@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1442: (2016-05-01 )
MQVYTSATHWGVFTARVHGGDIAAVAALASDTNPAPQLQNLPGAVRHRSRIANPAVRRGWLQHGPGPSSARGAEEFVEVSWDELIELLASELRRTVDRYGNEAIYGSSYGWASAGRFHHAQSQVHRFLNMLGGYTASRHSYSAGASEVIFPHIVGAALFEALAETTTWDVIVDHTALLVAFGGLPVKNTAVMPGGTTAHPDRDYVGRYRARGGRLVSVSPLRDDIAAIAGPLDDRCRWLAPVPGTDVAIMLGLAYVLATESLADRAFLGRYCTGYERFERYLLGLDDGIPKTPEWAAALSGLAAGDLRDLARRMAEHRTLITTSLSLQRIEHGEQTVWMAATLAAMLGQIGLPGGGFGHGYSSNGVGNPPLACGLPALPQGNNPVSTFIPVAAISELLQRPGQRLAYNGRLLELPDIKCVYWAGGNPFHHHQNLPRLRRALSRVDTIVVHEQYWTAMAKHADIVVPTTTSFERDDFAASKTNPTLIAMPAMVPPYANARDDYHTFSALAHRLGFGKQFTEGRSAREWLEHMYDKWSAELDFPVPSFAEFWRTGRLELPTRTGLTWLADFRADPAAHPLGTPSGRIEIFSDTVDAFALPDCAGHPTWYEPSEWLGGPRAARYPLHLIANQPRTRLHSQLDHGGASMASKIRGREPIRIHPDDAAARELTDGDIVRVFNDRGACLAGVVIDDGLRPKVVQLSTGAWFDPADPRDPDSMCVHGNPNALSNDSGTSSLAHGSTGQHVLVQIERFTGELPPVRAHEPPRLA
Atome Classification :
(20 SA)
--------.........10.---......-.20.......--------.-30--.......--..40........50........60.--------------------...----..-.-.-70........80........90........100.......110.......120.......130.--......140.......150.......160...-----.-..-.-170.......180.......190-.........200.--......-.210.----......220.....-..230.......240.......250.......260-----........270...-------------------------------------------------------------------------------------------------....280-----------------------------------------------------------------------------------------------------------------------------.-----------------------.......290.......300.......310..-.--.-----...320.......330.......340.......350.....---------..360------------....-..---.-.370--.----.-..-..-----..---------------380-------------..--------------..----------..-.--.390-------------..---------.---------....400........----------410-----------....--....420.......430....-...440-----------------------------.-........450.......460.......470...--.--.--.---.480.-.......490.......500.......510......-----------.--520--.----......-.------------------------------------------------.530-..---..----------------...----.--540---.--.---------------------------.----......550-.-------------.-------------..---..-.560.----....--...570........580.......590.......600.......610.-.--------.....620.......-630.......640-......-..650.......660.......670.......680......--.690.......700.......710.-------..-------......720--........730..----------------.....740--------------...-.-.....750.......760....---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------M
Q
V
Y
TSATH
W
G
V
---
F
T
A
R
VH-GG
D
I
A
A
V
A
A
L
--------A-S---DTNPAP
Q
--
L
QNL
P
G
A
V
R
H
R
S
RIA
N
P
A
V
R
R
G
W
L
Q--------------------HGP----GP-S-S-AR
G
A
E
E
F
V
EV
S
W
D
E
L
I
E
L
L
A
S
E
L
R
R
T
V
D
R
YGNE
A
I
YGSSYGWASAGRFH
H
A
Q
S
Q
V
H
R
F
L
N
M
LGG--YTASRHSYSAGASE
V
I
F
P
H
I
V
G
A
A
L
F
E
A
L
A
ET-----T-
T
W
-
D
-
V
I
VDH
T
A
L
L
V
A
FGGLPVKN
T
A
---VMPGGTTAHP-
D
R
--
D
Y
V
G
R
Y
-RARG
G
----
R
L
V
S
VS
P
L
R
D
D
I
A
A
-
I
AGP
L
D
DRC
R
W
LAPVPG
T
D
V
A
I
M
L
G
L
A
Y
V
L
A
T
E
S
------
L
A
D
R
A
F
L
G
R
YCT
G
Y
-------------------------------------------------------------------------------------------------
E
R
F
E
R
Y
------------------------------------------------------------------------------------------------------------------------------
L
-----------------------
L
GLDDGIPKT
P
E
W
A
A
A
L
S
GLAA
G
D
L
R
D
L
A
R
R
M
-
A
--E-----H
R
T
L
I
T
TS
L
S
L
Q
R
I
EHGE
Q
T
V
W
M
A
A
T
L
A
A
M
L
GQIGLPGGGF---------GHGY-------------SSNG-VG---N-PPL---A----C-GL-PA-----LP---------------QG--------------NN--------------
P
V
----------
S
T
-
F
--I
P
V
A
-------------
A
I
---------
S
---------
E
L
L
QRP-GQRLAYN
G
----------
R
-
L
-----------
L
ELP--D
I
K
C
V
Y
WAGGNP
F
H
HHQ
N
L
P
R
-
L
R
R
A
-------------------------------
L
-
S
RV
D
T
I
V
V
H
E
Q
Y
W
T
A
M
AKHA
D
I
V
V
PTTTSFERDD--F--A--A---SK-TN-
P
T
L
I
AMPAMVPPYANARDDY
H
T
F
S
A
L
A
H
RLGFGKQF-----------T--E----G----R
S
A
R
E
W
-
L
------------------------------------------------
E
H
M
--
Y
D
---
K
W----------------SAE----L--D-----F--P---------------------------V----
P
S
F
A
E
F
W
RT-G-------------R-------------LE---LP-TRT-G----
L
T
W
L
--
A
DFRA-DPAAHPLGTPSG
R
I
E
I
F
SDT
V
D
A
FALPDCAGHPTWY
E
P
S
E
WL-G--------GPRAARY
P
L
H
L
IANQ-
P
R
T
R
L
H
S
Q
LDHG--
G
A
S
M
A
S
-
K
IRGRE
P
I
R
IHPDD
A
A
A
RELTDG
D
I
V
R
V
FNDRG
A
C
L
A
G
V
V
I--DDGLR
P
K
V
V
Q
LSTGAWFDPADP--R-------DP-------D
S
M
C
VHGN---PNALSNDSGTSSL----------------AHGSTG----------------
Q
H
V
-
L
-
V
Q
I
E
R
F
TGELPPVRAHEPPRLA---
1
PsiBlast_PDB
99.33
40%
-80
- C3 -
1E18
6
DSTOR_RHOCA
A:
[52-822]
-------------
S
G
S
H
W
G
V
---
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
W
--------
E
-
K
---
D
P
H
P
S
P
M
--
L
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
E
--------------------
K
G
V
----
N
A
-
D
R
S
-
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
Q
G
V
F
G
G
S
Y
G
W
K
S
P
G
R
L
H
N
C
T
T
L
L
R
R
M
L
T
L
A
G
G
--
Y
V
N
G
A
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
--
L
E
V
Y
E
Q
Q
-----
T
-
A
W
-
P
-
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
IGW
V
I
P
E
-
H
G
A
Y
P
-
G
L
--
E
A
L
----
K
A
K
G
T
----
K
V
I
V
I
D
P
V
R
T
K
T
V
E
-
F
F
G
-----
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
------
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
-------------------------------------------------------------------------------------------------
D
K
F
L
P
Y
------------------------------------------------------------------------------------------------------------------------------
L
-----------------------
D
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
-
E
--
S
-----
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
---------
G
L
S
Y
-------------
H
Y
S
G
-
G
G
---
T
-
P
S
T
---
S
----
G
P
A
L
-
A
G
-----
I
T
---------------
D
G
--------------
G
A
--------------
A
T
KGPEWLAASG
A
S
-
V
--
I
P
V
A
-------------
R
V
---------
V
---------
D
M
L
E
N
P
-
G
A
E
F
D
F
N
G
----------
T
-
R
-----------
S
K
F
P
--
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
-
E
K
L
E
T
F
V
V
H
D
F
Q
W
T
P
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
--
I
--
E
T
I
G
---
D
Y
-
S
N
-
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
K
E
F
-----------
T
--
E
----
G
----
K
D
E
M
G
W
-
I
------------------------------------------------
K
S
F
--
Y
D
D
A
A
K
Q
----------------
G
K
A
----
A
--
G
-----
V
--
E
---------------------------
M
----
P
A
F
D
A
F
W
A
E
-
G
-------------
I
-------------
V
E
---
F
P
-
V
T
D
-
G
----
A
D
F
V
RY
A
S
F
R
E
-
D
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
-
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
L
N
G
T
--
V
L
R
E
G
Y
-
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
--
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
S
D
V
--
T
-------
E
P
-------
G
T
L
D
K
Y
G
D
---
V
N
V
L
S
A
D
I
G
T
S
K
L
----------------
A
Q
G
N
C
G
----------------
Q
T
V
-
L
-
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
---
9
PsiBlast_PDB
98.30
40%
-81
- C3 -
4DMR
5
DSTOR_RHOCA
A:
[52-822]
-------------
S
G
S
H
W
G
V
---
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
W
--------
E
-
K
---
D
P
H
P
S
P
M
--
L
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
E
--------------------
K
G
V
----
N
A
-
D
R
S
-
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
S
G
V
F
G
G
S
Y
G
W
K
S
P
G
R
L
H
N
C
T
T
L
L
R
R
M
L
T
L
A
G
G
--
Y
V
N
G
A
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
--
L
E
V
Y
E
Q
Q
-----
T
-
A
W
-
P
-
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
IGW
V
I
P
E
-
H
G
A
Y
P
-
G
L
--
E
A
L
----
K
A
K
G
T
----
K
V
I
V
I
D
P
V
R
T
K
T
V
E
-
F
F
G
-----
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
------
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
-------------------------------------------------------------------------------------------------
D
K
F
L
P
Y
------------------------------------------------------------------------------------------------------------------------------
L
-----------------------
D
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
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K
E
L
A
R
L
F
-
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--
S
-----
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
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H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
---------
G
L
S
Y
-------------
H
Y
S
G
-
G
G
---
T
-
P
S
T
---
S
----
G
P
A
L
-
A
G
-----
I
T
---------------
D
G
--------------
G
-----------------KGPEWLAAS----
V
--
I
P
V
A
-------------
R
V
---------
V
---------
D
M
L
E
N
P
-
G
A
E
F
D
F
N
G
----------
T
-
R
-----------
S
K
F
P
--
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
-
E
K
L
E
T
F
V
V
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F
Q
W
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N
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--
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--
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---
D
Y
-
S
N
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T
G
I
L
A
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K
I
V
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P
L
Y
E
A
R
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D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
E
F
-----------
T
--
E
----
G
----
K
D
E
M
G
W
-
I
------------------------------------------------
K
S
F
--
Y
D
D
A
A
K
Q
----------------
G
K
A
----
A
--
G
-----
V
--
Q
---------------------------
M
----
P
A
F
D
A
F
W
A
E
-
G
-------------
I
-------------
V
E
---
F
P
-
V
T
D
-
G
----
A
D
F
V
RY
A
S
F
R
E
-
D
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
-
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
L
N
G
T
--
V
L
R
E
G
Y
-
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
--
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
S
D
V
--
T
-------
E
P
-------
G
T
L
D
K
Y
G
D
---
V
N
V
L
S
A
D
I
G
T
S
K
L
----------------
A
Q
G
N
C
G
----------------
Q
T
V
-
L
-
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
---
3
PsiBlast_PDB
98.28
40%
-82
- C3 -
1E61
4
DSTOR_RHOCA
A:
[52-822]
-------------
S
G
S
H
W
G
V
---
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
W
--------
E
-
K
---
D
P
H
P
S
P
M
--
L
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
E
--------------------
K
G
V
----
N
A
-
D
R
S
-
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
F
G
G
S
Y
G
W
K
S
P
G
R
L
H
N
C
T
T
L
L
R
R
M
L
T
L
A
G
G
--
Y
V
N
G
A
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
--
L
E
V
Y
E
Q
Q
-----
T
-
A
W
-
P
-
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
IGW
V
I
P
E
-
H
G
A
Y
P
-
G
L
--
E
A
L
----
K
A
K
G
T
----
K
V
I
V
I
D
P
V
R
T
K
T
V
E
-
F
F
G
-----
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
------
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
-------------------------------------------------------------------------------------------------
D
K
F
L
P
Y
------------------------------------------------------------------------------------------------------------------------------
L
-----------------------
D
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
-
E
--
S
-----
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
---------
G
L
S
Y
-------------
H
Y
S
G
-
G
G
---
T
-
P
S
T
---
S
----
G
P
A
L
-
A
G
-----
I
T
---------------
D
G
--------------
G
-----------------G---------
A
S
-
V
--
I
P
V
A
-------------
R
V
---------
V
---------
D
M
L
E
N
P
-
G
A
E
F
D
F
N
G
----------
T
-
R
-----------
S
K
F
P
--
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
-
E
K
L
E
T
F
V
V
H
D
F
Q
W
T
P
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
--
I
--
E
T
I
G
---
D
Y
-
S
N
-
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
E
F
-----------
T
--
E
----
G
----
K
D
E
M
G
W
-
I
------------------------------------------------
K
S
F
--
Y
D
D
A
A
K
Q
----------------
G
K
A
----
A
--
G
-----
V
--
E
---------------------------
M
----
P
A
F
D
A
F
W
A
E
-
G
-------------
I
-------------
V
E
---
F
P
-
V
T
D
-
G
----
A
D
F
V
RY
A
S
F
R
E
-
D
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
-
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
L
N
G
T
--
V
L
R
E
G
Y
-
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
--
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
S
D
V
--
T
-------
E
P
-------
G
T
L
D
K
Y
G
D
---
V
N
V
L
S
A
D
I
G
T
S
K
L
----------------
A
Q
G
N
C
G
----------------
Q
T
V
-
L
-
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
---
21
PsiBlast_CBE
98.21
40%
-81
- C3 -
1E61
4
DSTOR_RHOCA
C:
[52-822]
-------------
S
G
S
H
W
G
V
---
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
W
--------
E
-
K
---
D
P
H
P
S
P
M
--
L
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
E
--------------------
K
G
V
----
N
A
-
D
R
S
-
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
F
G
G
S
Y
G
W
K
S
P
G
R
L
H
N
C
T
T
L
L
R
R
M
L
T
L
A
G
G
--
Y
V
N
G
A
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
--
L
E
V
Y
E
Q
Q
-----
T
-
A
W
-
P
-
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
IGW
V
I
P
E
-
H
G
A
Y
P
-
G
L
--
E
A
L
----
K
A
K
G
T
----
K
V
I
V
I
D
P
V
R
T
K
T
V
E
-
F
F
G
-----
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
------
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
-------------------------------------------------------------------------------------------------
D
K
F
L
P
Y
------------------------------------------------------------------------------------------------------------------------------
L
-----------------------
D
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
-
E
--
S
-----
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
---------
G
L
S
Y
-------------
H
Y
S
G
-
G
G
---
T
-
P
S
T
---
S
----
G
P
A
L
-
A
G
-----
I
T
---------------
D
G
--------------
G
-----------------G---------
A
S
-
V
--
I
P
V
A
-------------
R
V
---------
V
---------
D
M
L
E
N
P
-
G
A
E
F
D
F
N
G
----------
T
-
R
-----------
S
K
F
P
--
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
-
E
K
L
E
T
F
V
V
H
D
F
Q
W
T
P
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
--
I
--
E
TI
G
---
D
Y
-
S
N
-
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
E
F
-----------
T
--
E
----
G
----
K
D
E
M
G
W
-
I
------------------------------------------------
K
S
F
--
Y
D
DAA
K
Q
----------------
G
K
A
----
A
--
G
-----
V
--
E
---------------------------
M
----
P
A
F
D
A
F
W
A
E
-
G
-------------
I
-------------
V
E
---
F
P
-
V
T
D
-
G
----
A
D
F
V
RY
A
S
F
R
E
-
D
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
-
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
L
N
G
T
--
V
L
R
E
G
Y
-
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
--
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
S
D
V
--
T
-------
E
P
-------
G
T
L
D
K
Y
G
D
---
V
N
V
L
S
A
D
I
G
T
S
K
L
----------------
A
Q
G
N
C
G
----------------
Q
T
V
-
L
-
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
---
7
PsiBlast_PDB
98.18
40%
-81
- C3 -
2DMR
5
DSTOR_RHOCA
A:
[52-822]
-------------
S
G
S
H
W
G
V
---
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
W
--------
E
-
K
---
D
P
H
P
S
P
M
--
L
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
E
--------------------
K
G
V
----
N
A
-
D
R
S
-
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
F
G
G
S
Y
G
W
K
S
P
G
R
L
H
N
C
T
T
L
L
R
R
M
L
T
L
A
G
G
--
Y
V
N
G
A
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
--
L
E
V
Y
E
Q
Q
-----
T
-
A
W
-
P
-
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
IGW
V
I
P
E
-
H
G
A
Y
P
-
G
L
--
E
A
L
----
K
A
K
G
T
----
K
V
I
V
I
D
P
V
R
T
K
T
V
E
-
F
F
G
-----
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
------
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
-------------------------------------------------------------------------------------------------
D
K
F
L
P
Y
------------------------------------------------------------------------------------------------------------------------------
L
-----------------------
D
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
-
E
--
S
-----
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
---------
G
L
S
Y
-------------
H
Y
S
G
-
G
G
---
T
-
P
S
T
---
S
----
G
P
A
L
-
A
G
-----
I
T
---------------
D
G
--------------
G
A
--------------
A
T
KG--------
A
S
-
V
--
I
P
V
A
-------------
R
V
---------
V
---------
D
M
L
E
N
P
-
G
A
E
F
D
F
N
G
----------
T
-
R
-----------
S
K
F
P
--
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
-
E
K
L
E
T
F
V
V
H
D
F
Q
W
T
P
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
--
I
--
E
T
I
G
---
D
Y
-
S
N
-
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
E
F
-----------
T
--
E
----
G
----
K
D
E
M
G
W
-
I
------------------------------------------------
K
S
F
--
Y
D
D
A
A
K
Q
----------------
G
K
A
----
A
--
G
-----
V
--
Q
---------------------------
M
----
P
A
F
D
A
F
W
A
E
-
G
-------------
I
-------------
V
E
---
F
P
-
V
T
D
-
G
----
A
D
F
V
RY
A
S
F
R
E
-
D
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
-
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
L
N
G
T
--
V
L
R
E
G
Y
-
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
--
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
S
D
V
--
T
-------
E
P
-------
G
T
L
D
K
Y
G
D
---
V
N
V
L
S
A
D
I
G
T
S
K
L
----------------
A
Q
G
N
C
G
----------------
Q
T
V
-
L
-
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
---
24
PsiBlast_CBE
98.04
40%
-81
- C3 -
1E5V
4
DSTOR_RHOCA
C:
[52-822]
-------------
S
G
S
H
W
G
V
---
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
W
--------
E
-
K
---
D
P
H
P
S
P
M
--
L
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
E
--------------------
K
G
V
----
N
A
-
D
R
S
-
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
F
G
G
S
Y
G
W
K
S
P
G
R
L
H
N
C
T
T
L
L
R
R
M
L
T
L
A
G
G
--
Y
V
N
G
A
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
--
L
E
V
Y
E
Q
Q
-----
T
-
A
W
-
P
-
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
IGW
V
I
P
E
-
H
G
A
Y
P
-
G
L
--
E
A
L
----
K
A
K
G
T
----
K
V
I
V
I
D
P
V
R
T
K
T
V
E
-
F
F
G
-----
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
------
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
-------------------------------------------------------------------------------------------------
D
K
F
L
P
Y
------------------------------------------------------------------------------------------------------------------------------
L
-----------------------
D
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
-
E
--
S
-----
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
---------
G
L
S
Y
-------------
H
Y
S
G
-
G
G
---
T
-
P
S
T
---
S
----
G
P
A
L
-
A
G
-----
I
T
---------------
D
G
--------------------------------G---------
A
S
-
V
--
I
P
V
A
-------------
R
V
---------
V
---------
D
M
L
E
N
P
-
G
A
E
F
D
F
N
G
----------
T
-
R
-----------
S
K
F
P
--
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
-
E
K
L
E
T
F
V
V
H
D
F
Q
W
T
P
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
--
I
--
E
TI
G
---
D
Y
-
S
N
-
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
E
F
-----------
T
--
E
----
G
----
K
D
E
M
G
W
-
I
------------------------------------------------
K
S
F
--
Y
D
DAA
K
Q
----------------
G
K
A
----
A
--
G
-----
V
--
Q
---------------------------
M
----
P
A
F
D
A
F
W
A
E
-
G
-------------
I
-------------
V
E
---
F
P
-
V
T
D
-
G
----
A
D
F
V
RY
A
S
F
R
E
-
D
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
-
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
L
N
G
T
--
V
L
R
E
G
Y
-
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
--
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
S
D
V
--
T
-------
E
P
-------
G
T
L
D
K
Y
G
D
---
V
N
V
L
S
A
D
I
G
T
S
K
L
----------------
A
Q
G
N
C
G
----------------
Q
T
V
-
L
-
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
---
6
PsiBlast_PDB
98.02
40%
-80
- C3 -
1DMR
5
DSTOR_RHOCA
A:
[52-822]
-------------
S
G
S
H
W
G
V
---
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
W
--------
E
-
K
---
D
P
H
P
S
P
M
--
L
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
E
--------------------
K
G
V
----
N
A
-
D
R
S
-
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
F
G
G
S
Y
G
W
K
S
P
G
R
L
H
N
C
T
T
L
L
R
R
M
L
T
L
A
G
G
--
Y
V
N
G
A
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
--
L
E
V
Y
E
Q
Q
-----
T
-
A
W
-
P
-
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
IGW
V
I
P
E
-
H
G
A
Y
P
-
G
L
--
E
A
L
----
K
A
K
G
T
----
K
V
I
V
I
D
P
V
R
T
K
T
V
E
-
F
F
G
-----
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
------
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
-------------------------------------------------------------------------------------------------
D
K
F
L
P
Y
------------------------------------------------------------------------------------------------------------------------------
L
-----------------------
D
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
-
E
--
S
-----
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
---------
G
L
S
Y
-------------
H
Y
S
G
-
G
G
---
T
-
P
S
T
---
S
----
G
P
A
L
-
A
G
-----
I
T
---------------
D
G
--------------
G
A
--------------
A
T
KGPEWLAASG
A
S
-
V
--
I
P
V
A
-------------
R
V
---------
V
---------
D
M
L
E
N
P
-
G
A
E
F
D
F
N
G
----------
T
-
R
-----------
S
K
F
P
--
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
-
E
K
L
E
T
F
V
V
H
D
F
Q
W
T
P
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
--
I
--
E
T
I
G
---
D
Y
-
S
N
-
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
E
F
-----------
T
--
E
----
G
----
K
D
E
M
G
W
-
I
------------------------------------------------
K
S
F
--
Y
D
D
A
A
K
Q
----------------
G
K
A
----
A
--
G
-----
V
--
Q
---------------------------
M
----
P
A
F
D
A
F
W
A
E
-
G
-------------
I
-------------
V
E
---
F
P
-
V
T
D
-
G
----
A
D
F
V
RY
A
S
F
R
E
-
D
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
-
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
L
N
G
T
--
V
L
R
E
G
Y
-
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
--
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
S
D
V
--
T
-------
E
P
-------
G
T
L
D
K
Y
G
D
---
V
N
V
L
S
A
D
I
G
T
S
K
L
----------------
A
Q
G
N
C
G
----------------
Q
T
V
-
L
-
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
---
8
PsiBlast_PDB
97.90
40%
-79
- C3 -
3DMR
5
DSTOR_RHOCA
A:
[52-822]
-------------
S
G
S
H
W
G
V
---
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
W
--------
E
-
K
---
D
P
H
P
S
P
M
--
L
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
E
--------------------
K
G
V
----
N
A
-
D
R
S
-
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
F
G
G
S
Y
G
W
K
S
P
G
R
L
H
N
C
T
T
L
L
R
R
M
L
T
L
A
G
G
--
Y
V
N
G
A
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
--
L
E
V
Y
E
Q
Q
-----
T
-
A
W
-
P
-
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
IGW
V
I
P
E
-
H
G
A
Y
P
-
G
L
--
E
A
L
----
K
A
K
G
T
----
K
V
I
V
I
D
P
V
R
T
K
T
V
E
-
F
F
G
-----
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
------
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
-------------------------------------------------------------------------------------------------
D
K
F
L
P
Y
------------------------------------------------------------------------------------------------------------------------------
L
-----------------------
D
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
-
E
--
S
-----
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
---------
G
L
S
Y
-------------
H
Y
S
G
-
G
G
---
T
-
P
S
T
---
S
----
G
P
A
L
-
A
G
-----
I
T
---------------
D
G
--------------
G
A
--------------
A
T
KGPEWLAASG
A
S
-
V
--
I
P
V
A
-------------
R
V
---------
V
---------
D
M
L
E
N
P
-
G
A
E
F
D
F
N
G
----------
T
-
R
-----------
S
K
F
P
--
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
-
E
K
L
E
T
F
V
V
H
D
F
Q
W
T
P
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
--
I
--
E
T
I
G
---
D
Y
-
S
N
-
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
E
F
-----------
T
--
E
----
G
----
K
D
E
M
G
W
-
I
------------------------------------------------
K
S
F
--
Y
D
D
A
A
K
Q
----------------
G
K
A
----
A
--
G
-----
V
--
Q
---------------------------
M
----
P
A
F
D
A
F
W
A
E
-
G
-------------
I
-------------
V
E
---
F
P
-
V
T
D
-
G
----
A
D
F
V
RY
A
S
F
R
E
-
D
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
-
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
L
N
G
T
--
V
L
R
E
G
Y
-
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
--
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
S
D
V
--
T
-------
E
P
-------
G
T
L
D
K
Y
G
D
---
V
N
V
L
S
A
D
I
G
T
S
K
L
----------------
A
Q
G
N
C
G
----------------
Q
T
V
-
L
-
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
---
10
PsiBlast_PDB
97.82
39%
-82
- C3 -
1DMS
3
DSTOR_RHOCA
A:
[10-780]
-------------
S
G
S
H
W
G
V
---
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
W
--------
E
-
K
---
D
P
H
P
T
P
M
--
L
E
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
E
--------------------
K
G
V
----
N
A
-
D
R
S
-
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
Q
G
V
F
G
G
S
Y
G
W
K
S
P
G
R
L
H
N
C
T
T
L
L
R
R
M
L
T
L
A
G
G
--
Y
V
N
G
A
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
--
L
E
V
Y
E
Q
Q
-----
T
-
A
W
-
P
-
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
IGW
V
I
P
E
-
H
G
A
Y
P
-
G
L
--
E
A
L
----
K
A
K
G
T
----
K
V
I
V
I
D
P
V
R
T
K
T
V
E
-
F
F
G
-----
A
D
H
V
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
------
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
-------------------------------------------------------------------------------------------------
D
K
F
L
P
Y
------------------------------------------------------------------------------------------------------------------------------
L
-----------------------
M
G
E
T
D
S
T
P
K
T
A
E
W
A
S
D
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
-
K
--
S
-----
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
---------
G
L
S
Y
HYSGGGTPSSS
G
P
A
L
S
G
-
I
T
---
D
-
G
--------------------------------------------------------
G
--------------------------
A
S
-
V
--
I
P
V
A
-------------
R
V
---------
V
---------
D
M
L
E
N
P
-
G
A
E
F
D
F
N
G
----------
T
-
R
-----------
S
K
F
P
--
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
-
E
K
L
E
T
F
I
V
H
D
F
Q
W
T
P
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
--
I
--
E
T
I
G
---
D
Y
-
S
N
-
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
K
E
F
-----------
T
--
E
----
G
----
K
D
E
M
G
W
-
I
------------------------------------------------
K
S
F
--
Y
D
D
A
A
K
Q
----------------
G
K
A
----
G
--
G
-----
V
--
E
---------------------------
M
----
P
A
F
D
A
F
W
A
E
-
G
-------------
I
-------------
V
E
---
F
P
-
V
T
D
-
G
----
A
D
F
V
RY
A
S
F
R
E
-
D
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
-
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
L
N
G
T
--
V
L
R
E
G
Y
-
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
--
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
S
D
V
--
T
-------
E
A
-------
G
T
L
D
K
Y
G
D
---
V
N
V
L
S
A
D
I
G
T
S
K
L
----------------
A
Q
G
N
C
G
----------------
Q
T
V
-
L
-
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
---
22
PsiBlast_CBE
97.70
40%
-78
- C3 -
1E60
5
DSTOR_RHOCA
C:
[52-822]
-------------
S
G
S
H
W
G
V
---
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
W
--------
E
-
K
---
D
P
H
P
S
P
M
--
L
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
E
--------------------
K
G
V
----
N
A
-
D
R
S
-
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
F
G
G
S
Y
G
W
K
S
P
G
R
L
H
N
C
T
T
L
L
R
R
M
L
T
L
A
G
G
--
Y
V
N
G
A
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
--
L
E
V
Y
E
Q
Q
-----
T
-
A
W
-
P
-
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
IGW
V
I
P
E
-
H
G
A
Y
P
-
G
L
--
E
A
L
----
K
A
K
G
T
----
K
V
I
V
I
D
P
V
R
T
K
T
V
E
-
F
F
G
-----
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
------
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
-------------------------------------------------------------------------------------------------
D
K
F
L
P
Y
------------------------------------------------------------------------------------------------------------------------------
L
-----------------------
D
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
-
E
--
S
-----
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
---------
G
L
S
Y
-------------
H
Y
S
G
-
G
G
---
T
-
P
S
T
---
S
----
G
P
A
L
-
A
G
-----
I
T
---------------
D
G
--------------
G
-----------------AASG------
A
S
-
V
--
I
P
V
A
-------------
R
V
---------
V
---------
D
M
L
E
N
P
-
G
A
E
F
D
F
N
G
----------
T
-
R
-----------
S
K
F
P
--
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
-
E
K
L
E
T
F
V
V
H
D
F
Q
W
T
P
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
--
I
--
E
TI
G
---
D
Y
-
S
N
-
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
E
F
-----------
T
--
E
----
G
----
K
D
E
M
G
W
-
I
------------------------------------------------
K
S
F
--
Y
D
DAA
K
Q
----------------
G
K
A
----
A
--
G
-----
V
--
E
---------------------------
M
----
P
A
F
D
A
F
W
A
E
-
G
-------------
I
-------------
V
E
---
F
P
-
V
T
D
-
G
----
A
D
F
V
RY
A
S
F
R
E
-
D
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
-
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
L
N
G
T
--
V
L
R
E
G
Y
-
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
--
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
S
D
V
--
T
-------
E
P
-------
G
T
L
D
K
Y
G
D
---
V
N
V
L
S
A
D
I
G
T
S
K
L
----------------
A
Q
G
N
C
G
----------------
Q
T
V
-
L
-
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
---
2
PsiBlast_PDB
97.62
40%
-79
- C3 -
1E60
5
DSTOR_RHOCA
A:
[52-822]
-------------
S
G
S
H
W
G
V
---
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
W
--------
E
-
K
---
D
P
H
P
S
P
M
--
L
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
E
--------------------
K
G
V
----
N
A
-
D
R
S
-
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
F
G
G
S
Y
G
W
K
S
P
G
R
L
H
N
C
T
T
L
L
R
R
M
L
T
L
A
G
G
--
Y
V
N
G
A
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
--
L
E
V
Y
E
Q
Q
-----
T
-
A
W
-
P
-
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
IGW
V
I
P
E
-
H
G
A
Y
P
-
G
L
--
E
A
L
----
K
A
K
G
T
----
K
V
I
V
I
D
P
V
R
T
K
T
V
E
-
F
F
G
-----
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
------
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
-------------------------------------------------------------------------------------------------
D
K
F
L
P
Y
------------------------------------------------------------------------------------------------------------------------------
L
-----------------------
D
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
-
E
--
S
-----
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
---------
G
L
S
Y
-------------
H
Y
S
G
-
G
G
---
T
-
P
S
T
---
S
----
G
P
A
L
-
A
G
-----
I
T
---------------
D
G
--------------
G
A
--------------
A
T
KGPEWLAASG
A
S
-
V
--
I
P
V
A
-------------
R
V
---------
V
---------
D
M
L
E
N
P
-
G
A
E
F
D
F
N
G
----------
T
-
R
-----------
S
K
F
P
--
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
-
E
K
L
E
T
F
V
V
H
D
F
Q
W
T
P
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
--
I
--
E
T
I
G
---
D
Y
-
S
N
-
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
E
F
-----------
T
--
E
----
G
----
K
D
E
M
G
W
-
I
------------------------------------------------
K
S
F
--
Y
D
D
A
A
K
Q
----------------
G
K
A
----
A
--
G
-----
V
--
E
---------------------------
M
----
P
A
F
D
A
F
W
A
E
-
G
-------------
I
-------------
V
E
---
F
P
-
V
T
D
-
G
----
A
D
F
V
RY
A
S
F
R
E
-
D
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
-
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
L
N
G
T
--
V
L
R
E
G
Y
-
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
--
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
S
D
V
--
T
-------
E
P
-------
G
T
L
D
K
Y
G
D
---
V
N
V
L
S
A
D
I
G
T
S
K
L
----------------
A
Q
G
N
C
G
----------------
Q
T
V
-
L
-
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
---
4
PsiBlast_PDB
97.57
40%
-83
- C3 -
1E5V
4
DSTOR_RHOCA
A:
[52-822]
-------------
S
G
S
H
W
G
V
---
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
W
--------
E
-
K
---
D
P
H
P
S
P
M
--
L
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
E
--------------------
K
G
V
----
N
A
-
D
R
S
-
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
F
G
G
S
Y
G
W
K
S
P
G
R
L
H
N
C
T
T
L
L
R
R
M
L
T
L
A
G
G
--
Y
V
N
G
A
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
--
L
E
V
Y
E
Q
Q
-----
T
-
A
W
-
P
-
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
IGW
V
I
P
E
-
H
G
A
Y
P
-
G
L
--
E
A
L
----
K
A
K
G
T
----
K
V
I
V
I
D
P
V
R
T
K
T
V
E
-
F
F
G
-----
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
------
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
-------------------------------------------------------------------------------------------------
D
K
F
L
P
Y
------------------------------------------------------------------------------------------------------------------------------
L
-----------------------
D
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
-
E
--
S
-----
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
---------
G
L
S
Y
-------------
H
Y
S
G
-
G
G
---
T
-
P
S
T
---
S
----
G
P
A
L
-
A
G
-----
I
T
---------------
D
G
--------------------------------G---------
A
S
-
V
--
I
P
V
A
-------------
R
V
---------
V
---------
D
M
L
E
N
P
-
G
A
E
F
D
F
N
G
----------
T
-
R
-----------
S
K
F
P
--
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
-
E
K
L
E
T
F
V
V
H
D
F
Q
W
T
P
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
--
I
--
E
T
I
G
---
D
Y
-
S
N
-
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
E
F
-----------
T
--
E
----
G
----
K
D
E
M
G
W
-
I
------------------------------------------------
K
S
F
--
Y
D
D
A
A
K
Q
----------------
G
K
A
----
A
--
G
-----
V
--
Q
---------------------------
M
----
P
A
F
D
A
F
W
A
E
-
G
-------------
I
-------------
V
E
---
F
P
-
V
T
D
-
G
----
A
D
F
V
RY
A
S
F
R
E
-
D
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
-
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
L
N
G
T
--
V
L
R
E
G
Y
-
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
--
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
S
D
V
--
T
-------
E
P
-------
G
T
L
D
K
Y
G
D
---
V
N
V
L
S
A
D
I
G
T
S
K
L
----------------
A
Q
G
N
C
G
----------------
Q
T
V
-
L
-
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
---
23
PsiBlast_CBE
97.38
40%
-78
- C3 -
1H5N
4
DSTOR_RHOCA
C:
[52-822]
-------------
S
G
S
H
W
G
V
---
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
W
--------
E
-
K
---
D
P
H
P
S
P
M
--
L
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
E
--------------------
K
G
V
----
N
A
-
D
R
S
-
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
F
G
G
S
Y
G
W
K
S
P
G
R
L
H
N
C
T
T
L
L
R
R
M
L
T
L
A
G
G
--
Y
V
N
G
A
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
--
L
E
V
Y
E
Q
Q
-----
T
-
A
W
-
P
-
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
IGW
V
I
P
E
-
H
G
A
Y
P
-
G
L
--
E
A
L
----
K
A
K
G
T
----
K
V
I
V
I
D
P
V
R
T
K
T
V
E
-
F
F
G
-----
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
------
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
-------------------------------------------------------------------------------------------------
D
K
F
L
P
Y
------------------------------------------------------------------------------------------------------------------------------
L
-----------------------
D
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
-
E
--
S
-----
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
---------
G
L
S
Y
-------------
H
Y
S
G
-
G
G
---
T
-
P
S
T
---
S
----
G
P
A
L
-
A
G
-----
I
T
---------------
D
G
--------------------------------G---------
A
S
-
V
--
I
P
V
A
-------------
R
V
---------
V
---------
D
M
L
E
N
P
-
G
A
E
F
D
F
N
G
----------
T
-
R
-----------
S
K
F
P
--
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
-
E
K
L
E
T
F
V
V
H
D
F
Q
W
T
P
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
--
I
--
E
TI
G
---
D
Y
-
S
N
-
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
E
F
-----------
T
--
E
----
G
----
K
D
E
M
G
W
-
I
------------------------------------------------
K
S
F
--
Y
D
DAA
K
Q
----------------
G
K
A
----
A
--
G
-----
V
--
Q
---------------------------
M
----
P
A
F
D
A
F
W
A
E
-
G
-------------
I
-------------
V
E
---
F
P
-
V
T
D
-
G
----
A
D
F
V
RY
A
S
F
R
E
-
D
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
-
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
L
N
G
T
--
V
L
R
E
G
Y
-
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
--
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
S
D
V
--
T
-------
E
P
-------
G
T
L
D
K
Y
G
D
---
V
N
V
L
S
A
D
I
G
T
S
K
L
----------------
A
Q
G
N
C
G
----------------
Q
T
V
-
L
-
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
---
5
PsiBlast_PDB
97.35
40%
-79
- C3 -
1H5N
4
DSTOR_RHOCA
A:
[52-822]
-------------
S
G
S
H
W
G
V
---
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
W
--------
E
-
K
---
D
P
H
P
S
P
M
--
L
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
E
--------------------
K
G
V
----
N
A
-
D
R
S
-
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
V
E
E
T
Y
G
P
E
G
V
F
G
G
S
Y
G
W
K
S
P
G
R
L
H
N
C
T
T
L
L
R
R
M
L
T
L
A
G
G
--
Y
V
N
G
A
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
--
L
E
V
Y
E
Q
Q
-----
T
-
A
W
-
P
-
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
IGW
V
I
P
E
-
H
G
A
Y
P
-
G
L
--
E
A
L
----
K
A
K
G
T
----
K
V
I
V
I
D
P
V
R
T
K
T
V
E
-
F
F
G
-----
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
D
------
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
-------------------------------------------------------------------------------------------------
D
K
F
L
P
Y
------------------------------------------------------------------------------------------------------------------------------
L
-----------------------
D
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
-
E
--
S
-----
K
R
T
M
L
A
A
G
W
S
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
---------
G
L
S
Y
-------------
H
Y
S
G
-
G
G
---
T
-
P
S
T
---
S
----
G
P
A
L
-
A
G
-----
I
T
---------------
D
G
--------------------------------G---------
A
S
-
V
--
I
P
V
A
-------------
R
V
---------
V
---------
D
M
L
E
N
P
-
G
A
E
F
D
F
N
G
----------
T
-
R
-----------
S
K
F
P
--
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
-
E
K
L
E
T
F
V
V
H
D
F
Q
W
T
P
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
--
I
--
E
T
I
G
---
D
Y
-
S
N
-
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
A
E
F
-----------
T
--
E
----
G
----
K
D
E
M
G
W
-
I
------------------------------------------------
K
S
F
--
Y
D
D
A
A
K
Q
----------------
G
K
A
----
A
--
G
-----
V
--
Q
---------------------------
M
----
P
A
F
D
A
F
W
A
E
-
G
-------------
I
-------------
V
E
---
F
P
-
V
T
D
-
G
----
A
D
F
V
RY
A
S
F
R
E
-
D
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
-
G
A
K
Y
P
L
H
I
A
A
S
H
-
P
F
N
R
L
H
S
Q
L
N
G
T
--
V
L
R
E
G
Y
-
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
L
T
G
V
K
V
--
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
S
D
V
--
T
-------
E
P
-------
G
T
L
D
K
Y
G
D
---
V
N
V
L
S
A
D
I
G
T
S
K
L
----------------
A
Q
G
N
C
G
----------------
Q
T
V
-
L
-
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
---
11
PsiBlast_PDB
95.39
35%
-79
- C3 -
1TMO
3
TORA_SHEMA
A:
[42-824]
------------
T
T
G
S
H
F
G
A
---
F
K
M
K
R
K
-
N
G
V
I
A
E
V
K
P
F
--------
D
-
L
---
D
K
Y
P
T
D
M
--
I
N
G
I
R
G
M
V
Y
N
P
S
R
V
R
Y
P
M
V
R
L
D
F
L
L
--------------------
K
G
H
----
K
S
-
N
-
T
H
Q
R
G
D
F
R
F
V
R
V
T
W
D
K
A
L
T
L
F
K
H
S
L
D
E
V
Q
T
Q
Y
G
P
S
G
L
H
A
G
Q
T
G
W
R
A
T
G
Q
L
H
S
S
T
S
H
M
Q
R
A
V
G
M
H
G
N
--
Y
V
K
K
I
G
D
Y
S
T
G
A
G
Q
T
I
L
P
Y
V
L
G
S
T
--
E
V
Y
A
Q
G
-----
T
-
S
W
-
P
-
L
I
L
E
H
S
D
T
I
V
L
W
S
N
D
P
Y
K
N
L
Q
---
V
G
W
N
A
E
T
-
H
E
-
S
F
--
A
Y
L
A
Q
L
-
K
E
K
V
K
Q
GK
I
R
V
I
S
I
D
P
V
V
T
K
T
Q
A
-
Y
L
G
-----
C
E
Q
L
Y
V
N
P
Q
T
D
V
T
L
M
L
A
I
A
H
E
M
I
S
K
K
------
L
Y
D
D
K
F
I
Q
G
Y
S
L
G
F
-------------------------------------------------------------------------------------------------
E
E
F
V
P
Y
------------------------------------------------------------------------------------------------------------------------------
V
-----------------------
M
G
T
K
D
G
V
A
K
T
P
E
W
A
A
P
I
C
G
V
E
A
H
V
I
R
D
L
A
K
T
L
-
V
--
K
-----
G
R
T
Q
F
M
M
G
W
C
I
Q
R
Q
Q
H
G
E
Q
P
Y
W
M
A
A
V
L
A
T
M
I
G
Q
I
G
L
P
G
G
G
I
---------
S
Y
G
H
-------------
H
Y
S
S
-
I
G
---
V
-
P
S
S
---
G
----
A
-
A
A
-
P
G
A
F
P
RN
L
D
---------------
E
N
--------------
Q
K
--------------
P
L
FDSSDFKGA-
S
S
-
T
--
I
P
V
A
-------------
R
W
---------
I
---------
D
A
I
L
E
P
-
G
K
T
I
D
A
N
G
----------
S
-
K
-----------
V
V
Y
P
--
D
I
K
M
M
I
F
S
G
N
N
P
W
N
H
H
Q
D
R
N
R
-
M
K
Q
A
-------------------------------
F
-
H
K
L
E
C
V
V
T
V
D
V
N
W
T
A
T
C
R
F
S
D
I
V
L
P
A
C
T
T
Y
E
R
N
D
--
I
D
V
Y
--
G
---
A
Y
-
A
N
-
R
G
I
L
A
M
Q
K
M
V
E
P
L
F
D
S
L
S
D
F
E
I
F
T
R
F
A
A
V
L
G
K
E
K
E
Y
-----------
T
--
R
----
N
----
M
G
E
M
E
W
-
L
------------------------------------------------
E
T
L
--
Y
N
---
E
C
----------------
K
A
A
----
N
AG
K
-----
F
--
E
---------------------------
M
----
P
D
F
A
T
F
W
K
Q
-
G
-------------
Y
-------------
V
H
---
F
G
-
D
G
E
-
V
----
W
T
R
H
--
A
D
F
R
N
-
D
P
E
I
N
P
L
G
T
P
S
G
L
I
E
I
F
S
R
K
I
D
Q
F
G
Y
D
D
C
K
G
H
P
T
W
M
E
K
T
E
R
S
H
G
--------
G
P
G
S
D
K
H
P
I
W
L
Q
S
C
H
-
P
D
K
R
L
H
S
Q
M
C
E
S
--
R
E
Y
R
E
T
Y
A
V
N
G
R
E
P
V
Y
I
S
P
V
D
A
K
A
R
G
I
K
D
G
D
I
V
R
V
F
N
D
R
G
Q
L
L
A
G
A
V
V
--
S
D
N
F
P
K
G
I
V
R
I
H
E
G
A
W
Y
G
P
V
G
K
--
D
GSTEGGA
E
V
-------
G
A
L
C
S
Y
G
D
---
P
N
T
L
T
L
D
I
G
T
S
K
L
----------------
A
Q
A
C
S
A
----------------
Y
T
C
-
L
-
V
E
F
E
K
Y
Q
G
K
V
P
K
V
S
S
F
D
G
P
------
34
HHSearch
86.92
33%
-71
- C3 -
1TMO
3
TORA_SHEMA
A:
[40-824]
----------
W
L
T
T
G
S
H
F
G
A
---
F
K
M
K
R
K
-
N
G
V
I
A
E
V
K
P
F
--------
D
-
L
---
D
K
Y
P
T
D
M
--
I
N
G
I
R
G
M
V
Y
N
P
S
R
V
R
Y
P
M
V
R
L
D
F
L
L
--------------------
K
G
H
----
K
S
N
T
-
H
-
Q
R
G
D
F
R
F
V
R
V
T
W
D
K
A
L
T
L
F
K
H
S
L
D
E
V
Q
T
Q
Y
G
P
S
G
L
H
A
G
Q
T
G
W
R
-
A
T
G
-
Q
L
H
S
S
T
-
S
H
M
Q
R
A
V
G
M
H
G
N
Y
V
K
-----
K
I
G
D
Y
S
T
G
A
G
Q
T
I
L
P
--
Y
V
L
G
S
T
EVYAQ
G
-
T
S
W
P
-
L
I
L
E
H
S
D
T
I
V
L
W
S
N
D
P
Y
K
N
L
Q
---
V
G
W
N
A
E
T
H
E
S
-
F
A
Y
L
A
Q
L
K
E
K
V
K
Q
G
K
I
----
R
V
I
S
I
D
P
V
V
T
K
T
Q
A
Y
L
G
------
C
E
Q
L
Y
V
N
P
Q
T
D
V
T
L
M
L
A
I
A
H
E
M
I
S
K
K
------
L
Y
D
D
K
F
I
Q
G
Y
S
L
G
F
-------------------------------------------------------------------------------------------------
E
E
F
V
P
Y
------------------------------------------------------------------------------------------------------------------------------
V
-----------------------
M
G
T
K
D
G
V
A
K
T
P
E
W
A
A
P
I
C
G
V
E
A
H
V
I
R
D
L
A
K
T
L
V
K
--
G
------
R
T
Q
F
M
M
G
W
C
I
Q
R
Q
Q
H
G
E
Q
P
Y
W
M
A
A
V
L
A
T
M
I
G
Q
I
G
L
P
G
G
G
I
---------
S
Y
G
H
-------------
H
-
Y
S
-
S
I
---
G
V
P
S
S
---
G
A
A
A
P
G
-
A
F
-
P
R
-----
N
L
DEN------------
Q
K
--------------
P
L
--------------
F
D
----------
S
S
-
D
--
F
K
G
A
-------------
S
S
---------------------
T
I
P
V
-
A
R
W
I
D
A
I
L
EPG
K
T
I
D
A
NG
S
K
V
-----------
V
Y
P
D
---
I
K
M
M
I
F
S
G
N
N
P
W
N
H
H
Q
D
R
N
R
-
M
K
Q
A
-------------------------------
F
-
H
K
L
E
C
V
V
T
V
D
V
N
W
T
A
T
C
R
F
S
D
I
V
L
P
A
C
T
T
Y
E
R
N
D
--
I
--
D
--
V
Y
G
A
Y
A
-
N
--
R
G
I
L
A
M
Q
K
M
V
E
P
L
F
D
S
L
S
D
F
E
I
F
T
R
F
A
A
V
L
G
K
E
K
E
Y
-----------
T
--
R
----
N
----
M
G
--
E
--
M
------------------------------------------------
E
W
L
--
E
T
---
L
Y
----------------
N
E
C
----
K
--
A
A
N
AGK
F
--
E
---------------------------
M
----
P
D
F
A
T
F
W
K
Q
-
G
-------------
Y
-------------
V
H
---
F
G
-
D
G
E
-
V
----
W
T
R
H
--
A
D
F
R
N
-
D
P
E
I
N
P
L
G
T
P
S
G
L
I
E
I
F
S
R
K
I
D
Q
F
G
Y
D
D
C
K
G
H
P
T
W
M
E
K
T
E
R
S
-
H
G-------
G
P
G
S
D
K
H
P
I
W
L
Q
S
C
H
-
P
D
K
R
L
H
S
Q
M
C
E
S
R-
E
Y
R
E
T
Y
-
A
V
N
G
R
E
P
V
Y
I
S
P
V
D
A
K
A
R
G
I
K
D
G
D
I
V
R
V
F
N
D
R
G
Q
L
L
A
G
A
V
V
--
S
D
N
F
P
K
G
I
V
R
I
H
E
G
A
W
Y
G
P
V
G
K
--
D
-------
G
S
TEGGAEV
G
A
L
C
S
Y
G
D
---
P
N
T
L
T
L
D
-
I
G
T
S
K
----------------
L
A
Q
A
C
S
----------------
A
Y
T
-
C
L
V
E
F
E
K
Y
Q
G
K
V
P
K
V
S
S
F
D
G
P
------
35
HHSearch
73.20
19%
-58
- C3 -
4YDD
9
?
A:
[31-896]
---------
A
H
L
V
N
C
T
G
A
C
P
---
H
F
V
Y
S
K
-
D
G
V
V
M
R
E
E
Q
S
KDIAPMPN
I
-
P
---
E
Y
N
P
R
G
C
N
K
G
E
C
G
H
D
Y
M
Y
G
P
H
R
I
K
Y
P
L
I
R
V
G
-------------------------------------
E
R
G
E
G
K
W
R
R
A
T
W
E
E
A
L
D
M
I
A
D
K
C
V
D
T
I
K
N
H
A
P
D
C
I
S
V
Y
S
P
V
P
A
--
V
S
-
P
V
S
F
S
A
G
H
R
F
A
H
Y
I
G
A
--
H
A
H
T
-----
F
Y
D
W
Y
G
D
H
P
--
T
G
Q
T
--
Q
T
C
G
V
Q
-----
G
D
T
C
-
E
T
A
D
W
F
N
S
K
Y
I
I
L
W
G
S
N
P
T
Q
T
R
I
---
P
--------
D
-
A
---
H
F
L
S
E
A
-
Q
L
N
G
A
----
K
I
V
S
I
S
P
D
Y
N
S
S
T
I
-
K
V
------
D
K
W
I
H
P
Q
P
G
T
D
G
A
L
A
M
A
M
A
H
V
I
I
K
E
K
------
L
Y
D
A
H
S
L
K
E
Q
T
D
L
S
Y
L
V
R
SDTKRFLREADVVAGGSKD
K
F
Y
F
W
NAKTG
K
P
V
I
P
K
GSWGDQPE
K
K
G
S
P
VGFLGRNTFAFPKGYIDLGD
L
D
P
A
L
E
G
K
F
N
M
Q
L
LDG
K
T
V
E
V
R
P
V
F
E
I
L
K
S
R
------------------------------------------------------------------------------------------------------------------------------
L
----------------------------
M
A
D
N
T
P
E
K
A
A
K
I
T
G
V
T
A
K
A
I
T
E
L
A
R
E
F
A
T
--
A
-----
K
P
S
M
I
I
C
G
G
G
T
Q
H
W
Y
Y
S
D
V
L
L
R
A
M
H
L
L
T
A
L
T
G
T
E
G
T
N
G
G
G
M
---------
N
H
Y
I
-------------
G
Q
W
K
-
P
A
F
V
A
G
-
L
V
----
A
----
L
-
A
F
-
P
E
-----
G
V
---------------
N
K
Q
R
F
C
Q
T
--------
T
I
--------------
W
T
----------
Y
I
-
H
A
E
V
N
D
E
-------------
I
I
SSDID
T
E
K
Y
L
---------
R
D
S
I
T
T
-
G
Q
M
P
N
M
P
E
------------------------
Q
G
R
D
---
P
K
V
F
F
V
Y
R
G
N
W
L
N
Q
A
K
G
Q
K
Y
-
V
L
E
N
-------------------------------
L
W
P
K
L
E
L
I
V
D
I
N
I
R
M
D
S
T
A
L
Y
S
D
V
V
L
P
S
A
H
W
Y
E
K
L
D
--
L
--
N
--
V
---
T
S
-
E
H
-
S
Y
I
N
M
T
E
P
A
I
K
P
M
W
E
S
K
T
D
W
Q
I
F
L
A
L
A
K
R
V
E
M
A
A
K
R
-----------
K
KY
E
----
K
----
F
N
D
E
K
F
K
W
V-----------------------------------------------
R
D
L
--
S
N
---
L
W
N
Q
M
T
M
DGKLAE
D
E
A
A
A
Q
Y
I
L
D
N
A
P
--
Q
-----
S
--
K
---------------------------
G
----
I
T
I
Q
M
L
R
E
K
-
P
-------------
Q
-------------
R
F
KSN
W
T
-
S
P
L
K
E
----
G
V
P
Y
--
T
P
F
Q
Y
F
V
V
D
K
K
P
W
P
T
L
T
G
R
Q
Q
F
Y
L
D
H
D
T
F
F
--
D
M
G
V
E
L
P
T
Y
K
A
P
I
D
---------------
A
D
K
Y
P
F
R
F
N
S
P
H
-
S
R
H
S
V
H
S
T
F
K
D
N
V
L
M
L
R
L
Q
R
----
G
G
P
S
I
E
M
S
P
L
D
A
K
P
L
G
I
K
D
N
D
W
V
E
A
W
N
N
H
G
K
V
I
C
R
V
K
I
--
R
N
G
E
Q
R
G
R
V
S
M
W
H
C
P
E
L
Y
M
D
L
L
------------------------
T
G
G
---
S
Q
S
V
C
P
V
--
R
I
N
P
TNLVGNYGH
L
F
F
R
PNY
Y
G
P
A
G
S
----------------
Q
R
D
-
V
R
V
N
V
K
R
Y
I
G
A
T
P
--------------
37
HHSearch
72.96
19%
-55
- C3 -
1Q16
4
NARG_ECOLI
A:
[50-1229]
----------
H
G
V
N
C
T
G
S
C
S
---
W
K
I
Y
V
K
-
N
G
L
V
T
W
E
T
Q
Q
TDYPRTRP
D
L
P
---
N
H
E
P
R
G
C
P
R
G
A
S
Y
S
W
Y
L
Y
S
A
N
R
L
K
Y
P
M
M
R
K
R
L
M
K
M
W
R
E
A
K
A
L
H
SD
P
V
E
A
W
A
S
I
I
E
D
A
D
K
A
K
S
F
-
K
-
Q
-
A
R
G
R
G
G
F
V
R
S
S
W
Q
E
V
N
E
L
I
A
A
S
N
V
Y
T
I
K
N
Y
G
P
D
R
V
A
G
F
S
P
I
P
A
--
M
S
-
M
V
S
Y
A
S
G
A
R
Y
L
S
L
I
G
G
--
T
C
L
S
-----
F
Y
D
W
Y
C
D
L
P
P
--
A
S
P
--
Q
T
W
G
E
Q
-----
T
D
V
P
E
S
-
A
D
W
Y
N
S
S
Y
I
I
A
W
G
S
N
V
P
Q
T
R
T
---
P
--------
D
-
A
---
H
F
F
T
E
V
-
R
Y
K
G
T
----
K
T
V
A
V
T
P
D
Y
A
E
I
A
K
-
L
C
------
D
L
W
L
A
P
K
Q
G
T
D
A
A
M
A
L
A
M
G
H
V
M
L
R
E
F
HLDNPS
Q
Y
F
T
D
Y
V
R
R
Y
T
D
M
P
-------------------------------------------------------------------------------------------------
M
L
V
M
L
E
E
R
DGYYAAGRMLRAADLVDALGQENNPEW
K
T
V
A
F
N
TNG
E
M
V
A
P
N
GS
I
G
F
R
W
GEKGKWNLEQRDGKTG
E
E
T
E
L
Q
L
S
LLGSQD
E
I
A
E
V
G
F
P
Y
FGGDGTEH
F
N
K
V
E
L
E
N
V
L
L
H
K
L
P
V
K
R
L
Q
L
ADG
S
T
A
L
V
T
T
V
Y
D
L
T
L
A
N
Y
GLERGLNDVNCA
T
S
Y
D
D
V
K
A
Y
T
P
A
W
A
E
Q
I
T
G
V
S
R
S
Q
I
I
R
I
A
R
E
F
A
D
--
N
A
D
K
T
H
G
R
S
M
I
I
V
G
A
G
L
N
H
W
Y
H
L
D
M
N
Y
R
G
L
I
N
M
L
I
F
C
G
C
V
G
Q
S
G
G
G
W
---------
A
H
Y
V
-------------
G
Q
E
K
-
L
R
---
P
Q
T
G
W
Q
P
L
A
F
AL-
D
-
W
Q
R
P
A
-----
R
H
M
N
S
T
S
Y
F
Y
N
HSSQWR
Y
E
TVTAEELLSPMADK
S
R
Y
T
G
H
L
I
D
F
N
V
R
A
E
R
M
G
----------
W
L
P
S
--
A
P
Q
L
-------------
G
T
---------
N
PLT
I
A
G
E
A
E
K
A
G
M
N
P
V
D
Y
T
V
K
S
L
K
----------
E
-
G
SIRFAAEQPEN
G
K
N
H
---
P
R
N
L
F
I
W
R
S
N
L
L
G
S
S
G
K
G
H
E
F
M
L
K
Y
LLGTEHGIQGKDLGQQGGVKPEE
V
D
W
Q
DNGL
E
-
G
K
L
D
L
V
V
T
L
D
F
R
L
S
S
T
C
L
Y
S
D
I
I
L
P
T
A
T
W
Y
E
K
D
D
--
M
--
N
--
T
---
S
D
M
H
--
P
F
I
H
P
L
S
A
A
V
D
P
A
W
E
A
K
S
D
W
E
I
Y
K
A
I
A
K
K
F
S
E
V
C
V
G
HLGK
E
T
D
I
V
T
L
P
IQ
H
DSAA
E
LAQP
L
D
V
K
D
W
-
K
KGECDLIPGKTA
P
H
I
M
V
V
E
R
DYPA
T
Y
E
R
F
T
S
IGP
L
M
E
K
I
GNGGKG
I
A
W
N
T
Q
S
E
M
D
---
L
L
----------------
R
K
L
----
N
--
Y
-----
T
KA
E
GPAKGQPMLNT
A
I
D
A
A
E
M
I
L
T
L
APETN
G
Q
V
A
V
K
A
W
A
A
L
S
E
F
T
G
RDHTHLALNKED
E
K
I
R
F
R
D
I
Q
A
Q
P
R
K
I
I
S
---
S
P
-
T
W
S
-
G
LEDE
H
V
S
Y
--
N
A
G
Y
T
N
V
H
E
L
I
P
W
R
T
L
S
G
R
Q
Q
L
Y
Q
D
H
Q
W
M
R
D
--
F
G
E
S
L
L
V
Y
R
P
P
I
D
T
R
-
S
VKEVIGQK
S
N
G
N
Q
E
K
A
L
N
F
L
T
P
H
-
Q
K
W
G
I
H
S
T
Y
S
D
N
L
L
M
L
T
L
G
R
----
G
G
P
V
V
W
L
S
E
A
D
A
K
D
L
G
I
A
D
N
D
W
I
E
V
F
N
S
N
G
A
L
T
A
R
A
V
V
--
S
Q
R
V
P
A
G
M
T
M
M
Y
H
A
Q
E
R
I
V
N
L
P
--
G
-------
S
E
-------
I
T
Q
Q
R
G
G
I
---
H
N
S
V
T
R
I
--
T
P
K
P
----------------
T
H
M
I
G
G
YAHLAYGFNYYGTVGS
N
R
D
-
E
F
V
V
V
R
K
M
K
------------------
58
Fugue
72.37
21%
-63
- C3 -
2VPZ
4
?
A:
[30-763]
APWYA
Q
E
V
K
S
V
Y
Q
I
C
E
G
C
F
W
R
C
G
I
V
A
H
A
V
-
G
N
R
V
Y
K
V
E
G
Y
E
ANP----
K
-
S
---
R
G
R
L
C
P
R
--
G
Q
G
A
P
Q
T
T
Y
D
P
D
R
L
K
R
P
L
I
R
V
E
---------------------------------
G
-
S
-
Q
R
G
E
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
F
G
H
G
-----------
T
G
D
Y
W
F
V
D
F
L
P
A
--
A
W
G
S
P
N
A
A
K
P
S
V
S
L
C
T
A
P
R
E
V
A
S
Q
W
V
F
G
R
P
I
G
-----
G
-
H
E
-
P
-
I
D
W
E
N
A
R
Y
I
V
L
I
G
H
H
I
------------
G
E
D
T
H
N
T
Q
L
--
Q
D
F
A
L
A
-
L
K
N
G
A
----
K
V
V
V
V
D
P
R
F
S
T
A
A
A
-
K
A
H
------
R
W
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
D
------
L
Y
D
K
E
Y
V
A
K
Y
T
V
G
F
-------------------------------------------------------------------------------------------------
E
E
L
K
A
H
------------------------------------------------------------------------------------------------------------------------------
V
-----------------------
K
------
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
-
A
A
H
K
-----
P
R
A
V
L
P
P
T
R
H
N
V
W
Y
G
D
D
T
Y
R
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
G
R
P
G
G
F
Y
I
A
Q
S
P
Y
L
E
K
Y
P
L
P
-------------
P
L
P
L
-
E
P
---
A
-
A
G
G
---
C
----
S
-
G
P
-
S
G
-----
G
D
--------------------------------
H
--------------
E
P
----------
E
G
-
F
--
K
P
R
A
-------------
D
K
---------
G
---------
K
F
F
A
R
S
-
T
A
I
Q
E
L
I
E
----------
P
-
M
-----------
I
T
G
E
PY
P
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
R
-
T
K
E
A
-------------------------------
L
-
K
N
L
D
L
Y
V
A
I
D
V
L
P
Q
E
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
--
L
--
V
---
A
H
-
K
T
-
P
F
I
Q
L
R
T
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A
H
E
P
L
F
D
T
K
P
G
W
W
I
A
R
E
L
G
L
R
L
G
L
E
Q
Y
F
-----------
P
--
W
-----------------------------------------------------------------
K
T
I
--
E
E
---
Y
L
----------------
E
T
R
----
L
--
Q
-----
S
--
L
---------------------------
G
----
L
D
L
E
T
M
K
G
M
-
G
-------------
T
-------------
L
V
---
Q
R
G
K
P
W
-
L
----
E
D
W
E
--
K
E
G
R
L
-
P
F
-----
G
T
A
S
G
K
I
E
L
Y
C
Q
R
F
K
E
A
G
H
Q
P
L
---
P
V
F
T
P
P
E
E
P
P
-
E
--------
G
F
----
Y
R
L
L
Y
G
-----
R
S
P
V
H
T
F
A
R
T
Q
--
N
N
W
V
L
M
-
E
M
D
P
E
N
E
V
W
I
H
K
E
E
A
K
R
L
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L
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M
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D
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K
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P
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V
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T
A
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I
R
K
D
C
V
Y
I
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H
G
F
G
H
K
A
P
L
M
--
R
-------------------
L
A
H
G
R
GAS
D
N
Y
L
Q
T
R
Y
K
L
D
P
I
----------------
S
G
G
A
G
L
----------------
R
V
N
-
F
-
V
R
L
E
K
A
E
R
P
R
L
P
S
L
T
G
L
A
K
R
P
F
D
ER
31
HHSearch
71.69
20%
-60
- C3 -
2E7Z
8
AHY_PELAE
A:
[4-727]
---------
V
V
C
Q
S
C
D
I
N
C
V
---
V
E
A
E
V
K
A
D
G
K
I
Q
T
K
S
I
S
--------
E
-
P
HPT
T
P
P
N
S
I
C
M
K
S
V
N
A
D
T
I
R
T
H
K
D
R
V
L
Y
P
L
K
N
V
G
-----------------------------------
S
-
K
R
G
E
Q
R
W
E
R
I
S
W
D
Q
A
L
D
E
I
A
E
K
L
K
K
I
I
A
K
Y
G
P
E
S
L
G
V
S
Q
T
E
I
N
--
Q
Q
-
S
E
Y
G
T
L
-
R
R
F
M
N
L
L
G
S
--
P
N
W
T
-----
S
A
M
Y
M
C
I
G
N
T
A
G
V
H
R
--
V
T
H
G
S
Y
-----
S
----
F
-
A
S
F
A
D
S
N
C
L
L
F
I
G
K
N
L
S
N
H
N
W
---
V
--------
S
-
Q
F
--
N
D
L
K
A
A
-
L
K
R
G
C
----
K
L
I
V
L
D
P
R
R
T
K
V
A
E
-
M
A
------
D
I
W
L
P
L
R
Y
G
T
D
A
A
L
F
L
G
M
I
N
V
I
I
N
E
Q
------
L
Y
D
K
E
F
V
E
N
W
C
V
G
F
-------------------------------------------------------------------------------------------------
E
E
L
K
E
R
------------------------------------------------------------------------------------------------------------------------------
V
-----------------------
Q
------
E
Y
P
L
D
K
V
A
E
I
T
G
C
D
A
G
E
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R
K
A
A
V
M
F
A
T
--
E
-----
S
P
A
S
I
P
W
A
V
S
T
D
M
Q
K
N
S
C
S
A
I
R
A
Q
C
I
L
R
A
I
V
G
S
F
V
N
-
G
A
E
I
---------
L
G
A
P
-------------
H
S
D
L
V
P
I
S
--
K
-
I
Q
M
---
H
----
E
-
A
L
-
P
E
-----
E
K
---------------
K
K
--------------
L
Q
--------------
L
G
----------
T
E
-
T
--
Y
P
F
L
TYTGMSAL
E
E
P
S
E
R
V
YGVKY----
F
HNMG-----
A
F
M
A
N
P
-
T
A
L
F
T
A
M
A
----------
T
-
E
-----------
K
P
Y
P
---
V
K
A
F
F
A
L
A
S
N
A
L
M
G
Y
A
N
Q
Q
N
-
A
L
K
G
-------------------------------
L
-
M
N
Q
D
L
V
V
C
Y
D
Q
F
M
T
P
T
A
Q
L
A
D
Y
V
L
P
G
D
H
W
L
E
R
P
V
--
V
--
Q
--
P
---
N
W
-
E
G
I
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F
G
N
T
S
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Q
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V
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A
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D
E
Y
Y
F
I
R
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L
A
V
R
M
G
L
E
E
------------------------------
H
F
P
W
------------------------------------------------
K
D
R
--
L
E
---
L
I
----------------
N
Y
R
----
I
--
S
-----
P
--
T
---------------------------
G
----
M
E
W
E
E
Y
Q
K
Q
-
Y
-------------
T
-------------
Y
M
---
S
K
-
L
P
D
------
Y
--
F
--------
G
P
E
G
V
G
V
A
T
P
S
G
K
V
E
L
Y
S
S
V
F
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K
L
---
G
Y
D
P
L
P
Y
Y
H
E
P
L
Q
T
E
-
I
SD------
P
E
L
A
K
E
Y
P
L
I
L
F
A
G
L
R
E
D
S
N
F
Q
S
C
Y
H
Q
P
G-
I
L
R
D
A
E
----
P
D
P
V
A
L
L
H
P
K
T
A
Q
S
L
G
L
P
S
G
E
W
I
W
V
E
T
T
H
G
R
L
K
L
L
L
K
H
--
D
G
A
Q
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G
T
I
R
I
P
H
G
R
W
C
P
E
Q
E
G
GP
E
-------
T
G
-------
F
S
G
A
M
L
H
N
D--
A
M
V
L
S
D
D
D
W
N
L
D
P
----------------
E
Q
G
L
P
N
----------------
L
R
G
G
I
L
A
K
A
Y
K
C
-------------------