@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2374c: (2016-05-10 )
MGSADERRFEVLRAIVADFVATQEPIGSKSLVERHNLGVSSATVRNDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRLEDVKPLSSAERRAIQSFLESGVDLDDVLRRAVRLLAQLTRQVAVVQYPTLSTSTVRHLEVIALTPARLLMVVITDSGRVDQRIVELGDVIDDHQLAQLREILGQALEGKKLSAASVAVADLASQLGGAGGLGDAVGRAATVLLESLVEHTEERLLLGGTANLTRNAADFGGSLRSILEALEEQVVVLRLLAAQQEAGKVTVRIGHETASEQMVGTSMVSTAYGTAHTVYGGMGVVGPTRMDYPGTIASVAAVALYIGDVLGAR
Atome Classification :
(20 SA)
----.........10........20----.-...-....30-........40........50........60.-----.......70........80..-------......90........-100.-.......110.......120.......130.......140.......150....-----...160........170------........180--..-......190.....-..200.......210..-.....220.......230.......240.......250.....--...260.......270.......280.......290.......300.......310.......320.......330.......340.-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MG
S
A
D
E
R
R
F
E
V
L
R
A
I
V
A
D
F
V
A----T-QEP-IG
S
K
S
L
-
V
E
R
HNLGVSSATVRN
D
M
A
V
L
EAE
G
Y
I
TQPHT-----SSGRVP
T
E
K
G
Y
R
E
F
V
D
R
L
EDV-------KP
L
S
S
A
E
R
R
A
I
Q
S
F
L
E
-S-GV-
D
L
D
D
V
L
R
R
A
V
R
L
L
A
Q
L
T
R
Q
V
A
V
V
QYPTLSTS
T
V
R
H
L
E
V
I
A
LTPA
R
L
L
M
V
V
ITDS-----GR
V
D
-
Q
R
I
V
E
L
G
DVI
D
-------
D
H
Q
L
A
Q
L
R
E
I
---
L
G
-
Q
A
LEGKKL
S
A
A
S
V
A
-
V
A
D
L
A
S
QLGGAGG
L
G
D
A
-
V
G
R
A
A
T
V
L
L
E
S
L
V
E
H
T
E
E
R
L
L
LGGTANLTR
N
A
A
DF
G
-
G
S
L
R
S
I
--
L
E
A
L
E
E
Q
V
V
V
L
R
L
L
A
AQQEA
G
K
V
T
V
R
IGHETA
S
E
Q
M
V
G
T
S
M
V
S
TAYGT
A
H
T
VYGGMGVVGPTRMDYP
G
T
I
A
S
V
A
A
V
A
L
Y
I
G
D
V
LGAR-
43
Fugue
90.78
25%
-97
- C5 -
1STZ
-
HRCA_THEMA
A:
[14-336]
------
K
L
N
D
R
Q
R
K
V
L
Y
C
I
V
R
E
Y
I
E
----
N
-
K
K
P
-
V
S
S
Q
R
V
-
L
E
V
S
N
I
E
F
S
S
A
T
I
R
N
D
M
K
K
L
E
Y
L
G
Y
I
Y
Q
P
H
T
-----
S
A
G
R
I
P
T
D
K
G
L
R
F
Y
Y
E
E
M
L
K
I
-------
S
K
E
T
S
E
A
D
L
A
V
E
T
F
K
S
M
P
-
L
A
-
D
P
E
K
V
L
F
L
A
G
N
L
L
A
R
L
T
E
G
Y
V
L
I
E
R
P
N
T
R
D
L
K
I
L
R
V
M
L
I
P
V
S
E
D
Y
L
I
F
S
I
L
T
E
F
-----
G
V
S
K
-
V
T
P
I
K
T
Q
E
----------
R
L
N
W
E
E
I
E
R
Q
---
L
N
-
F
L
L
R
G
R
T
V
G
E
V
L
M
-------------
G
K
I
E
S
L
-
K
G
S
G
F
L
R
L
I
E
S
L
I
G
E
T
V
E
R
Y
L
D
A
G
L
E
N
L
L
K
D
E
T
L
T
L
-
E
D
I
R
N
L
--
L
E
E
V
K
D
Q
K
F
L
E
S
L
V
G
-----
E
G
I
T
V
R
I
G
R
E
I
G
R
K
K
L
E
K
F
A
V
F
S
G
K
Y
F
K
G
E
S
P
I
G
S
V
Y
L
F
T
S
K
V
T
K
Y
D
R
N
H
R
V
F
E
Y
I
L
N
R
L
S
E
Y
F
T
S
T
S
21
HHSearch
88.84
24%
-102
- C5 -
1STZ
-
HRCA_THEMA
A:
[14-334]
------
K
L
N
D
R
Q
R
K
V
L
Y
C
I
V
R
E
Y
I
E
----
N
-
K
K
P
-
V
S
S
Q
R
V
-
L
E
V
S
N
I
E
F
S
S
A
T
I
R
N
D
M
K
K
L
E
Y
L
G
Y
I
Y
Q
P
H
T
-----
S
A
G
R
I
P
T
D
K
G
L
R
F
Y
Y
E
E
M
L
K
I
-------
S
K
E
T
S
E
A
-
D
L
A
V
E
T
F
K
S
M
P
L
A
-
D
P
E
K
V
L
F
L
A
G
N
L
L
A
R
L
T
E
G
Y
V
L
I
E
R
P
N
T
R
D
L
K
I
L
R
V
M
L
I
P
V
S
E
D
Y
L
I
F
S
I
L
T
E
F
-----
G
V
S
K
-
V
T
P
I
K
T
Q
E
R
L
----------
N
W
E
E
I
E
R
Q
---
L
N
-
F
L
L
R
G
R
T
V
G
E
V
L
M
G
-
K
I
E
S
L
K
---------
G
---
S
G
F
L
R
L
I
-
E
S
L
I
G
E
T
V
E
R
Y
L
D
A
G
L
E
N
L
L
K
-
D
E
T
L
T
L
E
D
I
R
N
L
--
L
E
E
V
K
D
Q
K
F
L
E
S
L
V
-----
G
E
G
I
T
V
R
I
G
R
E
I
G
R
K
K
L
E
K
F
A
V
F
S
G
K
Y
F
K
G
E
S
P
I
G
S
V
Y
L
F
T
S
K
V
T
K
Y
D
R
N
H
R
V
F
E
Y
I
L
N
R
L
S
E
Y
F
T
S
--
1
PsiBlast_PDB
80.52
28%
-94
- C5 -
1STZ
-
HRCA_THEMA
A:
[14-304]
------
K
L
N
D
R
Q
R
K
V
L
Y
C
I
V
R
E
Y
I
E
----
N
-
K
K
P
-
V
S
S
Q
R
V
-
L
E
V
S
N
I
E
F
S
S
A
T
I
R
N
D
M
K
K
L
E
Y
L
G
Y
I
Y
Q
P
H
T
-----
S
A
G
R
I
P
T
D
K
G
L
R
F
Y
Y
E
E
M
L
K
I
-------
S
K
E
T
S
E
A
D
L
A
V
E
T
F
K
S
-
M
-
P
L
A
D
P
E
K
V
L
F
L
A
G
N
L
L
A
R
L
T
E
G
Y
V
L
I
E
R
P
N
T
R
D
L
K
I
L
R
V
M
L
I
P
V
S
E
D
Y
L
I
F
S
I
L
T
E
F
-----
G
-------
V
S
K
V
T
P
I
K
-------
T
Q
E
R
L
N
W
E
E
I
E
R
Q
L
N
-
F
L
L
R
G
R
--
T
V
G
E
V
L
-
M
G
K
I
E
S
-
L
K
G
S
G
F
L
R
----------
L
I
E
S
L
I
G
E
T
V
E
R
Y
L
D
A
G
L
E
N
L
L
K
D
E
T
L
T
L
-
E
D
I
R
N
L
--
L
E
E
V
K
D
Q
K
F
L
E
S
L
V
G
E
G
-----
I
T
V
R
I
G
R
E
I
G
R
K
K
L
E
K
F
A
V
F
S
G
K
Y
F
K
G
E
S
P
I
G
S
V
--------------------------------
46
Fugue
53.53
14%
-75
- C4 -
1MKM
2
?
A:
[4-249]
---------
M
N
T
L
K
K
A
F
E
I
L
D
F
I
V
K
----
N
-
P
G
D
-
V
S
V
S
E
I
-
A
E
K
--
F
N
M
S
V
S
N
A
Y
K
Y
M
V
V
L
E
E
K
G
F
V
L
R
K
K
D
-----
K
R
Y
V
P
---------------------------
G
Y
K
L
I
E
Y
G
S
F
V
L
-
R
-
R
F
-
N
I
R
D
I
A
H
D
H
L
V
D
I
M
K
R
T
G
E
T
---------------
V
H
L
I
L
K
D
G
F
E
G
V
Y
I
D
K
V
E
G
-----
E
Q
S
I
-
P
M
V
S
R
L
G
M
K
V
D
-------
L
Y
-------------------------------------------
S
T
A
-
S
G
K
S
I
L
A
F
V
P
--
E
K
E
L
K
E
Y
L
K
I
V
E
L
K
P
K
T
P
N
T
I
T
N
P
-
R
V
L
K
R
E
--
L
E
K
I
R
K
R
G
Y
A
V
D
N
--
E
E
N
E
I
G
I
M
C
V
G
V
P
I
F
D
H
N
G
Y
P
V
A
G
V
S
I
S
G
V
A
R
K
F
------------
T
E
E
K
I
E
E
Y
S
D
V
L
K
E
K
A
E
E
I
S
R
K
L
G
Y
--
47
Fugue
48.41
20%
-49
- C4 -
4WD8
4
?
A:
[25-292]
----
S
K
I
I
F
R
L
L
L
N
V
L
M
S
I
I
A
I
I
S
Y
----
Q
-
W
Y
E
------------
Q
L
G
I
H
L
T
V
A
P
F
S
L
L
G
I
A
I
A
I
F
L
G
F
R
N
S
-----
A
S
--------
Y
S
R
F
V
E
A
R
N
L
W
-------
G
T
V
L
I
A
E
R
T
L
V
R
Q
L
R
N
-
I
-
L
P
-
A
E
H
D
A
H
R
R
I
V
S
Y
L
V
A
F
S
W
S
L
K
H
Q
L
R
K
T
D
P
T
A
D
L
R
R
L
------
L
P
E
E
R
V
T
E
I
L
A
S
-----
S
M
P
T
-
N
R
I
L
L
L
A
G
-----------
N
E
I
G
Q
L
R
E
-----
A
-
G
K
L
S
D
I
T
Y
G
L
M
D
N
K
-
L
D
E
L
A
H
V
L
G
G
C
E
R
L
A
T
T
P
V
P
F
A
Y
T
L
I
L
Q
R
T
V
Y
L
F
C
T
L
L
P
F
A
L
V
G
D
L
----------------------------
H
Y
M
T
P
F
V
S
V
F
I
S
Y
T
F
L
S
W
D
S
L
A
E
E
L
------
E
D
P
F
G
T
A
A
N
-------------
D
L
P
-
L
N
A
M
C
N
T
I
E
R
N
L
L
D
M
T
G
Q
--
29
HHSearch
48.20
18%
-51
- C5 -
1ON2
1
MNTR_BACSU
A:
[2-69]
-------
T
T
P
S
M
E
M
Y
I
E
Q
I
Y
M
-
L
I
E
----
E
-
K
G
Y
-
A
R
V
S
D
I
-
A
E
A
--
L
A
V
H
P
S
S
V
T
K
M
V
Q
K
L
D
K
D
E
Y
L
I
Y
E
K
------
Y
R
G
L
V
L
T
S
K
G
K
K
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
44.88
22%
-27
- C5 -
1FX7
3
IDER_MYCTU
A:
[1-74]
----
M
N
E
L
V
D
T
T
E
M
Y
L
R
T
I
Y
D
L
E
E
E
------
G
V
T
-
P
L
R
A
R
I
-
A
E
R
--
L
D
Q
S
G
P
T
V
S
Q
T
V
S
R
M
E
R
D
G
L
L
R
V
A
G
D
------
R
H
L
E
L
T
E
K
G
R
A
L
A
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
43.68
15%
-22
- C5 -
2CYY
3
REG6_PYRHO
A:
[3-68]
-----
V
P
L
D
E
I
D
K
K
I
I
K
I
L
Q
---------
N
-
D
G
K
-
A
P
L
R
E
I
-
S
K
I
--
T
G
L
A
E
S
T
I
H
E
R
I
R
K
L
R
E
S
G
V
I
K
K
F
T
A
-------
I
I
D
P
E
A
L
G
Y
S
M
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
42.90
20%
-22
- C5 -
2X4H
1
?
A:
[11-77]
-------
L
S
R
R
E
F
S
Y
L
L
T
I
K
R
Y
N
D
-----
S
-
G
E
G
-
A
K
I
N
R
I
-
A
K
D
--
L
K
I
A
P
S
S
V
F
E
E
V
S
H
L
E
E
K
G
L
V
K
K
K
E
-------
D
G
V
W
I
T
N
N
G
T
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
41.16
21%
-24
- C5 -
2CG4
1
ASNC_ECOLI
A:
[4-69]
-----
Y
L
I
D
N
L
D
R
G
I
L
E
A
L
M
---------
G
-
N
A
R
-
T
A
Y
A
E
L
-
A
K
Q
--
F
G
V
S
P
E
T
I
H
V
R
V
E
K
M
K
Q
A
G
I
I
T
G
A
R
I
-------
D
V
S
P
K
Q
L
G
Y
D
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
40.38
17%
-16
- C5 -
4OU0
-
RFA2_HUMAN
A:
[204-266]
------
G
L
T
V
A
Q
N
Q
V
L
N
L
I
K
A
-
P
------
R
-
P
E
G
-
L
N
F
Q
D
L
-
K
N
Q
L
K
-
H
M
S
V
S
S
I
K
Q
A
V
D
F
L
S
N
E
G
H
I
Y
S
T
V
D
-----
D
D
H
F
K
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
40.29
12%
-77
- C2 -
5CS0
-
ACAC_YEAST
A:
[797-1031]
-----------------------------------------------------------------------------------
K
P
A
Y
K
F
K
S
L
V
S
T
L
E
N
I
L
K
GYD
N
Q
V
I
M
N
A
S
L
Q
Q
L
I
E
V
L
R
N
-
P
-
K
L
-
P
Y
S
E
W
K
L
H
I
S
A
L
H
S
R
L
P
A
K
L
D
E
Q
M
E
E
L
V
A
R
S
L
R
R
G
A
V
F
P
A
R
Q
L
S
K
L
I
D
M
A
V
K
N
P
EYNPD
K
L
L
G
-
A
V
V
E
P
L
A
D
I
A
H
K
Y
S
NG
L
E
A
H
E
H
S
I
F
V
H
F
---
L
E
-
E
Y
Y
E
V
E
K
L
F
D
L
D
K
V
-
A
L
T
V
L
S
H
---------
S
-
K
V
S
A
K
N
N
L
I
L
A
I
L
K
H
Y
Q
P
L
C
K
L
---------
S
S
K
V
S
-
A
I
F
S
T
P
--
L
Q
H
I
V
E
-
L
E
S
K
A
T
A
K
V
A
L
Q
A
R
E
I
L
I
Q
--------------------------------------------------------------
38
HHSearch
39.43
19%
-40
- C5 -
2P5V
-
?
A:
[6-59]
-----
L
T
L
D
K
T
D
I
K
I
L
Q
V
-----
L
Q
----
E
-
N
G
R
-
L
T
N
V
E
L
-
S
E
R
--
V
A
L
S
P
S
P
C
L
R
R
L
K
Q
L
E
D
A
G
I
V
R
Q
Y
A
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
38.94
10%
-48
- C1 -
1K1Q
-
DPO4_SULSF
A:
[1-344]
M
I
V
I
F
V
D
F
D
Y
F
F
A
Q
V
E
E
V
L
N
P
Q
Y
K
G
----
K
-
P
L
V
-
V
S
V
Y
S
A
N
Y
E
A
R
K
L
G
V
K
A
G
M
P
I
I
K
A
M
Q
I
A
P
S
A
I
Y
V
P
M
R
K
-----
P
I
Y
E
A
F
S
N
R
I
M
N
L
L
N
K
H
A
D
K
I
-------
E
V
A
S
I
D
-----
E
A
Y
L
D
-
V
-
T
N
-
K
V
E
G
N
F
E
N
G
I
E
L
A
R
K
I
K
Q
E
I
L
E
K
E
K
I
T
V
T
---------
V
G
V
A
P
N
K
I
L
A
K
I
I
A
D
K
-----
S
K
P
N
G
L
G
V
I
R
P
T
E
V
Q
D
-------
F
L
N
E
L
D
I
D
E
I
---
P
G
I
G
S
V
L
A
R
R
L
N
E
L
G
I
Q
K
L
R
D
I
L
S
K
--
N
Y
N
E
L
E
K
I
-
T
G
K
A
K
A
L
Y
L
L
K
L
A
Q
N
K
Y
S
E
P
V
E
N
K
S
K
I
P
H
G
R
Y
L
T
L
P
-
Y
N
T
R
D
V
K
V
I
L
P
Y
L
K
K
A
I
N
E
A
Y
N
K
V
N
G
I
P
M
R
I
T
V
I
A
I
M
E
D
-
L
D
I
L
S
K
G
K
K
F
K
H
G
I
S
I
D
N
A
Y
K
V
A
E
D
L
L
R
E
L
L
V
R
D
K
R
R
--
N
V
R
R
I
G
V
K
L
D
N
I
I
I
N
--
31
HHSearch
38.86
13%
-11
* C5 *
4XRF
8
?
A:
[30-101]
------
G
L
T
P
P
Q
F
Y
I
L
K
I
L
-----
D
----
H
-
Y
G
A
-
S
R
A
T
T
L
-
A
K
K
--
M
Y
V
K
P
S
A
I
T
V
M
I
D
R
L
I
D
Q
E
L
V
E
R
Y
H
D
KDDRR
V
V
I
I
E
L
T
K
K
G
K
A
R
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
38.66
18%
-21
- C5 -
2OBP
1
?
A:
[13-70]
------
G
I
D
P
A
I
V
E
V
L
L
V
L
R
E
A
G
I
E
----
N
G
A
T
P
-
W
S
L
P
K
I
-
A
K
R
--
A
Q
L
P
M
S
V
L
R
R
V
L
T
Q
L
Q
A
A
G
L
A
D
V
S
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
38.39
24%
5
- C5 -
3S2W
2
?
A:
[47-119]
------
G
I
G
S
G
Q
F
P
F
L
M
R
L
-----
Y
----
R
-
E
D
G
-
I
N
Q
E
S
L
-
S
D
Y
--
L
K
I
D
K
G
T
T
A
R
A
I
Q
K
L
V
D
E
G
Y
V
F
R
Q
R
D
ER---
S
Y
R
V
F
L
T
E
K
G
K
K
L
E
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
38.15
25%
-29
- C5 -
1I1G
-
REG7_PYRFU
A:
[2-66]
-------
I
D
E
R
D
K
I
I
L
E
I
L
E
---------
K
-
D
A
R
-
T
P
F
T
E
I
-
A
K
K
--
L
G
I
S
E
T
A
V
R
K
R
V
K
A
L
E
E
K
G
I
I
E
G
Y
T
I
-------
K
I
N
P
K
K
L
G
Y
S
L
V
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
37.48
16%
-16
- C5 -
3I71
2
EUTK_ECOLI
A:
[4-52]
----------
S
A
D
E
L
L
A
L
L
T
----
S
----
V
-
R
Q
G
-
M
T
A
G
E
V
-
A
A
H
F
--
G
W
P
L
E
K
A
R
N
A
L
E
Q
L
F
S
A
G
T
L
R
K
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
37.42
18%
-19
- C5 -
4H0E
3
ARAR_BACSU
A:
[21-82]
-------
M
L
P
K
Y
A
Q
V
K
E
E
I
S
S
W
I
N
Q
GKIL
P
-
D
Q
K
I
P
T
E
N
E
L
-
M
Q
Q
F
--
G
V
S
R
H
T
I
R
K
A
I
G
D
L
V
S
Q
G
L
L
Y
S
V
Q
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------