@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2014: (2016-05-06 )
MLHDRLTGAPRGATGDEGAANAHITRAMVAALTSVATQIKTLDAQIAEQLSLHADAHIFTSLPRSGTVRAARLLAEIGDCRARFPTPESLACLAGVAPSTRQSGKVKHVGFRWAADKQLRDAVCDFAGDSRRANLWAADRYNRAIARGHDHPHAVRILARAWLYAIWHCWQDGAAYHPANHRALQALLNQDQDRAA
Atome Classification :
(20 SA)
----------------------------------------------.-........10........20.--....-----------...30........---40........50.----------.--------......60.-----....------------------------...70........---80...-.--.--...90....-.-..-.100....--...110.---------------------...-...120....-...130.......140-----------.......150-..----.....----160....----...--170--.......180..-----.....-190..-..-----------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------M-LHDRLTGAPRGATGDEGAA
N
A
--
H
I
T
R
-----------
A
M
V
A
A
L
T
S
V
A
T
Q
I
---
K
T
L
D
A
Q
I
A
E
Q
L
S
L----------H--------AD
A
H
I
F
TSL-----PRSG------------------------
T
V
R
A
A
R
L
L
A
E
I
G
D
---
C
RARF-P--T--
P
E
S
L
A
C
L
AG-V-AP-STRQSGKV--
K
H
V
G
F
R
W---------------------AA
D
-
K
Q
L
R
D
A
V
C
DF-AGDSRRANLW
A
A
DRY
N
-----------
R
A
I
ARGHDH
P
-
H
A
----
V
R
I
L
A
----
R
A
W
L
Y
A
I
----
W
H
C
--WQD--GAAYHPA
N
H
R
A
L
-----
Q
A
L
L
N-QDQDR-AA-----------------------------------------------------------------------------------------------------------------------------------
33
Fugue
81.90
20%
-60
- C1 -
4XGC
1
ORC2_DROME
B:
[62-352]
E
G
S
I
N
A
I
M
E
E
Y
R
S
Y
F
P
K
W
M
C
I
L
N
E
G
F
N
I
L
L
YGLGSK
H
Q
L
L
Q
S
F
H
R
E
V
-
L
H
K
Q
T
V
L
V
V
N
G
F
F
P
S
L
T
I
K
D
M
L
D
S
I
T
S
-----------
D
I
L
D
A
G
I
S
P
A
N
P
H
---
E
A
V
D
-
M
I
E
E
E
F
A
L
----------
I
--------
P
E
T
H
L
F
L
I
V
HNLDG
A
M
L
R
------------------------
N
V
K
A
Q
A
I
L
S
R
L
A
-------
R
I
-
P
--
N
--
I
H
L
L
A
S
I
D
H
-
I
N
T
P
-
L
L
W
D
Q
G
K
L
--
C
S
F
N
F
S
W
W
DCTTMLPYTNETAFENSLLV
L
A
L
-
S
S
M
R
S
V
F
S
S
L
-
T
T
N
S
R
G
I
Y
M
L
I
V
K
Y
Q
L
K
N
KGNATGMP
F
R
D
L
Y
S
S
C
R
E
A
-
F
L
----
V
S
-
S
D
----
L
A
L
R
A
Q
L
----
T
E
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--
L
D
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--
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L
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E
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I
PID
G
A
L
L
Q
-
Q
F
L
E
E
-
Q
E
-----------------------------------------------------------------------------------------------------------------------------------
31
Fugue
68.36
14%
-39
- C4 -
1BJ5
3
?
?:
[198-389]
----------------------------------------------------
L
K
C
A
S
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Q
K
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E
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A
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--
A
V
A
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-----------
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F
A
E
V
---
S
K
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T
E
----------
C
C
H
GD
L
L
E
C
A
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D
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A
D
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A
K
-----
Y
I
C
E
------------------------
N
Q
D
S
--
I
S
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L
K
E
---
C
C
E
K
--
P
--
L
--
L
E
K
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H
C
I
A
E
-
V
-
E
N
-
D
E
M
P
A
D
L
P
--
S
L
--------------------------
A
A
D
-
F
V
E
S
K
D
V
C
K
N
-
Y
A
E
A
-
K
D
V
F
L
G
M
F
L
Y
E
-----------
Y
A
R
R
H
P
D
Y
S
V
-
V
L
----
L
L
R
L
A
----
K
T
Y
E
T
T
L
----
E
K
C
CA
A
A
D
--
P
H
E
C
Y
A
K
V
F
D
E
F
-----
K
P
L
V
E
-
E
P
Q
N
L
-
I
K
-----------------------------------------------------------------------------------------------------------------------------------
30
Fugue
64.35
15%
-63
- C2 -
2VDW
-
MCES_VACCW
B:
[1-287]
--------------M
D
E
I
V
K
N
I
R
E
G
T
H
V
L
L
P
F
Y
ETL
P
E
L
N
L
S
L
G
K
S
P
-
L
P
S
L
E
Y
G
A
N
Y
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D
L
N
--
R
M
P
T
-----------
D
M
L
K
L
F
T
H
D
I
M
L
P
---
E
S
D
L
D
K
V
Y
E
I
L
K
I
NSVKYYGRST
K
--------
A
D
A
V
V
A
D
L
S
-----
A
R
N
K
LFKRE
R
D
A
I
KSTENNLYISDYKML
T
F
D
V
F
R
P
L
F
D
F
V
N
EK
Y
C
I
I
K
L
-
P
--
T
--
L
F
G
R
G
V
I
D
T
-
M
-
R
I
-
Y
C
S
L
F
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N
V
--
R
L
--
L
K
C
---------------------
V
S
D
-
S
W
L
K
D
S
A
I
M
V
-
A
S
D
V
C
K
K
N
L
D
L
F
M
S
H
V
-----------
K
S
V
T
K
S
S
S
W
K
-
D
V
NS
V
Q
F
S
I
L
N
NPVD
T
E
F
I
N
K
F
----
L
E
F
--
S
N
R
--
V
Y
E
A
L
Y
Y
V
H
S
L
L
-----
Y
S
S
M
T
-
S
D
S
K
S
-
I
E
N
K
H
Q
R
R
L
V
K
L
LL-----------------------------------------------------------------------------------------------------------------------
28
Fugue
62.84
15%
-52
* C5 *
1WPI
-
FMP46_YEAST
A:
[1-133]
----------------------------------------------
M
S
F
W
K
T
L
Q
R
Q
P
R
T
I
S
L
F
T
N
D
I
A
S
--
N
I
K
S
-----------
Q
K
C
L
Q
L
L
K
G
D
V
S
----
H
R
F
D
V
E
I
A
N
R
F
P
T
----------
W
--------
D
Q
L
Q
Y
M
R
T
S
-----
C
P
Q
G
------------------------
P
V
S
L
Q
R
Q
I
P
K
L
D
S
---
V
L
K
Y
K
-
H
--
T
--
D
P
T
F
G
---------------------------------------------------------------------------
M
D
L
Q
-----------
K
C
V
Q
R
G
L
W
N
P
-
K
E
------------------
A
L
----
W
V
D
--
W
E
N
--
K
L
V
G
N
--
E
P
A
D
I
-----
D
K
Y
I
I
-
Q
R
K
----------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
62.61
15%
-70
* C4 *
3FES
2
?
A:
[4-143]
------------------------------------------------------------------
N
F
N
--
R
F
T
Q
-----------
R
A
K
K
A
I
D
L
A
F
E
S
A
---
K
S
L
G
H
N
I
V
------------------------
G
S
E
H
I
L
L
G
L
-----
L
R
E
E
------------------------
E
G
I
A
A
K
V
L
S
K
V
G
----------------
F
T
E
A
Y
L
E
G
K
-
I
-
V
D
M
E
G
K
G
E
E
I
S
--
E
D
I
V
L
S
P
---------------------
R
S
K
-
Q
I
L
E
L
S
---
G
M
F
A
N
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L
K
T
N
Y
I
G
T
E
H
I
L
-----------
L
A
I
I
Q
E
G
E
G
--
I
A
----
N
K
I
L
N
----
Y
A
-----------------------
G
V
N
D
R
T
L
A
-----
Q
L
T
I
D
M
G
------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
54.84
11%
-20
- C4 -
4OMV
-
?
A:
[0-202]
--------------------------------------------------------
A
M
L
L
Y
T
K
K
D
D
I
Y
S
--
D
I
V
R
-----------
M
I
L
L
I
K
G
A
N
A
K
I
V
DVS
K
E
E
N
S
K
H
L
E
E
L
N
I
----------
I
--------
T
P
N
G
N
I
P
T
L
-----
S
T
D
D
------------------------
F
A
V
Y
-
R
L
S
V
I
I
E
A
---
I
E
D
L
Y
-
P
--
F
--
P
P
----
M
F
P
-
V
-
F
P
-
K
Q
R
A
N
A
R
I
L
L
E
Y
V
N
K
T
F
---------------------
L
Q
N
I
I
K
L
Q
S
P
D
L
D
E
-
K
Q
A
N
E
I
K
M
L
M
Q
R
D
I
I
S
-----------
T
Y
K
K
I
V
S
E
R
A
-
Q
N
----
I
N
V
L
T
----
L
I
I
T
F
V
F
----
Y
Y
F
--
I
K
L
--
K
I
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I
P
T
K
D
K
N
I
I
-----
K
E
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K
E
-
L
L
S
E
P
-
N
F
I
K
T
I
K
A-----------------------------------------------------------------------------------------------------------------------------
35
Fugue
53.96
11%
-29
- C5 -
4AXV
2
?
A:
[1-241]
-----------------------------------VLFQGPAMSLI
P
-
R
T
E
R
A
A
F
L
I
T
P
T
S
Y
G
K
S
V
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G
A
--
P
L
L
Y
F
P
AQVESNS
R
G
L
I
L
A
G
T
H
G
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E
T
A
S
---
I
A
G
L
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C
A
L
R
S
L
P
A
----------
E
--------
C
L
K
H
D
V
I
L
S
M----
N
P
D
A
------------------------
N
Q
L
G
T
R
A
N
A
N
Q
V
D
---
L
N
R
A
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Q
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W
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E
H
G
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-
Y
-
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W
-
S
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--
V
K
V
K
T
G
D
---------------------
K
E
Q
-
L
E
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E
V
D
A
L
I
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-
L
I
E
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R
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P
K
F
V
V
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F
H
E
P
-----------
L
A
F
V
D
D
P
A
H
S
-
D
L
----
A
K
W
L
G
----
K
Q
F
N
L
P
I
V
D
DV
D
Y
E
--
T
P
G
S
F
G
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W
C
N
E
R
Q
L
P
C
I
-----
T
V
E
L
P
-
P
I
S
A
D
-
L
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H
L
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A
F
I
A
L
L
Q
HDP-------------------------------------------------------------------------------------------------------------------
17
HHSearch
53.76
27%
-58
- C6 -
2BGW
2
?
A:
[161-203]
----------------------------------------------------------------------------------------------------------------------------------------
L
Y
I
L
Q
S
F
-----
P
G
I
G
------------------------
R
R
T
A
E
R
I
L
E
R
F
G
S
----
L
E
R
F
-
F
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A
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--
K
A
E
I
S
K
V
E
G
-
I
-
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
50.77
18%
-9
- C4 -
4KT3
-
?
A:
[29-177]
--------------------------------------------------------------
A
R
L
C
N
N
I
--
S
A
V
T
-----------
F
V
S
K
Y
K
A
V
C
Q
P
I
A
---
D
Q
L
D
L
P
V
E
N
L
L
G
L
----------
A
--------
A
Q
E
S
Q
Y
G
T
--------------------------------------
G
R
I
A
R
E
L
N
N
---------------------
Y
F
S
M
H
-
A
P
-
A
P
L
Q
I
G
A
E
--
A
P
---------------------------------
S
I
K
V
A
K
F
-
D
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F
Q
K
S
A
Q
S
F
A
S
S
F
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T
-----------
A
V
--
R
G
Q
R
D
P
M
A
F
----
A
Q
A
L
V
----
R
S
G
-------------
Y
N
T
--
G
N
G
-
R
D
G
F
A
R
Y
L
-----
A
D
I
I
I
-
A
V
R
G
R
M
A
C
-----------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
49.58
26%
-31
- C6 -
2DUY
1
?
A:
[25-66]
---------------------------------------------------------------------------------------------------------------------------------------
S
L
E
E
L
M
A
L
-----
P
G
I
G
------------------------
P
V
L
A
R
R
I
V
E
G
R
--------
P
Y
-
A
--
R
--
V
E
D
L
L
K
V
K
G
-
I
-
G
P
-
A
T
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
48.68
17%
-76
* C6 *
3PLA
1
?
A:
[226-289]
----------------------------------------------------------------
S
E
D
D
L
--
S
A
M
R
-----------
M
I
A
N
T
I
L
D
L
Y
N
I
R
---
R
N
L
N
N
Y
L
E
G
V
M
K
E
----------
V
----------
A
P
N
V
T
A
L
-------
V
G
------------------------
P
A
L
G
A
R
L
L
S
I
A
G
S
----
L
D
E
L
-
A
--
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
48.48
14%
-31
- C3 -
4WID
1
?
A:
[10-362]
---------------------KDMAL
Q
H
A
V
D
L
L
E
K
M
L
A
D
E
E
KLTEF
N
-
L
G
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A
N
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--
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-----------
D
V
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A
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---
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-
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R
N
R
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A
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----------
E
--------
I
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E
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L
T
D
I
-----
R
K
V
F
------------------------
S
D
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E
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L
E
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G
I
Q
N
---
S
Y
L
L
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D
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--
L
--
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M
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C
-
L
-
F
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P
V
P
P
Q
Y
---------------------
K
E
F
-
M
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I
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Q
Y
-
A
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N
S
S
S
L
E
K
F
V
M
L
----------------
I
T
K
K
D
D
I
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-
D
R
----
V
T
Y
T
C
----
M
K
Y
L
L
M
A
----
M
Q
G
--
T
G
G
--
P
K
A
I
N
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E
E
H
A
K
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-----
F
F
Q
L
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-
N
Y
D
D
L
-
T
D
A
N
H
D
G
L
E
L
I
K
K
L
D
KEQ
K
E
V
A
F
H
V
N
N
F
T
H
L
V
T
T
L
G
M
A
L
Y
K
E
G
H
Q
K
N
D
E
A
M
L
G
M
H
T
P
I
T
M
L
S
D
Q
V
R
V
L
I
L
Y
L
I
D
E
I
V
H
A
I
H
T
NSNQS
N
D
E
L
I
D
G
L
K
P
K
V
R
I
V
I
N
E
F
H
A
T
L
M
M
GIDK
M
K
F
Y
S
L
N
E
L
R
E
I
V
N
D
K
I
14
HHSearch
48.14
23%
-57
- C6 -
2EDU
-
A:
[39-81]
----------------------------------------------------------------------------------------------------------------------------------------
A
R
D
L
R
S
L
-----
Q
R
I
G
------------------------
P
K
K
A
Q
L
I
V
G
W
R
E
L
----
H
G
P
F
-
S
--
Q
--
V
E
D
L
E
R
V
E
G
-
I
-
T
G
-
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
46.09
21%
-59
- C6 -
2NRT
1
A:
[167-207]
----------------------------------------------------------------------------------------------------------------------------------------
R
S
V
L
D
N
V
-----
P
G
I
G
------------------------
P
I
R
K
K
K
L
I
E
H
F
G
S
----
L
E
N
I
-
R
--
S
AS
L
E
E
I
A
R
V
I
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
40.73
14%
-46
- C6 -
4BXO
-
A:
[179-207]
----------------------------------------------------------------------------------------------------------------------------------------
L
Q
F
Y
L
S
I
-----
P
N
I
S
------------------------
Y
I
T
A
L
N
M
C
H
Q
F
S
S
----
V
K
R
M
-
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
40.62
36%
-26
- C6 -
3U1T
2
?
A:
[157-201]
----------------------------------------------------------------------------------------------------------
A
D
V
G
E
K
M
V
L
----------
D
--------
G
N
F
F
V
E
T
I
L
-----
P
E
M
G
------------------------
V
V
R
S
L
S
-
E
A
E
M
A
A
---
Y
R
A
P
F
-
P
--
T
--
R
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
39.92
9%
-65
- C6 -
2OZB
-
PRP31_HUMAN
B:
[107-180]
----------------------------------------------------------------
S
E
E
E
L
--
E
R
L
E
-----------
E
A
C
D
M
A
L
E
L
N
A
S
K
---
H
R
I
Y
E
Y
V
E
S
R
M
S
F
----------
I
----------
A
P
N
L
S
I
I
-------
I
G
------------------------
A
S
T
A
A
K
I
M
G
V
A
G
G
----
L
T
N
L
-
S
--
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
34.57
11%
-32
- C6 -
1Z00
-
XPF_HUMAN
B:
[838-865]
----------------------------------------------------------------------------------------------------------------------------------------
Q
D
F
L
L
K
M
-----
P
G
V
N
------------------------
A
K
N
C
R
S
L
M
H
H
V
K
N
----
I
A
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
32.19
31%
6
- C6 -
4ITQ
1
?
A:
[56-81]
--------------------------------------------------------------------------------------------------------------------------------------
K
V
S
A
L
L
E
S
L
-----
P
G
V
G
------------------------
K
V
R
A
K
Q
I
M
E
R
L
G
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
31.39
11%
-24
- C6 -
2A1J
-
A:
[4-30]
-----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
L
K
M
-----
P
G
V
N
------------------------
A
K
N
C
R
S
L
M
H
H
V
K
N
----
I
A
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------