
P
N
K
V
L
M
A
G
A
H
L
D
S
V
S
S
G
A
G
I
N
D
N
G
S
G
S
A
A
V
L
E
T
A
L
A
V
S
R
-
A
----
G
----
Y
Q
P
D
-----
K
H
L
R
F
A
W
W
G
A
E
E
L
G
L
I
G
S
K
F
Y
V
N
N
L
P
S
A
D
R
S
K
L
A
G
Y
L
N
F
D
M
I
G
S
P
N
P
G
---
Y
F
V
Y
D
D
D
-------------------
P
V
--------
I
E
K
T
F
K
N
Y
F
A
G
L
N
----
V
P
-------------------------
T
-----------
E
I
--
E
T
-
E
--
G
R
S
D
H
A
P
F
K
-
N
-
V
G
V
P
V
G
G
L
F
T
G
A
G
Y
T
K
S
A
A
Q
A
Q
K
W
G
G
T
A
G
Q
A
F
D
R
C
Y
H
S
S
C
D
S
L
S
N
I
N
D
------
T
A
L
D
R
N
S
D
A
A
A
H
A
I
W
T
L
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------