@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1739c: (2016-05-04 )
MIPTMTSAGWAPGVVQFREYQRRWLRGDVLAGLTVAAYLIPQAMAYATVAGLPPAAGLWASIAPLAIYALLGSSRQLSIGPESATALMTAAVLAPMAAGDLRRYAVLAATLGLLVGLICLLAGTARLGFLASLRSRPVLVGYMAGIALVMISSQLGTITGTSVEGNEFFSEVHSFATSVTRVHWPTFVLAMSVLALLTMLTRWAPRAPGPIIAVLAATMLVAVMSLDAKGIAIVGRIPSGLPTPGVPPVSVEDLRALIIPAAGIAIVTFTDGVLTARAFAARRGQEVNANAELRAVGACNIAAGLTHGFPVSSSSSRTALADVVGGRTQLYSLIALGLVVIVMVFASGLLAMFPIAALGALVVYAALRLIDLSEFRRLARFRRSELMLALATTAAVLGLGVFYGVLAAVALSILELLRRVAHPHDSVLGFVPGIAGMHDIDDYPQAKRVPGLVVYRYDAPLCFANAEDFRRRALTVVDQDPGQVEWFVLNAESNVEVDLTALDALDQLRTELLRRGIVFAMARVKQDLRESLRAASLLDKIGEDHIFMTLPTAVQAFRRR
Atome Classification :
(20 SA)
----------------------------.........10........20.---.-------------..---....30...------.....---------40.......----.50.------.......60........70-........80........90----........100.......110.......120...----....130.......140.......150.......160....---...170.......180....---...190.......200...---------...---.---------210.......220.......230.----------.....-.240.....--.------.--250.......260-.......270.......280.---.----.....290------------.......300.......310.......320..----..-----...330....--------------...340-----...--....350.......360.-------......370....----------------------...380.......-390..-....-----------.400........410.......420.......430....-...440.......450........460.......470.....-..480........490.....-..500.....-..510.......520.......530.......-540--.....-....550------------------........560----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------MIPTMTSAGWA
P
G
V
V
Q
F
R
E
Y
Q
R
---
R
-------------
W
L---R
G
D
V
L
A
G
L
T
------
V
A
A
Y
L
---------
I
P
Q
A
M
A
Y
A
T
----VAGL------PP
A
A
G
L
W
A
S
I
A
P
L
A
I
Y
A
L
L-GSS
R
Q
LSIGP
E
S
A
T
A
L
M
T
A
A
----
V
L
A
P
M
A
A
G
D
L
R
R
Y
A
V
L
A
A
T
L
G
L
L
V
G
L
I
C
L
L
AG
T
A
----
R
L
G
F
L
A
S
LRSR
P
V
L
V
G
Y
M
A
G
I
A
L
V
M
ISSQLG
T
I
TGTSVE
G
N
---
E
F
F
S
E
V
H
S
F
A
T
S
V
T
RVH
W
P
T
---
F
V
L
A
M
S
V
L
A
L
L
T
M
L
T
R
WAP---------RAP---
G
---------
P
I
I
A
V
L
A
A
T
M
L
V
A
V
M
SLDAK
G
I
A
I
----------
V
GRIP-SGLPTPGVP--P------V--
S
V
E
D
L
R
A
L
I
IPAA-
G
I
A
I
V
T
FTD
G
V
L
T
A
R
A
F
A
A
RR---G----QEVNANA
E
------------
L
R
A
V
GA
C
N
I
A
AGLTHGFPVSSSSS
R
T
A
L
A
D
V
V----G
G
-----
R
T
Q
L
Y
S
L
I
A
L
--------------
G
L
V
V
I
V
-----
M
V
F
--
A
S
G
L
L
A
M
F
P
I
A
A
L
G
A
L
V
V
-------
Y
A
A
L
R
LI
D
L
S
E
F
R
----------------------
R
L
A
R
F
R
R
S
E
L
M
L
A
-
L
A
T
T
A
-
A
V
L
G
-----------
L
G
-
V
F
Y
G
V
L
A
A
V
A
L
S
I
L
E
L
L
R
R
VAHPH
D
S
V
L
G
F
VPGIAG-MHDIDDYPQAKRVP-
G
L
V
V
Y
RYDA
P
L
C
FA
N
A
E
D
F
R
R
R
A
L
T
V
V-DQD-PG
Q
V
E
W
F
V
LNAESN
V
E
V
-
D
L
T
A
L
D
A
L
D
Q
-
L
R
T
E
L
L
R
R
G
I
V
F
A
M
A
R
V
K
Q
D
L
R
E
S
L
R
A
A
S
L
L
D
-
K
----IGED
H
-
I
F
M
T
L
P
-------------------
T
A
V
Q
A
F
RRR------
36
Fugue
86.84
27%
-122
- C2 -
5DA0
2
?
A:
[14-484]
------------------------------------------------
Q
R
---
E
-------------
W
F
AN
P
R
K
D
V
L
A
G
I
V
------
V
A
L
A
L
---------
I
P
E
A
I
A
F
S
I
----
I
A
G
V
------
D
P
Q
V
G
L
Y
A
S
F
I
I
A
L
I
T
A
F
L
-
G
G
R
P
G
M
I
S
A
A
T
G
A
M
A
L
L
M
T
G
----
L
V
K
D
H
G
I
Q
Y
L
F
A
A
T
V
L
T
G
V
L
Q
V
V
F
G
W
-------
A
----
K
L
A
R
Y
L
K
F
V
P
R
S
V
M
V
G
F
V
N
A
L
A
I
L
I
F
M
A
Q
L
P
Q
F
V
G
A
N
------------------------
W
Q
M
---
Y
A
M
V
A
A
G
L
A
I
I
Y
L
L
P
L
V
F
K
---------
A
M
P
---
S
---------
A
L
V
A
I
V
V
L
T
V
V
A
V
V
T
G
A
D
V
K
T
V
G
D
----------
M
G
T
L
P
-
T
A
L
P
H
F
Q
F
P
QV
P
------
L
--
T
F
E
T
L
A
I
I
F
P
V
A
L
-
T
L
S
L
V
G
L
L
E
S
L
L
T
A
Q
L
I
D
E
R
T
---
D
----
T
T
S
D
K
N
V
E
------------
S
R
G
Q
G
V
A
N
I
V
T
G
F
F
G
G
M
A
G
C
A
M
I
G
Q
S
M
I
N
V
T
S
----
G
G
-----
R
G
R
L
S
T
F
V
A
G
--------------
A
F
L
M
V
L
-----
I
L
A
--
L
Q
P
L
L
V
Q
I
P
M
A
A
L
V
A
V
M
M
-------
V
V
A
I
S
T
F
D
W
G
S
L
R
--------------------------
F
P
K
G
E
T
V
V
M
-
L
A
T
V
A
-
V
T
V
F
-----------
T
H
D
L
S
L
G
V
L
I
G
V
V
L
S
A
L
F
F
A
R
K
V
S
Q
------------------
L
S
Q
V
T
P
V
D
E
V
D
-
G
T
R
T
Y
R
V
R
G
Q
L
F
F
V
S
T
H
D
F
L
H
Q
----
F
-
D
F
T
-
H
P
A
R
R
V
V
I
D
L
S
D
A
H
F
-
W
-
D
G
S
A
V
G
A
L
D
K
-
V
M
L
K
F
M
R
Q
G
T
S
V
E
L
R
G
L
N
A
------
A
S
A
T
L
V
E
-
R
----
L
---------------------------------------------
2
PsiBlast_PDB
86.68
26%
-125
- C2 -
5DA0
2
?
A:
[14-465]
------------------------------------------------
Q
R
---
E
-------------
W
F
AN
P
R
K
D
V
L
A
G
I
V
------
V
A
L
A
L
---------
I
P
E
A
I
A
F
S
I
----
I
A
G
V
------
D
P
Q
V
G
L
Y
A
S
F
I
I
A
L
I
T
A
F
L
-
G
G
R
P
G
M
I
S
A
A
T
G
A
M
A
L
L
M
T
G
----
L
V
K
-----
D
H
G
I
Q
Y
L
F
A
A
T
V
--
L
T
G
V
L
Q
V
V
F
G
W
A
----
K
L
A
R
Y
L
K
F
V
P
R
S
V
M
V
G
F
V
N
A
L
A
I
L
I
F
M
A
Q
L
P
Q
F
V
G
A
------------------------
N
W
Q
M
---
Y
A
M
V
A
A
G
L
A
I
I
Y
L
L
P
L
V
F
K
---------
A
M
P
---
S
---------
A
L
V
A
I
V
V
L
T
V
V
A
V
V
T
G
A
D
V
K
T
V
G
D
----------
M
G
T
L
P
-
T
A
L
P
H
F
Q
F
P
QV
P
------
L
--
T
F
E
T
L
-
A
I
I
F
P
V
A
L
T
L
S
L
V
G
L
L
E
S
L
L
T
A
Q
L
I
D
E
R
T
---
D
----
T
T
S
D
K
N
V
E
------------
S
R
G
Q
G
V
A
N
I
V
T
G
F
F
G
G
M
A
G
C
A
M
I
G
Q
S
M
I
N
V
T
S
----
G
G
-----
R
G
R
L
S
T
F
V
A
G
--------------
A
F
L
M
V
L
-----
I
L
A
--
L
Q
P
L
L
V
Q
I
P
M
A
A
L
V
A
V
M
M
-------
V
V
A
I
S
T
F
D
W
G
S
L
R
--------------------------
F
P
K
G
E
T
V
V
M
-
L
A
T
V
A
V
T
V
F
T
-----------
H
D
-
L
S
L
G
V
L
I
G
V
V
L
S
A
L
F
F
A
R
K
V
S
Q
-----------
L
S
Q
-
V
T
P
V
D
E
------
V
D
-
G
T
R
T
Y
R
V
R
G
Q
L
F
F
V
S
T
H
D
F
L
H
Q
F
------
D
F
-
T
H
P
A
R
R
V
V
I
D
L
S
D
A
H
F
W
-
D
G
S
A
V
G
A
L
D
K
-
V
M
L
K
F
M
R
Q
G
---------------------------------------------------------------------------
14
HHSearch
86.27
25%
-120
- C2 -
5DA0
2
?
A:
[14-484]
------------------------------------------------
Q
R
EWF
A
-------------
N
P
---
R
K
D
V
L
A
G
I
V
------
V
A
L
A
L
---------
I
P
E
A
I
A
F
S
I
----
I
A
G
V
------
D
P
Q
V
G
L
Y
A
S
F
I
I
A
L
I
T
A
F
L
-
G
G
R
P
G
M
I
S
A
A
T
G
A
M
A
L
L
M
T
G
----
L
V
K
D
-------
H
G
I
Q
Y
L
F
A
A
T
V
L
T
G
V
L
Q
V
V
F
G
W
A
----
K
L
A
R
Y
L
K
F
V
P
R
S
V
M
V
G
F
V
N
A
L
A
I
L
I
F
M
A
Q
L
P
Q
F
V
G
A
N
W
Q
------------------------
M
---
Y
A
M
V
A
A
G
L
A
I
I
Y
L
L
P
L
V
F
K
---------
A
M
P
---
S
---------
A
L
V
A
I
V
V
L
T
V
V
A
V
V
T
G
A
D
V
K
T
V
G
D
----------
M
G
T
L
P
-
T
A
L
P
H
F
Q
F
P
--
Q
------
V
PL
T
F
E
T
L
A
I
I
F
P
V
A
L
-
T
L
S
L
V
G
L
L
E
S
L
L
T
A
Q
L
I
D
E
R
T
---
D
----
T
T
S
D
K
N
V
E
------------
S
R
G
Q
G
V
A
N
I
V
T
G
F
F
G
G
M
A
G
C
A
M
I
G
Q
S
M
I
N
V
T
S
----
G
G
-----
R
G
R
L
S
T
F
V
A
G
--------------
A
F
L
M
V
L
-----
I
L
A
--
L
Q
P
L
L
V
Q
I
P
M
A
A
L
V
A
V
M
M
-------
V
V
A
I
S
T
F
D
W
G
S
L
R
--------------------------
F
P
K
G
E
T
V
V
M
-
L
A
T
V
A
-
V
T
V
F
T
----------
H
D
-
L
S
L
G
V
L
I
G
V
V
L
S
A
L
F
F
A
R
K
V
S
Q
L
S
Q
V
T
------------------
P
V
D
E
V
D
-
G
T
R
T
Y
R
V
R
G
Q
L
F
F
V
S
T
H
D
F
L
H
Q
F
D
F
T
-------
H
P
A
R
R
V
V
I
D
L
S
D
A
H
F
W
-
D
G
S
A
V
G
A
L
D
K
-
V
M
L
K
F
M
R
Q
G
T
S
V
E
L
R
G
L
N
A
A
S
A
T
L
V
E
R
L
--------------------------------------------------------
3
PsiBlast_PDB
75.12
28%
-126
- C2 -
5IOF
-
?
A:
[14-391]
------------------------------------------------
Q
R
---
E
-------------
W
F
AN
P
R
K
D
V
L
A
G
I
V
------
V
A
L
A
L
---------
I
P
E
A
I
A
F
S
I
----
I
A
G
V
------
D
P
Q
V
G
L
Y
A
S
F
I
I
A
L
I
T
A
F
L
-
G
G
R
P
G
M
I
S
A
A
T
G
A
M
A
L
L
M
T
G
----
L
V
K
-----
D
H
G
I
Q
Y
L
F
A
A
T
V
--
L
T
G
V
L
Q
V
V
F
G
W
A
----
K
L
A
R
Y
L
K
F
V
P
R
S
V
M
V
G
F
V
N
A
L
A
I
L
I
F
M
A
Q
L
P
Q
F
V
G
A
------------------------
N
W
Q
M
---
Y
A
M
V
A
A
G
L
A
I
I
Y
L
L
P
L
V
F
K
---------
A
M
P
---
S
---------
A
L
V
A
I
V
V
L
T
V
V
A
V
V
T
G
A
D
V
K
T
V
G
D
----------
M
G
T
L
P
-
T
A
L
P
H
F
Q
F
P
QV
P
------
L
--
T
F
E
T
L
-
A
I
I
F
P
V
A
L
T
L
S
L
V
G
L
L
E
S
L
L
T
A
Q
L
I
D
E
R
T
---
D
----
T
T
S
D
K
N
V
E
------------
S
R
G
Q
G
V
A
N
I
V
T
G
F
F
G
G
M
A
G
C
A
M
I
G
Q
S
M
I
N
V
T
S
----
G
G
-----
R
G
R
L
S
T
F
V
A
G
--------------
A
F
L
M
V
L
-----
I
L
A
--
L
Q
P
L
L
V
Q
I
P
M
A
A
L
V
A
V
M
M
-------
V
V
A
I
S
T
F
D
W
G
S
L
R
--------------------------
F
P
K
G
E
T
V
V
M
-
L
A
T
V
A
V
T
V
F
T
-----------
H
D
-
L
S
L
G
V
L
I
G
V
V
L
S
A
L
F
F
A
R
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
67.26
100%
-39
- C2 -
2KLN
-
?
A:
[1-124]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
D
I
D
D
Y
P
Q
A
K
R
V
P
-
G
L
V
V
Y
R
Y
D
A
P
L
C
F
A
N
A
E
D
F
R
R
R
A
L
T
V
V
-
D
Q
D
-
P
G
Q
V
E
W
F
V
L
N
A
E
S
N
V
E
V
-
D
L
T
A
L
D
A
L
D
Q
-
L
R
T
E
L
L
R
R
G
I
V
F
A
M
A
R
V
K
Q
D
L
R
E
S
L
R
A
A
S
L
L
D
-
K
----
I
G
E
D
H
-
I
F
M
T
L
P
-------------------
T
A
V
Q
A
F
R
R
R
------
1
PsiBlast_PDB
67.20
100%
-39
- C2 -
2KLN
-
?
A:
[1-124]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
D
I
D
D
Y
P
Q
A
K
R
V
P
-
G
L
V
V
Y
R
Y
D
A
P
L
C
F
A
N
A
E
D
F
R
R
R
A
L
T
V
V
-
D
Q
D
-
P
G
Q
V
E
W
F
V
L
N
A
E
S
N
V
E
V
-
D
L
T
A
L
D
A
L
D
Q
-
L
R
T
E
L
L
R
R
G
I
V
F
A
M
A
R
V
K
Q
D
L
R
E
S
L
R
A
A
S
L
L
D
-
K
----
I
G
E
D
H
-
I
F
M
T
L
P
-------------------
T
A
V
Q
A
F
R
R
R
------
17
HHSearch
66.12
100%
-39
- C2 -
2KLN
-
?
A:
[8-124]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
A
K
R
V
P
-
G
L
V
V
Y
R
Y
D
A
P
L
C
F
A
N
A
E
D
F
R
R
R
A
L
T
V
V
-
D
Q
D
-
P
G
Q
V
E
W
F
V
L
N
A
E
S
N
V
E
V
-
D
L
T
A
L
D
A
L
D
Q
-
L
R
T
E
L
L
R
R
G
I
V
F
A
M
A
R
V
K
Q
D
L
R
E
S
L
R
A
A
S
L
L
D
-
K
----
I
G
E
D
H
-
I
F
M
T
L
P
-------------------
T
A
V
Q
A
F
R
R
R
------
42
Fugue
64.23
20%
-99
* C1 *
4UIR
3
OLHYD_ELIME
A:
[2-646]
NPITSKF
D
K
V
L
N
A
SSEYGHVNHEPDSSK
E
Q
Q
R
N
T
P
Q
K
S
M
P
F
S
D
Q
I
G
N
Y
Q
R
---
N
K
G
I
P
VQSYDN
S
K
I
Y
I
---
I
G
S
G
I
A
G
M
S
------
A
A
Y
Y
F
---------
I
R
D
G
H
V
P
A
K
N
I
T
F
L
E
Q
L
------
H
I
D
G
G
S
L
D
G
A
G
N
P
T
D
G
Y
I
I
-
R
G
G
R
E
M
D
M
T
Y
E
N
L
W
D
M
F
Q
D
I
PALE
M
P
A
P
Y
S
V
L
D
E
Y
R
L
I
N
D
N
D
S
N
Y
S
K
A
R
L
I
N
N
K
G
E
I
K
----
D
F
-------
S
K
F
G
L
N
K
M
D
Q
L
A
I
I
R
L
L
L
K
N
K
E
E
L
D
D
L
T
I
E
-----
D
Y
F
S
--
E
S
F
L
K
S
N
F
W
T
F
W
R
T
M
F
A
F
E
N
W
H
S
L
L
E
L
K
L
Y
M
H
R
F
L
H
---------
A
I
D
---
G
LNDLSS
L
V
F
P
K
Y
N
Q
Y
D
T
F
V
T
P
L
R
K
F
L
Q
E
K
G
V
N
I
H
L
NTLVK
D
L
D
I
H
I
N
T
-
E
G
K
V
V
E
G
I
----------
I
--
T
E
Q
D
G
K
E
V
K
I
P
V
G
-
K
N
D
Y
V
I
V
T
T
G
S
M
T
E
D
T
F
Y
G
N
N
---
K
----
T
A
P
I
I
G
I
D
NSTSGQSA
G
W
K
L
W
K
N
L
A
A
K
S
E
I
F
G
K
P
E
K
F
C
S
N
I
E
K
S
A
W
E
S
A
T
L
T
----
C
K
-----
P
S
A
L
I
D
K
L
K
E
Y
SVNDPYSGKTVTG
G
I
I
T
I
T
DSNWL
M
S
F
--
T
C
N
R
Q
P
H
F
P
E
Q
P
D
D
V
L
V
L
-------
W
V
Y
A
L
F
M
D
K
E
G
N
Y
----------------------
I
K
K
T
M
L
E
C
T
G
D
E
I
-
L
A
E
L
C
-
Y
H
L
G
--------------------------
I
E
D
Q
L
E
N
V
Q
K
N
T
I
V
R
T
A
F
M
P
Y
I
T
S
-
M
F
-------
M
P
R
A
K
-
G
------
D
R
P
R
V
V
P
E
----
G
C
K
N
L
G
L
V
-
G
Q
F
-
V
E
T
N
N
D
V
V
F
T
M
E
S
S
V
R
T
-
A
R
I
A
V
Y
K
L
L
N
-
L
N
K
Q
------
V
P
D
I
N
P
L
Q
Y
D
I
R
H
L
L
K
A
A
K
T
L
N
-
D
DKPF
V
G
E
G
L
-
L
R
K
V
L
K
GTYFEHVLPAGEEHESF
I
A
E
H
V
N
K
F
R
E
W
V
K
G
IRG
38
Fugue
59.60
21%
-97
- C2 -
3MGL
6
?
A:
[2-129]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
S
Y
E
L
A
Q
H
G
R
S
T
L
P
R
-
E
L
A
V
Y
A
L
E
G
P
F
F
F
A
A
A
E
T
F
E
R
-----
V
M
G
S
I
-
Q
E
T
P
Q
I
L
I
L
R
L
K
W
-
V
P
F
M
D
I
T
G
I
Q
T
L
E
E
M
I
-
Q
S
F
H
K
R
G
I
K
V
L
I
S
G
A
N
S
R
V
S
Q
K
L
V
K
A
G
I
V
K
-
L
----
V
G
E
Q
N
-
V
Y
P
V
F
E
-------------------
G
A
L
S
A
A
L
T
E
I
E
A
Q--
37
Fugue
57.67
21%
-90
- C2 -
3LLO
1
A:
[1-143]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Y
T
V
L
G
Q
L
P
D
T
D
V
-
Y
I
D
I
D
A
Y
E
E
V
K
E
I
P
-
G
I
K
I
F
Q
I
N
A
P
I
Y
Y
A
N
S
D
L
Y
S
S
A
N
I
------------
H
T
V
I
L
D
F
T
Q
V
N
F
M
-
D
S
V
G
V
K
T
L
A
G
-
I
V
K
E
Y
G
D
V
G
I
Y
V
Y
L
A
G
C
S
A
Q
V
V
N
D
L
T
S
N
R
F
F
E
-
N
----
P
A
L
K
E
L
L
F
H
S
I
H
-------------------
D
A
V
L
G
S
Q
V
R
EA----
21
HHSearch
57.38
18%
-99
- C2 -
4DGF
3
?
A:
[17-127]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
V
P
L
-
G
V
E
I
Y
E
I
N
G
P
F
F
F
G
V
A
D
R
L
K
G
V
L
D
V
I
E
------
E
T
P
K
V
F
I
L
R
M
R
R
V
P
V
I
-
D
A
T
G
M
H
A
L
W
E
-
F
Q
E
S
C
E
K
R
G
T
I
L
L
L
S
G
V
S
D
R
L
Y
G
A
L
N
R
F
G
F
I
E
-
A
----
L
G
E
E
R
-
V
F
D
H
I
D
-------------------
K
A
L
A
Y
A
K
L
-------
15
HHSearch
56.20
16%
-116
- C2 -
4YZF
1
B3AT_HUMAN
A:
[388-877]
-----------------------------------------------
R
R
Y
---
P
-------------
Y
Y
---
L
S
D
I
T
D
A
F
S
------
P
Q
V
L
A
A
V
I
F
I
Y
F
A
A
L
S
P
A
I
T
F
G
G
----
L
L
G
E
K
T
RNQM
G
V
S
E
L
L
I
S
T
A
V
Q
G
I
L
F
A
L
L
-
G
A
Q
P
L
L
V
V
G
F
S
G
P
L
L
V
F
E
E
A
----
F
-
F
S
F
C
E
T
N
G
L
E
Y
I
V
G
R
V
W
I
G
F
W
L
I
L
L
V
V
L
V
V
A
F
----
E
G
S
F
L
V
R
F
I
S
R
Y
T
Q
E
I
F
S
F
L
I
S
L
I
F
I
Y
E
T
F
S
K
L
I
K
I
F
Q
D
H
P
L
Q
K
T
Y
----------
L
P
N
T
A
L
L
S
---
L
V
L
M
A
G
T
F
F
F
A
M
M
L
R
K
F
K
N
SSYFPG
K
L
R
R
V
I
G
D
F
G
---------
V
P
I
S
I
L
I
M
V
L
V
D
F
F
I
Q
D
T
--
Y
T
Q
K
----------
L
-
S
V
P
-
D
G
F
K
V
-
V
I
H
--
P
LGLRSE
F
--
P
I
W
M
M
F
A
S
A
L
P
A
L
-
L
V
F
I
L
I
F
L
E
S
Q
I
T
T
L
I
V
S
K
P
E
RKM
V
----
K
G
S
G
F
H
L
D
------------
L
L
L
V
V
G
M
G
G
V
A
A
L
F
G
M
P
W
L
S
A
T
T
V
R
S
V
T
H
A
N
A
L
TVM--I
Q
E
V
K
E
Q
R
I
S
G
L
L
V
A
--------------
V
L
V
G
L
S
-----
I
L
---
M
E
P
I
L
S
R
I
P
L
A
V
L
F
G
I
F
L
-------
Y
M
G
V
T
S
L
S
G
I
Q
L
F
D
R
I
L
L
L
F
KPPKYHPDV
P
Y
V
K
R
V
K
T
W
R
M
H
L
F
T
G
I
Q
I
I
C
L
A
V
L
-
W
V
V
K
-----------
S
T
-
P
-
A
S
L
A
L
P
F
V
L
I
L
T
V
P
L
R
R
V
L
L
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
56.09
20%
-101
* C2 *
5EZB
2
?
A:
[24-140]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
K
E
Y
P
-
G
I
K
I
F
Q
A
N
T
S
L
Y
F
A
N
S
E
S
Y
T
S
A
L
K
K
K
T
-
G
V
D
G
S
T
N
V
H
S
L
I
L
D
F
A
P
V
N
F
V
-
D
S
V
G
A
K
T
L
K
S
-
V
I
K
E
Y
N
E
V
G
V
C
V
C
I
A
S
C
S
G
P
V
M
N
E
L
T
R
L
N
F
F
D
N
T
----
V
T
R
E
L
-
L
F
H
S
I
H
-------------------
D
A
V
L
A
C
Q
G
-------
16
HHSearch
55.30
17%
-117
- C2 -
3QE7
2
URAA_ECOLI
A:
[12-410]
-----------------------------------------------------
P
-------------
P
L
---
L
Q
T
I
P
L
S
L
Q
H
L
F
A
M
F
G
A
T
V
L
---------
V
P
V
L
F
H
----------
I
------
N
P
A
T
V
L
L
F
N
G
I
G
T
L
L
Y
L
F
I
C
K
G
K
I
P
A
Y
L
G
S
S
F
A
F
I
S
P
V
L
L
----
L
L
P
--------
L
G
Y
E
V
A
L
G
G
F
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
T
G
W
L
D
V
L
F
P
P
A
A
M
G
A
I
V
A
V
I
G
L
E
L
A
G
V
A
A
G
M
A
G
L
L
P
A
E
G
-----------------
Q
T
P
D
S
K
T
---
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
F
R
GFL------
A
I
I
---
P
---------
I
L
I
G
V
L
V
G
Y
A
L
S
F
A
M
G
I
V
--
D
T
T
P
----------
I
I
N
A
H
W
F
A
L
P
T
L
Y
T
P
--
R
------
F
--
E
W
----
F
A
I
L
T
I
L
-
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
---
K
KDLL
R
D
P
G
L
H
R
S
------------
M
F
A
N
G
L
S
T
V
I
S
G
F
F
G
S
T
P
N
T
T
Y
G
E
N
I
G
V
M
A
I
T
----
R
V
-----
Y
S
T
W
V
I
G
G
A
A
--------------
I
F
A
I
L
L
-----
S
C
V
G
K
L
A
A
A
I
Q
M
I
P
L
P
V
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
G
I
R
V
L
I
E
S
K
V
D
----------------------
Y
-
N
--
K
A
Q
N
L
I
L
T
-
S
V
I
L
I
-
I
G
V
S
GAKVNIGAAEL
K
G
-
M
A
L
A
T
I
V
G
I
G
L
S
L
I
F
K
L
I
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
55.15
21%
-95
- C2 -
4DGH
8
?
A:
[15-124]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
P
R
-
E
L
A
V
Y
A
L
E
G
P
F
F
F
A
A
A
E
T
F
E
R
V
M
G
S
I
Q
------
E
T
P
Q
I
L
I
L
R
L
K
W
V
P
F
M
-
D
I
T
G
I
Q
T
L
E
E
-
M
I
Q
S
F
H
K
R
G
I
K
V
L
I
S
G
A
N
S
R
V
S
Q
K
L
V
K
A
G
I
V
K
-
L
----
V
G
E
Q
N
-
V
Y
P
V
F
E
-------------------
G
A
L
S
A
A
L
T
-------
27
HHSearch
53.28
19%
-64
- C2 -
1H4X
1
SP2AA_LYSSH
A:
[8-112]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
-
E
T
V
V
I
R
L
F
G
E
L
D
H
H
A
V
E
Q
I
R
A
K
I
S
T
A
I
-
F
Q
---
G
A
V
T
T
I
I
W
N
F
E
R
L
S
F
M
-
D
S
S
G
V
G
L
V
L
G
-
R
M
R
E
L
E
A
V
A
G
R
T
I
L
L
N
P
S
P
T
M
R
K
V
F
Q
F
S
G
L
G
P
-
W
-------
M
--
M
D
A
T
E
E
-------------------
E
A
I
D
R
V
R
--------
12
PsiBlast_PDB
53.05
23%
-94
- C2 -
3MGL
4
?
A:
[21-121]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
V
Y
A
L
E
G
P
F
F
F
A
A
A
E
T
F
E
R
V
M
G
S
I
---
Q
E
-
T
P
Q
I
--
L
I
L
R
L
K
W
V
P
F
M
-
D
I
T
G
I
Q
T
L
E
E
-
M
I
Q
S
F
H
K
R
G
I
K
V
L
I
S
G
A
N
S
R
V
S
Q
K
L
V
K
A
G
I
V
K
-
L
----
V
G
E
Q
N
-
V
Y
P
V
F
E
-------------------
G
A
L
S
A
----------
30
HHSearch
52.74
16%
-72
- C2 -
4QTP
5
?
A:
[33-139]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
D
-
G
V
S
V
V
S
V
S
G
E
I
D
M
V
T
A
P
A
L
E
Q
A
I
G
A
V
V
-
A
----
D
S
P
P
A
L
V
I
D
L
S
A
V
E
F
L
-
G
S
V
G
L
K
I
L
A
A
-
T
Y
E
K
L
G
K
E
T
-
G
F
G
V
V
A
R
G
P
A
T
R
R
P
I
H
L
T
G
L
D
K
-
T
-------
F
P
-
L
Y
P
T
L
D
-------------------
D
A
L
T
A
V
R
D
-------
11
PsiBlast_PDB
52.74
25%
-73
- C2 -
4DGF
3
?
A:
[10-115]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
-
P
D
A
T
S
K
K
V
V
P
L
G
V
E
I
Y
E
I
N
G
P
F
F
F
G
V
A
-
D
R
L
K
G
V
L
D
V
I
-
E
E
T
-
P
---
K
V
F
I
L
R
M
R
R
V
P
V
I
-
D
A
T
G
M
H
A
L
W
E
-
F
Q
E
S
C
E
K
R
G
T
I
L
L
L
S
G
V
S
D
R
L
Y
G
A
L
N
R
F
G
F
I
E
-
A
----
L
G
E
E
R
-
V
F
--------------------------------------
10
PsiBlast_PDB
52.45
25%
-73
- C2 -
3OIR
5
?
A:
[10-115]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
-
P
D
A
T
S
K
K
V
V
P
L
G
V
E
I
Y
E
I
N
G
P
F
F
F
G
V
A
-
D
R
L
K
G
V
L
D
V
I
-
E
E
T
-
P
---
K
V
F
I
L
R
M
R
R
V
P
V
I
-
D
A
T
G
M
H
A
L
W
E
-
F
Q
E
S
C
E
K
R
G
T
I
L
L
L
S
G
V
S
D
R
L
Y
G
A
L
N
R
F
G
F
I
E
-
A
----
L
G
E
E
R
-
V
F
--------------------------------------